text:
The new Ferrari F8 Spider is a blockbuster
The new Ferrari F8 Spider is a blockbuster with ferrari Ferrari's most successful mid-rear V8 engine in ferrari history as a new generation of convertible sports cars.
The new Ferrari F8 Spider has a design concept that is interoperable with the F8 Tributo, while the new model features a leaphorse brand's compact and efficient Retractable Hard Top foldable hard-top convertible, perfectly shaping beautiful body lines to be the best in its class.
The new F8 Spider model is the newest member of the Ferrari Ferrari V8 Cabriolet family, which dates back to the 308 GTS model, which came out in 1977.
It may not be as high as the different tone of the 488 Pista Spider, but the new F8 Spider has a better and more powerful sporty performance and driving feel than the previous model, the 488 Spider.
The F8 Spider combines the strongest V8 engine in the history of the brand with unparalleled driving pleasure, providing a fun-filled driving experience for the owners of the Leap Horse with superior practicality and superior handling, and successfully setting up a new standard for the convertible model. The F8 Spider's V8 turbo engine has won the International Engine of the Year award for four consecutive years in 2016, 2017, 2018 and 2019 .
Year, even among the many equally award-winning competitors of the past, has won the "Best of the Best" award, setting an unbeatable winning record in the history of the awards and setting an incomparable benchmark for car and engine manufacturers around the world. The highlight of the new F8 Spider is its powerful, real-time instant power, which, with out the slightest turbo delay, also features the V8 engine's unique sound waves.
Its exceptional performance and easy-to-enjoy handling are thanks to a range of innovative aerodynamic designs developed from track experience. Ferrari Ferrari builds every new model with a combination of innovative design and a comprehensive optimization and upgrade based on previous models. Leap horse engineers and designers often face different challenges, not only to develop innovative and forward-looking vehicle design, set a higher standard of excellence, but also to break the limits of creation and expand the boundaries of technology.
The advent of the new F8 Spider symbolizes Ferrari's once again overcoming challenges and transcending itself. As a successor to the 488 Spider, the new F8 Spider offers a complete improvement in all performance parameters. The F8 Spider has an output of 50cv and a weight reduction of 20 kg compared to the previous model. The F8 Spider also weighs just 20kg compared to the 488 Pista Spider, which has peak performance. In addition, the new car significantly improves aerodynamic efficiency, while also using the latest SSC 6.1 version of the side-slip angle control system.
Ferrari's V8 engine has become a perfect example of the perfect combination of sporty performance and driving pleasure around the world, a perfection that is even more evident in two-seater models with a rear engine configuration.
For more than 40 years, Ferrari Has been constantly improving the performance of its mid-rear engine, hoping to deliver an unparalleled driving experience through optimal weight balance. The Ferrari Ferrari V8 engine has outstanding performance parameters. At 8000 rpm, the exhaust volume of the engine of 3,902cc has an output of up to 720cv and a power factor of a staggering 185cv/l.
The peak torque is also improved by the readjustment: at a speed of 3250 rpm, the peak torque can reach 770 Nm. Ferrari's V8 engine is a masterpiece of modern craftsmanship. The V8 engine on the Ferrari F8 Spider also delivers the outstanding qualities of Ferrari's engine range and upgrades it to deliver an acceleration experience that is not dull and extremely smooth.
Not only that, but the engine sound waves are even more unique with the help of the new exhaust system. The F8 Spider benefits from the perfect combination of vehicle dynamic design, instant power reaction and excellent handling. Perfect for the driver's pure driving pleasure and passion.
The FDE-Ferrari Dynamic Reinforcement System Upgrade, which can be activated in RACE mode, allows the driver to easily ride the sports car while also giving the best possible performance. The F8 Spider's engine has a 50cv power upgrade compared to the 488 Spider thanks to a new intake channel from the 488 Challenge model. In addition, its engine air intakes move back from both sides of the body to the rear spoiler and are directly connected to the gas container, which not only significantly reduces energy loss, but also allows more air flow to be introduced into the engine, effectively enhancing the power output.
The spoiler is then specially designed to significantly increase dynamic air pressure, further introducing more air into the engine.
The F8 Spider automatically adjusts the high-performance start function via the Adaptive Performance Launch to analyze ground conditions and use the most torque dissomuchently transmitted by the electronic control system to match the road grip, minimizing wheel slips and achieving optimal acceleration performance.
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The wall effect of the speed limiter also makes the engine's extreme performance leap forward, and when the speed reaches the limit of 8000 rpm, the speed is stopped immediately when it is stopped, rather than gradually limiting the speed when approaching the limit, which facilitates ensuring maximum power output and effectively increasing lap speed in the event of intense driving. Ferrari Ferrari's highly regarded Variable Torque Torque Torque Progressive Torque management system is also in use on this model and is suitable for all gears. The torque curve is newly designed to highlight the extreme sports performance of the new car, resulting in the ultimate smooth acceleration performance. The engine's peak torque is also 10 nm higher than the 488 Spider, and even in the lower speed ranges it is even better.
The new F8 Spider engine follows the Ferrari 488 Pista's highly lightweight design, which reduces weight by up to 18 kg in its power unit compared to the 488 Spider and rotates and non-tempo weights by reducing parts such as titanium linkages, crankshafts and flywheels to quickly increase engine speed. This creates an adrenaline-fuelled driving experience. Especially in the case of tight operation such as shift shift ingress and low gear rapid acceleration, the driver can clearly see the needle on the tachometer spinning rapidly.
This more perfect dynamic lightweight design has succeeded in reducing engine inertia by 17%. In addition, the F8 Spider successfully reduced its engine by 9.7 kg by using a chrome-nickel ferroalloy exhaust manifold from the 488 Challenge models. The entire exhaust system, including turbochargers and exhaust tailpipes, is heavily updated to produce unique engine sound waves. At the same time, the engine tone is also very recognizable, in the volume intensity and tone quality have reached a new level.
The exhaust pipe is also equipped with a new petrol particulate filter (GPF) to meet the new certification requirements.
The new Ferrari F8 Spider, hand-crafted by the Ferrari Styling Centre Ferrari Design Centre, follows the F8 Tributo design style, perfectly illustrating the avant-garde design concept of the strong performance inherent in the Leap Horse brand and ultimate aerodynamic efficiency. When designing an open-top sports car, the choice of convertible is particularly important in the overall shape of the model.
For comfort reasons, Ferrari Ferrari's convertibles have been designed with hard-top convertibles in recent years, as have the Ferrari F8 Spider, and the model's contoured line design is based on a foldable hard-top convertible. The key to the design is to move the body and roof of the line from the traditional waistline position (approximately to the passenger's shoulder position) to the rear of the B-pillar, making the convertible look more refined.
In addition, the convertible is divided into two parts when folded and placed one by one in the position above the engine. At speeds below 45 km/h, the foldable hard top convertible can be easily opened or closed in just 14 seconds.
Ferrari Styling Centre Ferrari Design Centre defines the design objectives of the F8 Spider, which is based on the F8 Tributo design evolution, while drawing inspiration from the most iconic V8 sports car in the history of the brand with a mid-engine configuration to create the F8 Spider, paying tribute to the Ferrari Ferrari Classic V8 engine. The design draws inspiration from advanced aerodynamic sins to give the new car a more distinctive example of sports and personality.
The design draws inspiration from advanced aerodynamic sins to give the new car a more distinctive example of sports and personality. After the introduction of the S-Duct aerodynamic channel, the front of the model was redesigned and a series of aerodynamic innovations were introduced.
For example, the new car is equipped with a new, more compact horizontal LED headlights. The rear spoiler has also been redesigned. The enlarged spoiler covers the tail light, visually lowering the vehicle's center of gravity, while restoring the classic double-circle lamp shape and the design of the same color as the rear and body.
These are important features of the early Ferrari Berlinetta V8 models, and the legendary model, the 308 GTB, is the perfect example of this design. The bonnet design is one of the most distinctive design elements of the F8 Spider model.
The central bulge lines start from the rear window and extend all the way under the wing of the active spoiler, and the overall design is consistent with the air diversion direction, outlining a sharp and aggressive shape. The two winged designs, extended from the center, blend perfectly with the body design, resulting in a smooth visual aesthetic. The floating wing design has vents underited to help improve the engine's cooling. In addition, the three stereo-cutting slits on the side of the bonnet also help the engine dissipate, while the iconic rear window design of the Coupe model is preserved.
The black-coated cut not only has a lightweight design, but also makes the overall shape of the new car more recognizable. The protruding crown design at the rear of the cockpit cover bends and extends back into the spoiler, like a swan-necked tail frame common in F1 racing, while symbolizing the sporty nature of the F8 Spider.
The new F8 Spider cockpit design retains the classic driver-centric design of the berlinetta models in the rear engine configuration and is designed to provide the ultimate driving experience such as the F1 racing man."
The new steering wheel incorporates all the control buttons and the sports seats are newly designed. Underneath the circular air outlet in the center of the instrument panel is an aluminum sail panel that extends to the dashboard. To create a simple and lightweight visual feel, the new car uses a carbon fiber trim to separate the upper and lower parts, highlighting the streamlined overall cockpit design.
In addition, the dashboard includes a Ferrari Classic with a central tachometer and an optional 7-inch passenger-side touch screen.
Under the dashboard is a separate channel, further enhancing the simple design of the new interior." This channel features a new suspended bridge design with a three-dimensional feel, highlighting the streamlined style of the cockpit.
Aerodynamic design
The Ferrari F8 Spider models follow the experience that the Leap Horse brand has accumulated in GT races and the Ferrari Challenge Ferrari Challenge, and use the innovative technologies specially developed by Ferrari Ferrari for these races.
As a result, this medium-rear engine-built, high-volume convertible provides the ultimate in performance for drivers with different driving experiences. Unlike the 488 Spider, the F8 Spider features a backward-tilted front radiator that facilitates cooling at the bottom of the body, but also reduces the surface area at the bottom of the body that provides downforce, so designers redesign the geometry of the hot air channel that effectively drains the hot air channel. To ensure maximum downforce. At the same time, the positive effect between the air flow from the radiator and the front wheel reduces its resistance. As a result, vehicle performance is 10% higher than the 488 Spider.
Dynamic performance
The F8 Spider is more powerful, the body is lighter, the aerodynamic efficiency is further advanced, and overall performance is significantly higher than that of the 488 Spider. To make it easy for more leap-horse owners to experience the extraordinary performance of the Ferrari F8 Spider, Ferrari engineers are equipped with the latest vehicle dynamic control system in addition to improving the engine performance and aerodynamic efficiency of the models. In addition, the SSC vehicle side-slip control system has been further upgraded to enhance the driver's control over the vehicle during extreme driving, creating a more exciting driving experience.
From SSC 6.0 to SSC 6.1, the FDE-Ferrari Dynamic Reinforcement System Upgrade is integrated in RACE mode. FDE Ferrari Dynamic Reinforcement System, first used in the 488 Pista models, then used in the 488 Pista Spider models, this lateral dynamic control system precisely adjusts the braking power on the brake calipers through software, compared to the original system, the Ferrari F8 The Tributo models are equipped with an additional feature, and this upgraded system is also available on the F8 Spider models. Prior to the upgrade, the FDE Ferrari Dynamic Reinforcement System will only start when the vehicle is overandened and out of the bend (not in braking conditions), while the upgrade will allow the FDE-Ferrari Dynamic Reinforcement System Upgrade to operate at low-grip and also start in RACE mode.
Seven-year original plant maintenance plan
Based on stringent quality standards and a customer-oriented approach to service, the Ferrari F8 Spider models provide regular maintenance services for owners for up to seven years. The seven-year original plant maintenance plan is available to all Leap Horse models and covers all regular routine maintenance for the first seven years after sale. The program is Ferrari Ferrari's exclusive customer service to ensure that every Ferrari Customer's car remains at the highest level of safety and performance.
Owners of used cars can also enjoy this exclusive service. Directly trained in the professional services team at the Ferrari Training Centre Ferrari training centre in Maranello Maranello, the professional services team uses modern and state-of-the-art overhaul equipment for rigorous routine maintenance (every 20,000 km, or once a year without mileage), original parts and other inspections.
Ferrari Ferrari customers around the world can enjoy this service through Ferrari Ferrari's official dealer network. The Genuine Maintenance original maintenance program aims to further expand Ferrari's after-sales service to meet the needs of the owners and maintain the optimum performance and superior quality of each Leap Horse sports car, which is the hallmark of all Leap Horse sports cars. Ferrari has become synonymous with cutting-edge technology and sports cars.
FF8 Spider Specifications
Type 90-degree V8 twin-turbo engine - dry oil pan
Total exhaust 3,902 cc
Maximum output power: 720cv (530kW) - 8,000 rpm
Peak torque s 770 cattle s m s 3250 rpm
Power factor 185 cv/l
Maximum speed 8000 rpm Compression ratio 9.6:1
Body length 4,611 mm
Body width 1,979 mm
Body height 1,206 mm
Front wheel pitch 1,677 mm
Rear wheel pitch 1,646 mm
Dry weight s 1,400 kg
Weight Distribution Top 41.5% - Rear 58.5%
Luggage capacity 200 litres
Tank capacity 78 liters
Front round 245/35 ZR 20 J9.0
Rear wheel 305/30 ZR 20 J11.0
Front wheel 398 x 223 x 38 mm
Rear wheel 360 x 233 x 32 mm
7-speed F1 dual clutch transmission
E-Diff3, F1-Trac, Ferrari Ferrari Pre-Fill High Performance ABS/EBD,
FrS SCM-E, FDE plus, SSC 6.1
0-100 km/h 2.90 seconds
0-200 km/h 8.2 seconds
Fuel consumption/CO2 emissions
In certification
:: No.98 Octane Petrol Optional
This post was last modified on September 16, 2019 4:18 am
Dreamer is what I am, but unlike many, I struggle to make my dreams come true. I own, seo, admin and site editor. I am a father, married, Christian, Northeastern/Brazil and Libran. I love cars <3
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text:
Contact and CV
Benjamin Hughes is an independent arbitrator with The Arbitration Chambers in Singapore and Fountain Court Chambers in London. He has been appointed as arbitrator in over 100 arbitrations with a total value in dispute in excess of USD 2 billion, including ad-hoc arbitrations and arbitrations under the rules of the following arbitral institutions (in alphabetical order):
ACICA (Australian Centre for International Commercial Arbitration)
AIAC (Asian International Arbitration Centre (formerly KLRCA)
BAC (Beijing Arbitration Commission)
CAA (Chinese Arbitration Association (Taipei)
CIETAC (China International Economic and Trade Arbitration Commission)
DIS (German Arbitration Institute)
HKIAC (Hong Kong International Arbitration Centre)
ICC (International Chamber of Commerce)
ICDR (International Centre for Dispute Resolution
JCAA (Japan Commercial Arbitration Association)
KCAB (Korean Commercial Arbitration Board)
LMAA (London Maritime Arbitration Association)
SCC (Arbitration Institute of the Stockholm Chamber of Commerce)
SCMA (Singapore Chamber of Maritime Arbitration)
SIAC (Singapore International Arbitration Centre)
UNCITRAL (UN Commission on International Trade Law (ad-hoc and administered)
VIAC (Vietnam International Arbitration Centre).
Ben has also acted as emergency arbitrator and as sole arbitrator in expedited and fast-track proceedings and is a panel arbitrator of numerous arbitral institutions.
Ben's experience as arbitrator spans a broad range of commercial disputes, including joint venture and shareholder disputes, intellectual property and licensing, media and telecommunications, construction and infrastructure projects, energy and resources, shipping and shipbuilding, automobile and heavy machinery manufacturing, agency and distributorship agreements, military acquisition and procurement contracts, sale of goods and general commercial disputes.
Ben has been appointed as arbitrator in cases seated in Bangalore, Beijing, Delhi, Geneva, Guam, Hamburg, Hanoi, Hong Kong, Kuala Lumpur, London, Manila, Maui, New York, Seoul, Singapore, Stockholm, Sydney, Taipei and Tokyo. He has heard cases governed by the laws of Australia, Austria, BVI, Cayman Islands, China, England and Wales, Fiji, France, Germany, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Mauritius, Mongolia, the Philippines, Saudi Arabia (including Sharia), Singapore, Sweden, Switzerland, Taiwan, the United States (including New York, California and US territories) and Vietnam, as well as lex mercatoria. He has also handled complex conflict of law and jurisdictional issues, joinder applications, summary dismissal applications and disputes involving multiple contracts and applicable laws.
Ben has taught extensively in the field of international dispute resolution and comparative law, including as associate professor at Seoul National University Law School (2015-2019), and as a visiting professor at the University of Hong Kong Faculty of Law and the National University of Singapore Law School. He has published numerous articles on international commercial arbitration and serves on the editorial boards of the Asian International Arbitration Journal, the Korea Arbitration Review and the Journal of Korean Law.
Prior to commencing his practice as an independent arbitrator, Ben was the founding co-chair of the international dispute resolution practice group at Shin & Kim, one of Korea's oldest and largest full-service law firms. He previously practised international arbitration at Shearman & Sterling in the US and Singapore and at Kim & Chang in Seoul.
Ben was educated in both the civil law and the common law traditions, having studied first at Seoul National University College of Law (all coursework in Korean), and then at NYU School of Law. While at NYU, he spent one semester at the University of Palermo Law School in Buenos Aires, Argentina (all coursework in Spanish). He also studied Chinese (Mandarin) and East Asian history at Harvard University. He is a fellow of the Chartered Institute of Arbitrators, the Hong Kong Institute of Arbitrators and the Singapore Institute of Arbitrators.

redpajama_set_name: RedPajamaCommonCrawl


text:
using osu.Framework.Localisation;

namespace osu.Game.Localisation
{
    public static class TabletSettingsStrings
    {
        private const string prefix = @"osu.Game.Resources.Localisation.TabletSettings";

        /// <summary>
        /// "Tablet"
        /// </summary>
        public static LocalisableString Tablet => new TranslatableString(getKey(@"tablet"), @"Tablet");

        /// <summary>
        /// "No tablet detected!"
        /// </summary>
        public static LocalisableString NoTabletDetected => new TranslatableString(getKey(@"no_tablet_detected"), @"No tablet detected!");

        /// <summary>
        /// "Reset to full area"
        /// </summary>
        public static LocalisableString ResetToFullArea => new TranslatableString(getKey(@"reset_to_full_area"), @"Reset to full area");

        /// <summary>
        /// "Conform to current game aspect ratio"
        /// </summary>
        public static LocalisableString ConformToCurrentGameAspectRatio => new TranslatableString(getKey(@"conform_to_current_game_aspect_ratio"), @"Conform to current game aspect ratio");

        /// <summary>
        /// "X Offset"
        /// </summary>
        public static LocalisableString XOffset => new TranslatableString(getKey(@"x_offset"), @"X Offset");

        /// <summary>
        /// "Y Offset"
        /// </summary>
        public static LocalisableString YOffset => new TranslatableString(getKey(@"y_offset"), @"Y Offset");

        /// <summary>
        /// "Rotation"
        /// </summary>
        public static LocalisableString Rotation => new TranslatableString(getKey(@"rotation"), @"Rotation");

        /// <summary>
        /// "Aspect Ratio"
        /// </summary>
        public static LocalisableString AspectRatio => new TranslatableString(getKey(@"aspect_ratio"), @"Aspect Ratio");

        /// <summary>
        /// "Lock aspect ratio"
        /// </summary>
        public static LocalisableString LockAspectRatio => new TranslatableString(getKey(@"lock_aspect_ratio"), @"Lock aspect ratio");

        private static string getKey(string key) => $@"{prefix}:{key}";
    }
}

redpajama_set_name: RedPajamaGithub


text:
Displaying publications 1 - 20 of 72 in total
Fulltext Incidence of Helicobacter pylori Infection using (13) C- Urea BreathTest and Gastric Biopsy Culture
Khairul, A.J., Anwar, A., Ramelah, M.
International Medical Journal Malaysia, 2007;6(2):1-8.
Background: (13) C – urea breath test (UBT) is sensitive and specific for detection of Helicobacter pylori (H. pylori) infection. Gastric biopsy culture for H. pylori confirms the diagnosis. Here, we analyzed data of all patients who were investigated for H. pylori infection using both tests throughout the year 2005. Materials and Methods : Retrospective data of 377 patients between the ages of 17 – 88 were identified through endoscopy records from January to December 2005. Upper endoscopy, UBT and gastric biopsy culture were performed on all patients simultaneously during each endoscopy session. Patients who had positive UBT and biopsy culture for H. pylori were treated with triple therapy of PPI, amoxicillin and clarithromycin for one week. A repeat of UBT was done at one-month post therapy. Results and Analysis: Twenty-eight patients on the list had no available data on UBT and were omitted from the analysis. Ethnic group Chinese comprised of 45.4% (n=163), followed by Malay, 37.3% (n=134), Indian, 10.6% (n=38) and others, 3.9% (n=14). UBT was positive in 23.7% (n=85)(figure1). H. pylori culture was positive in 19.2% (n=69)(figure1). Sixteen patients with UBT positive had H. pylori culture negative, 18.8% (n=16/85)(figure2). Five patients with H. pylori culture positive had UBT negative, 7.2% (n=5/69)(figure3). Ethnic group Indian had the highest incidence of UBT positive, 47.4% (n=18/38), followed by Others (Sikhs and foreigners) 42.8% (n=6/14), the Chinese 27.6% (n=45/163) and the Malays 11.6% (n= 16/138). UBT positive was the highest in the age group of 50 and above, 64.7% (n=55/85), followed by the age group between 30 to 49, 21.2% (n=18/85) and the age group of 29 and below, 14.5% (n=12/85). Out of the 85 UBT positive patients 91.8% (n=78/85)(figure4) of them responded to the conventional one week of triple therapy (PPI, amoxicillin, clarithromycin) with negative UBT at one-month post therapy compared to only 8.2% (n=7/85)(figure4) who failed with positive UBT at one-month post therapy.
Acanthamoeba keratitis: current status and urgent research priorities
Khan NA, Anwar A, Siddiqui R
Curr Med Chem, 2018 May 10.
PMID: 29745319 DOI: 10.2174/0929867325666180510125633
BACKGROUND: First discovered in the early 1970s, Acanthamoeba keratitis has remained a major eye infection and presents a significant threat to the public health, especially in developing countries. The aim is to present a timely review of our current understanding of the advances made in this field in a comprehensible manner and includes novel concepts and provides clear directions for immediate research priorities.
METHOD: We undertook a search of bibliographic databases for peer-reviewed research literature and also summarized our published results in this field.
RESULTS: The present review focuses on novel diagnostic and therapeutic strategies in details which can provide access to management and treatment of Acanthamoeba keratitis. This coupled with the recently available genome sequence information together with high throughput genomics technology and innovative approaches should stimulate interest in the rational design of preventative and therapeutic measures. Current treatment of Acanthamoeba keratitis is problematic and often leads to infection recurrence. Better understanding of diagnosis, pathogenesis, pathophysiology and therapeutic regimens, would lead to novel strategies in treatment and prophylaxis.
Importance of Theranostics in Rare Brain-Eating Amoebae Infections
Anwar A, Siddiqui R, Khan NA
ACS Chem Neurosci, 2019 01 16;10(1):6-12.
PMID: 30149693 DOI: 10.1021/acschemneuro.8b00321
Pathogenic free-living amoebae including Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri cause infections of the central nervous system (CNS), which almost always prove fatal. The mortality rate is high with the CNS infections caused by these microbes despite modern developments in healthcare and antimicrobial chemotherapy. The low awareness, delayed diagnosis, and lack of effective drugs are major hurdles to overcome these challenges. Nanomaterials have emerged as vital tools for concurrent diagnosis and therapy, which are commonly referred to as theranostics. Nanomaterials offer highly sensitive diagnostic systems and viable therapeutic effects as a single modality. There has been good progress to develop nanomaterials based efficient theranostic systems against numerous kinds of tumors, but this field is yet immature in the context of infectious diseases, particularly parasitic infections. Herein, we describe the potential value of theranostic applications of nanomaterials against brain infections due to pathogenic amoebae.
Future Priorities in Tackling Infections Due to Brain-Eating Amoebae
ACS Chem Neurosci, 2017 11 15;8(11):2355.
Brain-eating amoebae (Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri) can cause opportunistic infections involving the central nervous system. It is troubling that the mortality rate is more than 90% despite advances in antimicrobial chemotherapy over the last few decades. Here, we describe urgent key priorities for improving outcomes from infections due to brain-eating amoebae.
Fulltext Combating Acanthamoeba spp. cysts: what are the options?
Anwar A, Khan NA, Siddiqui R
Parasit Vectors, 2018 01 09;11(1):26.
PMID: 29316961 DOI: 10.1186/s13071-017-2572-z
Acanthamoeba spp. are protist pathogens and causative agents of serious infections including keratitis and granulomatous amoebic encephalitis. Its ability to convert into dormant and highly resistant cysts form limits effectiveness of available therapeutic agents and presents a pivotal challenge for drug development. During the cyst stage, Acanthamoeba is protected by the presence of hardy cyst walls, comprised primarily of carbohydrates and cyst-specific proteins, hence synthesis inhibition and/or degradation of cyst walls is of major interest. This review focuses on targeting of Acanthamoeba cysts by identifying viable therapeutic targets.
Fulltext Galactose as novel target against Acanthamoeba cysts
PLoS Negl Trop Dis, 2019 07;13(7):e0007385.
PMID: 31348789 DOI: 10.1371/journal.pntd.0007385
Anomalous aortic origin of a coronary artery (AAOCA): A case report
Anwar A, Chan KMJ, Awang Y, Ping DC
Med J Malaysia, 2019 Oct;74(5):436-438.
Anomalous Aortic Origin of a Coronary Artery (AAOCA) is a rare anomaly of the coronary artery with a considerable risk of sudden cardiac death due to ischaemia of the heart. Symptoms may include chest pain on exertion, breathlessness or dizziness. We encountered a case of a 46- year-old female who complained of exertional chest pain with a positive-stress test and subsequently diagnosed with AAOCA through CT angiography (CTA). She successfully underwent a coronary artery bypass graft (CABG) surgery using a saphenous vein graft with uneventful recovery. Right internal mammary artery (RIMA) was not used as it was flimsy and the flow was very poor.
Repurposing of Drugs Is a Viable Approach to Develop Therapeutic Strategies against Central Nervous System Related Pathogenic Amoebae
ACS Chem Neurosci, 2020 08 19;11(16):2378-2384.
Brain-eating amoebae including Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris cause rare infections of the central nervous system that almost always result in death. The high mortality rate, lack of interest for drug development from pharmaceutical industries, and no available effective drugs present an alarming challenge. The current drugs employed in the management and therapy of these devastating diseases are amphotericin B, miltefosine, chlorhexidine, pentamidine, and voriconazole which are generally used in combination. However, clinical evidence shows that these drugs have limited efficacy and high host cell cytotoxicity. Repurposing of drugs is a practical approach to utilize commercially available, U.S. Food and Drug Administration approved drugs for one disease against rare diseases caused by brain-eating amoebae. In this Perspective, we highlight some of the success stories of drugs repositioned against neglected parasitic diseases and identify future potential for effective and sustainable drug development against brain-eating amoebae infections.
Workplace Cyberbullying and Interpersonal Deviance: Understanding the Mediating Effect of Silence and Emotional Exhaustion
Anwar A, Kee DMH, Ahmed A
Cyberpsychol Behav Soc Netw, 2020 May;23(5):290-296.
PMID: 32282237 DOI: 10.1089/cyber.2019.0407
Workplace cyberbullying (WCB) is a new form of hostility in organizations in which information technology is used as a means to bully employees. The objective of this study is to determine the association between WCB and the interpersonal deviance (ID) of victims through parallel mediation through the ineffectual silence of employees and emotional exhaustion (EE). Conservation of resource (COR) theory and affective events theory were used as the study's guiding framework, and data were drawn from 351 white-collar employees who were employed in a variety of industries-such as banking, telecommunications sector, education, health care, insurance, and consultancy-in Lahore, Pakistan. The results show that ineffectual silence negatively mediated the relationship between cyberbullying and deviance, decreasing the level of deviance of employees who used silence as a coping mechanism. EE, however, positively mediated the relationship between cyberbullying and deviance. This means that when employees felt emotionally overwhelmed they retaliated by engaging in deviant behaviors and acting as a bully toward colleagues. Drawing on the COR theory and the affective events theory, the findings show that WCB has an impact on ID. From a practical standpoint, the study reveals that WCB can lead to ID and it also may associate with large financial costs and workplace disruptions. Thus, organizations should establish a culture that prevent employees from engaging in WCB and adopt practices of prevention and intervention because it is not only harmful to the employees but also to the organization.
Fulltext Mechanisms of Colorectal Cancer Cell Growth and Metastasis Inhibition By Carp-1 Functional Mimetic-4
Abdelkader E. Ashour, Anwar A. Almuslim, Sheikh F. Ahmad, Sabry M. Attia, Rehan Ahmed, Ashok Kumar, et al.
IIUM Medical Journal Malaysia, 2019;18(102):44-0.
Colorectal cancer (CRC) constitutes one of the most aggressive malignancies worldwide and in Malaysia. Due to high recurrence rate and toxic side effects associated with radiation and chemotherapies, new agents are urgently needed. CARP-1 is a peri-nuclear phospho-protein which plays a dynamic role in regulating cell growth and apoptosis. CARP-1 functional mimetics (CFMs) are a class of compounds that stimulate CARP-1. CFM-4, a lead compound, was shown to suppress growth and metastasis of various cancers, other than CRC. We hypothesized that CFM-4 inhibits proliferation and metastasis in CRC. Materials and method: CFM-4 anti-cancer effects of on CRC cells were investigated using MTT assay, Annexin V/Propidium iodide (PI) apoptosis assay, cell cycle analysis, quantitative real-time PCR (qRT-PCR) and Western blotting. Antimetastatic activities were assessed by migration, colony formation and invasion assays. Results: CFM-4 inhibited CRC cell proliferation and was much more potent than the classical anti-CRC 5-fluorouracil. These effects were shown to be mediated at least in part by stimulating apoptosis, as indicated in our Annexin V/PI assay results. Cell cycle analysis showed that CFM-4 induced G2/M phase arrest. Molecularly, qRT-PCR results revealed that CFM-4 promoted intrinsic apoptosis by upregulating expression of caspase-8 and -9 , p53, PUMA and Noxa, and stimulated extrinsic apoptosis by enhancing expression of death receptors (DR4 and DR5). CFM-4 upregulated NF- k B signaling inhibitor A20-binding inhibitor protein and the PI3K negative regulator PTEN. Western blot analysis results revealed that CFM-4 enhanced expression of CARP1, caspase-8 and executioner caspase-3. Metastatic properties of the CRC cells were reduced by CFM-4 through blocking their capabilities to form colonies, migrate and invade through the matrix-coated membranes. Conclusion: The potent antitumor and anti-metastatic properties of CFM-4 against CRC are due to collective pro-apoptotic, anti-proliferative and anti-metastatic activities. Together our data warrants further investigations of CFM-4 as potential anti-tumor agent for CRC malignancy and metastasis.
Fulltext An open label comparative study of glimepiride versus repaglinide in type 2 diabetes mellitus Muslim subjects during the month of Ramadan
Anwar A, Azmi KN, Hamidon BB, Khalid BA
Med J Malaysia, 2006 Mar;61(1):28-35.
PMID: 16708731 MyJurnal
This study was conducted to compare the treatment efficacy between a prandial glucose regulator, repaglinide and a new sulphonylurea, glimepiride in Muslim Type 2 diabetic patients who practice Ramadan fasting. Forty-one patients, previously treated with a sulphonylurea or metformin, were divided to receive either repaglinide (n=20, preprandially three-times daily) or glimepiride (n=21, preprandially once daily) 3 months before the month of Ramadan. During Ramadan, patients modified their eating pattern to two meals daily, and the triple doses of repaglinide were redistributed to two preprandial doses. Four point blood glucose monitoring were performed weekly during the month of Ramadan and the subsequent month. Measurements of the 4-point blood glucose were significantly lower in the glimepiride group compared to the repaglinide group both during and after Ramadan. The glycaemic excursion was better in the morning for the repaglinide group and better in the afternoon and evening for the glimepiride group during the Ramadan period. There was no statistically significant difference in the incidence of hypoglycaemia between the two groups during and after Ramadan. There was no difference in the glycaemic excursion post-Ramadan. The longer duration of action of glimepiride may offer an advantage over repaglinide during the 13.5 hours of fast in Ramadan for diabetic patients.
Fulltext Cytotoxic effects of Benzodioxane, Naphthalene diimide, Porphyrin and Acetamol derivatives on HeLa cells
Jeyamogan S, Khan NA, Anwar A, Shah MR, Siddiqui R
SAGE Open Med, 2018;6:2050312118781962.
PMID: 30034805 DOI: 10.1177/2050312118781962
Objectives: To synthesize novel compounds belonging to Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrin classes and test their potential anticancer properties.
Methods: Several compounds were synthesized and their molecular identity was confirmed using nuclear magnetic resonance. Potential anticancer properties were determined using cytopathogenicity assays and growth inhibition assays using cervical cancer cells (HeLa). Cells were incubated with different concentrations of compounds belonging to Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrins and effects were determined. HeLa cells cytopathogenicity was determined by measuring lactate dehydrogenase release using cytotoxicity detection assay. Growth inhibition assays were performed by incubating 50% semi-confluent HeLa cells with Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrin compounds and HeLa cell proliferation was observed. Growth inhibition and host cell death were compared in the presence and absence of drugs.
Results: Cytopathogenicity assays showed that the selected compounds were cytotoxic against HeLa cells, killing up to 90% of cells. Growth inhibition assays exhibited 100% growth inhibition. These effects are likely via oxidative stress, production of reactive oxygen species, changes in cytosolic and intracellular calcium/adenine nucleotide homeostasis, inhibition of ribonucleotide reductase/cyclooxygenase and/or glutathione depletion.
Conclusions: Benzodioxane, Naphthalene diimide, Aminophenol derivatives and Porphyrins exhibited potent anticancer properties. These findings are promising and should pave the way in the rationale development of anticancer drugs. Using different cancer cell lines, future studies will determine their potential as anti-tumour agents as well as their precise molecular mode of action.
Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae
Anwar A, Rajendran K, Siddiqui R, Raza Shah M, Khan NA
ACS Chem Neurosci, 2019 01 16;10(1):658-666.
Central nervous system (CNS) infections caused by free-living amoebae such as Acanthamoeba species and Naegleria fowleri are rare but fatal. A major challenge in the treatment against the infections caused by these amoebae is the discovery of novel compounds that can effectively cross the blood-brain barrier to penetrate the CNS. It is logical to test clinically approved drugs against CNS diseases for their potential antiamoebic effects since they are known for effective blood-brain barrier penetration and affect eukaryotic cell targets. The antiamoebic effects of clinically available drugs for seizures targeting gamma-amino butyric acid (GABA) receptor and ion channels were tested against Acanthamoeba castellanii belonging to the T4 genotype and N. fowleri. Three such drugs, namely, diazepam (Valium), phenobarbitone (Luminal), phenytoin (Dilantin), and their silver nanoparticles (AgNPs) were evaluated against both trophozoites and cysts stage. Drugs alone and drug conjugated silver nanoparticles were tested for amoebicidal, cysticidal, and host-cell cytotoxicity assays. Nanoparticles were synthesized by sodium borohydride reduction of silver nitrate with drugs as capping agents. Drug conjugated nanoconjugates were characterized by ultraviolet-visible (UV-vis) and Fourier transform infrared (FT-IR) spectroscopies and atomic force microscopy (AFM). In vitro moebicidal assay showed potent amoebicidal effects for diazepam, phenobarbitone, and phenytoin-conjugated AgNPs as compared to drugs alone against A. castellanii and N. fowleri. Furthermore, both drugs and drug conjugated AgNPs showed compelling cysticidal effects. Drugs conjugations with silver nanoparticles enhanced their antiacanthamoebic activity. Interestingly, amoeba-mediated host-cell cytotoxicity was also significantly reduced by drugs alone as well as their nanoconjugates. Since, these drugs are being used to target CNS diseases, their evaluation against brain-eating amoebae seems feasible due to advantages such as permeability of the blood-brain barrier, established pharmacokinetics and dynamics, and United States Food and Drug Administration (FDA) approval. Given the limited availability of effective drugs against brain-eating amoebae, the clinically available drugs tested here present potential for further in vivo studies.
Fulltext Gold Nanoparticles Conjugation Enhances Antiacanthamoebic Properties of Nystatin, Fluconazole and Amphotericin B
Anwar A, Siddiqui R, Raza Shah M, Ahmed Khan N
J Microbiol Biotechnol, 2019 Jan 28;29(1):171-177.
PMID: 30415525 DOI: 10.4014/jmb.1805.05028
Parasitic infections have remained a significant burden on human and animal health. In part, this is due to lack of clinically-approved, novel antimicrobials and a lack of interest by the pharmaceutical industry. An alternative approach is to modify existing clinically-approved drugs for efficient delivery formulations to ensure minimum inhibitory concentration is achieved at the target site. Nanotechnology offers the potential to enhance the therapeutic efficacy of drugs through modification of nanoparticles with ligands. Amphotericin B, nystatin, and fluconazole are clinically available drugs in the treatment of amoebal and fungal infections. These drugs were conjugated with gold nanoparticles. To characterize these gold-conjugated drug, atomic force microscopy, ultraviolet-visible spectrophotometry and Fourier transform infrared spectroscopy were performed. These drugs and their gold nanoconjugates were examined for antimicrobial activity against the protist pathogen, Acanthamoeba castellanii of the T4 genotype. Moreover, host cell cytotoxicity assays were accomplished. Cytotoxicity of these drugs and drug-conjugated gold nanoparticles was also determined by lactate dehydrogenase assay. Gold nanoparticles conjugation resulted in enhanced bioactivity of all three drugs with amphotericin B producing the most significant effects against Acanthamoeba castellanii (p < 0.05). In contrast, bare gold nanoparticles did not exhibit antimicrobial potency. Furthermore, amoebae treated with drugs-conjugated gold nanoparticles showed reduced cytotoxicity against HeLa cells. In this report, we demonstrated the use of nanotechnology to modify existing clinically-approved drugs and enhance their efficacy against pathogenic amoebae. Given the lack of development of novel drugs, this is a viable approach in the treatment of neglected diseases.
Brain-Eating Amoebae: Silver Nanoparticle Conjugation Enhanced Efficacy of Anti-Amoebic Drugs against Naegleria fowleri
Rajendran K, Anwar A, Khan NA, Siddiqui R
ACS Chem Neurosci, 2017 12 20;8(12):2626-2630.
The overall aim of this study was to determine whether conjugation with silver nanoparticles enhances effects of available drugs against primary amoebic meningoencephalitis due to Naegleria fowleri. Amphotericin B, Nystatin, and Fluconazole were conjugated with silver nanoparticles, and synthesis was confirmed using UV-visible spectrophotometry. Atomic force microscopy determined their size in range of 20-100 nm. To determine amoebicidal effects, N. fowleri were incubated with drugs-conjugated silver nanoparticles, silver nanoparticles alone, and drugs alone. The findings revealed that silver nanoparticles conjugation significantly enhanced antiamoebic effects of Nystatin and Amphotericin B but not Fluconazole at micromolar concentrations, compared with the drugs alone. For the first time, our findings showed that silver nanoparticle conjugation enhances efficacy of antiamoebic drugs against N. fowleri. Given the rarity of the disease and challenges in developing new drugs, it is hoped that modifying existing drugs to enhance their antiamoebic effects is a useful avenue that holds promise in improving the treatment of brain-eating amoebae infection due to N. fowleri.
Fulltext Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii
Anwar A, Numan A, Siddiqui R, Khalid M, Khan NA
Parasit Vectors, 2019 Jun 03;12(1):280.
PMID: 31159839 DOI: 10.1186/s13071-019-3528-2
BACKGROUND: Species of Acanthamoeba are facultative pathogens which can cause sight threatening Acanthamoeba keratitis and a rare but deadly brain infection, granulomatous amoebic encephalitis. Due to conversion of Acanthamoeba trophozoites to resistant cyst stage, most drugs are found to be ineffective at preventing recurrence of infection. This study was designed to test the antiacanthamoebic effects of different cobalt nanoparticles (CoNPs) against trophozoites and cysts, as well as parasite-mediated host cell cytotoxicity.
METHODS: Three different varieties of CoNPs were synthesized by utilizing hydrothermal and ultrasonication methods and were thoroughly characterized by X-ray diffraction and field emission scanning electron microscopy. Amoebicidal, encystation, excystation, and host cell cytopathogenicity assays were conducted to study the antiacanthamoebic effects of CoNPs.
RESULTS: The results of the antimicrobial evaluation revealed that cobalt phosphate Co3(PO4)2 hexagonal microflakes, and 100 nm large cobalt hydroxide (Co(OH)2) nanoflakes showed potent amoebicidal activity at 100 and 10 µg/ml against Acanthamoeba castellanii as compared to granular cobalt oxide (Co3O4) of size 35-40 nm. Furthermore, encystation and excystation assays also showed consistent inhibition at 100 µg/ml. CoNPs also inhibited amoebae-mediated host cell cytotoxicity as determined by lactate dehydrogenase release without causing significant damage to human cells when treated alone.
CONCLUSIONS: To our knowledge, these findings determined, for the first time, the effects of composition, size and morphology of CoNPs against A. castellanii. Co3(PO4)2 hexagonal microflakes showed the most promising antiamoebic effects as compared to Co(OH)2 nanoflakes and granular Co3O4. The results reported in the present study hold potential for the development of antiamoebic nanomedicine.
Fulltext Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity
Ali SM, Khan NA, Sagathevan K, Anwar A, Siddiqui R
AMB Express, 2019 Jun 28;9(1):95.
The discovery of novel antimicrobials from animal species under pollution is an area untapped. Chinese red-headed centipede is one of the hardiest arthropod species commonly known for its therapeutic value in traditional Chinese medicine. Here we determined the antibacterial activity of haemolymph and tissue extracts of red-headed centipede, Scolopendra subspinipes against a panel of Gram-positive and Gram-negative bacteria. Lysates exhibited potent antibacterial activities against a broad range of bacteria tested. Chemical characterization of biologically active molecules was determined via liquid chromatography mass spectrometric analysis. From crude haemolymph extract, 12 compounds were identified including: (1) L-Homotyrosine, (2) 8-Acetoxy-4-acoren-3-one, (3) N-Undecylbenzenesulfonic acid, (4) 2-Dodecylbenzenesulfonic acid, (5) 3H-1,2-Dithiole-3-thione, (6) Acetylenedicarboxylate, (7) Albuterol, (8) Tetradecylamine, (9) Curcumenol, (10) 3-Butylidene-7-hydroxyphthalide, (11) Oleoyl Ethanolamide and (12) Docosanedioic acid. Antimicrobial activities of the identified compounds were reported against Gram-positive and Gram-negative bacteria, fungi, viruses and parasites, that possibly explain centipede's survival in harsh and polluted environments. Further research in characterization, molecular mechanism of action and in vivo testing of active molecules is needed for the development of novel antibacterials.
Fulltext Antidiabetic Drugs and Their Nanoconjugates Repurposed as Novel Antimicrobial Agents against Acanthamoeba castellanii
Anwar A, Siddiqui R, Raza Shah M, Khan NA
J Microbiol Biotechnol, 2019 May 28;29(5):713-720.
PMID: 31030451 DOI: 10.4014/jmb/1903.03009
Acanthamoeba castellanii belonging to the T4 genotype may cause a fatal brain infection known as granulomatous amoebic encephalitis, and the vision-threatening eye infection Acanthamoeba keratitis. The aim of this study was to evaluate the antiamoebic effects of three clinically available antidiabetic drugs, Glimepiride, Vildagliptin and Repaglinide, against A. castellanii belonging to the T4 genotype. Furthermore, we attempted to conjugate these drugs with silver nanoparticles (AgNPs) to enhance their antiamoebic effects. Amoebicidal, encystation, excystation, and host cell cytotoxicity assays were performed to unravel any antiacanthamoebic effects. Vildagliptin conjugated silver nanoparticles (Vgt-AgNPs) characterized by spectroscopic techniques and atomic force microscopy were synthesized. All three drugs showed antiamoebic effects against A. castellanii and significantly blocked the encystation. These drugs also showed significant cysticidal effects and reduced host cell cytotoxicity caused by A. castellanii. Moreover, Vildagliptin-coated silver nanoparticles were successfully synthesized and are shown to enhance its antiacanthamoebic potency at significantly reduced concentration. The repurposed application of the tested antidiabetic drugs and their nanoparticles against free-living amoeba such as Acanthamoeba castellanii described here is a novel outcome that holds tremendous potential for future applications against devastating infection.
Fulltext Early Experience of Reverse Total Shoulder Arthroplasty in a Public Hospital in Malaysia
Sam CX, Anwar AZ, Ahmad AR, Solayar GN
Malays Orthop J, 2021 Mar;15(1):119-123.
PMID: 33880158 DOI: 10.5704/MOJ.2103.018
Introduction: Reverse total shoulder arthroplasty provides a surgical alternative to standard total shoulder arthroplasty for the treatment of cuff tear arthropathy, arthritis and fracture sequelae. This study aimed to assess the short-term outcomes following reverse total shoulder arthroplasty for patients in a large public hospital in Malaysia.
Materials and Methods: We identified and performed five primary reverse total shoulder arthroplasties between 1 May 2019 and 1 June 2020. All patients were contactable and available for analysis. Assessment of functional outcomes was performed using the Constant-Murley score, the patient satisfaction score (PSS), and imaging studies. The mean follow-up from operation to the time of reporting was 9.6 months (range, 3 to 14 months).
Results: The median age for our patients was 58 years (±11.91). The most common indication for surgery was post-traumatic arthritis, followed by rotator cuff arthropathy and osteoarthritis. The mean Constant score improved from 9.0 pre-operatively to 52.3 post-operatively at a mean of 9.6 months. The majority of the patients were satisfied with the surgery as the post-operative range of motion, especially anterior elevation and abduction, improved in four of our patients and there were no short-term complications, for example, of infection or revisions, reported at the last follow-up.
Conclusion: This study has shown that reverse total shoulder arthroplasty can yield good short-term outcomes for the treatment of complex shoulder problems in addition to cuff tear arthropathy. It should be considered a treatment for rotator cuff tears, severe arthritis and ≥ 3 parts proximal humeral fractures.
Brain-eating Amoebae Infection: Challenges and Opportunities in Chemotherapy
Mungroo MR, Anwar A, Khan NA, Siddiqui R
Mini Rev Med Chem, 2019;19(12):980-987.
Pathogenic free-living amoeba are known to cause a devastating infection of the central nervous system and are often referred to as "brain-eating amoebae". The mortality rate of more than 90% and free-living nature of these amoebae is a cause for concern. It is distressing that the mortality rate has remained the same over the past few decades, highlighting the lack of interest by the pharmaceutical industry. With the threat of global warming and increased outdoor activities of public, there is a need for renewed interest in identifying potential anti-amoebic compounds for successful prognosis. Here, we discuss the available chemotherapeutic options and opportunities for potential strategies in the treatment and diagnosis of these life-threatening infections.
amebicides
acanthamoeba castellanii
naegleria fowleri
acanthamoeba castellanii/drug effects
amebicides/pharmacology
amebicides/chemistry
naegleria fowleri/drug effects


Teak is expensive! But I now have a nice piece of 2'x8″ wide and 1″ thick teak lumber, ready to be milled down a bit to fit over two rather unsightly holes left in the deck after removing the electric winch that came with the boat, sans motor. Unfortunately they were cut through a rather thick teak plank custom mounted on the bow, and my tools and carpentry skill aren't up to making an exact fit teak plug to fill the holes, so after three layers of plywood and epoxy, the holes are filled. You can't varnish epoxy and as delightful as my glass work is, I don't want it on full time display. So the quick, easy and $33.86 is a nice piece of teak to cover the holes with, and then I can mount my $100 manual windlass, complete with 4 coats of white paint. After that I can get all the exercise I want pulling up the anchor. I'm pretty excited, this is my 4th sailboat, and this will be my first working windlass.


The basic motive of BFM at L. S. Raheja College of Arts and Commerce is to inculcate in the students the drive to acquire knowledge about Financial Services and help the students to have a great future ahead in Financial Markets.
Orientation Program was held on 2ndJuly 2014 to orient the First Year BFM students.
Library Orientation Program was held on 11th July 2014 to inculcate the practice of usage of Library.
The college Annual Day was celebrated on 24th December 2014 at St. Andrew's Auditorium, Bandra.
Inter - Collegiate Academic Festival: FINACCIN '2015 was organized jointly by BFM & BAF & BBI students of our college on 11th &12th January 2015.
Campus Recruitment by J.P. Morgan was organized on 23rd January, 2015 for TYBFM students and Ms. Nicolatte Coutinho has been selected and provided with an offer letter.
Convocation Day for T.Y.B.F.M. students who successfully passed April 2014 Examination was organized on 2nd February 2015.
Industrial visit to Silvassa was organized for the students of FY, SY and TY on 26th February 2015.
Students from B.F.M. have enrolled for Department of Life-long Learning & Extension Work: 2014-2015 by University of Mumbai to gain more practical knowledge about extension activities.
Experts from Ambition Learning Solution have undertaken an interactive sessions on 'CFP'.
Seminar on 'Financial Markets' by Mr. Hemant Kale was organized on 12th January 2015.
Seminar on 'Accounting' by Mr. Bihari Lal was organized on 12thJanuary 2015.
Seminar on 'Banking' by Mr. Bihari Lal was organized on13th January 2015.
Seminar on 'Insurance' by experts were organized on 13th January 2015.
Apart from these, the faculty members and students have been actively participating in several seminars, workshops and conferences organized by different colleges as well as by the Department of Life Long Learning and Extension.
As per the university guidelines a student is required to maintain minimum 75% attendance in each subject in every semester.
The Department display attendance records to students twice a semester i.e. one in mid-July and other in mid-August and for second half of the Academic year – one in mid-January and other in mid-February. Students whose names appear in the 1st attendance list as Defaulters are given a verbal warning and an undertaking is collected by the co-ordinator and if the same appears in the second list, Parents are called for a meeting and the attendance defaulter student is given an extra project work related to the subject in which he/she has defaulted in attendance.
Fresher party for F.Y.B.F.M. students in the month of July 2014.
Students presented a Comedy Drama, Dance Melody & Fashion Show in the Annual Day celebrations.
Participation in Dance & Fashion Show at Mirage'2014 organized by Nagindas Khandwala College.
Participation in management events at Mood Fiesta'2015 organized by Lala Lajpatrai College.
Students participated in sports events like chess and football at inter-collegiate level.
Students participated in several events like glass painting, essay competition, dance events at B. L. Amlani College Festival, Elysium. The students also won a few competitions in the same fest.
FinAccIn as the name suggests is an academic event which envelopes the major fields of commerce - Finance, Accounts, Banking and Insurance. It is an intercollegiate event organized by the students of B.A.F., B.B.I. and B.F.M. departments of L.S. Raheja College of Arts and Commerce. The motto of the event is "Aim High, Think Big, Work Hard" which signifies that the students must aim for high targets in life, think as big as possible and in order to fulfil this, we must work hard.
This year, Finaccin was organized on12th and 13th January 2015. The prime focus of the event was to explore the insights and talents of the students through various activities. Finaccin amalgamated the themes of fun and learning and provided a pedestal to the students to understand the corporate world practically. It not only provided a direct access to knowledge but also gave the students a chance to showcase their aptitude through presentations.
Participants from colleges across Mumbai came to attend this event and helped in making it a grand success. The overall feedback of the students was positive and there was ample amount of participation by students. The enthusiasm amongst the students was palpable. The festival ended on a positive note with students aspiring for more in the next year.


tl;dr; If you want the fastest possible schedule, pay continuous attention to technical excellence.
An important corollary to that principle is that technical mediocrity and poor design hurt agility. Brushing off attention to technical excellence because Agile breaks an Agile principle.
Technical excellence is arguably one of the more important Agile principles. One of the Agile Manifesto signatories is Robert C. Martin, author of Clean Code and other popular books on Agile software development. When an Agile manifesto signatory writes an entire book on clean code, the implication is that technical excellence is important.
Overly optimistic schedules which abbreviate "critical upstream development activities... such as design."
Shortchanged upstream activities which usually lead to doing "the same work downstream at anywhere from 10 to 100 times the cost."
Inadequate design with a "design emphasis is on expediency rather than quality."
Shortchanged quality assurance such as "eliminating design and code reviews..." or giving "design reviews and code reviews... short shift."
Code-like-hell programming which is a "fast, loose, all-as-you-go coding" approach which is sometimes presented as "entrepreneurial."
These classic mistakes make us stiff and slow whereas continuous attention to technical excellence makes us agile and fast. Our development velocity increases by doing the opposite of those classic mistakes.
Attending to technical excellence is hard, but it is doable, it is faster, and it is worth it. In addition to increasing delivery velocity, it has positive side effects such as increased team morale.
https://sqa.stackexchange.com/questions/25897/will-implementing-agile-generally-improve-code-quality Free, peer-reviewed reading on Agile and code quality in the Software Quality Assurance site in StackExchange.
Martin, R. C., Coplien, J. O., Wampler, K., Grenning, J. W., Schuchert, B. L., Langr, J., Ottinger, T. R., ... Feathers, M. C. (2016). Clean code: A handbook of agile software craftsmanship.
McConnell, S. (2014). Rapid development: Taming wild software schedules. Redmond (Washington: Microsoft Press.
String index signatures let us restrict the types that an object can contain.
In chapter 28 of Rapid Development, McConnel (2014) calls the "throwaway prototype" a software development best practice; he also warns that keeping the throwaway prototype is a classic software development mistake.


In the present period of time, there are a lot involving dwelling variations varieties that have leapt upwards, and this Accent Wallpaper Bedroom graphic stock could show them to you. Around Accent Wallpaper Bedroom photo gallery one can find several property designs drive of which to be a movement now. Many available beautifully inside Accent Wallpaper Bedroom photo gallery. You may look into Accent Wallpaper Bedroom snapshot gallery subsequently you can find lots of appealing things you will be able to carry with in that respect there.
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text:
Q: Discord.js - How do I convert user ID to Member I am wondering how to convert an ID to a Member. The ID I want to convert is in a .JSON file. I have this script:
if(message.content == "!fl leaderboard") {
        embed = new Discord.MessageEmbed()
        const c = Object.entries(db).sort((a, b)=> b[1].level - a[1].level)
        for(const [key, value] of c) {
            embed.addField(db[message.author.id].tag, `Level: ${value.level} | XP: ${value.xp}`)
        }
        message.channel.send(embed)
    }

And this is what it posts:
The script of the level system is: https://hastebin.com/epucihenin.js

A: const User = client.users.cache.get("userid");
if (!User) return console.error("Couldn't find the user"); // Note that the user must be in a Guild with your bot for this to work.

console.log(`I found the user ${User.username}.`);

A: You can use guild.member() to get a member object from a user object, and you can use client.users.fetch() to get a user object from an ID.
.member()
.fetch()

redpajama_set_name: RedPajamaStackExchange


Experiments showinga swift and reversible swap ofcolor s eem likemagic and are regularly interesting. the method concerned, photochromism, has a number of actual and plenty of power purposes. Photochromic glasses thatdarken int he s unlight (protecting eyes from over the top gentle depth) and bleach ind im lighta re at the present time a component ofe v eryday existence.
Aminothiazoles and their Derivatives 22 n -+ T * transitions have never been reported; they may be hidden by the absorption band related to the 7~ -+ T * transition. 2-p-R-Aryl-4-amino-5-benzoylthiazolesabsorb in the region of 389 nm ( E = 12,000), and the influence of R substituents on the band position was determined: R = MeO, A = 395 nm; R = NMe,, A = 429 nm (49,50). Table VI-2 contains representative ultraviolet data for 2-aminothiazoles and 2-iminothiazolines. r symmetry mainly located on C-5 and N-3: the "weights" of the atomic orbital in this MO TABLE VI-2.
Y (205) as summarized in Scheme 40. The important point is that in corxentrated sulfuric acid even dealkylation may take place: 56 457. Me. MexANapr MkJ\NwR ' Me, Et-C McElCHOH 58 H' 59 Scheme 40 All the examples of reactivity in acidic medium (Scheme 40) involve a reagent with a sp3C hybridized electrophilic center, but the actual reactive species generated bears a sp2C electrophilic center. 2). Thus the reactivity of 2-aminothiazole derivatives toward reactants bearing a sp3C hybridized electrophilic center follows the general pattern: 1.
Me XJ. Scheme 70 102 Chlorothioformic phenyl ester (103)reacts under mild conditions with 2-arninothiazole to give 104 (Scheme 71) (266). cl + PhOCSCl 2-% G N H C O P h NHZ II 103 Scheme 71 104 S 52 Aminothiazoles and their Derivatives b. REACTIONS WITH ACIDS AND THEIR ANHYDRIDES Acetic anhydride and sodium acetate when heated with 2aminothiazole for 2 hr give 2-acetamidothiazole 105 (Scheme 72) (243). Scheme 72 105 Quantitative studies of solid-state organic reactions were performed by Glazman (267, 268).


text:
Trailer: 27: Gone Too Soon
Brian Jones, Jimi Hendrix, Janis Joplin and Jim Morrison all died at the age of 27 between 1969 and 1971. At the time, the coincidence gave rise to some comment, but it was not until the death of Kurt Cobain, about two and a half decades later, that the idea of a "27 Club" began to catch on in public perception, reignited with the death of Amy Winehouse in 2011. Through interviews with people who knew them, such as music stars, critics, medical experts and unseen footage, the lives, music, and artistry of those who died at 27 are investigated with a bid to find answers.
Actor: Steve Blame, Gary Numan
Director: Simon Napier-Bell
Tagged: #27: Gone Too Soon
Killing Daddy
Killing Daddy HD
When Cassie's father finds himself vulnerable and bedridden, she believes she has the perfect revenge for her mother's death.
Genre: Crime, Mystery, Thriller
Director: Killing Daddy
Actor: Elizabeth Gillies, Cynthia Stevenson, William R. Moses, Sebastian Pigott
War on Everyone HD
Two corrupt cops set out to blackmail and frame every criminal unfortunate enough to cross their path. Events, however, are complicated by the arrival of some..
Director: John Michael McDonagh
Actor: Michael Peña, Alexander Skarsgård, Theo James, Tessa Thompson, Caleb Landry Jones, Stephanie Sigman, David Wilmot, Malcolm Barrett, Paul Reiser, Zion Rain Leyba
Teddy Boy HD
A grieving affluent couple draws a visiting tennis player and thief into a savage charade where betrayal becomes its own redemption.
Genre: Action, Drama, Thriller
Director: Sean Jourdan
Actor: Joey Bicicchi, Deric Gallagher, Huckle Houle, Thomas Jaeger, Robert Johnson, Mike Lamp, Woody Oliver, Danielle Prall, Jamieson Reinhard
Hunchback of the Morgue
Hunchback of the Morgue HD
Paul Naschy plays a hunchback with below average intelligence who works at the morgue. He is in love with a sickly girl who happens to be the only person who ..
Director: Javier Aguirre
Actor: Paul Naschy, Rosanna Yanni, Víctor Alcázar, María Elena Arpón, Manuel de Blas, Antonio Pica, Kino Pueyo, Ángel Menéndez, Sofía Casares, Antonio Mayans
Sophie and the Rising Sun HD
Autumn of 1941 in Salty Creek, a fishing village in South Carolina, two interracial lovers are swept up in the tides of history.
Director: Maggie Greenwald
Actor: Julianne Nicholson, Takashi Yamaguchi, Margo Martindale, Diane Ladd, Lorraine Toussaint, Karen Wheeling Reynolds, Mickey Dodge, Don Henderson Baker, Joel Murray, David Dickson Reynolds
Time Apart (Unofficial Hindi Dubbed)
Time Apart (Unofficial Hindi Dubbed) HD
Time Apart explores a long distance relationship with a sci fi twist when Seb starts mysteriously vanishing for years at a time, girlfriend Nina struggles to ..
Genre: Romance, Sci-Fi, Drama, Hindi-Dubbed
Director: Ric Forster
Actor: Siobhan Connors, Nathan Luke, Bastian Navarria, Eliza Charley, S.C. Wilson, William Prescott
JFK HD
New Orleans District Attorney Jim Garrison discovers there's more to the Kennedy assassination than the official story.
Genre: Drama, History, Thriller
Director: Oliver Stone
Actor: Kevin Costner, Tommy Lee Jones, Gary Oldman, Kevin Bacon, Michael Rooker, Jack Lemmon, Laurie Metcalf, Sissy Spacek, Joe Pesci, John Candy
Spooks: The Greater Good HD
When a terrorist escapes custody during a routine handover, Will Holloway must team with disgraced MI5 Intelligence Chief Harry Pearce to track him down befor..
Actor: Peter Firth, Kit Harington, Jennifer Ehle, Lara Pulver, Elyes Gabel, Tuppence Middleton, Tim McInnerny, Eleanor Matsuura, David Harewood, Hugh Simon
Horrible Bosses 2 HD
Dale, Kurt and Nick decide to start their own business but things don't go as planned because of a slick investor, prompting the trio to pull off a harebraine..
Director: Sean Anders
Actor: Jason Bateman, Jason Sudeikis, Charlie Day, Jennifer Aniston, Kevin Spacey, Jamie Foxx, Chris Pine, Christoph Waltz, Jonathan Banks, Lindsay Sloane
Seeking a Friend for the End of the World HD
As an asteroid nears Earth, a man finds himself alone after his wife leaves in a panic. He decides to take a road trip to reunite with his high school sweethe..
Genre: Adventure, Comedy, Drama
Director: Lorene Scafaria
Actor: Steve Carell, Keira Knightley, Connie Britton, Adam Brody, Rob Corddry, Derek Luke, Melanie Lynskey, William Petersen, Gillian Jacobs, T.J. Miller
Theatre of the Dead
Theatre of the Dead SD
A dance troupe trapped in their theatre by the Zombie Apocalypse discover that the threat doesnt just lie beyond the chained doors, and that there are indeed ..
Director: Patrick J. Gallagher
Actor: Emma Gleeson, Rob Baird, Ché Baker
The Flu HD
A case of the flu quickly morphs into a pandemic. As the death toll mounts and the living panic, the government plans extreme measures to contain it.
Genre: Action, Drama, Sci-Fi
Director: Kim Sung-soo
Actor: Jang Hyuk, Soo Ae, Park Min-Ha, Yoo Hae-jin, Ma Dong-seok, Lee Hee-joon, Lee Sang-yeob, Cha In-pyo, Kim Ki-hyeon, Park Hyo-ju


My first progress snap of the first diamond, minus 4 rows. I wasn't sure I was going to enjoy this pattern. However, now that I've completed the first diamond, my brain has finally absorbed the symbols and the pattern itself has begun to insert itself into my fingers. It is so strange that after all of these years, this phenomenon eluded me until I began to knit lace.
Yum! I'll be interested to hear how you enjoy working with the silk.


text:
Keep A Child Alive Announces 2008 Black Ball Details
Keep A Child Alive's fifth annual Black Ball Gala, hosted by Ambassadors Alicia Keys and Iman, will take place at The Hammerstein Ballroom in New York City on Thursday, November 13, and will honor the global AIDS work of three remarkable humanitarians.
The event – chaired by Jessica Alba – will begin with a cocktail party followed by a seated dinner with extraordinary live performances by Alicia Keys, Justin Timberlake, Joni Mitchell, Jack White, Jennifer Hudson and more very special guests to be announced.
Keep A Child Alive's humanitarian honorees are an incredible group of people who have used their will, fame, and courage to change the lives devastated by this pandemic. Guest presenters pay tribute to the work of the honorees through powerful moving footage.
This year the organization will honor Simon Fuller, CEO & founder of 19 Entertainment Limited for spearheading the Idol Gives Back phenomenon and mobilizing Americans to take action; Queen Latifah, for being one of the incredible pioneers in the fight against AIDS; and Jackie Branfield, founder of Operation Bobbi Bear for being a true hero in the lives of children in South Africa. Previous honorees include Bono, rock star and campaigner for Africa; Dr. Stephen Lewis of The Stephen Lewis Foundation and author of Race Against Time; Richard Beckman of Condé Nast Media Group; Nick Reding of Sponsored Arts for Education; and Dr. Shaffiq Essajee Pediatric Advisor on AIDS for the Clinton Foundation.
More info about the event can be found at www.keepachildalive.org.
Source: Keep A Child Alive
Celebrities:
Simon Fuller
Keep A Child Alive
Stephen Lewis Foundation
Causes:
Family/Parent Support
Adoption, Fostering, Orphans
Economic/Business Support
U2's The Edge and Bob Ezrin Launch ohyay Gallery to Celebrate Guitar Icons: A Musical Instrument Auction Dec 2, 2021
Ohyay, a virtual event platform, has partnered with the charity Music Rising to launch a first-of-its-kind guitar viewing gallery in anticipation of "Guitar Icons: A Musical Instrument Auction to Benefit Music Rising" on December 11th. More →
Chopra Global And Alicia Keys Release New 21-Day Meditation Experience May 19, 2021
Alicia Keys And The Class Unite For A Powerful Collaboration To Promote Mental Wellbeing May 5, 2021
Connie Britton Talks About Pandemica Apr 13, 2021
Lifetime of Leadership - Girl Scouts
On Top of the World | Shell #makethefuture
Take our "What the HF" Quiz - Message from Queen Latifah
Buy Vision Give Sight
Scleroderma Research Foundation Announces $1.5M Matching Gift in Honor of Bob Saget Jan 17, 2022
The Scleroderma Research Foundation (SRF)—the country's first and leading nonprofit investor in medical research into scleroderma—announced a $1.5 million dollar matching gift, in the form of a grant to match every donation made in honor of the late Bob Saget, SRF Board member, comedian, actor, writer, director, producer, and philanthropist. More →
Alesha Dixon Calls For the Queen's Guard's Caps to Be Made With Faux Bear Fur Jan 14, 2022
Ali Stroker to be Honored at the ADAPT Leadership Awards Celebrating the 75th Anniversary of ADAPT Community Network Jan 13, 2022
Stephen and Ayesha Curry's Eat. Learn. Play. Gives Back $5 Million Into Oakland Community Jan 12, 2022


text:
PIRATES SEIZE FRENCH YACHT LE PONANT
Associated Press report 4 April 2008
PARIS, France (AP) -- Pirates seized control of a French cruise ship Friday off the coast of Somalia, France's Foreign Ministry said.
A ministry official said details about the attack were scarce, and it was not clear how many crew members were on board the ship or if there were any passengers.
The ship is in the high seas in the Gulf of Aden, off the coast of Somalia in the Indian Ocean.
The official declined to identify the vessel or its owner.
The ministry has set up a crisis center to deal with the situation, said the official, who asked not to be named because he was not authorized to discuss the matter publicly.
MMNETSEA has information that the "Ship" is the M/Y "Le Ponant" - normally carrying a crew of 30.
The above report has the Ship in 2 places at once 'The ship is in the high seas in the Gulf of Aden, off the coast of Somalia in the Indian Ocean.'
BBC and AP both now confirm that vessel is the "Le Ponant" - returning without passengers from the Seychelles to the Med. It won't be difficult to find it, the problem will be making sure the crew are not at risk when the French, German and American Cavalry arrive on the horizon.
Originally Posted by MMNETSEA
The Ponant now anchored off Eil (Eyl or Bedia) at 7º 57.281' N x 49º 51.49E
Eil Village
Wiki info on Eil : Link
Home Port: Who cares really...
Vessel Name: T
Should be interesting to see how this plays out.
http://allafrica.com/stories/200804071893.html
http://www.ponant.com/index.php?nav=IE&lang=en
"Pirates holding French yacht shoot at militia"
Full story HERE (Click on the photo for more pics)
Anything new on this situation?
Originally Posted by Trim50
A couple of hours ago - Lloyds reported :-
"There was no fresh news regarding the Le Ponant and its more than 30 crew members yesterday. The vessel was believed to be still at anchor under pirate control off the coastal town of Garacad, south of the port of Eyl.
French Defence Minister Hervé Morin said that the government was still in contact with the pirates but wanted to give no information which might endanger the lives of the vessel's crew.
Meanwhile, the head of British shipping union Nautilus UK has written to foreign secretary David Miliband, asking him to outline the government's position on the payment of ransom for seafarers taken captive by pirates.
He also raises the issue of the support available to shipping from friendly naval forces in piracy hotspots, and backs International Maritime Organization calls for governments to be more proactive in providing protection.
The letter from general secretary Brian Orrell comes after a Nautilus UK member was involved in the hijack of St Vincent & Grenadines-flagged tug Svitzer Korsakov, with the stand-off only resolved after the owners reportedly paid £350,000 ($689, 476) to the criminals to secure the release of the vessel and crew.
Mr Orrell speaks of a "disturbing deterioration in the nature of the incidents and the levels of violence and intimidation being used against seafarers".
He goes on: "In this context, I wish to request that the Foreign and Commonwealth Office reconsiders its policies on piracy, and notably in the areas off Somalia.
"In particular, it is important to have assurances about the levels of assistance and protection for British seafarers – irrespective of the flag of their ship – operating in high-risk waters."
COMMENT :-
In view of the continuous warnings to keep at least 200 nm off the East Coast of Somalia - one wonders why the Master of the Le Ponant decided to stay close to the coast on his way north from the Seychelles. Another question is how the Pirates managed to take this ship - which is said to be capable of 26 knots.
Just Reported :- the French Government have dispatched the GIGN to the area when Le Ponant is anchored.
click on GIGN
Like I said before, this will be interesting to see played out. It could invoke some changes...hopefully!
France negotiates with pirates who hijacked French luxury yacht Le Ponant off coast of Somalia
In France, the families of the 22 French hostages meet in Paris with Nicolas Sarkozy as France talks to Le Ponant's attackers.
22 French nationals were taken hostage aboard the French luxury yacht Le Ponantby 10-12 armed pirates who boarded and hijacked the boat last Friday in the Gulf of Aden as it was on its way from the Seychelles to the Mediterranean.
The families of the French crew members met in Paris yesterday with President of France Nicolas Sarkozy. Foreign Affairs Minister of France Bernard Kouchner says the government of France is in communication with the pirates and that everyone hopes the matter can be resolved "without any bloodshed," adding the the process could take some time. But while the French negotiate, they are also putting French special forces in place, leaving options open for a more forceful operation. The boat is being tracked from the air by surveillance aircraft and from the water by battleships in the area. In addition to the 22 French nationals, there are also some 10 more crew or Ukrainian and South Korean descent. No passengers for France or elsewhere were aboard at the time of the incident.
The 32-cabin Le Ponantis equipped with lounges, bar and a restaurant, is one of three operated by the French cruise operator CMA-CGM, based in Marseille, which describes itself as France's leading cruise provider. With a capacity for 64 passengers, it offers cruises in the Gulf region, including between Egypt and Aqaba in Jordan, and off the coast of Oman. Le Ponant was set to pick up passangers in Malta later this month.
The part of the Indian Ocean where the Ponantwas attacked has become a known nest of pirates and hijackers, who regularly seize civilian vessels and then demand ransom for passengers and crew. In 2007 alone, 25 incidents took place in the waters off Somalia. Protection convoys are ordered for ships bringing aid to Somalia as these are tempting targets for the pirates. The International Maritime Bureau has reported that global pirate attacks rose 10 percent in 2007, marking the first increase in three years. The Bureau has advised civilian vessels to steer clear of the area. The hijacking of the Ponant was the second attack in the area in two days.
The French warship Le Commandant Rouen has been diverted from NATO's Afghanistan operation to join the Yemeni coast guard in the hunt for and rescue of the captured French yacht.
Opinion is mixed on France's approach to the crisis, with some saying that any appearance of giving in to the pirates' demands will only encourage similar incidents.
Pirates release French yacht crew
The crew of a luxury French yacht held by pirates near Somalia have been freed "without incident", French President Nicolas Sarkozy has said.
He thanked the French military for their role in freeing the 30 hostages on board The Ponant which was taken in the Gulf of Aden last Friday.
The 850-tonne, three-masted yacht was sailing back to the Mediterranean from the Seychelles when it was seized.
Somali coastal waters are known to be among the most hazardous in the world.
More than 25 ships were seized by pirates there in 2007.
"The president expresses his deep gratitude to the French armed forces and all the state services which enabled a rapid and peaceful solution to this hostage-taking," Mr Sarkozy's statement said, without giving further details.
France has troops in nearby Djibouti and also participates in a multinational naval force that patrols this part of the Indian Ocean.
So do you think a ransom was paid?
.quote name='Trim50' date='Apr 11 2008, 09:24 AM' post='19903']
I have not seen any info in the papers about the incident. I would assume the money was paid. If there had been military intervention, you would have heard about it somewhere in the media. The French have paid before. What is the status of the ship? If it is still in the pirates' hands, it is probably in need of a refit. Patching a few bullet holes would not be that much more work. Turning the pirates into fish bait may help the fish population.
Yes, the ship's owners paid a ransom, and the crew was released by the pirates. Once the the crew had been brought ashore safely, French attack helicopters tracked the pirates, believed to be fishermen, to the village of Jariban and moved in when they saw some of them attempting to flee the scene.
A sniper disabled the engine of the get-away car, while another helicopter dropped off three French commandos who captured six of the 12 pirates. The pirates "gave themselves up without too much difficulty", the French general said, adding that those captured would be handed over to French justice officials.
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French Ship Taken By Pirates MMNETSEA Regional Discussion Topics 0 09-14-2008 10:07 AM


with both new buildings being completed simultaneously in 2017 or 2018 ..."
MoMA expects to have the building demolished by the end of this year.
When a new home for the American Folk Art Museum opened on West 53d Street in Manhattan in 2001 it was hailed as a harbinger of hope for the city after the Sept. 11 attacks and praised for its bold architecture.
Now, a mere 12 years later, the building is going to be demolished.
In its place the adjacent Museum of Modern Art, which bought the building in 2011, will put up an expansion, which will connect to a new tower with floors for the Modern on the other side of the former museum. And the folk museum building, designed by Tod Williams and Billie Tsien, will take a dubious place in history as having had one of the shortest lives of an architecturally ambitious project in Manhattan.
MoMA officials said the building's design did not fit their plans because the opaque facade is not in keeping with the glass aesthetic of the rest of the museum. The former folk museum is also set back farther than MoMA's other properties, and the floors would not line up.
"It's not a comment on the quality of the building or Tod and Billie's architecture," Glenn D. Lowry, MoMA's director said.
Mr. Lowry personally went to the architects' offices to inform them of the museum's decision, a gesture that Ms. Tsien said she appreciated.
acclaimed when it opened 12 years ago, is going to be demolished.
The folk art museum, which had once envisioned the building as a stimulus for its growth, ended up selling the property, at 45 West 53d Street, to pay off the $32 million it had borrowed to finance an expansion. It now operates at a smaller site on Lincoln Square, at West 66th Street.
Mr. Lowry said the expansion would complete the MoMA campus, which will ultimately consist of five buildings, four of them on West 53rd Street between Fifth Avenue and the Avenue of the Americas.
Still to be built is an 82-story tower just west of the folk museum that is being developed by Hines, a Houston company, and was designed by the French architect Jean Nouvel. It will include apartments as well as exhibition space for the museum.
The cost for the project has not been announced, he said, and fund-raising has yet to begin.
MoMA's 2004 renovation, designed by the Japanese architect Yoshio Taniguchi, increased the museum's gallery space to 125,000 square feet, from 85,000 (and the overall size to 630,000 square feet, from 378,000). But the museum still needs more room for exhibitions.
Ms. Tsien said she and Mr. Williams, her husband, wished the Modern had found a way to reuse what they designed and to realize its value.
The Modern will interview architects to design the new addition, Mr. Lowry said, and hopes to select one by the end of this year. It expects to have the building demolished by then.
Construction of the Nouvel project is expected to start in 2014, with both new buildings being completed simultaneously in 2017 or 2018, Mr. Lowry said.
The museum has been aggressive about expansion. In 1996 it bought the Dorset Hotel, a 1920s building on West 54th Street, and two adjacent brownstones, using much of the sites for its extensive renovation in 2004.
In 2007 the museum sold its last vacant parcel of land for $125 million to Hines, which decided to develop the Nouvel building and include space for the museum.
But residents protested the height and the Department of City Planning demanded that Mr. Nouvel cut 200 feet from the top. He did so, and in 2009 the City Council approved plans for a tower that is to rise 1,050 feet.
Yes it's a nice little building but as I've said before, the traffic layout of the floor plan is awkward.
It would be nice if the building could be rebuilt in a less vulnerable location. As a fairly new structure, the plans are surely still available.
It sounds like the Verre, in fact, will be built. This is good news. Hopefully, something nice rises at 225 W 57th too. Both of them could draw attention from CIM's stick.
Part of the reason I don't think 432 Park will be so bad is that it'll have taller company in only a few years. The original 1,250' Verre would've been even better, but 225W57th will dwarf 432 Park by at least 150 feet, probably 200-250... By the 2020s, hopefully it'll be a giant amongst many others, so it won't be THAT bad.
I hope that you're right. Every time I've walked by, the concrete looked lousy.
but 225W57th will dwarf 432 Park by at least 150 feet, probably 200-250... By the 2020s, hopefully it'll be a giant amongst many others, so it won't be THAT bad.
225 W57th will be about 3300 feet away from 432 Park. They won't be in the same dialog.
You don't think so? The distance may be 3K+ feet but that isn't huge... certainly in skyline shots, they will be in the same 'dialogue'.
& LL: agreed re 432 Park's concrete. Last update from YIMBY shows how the grey streaks aren't fading as hoped, despite the first exterior forms being poured 2+ months ago... I would think the curing process is complete, so the concrete will be permanently 'streaked'? If they fail to laminate/cover up the concrete, I think this could be quite the eyesore.
The dialog as such that one won't dominate the other. The distance is a little more than that between ESB and Chrysler. You can't say that the ESB dominates Chrysler the way that 1 WTC dominates Woolworth.
Looking at it from a different, er, perspective: In all Manhattan views east of 5th Ave, all of Brooklyn and Queens, 432 will appear taller.
I agree. I walked by on the 56th St side about two weeks ago, and the concrete looked horrible. Mr. Kurtz would have been terrified.
This is tough to judge based on the colors. While concrete typically reaches 90% of it's maximum strength in 4 weeks, it can continue curing for years. It's quite possible the building will continue to brighten for a very long time, similar to the patina that builds on new copper roofs/buildings in the city.
That said, it might not, and they may need to consider a sizable Sherwin Williams order.
The cost of this building nearly killed the Museum of American Folk Art.
But somebody should preserve + re-use the great facade panels.


I'm so excited that I can finally spill the beans on this Sally Dress I sewed up last month as a pattern test for Shannon over at luvinthemommyhood! Don't you just love this vintage look with a few mod twists!?!
I opted for an all over print, but I think a color blocked look or a mix of prints would be fun as well. The fabrics you see here are Chelsea Anderson's Miss Mod. I'm also eager to try out the bodice in a knit.
Let's take a closer look at the bodice. First, note what you don't see. No buttons and no zippers. Yea! Next, notice the nice square neckline and unique shoulder straps. The bodice is fully lined, and Shannon gives you great illustrations for a method that gets all those edges nice and crisp.
And, those jumbo pockets ROCK! I love that you can line the pockets with a coordinating fabric for a little surprise pop of color.
The pockets extend all the way to the hem, so there is plenty of room for favorite treasures!
I can attest to the fact that The Sally Dress pattern has been tested and retested as needed to guarantee a great fit and clear instructions. Avery has picked this dress to wear over and over, so it passes the little girl test as well! The pattern comes with three different sleeve variations as well. Perfect for taking it into the fall!
You can purchase The Sally Dress Pattern here.
Super cute dress, love the fabric!
I definitely wanted to highlight those cute birds on the bodice and pockets. Thanks for noticing!
Thanks again Courtney! She looks gorgeous in it!
I really love this pattern! I can't wait to make one for my almost two year old. She just needs to grow a tab bit.
That shoulder detail is so unique.
You sure have been having fun lately playing around with fabrics and sewing patterns ~ at least it looks like you've been having fun.
You bet it's fun!! I love getting involved in this little sewing community.
I have been tempted to get this pattern - I do love the shoulder detail and the vintage vibe of this dress.
You did such an amazing job with this print (the bodice front is perfect)!
This is a great pattern to add to your stash!! It's such a cute and comfortable fit!
Perfect cutting of the fabric to get the birds - love the dress! Also, great job getting pics of the neck and pockets - you showcased them well. looks like there's some fun striped fabric hiding in those pockets!
Thankfully my daughter sat still looking through my book!


Beat to the Punch: Throw 250 punches within 30 seconds.
Ego Crusher: Throw 5,000 punches.
First Strike: Throw 100 punches.
Hard Hitter: Throw 1,000 punches.
Lumberjack Leader: Throw 500,000 punches.
Punch Prince: Throw 25,000 punches.


text:
Research GBB Molecular Microbiology Research Driessen group
Driessen group
Research Driessen Group
Protein translocation
Structure and Function of Secondary Transporters
BioInformatics & Membrane Proteins
Multidrug resistance
Protein translocation and membrane protein insertion are essential processes for the biogenesis of any living cell. In bacteria, the main route for protein secretion and membrane protein insertion is formed by the Sec-pathway. This system consists of the translocase, a multi-subunit protein complex. Its core is formed by a universally conserved trimeric integral membrane complex SecYEG which constitutes the protein-conducting channel, and the SecA protein which functions as an ATP-driven motor protein. SecA drives the stepwise translocation of pre-proteins across the membrane through multiple cycles of ATP binding and hydrolysis. The integral membrane proteins SecD, SecF and YajC form a sub-complex that associates with SecYEG and that add to the fidelity of protein secretion. YidC is a member of the conserved Alb3/Oxa1/YidC family, and contacts hydrophobic anchor sequences of membrane proteins during their insertion into the membrane. Whereas many secretory proteins are targeted to the translocase via the molecular chaperone SecB, membrane proteins mostly utilize a co-translational targeting route which involves bacterial homologs of the eukaryotic signal recognition particle and its membrane receptor.
Our aim is to elucidate the mechanism of preprotein translocation and the insertion of membrane protein complexes into the lipid bilayer. In both processes,we relate the structure of the translocase to its function with a focus on the dynamics of the process and the conformational changes during the reaction. The Escherichia coli translocase is used as a model system.
Research is directed at:
Macromechanics of protein unfolding during translocation and the role of SecA in this process
Functional and structural analysis of the SecYEG complex
Role of YidC in membrane protein insertion
For further reading and background information see:
Driessen, A.J.M., Nouwen, N. (2008) Protein translocation across the bacterial cytoplasmic membrane. Annu. Rev. Biochem . 77 :643-67.
Mitra, K., Frank, J., Driessen, A.J.M. (2006) Co- and Post-translational Translocation through the Protein-conducting Channel: Analogous Mechanisms at Work? Nat. Struc. Mol. Biol. 13: 959-966 .
Van der Laan, M. Nouwen, N.P., Driessen, A.J.M. (2005) YidC – an Evolutionary Conserved Device for the Assembly of Energy-transducing Membrane Protein Complexes. Curr. Opinion Microbiol. 8: 182-187.
Driessen, A.J.M. (2005) Cell Biology: Two Pores Better Than One? Nature 438: 299-300.
Last modified: 14 May 2019 12.04 p.m.