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Late availability offer: 25% off stays from July 2nd - 16th
Horne's Place Oast & Barn
The Old Church Hall
If you can tear yourself away from Horne's Place Oast & Barn, you'll find there's plenty to do in the local area – from country walks and wine tasting to family days out. There's plenty of information in the Welcome Book at the oast house but here's a taster...
Our star attraction: Gusbourne Vineyard
The vines you'll see close to the oast house belong to the Gusbourne estate. Their winery and tasting room, The Nest, is less than a mile from the oast house. You can take yourself on a self-guided tour of the vineyard any time, or book a guided two-hour tour and tasting. It's available 10am-5pm, Wednesday to Sunday but should be booked in advance.
Our recommendations for eating and drinking around Horne's Place Oast
Horne's Place Oast is on the edge of historic Appledore, a quaint village with a post office, antiques shop, pub, tea room and 13th-century church on the edge of the Royal Military Canal and Romney Marsh. The historic towns of Tenterden and Rye are within 10 miles, quaint Hythe and modern Ashford are within 15 miles with Canterbury, Folkestone and Dover all within 25 miles.
Romney, Hythe & Dymchurch Railway
The closest place to step aboard the miniature steam and diesel trains of the Romney, Hythe and Dymchurch Railway is at the New Romney Station. Take a train to Dymchurch for some seaside fun, to explore historic Hythe or to the end of the line at Dungeness. A great way to see the countryside of the Romney Marsh. There's also a museum and model railway at the New Romney station.
Kent & East Sussex Railway
Heritage railway, the Kent and East Sussex Railway has a station at Tenterden where you can step aboard their vintage trains. The tracks run through the beautiful countryside of the High Weald Area of Outstanding Natural Beauty to Bodiam, where you can disembark and visit the National Trust castle.
Chapel Down Vineyard
The 22-acre Chapel Down vineyard and winery is just eight miles from Horne's Place Oast, near Tenterden. Visitors can walk through the vineyard, visit the shop or dine at the vineyard's restaurant, The Swan. Guided tours of the vineyard and winery are also available but pre-booking is essential.
Bodiam Castle
The National Trust-protected Bodiam Castle is a 30-minute drive (about 15 miles) from Horne's Place Oast. It's a 14th century, moated castle with tea rooms and often has events on. If you don't fancy driving all the way, you can always head to Tenterden and hop aboard the Kent and East Sussex Railway to arrive by train.
If you're planning a group stay at Horne's Place Oast, why not plan some of your trips using the services of Scotland and Bates, our local coach company? It's especially good for larger groups hoping to visit Chapel Down vineyard or the Curious Brewery as no one has to take on the role of designated driver! Costs for a day's hire starts at £300.
The Rare Breeds Centre
Just a ten-minute drive from the oast house is The Rare Breeds Centre in Woodchurch. The centre is great fun for families and animal lovers with rare breeds of British farm animals, the chance to meet the animals in the barn, see falconry displays and enjoy tractor rides and pig racing in the summer.
Camber Sands and other nearby beaches
The closest beach is at Camber Sands where there are vast expanses of sand. In the summer the beach can be busy thanks to the holiday parks which are located around the village of Camber but there's plenty of space. There's also a sandy beach at Dymchurch where there are amusements and fun fair rides. For a shingle beach and a local fishmonger head for Hythe (pictured) or Dungeness.
Port Lympne Reserve
See lions, tigers, rhinos and gorillas at home at Port Lympne, a wild animal park that's part of the Aspinall Foundation's conservation programme. A safari experience gives you the chance to ride on an open-sided safari vehicle through an area of grassland where plains animals, including zebra and giraffe, wander freely. It also has a Dinosaur Forest with life-sized dinosaur models.
Curious Brewery
The Curious Brewery is the beer producing arm of Chapel Down. Their modern brewery in Ashford is 11 miles from Horne's Place Oast. The site welcomes visitors on brewery tours and tastings and also has an on-site bar and restaurant.
There are some lovely walks right outside the front door - starting with the short stroll to the Gusbourne Vineyard and Tasting Room. For a longer walk how about heading through Appledore and down to the Royal Military Canal or across the fields on the Saxon Shore Way to The Woolpack at Warehorne?
A private chef
For a special occasion dinner at Horne's Place Oast, how about letting someone else do the cooking? Kent-based private chef Silvestre Inácio is able to come to the property and cater a dinner party for up to 25 people. Take a look at his website, The Chef Touch, to find out about the range of menus available.
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Payless is about to enter the graveyard of retailers Opens a New Window. The company spokesperson confirmed to FOX Business Opens a New Window. it will begin a broad liquidation in the coming days. "Payless will begin liquidation sales at its U.S. and Puerto Rico stores on February 17, 2019, and is winding down its e-commerce operations. We expect all stores to remain open until at least the end of March and the majority will remain open until May. This process does not affect the Company's franchise operations or its Latin American stores, which remain open for business as usual" according to the statement. The discount shoe retailer, according to its website, has "nearly 3,600 stores in over 40 countries, Payless is a global brand" reads the description. It also states it is the "largest specialty family footwear retailer in the Western Hemisphere" which makes this process the largest ever for a retailer, as reported by Reuters. Payless has been dogged by liquidation rumors in recent weeks. On Thursday Reuters was first to report liquidation was imminent. Last year, it announced it would file for bankruptcy for the second time in two years, the company previously filed for bankruptcy in April 2017. Payless is hardly alone, store closures and retail bankruptcies are on the rise as e-commerce retailers such as Amazon Opens a New Window. continue to lure shoppers. While Sears avoided a massive liquidation, after CEO Eddie Lampert Opens a New Window. bid $5.2 billion for the bankrupt retailer he ran into the ground, many employees were not pleased he would still be controlling the company. Another retailer J.C. Penney Opens a New Window. is also struggling and recently outlined a new strategy to stay afloat.


Model of a brick house with an elaborate detailed gable and an extremely detailed roof tile structure.
Steam locomotive series 39.0-2 of the Deutsche Bundesbahn (DB). Epoch IIIa.
The model in classic DB design of the Epoch IIIb has big Witte smoke deflectors, silver boiler rings and a Prussian tender type 2\'2\' T 31,5.
The digital model is equipped with a built-in load sensing decoder.
Furnished driver\'s cab. Motor with fly wheel. Drive on 8 wheels in tender. Two wheels have traction tyres. Dual headlights on each end of the locomotive that change with the direction of travel. Automatic coupling on each end of the locomotive.
If you want to compose a typical Bundesbahn fast train of the early epoch III, simply use former prussian fast train coaches.
Electric locomotive Ae 6/6 \"Kantonslok\" of the SBB. Epoch IV-V.
Mold variant ! Technically and visually revised "canton locomotive" in red livery, with decorative stripes and Swiss emblem. Wrong-way-light replica (without function) and Swiss lighting arrangement.Closed front apron for optional mounting included.
In 1955 began the success story of the series Ae 6/6 and 120 locomotives were delivered to the SBB. The Ae 6/6 proved perfect for the quick transportation of the rapidly growing goods accumulation, particularly at the long steep ramps of the Saint Gotthard\'s pass. At that time the slow \"Crocodiles\" which operated on the frequently used lines were too slow and therefore lost too much time. So the shapely Ae 6/6 power pack easily replaced the \"Crocodile\" and other older locomotives on all inclined main lines. The Ae 6/6 achieved cult status during the last years of operation. After the decommissioning from the active service at the SBB, several locomotives have been preserved in museums for the next generations.
Metal die-cast chassis. Motor with flywheel. NEM 651 plug interface for the adaptation of decoders. 8 powered wheels, 2 of them with traction tyres. Current draw on all axles.
Triple LED headlights on both sides of the loco that change with the direction of travel. Close coupling mechanism on both sides of the loco for real close coupling if PROFI couplers 9545 are used (Delivery condition: Standards couplers). Coupler pockets according to NEM 355 standards. Closed front skirt is attached to the package.
Technically and visually revised model. The canton loco in true to the original red livery has a false light replica, Swiss light change and switchable DCC sound functions.
Model equipped with in-built load sensing digital decoder and true to the original sound functions from factory. Metal die-cast chassis. Motor with flywheel. 8 powered wheels, 2 of them with traction tyres. Current draw on all axles.
Triple LED headlights on both sides of the loco that change with the direction of travel. Brand new: Swiss light change. Close coupling mechanism on both sides of the loco for real close coupling if PROFI couplers 9545 are used (Delivery condition: Standards couplers). Coupler pockets according to NEM 355 standards. Closed front skirt is attached to the package.
Electric locomotive Ae 6/6 "Canton locomotive", SBB. Epoch III.
Model with built-in load sensing digital decoder and true to the original sound functions from factory.
Mold variant ! Technically and visually revised "canton locomotive" in green livery, with decorative stripes and Swiss emblem. Wrong-way-light replica (without function) and Swiss lighting arrangement.Closed front apron for optional mounting included.
Metal die-cast chassis. Motor with flywheel. Drive on 8 wheels. Two traction wheels. Power draw on all axles. Triple LED headlights on each end of the locomotive that change with the direction of travel. Close coupler motion link on both ends of the locomotive for real close coupling operation through the PROFI coupler 9545 (Delivery status: standard couplers). Coupler pocket according to NEM 355 standards.
Express coach 2./3. Class, type BC4ü (pr09), the Deutsche Bundesbahn (DB), epoch IIIa.
Model with interior decoration. Prepared for interior lighting. Coupling pocket according to NEM 355 with KK kinematics.
713901/713981, 804001, 878001, 878101, 878102.
Traction tire set N, 10 pieces.
Fits the models of the BR V 60 (DR east).
Corresponds to the part number 54700700.
Fits the models of the diesel engine of the BR VT 12/612 (DB).
Corresponds to the part number 54700900.
Fits the models of the diesel engine of the BR VT 11/601 (DB).
Corresponds to the part number 54701000.
Traction tire set N, 10 pieces. Outside diameter 8.8 mm, width 1.3 mm.
Corresponds to the part number 547004.
Traction tire set N, 10 pieces. Outer diameter 4.9 mm, width 1.2 mm.
Corresponds to the part number 547005.
Traction tire set N, 10 pieces. suitable for the models of the diesel engine of the BR VT 642 ("Desiro").
Corresponds to the part number 547006.
- The faithful reproduction of the actual vehicle specifications of the vehicle body 2 consolidated and 8-axis drive.
- I express accurately the beautiful coloring-a virile body, heavy truck around.
- Beautiful and represent the body and notation [Kintaro] logo.
- Adopt to the headlight high brightness white LED.
Graham Farish N gauge equipped with: engine, flywheel, English-style light change, digital interface, Finescale wheels, NEM coupler pockets, standard N-couplings, short-circuit link. Compatible with all commercially available N gauge track systems.
Graham Farish N gauge equipped with: Engine, Flywheel, Digital Interface, Finescale Wheels, NEM Coupler Sockets, Standard N Clutches, Short Coupling Bearing. Compatible with all commercially available N gauge track systems.


We will meet in the Publix parking lot across the street from Chateau Elan off of exit 126 on HWY 85 North at 12pm Friday May 28th.
the caravan will head up I-85 through Charlotte then swing North. We'll head directly to Dobson, then on to Mt. Airy.
let us know if you would like to join. at least 2 02s so far, plus a chase car e46.


A bit of bling mixed with a whole lot of edgy attitude in a sassy sandal that looks great with shorts or summery dresses. 1 1/2" heel. Synthetic. Available only in Natural.
Rockin' Sandal by Monroe and Main is rated 4.8 out of 5 by 5.
Rated 5 out of 5 by Lulis from Loved the style I just loved the style. I thought they would probably not fit because I'm a wide width, but they fit perfectly! and there so cute! The picture does not do them justice. So glad I purchased them!
Rated 5 out of 5 by Jayne from Classy Find I have not worn yet but love the feel and look.


With this news breaking on Friday it will get very little notice. So spread it around!
WASHINGTON — US officials say the United States is finalizing plans to evacuate several hundred Syrian civil defense workers and their families from southwest Syria as Russian-backed government forces close in on the area.
Two officials familiar with the plans said Thursday that the US, Britain and Canada are spearheading the evacuation that would transport members of the White Helmets group to transit camps in neighboring countries.
From there, they will be sent to third countries, including Britain, Germany, the Netherlands and possibly Canada, according to the officials who spoke on condition of anonymity because they were not authorized to publicly discuss the matter.
It was not immediately clear if Israel had any role in the operation. The IDF maintains its side of the Quneitra crossing, and has used it to transfer supplies to refugees as well as to evacuate wounded Syrians for medical care.
The evacuation is expected to take place from Quneitra, which straddles the frontier with the Golan Heights and where the civil defense team is trapped. It is the last sliver of land still outside government control in the region.
Sadly, US, Canada and Britain will rescue their thugs and relocate them.
Since the government offensive began in June, the area along the frontier with the Golan Heights has been the safest in the southwestern region, attracting hundreds of displaced people because is along the disengagement line with Israel demarcated in 1974 after the Yom Kippur War. The Syrian government is unlikely to fire there or carry out airstrikes.
On Tuesday, approximately 200 Syrians who were displaced by the recent onslaught approached the Israeli border, some of them waving white flags, in an apparent effort to get assistance from the Jewish state. Israel has refused to accept any refugees, including those seeking transfer to a third country.
Soldiers used bullhorns to tell them to back away from the fence.
I guess Israel was waiting for Canada, Britain and the US to come help with the evacuation?
"Syrian government supporters accuse the White Helmets, who only operate in opposition-held areas where government services are almost non-existent and aerial bombings are recurrent, of being politically affiliated with the rebel groups. Russia and the Syrian government have repeatedly accused them of staging chemical attacks in opposition areas, a charge that has never been proven.
They have continued to receive US support even as President Donald Trump presses ahead with his plans to withdraw all American forces from Syria as soon as Islamic State forces are routed"
In June, the State Department freed up a small portion — $6.6 million out of some $200 million — in frozen funding for Syria stabilization programs to keep the White Helmets operating through the end of this year.
In other parts of Syria, where government control has been restored, civil defense volunteers have almost always evacuated to other opposition-controlled areas. It is not clear why this time they will be evacuated out of the country.
This is disturbing news. Terrorism is rewarded by Canada, US & Britain. Sickening. Truly.
Send them to Hollywood and let George Looney take them in.
Or Bellingcat should take in some to his home.
It frightens me to think of these killers being here in Canada- pretty sure we've already got some of them here, under cover of the humanitarian refugee ruse.
Here in the USA we have enough home grown savages that I barely notice when we import some. The war zone is expanding to the city streets. It is only a matter of time. take care, Penny.
ISIS-RA-EL backed and helped these Amerikanazi-created vermin.They never attacked ISIS-RA-EL except accidently, which they apologized for. And so they should for all the Medical help wounded ISIS 'fighters' recieved from their benefactors.
Now these White Helmet scum might be coming to my Country?!!!
Another reason to rid ourselves of the Pentagram/Israeli influence over a once great Country and the Traitors in our so-called "Government".
If Putin DID make an arrangement with Trump to allow the White Helmets to escape, it would be the exact same policy as he and Assad have been implementing throughout Syria with the so-called "rebels". Under a Peace and Reconciliation strategy, Assad and Putin have been allowing the rebels to put down their rifles and move to de-escalation territories. This is the way they've been clearing out the lands infested by the terrorist groups and allowing the original Syrian inhabitants of those lands to return and begin reconstruction.
If that is what is going on with the White Helmets...I approve. Better than a bloodbath [or more False Flag chemical attacks] which Putin and Assad have been trying to avoid. Yes, I do believe many White Helmets will be coming to Canada...and they will disappear into the Canadian woodwork just like the thousands of Syrian refugees that have already come here under Trudeau.
This reconciliation is slightly different then what has been on going- Usually they lay down arms and go by bus to Idlib. Some of that is occurring.
But this exit is going through Israel and is geared to the White Helmets and their families.
I can't blame Syria for wanting them gone. Nor Russia for working out the deal.
I blame our government for this deal. These people should be in prison. They should walk no streets. And they should not walk Canada's streets.
I don't want them here in Canada. They are criminals. Thugs. Terrorists. Murderers. Rapists.
They will disappear until our government needs some convenient terrorists to cause discord here in Canada.
I fully realize Canada backed them and this is not the first bunch of thugs to come here- But as a Canadian- I don't want them here and free.
"...this is not the first bunch of thugs to come here..."
No. It is not. The Ukraine neo-Nazis that came here after WWII and spawned our Soros puppet Foreign Affairs Minister Chrystia Freeland comes to mind.
What happens is that Canada becomes an incubator for these extremists for decades until they can be re-utilized in another de-stabilization attempt by the same perps.
"Ukraine Neo-Nazis" to Canada after WW2???? I live in a southern Ontario city known to have taken in thousands of Polish and Ukranian immigrants, in the 40's and 50's. I have yet to meet one that could be described as Neo-anything! Do you or the vast majority of people reading even know what the word "Nazi" stands for, or what real National Socialist policies were? I guarantee you are only regurgitating what you hear from false information.
Stepan Bandera coming to Canada.
"By the time the Ukrainian Military Organization became the Organization of Ukrainian Nationalists (OUN), in 1929, a younger generation was dominant. Young terrorists such as Stepan Bandera were formed not by the prewar empires, but by fascist ideology and the experience of national discrimination in Poland. In the 1920s the Polish authorities had closed Ukrainian schools and ignored Poland's promise to provide for Ukrainian national autonomy. In the late 1920s and early 1930s, as a new Polish government sought reconciliation with its five million Ukrainian citizens, Ukrainian nationalists acted decisively to prevent any compromise settlement. Bandera was one of the main organizers of terror campaigns intended to prevent Ukrainians from accepting the Polish government by provoking Polish retaliation."
I count Ukranians as extended family on hubbies side- obviously most are not affiliated with terrorism- but some are.
'Nazi' became a catch word for denouncing any 'nationalism'. Its use is meant to obscure the fact that 'Nazism' was in fact a socialist movement.
"The full name of the party was Nationalsozialistische Deutsche Arbeiterpartei (English: National-Socialist German Workers' Party) for which they officially used the acronym NSDAP.
The term "Nazi" was in use before the rise of the NSDAP as a colloquial and derogatory word for a backwards farmer or peasant, characterizing an awkward and clumsy person. This was derived from Nazi a hypocorism of the German men's name Ignatz (itself a variation of the men's name Ignatius) – Ignatz being a common name at the time in Bavaria, the area from which the NSDAP emerged.
In the 1920s, political opponents of the NSDAP in the German labour movement seized on this and – using the earlier abbreviated term "Sozi" for Sozialist (English: Socialist) as an example – shortened the first part of the party's name, [Na]tionalso[zi]alistische, to the dismissive "Nazi", in order to associate them with the derogatory use of the term mentioned above.
After the NSDAP's rise to power in the 1930s, the use of the term "Nazi" by itself or in terms such as "Nazi Germany", "Nazi regime" and so on was popularised by German exiles. From them, the term spread into other languages and it was eventually brought back into Germany after World War II.
The Organization of Ukrainian Nationalists (OUN) (Ukrainian: Організація Українських Націоналістів, (ОУН), Orhanizatsiya Ukrayins'kykh Natsionalistiv) was just that, a nationalist organization with its own objectives which did not coincided with the objectives of German National Socialism. It is always conveniently forgotten that the OUN-B leaders and associates were arrested and imprisoned by the Gestapo (ca.1500 persons) in response to the Proclamation of the Ukrainian State. Bandera and Stetsko were arrested in September 1941 and later sent to Sachsenhausen concentration camp, where they have been kept until September 1944. They had nothing to suffer from the Nurnberg Tribunal. The Soviets denounced him for his collaboration with the Americans and British.
So Bandera, after originally siding with Germany against the Poles, because of nationalistic ideologies, collaborates with the Brits & Americans likely for those same nationalistic goals? Hence the Soviet denouncement?
Is this why we see some of the modern day Ukraines side with NATO in their overthrow of the elected government of the Ukraine in some misguided nationalistic belief?
ie: they actually believe NATO will give Ukraine independence?
Wizoz: "They had nothing to suffer from the Nurnberg Tribunal. "
what do you mean by that? they weren't tried?
something else? I don't know... sigh.
Indeed, Bandera was not tried, not even indicted, at Nurnberg nor at any subsequent trials. All 'fascists' have been tried for collaboration in their respective countries. Anyhow the Nurnberg Tribunal judged only war crimes.
After fleeing the advancing Soviet troops, he worked with several anti-communist organizations such as the Anti-Bolshevik Bloc of Nations as well as with the British intelligence agencies in order to carry actions of sabotage against the Soviets, once the 'West' suddenly was woken up by the noise of the 'fall of the Iron Curtain', realizing the dark designs of Stalin against the 'free world' and took action to 'contain' the Soviet aggression.
The insistence on presenting the situation in Ukraine as driven by 'Nazis' is a smokescreen to hide the real perpetrators.
I'm just sitting here waiting for a false flag blamed on Iran.
These white helmets need to be captured and fair trial. Kept alive and healthy in prison so they can continue to talk for years.
Yes of course our terrorists are already here in Canada and there will be many more coming returning from our lost war.
This is one of the reasons I live off grid and have a pack of Dobermans running loose here, they never leave the property but let us know if anybody is within 1/2 mile or near the trout lakes. Every time we go to town it reminds us how good we got it out here.
These white helmets should be tricked into thinking they are being rescued but droped off in Russia for trial. Fair trial broadcast in english world wide. Videos brought to UN. The world needs to know.
yes, they need to be captured and tried for the war crimes they undoubtedly committed- Many of them fully available for viewing on line.
I dont think we can blame Canadas current Govt or any western Govt for this mess. They have no power and make no decissions nor do they print their own money. Even Trump gets promply overruled.
They take orders or else.
Canada's current government includes a Foreign Affairs Minister who has a history of Nazism in her family, who own property in Kiev, and is extremely anti-Russia, not to mention that she is a close friend of George Soros. Canada may not be blameable for a lot of things, but appears guilty of not minding those things at all.
Penny: I finished my screed and directed readers to your current article. Thanks again for the added info!
All true. Even worse Canada goes out of their way to help get these wars started by agreeing with and sometimes bombing in the beginning. We back up the lies and deny the truth.
Were guilty of not even trying to do the right thing or careing.
sadly anonymous Canada does the "right thing" for advancing an agenda or for making profits- but morally speaking, Canada hasn't done the right thing for a long time, if ever.
If Canada was presently involved in Syria in a righteous manner they would not even be involved in Syria. Period.
and I hope you are as well as can be?
"The Israeli military said Sunday it was responsible for rescuing members of the Syrian volunteer organization from the volatile frontier area and evacuated them to a third country — the first such Israeli intervention in Syria's lengthy civil war."
In the Greek area- Interesting.
So, I'm off to read the news..
anywho off to see what I can find out..
Trump/Putin Press Conference: NO Deal!


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Alive couple 3 the background with green
The study by car parts firm Mister Auto covered the 100 cities with the most reliable and extensive data to create an accurate comparison.
A spokesman for Thames Water said: We're sorry to anyone who has had a longer journey than normal because of the road closure.
Cora and Hinch declined comment to The Athletic.
The 29-year-old has appeared in eight games this season, collecting an assist for his efforts.
Here's the distinction: Using this year's final BCS standings, the four best teams were Florida State, Auburn, Alabama and Michigan State.
This year, unfortunately, has been one of Rivers' more up-and-down seasons.
He was the one who had to get that last takeout, or the last sit and stay, or just put it on the button.
However, even after some driving, it only takes a couple of hours for the engine to cool down from full operating temperature, Calkins says.
11 jersey to the rafters of Rexall Place.
There's lots of kit in fact, with even the entry-level SE getting alloy wheels and trendy features including a flat-bottomed leather steering wheel.
Round 1: Josh Allen, OLB, Kentucky.
It's been a toll.
We sold 20 tickets and could have easily sold 80, said Jacobs.
Under NBA rules, a player or coach is automatically suspended without pay for one game once he receives his 16th technical foul during a regular season.
Back in 2013, the Ravens signed another pass rusher from Denver, Elvis Dumervil, who produced 26 ½ sacks over his first two seasons in Baltimore.
But the stars come and go, in step with our timescales.
As the most-nominated act at an event for a music genre dominated by its male performers, Morris has become one of the key female faces of country music.
Phi.: Recorded at least six tackles for the third time in his last four contests…Led the team in stops… vs.
The Game of FIITGCUSTOM Minkah Fitzpatrick Custom Jersey B082G2QTDS star and the pop crooner re-married at the Château de Tourreau in Provence, France, on June 29.
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redpajama_set_name: RedPajamaCommonCrawl


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HIV-1 damages gut antibody-producing immune cells within days of infection
DURHAM, N.C. - The virus that causes AIDS is classified as a lentivirus, a word derived from the Latin prefix, "lenti-," meaning "slow." But new research from the NIAID-funded Center for HIV/AIDS Vaccine Immunology suggests that HIV-1 is anything but - moving at breathtaking speed in destroying and dysregulating the body's gut-based B-cell antibody-producing system.
"These new data show that damage to the antibody arm of the immune system begins quickly, within days. We know that by 80 days, half of the generative microenvironments for antibodies within the immune system in the gut are destroyed," said Barton Haynes, M.D., director of the Center for HIV/AIDS Vaccine Immunology and the senior author of the study.
The study, published in the open access journal PLoS Medicine at http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.1000107, is the first to examine what happens to B cells in the gut in the earliest stage of HIV-1 infection. Researchers say the findings may shed light on one of the big mysteries in HIV: why the B cell, or antibody response, is so slow to arise - and so weak when it finally does, that it is unable to offer any kind of meaningful defense.
B cells that make antibodies against invading microbes are born in the bone marrow but migrate out and mature in different locations throughout the body. Some wind up in the intestine and settle in stretches of lymph node-like follicles called Payer's patches that are found at the bottom of the small intestine. (See: http://commons.wikimedia.org/wiki/File:Peyer%27s_Patches.jpg).
There, tucked inside the follicles' nurturing germinal centers, the B cells set up surveillance, waiting to rise up against incoming bacteria, viruses, or other pathogens. "Unfortunately, we found they are no match for HIV-1," said Anthony Moody, M.D. a member of the Duke Human Vaccine Institute (DHVI) and a lead author of the study.
Moody and co-lead author Marc Levesque, M.D., a former member of DHVI but now at the University of Pittsburgh, led a team of researchers in examining B cells in blood as early as 17 days after viral transmission, and in lymph tissue in the gut beginning at 47 days after transmission in 40 people infected with HIV-1. They compared their findings with similar tissue from healthy controls.
They discovered that even at this early stage, HIV-1 had already ravaged the gut's B cell arm of the immune system. The vast majority of the follicles in the Payer's patches had been damaged. "HIV-1 turns on the immune system, but turns it on in the wrong way," Moody said. "We found that it was churning out all sorts of B cells. Some appeared to be reactive against HIV-1, but others appeared reactive to things like influenza as well as self molecules."
In addition, the researchers found that by as early as 17 days after transmission, HIV-1 decreased the numbers of naïve B cells - cells that may have had the potential to mature into potent infection-fighters.
Such deregulation had been described in chronic HIV-1-infection, but never before in such an early phase of the disease, said Moody. "It is no wonder the B cell response is so weak in response to HIV-1 infection. The virus causes such early disruption that it is simply not able to work as it is supposed to. "It is really quite sobering."
The findings may be sobering, but they also reinforce the research team's vision of what a successful AIDS vaccine might look like.
"First, an effective vaccine will have to produce potent antibodies that would already be in circulation before infection occurs," said Haynes, who is also a professor of medicine and director of the Human Vaccine Institute at Duke. "Then, if the virus manages to escape that first line of defense, the vaccine would need to be able to educate the immune system to rapidly respond to eliminate transmitted virus strains. It is this continually emerging picture of what happens at the very earliest period after infection that is helping us to understand the job we have to do," Haynes said.
The study was funded by the National Institutes Health, National Institute of Allergy and Infectious Diseases, Division of AIDS.
Co-authors of the study from Duke include Kwan-Kid Hwang, Dawn Marshall, John Whiteside, Joshua Amos, Thaddeus Gurley, Sallie All good, Benjamin Haynes, Nathan Vandergrift, Steven Plunk, Charles Hicks, Hoaxing Liam, and Garnett Kelsey.
Co-authors from other institutions include Daniel Parker, Myron Cohen, Joseph Erin, David Margolis and Nicholas Shaken, from the University of North Carolina; Martin Markowitz, from the Aaron Diamond Research Center; George Shaw, from the University of Alabama and Jorn Schmitz from Beth Deaconess Medical Center.
Related Immune System Articles from Brightsurf:
How the immune system remembers viruses
For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen.
How does the immune system develop in the first days of life?
Researchers highlight the anti-inflammatory response taking place after birth and designed to shield the newborn from infection.
Memory training for the immune system
The immune system will memorize the pathogen after an infection and can therefore react promptly after reinfection with the same pathogen.
Immune system may have another job -- combatting depression
An inflammatory autoimmune response within the central nervous system similar to one linked to neurodegenerative diseases such as multiple sclerosis (MS) has also been found in the spinal fluid of healthy people, according to a new Yale-led study comparing immune system cells in the spinal fluid of MS patients and healthy subjects.
COVID-19: Immune system derails
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.
Immune cell steroids help tumours suppress the immune system, offering new drug targets
Tumours found to evade the immune system by telling immune cells to produce immunosuppressive steroids.
Immune system -- Knocked off balance
Instead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies.
Too much salt weakens the immune system
A high-salt diet is not only bad for one's blood pressure, but also for the immune system.
Parkinson's and the immune system
Mutations in the Parkin gene are a common cause of hereditary forms of Parkinson's disease.
How an immune system regulator shifts the balance of immune cells
Researchers have provided new insight on the role of cyclic AMP (cAMP) in regulating the immune response.
Read More: Immune System News and Immune System Current Events


Please enjoy this Conscious Evolution Meditation.
Saturday I did a podcast about Barbara Marx Hubbard, an author and speaker who created a large path around the idea of Conscious Evolution and 'birthing a new humanity" and left her body last week.
We then did a very beautiful and deep guided meditation to declare and align ourselves to CONSCIOUSLY EVOLVING and being a conscious creator of our own lives.
I got many messages after it like "Thank you for that meditation, it was exactly what I needed today…" so be sure to enjoy the podcast replay >here<.
We are really in a moment in time where we are waking up to the fact we ARE the creators and we ARE the ones who have to raise our awareness and STATE and MASTER our emotions (our power) so we can consciously create the world we want to live in.
Do you get depressed, anxious or disappointed in the current state of affairs in the world, or politics or healthcare…?
Do you find it hard to keep your mood up and your thought positive when around certain people, or when thinking about money or career?
There is 1 CURE for it, and only 1! MASTER YOUR ENERGY!
I am serious about this. You can seek all kinds of fixes or try to force your way through (like most of us were taught) mentally and physically working harder or trying to please everyone. In the end the energy you enter your creation with will affect the outcome. It's taken me 30 years, and now I know the way – really well.
What I discovered after 30+ years on a conscious path of evolution and true 'healing' – for myself and for my clients and students is – IT'S ALL ENERGY.
How would it feel it you KNEW you could intentionally raise your STATE of consciousness in the moment (like from guilt or anger to acceptance or joy)?
Imagine not worrying if you will be able to speak your truth or handle conflict or difficult situations?
I create experiences based on my 30 years of expertise as a master level hypnotherapist, a Dr of Homeopathy and a Master Energy healer… to empower YOU to understand and connect to your true power, your power to change your energetic STATE.
1 – LIVE in person: You could come to an Epic BlissLife equinox retreat, these are the fastest way to change, and are the most concentrated and deep. There is a SUPER EARLY BIRD Price and 5 month payment plan available right now.
2 – ONLINE trainings & LIVE Calls: Also in my online and in person Energy Mastery School "LightBody School" we learn and experience first hand the secrets to mastering and directing energy. This means in any situation you can change the atmosphere, the relationship, how you feel, think… and the outcome!
It also means you can feel more powerful confident, present, calm… and best of all happy with yourself! LightBody school helps you learn how to LIVE LIFE on your terms!
3 – LIVE in person: LightBody School has a LIVE Crystal Vortex experience that is incredible and mind blowing… in the vast crystal beds and vortex of Hot Springs Arkansas – we learn, practice and accelerate our healing with the crystals… check it out here – we go in July 13-16. There is no prerequisite for the retreat and you also get the entire Infinity Light Weaving course to start ASAP so you can start right now!
4 – 1-1: I also – on occasion – take on private clients or do readings and deep sessions with people. Take a peek here or hit reply to the email and let's chat. I am only interested in working with you if it is OPTIMAL for both of us at this time"… so if I am not the optimal person for you, I will tell you.
Between the online school trainings and live healing and teaching calls, and the interactive tribe and opportunity to work with me at all of the above options in small groups and interactive ways… you will have deep transformations and healings.
I honor you for being here at this time… it is an epic moment for humanity, and believe it or not – WE ARE THE CREATORS OF TOMORROW!
Take back your power of creation by mastering and rewiring your beliefs, emotions and thoughts… and FLOW with the MOMENT.
This is the time to talk to me – maybe one short session will do the trick to get you aligned with your next steps… I am free this Thursday and Friday for a chat or a personal reading or private session, so hit reply and let Donna know you want to chat.
I see so many people KNOW they are meant to be at these retreats and events, and yet do not reach out and get help to figure it out. As the event comes closer, the inner voice gets louder, and so does the fear… and then at the last minute they listen to their inner voice saying "GO!"… and then the overwhelm becomes an issue.
Why not support yourself and your growth and sign up now and give yourself time, and my suport to find the money, the help, the time off? You will also get to be in the energies of the Soul family and work we do ALL YEAR preparing to the next event! … whatever you need for your highest good WILL BE POSSIBLE… it is just cometies you cannot see the path… and I can.
Let me be your guide and join our Soul family.. we are a ton of fun and all about amazing experiences, lots of love, and big transformation.


text:
Nicholas Rees
Bahamian swimmer
Why Is Nicholas Rees Influential?
According to Wikipedia , Nicholas Rees is a Bahamian former swimmer, who specialized in butterfly events. He is a two-time Olympian , a former Caribbean and Bahamian record holder in the 100 m butterfly, a varsity swimmer for the Ohio State Buckeyes, and a graduate of business administration at Ohio State University. Rees later obtained an MBA in International Business from the University of Miami. Nicholas Rees is also the grandson of Lionel Wilmot Brabazon Rees, VC, British war hero, Victoria Cross recipient and advisor to the Crown.
Other Resources About Nicholas Rees
What Schools Are Affiliated With Nicholas Rees?
Nicholas Rees is affiliated with the following schools:


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Sam got caught up on his vaccinations yesterday without any issues so we are still clear to leave the hospital tomorrow. Yesterday we spent some time unpacking Sam's bedroom, cleaning the house, and playing outside as a family. Ryan had a blast being at home with Mom and Dad.
Today we have a care conference scheduled to discuss the plan for tomorrow and to go over any questions that we have regarding his care. We are very anxious to get home, but terrified at the same time of all that we need to learn and manage at home. I am sure that within a few weeks everything will be second nature to us.


The Cummins Family wishes you a happy and healthy new year. May 2017 bring you all of your dreams.
Thank you for choosing Cummins Chiropractic to be a part of your health care team. We are honored and privileged to help you reach for your optimum health potential. We call this Gold Medal Health. We hope 2017 is your best year yet and look forward to partnering with you to reach your health goals in 2017.
Begin with YOUR 100 Year Lifestyle in mind.
Change is easy. Thinking about change is hard.
Want to learn more? We are sponsoring a "Healthy New You" Special Event on Tuesday evening, January 31st at 7pm and hope you and your friends can attend. Based on the principles of the international best selling books The 100 Year Lifestyle and The 100 Year Lifestyle Workout, this powerful presentation will inspire, help and energize you.
We wish you and yours a happy and healthy new year!


text:
Printed from https://ideas.repec.org/p/hum/wpaper/sfb649dp2010-044.html
The High Sensitivity of Employment to Agency Costs: The Relevance of Wage Rigidity
Atanas Hristov
This paper studies the interaction of financing constraints and labor market imperfections on the labor market and economic activity. My analysis builds on the agency cost framework of Carlstrom and Fuerst [1998. Agency costs and business cycles. Economic Theory, 12(3):583-597]. The aim of this article is to show that financing constraints can substantially amplify and propagate total factor productivity shocks in cyclical labor market dynamics. I find that under the Nash bargaining solution financing constraints increase substantially the volatility of wages, and in turn, amplification for the labor variables falls short of the observed volatilities in the data. Atop of this, the comovement between output and labor share is counterfactual. However, there is substantial scope for any type of wage rigidity and financing constraints to reinforce each other, and to generate the observed volatilities in the labor market, moreover, to produce a wide range of comovements between output and labor share.
Atanas Hristov, 2010. "The High Sensitivity of Employment to Agency Costs: The Relevance of Wage Rigidity," SFB 649 Discussion Papers SFB649DP2010-044, Sonderforschungsbereich 649, Humboldt University, Berlin, Germany.
Handle: RePEc:hum:wpaper:sfb649dp2010-044
File URL: http://sfb649.wiwi.hu-berlin.de/papers/pdf/SFB649DP2010-044.pdf
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Petrosky-Nadeau, Nicolas & Wasmer, Etienne, 2015. "Macroeconomic dynamics in a model of goods, labor, and credit market frictions," Journal of Monetary Economics, Elsevier, vol. 72(C), pages 97-113.
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Nicolas Petrosky-Nadeau & Etienne Wasmer, 2014. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Working Papers hal-01073540, HAL.
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Nicolas Petrosky-Nadeau & Etienne Wasmer, 2015. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Post-Print hal-03392977, HAL.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2014. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Sciences Po Economics Discussion Papers 2014-09, Sciences Po Departement of Economics.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2011. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Sciences Po publications info:hdl:2441/5l6uh8ogmqi, Sciences Po.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2015. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Sciences Po publications info:hdl:2441/5por5bt92h8, Sciences Po.
Petrosky-Nadeau, Nicolas & Wasmer, Etienne, 2011. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," IZA Discussion Papers 5763, Institute of Labor Economics (IZA).
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2014. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," Sciences Po publications 2014-09, Sciences Po.
Imen Ben Mohamed & Marine Salès, 2015. "Credit imperfections, labor market frictions and unemployment: a DSGE approach," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) hal-01082491, HAL.
Imen Ben Mohamed & Marine Salès, 2015. "Credit imperfections, labor market frictions and unemployment: a DSGE approach," Working Papers hal-01082471, HAL.
Nicolas Petrosky-Nadeau, 2013. "Code and data files for "Credit, Vacancies and Unemployment Fluctuations"," Computer Codes 12-42, Review of Economic Dynamics.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2019. "Welfare Cost of Fluctuations When Labor Market Search Interacts with Financial Frictions," Journal of Money, Credit and Banking, Blackwell Publishing, vol. 51(8), pages 2207-2237, December.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2014. "Welfare Cost of Fluctuations: when Labor Market Search Interacts with Financial Frictions," Post-Print halshs-01020872, HAL.
Eleni Iliopulos & Francois Langot & Thepthida Sopraseuth, 2019. "Welfare Cost of Fluctuations When Labor Market Search Interacts with Financial Frictions," Working Papers hal-02334103, HAL.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2017. "Welfare Cost of Fluctuations when Labor Market Search Interacts with Financial Frictions," Documents de recherche 17-02, Centre d'Études des Politiques Économiques (EPEE), Université d'Evry Val d'Essonne.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2014. "Welfare Cost of Fluctuations: when Labor Market Search Interacts with Financial Frictions," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) halshs-01020872, HAL.
Thepthida Sopraseuth & François Langot & Eleni Iliopulos, 2016. "Welfare Cost of Fluctuations when Labor Market Search Interacts with Financial Frictions," 2016 Meeting Papers 890, Society for Economic Dynamics.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2018. "Welfare Cost of Fluctuations. When Labor Market Search Interacts with Financial Frictions," TEPP Working Paper 2018-13, TEPP.
Eleni Iliopulos & François Langot & Thepthida Sopraseuth, 2014. "Welfare Cost of Fluctuations: when Labor Market Search Interacts with Financial Frictions," Documents de travail du Centre d'Economie de la Sorbonne 14042, Université Panthéon-Sorbonne (Paris 1), Centre d'Economie de la Sorbonne.
Meradj Mortezapouraghdam, 2016. "Three Essays on the Role of Frictions in the Economy," Sciences Po publications info:hdl:2441/293qice3lj8, Sciences Po.
Liu, Zheng & Miao, Jianjun & Zha, Tao, 2016. "Land prices and unemployment," Journal of Monetary Economics, Elsevier, vol. 80(C), pages 86-105.
Zheng Liu & Jianjun Miao & Tao Zha, 2013. "Land prices and unemployment," FRB Atlanta Working Paper 2013-06, Federal Reserve Bank of Atlanta.
Tao Zha & Jianjun Miao & Zheng Liu, 2015. "Land Prices and Unemployment," 2015 Meeting Papers 1118, Society for Economic Dynamics.
Zheng Liu & Jianjun Miao & Tao Zha, 2013. "Land Prices and Unemployment," Working Paper Series 2013-22, Federal Reserve Bank of San Francisco.
Zheng Liu & Jianjun Miao & Tao Zha, 2013. "Land Prices and Unemployment," NBER Working Papers 19382, National Bureau of Economic Research, Inc.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2013. "The Cyclical Volatility of Labor Markets under Frictional Financial Markets," American Economic Journal: Macroeconomics, American Economic Association, vol. 5(1), pages 193-221, January.
Nicolas Petrosky-Nadeau & Etienne Wasmer, "undated". "The cyclical volatility of labor markets under frictional financial markets," GSIA Working Papers 2010-E1, Carnegie Mellon University, Tepper School of Business.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2010. "The Cyclical Volatility of Labor Markets under Frictional Financial Markets," Sciences Po publications info:hdl:2441/5l6uh8ogmqi, Sciences Po.
Petrosky-Nadeau, Nicolas & Wasmer, Etienne, 2010. "The Cyclical Volatility of Labor Markets under Frictional Financial Markets," IZA Discussion Papers 5131, Institute of Labor Economics (IZA).
Nicolas Petrovsky-Nadeau & Etienne Wasmer, 2010. "The Cyclical Volatility of Labor Markets under Frictional Financial Markets," Working Papers hal-00972916, HAL.
Garín, Julio, 2015. "Borrowing constraints, collateral fluctuations, and the labor market," Journal of Economic Dynamics and Control, Elsevier, vol. 57(C), pages 112-130.
Finkelstein Shapiro, Alan & Olivero, Maria Pia, 2020. "Lending relationships and labor market dynamics," European Economic Review, Elsevier, vol. 127(C).
Alan Finkelstein Shapiro & Maria Olivero, 2018. "Lending Relationships and Labor Market Dynamics," 2018 Meeting Papers 1113, Society for Economic Dynamics.
Finkelstein Shapiroy, Alan & Olivero, Maria, 2018. "Lending Relationships and Labor Market Dynamics," School of Economics Working Paper Series 2018-5, LeBow College of Business, Drexel University.
Neele Balke, 2018. "The Employment Cost of Sovereign Default," 2018 Meeting Papers 1256, Society for Economic Dynamics.
Zhang, Yahong, 2018. "Financial factors and labor market fluctuations," Economic Modelling, Elsevier, vol. 74(C), pages 24-44.
Yahong Zhang, 2011. "Financial Factors and Labour Market Fluctuations," Staff Working Papers 11-12, Bank of Canada.
Nicolas Petrosky-Nadeau & Etienne Wasmer, 2014. "Macroeconomic Dynamics in a Model of Goods, Labor and Credit Market Frictions," SciencePo Working papers hal-01073540, HAL.
Feng Dong, . "Aggregate Implications of Financial Frictions for Unemployment," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics.
Yashiv, Eran, 2007. "Labor search and matching in macroeconomics," European Economic Review, Elsevier, vol. 51(8), pages 1859-1895, November.
Yashiv, Eran, 2007. "Labor Search and Matching in Macroeconomics," IZA Discussion Papers 2743, Institute of Labor Economics (IZA).
Yashiv, Eran, 2007. "Labor search and matching in macroeconomics," LSE Research Online Documents on Economics 19707, London School of Economics and Political Science, LSE Library.
Eran Yashiv, 2007. "Labor Search and Matching in Macroeconomics," CEP Discussion Papers dp0803, Centre for Economic Performance, LSE.
Dromel, Nicolas L. & Kolakez, Elie & Lehmann, Etienne, 2010. "Credit constraints and the persistence of unemployment," Labour Economics, Elsevier, vol. 17(5), pages 823-834, October.
Nicolas L. Dromel & Elie Kolakez & Etienne Lehmann, 2009. "Credit constraints and persistence of unemployment," Documents de travail du Centre d'Economie de la Sorbonne 09032, Université Panthéon-Sorbonne (Paris 1), Centre d'Economie de la Sorbonne.
Nicolas Dromel & Elie Kolakez & Etienne Lehmann, 2010. "Credit Constraints and the Persistence of Unemployment," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) halshs-00640674, HAL.
Nicolas Dromel & Elie Kolakez & Etienne Lehmann, 2010. "Credit Constraints and the Persistence of Unemployment," PSE-Ecole d'économie de Paris (Postprint) halshs-00640674, HAL.
Dromel, Nicolas & Kolakez, Elie & Lehmann, Etienne, 2009. "Credit Constraints and the Persistence of Unemployment," IZA Discussion Papers 4501, Institute of Labor Economics (IZA).
Nicolas Dromel & Elie Kolakez & Etienne Lehmann, 2010. "Credit Constraints and the Persistence of Unemployment," Post-Print halshs-00640674, HAL.
Credit and search frictions; Labor market; Unemployment;
E32 - Macroeconomics and Monetary Economics - - Prices, Business Fluctuations, and Cycles - - - Business Fluctuations; Cycles
J64 - Labor and Demographic Economics - - Mobility, Unemployment, Vacancies, and Immigrant Workers - - - Unemployment: Models, Duration, Incidence, and Job Search
G24 - Financial Economics - - Financial Institutions and Services - - - Investment Banking; Venture Capital; Brokerage
NEP-BEC-2010-09-18 (Business Economics)
NEP-DGE-2010-09-18 (Dynamic General Equilibrium)
NEP-LAB-2010-09-18 (Labour Economics)
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SWEETWATER — Belinda Lee Amaral, 48, of Sweetwater, passed away May 19, 2018, at Rolling Plains Memorial Hospital. There will be a memorial service at 7 p.m. Wednesday, May 23, 2018, at Faith Harvest Church. She was cremated.
ABILENE — Fridrich Baumgardt, 81, passed away Saturday, May 19, 2018. Cremation services are pending, under the direction of Elliott-Hamil Funeral Home. Interment will be in Texas State Veterans Cemetery at Abilene at a later date.
ABILENE — James A. Brown, 73, passed away Sunday, May 20, 2018. A committal service will be at 2 p.m. Wednesday, May 23, 2018, at Texas State Veterans Cemetery at Abilene, directed by The Hamil Family Funeral Home.
CLYDE — Henry David Childers, 58, passed away Sunday, May 20, 2018. Services are pending with Girdner Funeral Home, of Abilene.
ANSON - Rudy Hernandez, 43, passed away Saturday, May 19, 2018 in Abilene. Services are pending with Adams-Graham Funeral Home, of Anson.
STAMFORD — Maria Mendoya, 89, passed away Sunday, May 20, 2018. Funeral service will be at 11 a.m. Wednesday, May 23, 2018 at the Tankersley Funeral Home chapel, with burial following in Highland Memorial Cemetery. Family will be receiving friends from 5 to 7 p.m. Tuesday at funeral home, 807 S. Columbia St.
COMANCHE — Willie Mae Niemann, 84, passed away Saturday, May 19, 2018. Service will be at 10 a.m. Tuesday, May 22, 2018, in the Heartland Funeral Home chapel. Interment will follow in St. John's Cemetery in Priddy. Family greeted friends from 5 to 7 p.m. Monday, May 21, 2018, at the funeral home.
HAMLIN — Ronnie Shoemaker, 71, passed away on Saturday, May 19, 2018. Service will be at 10 a.m. Saturday, May 26, 2018, at First Baptist Church. Burial will follow in Hamlin Memorial Cemetery. Visitation will be from 5 to 6 p.m. Friday, May 25, 2018, at the Adams-Foster-Ray Funeral Home chapel.
ABILENE — Lawrence Edward "Larry" Tatum, 60, passed away Sunday, May 20, 2018. The family will receive friends from 7 to 9 p.m. Wednesday, May 23, 2018, at The Hamil Family Funeral Home, 6449 Buffalo Gap Road. A memorial service will be at 10:30 am Thursday at First Central Presbyterian Church.


The Momentum is Sennheiser's series of premium portable headphones for the fashion-conscious crowd. While there is an undeniable whiff of Beats envy in the series, as that's pretty much the same target audience that Beats caters to, being Sennheiser, the Momentum products didn't at least sound terrible.
A live photo of Samsung Galaxy S6 Duos made showed up on Twitter. Earlier this week, the dual-SIM version of the hot new flagship appeared in a Russian online store listing.
Now that the One M9 is up for order in the US, HTC decided it would be fit for it to start its marketing campaign for the handset in the UK. Hence, the Taiwanese smartphone maker has released its first TV ad for the One M9 in the UK.
As most of our US reader are surely aware, the eagerly-anticipated Samsung Galaxy S6 and S6 edge are finally up for preorder today. The devices can be picked-up from a wide variety of vendors, including AT&T, Sprint, T-Mobile, US Cellular and Verizon, which carry both devices, as well as Boost, Cricket and MetroPSC, which only have the basic S6 model.
If you have been using WhatsApp for Web lately, then you would know how convenient it is to access the messages, send voice notes and more via web interface. That freedom is being missed by the loyal Skype users but Microsoft plans to fix that soon.
Samsung removed the microSD card slot from its latest Galaxy S6 flagship, but it did upgrade the base storage to 32GB. How much storage do you get on a 32GB phone, anyway?
Qualcomm seems to be pretty proud of its Quick Charge 2.0 technology, that is an integral part of some high-end smartphones which use its top of the line chipsets. The Motorola Nexus 6 is in this situation, and Qualcomm has used this particular device in a new promotional video for Quick Charge 2.0.
With a rumored announcement in April, the LG G4 is the next big-name flagship to come this year. Inspired by intensifying leaks, designer Ivo Maric headed for the drawing board and came up with a very appealing concept of how the upcoming high-end smartphone might look.
The original 4G-capable Moto G from last year is now being offered by Motorola with a pretty neat price reduction. Normally retailing for $199.99, the phone can be yours for just $159.99 – but you have to act fast.
The Galaxy S6 and S6 edge are well on their way to consumer markets and with a record number of preorders piling up, both retailers and users are quite eager to get their hands on the Latest Samsung tech. There is, however, still some waiting to be done, as in most regions the two handsets will become available around the middle of April.


Which 'Wet Hot American Summer' scenes are based on real-life crazy camp stories?
The original Wet Hot was written by Michael Showalter and David Wain, who found inspiration for their camp-movie send-up in their own camp experiences at Camp Modin in Maine and Camp Mohawk in Massachusetts, respectively. While reporting our story on the return to Camp Firewood – which can be found in the latest issue of EW – we asked the WHAS: FDOC creators/executive producers/stars to share the craziest story that happened to them while at camp. As it turns out, Showalter's gastrointestinal tale of terror served as the basis for a scene that you will see in the prequel, while a version of Wain's crash-and-burn tale showed up in the movie.


This book is dedicated to disruption, innovation, and transformation. As the real hero in this journey, this book is dedicated to you. My intention is to introduce you to your connected customers, demonstrate how they progress through a dynamic customer journey, and how they behave in each moment of truth. Part entitlement, part egotism, part DIY (do it yourself), and part entrepreneurialism, Generation C'ers' behavior is indeed dissimilar to that of their more traditional counterparts.


text:
George Harrison - Live In Japan (1992) [England, Pop Rock]
Artist: George Harrison
Album: Live In Japan
Genre: Pop Rock
Duration: 42:29 + 44:47 (Double Live Album)
Recorded live bwteen 1–17 December 1991 in Japan.
All tracks written by George Harrison, except where noted.
01. I Want To Tell You - 4:33
02. Old Brown Shoe - 3:50
03. Taxman - 4:15
04. Give Me Love (Give Me Peace On Earth) - 3:37
05. If I Needed Someone - 3:50
06. Something - 5:21
07. What Is Life - 4:47
08. Dark Horse - 4:20
09. Piggies - 2:56
10. Got My Mind Set On You (Rudy Clark) - 4:56
01. Cloud Nine - 4:23
02. Here Comes The Sun - 3:31
03. My Sweet Lord - 5:41
04. All Those Years Ago - 4:26
05. Cheer Down (Harrison, Tom Petty) - 3:53
06. Devil's Radio - 4:25
07. Isn't It A Pity - 6:32
08. While My Guitar Gently Weeps - 7:08
09. Roll Over Beethoven (Chuck Berry) - 4:45
- George Harrison – lead vocals, rhythm guitar, lead guitar, slide guitar, acoustic guitar, producer
- Eric Clapton – lead guitar, acoustic guitar, backing vocals
- Andy Fairweather Low – guitar, backing vocals
- Nathan East – bass, backing vocals
- Chuck Leavell – piano, Hammond organ, keyboards, backing vocals
- Greg Phillinganes – keyboards, backing vocals
- Steve Ferrone – drums
- Ray Cooper – percussion, drums
- Katie Kissoon – background vocals
- Tessa Niles – background vocals
Download: AnonFiles
1992 Andy Fairweather-Low England Eric Clapton George Harrison Nathan East Pop Rock


In the Gazette dated 29th October 1955, it was announced to Partners that a new building had been acquired on the corner of Palmerston road, which would house the new Knight and Lee premises.
The new shop would sell Piece Goods, Hardware, Bedding, and Stationary, Leather Goods, amongst other things. In addition to these new premises, Knight and Lee opted to continue to trade in four of its current shops. These four shops would hold a number of departments, including Fashion and Casual Wear, Baby linen and Childrenswear, and Men and Boyswear. This way, the store could continue to offer all of its existing services without having to compromise.
The brand new Knight and Lee was opened on the 24th September 1956, 15 years after being burned to the ground. On the previous weekend, havoc had ensued as there was a rush to get everything ready, and stock flittered between three sites. Finally, at the end of a very successful first day's trading, the celebrations commenced.
The new shop was a grand affair, an ocean from the shop of the 1930's. The new premises were completed in their entirety in 1959. Many of the exiled departments had by this point come in from the cold. The only department to remain apart from the main store was the 'Men and Boyswear'.


text:
Q: scala foreach of a 2-D List/Array in chisel with types issue Can "foreach" can be used for each element of the 2-D List/Array?
I tried the code:
val n_vec = (0 to 2).map(i=>
              (0 to 2).map(j=>
                Wire(UInt(3.W))
              )
            )
n_vec.foreach((i:Int)=>(
  n_vec(i).foreach((j:Int)=>{
    n_vec(i)(j) := i.U + j.U
  })
))

the error message is
top.scala:24: error: type mismatch;
 found   : Int => Unit
 required: chisel3.core.UInt => ?
      n_vec(i).foreach((j:Int)=>{
                              ^

Could you enlight me whether it can be used in such a way, even how?

A: It would be cleaner to write like this:
n_vec.foreach { i=>
  i.foreach { j=>
    j := x.U + y.U
    y = y + 1
  }
  y = 0
  x = x + 1
}

But you don't need to increment x and y manually, just iterate over indices instead:
n_vec.indices.foreach { x =>
  n_vec(x).indices.foreach { y =>
    n_vec(x)(y) := x.U + y.U
  }
}

or better (and this translates exactly to the above)
for {
  x <- n_vec.indices
  y <- n_vec(x).indices
} {
  n_vec(x)(y) := x.U + y.U
}

A: Yes it can be used this way.
solution:
var x = 0
var y = 0
n_vec.foreach(i=>{
  i.foreach(j=>{
    j := x.U + y.U
    y = y + 1
  })
  y = 0
  x = x + 1
})
x = 0
y = 0

redpajama_set_name: RedPajamaStackExchange


text:
namespace Sitecore.Ecommerce.Data.ModelConfiguration
{
  using System.Data.Entity.ModelConfiguration;
  using Ecommerce.OrderManagement.Orders;

  /// <summary>
  /// Defines the price configuration class.
  /// </summary>
  public class PriceConfiguration : EntityTypeConfiguration<Price>
  {
    /// <summary>
    /// Initializes a new instance of the <see cref="PriceConfiguration"/> class.
    /// </summary>
    public PriceConfiguration()
    {
      this.HasKey(o => o.Alias);
      this.Property(p => p.PriceTypeCode).HasMaxLength(Constants.BigCodeFieldLength);
    }
  }
}

redpajama_set_name: RedPajamaGithub


text:
Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification
Charles Hwang, Simone Marini, Amanda K. Huber, David M. Stepien, Michael Sorkin, Shawn Loder, Chase A. Pagani, John Li, Noelle D. Visser, Kaetlin Vasquez, Mohamed A. Garada, Shuli Li, Jiajia Xu, Ching Yun Hsu, Paul B. Yu, Aaron W. James, Yuji Mishina, Shailesh Agarwal, Jun Li, Benjamin Levi
Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.
Bone Research
Dive into the research topics of 'Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification'. Together they form a unique fingerprint.
Heterotopic Ossification Medicine & Life Sciences 100%
Vascular Endothelial Growth Factor A Medicine & Life Sciences 65%
Osteogenesis Medicine & Life Sciences 26%
Nervous System Trauma Medicine & Life Sciences 18%
Bone and Bones Medicine & Life Sciences 18%
Blood Vessels Medicine & Life Sciences 17%
Bone Development Medicine & Life Sciences 16%
Orthopedic Procedures Medicine & Life Sciences 16%
Hwang, C., Marini, S., Huber, A. K., Stepien, D. M., Sorkin, M., Loder, S., Pagani, C. A., Li, J., Visser, N. D., Vasquez, K., Garada, M. A., Li, S., Xu, J., Hsu, C. Y., Yu, P. B., James, A. W., Mishina, Y., Agarwal, S., Li, J., & Levi, B. (2019). Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Research, 7(1), [36]. https://doi.org/10.1038/s41413-019-0075-6
Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. / Hwang, Charles; Marini, Simone; Huber, Amanda K. et al.
In: Bone Research, Vol. 7, No. 1, 36, 01.12.2019.
Hwang, C, Marini, S, Huber, AK, Stepien, DM, Sorkin, M, Loder, S, Pagani, CA, Li, J, Visser, ND, Vasquez, K, Garada, MA, Li, S, Xu, J, Hsu, CY, Yu, PB, James, AW, Mishina, Y, Agarwal, S, Li, J & Levi, B 2019, 'Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification', Bone Research, vol. 7, no. 1, 36. https://doi.org/10.1038/s41413-019-0075-6
Hwang C, Marini S, Huber AK, Stepien DM, Sorkin M, Loder S et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Research. 2019 Dec 1;7(1):36. doi: 10.1038/s41413-019-0075-6
Hwang, Charles ; Marini, Simone ; Huber, Amanda K. et al. / Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. In: Bone Research. 2019 ; Vol. 7, No. 1.
@article{efba1dcc69754534bddfc93fbe308107,
title = "Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification",
abstract = "Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.",
author = "Charles Hwang and Simone Marini and Huber, {Amanda K.} and Stepien, {David M.} and Michael Sorkin and Shawn Loder and Pagani, {Chase A.} and John Li and Visser, {Noelle D.} and Kaetlin Vasquez and Garada, {Mohamed A.} and Shuli Li and Jiajia Xu and Hsu, {Ching Yun} and Yu, {Paul B.} and James, {Aaron W.} and Yuji Mishina and Shailesh Agarwal and Jun Li and Benjamin Levi",
note = "Funding Information: We would like to thank Christopher Breuler, Caitlin Priest, Serra Ucer, and the University of Michigan Orthopaedic Research Laboratories for their technical assistance. We also thank the Department of Radiology at The University of Michigan for the use of The Center for Molecular Imaging and The Preclinical Imaging & Computational Analysis Shared Resource which are supported in part by Comprehensive Cancer Center NIH grant P30 CA046592. We also thank to the University of Michigan Biomedical Research Core Facilities and the DNA sequencing core. Funding Information: Competing interests: A.W.J. serves on the scientific advisory board for Novadip LLC and also receives laboratory financial support from MTF Biologics for research unrelated to the current project. All other authors declare no competing interests.. Funding Information: B.L.: Supported by funding from NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH1R01AR071379 and American College of Surgeons Clowes Award. D.M.S.: Supported by Plastic Surgery Foundation Resident Research Award. M. S.: Supported by Plastic Surgery Foundation National Endowment Award. C.H.: Supported by Howard Hughes Medical Institute Medical Research Fellowship. J.L.: Supported by Vascular Surgery T32 5-T32-HL-076123–14. A.W.J.: Supported by the NIH/NIAMS (R01 AR070773, K08 AR068316, S10OD016374), the Orthopedic Research and Education Foundation with funding provided by the Maryland Stem Cell Research Foundation, and the Musculoskeletal Transplant Foundation. P.B.Y.: Supported by funding from NIH/NIAMS R01 AR057374 and NHLBI R01 HL131910. Y.M.: Supported by funding from NIH/NIDCR R01 DE020843 and DE027662 Funding Information: Ethics statement All animal experiments described were approved by the University Committee on Use and Care of Animals at the University of Michigan, Ann Arbor (Protocols: #05909 and 07930). This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.59 All animal procedures were carried out in accordance with the guidelines provided in the Guide for the Use and Care of Laboratory Animals: Eighth Edition from the Institute for Laboratory Animal Research.60 Publisher Copyright: {\textcopyright} 2019, The Author(s).",
journal = "Bone Research",
T1 - Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification
AU - Hwang, Charles
AU - Marini, Simone
AU - Huber, Amanda K.
AU - Stepien, David M.
AU - Sorkin, Michael
AU - Loder, Shawn
AU - Pagani, Chase A.
AU - Li, John
AU - Visser, Noelle D.
AU - Vasquez, Kaetlin
AU - Garada, Mohamed A.
AU - Li, Shuli
AU - Xu, Jiajia
AU - Hsu, Ching Yun
AU - Yu, Paul B.
AU - James, Aaron W.
AU - Mishina, Yuji
AU - Agarwal, Shailesh
AU - Li, Jun
AU - Levi, Benjamin
N1 - Funding Information: We would like to thank Christopher Breuler, Caitlin Priest, Serra Ucer, and the University of Michigan Orthopaedic Research Laboratories for their technical assistance. We also thank the Department of Radiology at The University of Michigan for the use of The Center for Molecular Imaging and The Preclinical Imaging & Computational Analysis Shared Resource which are supported in part by Comprehensive Cancer Center NIH grant P30 CA046592. We also thank to the University of Michigan Biomedical Research Core Facilities and the DNA sequencing core. Funding Information: Competing interests: A.W.J. serves on the scientific advisory board for Novadip LLC and also receives laboratory financial support from MTF Biologics for research unrelated to the current project. All other authors declare no competing interests.. Funding Information: B.L.: Supported by funding from NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH1R01AR071379 and American College of Surgeons Clowes Award. D.M.S.: Supported by Plastic Surgery Foundation Resident Research Award. M. S.: Supported by Plastic Surgery Foundation National Endowment Award. C.H.: Supported by Howard Hughes Medical Institute Medical Research Fellowship. J.L.: Supported by Vascular Surgery T32 5-T32-HL-076123–14. A.W.J.: Supported by the NIH/NIAMS (R01 AR070773, K08 AR068316, S10OD016374), the Orthopedic Research and Education Foundation with funding provided by the Maryland Stem Cell Research Foundation, and the Musculoskeletal Transplant Foundation. P.B.Y.: Supported by funding from NIH/NIAMS R01 AR057374 and NHLBI R01 HL131910. Y.M.: Supported by funding from NIH/NIDCR R01 DE020843 and DE027662 Funding Information: Ethics statement All animal experiments described were approved by the University Committee on Use and Care of Animals at the University of Michigan, Ann Arbor (Protocols: #05909 and 07930). This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.59 All animal procedures were carried out in accordance with the guidelines provided in the Guide for the Use and Care of Laboratory Animals: Eighth Edition from the Institute for Laboratory Animal Research.60 Publisher Copyright: © 2019, The Author(s).
N2 - Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.
AB - Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.
JO - Bone Research
JF - Bone Research


Questions » How will people be saved during the tribulation?
Question: If the Holy Spirit is taken out at the rapture, how will people be saved during the tribulation?
People will be saved during the tribulation the same way they have always been saved – through the ministry of the Holy Spirit.
Firstly, the Holy Spirit is not taken out of the world at the rapture. Many people today believe that the Holy Spirit will be removed from the earth during the rapture along with the believers. They base this teaching on 2 Thessalonians 2:7-9 where it says that before the coming of the Antichrist, the One who restrains him will be "taken out of the way".
2 Thes 2:7-9 (KJV) "7 For the mystery of iniquity doth already work: only he who now letteth will let, until he be taken out of the way.
If we look at those verses carefully we see that the Bible does not say that the Holy Spirit will be removed from the earth. It only states that He will be taken out of the way – i.e. no longer restrain the Wicked, who is the Antichrist. Therefore there is no reason to believe that the Holy Spirit will not be present on Earth after the rapture. That would be going beyond what the Bible says and entering into error.
The Holy Spirit is God (Acts 5:3-4). He is not limited only to dwelling in believers, He is omnipresent (Psalm 139:7-8). By His very nature it is impossible for Him to be in one physical space and not in another.
Bezaleel the son of Uri, the son of Hur, of the tribe of Judah was filled with the spirit of God, according to God Himself.
Seventy men prophesied when the Spirit came upon them (Numbers 11:16-25 KJV).
The Holy Spirit came upon Saul and caused him to prophesy.
Another wonderful proof that the Holy Spirit will continue to do His work of convicting people of their sins and leading them to faith in Christ is that many people who will be saved during the tribulation – the tribulation saints. The Bible says these are the ones who will resist the Antichrist and will not take the sign of the Beast (Revelation 13:15). The tribulation saints will be martyred for their faith but will live and reign with Jesus in His millennial kingdom (Revelations 20:4). Also the remnant of Israel, the 144000 Jews, will be saved during the tribulation (Revelation 7:4).
Thus the argument that the Holy Spirit was given to the world only at Pentecost is invalid and we can be sure of His presence in the world even during the tribulation period.
Our God is a gracious and loving God. Even during the tribulation, He will continue to reach out to people, wanting them to turn back to Him. The Gospel will be preached through the two witnesses (Revelation 11:3), through the 144000 Jews and through the rest of the Gentile believers who will believe during that time. God will also send His angel to preach the gospel to the whole world (Revelation 14:6-7).
Therefore, we can be sure that the Holy Spirit will continue His saving work during the tribulation. Note that the Bible does not say whether people who be saved during the tribulation will be indwelled by the Holy Spirit or whether they will be like the Old Testament believers, although this is a possibility. We trust this answer has helped you to understand the end times better.
Was it God's plan from the beginning for Jesus to die for the sins of mankind?