It probably hasn't escaped your notice that today is Valentine's Day. Maybe it's a day you look forward to or a day you loathe in proportion to the amount of Valentine's you do or do not receive or your relationship status. But love, Real Love is so much bigger. It's just that a day like today can make many feel as though it's only romantic love that counts.
At the risk of sounding like a 'rom-com' cliché it's true that love is all around us in many forms and sometimes in the most unexpected of places, if only we choose to be aware.
For a slightly different take on Valentine's Day I wanted to share this 5 minute video with you where cardiothoracic surgeon Dr. Kathy Magliato explains how love affects us physically, how being a heart surgeon has impacted her own feelings about love and also why she believes the soul resides in the heart. This also ties in with the words of Dr. Mimi. Guarneri who is the author of my current Book of the Month, 'The Heart Speaks'.


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Program sections
2018 | THE AUDIENCE POLL
© Twój Vincent, Loving Vincent, dir. Dorota Kobiela, Hugh Welchman
LOVING VINCENT | Twój Vincent | dir. Dorota Kobiela, Hugh Welchman| PL, GB, US | 2017 | 94 min
prod|pro Hugh Welchman, Sean Bobbitt, Ivan Mactaggart scen|wr Dorota Kobiela, Hugh Welchman, Jacek Dehnel zdj|ph Tristan Oliver, Łukasz Żal muz|mus Clint Mansell mon|ed Justyna Wierszyńska, Dorota Kobiela ob|cast Douglas Booth, Eleanor Tomlinson, Jerome Flynn, Saoirse Ronan, Chris O'Dowd, John Sessions, Aidan Turner, Helen McCrory, Robert Gulaczyk dys|dis Next Film
"Loving Vincent" is unique because Vincent Van Gogh was exceptional. The film is an experimental animated biographical drama about the life of the painter Vincent van Gogh, especially about the circumstances of his death. The painter wrote in one of his last letters: "Only our images can speak for us". Van Gogh's art told his story. This is the first fully animated feature film to be made. The film, written and directed by Dorota Kobiela and Hugh Welchman, is a Polish production financed by the Polish Film Institute, and partly by the Kickstarter campaign. Each of the 65,000 frames of the film is an oil painting on canvas, using the same technique as Van Gogh, created by a team of 125 painters.
DOROTA KOBIELA (1978)
Polish filmmaker, screenwriter and producer. A graduate from the Academy of Fine Arts in Warsaw. Through friends Dorota discovered animation and film, and immediately threw herself into learning these new artistic disciplines, attending The Warsaw Film School, Direction Faculty. She has directed one live action short film and five animated shorts. For her sixth animated short "Loving Vincent" Dorota aimed to combine her passion for painting and film. "Loving Vincent" is her feature film debut.
HUGH WELCHMAN (1975)
He graduated with a degree from Oxford University in Politics, Philosophy and Economics. In 2002, Welchman founded the film company BreakThru Films. This led to him becoming the joint winner of the Academy Award for Best Animated Short Film in 2007 for the film "Peter and the Wolf" (2006) which he produced.
2018 FAF TWO RIVERSIDES Kazimierz Dolny, Janowiec – Audience Award
2018 Academy Awards Oscar – Best Animated Feature Film nomination
2018 Golden Globes – Best Motion Picture Animated nomination
2018 BAFTA Film Award – Best Animated Feature Film nomination
2018 David di Donatello Awards – Best European Film nomination
2017 Gdynia PFF Golden Lion for Best Film nomination
2017 Shanghai IFF – Golden Goblet for Best Animation Film
[youtube]1n1RFgapVq0[/youtube]
2020 | SHORT FILMS COMPETITION

redpajama_set_name: RedPajamaCommonCrawl


Between four and 26 weeks after giving birth, roughly one in four low-income women suffer from anemia; the proportion reaches nearly half, however, among those who were anemic during pregnancy and among black women. These findings, based on data for women enrolled in a federally sponsored nutrition program in 12 states,1 suggest a sharply higher prevalence of anemia among low-income women than has been found elsewhere among their better-off counterparts. They also indicate that although women's iron levels (which drop during pregnancy) typically recover 4-6 weeks after delivery, low-income women remain at risk of suffering from anemia for a substantially longer period. Consequently, standard screening protocols, based in part on the 4-6-week time frame, may be too limited to detect this condition in low-income women.
To determine the prevalence and predictors of postpartum anemia among low-income women, researchers gathered data on participants in the Special Supplemental Food Program for Women, Infants and Children (WIC) in 1996. The data, culled from a large-scale nutrition surveillance system, included nearly 60,000 women who entered WIC while they were pregnant, had a live birth and visited a WIC site once during the postpartum period. For this study, the researchers defined the postpartum period as 4-26 weeks after delivery, because maternal hemoglobin levels, which are reduced during pregnancy, should return to normal within this interval. Participants were predominantly non-Hispanic white (65%), unmarried (60%) and in their 20s (57%); the majority (64%) were high school graduates.
Twenty-seven percent of the women were anemic when they made their postpartum visit to WIC. At any given interval since delivery, the proportion who were anemic was at least 25%; it peaked at 29-33% among women visiting WIC 12-18 weeks after giving birth. The prevalence of postpartum anemia was highest among women who had been anemic during pregnancy (49%) and among black women (43% overall, including 48% of those who were 13-14 weeks postpartum). By comparison, 24% of women who had not suffered from prenatal anemia and 21% of white women had postpartum anemia.
In logistic regression analyses that controlled for the number of weeks since the birth and other factors that could contribute to the risk of anemia, prenatal anemia emerged as the strongest predictor of postpartum anemia: Women who had been anemic while pregnant had significantly elevated odds of postpartum anemia (odds ratio, 2.7). Compared with white women, blacks had more than twice the odds of postpartum anemia (2.3), and women belonging to other minority groups had about half again the odds (1.4-1.6).
A number of other variables had smaller but still significant associations with the risk of postpartum anemia. The odds grew with increasing prepregnancy body mass index and were significantly elevated for women aged 16-19, those who had had a multiple birth, women with no more than a high school education and those who were not married. Women who had been breastfeeding for more than three weeks had reduced odds of being anemic at their postpartum WIC visit (0.8 both for those who had been breastfeeding for 4-6 weeks and for those who had been doing so for longer).
1. Bodnar LM et al., High prevalence of postpartum anemia among low-income women in the United States, American Journal of Obstetrics and Gynecology, 2001, 185(2):438-443.


We carry a wide selection of quality engineered wood products for use in new home construction and home remodeling. In addition to our extensive line of in-stock engineered wood products, we also have the ability to special order many unique and "hard-to-find" items. Our knowledgeable engineered wood specialists can help you choose the right engineered wood product for your project and budget. If you can't find the engineered wood products you are looking for, or have questions on engineered wood, please contact us to inquire about your needs for your upcoming project.


TWO STYLISH TREATMENT ROOMS IN PREMIER LOCACTION.
Commencing business from the beginning of July, the clinic has four modern, clean rooms with two available to rent. The rooms can be rented for full days or half days for seven days a week with all expenses included.
Join our team and we will take care of the marketing, website and social media presence. The website and social media is frequently updated with articles and your profile will be included on the site to further drive your business. The clinic also has signage and main street frontage.
Due to the close proximity to GPs, specialists and both private and public hospitals, there is ample scope for referrals including within the practice itself.
The practice presently includes several Acupuncturists, Herbalists and a Naturopath, therefore we are looking for a variety of other professionals to complement our team, such as Massage therapists, Nutritionist and Myotherapist. We are open to other therapies and invite other health professionals or specialists to apply.
Each room will be fully furnished with desk and chairs, depending on the requirements of the practitioner. Pillows, throws and linen will also be provided by the clinic.
The rooms offer the use of an excellent reception and waiting area. In reception there is a PC, printer and phone, with assess to HICAPS/eftpos machine, Wifi and Cliniko practice management software.
Located at the intersection of Belmore Road, Coogee Bay Road and Avoca Street, the clinic is in the heart of this vibrant area with its banks, restaurants, cafes, supermarkets and independent stores all at arm's reach.
The clinic is close to a large number of buses services. There is also 1 & 2 hour parking available in the local area and 2 hr free parking within 2 min walk.
In 2018 the clinic will have a tram stop conveniently located across the road.
One month notice for cancellation is required. Rent is due on the 2nd of every month and paid in advance. One month deposit is required which is fully refundable.


Shortly after Apple kicked off preorders for the iPhone X on Friday, the company called on developer to submit updated apps that support the new device's advanced capabilities and unique design.
Posted to Apple's developer website, the call to action urges developers to code and test their updated app for full iPhone X compatibility ahead of next week's launch. Apple notes app makers can download Xcode 9.0.1 to take advantage of the built-in iPhone X simulator, useful for analyzing app performance without having access to actual hardware.
Apple touts major iPhone X features including the 5.8-inch Super Retina display, Face ID authentication, TrueDepth camera and more. Of interest to developers is compatibility with ARKit, Apple's framework for creating augmented reality apps. With the release of ARKit in iOS 11, Apple's iOS lineup becomes the world's largest augmented reality platform.
The new iPhone X also boasts an A11 Bionic chip designed for CoreML, a machine learning toolset, and Metal 2 graphics. These advanced APIs allow developers to take advantage of the phone's powerful processor, which features a dual-core neural engine.
Apple initiated iPhone X preorders early this morning, but demand quickly outstripped supply. About ten minutes after the system went live, all launch day supply was sold out. The device is now available with shipping estimates of 5 to 6 weeks.


In an era where everything is digital, Famasete has invested in what it considers to be the future of society: the "Smart Cities". These territories frequented by inhabitants and tourists are characterized by factors of intelligence and social sustainability, serving as the basis for parameters such as information technologies, environment, health, energy, mobility and urbanism.
To do this and thinking about progress and social welfare, Famasete has developed projects that are tailored to the needs of each citizen, who can take advantage of interactive public transportation stops, intelligent service stations, street furniture and outdoor advertising information, allies to the best interactive software.


text:
Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre
Mridula Laxman Bengre, M. Venkatraya Prabhu, S. Arun, Krishna Prasad, K. Gopalkrishna Bhat
Kasturba Medical College, Mangalore
Department of General Medicine, Kasturba Medical College, Mangalore
Background: Febrile neutropaenia prompts immediate hospitalization for its evaluation and the administration of empiric broad-spectrum antibiotics. It represents a major cause of morbidity, mortality and treatment costs in patients who receive chemotherapy. Risk stratification to identify the low risk patients is essential, as these patients may improve with outpatient treatment. This approach reduces the economic burden and thereby improves the quality of life. Objective: Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) score and also other factors for identifying the low risk febrile neutropaenic patients at a south Indian tertiary care centre. Materials and Methods: This is a prospective study which was done at a tertiary care hospital in Mangalore, from December 2009 to July 2011. The inclusion criteria were the histological diagnosis of malignancy, neutropaenia which was secondary to chemotherapy, an absolute neutrophil count of < 500/cumm3, oral temperature of >38.3°C or >38 °C for 1 hour and age > 13 years. The patients were stratified, based on the MASCC score. Other clinical laboratory parameters were explored for identifying the low risk patients. Results: A total of 50 cases of febrile neutropaenia were documented; 13 in solid cancers and 37 in haematological cancers. Acute leukaemia was the commonest underlying malignancy (26 out of 50). Seventeen cases were clinically documented, 16 cases were microbiologically documented and in 17 cases, no cause was found. Bacteraemia was the commonest (8 out of 16) among the MDI and E coli was the commonest organism which was identified (5 cases). All the patients were classified, based on the MASCC score. The association of the MASCC score and its outcome in terms of the recovery of the counts were found to be statistically significant (p <0.001). Other factors which were found to be statistically significant in identifying the risk of complications were; tachypnea rate> 24/minutes (p <0.001), Temperature>1020F (p= 0.049), hypotension (BP) value of <90/60 (p<0.001), ANC< 50/Cumm3 (p <0.001), deranged renal parameters (p=0.05), bacteraemia (p=0.001) and the inpatient status (p=0.006). Conclusions: The MASCC score correctly identifies patients with low risk febrile neutropaenia.
Clinical laboratories
Bengre, M. L., Venkatraya Prabhu, M., Arun, S., Prasad, K., & Gopalkrishna Bhat, K. (2012). Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre. Journal of Clinical and Diagnostic Research, 6(5), 839-843.
Bengre, Mridula Laxman ; Venkatraya Prabhu, M. ; Arun, S. ; Prasad, Krishna ; Gopalkrishna Bhat, K. / Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre. In: Journal of Clinical and Diagnostic Research. 2012 ; Vol. 6, No. 5. pp. 839-843.
@article{e3991ef75b54496ea03935d02acb2cb5,
title = "Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre",
abstract = "Background: Febrile neutropaenia prompts immediate hospitalization for its evaluation and the administration of empiric broad-spectrum antibiotics. It represents a major cause of morbidity, mortality and treatment costs in patients who receive chemotherapy. Risk stratification to identify the low risk patients is essential, as these patients may improve with outpatient treatment. This approach reduces the economic burden and thereby improves the quality of life. Objective: Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) score and also other factors for identifying the low risk febrile neutropaenic patients at a south Indian tertiary care centre. Materials and Methods: This is a prospective study which was done at a tertiary care hospital in Mangalore, from December 2009 to July 2011. The inclusion criteria were the histological diagnosis of malignancy, neutropaenia which was secondary to chemotherapy, an absolute neutrophil count of < 500/cumm3, oral temperature of >38.3°C or >38 °C for 1 hour and age > 13 years. The patients were stratified, based on the MASCC score. Other clinical laboratory parameters were explored for identifying the low risk patients. Results: A total of 50 cases of febrile neutropaenia were documented; 13 in solid cancers and 37 in haematological cancers. Acute leukaemia was the commonest underlying malignancy (26 out of 50). Seventeen cases were clinically documented, 16 cases were microbiologically documented and in 17 cases, no cause was found. Bacteraemia was the commonest (8 out of 16) among the MDI and E coli was the commonest organism which was identified (5 cases). All the patients were classified, based on the MASCC score. The association of the MASCC score and its outcome in terms of the recovery of the counts were found to be statistically significant (p <0.001). Other factors which were found to be statistically significant in identifying the risk of complications were; tachypnea rate> 24/minutes (p <0.001), Temperature>1020F (p= 0.049), hypotension (BP) value of <90/60 (p<0.001), ANC< 50/Cumm3 (p <0.001), deranged renal parameters (p=0.05), bacteraemia (p=0.001) and the inpatient status (p=0.006). Conclusions: The MASCC score correctly identifies patients with low risk febrile neutropaenia.",
author = "Bengre, {Mridula Laxman} and {Venkatraya Prabhu}, M. and S. Arun and Krishna Prasad and {Gopalkrishna Bhat}, K.",
Bengre, ML, Venkatraya Prabhu, M, Arun, S, Prasad, K & Gopalkrishna Bhat, K 2012, 'Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre', Journal of Clinical and Diagnostic Research, vol. 6, no. 5, pp. 839-843.
Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre. / Bengre, Mridula Laxman; Venkatraya Prabhu, M.; Arun, S.; Prasad, Krishna; Gopalkrishna Bhat, K.
In: Journal of Clinical and Diagnostic Research, Vol. 6, No. 5, 22.06.2012, p. 839-843.
T1 - Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre
AU - Bengre, Mridula Laxman
AU - Venkatraya Prabhu, M.
AU - Arun, S.
AU - Prasad, Krishna
AU - Gopalkrishna Bhat, K.
N2 - Background: Febrile neutropaenia prompts immediate hospitalization for its evaluation and the administration of empiric broad-spectrum antibiotics. It represents a major cause of morbidity, mortality and treatment costs in patients who receive chemotherapy. Risk stratification to identify the low risk patients is essential, as these patients may improve with outpatient treatment. This approach reduces the economic burden and thereby improves the quality of life. Objective: Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) score and also other factors for identifying the low risk febrile neutropaenic patients at a south Indian tertiary care centre. Materials and Methods: This is a prospective study which was done at a tertiary care hospital in Mangalore, from December 2009 to July 2011. The inclusion criteria were the histological diagnosis of malignancy, neutropaenia which was secondary to chemotherapy, an absolute neutrophil count of < 500/cumm3, oral temperature of >38.3°C or >38 °C for 1 hour and age > 13 years. The patients were stratified, based on the MASCC score. Other clinical laboratory parameters were explored for identifying the low risk patients. Results: A total of 50 cases of febrile neutropaenia were documented; 13 in solid cancers and 37 in haematological cancers. Acute leukaemia was the commonest underlying malignancy (26 out of 50). Seventeen cases were clinically documented, 16 cases were microbiologically documented and in 17 cases, no cause was found. Bacteraemia was the commonest (8 out of 16) among the MDI and E coli was the commonest organism which was identified (5 cases). All the patients were classified, based on the MASCC score. The association of the MASCC score and its outcome in terms of the recovery of the counts were found to be statistically significant (p <0.001). Other factors which were found to be statistically significant in identifying the risk of complications were; tachypnea rate> 24/minutes (p <0.001), Temperature>1020F (p= 0.049), hypotension (BP) value of <90/60 (p<0.001), ANC< 50/Cumm3 (p <0.001), deranged renal parameters (p=0.05), bacteraemia (p=0.001) and the inpatient status (p=0.006). Conclusions: The MASCC score correctly identifies patients with low risk febrile neutropaenia.
AB - Background: Febrile neutropaenia prompts immediate hospitalization for its evaluation and the administration of empiric broad-spectrum antibiotics. It represents a major cause of morbidity, mortality and treatment costs in patients who receive chemotherapy. Risk stratification to identify the low risk patients is essential, as these patients may improve with outpatient treatment. This approach reduces the economic burden and thereby improves the quality of life. Objective: Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) score and also other factors for identifying the low risk febrile neutropaenic patients at a south Indian tertiary care centre. Materials and Methods: This is a prospective study which was done at a tertiary care hospital in Mangalore, from December 2009 to July 2011. The inclusion criteria were the histological diagnosis of malignancy, neutropaenia which was secondary to chemotherapy, an absolute neutrophil count of < 500/cumm3, oral temperature of >38.3°C or >38 °C for 1 hour and age > 13 years. The patients were stratified, based on the MASCC score. Other clinical laboratory parameters were explored for identifying the low risk patients. Results: A total of 50 cases of febrile neutropaenia were documented; 13 in solid cancers and 37 in haematological cancers. Acute leukaemia was the commonest underlying malignancy (26 out of 50). Seventeen cases were clinically documented, 16 cases were microbiologically documented and in 17 cases, no cause was found. Bacteraemia was the commonest (8 out of 16) among the MDI and E coli was the commonest organism which was identified (5 cases). All the patients were classified, based on the MASCC score. The association of the MASCC score and its outcome in terms of the recovery of the counts were found to be statistically significant (p <0.001). Other factors which were found to be statistically significant in identifying the risk of complications were; tachypnea rate> 24/minutes (p <0.001), Temperature>1020F (p= 0.049), hypotension (BP) value of <90/60 (p<0.001), ANC< 50/Cumm3 (p <0.001), deranged renal parameters (p=0.05), bacteraemia (p=0.001) and the inpatient status (p=0.006). Conclusions: The MASCC score correctly identifies patients with low risk febrile neutropaenia.
Bengre ML, Venkatraya Prabhu M, Arun S, Prasad K, Gopalkrishna Bhat K. Evaluation of the Multinational Association for Supportive Care in Cancer (MASCC) Score for Identifying Low Risk Febrile Neutropaenic Patients at a South Indian Tertiary Care Centre. Journal of Clinical and Diagnostic Research. 2012 Jun 22;6(5):839-843.


Spaying or neutering your cat is important from a medical perspective and helps decrease unwanted behaviours. It also has a significant impact when it comes to controlling the unwanted (think stray and shelter) pet population. Medically speaking, intact (aka not spayed/neutered) males and females are at risk for certain forms of cancer. Intact females are also at risk for the life-threatening condition called pyometra, which is an infected uterus. Unspayed and unneutered cats can display unwanted behaviours such as urine spraying, late-night vocalization or roaming/breaking out to access a mate.
Unspayed female cats can go into heat very frequently, displaying these aforementioned behaviours each time. The stray/feral cat population is a very serious problem. Spaying and neutering cats have an exponentially positive impact on the unwanted pet population and help to reduce the public health concern. It also decreases the number of strays left to suffer illness in the absence of care and lessens the burden on local shelters and rescue organizations. Ask us about our wellness plans to help you budget for your cat's spay or neuter.
Spaying (females) and neutering (used for males) are surgical procedures that remove the reproductive organs. After this procedure, cats are no longer able to father or have kittens.
We recommend having your cat spayed or neutered at 6 months of age. As most cats have yet to reach sexual maturity before 6 months, having this surgery done after 6 months helps you avoid unwanted situations that arise from sexual maturities such as roaming/the risk of them becoming pregnant or impregnating a female, urine spraying in the home (males) and late-night vocalizations.
Your cat's surgery is a big deal to us, and we take great care to ensure you are well informed. Whether a spay or neuter, your cat will be admitted to our hospital first thing in the morning. Before surgery, the veterinarian will perform a complete physical examination to help determine if your cat is healthy enough to undergo the procedure. We strongly encourage pre-anesthetic bloodwork done the same morning and prior to surgery for all pets regardless of age. Blood work allows us to have a look at your cat's internal health and alerts us to any abnormalities that may impact how they handle anesthesia and surgery. With this information, we can determine the best plan for your cat's surgery.
During surgery, your pet is maintained on intravenous fluids, kept nice and warm and monitored closely on a variety of monitoring devices and most importantly, by a Registered Veterinary Technician. We are committed to keeping your pet as comfortable as possible to ensure pain management is a priority before, during and after surgery.
Surgeries are typically completed by early afternoon. A member of our team will contact you to let you know how your cat is doing and when you can expect them to be ready to go home. Discharge time is arranged to minimize the wait time for you and ensure we can review all home care needs in detail.


I was completely surprised and bewildered the other day when I receieved a text message telling me I was going to get a delivery.
That NEVER happens so I figured it was spam and forgot about it.
I won a free product coupon for a L'oreal Paris Healthy Look Creme Gloss hair color and it came this week!
Way cool - love getting goodies in the mail. I am expecting some leather cord in the mail this week - yeah!
OOOOOOO Cool prize. What did I get in the mail besides bills and advertisement... hmmmm Nope nothing really. Very boring mail lately, and my winning has slowed down considerably. :( Don't forget 4M today & theme is songs about money because today is tax end day! My favorite one I've seen so far is the one with Liza Minnelli & Joel Grey called, "MONEY" in the film Cabaret!
ohhhhh I wanna see the dress!!! I got a singing machine for my daughter's birthday....FUN!


text:
Tevez unable to explain absence
Ian Herbert
CARLOS Tevez failed to offer an explanation of his unauthorised absence in Argentina yesterday and played right into Roberto Mancini's hands by giving the manager every reason not to allow him to wear the Manchester City shirt again.
The striker has missed as many as four training sessions, having reported in with injuries, since he was told he would be forced to work with the reserves last month.
His failure to come anywhere near the level of Premier League match fitness, compounded by this week's disappearance to Buenos Aires, has left City increasingly confident that Mancini will be within his rights to make good on his promise that the player is "finished" at the club.
City had been deeply concerned by Article 15 of FIFA's regulations, which would entitle the player to terminate his contract next summer if he has not been given adequate playing time.
The club had briefed the manager on the regulation -- which could lead to a challenge from Tevez at the Court of Arbitration for Sport (CAS) -- and told him that he might have to give Tevez the equivalent of 10pc of the side's game time this season, effectively four full games.
But if Tevez remains at the club beyond January and continues his recalcitrance, City would argue in the strongest terms possible at CAS that he is not in the right physical state to be given that game time.
How he can have sustained new injuries preventing him maintaining a personal fitness regime is particularly baffling, considering that the demands of him in training are extremely limited.
There is little doubt that Mancini would be delighted to make good on his initial pledge that Tevez's City days were over, made in the aftermath of the club's Champions League match against Bayern Munich in September and the dispute over the player's role as a substitute. Though last week the manager held out the prospect of Tevez playing again if he said sorry, it was not an olive branch. Mancini was just seeking a way through a mess.
Tevez may have located one for him. FIFA regulations governing the status and transfer of players stipulate that the striker is entitled to terminate his contract under "sporting just cause" if he is effectively left to rot on the sidelines. But legal opinion yesterday supported City's view that Tevez's conduct may allow them to challenge his use of that clause.


Jemar Norpower AS has developed a quick fishing boat with excellent seaworthiness, large deck area for work and a top speed of app. 25 knots.
The boat is based on the hull from our new seismic workboats. The construction of the hull has been a success due to its stability and excellent seaworthiness.
Jemar Norpower AS 30ft quick fishing boat is 9,1 m in length and 3,30 m wide-ranging. This gives you a fishing boat with a large area on deck for work. Simultaneously will the construction of the hull, combined with the engine, give the fishing boat a cruising speed of 12-15 knots and a top speed of app. 25 knots! We recommend engines such as Cummins or Perkins from 300 to 500HK. The fishing boat has modern wheelhouse solutions, seating's and galley upstairs. Further, it will be equipped after customers demand.
The Hull: Fender list around the entire boat, new hull with V-shape, keel and tunnel that leads extra water into the propeller. Rescue Ladder of aluminium mounted behind the mirror on B/B side. All fittings are done in stainless executions. Stovepipes for cabin and exhaust in stainless steel. The wheel house is equipped with window of 10mm tempered glass, where the one is flexible for opening. Defroster on each window.
Railing in aluminum on wheelhouse roof. Height app. 30cm. Ø 30mm/ Ø25mm.
Modern fittings and intelligent solutions in wheelhouse giving space for small table, seating's and galley. The galley includes propane, 2 section cooking arrangement and sink. Fresh water from app. 20L tank with manual hand pump for filling sink. Drainage below fender.
Electrical equipment, 24 V included installation certificate.
Certificated lanterns: top and fishing lanterns, NUC in foremast, lantern for stern, two spotlight for deck on wheelhouse, lamp in wheelhouse, toilet and engine entry, two lamps in engine room and large converter, 24v DC&220v AC for electricity to lap top, Ipad etc.
Suburb and approved boards; Distribution panel of ampere- and voltmeter, separate lantern control with alarms. Spotlight, horn and wiper. Two set of battery: 1 à 180 Ah, 2 à 145 Ah. Hand bilge pump in engine room.
Gas fired, 2 section cooking arrangement.
Tank for hot water approximately 20 ltr. Recognized pumps for water and septic. Water toilet with electric pump, sink in the galley, and exhaust fans from galley and rest room.
Hydraulic side thruster with effectively 23, 7 HK mounted in a tunnel at the bow.
Windscreens in tarpaulin from hoop at mizzenmast to wheelhouse.
Pot haulers are placed in front, so the rear can come across the wheelhouse.
This for easy access to engine control /steering.
Fire extinguisher for engine room, powder extinguisher in steering house and at the entrance of engine room. Water Level alarm for engine room included. Non-blocking coating on deck, and places for naturally required safety. Rescue ladder back on B/B side.
The boat will go through extensive testing of engine and equipment's on board.


We want to restate this article is not a "be-all" "end-all" article that will solve every 'tactical' problem. It is written solely to introduce the concept of tactical movement to those with little experience or knowledge in this area. Theory and Reality are two different things; what works in the classroom will not always work in "life". Spotter Up will assume "no" responsibility for any use or misuse of information from this article. This article alone will not make the reader an expert in tactics or in firearms nor can it be used as a substitute for PROFESSIONAL TACTICAL TRAINING or WEAPONS TRAINING. Spotter Up advises you to visit our site for training courses with a certified instructor On ALL weapon platforms.
Circumstances are an attribute, detail, or condition with respect to time, place, manner, agent, etc., that accompanies, determines, or modifies a fact or event; it is a modifying or influencing factor. Keeping this in mind, know then, there are no fail safe entries. Every entry by units has pros and cons and there are far too many elements to list here. Trying to list every element would only cause more confusion. Practicing a technique will elicit the reasons why.
Single File Formation: This technique can be used if moving down a hallway. The size of the area, the number of personnel moving in a team and the items which require attention during movement (objects other than people, windows, doors, person (s)) dictates the speed and distance each *operator stands from another operator.
Security at the front is provided by the lead operator (red). Rear security is provided by the rear operator (orange). Any threat that appears forward of the lead operator must be handled by him. Any threat that appears at the rear of the team must be handled by the rear operator (orange). The remaining team members follow in a single file formation directly behind the lead operator. (red). The left and right sides of the lead operator are covered by the second and third man in the file (yellow, green). Any threats appearing from nearby doorways or windows on either side of the hallway must be addressed by each respective team member. The team must maintain security during the movement.
Pacing movement should be smooth and not an accordion-like effect with team members attempting to catch up with their partners. The leader sets the pace and should not get overwhelmed by overtaking his area and thereby degrading the effective coverage his flankers and rear security must provide. Too much stimuli can overwhelm team members; a danger from doing this is team members walking into the other's sector of fire; maintain your areas.
The single file technique can be used by small or larger teams. The single file technique might be the only option for teams to use when moving down narrow hallways. A heavy-headed formation (T-formation with 2-3 people in front) or double-file formation is best suited for wider hallways because men can spread out and walk shoulder to shoulder at the front of the file. The single file formation is restrictive and slow when opposing doors appear in view.
A ballistic shield can be used to great effect with the single file technique. The second or third man covering the left and right sectors may find their field of vision limited because of the position of the first man with his shield.
This is a very easy technique to maintain. Fire power and security are not optimal using this technique. The cartoon images below illustrate movement of the team (red arrow), items that require their attention (rear door and front doorway) but does not dictate how much gap is between members.
Double file movement will be covered in another article.
Images property of Spotterup. Please use as you want but please give Spotterup credit.


The best way to get to Bruges from London without wasting too much time is by flying into Brussels on a budget airline, or hopping on the Eurostar, and then making the last leg of travel between Brussels and Bruges by train. The cheapest way is to take a budget bus. Both Eurolines and FlixBus have direct buses from London to Bruges that take around 7 hours.
From Bruges Centraal station (also the bus stop, if you've arrived by bus), St Christopher's at The Bauhaus is a 25-minute walk or a 10-minute bus ride for just €3.00 (line 16 to Kruispoort). Stop off there first to check in, or if you've arrived before check-in time you can leave your luggage for free and head off to explore the city.
And because you're now in Belgium, your first stop has to be for waffles! A good friend of mine (who also works at The Bauhaus) swears by the waffle van that stands in Burg Square opposite the County Hall, and I have to agree that the waffles there are now my favourites too. Unfortunately the man who runs the van isn't there all the time, so take a walk down the small street that separates Burg Square from the Markt and treat yourself to a waffle from Chez Albert.
After devouring your first Belgian waffles in Bruges, it's time to walk it off! The climb to the top of the Bruges Belfry is a whopping 366 steps. But the exercise is worth it for the stunning view. Bruges is pretty flat, so it's one of the few chances you'll get to witness a rooftop view of the city.
Unfortunately, the one thing that's missing from the panoramic view of Bruges from the Belfry is a bird's eye view of the Markt below. So to watch the market in action (it runs every Wednesday) and cool off after your epic tower climb, head over to the Historium Museum. Entrance to the museum costs €13.50, but for a taste of Belgium's great beers and that view we were talking about, take the stairs to the first floor and enter Duvelorium. The bar has a panoramic terrace of the Markt, plus a great cheeseboard to accompany their €3.50 'beer of the month'.
Once you've tasted your first Belgian Beer, head back towards the Belfry and walk through the courtyard behind it. There are a few benches located around the edges of the courtyard, so it's a great place for people watching and photography! Coming out the other side, turn to your right and walk along Oude Burg.
En route you'll pass a lot of traditional Bruges townhouses (look out for the stepped triangular roofs!) and cafés. But don't stop until you get to Simon Stevenplein. Named after Simon Stevin, a famous mathematician and physicist born in Bruges, the square is surrounded by restaurants and quirky independent boutiques. It's a great place to grab a coffee in the evening, but as with most restaurants in Bruges the main meal prices are a little steep.
So once you're done taking in the energy of the square, continue in the same direction along Oude Burg to appreciate Sint-Salvatorskathedraal. Named after St Salvator, Bruges' Cathedral was built as a simple church in the 10th Century but was granted Cathedral status in the mid 19th Century.
Its dominating presence is best appreciated from the outside at sunset, after which dinner at Gran Kaffee de Passage is just a 3-minute walk away. Open until 10pm on weekdays and 11pm on weekends (it's closed all day on Mondays), de Passage is one of the few places in Bruges where you can eat a decent evening meal on a budget. Plates of pasta cost just under €15, and their lasagna is incredible.
The best way to see as much of Bruges in one day is by bicycle. So once you've tucked into your free breakfast at St Christopher's at the Bauhaus, rent one of their fabulous lime green bicycles for the day and head off towards the centre of the city. Warning: this part of the bicycle ride contains cobbled streets but the trip is too short to render your bum entirely numb.
Your first destination: Burg Square. After Markt Square, this is where most of the main attractions are located. But instead of heading straight into one of the more popular tourist attractions, head towards the Crowne Plaza Hotel. Hidden in the foundations of this hotel are the ruins of a 1,000 year old Cathedral: Sint-Donaaskathedraal. To see the ruins, first check at the reception. Sometimes the space is used for functions and closed off to the general public. But if it's not in use, access to the ruins is completely free and the reception staff will direct you straight to it. An incredible hidden gem, the ruins of St Donation's Cathedral isn't in most travel guides to the city so you should definitely take a step into the past here.
After exiting the Crowne Plaza, cross to the opposite corner of Burg Square where you will see a building that is in every travel guide to Bruges. But for good reason. The Basilica of the Holy Blood is a 12th Century Gothic Church that houses a relic that is incredibly important to the religious people of Bruges and pilgrims to the city.
On display twice a day (from 11.30am to midday and from 2pm to 4pm) is a vial that contains a cloth stained with the blood of Christ. Whether you believe or not, it's a humbling experience to be in the presence of a piece of history thought to date back almost 2,000 years.
Once you've had your taste of history it's time to explore picturesque Bruges, preferably with a camera in hand! The architecture in Burg Square makes for the perfect panorama photos, but taking a small passage between the Stadhuis and building of the Civic Registry will lead you to the Vismarkt.
Known as the location for Bruges' most traditional fish market, the square also houses local artists and their work. Many of whom will be selling original and sometimes abstract landscapes of Bruges' most famous location: Rozenhoedkaai. This road looks out over a particularly beautiful meander of the Dijver canal, framed on either side by two stone bridges and bursting with the colour of the green willows bending out from over the terrace of beer bar 2Be.
Continue to follow the canal until you reach Onze Lieve Vrouw (The Church of Our Lady), the gardens of which lead to the St. Bonifacius Bridge. It's the perfect bridge to sit and watch the canal boats pass underneath. Although you may be asked to move out of the way by photographers eager to grab a shot of the 'Bridge of Love'!
If you're not in the mood for romance and are in Bruges to sample great beer, then take a 2-minute cycle to Huisbrouwerij De Halve Maan. The De Halve Maan brewery dates back to the 16th Century, and has been run by the same family for the last 160 years! Two of Belgium's most famous beers, the Straffe Hendrik and the Brugse Zot, were created here. It's also a great place to grab a budget lunch, with their delicious take on the traditional soup of cheese and ham costing just €6.
Once you're full of beer, bread and cheese it's time to cycle it off! Heading South through Bruges from the Brewery will lead you to the city's ring road. Tucked in either side by beautiful parks, the road will lead you all the way around the outskirts of the medieval walls of Bruges. Make sure to pass by Minnewater Lake and the traditional windmills near the Kruispoort and the Bauhaus.
And our best suggestion for dinner is to stop by a supermarket and pick up a couple of bottles of beer, bread and any other foods you want to go with it. Throw it all into a backpack and once you find the most scenic spot en-route around the city, drop the bicycles and dig in!
Once it gets dark, head back to the hostel where the beer tasting experience takes place every night at 9.30pm. It costs €12, but it's well worth paying for considering the knowledge of the guide and the number of Belgian beers you get to taste.
After all the cycling on Day 2, begin your final day by taking a gentle walk through the back streets of Bruges towards the Blackbird Café. By far the cutest café in Bruges, it's breakfast is pretty expensive for those on a budget, but the coffee tastes just as good as it looks and is well worth the money.
If you have time before you leave the city, both the Frietmuseum (a museum about Belgian fries) and Choco-Story (Bruges' chocolate museum) are a short walk from the BlackBird Café. But if museums aren't your thing, head to the Princely Béguinage Ten Wijngaerde. A béguinage was traditionally a home for unmarried religious women who dedicated their lives to their faith.
To this day, nuns and unmarried women continue to live and worship in this peaceful enclosed space within the city walls. And it's only a 12-minute walk from the train station, making it the perfect sight to see before you head back to London.
Article and photos by Katie Dawes - a travel blogger and writer who tests out hostels all around the world. For more follow her blog The Hostel Girl.


Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.
Annu Rev Biochem. 2016 Jun 2;85:265-90. doi: 10.1146/annurev-biochem-060815-014857. Review.
Slowly progressing nucleotide excision repair in trichothiodystrophy group A patient fibroblasts.
Theil AF, Nonnekens J, Wijgers N, Vermeulen W, Giglia-Mari G.
Mol Cell Biol. 2011 Sep;31(17):3630-8. doi: 10.1128/MCB.01462-10. Epub 2011 Jul 5.
TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription.
Singh A, Compe E, Le May N, Egly JM.
Am J Hum Genet. 2015 Feb 5;96(2):194-207. doi: 10.1016/j.ajhg.2014.12.012. Epub 2015 Jan 22.
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
DNA Repair (Amst). 2011 Jul 15;10(7):697-713. doi: 10.1016/j.dnarep.2011.04.028. Epub 2011 May 14. Review.
Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.
Nishiwaki T, Kobayashi N, Iwamoto T, Yamamoto A, Sugiura S, Liu YC, Sarasin A, Okahashi Y, Hirano M, Ueno S, Mori T.
DNA Repair (Amst). 2008 Dec 1;7(12):1990-8. doi: 10.1016/j.dnarep.2008.08.009. Epub 2008 Oct 10.
A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.
DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17. Review.
Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia.
Moslehi R, Ambroggio X, Nagarajan V, Kumar A, Dzutsev A.
BMC Genomics. 2014 May 15;15:373. doi: 10.1186/1471-2164-15-373.
Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.
Zhou X, Khan SG, Tamura D, Ueda T, Boyle J, Compe E, Egly JM, DiGiovanna JJ, Kraemer KH.
Eur J Hum Genet. 2013 Aug;21(8):831-7. doi: 10.1038/ejhg.2012.246. Epub 2012 Dec 12.
DNA Repair (Amst). 2008 Feb 1;7(2):339-44. Review.
Role of XPD in cellular functions: To TFIIH and beyond.
Houten BV, Kuper J, Kisker C.
DNA Repair (Amst). 2016 Aug;44:136-142. doi: 10.1016/j.dnarep.2016.05.019. Epub 2016 May 16. Review.
Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH.
Hum Mol Genet. 2009 Oct 15;18(R2):R224-30. doi: 10.1093/hmg/ddp390. Review.
Trichothiodystrophy: from basic mechanisms to clinical implications.
Stefanini M, Botta E, Lanzafame M, Orioli D.
DNA Repair (Amst). 2010 Jan 2;9(1):2-10. doi: 10.1016/j.dnarep.2009.10.005. Review.
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Kuschal C, Botta E, Orioli D, Digiovanna JJ, Seneca S, Keymolen K, Tamura D, Heller E, Khan SG, Caligiuri G, Lanzafame M, Nardo T, Ricotti R, Peverali FA, Stephens R, Zhao Y, Lehmann AR, Baranello L, Levens D, Kraemer KH, Stefanini M.
Am J Hum Genet. 2016 Apr 7;98(4):627-42. doi: 10.1016/j.ajhg.2016.02.008. Epub 2016 Mar 17.
Seroz T, Hwang JR, Moncollin V, Egly JM.
Curr Opin Genet Dev. 1995 Apr;5(2):217-21. Review.
Genotype-phenotype relationships in trichothiodystrophy patients with novel splicing mutations in the XPD gene.
Botta E, Nardo T, Orioli D, Guglielmino R, Ricotti R, Bondanza S, Benedicenti F, Zambruno G, Stefanini M.
Hum Mutat. 2009 Mar;30(3):438-45. doi: 10.1002/humu.20912.
Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome.
Chiganças V, Lima-Bessa KM, Stary A, Menck CF, Sarasin A.
Cancer Res. 2008 Aug 1;68(15):6074-83. doi: 10.1158/0008-5472.CAN-07-6695.
Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair.
Zhu Q, Wani G, Sharma N, Wani A.
DNA Repair (Amst). 2012 Dec 1;11(12):942-50. doi: 10.1016/j.dnarep.2012.09.003. Epub 2012 Oct 17.
p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model.
Aguilar-Fuentes J, Fregoso M, Herrera M, Reynaud E, Braun C, Egly JM, Zurita M.
PLoS Genet. 2008 Nov;4(11):e1000253. doi: 10.1371/journal.pgen.1000253. Epub 2008 Nov 14.
Phenotype-specific adverse effects of XPD mutations on human prenatal development implicate impairment of TFIIH-mediated functions in placenta.
Moslehi R, Kumar A, Mills JL, Ambroggio X, Signore C, Dzutsev A.
Eur J Hum Genet. 2012 Jun;20(6):626-31. doi: 10.1038/ejhg.2011.249. Epub 2012 Jan 11.


text:
Raycho Tsonev (born 24 February 1936) is a Bulgarian athlete. He competed in the men's long jump at the 1964 Summer Olympics.

References

1936 births
Living people
Athletes (track and field) at the 1964 Summer Olympics
Bulgarian male long jumpers
Olympic athletes of Bulgaria
Place of birth missing (living people)

redpajama_set_name: RedPajamaWikipedia


text:
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var app = express();

app.use("/data", express.static( __dirname + "/build/chunks"));
// app.use("/", express.static( __dirname + "/html"));
app.use(express.static(__dirname + "/html"));

var rPort = Math.floor(7000);

app.listen(rPort, function()
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redpajama_set_name: RedPajamaGithub


Here's the thing...plants have a personality all their own. Hopefully what you see is what you get however when dealing with these living products, taking a picture and giving an accurate description of each plant can be challenging. Our experience may not necessarily be your experience. The French talk of 'terroir' when it comes to choosing a wine (how the vine and fruit are impacted by its environment) and let me submit to you that that is a concept similarly encountered when we choose a plant. How my or your planting experience may differ is how that plant is affected by the weather, the soil, where it is planted or how we have cared for our selection. So now maybe you can understand the difficulty we've had in describing each plant in our store! Our goal has been to give you enough information for a guideline, to encourage you to experiment, but your experience with it will be your own. How cool is that!! So please enjoy browsing and don't hesitate to send us any questions you may have.


text:
Q: Avoid custom cursor to disappear when reaching border of window I'm having a custom cursor (an svg arrow) in my page.
The problem comes when I reach the border of the browser/window with the limit of the image; it disappears and turns into a default cursor pointer.
Is there a way I can avoid the cursor to break/disappear when doing that?
Thanks

A: Please be sure your custom cursor is not greater than 32x32 px.
See https://stackoverflow.com/a/65032905

redpajama_set_name: RedPajamaStackExchange


The highly anticipated International Faith Conference (IFC), hosted by Bill Winston Ministries, began Sunday, Sept. 11 and lasts through Friday, Sept. 16 at Living Word Christian Center in Forest Park, IL.
Cash Luna returns for a third year to encourage, empower, and equip ministry leaders worldwide at the Leadership Summit, hosted by Faith Ministries Alliance. This multi-ethnic, multi-cultural Leadership Summit, which takes place on Thursday, Sept. 15 at Living Word Christian Center in Forest Park, IL, is an annual event held during Bill Winston Ministries' International Faith Conference.
Pastor Luna is founder and senior pastor of Casa de Dios, a 12,000-seat sanctuary in Guatemala, and is widely respected as a ministry leader, speaker and teacher, with several churches under his covering, including several churches here in the United States.
Well known throughout North, South and Central America, Pastor Luna's "Nights of Healing" crusades attract thousands of people who come for prayer and healing. Miracles at his crusades have been well documented. During the International Faith Conference, Pastor Luna will lead one of his healing services on Thursday evening.
Other Speakers include: Bishop Tudor Bismark, Kenneth Copeland, Dr. Jesse Duplantis, Rev. Samuel Rodriguez, Pastor Sheryl Brady, and conference hosts Drs. Bill and Veronica Winston. Simultaneous Spanish translation will be available.
All evening sessions are free and open to the public and will be live-streamed on www.billwinston.org. Children's Church, for ages 3-12 years, will be available on a first-come-first-serve basis. Attendees are asked to register at ifc.billwinston.org or call 1-866-816-4653.


After decades of R&D, numerous lessons learned, and limited initial adoption, gene therapy has finally become a clinically and financially viable option for certain indications globally. In the early 2000's, gene therapy was positioned at U.S. universities as promising, but largely experimental. In 2012, UniQure of the Netherlands gained EU approval for Glybera (world's first approved gene therapy), for the treatment of lipoprotein lipase deficiency. A few years following the approval of Glybera, our consultancy started to receive more inquiries to conduct competitive landscape assessments for gene therapy companies. The early therapeutic areas and indications were mostly in rare diseases and oncology, and these remain the focus areas today. Hemophilia B, ophthalmology, cystic fibrosis, and severe combined immune deficiency in children are some of the TA's and indications which also demonstrated early progress in the gene therapy space.
From recent conference research, we found that most clinicians in the EU had accepted gene therapy and were interested in participating in trials. However, the first generation of gene therapies in the EU were met with limited success, and the first four of ten approved therapies were eventually withdrawn, mostly due to hurdles with reimbursement. On face value, the attractiveness is clear; for example, picture this scenario for GSK's Strimvelis. You're a child with a rare, inherited disease, which requires injections at least once-a-month. You find the option to go to a treatment center in Milan, Italy with your family for an "all-inclusive" therapy regimen. It is costly, but after six weeks, if all goes as planned, you go home cured and do not have to take shots for the rest of your life. The word cure doesn't get used much these days when it comes to rare diseases and oncology, so when it does pop up, those who are connected take notice.
Cost continues to be an issue. Early drugs like Glybera cost one million euros, and were the world's most expensive drugs. In August 2017, the FDA, in what it called a "historic action," approved Kymriah, the first approval of a cell-based gene therapy in the United States. It was originally approved to treat children and young adults up to age 25 suffering from a form of acute lymphoblastic leukemia (ALL) who do not respond to standard treatment or have suffered relapses. Novartis set the one-time treatment price tag at $475,000 for patients who respond. Non-responders would not be charged. A couple of months later, Gilead's Yescarta was approved by the U.S. FDA to treat adults with large B-cell lymphoma, a type of non-Hodgkin lymphoma, who have failed to respond to other treatments. The price was set at $373,000, well below Novartis' chimeric antigen receptor T-cell therapy. CAR-T's reprogram the body's own immune cells to recognize and attack malignant cells. The cost debate continued in late 2017 and in January 2018, Spark Therapeutics set the price of Luxturna at $850,000 after receiving approval. Patient advocates argue that gene therapy prices will put stress on the U.S. healthcare system, with extreme predictions of bankrupting the system. Despite the criticism, pioneer manufacturers in pharma justify the cost by reminding customers of the cost and time spent to develop the drugs, and by stressing the one-time nature of treatment.
Other major biopharmaceutical players have taken notice. The most recent example is Celgene's acquisition of Juno in January 2018. The move was mainly made to gain access to JCAR017, a potentially best-in-class CD19-directed CAR-T which is expected to gain regulatory approval in 2019, with global peak sales of about $3 billion. Other companies, such as bluebird bio, Voyager Therapeutics, and Audentes Therapeutics, represent a growing sector of roughly 60 private and public companies working on therapies for upwards of 60 diseases, addressing market opportunities worth more than $100 billion (according to Barron's). While the momentum is clear, the regulatory, managed care, and patient advocacy elements will continue to present challenges for new entrants. The gene therapy space is hyper-competitive, and requires consistent monitoring and assessments of companies looking to shift the paradigm in medicine.
Below is an example of gene therapy, editing, and CAR-T companies in this competitive landscape: For more information about how to maintain a competitive advantage in gene therapy, please contact Cinda Steele via [email protected] or 610-496-0080. Landscape assessments, competitor deep dives, and scenario planning are all proven as effective tools to prepare for the gene therapy era, which has begun.
Competitive Intelligence: Tactical or Strategic?
We have been helping clients make strategic decisions with expert research and analysis since 1988. Our company history and culture revolve around the core values of ethical, aggressive, primary-driven intelligence.


text:
Wine Country growing pains hit home in Paso Robles
Food // Wine
Esther Mobley July 8, 2016 Updated: July 8, 2016 12:33 p.m.
This Feb. 2, 2010, photo shows Justin Vineyards and Winery in Paso Robles, a Central California winery hailed as one of the best in the country. It is seeing fallout after it clear-cut hundreds of old oak trees to make way for more vineyards.
Photo: Eric Risberg, Associated Press
Paso Robles looks like it's getting its first real dose of Wine Country growing pains.
The usually sleepy community in San Luis Obispo County jolted into a frenzy of controversy recently when Paso's Justin Winery cleared 100 acres of oak trees from a property on Sleepy Farm Road in order to construct a large reservoir to develop a vineyard there. It's a controversy whose themes will sound familiar to residents of Napa and Sonoma.
"We've never seen anything of this scale and magnitude," says Matt Trevisan of Linne Calodo Cellars, which is near the contested site. Trevisan discovered the oak removal on May 27 by happenstance while flying overhead in a helicopter. "I looked down and said, 'Whoa, what is happening here?'" he recalls. "It was startling." The before-and-after Google Earth images, now widely circulated, tell the whole story: lush, green forest before; bald, beige earth after.
Justin is possibly Paso Robles' highest-profile winery. In 2011, founders Justin and Deborah Baldwin sold the winery to the Wonderful Company — the luxury-ag corporation whose brands include Fiji Water, Pom juice and Wonderful Pistachios (remember the Stephen Colbert commercials?). Wonderful owners Stewart and Lynda Resnick (estimated net worth: $4.2 billion), who admit to violating their land-use permit, almost certainly incurred more wrath for the oak removal and reservoir construction than the average Paso landowner might have. The narrative was obvious: Beverly Hills billionaires invade Paso Robles, ruthlessly devastate forests and greedily gulp all of the West Side's water. (Paso has gotten just 13 inches of rain in the last 12 months.)
The community took to social media to condemn Justin's actions. Their voices were heard: On June 24, the Resnicks issued a formal apology. "We were asleep at the wheel," they wrote. "We are horrified by the lack of regard for both neighbor and nature that has been exhibited." As amends, they promised to dedicate the 380-acre property to conservation and plant 5,000 new oaks elsewhere.
Removing oaks on your property, by the way, is legal in Paso; Justin's permit violations hinged on the slope grading and the project's timing. But to the community, the gravity of the offense transcended its legality. Justin president David Ricanati concedes: "We've come to the conclusion that just because you can do something doesn't mean you should."
Justin Vineyard and Winery in Paso Robles (San Luis Obispo County) ignited a controversy after this June 7 aerial photo showed the Justin property where old oak trees were cleared to make room for vineyards and a reservoir.
Photo: Matt Trevisan, Associated Press
Amid the controversy, talks of an oak ordinance in Paso Robles have revived. To some, this is a puzzling development. "Paso Robles is known for being a bunch of rugged individualists," says Ancient Peaks Winery co-owner Doug Filipponi, whose family has been in Paso for generations. "We're renegades."
The property-rights impulse runs deep here, and historically it has often squashed proposals for sweeping land-use regulations. Past oak ordinances have failed. Just months ago, voters rejected the creation of a water district — fairly standard in parched areas of California — in (no pun intended) a landslide. The city of Paso Robles won't even join the county's library system.
But now, in the wake of the Justin scandal, it looks very likely that some form of tree ordinance will gain serious momentum.
"It all becomes very Ayn Randian," says Skylar Stuck, general manager of Halter Ranch Winery. "Be careful exactly what you want the government telling you to do on your property."
A cry for more regulation, a push for conservation, a backlash against vineyard development: The debate in Paso right now is starting to sound a lot like those that have dominated public discourse in Napa and Sonoma for decades.
For example, in Napa, a proposal by a large company to clear a forest for vineyard development — Hall Winery's Walt Ranch project — was recently "tentatively approved" after a decade of resistance. (Final word is expected at the end of July; appeals will almost certainly follow.)
"The scale of opposition has been surprising to me," says Hall president Mike Reynolds. Objectors claimed that Walt Ranch would clear too many trees, compromise the watershed and pose erosion concerns. The approved version of Walt Ranch represents at least a 33 percent reduction of Hall's original proposal. "Now, we're retaining more than 90 percent of the trees of the property, and at least 525 acres of woodland habitat is going to be placed in conservation easements," Reynolds says.
Napa Valley's regulation is particularly stringent: It has the country's first-ever agricultural preserve, established in 1968, which designates agriculture as "the highest and best use" of this special soil. Napa was heeding a cautionary tale: "When they did the ag preserve," explains Diane Dillon, a Napa County supervisor, "it was because they were looking at Santa Clara Valley."
Before it became Silicon Valley, Santa Clara was a leading fruit producer, in both quality and quantity. "Santa Clara had luscious, beautiful soil for growing fruit, worldwide acclaimed fruit," says Dillon. San Jose was the world's largest center of dried-fruit packing and canning prior to World War II. Only in the 1950s did another of its natural resources — silicon — begin displacing orchards as the county's defining industry. In 1949, the crop report lists 81,780 harvested acres of fruit trees in Santa Clara County; in 2014, just 1,208 were harvested. The apricot tree — once that valley's signature, its Cabernet Sauvignon — took up 18,266 acres in 1949, and just 203 in 2014.
Napa's ag preserve was insurance against this path. But it has also made grape-growing in Napa a more convoluted and bureaucratic enterprise than anywhere in the country.
In Paso, the Resnicks' project on Sleepy Farm Road may have been opportunistic — its sub-AVA, Willow Creek, can produce beautiful wines — but in Napa, expansion today is mostly driven by an exhaustion of options. There's simply nowhere left to go. The valley virtually is planted to capacity, so vineyard development creeps to hillsides, which carry a distinct set of concerns from the valley floor — especially erosion — and must answer to the ag preserve and watershed.
As renegade Paso contemplates this oak ordinance, Napa Valley confronts a fully realized tension between those who believe its agriculture is over-regulated and those who believe it is under-regulated. New resorts going up in Calistoga have residents worried about water use — but cities like Calistoga depend on transient occupancy taxes from tourists. Traffic on Highway 29 has residents in an uproar — but the allure of tasting wine in Napa generates $13 billion for the county every year. Can you have your cake of a peaceful bucolic existence and eat the financial rewards too?
More By Esther Mobley
By Esther Mobley
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At the heart of Napa's dilemma, now in messy post-pubescence, and Paso's own problem, still in its infancy, is this: The land gets protected because it is valuable. But the more valuable it gets, the greater the financial temptations are to develop it.
The Resnicks themselves are a barometer of value. "When the Resnicks purchased Justin, it was a sign that Paso Robles has become a very serious wine region," says Kevin Sass, Halter Ranch's winemaker (and a former Justin winemaker, under the Baldwins' ownership). "But at the same time, it brought in larger corporations that might not know how our community has always operated."
One contingent's sentiment: Can't we just work it out on our own? "But trusting that everyone will do the right thing is probably not an adequate development policy," says Jason Haas of Tablas Creek Winery.
Others point out that clearing trees in Paso isn't exactly a novelty. Long ago, vineyards displaced walnut orchards, apple orchards, open cattle land. "There's a lack of perspective," says Jim Irving, a local real estate broker and county planning commissioner. "When you drive around, you see a lot of trees that have double and triple trunks — trees that were all clear-cut 100 years ago, when Paso had a charcoal plant."
But the Resnicks come with more baggage: They're big, and they're not locals. At the same time, their power means increased publicity — and increased value — for the region as a whole. Ricanati offers a gentle reminder: "We're proud to be out on the road talking about Paso Robles all over the country. We're an ambassador in New York, Chicago, Miami."
Are these growing pains inevitable? Or do they suggest a model of wine-region development that is somehow untenable in contemporary, resource-scarce California?
"I'm a property-rights person," says Trevisan. "But if you don't do something, there won't be any property to protect."
Absent land-use regulations, do you go the way of Santa Clara Valley?
"I doubt that you will see any more oaks cleared for a hundred miles now," says Filipponi. "And now, hopefully, Justin will make it right, and we'll go back to doing what we do, which is trying to make a living in the wine business."
Esther Mobley
Follow Esther on:
https://www.facebook.com/SFChronicle/esther_mobley
Wine critic Esther Mobley joined The Chronicle in 2015 to cover California wine, beer and spirits. Previously she was an assistant editor at Wine Spectator magazine in New York, and has worked harvests at wineries in Napa Valley and Argentina. She studied English literature at Smith College.
For the first time in 25 years, Americans are drinking less wine
'I'm deeply ambivalent': Winemaker Randall Grahm sells influential Bonny Doon winery
Why this wine critic is not doing Dry January
Algerian eatery Kayma is one couple's American Dream in San Francisco
Alice Waters teams up with UC Davis for new Institute for Edible Education
Devil's Teeth Baking Company to open second San Francisco location
For Ethiopian-inspired honey wine, dock at San Francisco's Ferry Building


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The women's 500 m time trial at the UEC European Track Championships was first competed in 2014 in Guadeloupe, France.

Medalists

References

Women's 500 m time trial
Women's time trial (track cycling)


Abstract: We present in this paper a coincidence theory for maps with closed graph and maps with continuous selections. Our theory relies on a new fixed point theorem for maps with closed graph. In addition, new minimax theorems and variational inequalities are presented.
Electronic fulltext finalized on: 7 Aug 2001. This page was last modified: 9 Nov 2001.


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It marked a new chapter for The Democratic Republic of Congo as new President Felix Tshisekedi took the oath of office at the presidential palace in Kinshasa on the 24th of February. The inauguration ceremony saw an end to former president Joseph Kabila's 18-year term.
Cheers and jubilation rocked the DRC's capital that Thursday afternoon as supporters of the incoming president celebrated their victory, which followed a long awaited and grueling electoral process. Elections were initially slated for December 2016, but had since been postponed severally.
But with the country still reeling from contested outcomes of the elections, what can be expected of President Tshisekedi's first term? And what more does the future hold for the DRC, in the aftermath of its historic change of guard?


text:
Salivary Glanular Changes in Avitaminosis as in Rats
Foreign Technology Division Wright-Patterson AFB United States
Khudoyarov,I.
Bobkov,A. G.
In avitaminosis-A in the salivary glands of rats the following changes were noted A lagging in the growth and differentiation atrophy of the glands, which are most pronounced in the submaxillary gland degenerative-necrotic changes in the epithelium of the ducts and to a lesser degree of the acini and scaling of the epithelium cells into the lumen of the ducts. In some cases, the alteration of the walls of the ducts led to a flow-out of the secretion into the stroma. Inflammation, apparently connected with the accompaniment of infection, was also observed. Proliferation and metaplasia of the epithelium of the ducts into a multilayer plane cornifying epithelium were noted. In one case stones were formed in the lumen of the ducts of the parotid gland, along with stones in the bladder with the presence in the parotid gland of metaplasia of the epithelium and a change in the composition of the secretion. The formation of stones, apparently, depended on the combination of a number of causes and conditions, both of a general and local character.
METABOLIC DISEASES
CALCULI


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As Ramadan Begins, Secretary-General Urgently Calls on All Sides to Cease Hostilities in De-Escalation Area of Syria
SG/SM/19567
The following statement was issued today by the Spokesman for UN Secretary-General António Guterres:
The Secretary-General is following with great concern the intensifying hostilities in the de-escalation area of north-western Syria involving Syrian Government forces and their allies, armed opposition forces and Hayat Tahrir al‑Sham. He is alarmed by reports of aerial attacks on population centres and civilian infrastructure resulting in hundreds of civilian dead and injured and over 150,000 newly displaced persons.
On 5 May, three health facilities were reportedly hit by air strikes, bringing the total to at least seven struck since 28 April. Nine schools have reportedly been hit since 30 April, and schools in many areas have been closed until further notice.
The Secretary-General urges all parties to uphold international humanitarian law and protect civilians. He calls for an urgent de-escalation of the situation as the holy month of Ramadan begins and urges the parties to recommit fully to the ceasefire arrangements of the memorandum signed on 17 September 2018. He urges the Astana guarantors to ensure that this takes place.


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Der Jogltisch ist ein Bauernmöbel, das überwiegend aus Fichten-, Rotföhren- oder Rotbuchenholz gefertigt wird.

Als "Rhöntisch" ist er auch in der Rhön, dem Mittelgebirge im Dreiländereck Hessen, Bayern, Thüringen, bekannt und dort auch noch anzutreffen.

Die Tischplatte ist meist verschiebbar; darunter angebracht sind zahlreiche Fächer, eine Brotlade und eine zusätzliche Bestecklade. Knapp über dem Boden befindet sich eine Trittleiste (Vergeltsgott genannt), die den Zweck hatte, die Füße vor der Kälte des Bodens zu schützen. Auch wurde sie verwendet, um beim Familiengebet darauf zu knien.

Herkunft und historische Bedeutung
Der Jogltisch, auch Jokeltisch genannt, wurde ursprünglich im Joglland, einer waldreichen Mittelgebirgsgegend in der nördlichen Steiermark, gebaut und um die Mitte des letzten Jahrtausends von einem Mönch des Augustiner-Chorherrenstiftes Vorau erstmals geschichtlich erwähnt.

Kulturelle Bedeutung
Der Jogltisch stellte in der bäuerlichen Familie stets den Mittelpunkt des sozialen Lebensraumes dar. Unweit der Feuerstelle oder des Herdes diente er auch als Kochstelle. Auf dem Jogltisch wurde gegessen, an ihm zusammengesessen, gefeiert, getrauert, geredet, gebetet und Verträge abgeschlossen. Da viele bäuerliche Familien damals oft über keine Schränke und Kästen verfügten, wurden wichtige Dokumente und Gegenstände gerne unter der verrückbaren Tischplatte verwahrt.

Ein interessantes literarisches Beispiel findet sich in einer Erzählung des österreichischen Schriftstellers Peter Rosegger, der eine Szene am Jogltisch wie folgt beschreibt: "Der Nachbar saß am Tisch, schnitt sich aber nichts vom Brot und wollte von einem gütlichen Vergleich nichts wissen. Da stemmte sich mein Vater an die Tischplatte, diese gab nach und schob sich über das darunter liegende Fach hinweg. Nun zog mein Vater aus den vielen sorglich zusammengebundenen Papieren, die im Gelasse waren, ein Blatt hervor und sagte 'Wirst eh selber drauf unterschrieben sein' und legte es dem Nachbarn vor. Dieser studierte das Schriftstück kurz und zog kleinlaut von dannen. Mein Vater schob die wuchtige Ahornplatte wieder zurück und von dem Tag an wußte ich, wo das Urkundenarchiv des Hauses war."

Der Jogltisch heute
Heute zählen originale Jogltische zu den absoluten Raritäten, sind sehr teuer und werden nur selten angeboten. In einigen historischen Höfen kann man allerdings noch solche Tische bewundern. Auch bieten einige Tischler heute Nachbauten des Jogltisches an, da sich gerade in den letzten Jahren ein Trend in Richtung traditioneller Wohnkultur abzeichnet.

Weblinks & Quelle
 Jogltisch.at | Das Jogltisch Lexikon (abgefragt am 21. Dezember 2013)
 BeyArs Kunstlexikon (abgefragt am 21. Dezember 2013)
 Austria-Forum

Tisch
Joglland


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Costa Rica trials hydrogen bus
Hydrogen powered bus
Costa Rica has begun test driving its first hydrogen fuel cell bus as the country moves towards using 100 per cent renewable energy.
As many motor manufacturers are developing electric cars, hydrogen is seen as even cleaner and benefits from using the most abundant resource in the universe.
The hydrogen is taken from water by passing electricity through it, often sourced from solar or wind generators. It is then mixed with atmospheric oxygen to generate an electric current which drives a motor.
Juan Ignacio Del Valle, a rocket engineer with Ad Astra, the company behind the project said a lot of work had gone into the technology.
"In this plant renewable energy from the solar panels and the wind turbine is turned into hydrogen gas inside the station," he explained.
"The gas is then pumped into the bus, which is stored into tanks, and then whenever the bus needs to move, gas is turned back into electricity that drives the electric motors. The only by-product is pure water."
The Costa Rican President Luis Solis unveiled the hydrogen bus project and is says he is optimistic.
"Today is an historic day in Costa Rica with the first bus to use hydrogen in its engine. This is an occasion when Costa Rica affirms its will to move towards zero carbon emissions."
The electric bus project cost more than 3 million euros. First rides will be in Liberia next June.


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Dickey's Barbecue Pit®:
Dickey's Barbecue Pit Brings Back Free Delivery
By: Dickey's Barbecue Pit® | 1 Shares 50 Reads
World's largest barbecue concept offers essential options via website and app
July 17, 2020 // Franchising.com // DALLAS - Dickey's Barbecue Pit fans can now easily enjoy authentic, Texas-style barbecue favorites in the comfort of their homes because the world's largest barbecue concept is bringing back free contactless delivery on Dickeys website and the Dickey's App this week.
In addition, the 79-year-old Texas-born barbecue joint is offering special deals for guests this summer, including its Two 2 Meat Plates for $24, 10% off catering orders of $100 or more and Kids Eat Free Sunday. Dickey's deals are all available for free contactless delivery, pickup, carryout and dine-in where available.
"As new COVID-19 cases emerge, we want our guests to have dining options wherever they feel the most comfortable," said Laura Rea Dickey, CEO of Dickey's Barbecue Restaurants, Inc. "It's our promise to provide a safe experience while providing convenient and quality family meal opportunities."
To support first responders keeping communities safe during this time, Dickey's is offering a limited-edition collectible Big Yellow Cup. The barbecue franchise is donating a portion of the proceeds from each First Responder Tribute Cup sold to The Dickey Foundation, which provides safety equipment such as helmets, shields, respiratory masks and overall support for local first responders.
About Dickey's Barbecue Restaurants, Inc.
Dickey's Barbecue Restaurants, Inc., the world's largest barbecue concept, was founded in 1941 by Travis Dickey. For the past 79 years, Dickey's Barbecue Pit has served millions of guests Legit. Texas. Barbecue.™ At Dickey's, all our barbecued meats are smoked onsite in a hickory wood burning pit. Dickey's proudly believes there's no shortcut to true barbecue and it's why they never say bbq. The Dallas-based, family-run barbecue franchise offers several slow-smoked meats and wholesome sides with 'No B.S. (Bad Stuff)' included. The fast-casual concept has expanded worldwide with two international locations in the UAE and operates over 500 locations in 44 states. In 2016, Dickey's won first place on Fast Casual's "Top 100 Movers and Shakers" list and was named a Top 500 Franchise by Entrepreneur in 2018. Dickey's Barbecue Pit has also been recognized by Fox News, Franchise Times, The Wall Street Journal, QSR Magazine, Forbes Magazine and Nation's Restaurant News.
SOURCE Dickey's Barbecue Restaurants, Inc.
Dickey's Barbecue Pit®
Dickey's Barbecue Restaurants, Inc., the nation's largest barbecue chain was founded in 1941 by Travis Dickey with the goal of authentic slow smoked barbecue.


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What are the new Covid rules coming into force in England on Monday?
14:28, September 09 171 0 theguardian.com
Less than two months ago, Boris Johnson unveiled a plan to set the country on a path to a "more significant return to normality" by Christmas. But now, with fears of a difficult few months ahead amid rising Covid-19 cases, Downing Street is clamping down on social interactions to avoid a second national lockdown.
On Monday, new measures come into force in England in a bid to control the spread of the virus. So, just what are the new rules and how will they be enforced?
What will be illegal under the new rules?
From Monday, gatherings of more than six people inside or outside in England will be illegal, with some exemptions. Under present rules for England, guidelines limit most gatherings to six people, or no more than two households or support bubbles, but the law has allowed for a higher limit of 30 people. "You must not meet socially in groups of more than six and if you do, you will be breaking the law," Johnson told a Downing Street press conference on Wednesday, dubbing it "the rule of six".
What does this mean if a family of five wants to visit two grandparents at the same time?
In short, doing so would be illegal as this would mean seven people were gathering. Asked about the issue on Wednesday, the health secretary, Matt Hancock, told BBC Breakfast: "I'm afraid for a family of five or six, this will bring in some significant restrictions, I get that and we don't do this lightly." He added: "I have three children, we have a family of five, and so we'll be able to see one other person at a time as a whole family."
Are there exemptions?
Yes, quite a few. For instance, if a family who live together – or a support bubble – is already larger than six they will not be in breach of the law by being together but they will not be able to see anyone else as a group. Places of worship, gyms, restaurants and hospitality venues can still hold more than six people in total. But within those venues, Johnson highlighted, there must not be individual groups larger than six and groups must not mix socially with others. Education and workplaces are also exempt. Covid-secure weddings and funerals can still take place with up to 30 people, as well as organised team sports.
Why is the government doing this now?
The number of Covid-19 cases are rising fast, with the R number – the average number of people one person infects – above 1 although it is not clear what the exact figure is. There have been nearly 8,500 positive Covid-19 tests recorded in England in three days. There is particular concern in government over the growth in infections among young people. The weekly rate of cases per 100,000 people across the population is 19.7 but it is significantly higher among younger people. For 17 to 18-year-olds it is 48.1, for 19 to 21-year-olds it is 54.5 and across the age range of 20 to 29 it is 41.6. The rates for younger children and older people remain broadly flat.
What about those who break the new rules?
The new measures are designed to simplify the rules to help police enforcement, with rule-breakers facing a £100 for the first offence. Fines will double on each further offence, up to £3,200. Covid-secure marshals will be introduced to boost local authority enforcement.
Gatherings limited to six in England to curb Covid-19, says PM – video
The new rules will be in place for the "foreseeable future", Hancock told BBC Radio 4's Today programme on Wednesday, although he said he hoped the situation could be turned around before Christmas. Later, Johnson clarified that the measures would be kept under review and only continue for as long as necessary. "These measures are not another national lockdown," he said, adding: "The whole point of them is to avoid a second national lockdown."
What else is the government doing?
The government is making it a legal requirement for pubs and restaurants to take customers' details and keep them for 21 days for the NHS test-and-trace programme, which has until now been voluntary. Businesses who fail to do so will face fines.
The passenger locator form, designed to aid tracing efforts, which arrivals are required to fill out before the enter the country, is being simplified, Johnson said. He also said there would be measures to ensure these were completed and checked before departure. It comes after the Guardian revealed that Border Force officials only aim to check less than a third of arrivals for passenger locator forms. Johnson said Border Force would be stepping up enforcement to ensure arrivals were complying with quarantine rules.
The prime minister also indicated there could be further restrictions on the opening hours of venues in some areas, after a similar move this week in Bolton – which is suffering the highest Covid rates in the country – where pubs and restaurants have to shut from 10pm to 5am. "We will also restrict the opening hours of premises, initially in some local areas," Johnson said, without specifying where this could to place.
Will plans to allow fans back into sports stadiums and other venues still go ahead?
Johnson said the plans would be reviewed. He said: "At the present time, I'm afraid we must also revise plans to pilot larger audiences in venues later this month and review our intention to return audiences to stadiums and conference centres from the 1st of October. That doesn't mean we're going to scrap the programme entirely, we just have to review it and abridge it."
New York doctor accused of sexually abusing patients faces federal charges
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Damage done by Tories' disregard for rule of law
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This Brexit bill finally buries the Conservative party of law and order
'Demagogue' tells the story of Sen. Joseph McCarthy's rise and fall
The US Capitol riot risks supercharging a new age of political repression
US death row prisoner Dustin Higgs petitions Trump for clemency
Lawyer calling for Dominic Cummings investigation forced to move after attacks on home
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The Society interview Robert Rinder: 'Law is meaningless unless everybody has access to it'
Protest exemption set to be removed from England lockdown rules


WealthPartners, LLP, recently announced one promotion and two newhires. Delynn Oliver has been promoted to financial services assistant. Oliver has been with the company for almost five years working in the area of marketing and insurance support. A Mississippi State University graduate, she is now primary investment and insurance support.
Angie Artman joined the firm in May 2010, and is involved in business development and executive assistant functions. She received her B.S. in fitness management from Mississippi State University and M.B.A. in finance from Mississippi College.
Tisha Burland Koury also joined the firm in May 2010, and she is working part-time as an administrative assistant. Koury is a former business owner in the Jackson and Fairhope, Ala., areas. She received her B.A. in public relations/speech communications from Auburn University.


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Wild Portals Megaways Slot Review
Posted on March 8, 2022 by Admin in Gambling
Big Time Gaming has established a solid reputation, and their contributions to the industry have had a significant impact on the development of new slot games in recent years. The Megaways engine has accomplished this, though the creator has demonstrated that it can continue to innovate and that this was not a one-hit wonder. The latest game they're working on called Wild Portals Megaways, and it looks like we're in for something special once again.
Wild Portals Megaways is a 6-reel slot with a maximum payout of 117,649 Megaways. Since it's expected to be able to pay up to 116,030x the stake in a single round, it'll make far greater use of those various ways and characteristics. Not only is this one of the highest-paying slots available, but it also boasts a high RTP of up to 96.58 percent, so the increased volatility is tolerable. There's plenty to keep you busy inside, with Wild Portals, scatters, cascading reels, multipliers, free spins, and the Win Exchange.
Prizes and Betting
It won't be the most generous betting range, but because this is such a risky game, a bet of up to $20 will usually suffice. The minimum stake that can be placed is $0.20.
Let's now have a look at the prizes that Wild Portals Megaways could offer. This is where the game really shines, as a single spin can pay as much as 116,030x the stake. There are other options to aid you in your quest, but few other positions come close to matching that level of potential.
Despite its high volatility, the game appears to be a good choice for players, as seen by its 96.58 percent Return on Investment.
Features of the Wild Portals Megaways Slot
The typical Megaways slot has six reels on which two to seven symbols might appear. Each reel's number is chosen at random, allowing for a wide range of scenarios and arrangements. If all seven reels have seven symbols on them, you can win up to 117,649 times.
Although it isn't quite a normal wild symbol, the Portal Wild serves a similar purpose. It occupies four locations, all of which are 2×2 positions, and it may be found on the middle four reels (2-5).
Wilds first serve as substitutes, assisting as much as possible, before being employed as gateways to bring in one of the lower-paying symbols. All symbols of that type are removed from the game, and others are added. Each time this happens, the Portal's multiplier increases by one.
Wild Portals Megaways can award 8 to 14 free spins when three or more scatters appear. You can use any Wild Portal that was present in the triggering spin, and you'll always get a new one each time. Another plus is that the Portal's multiplier increases rather than resetting.
You can pay for the free spins to be activated, but you must first win at least 75 times your stake. You pay that amount in exchange for the feature, which comes with eight rounds. The Win Exchange is what it's called.
Design & Theme
The concept of the gateway is evident in the slot's design, especially as a gate bearing the W emblem will appear in the gaming area. Big Time Gaming, on the other hand, doesn't put as much work into the other aspects of the design as they do in their other games. In general, don't expect to be wowed by the offer in this scenario.
Six Royals are offered as symbols at first, followed by 9 to A. Then we go on to some rather uninteresting gemstones that are dyed and carved in a variety of ways (blue, green, red, purple).
It's another fantastic Megaways slot machine from the engine's original inventors. They rose to prominence as a result of the innovation they brought to the online casino business, and they continue to strive to outdo themselves with each new slot.


Put the flour and butter in a food processor and blend until the mixture resembles fine breadcrumbs.
Add the egg and pulse until the mixture just comes together as a dough.
Bring the dough together and flatten into a round shape.
Take the cauliflower florets, oil, onions and korma paste and mix together thoroughly in a bowl.
Tip into pre heated roasting tray and roast in 200°C oven for 30 mins, when cooked with colour set aside to cool.
Add the potatoes, the spinach leaves and roast cauliflower mix , season with nutmeg, salt and freshly ground black pepper. Mix all the ingredients together until well combined.
Spoon the filling mixture into the pastry case. Pour over the cream and allow it to drizzle down between the layers. Sprinkle the garam masala on top. Place the tin on a baking tray and bake in Preheat the oven (200°C/180°C (fan)/Gas 6).
Bake in the oven for 40-45 minutes, or until the pastry is crisp and pale golden-brown.


Member: Arkansas Bar Association and Pulaski County Bar Association.
Mickel Law Firm, P.A. offers a comprehensive array of services for the mortgage default industry throughout the states of Arkansas, Tennessee, Mississippi & Texas.


All SYCAMORES homes currently listed for sale in West Jordan as of 04/18/2019 are shown below. You can change the search criteria at any time by pressing the 'Change Search' button below.
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