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Built in the 1960s, the Albergo Carcani opened its doors in April 2012 after a complete renovation.
The Ascona interior designer Carlo Rampazzi has channelled with his unique colour combinations the Ticino's bright sunshine into the premises and created a Mediterranean ambiance. Under his guidance the hotel is continuously being renovated. As a result of this, the Tea Room presents itself in an elegant silver grey and on the sun terrace extraordinary tables as well as palm and olive trees provide the typical 'Italianità'.
'Dolce far niente' – spend time where life is beautiful on Ascona's piazza at the Albergo Carcani!


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BMW X7 Launched in New Renderings, Confirmed for Official Launch in 2019
by Eduard Huma —	April 25, 2016
The BMW X7 is back into our spotlights in some new renderings signed by the folks over OmniAuto magazine, with some in-depth detailing concerning its official release and the powertrains it will come with under the hood.
According to OmniAuto, the BMW X7 is indeed confirmed for an official debut in 2019, the biggest SUV ever built by BMW, starting production in South Carolina, at Spartanburg plant.
Once it will emerge at its dealerships, the X7 will be available from at least $145,000 which is way too much than the 7-Series` entry-level price of $81,300.
As you probably know from our previous posts, the X7 will be previewed by the launch of the X5 flagship, also coming bigger and wider than the previous generation and underpinning the same CLAR platform as the future X7. Both models will come with extremely lightweight materials which will make them extremely spacious inside.
Speaking about size inside, the BMW X7 will be coming with a seven-seat displacement, followed by the most luxurious SUV ever offered, with just a four-seat arrangement. According to the same auto magazine, the rear passengers will have heating, ventilation and massaging functions, along with the most advanced entertainment systems available and equipped with navigation, audio and so on.
But perhaps the SUV`s main highlight would be the engine lineup it will come with, reports also mentioning the presence of a massive 6.6-liter V12 engine, also found on the 2016 BMW 7-Series. The V12 engine will join the others from the club, like the V8 and six-cylinder petrol burners and diesels, present on the future X5 as well.
Once it will emerge on the market, the BMW X7 will take on the Mercedes-Benz GLS or Land Rover Range Rover.
Tags: bmw / BMW X5 / bmw x7 / New rendering / Official launch in 2019
Author: Eduard Huma
All-New BMW X5 and X7 Will Share the Same Platform BMW is getting bigger: new rumors on X7 SUV BMW 2018 X7 Confirmed, i8 Spyder and 7-Series Derivatives not in Plans BMW X7 Might Cost 125,000 Euros in Europe BMW X7 SUV Planned, Might Be Based on the Vision Future Luxury Concept
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Meet the social enterprises helping to fix products, people and communities
Naturesave
The Naturesave Trust funds a wide variety of projects covering renewable energy, nature conservation, sustainable food and social welfare. Another key area of funding is recycling and repair, in this update we highlight some of the recent funding projects undertaken by the Trust.
We think repair cafes are beautiful things and we want to see one in every community, which is why The Trust was delighted to help Repair Café Wales open three new Repair Cafes and provide them with the regular personal support and materials a local group needs to establish themselves.
The concept of repair cafés started in Amsterdam, and there are now over 1,800 of them across the world. The great thing about this simple concept is that repair cafés deliver a series of multiple benefits that really make them a win-win-win.
Firstly they tackle our serious consumer waste problem. If we just take electronics, the world disposes of an estimated 50 million tonnes of e-waste every year. Aside from the toxic pollution this produces, this is an extraordinary waste of precious resources. When it comes to clothes the numbers are just as eye watering. In the UK we threw away £12.5 billion worth of clothes last year, which ended up with 300,000 tonnes of textiles going to landfill. Repair cafés tackle this problem head on. This ultimately reduces the volume of raw materials and energy needed to make new products and cuts CO2 emissions by reusing instead of manufacturing new products.
Tackling this tsunami of waste, reducing pollution, cutting CO2 and protecting our reserves of raw materials are not the only benefits delivered by repair cafés. They also deliver social and community benefits too. By promoting a repairing culture and inviting visitors to sit with a volunteer repairer, repair cafés show appreciation for the people who have practical knowledge, the result is that these valuable skills are passed on within the community. Finally, repair cafés play an important role in helping to improve social cohesion within communities. Inviting local residents to bring along their broken and damaged items, helps connect residents from very different backgrounds. You can read more about this project here.
The Trust recently supported a charity working in a similar way with household furniture. Now! Charity is the community-driven social enterprise dedicated to tackling key environmental and social issues across Sussex. They are dedicated to taking on the two critical causes of reducing waste and tackling inequality. They highlight that every year, we dispose of at least 3 million household items that are readily reusable. The charity prevents these items from going to landfill, through either repair or upcycling, and redistributes them to people of low socioeconomic status. Along the way, they also deliver wonderful life-changing and transformative opportunities to their volunteers, many of whom were previously experiencing issues such as homelessness or suffered from mental health issues. A lovely quote that sums up their work is "We impact lives in multiple ways, often triggered by a single piece of essential furniture". You can read more about this project here.
Another enterprising charity the Trust has worked with recently is RAW Workshop, a social enterprise that makes high-quality furniture from waste timber. RAW runs a Wood Recycling service offering a professional waste wood collection and recycling service to developers, housebuilders and local authorities. In the process, the charity reduces carbon emissions, increases reuse rates and creates significant human social impact with a workforce made up mostly of people who had previously fallen on hard times. Raw's aim is to 'create opportunities for people who have walked challenging life-paths whilst also contributing to the circular economy'. A grant from the Trust enabled the charity to expand its recycling operation.
Finally, ReRun Clothing, a Community-interest-company aimed at prolonging the life of running clothes and equipment.
Founded and run by Dan Lawson, Team GB 24hr Ultra runner, together with his wife Charlotte, Rerun is on a mission to make running equipment more sustainable.
They highlight that the average life of a running shoe on our feet is only four-six months. If sent to landfill they then hang around for a further 11,994 months before starting to decompose. In addition, they point out that currently, over 5% of the UK's total annual carbon and water footprint results from clothing consumption. Extending the average life of clothes by just 3 months would result in a 5 to 10% reduction of both carbon and water. Going further, by extending life by 9 months would result in a 20 to 30% reduction.
The Trust was delighted to help provide equipment to enable Rerun to help repair clothing and trainers which you can read about here. You might also be interested to know that founder Dan Lawson recently ran from Land's End to John o' Groats in 9 days, 21 hours, 14 minutes and 2 seconds, setting the fastest time ever recorded.
The Naturesave Trust receives 100% of its donations from the activities of Naturesave Insurance. The Trust has three core activities, grants for environmental projects, a tree-planting program and a long-running campaign to help small to medium-sized businesses become more sustainable.
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Financial Ombudsman Service, Exchange Tower, London E14 9SR. Website: www.financial-ombudsman.org.uk
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Ryan Madson
#50 - Los Angeles Dodgers
Date vs S/R Res Score IP H R ER K BB HR P P/IP GB:FB
10/27/18 BOS R H 6-9 0.2 1 1 1 0 0 1 8 12.0 .00
10/26/18 BOS R 3-2 0.1 0 0 0 0 0 0 2 6.0 .00
10/24/18 @ BOS R 2-4 0.1 1 0 0 1 1 0 12 36.0 .00
10/20/18 @ MIL R W 5-1 1.2 1 0 0 2 0 0 22 13.2 1.00
10/17/18 MIL R 5-2 0.1 2 1 1 0 0 0 9 27.0 .00
10/16/18 MIL R 2-1 1.1 1 0 0 1 0 0 14 10.5 .00
10/13/18 @ MIL R 4-3 0.2 0 0 0 1 1 0 5 7.5 .00
10/12/18 @ MIL R 5-6 1.0 1 0 0 1 0 0 14 14.0 .00
10/8/18 @ ATL R W 6-2 0.2 0 0 0 0 0 0 10 15.0 .00
10/7/18 @ ATL R 5-6 0.2 1 0 0 1 0 0 7 10.5 .00
9/29/18 @ SF R 10-6 1.0 0 0 0 1 0 0 11 11.0 1.00
9/26/18 @ ARI R 2-7 1.0 1 0 0 2 0 0 13 13.0 .00
9/21/18 SD R 3-5 1.1 1 1 1 1 0 1 18 13.5 2.00
9/16/18 @ STL R 0-5 0.2 0 0 0 2 0 0 11 16.5 .00
9/15/18 @ STL R 17-4 1.0 0 0 0 1 0 0 13 13.0 .00
9/10/18 @ CIN R 6-10 1.0 4 3 3 3 0 0 31 31.0 .00
9/5/18 NYM R 3-7 1.0 3 2 2 1 0 0 24 24.0 .00
9/2/18 ARI R BS 3-2 0.2 0 0 0 1 1 0 14 21.0 .00
8/27/18 @ PHI (WAS ) R H 5-3 1.0 1 1 1 1 0 1 11 11.0 1.00
8/12/18 @ CHC (WAS ) R L, BS 3-4 0.2 2 4 4 0 0 1 21 31.5 .00
8/9/18 ATL (WAS ) R 6-3 1.0 2 1 1 1 0 0 16 16.0 .00
8/5/18 CIN (WAS ) R H 2-1 1.0 0 0 0 2 0 0 12 12.0 .00
8/4/18 CIN (WAS ) R 6-2 1.0 0 0 0 0 0 0 17 17.0 .00
8/1/18 NYM (WAS ) R H 5-3 1.0 1 1 1 1 0 1 18 18.0 .00
7/28/18 @ MIA (WAS ) R 1-2 1.0 0 0 0 1 0 0 9 9.0 .00
7/26/18 @ MIA (WAS ) R H 10-3 1.0 1 0 0 2 0 0 18 18.0 .00
7/24/18 @ MIL (WAS ) R 4-5 1.0 1 0 0 0 1 0 13 13.0 .00
7/22/18 ATL (WAS ) R H 6-2 0.1 1 0 0 0 0 0 6 18.0 .00
7/15/18 @ NYM (WAS ) R 6-1 1.0 0 0 0 1 1 0 16 16.0 1.00
7/12/18 @ NYM (WAS ) R SV 5-4 1.0 1 0 0 0 0 0 9 9.0 .00
7/10/18 @ PIT (WAS ) R 5-1 1.0 0 0 0 0 0 0 8 8.0 .00
7/8/18 MIA (WAS ) R 2-10 0.2 4 4 4 0 2 0 32 48.0 .00
7/6/18 MIA (WAS ) R 3-2 1.0 0 0 0 0 1 0 14 14.0 1.00
7/4/18 BOS (WAS ) R L 0-3 1.0 2 2 1 0 1 0 25 25.0 .50
7/1/18 @ PHI (WAS ) R 3-4 0.1 0 0 0 1 0 0 5 15.0 .00
6/30/18 @ PHI (WAS ) R 2-3 1.0 0 0 0 1 0 0 9 9.0 .00
6/28/18 @ PHI (WAS ) R 3-4 0.2 2 2 2 1 0 1 16 24.0 .00
6/24/18 PHI (WAS ) R W 8-6 1.0 1 0 0 0 0 0 10 10.0 .00
6/23/18 PHI (WAS ) R 3-5 1.0 0 0 0 1 1 0 11 11.0 .00
6/17/18 @ TOR (WAS ) R L 6-8 1.0 2 2 2 2 0 2 24 24.0 .00
6/13/18 @ NYY (WAS ) R H 5-4 1.0 1 0 0 1 1 0 22 22.0 .00
6/9/18 SF (WAS ) R H 7-5 1.0 3 1 1 2 0 0 14 14.0 .00
6/2/18 @ ATL (WAS ) R 5-3 1.0 0 0 0 1 0 0 7 7.0 .00
6/1/18 @ ATL (WAS ) R 0-4 0.1 0 0 0 0 1 0 10 30.0 .00
5/15/18 NYY (WAS ) R H 5-3 1.0 2 0 0 0 0 0 12 12.0 .00
5/13/18 @ ARI (WAS ) R W 6-4 1.1 0 0 0 2 0 0 15 11.2 .00
5/12/18 @ ARI (WAS ) R SV 2-1 1.0 0 0 0 1 0 0 13 13.0 .00
5/10/18 @ ARI (WAS ) R 2-1 1.1 0 0 0 3 1 0 23 17.2 .00
5/8/18 @ SD (WAS ) R H 4-0 0.1 0 0 0 0 0 0 2 6.0 .00
5/4/18 PHI (WAS ) R 7-3 1.0 1 0 0 1 0 0 8 8.0 .00
5/3/18 PIT (WAS ) R H 3-1 0.1 1 1 0 1 0 0 16 48.0 .00
4/30/18 PIT (WAS ) R H 3-2 1.0 0 0 0 0 0 0 9 9.0 1.00
4/28/18 ARI (WAS ) R BS 3-4 1.0 3 1 1 1 0 0 16 16.0 .00
4/27/18 ARI (WAS ) R 4-5 0.2 0 0 0 0 0 0 3 4.5 .00
4/24/18 @ SF (WAS ) R 3-4 1.0 0 0 0 0 0 0 10 10.0 .50
4/18/18 @ NYM (WAS ) R L, BS 5-11 0.2 5 6 6 1 1 0 26 39.0 .00
4/17/18 @ NYM (WAS ) R H 5-2 1.0 2 0 0 2 0 0 21 21.0 .00
4/16/18 @ NYM (WAS ) R SV 8-6 1.0 1 0 0 1 0 0 11 11.0 .00
4/14/18 COL (WAS ) R 6-2 1.0 1 0 0 1 1 0 23 23.0 .00
4/11/18 ATL (WAS ) R L 3-5 1.0 3 2 2 2 2 0 20 20.0 .00
4/10/18 ATL (WAS ) R SV 4-1 0.2 1 0 0 1 0 0 11 16.5 .00
4/8/18 NYM (WAS ) R 5-6 1.0 1 0 0 0 0 0 11 11.0 .00
4/1/18 @ CIN (WAS ) R H 6-5 1.0 0 0 0 0 0 0 7 7.0 .00
3/30/18 @ CIN (WAS ) R H 2-0 1.0 2 0 0 1 0 0 19 19.0 .00


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Q: Run pc windows program on Linux running thru harddrive? I am dyslexic and as a result of living in the UK am provided with a laptop and related programs (such as Dragon Natural speak etc) for my university studies. The problem is I typically run ubuntu thru an external harddrive plugged into my laptop. Is there any way that I can use the programs saved on the 'windows' part of my laptop when I am running ubuntu? Needless to say I don't want to have to buy the programs separately or do anything illegal.

A: Unfortunately, most applications installed on Windows are not "portable" - i.e., after installing them on one operating system, you can't just boot another operating system and run the installed program.
The reason is that the application is not only the program file on the drive - it is also its "registry" settings, it may install libraries into the operation system itself, maybe some configuration and so on. This is specifically true for applications like a dictation software that needs to hook into all kinds of dark corners of the operating system to support "typing" into other applications.
Dragon Naturally Speaking can - theoretically1 - be run under Linux using the Wine compatibility wrapper - see the Dragon Naturally Speaking WineHQ AppDB entry for details - as some versions work better than others, but you'd need to actually install another copy of Dragon into your Linux operating system using Wine, and for that you'd need access to the license details.
I'm not familiar with the specific program under which you have received a Dragon Naturally Speaking license, but if under that program you are entitled to a license key and not just a single installation, then you should be able to install two copies under the same license - as it is the same computer.
1 I have never tried this myself.

A: If your laptop is powerful, say with a quad-core processor and plenty of RAM, then you might consider running one OS or the other in a virtual machine.  (I don't know about other virtualization software, but in VirtualBox the user designates how many processor cores and how much RAM the virtual machine gets, and when the virtual machine is running the host OS doesn't have the use of those resources.)  You could copy-and-paste text from Naturally Speaking to a program running in Ubuntu, although that process would be somewhat clumsy, because extra keystrokes would be required to move from the host OS to the client OS, and vice-versa.  Still, it could be done; if I were you, I'd want to dictate a paragraph or two before copying to the other OS, rather than copying one sentence at a time.
Assuming that your laptop is sufficiently powerful, it wouldn't be too difficult to try installing virtualization software in Windows and then create a new installation of Ubuntu in a virtual machine.  You could keep the file for the virtual hard disk in your external hard drive.  There is a bit of a learning curve involved when running virtualization software, but I personally found it to be very worthwhile.  (Like I found experimenting with Ubuntu to be worthwhile, ha ha.)
There is an interesting Wikipedia article about speech recognition software for Linux here, which discusses several of these points.
EDIT: If you can make Simply Speaking work through Wine, then that would be a great way to go.  It can be a real pain to make programs work with Wine though...  There is also a commercial product, CrossOver Linux, that seems to be a fancy version of Wine, or a better way to set up Windows programs in Wine.  That might be worth checking out.  Good luck!

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The audio recordings and visual images that captured the military operation in Londonderry on 30 January 1972, in and around the Bogside area of William Street and Rossville flats, were real eye openers to the escalating dangers and civil unrest across the province as a whole.
As a young junior soldier I was very aware of the Troubles across the water from mainland Britain as many of our adult instructors had served tours of duty in the province since 1969 and had shared first-hand graphic images of their experiences with us. The sounds and pictures now beaming from our NAFFI TV were those of the civil rights march and disorder forming the never-to-be forgotten Bloody Sunday. Thirteen unarmed civilians were killed and many others seriously wounded as a result of the action taken by 1 Para.
As a young 15-year-old these images would bring the soldier's experience out in the province right into our hearts, minds and psyche forever. I can remember seeing marchers running everywhere trying to get away from the gunfire of the Paras and using anything that seemed solid enough to take cover behind to protect themselves. I can vividly remember hearing the CO of the Paras instructing his men to cease firing and to control their shots, or words to that effect; the sounds and images shown on television were awful and depicted mayhem, disorder and sheer panic amongst civilians as well as the soldiers. For me it was the most disturbing reality of the anger and lawlessness that existed at the time which had built up over centuries but created by the modern troubles and tensions from 1969 onwards. I can remember talking to a number of lads from different regiments who were watching the TV and we all realised that in a little over eighteen months or so many of us would be posted to Northern Ireland to face similar circumstances, not a welcome thought.
My heart went out to both the civilians and the SF that day as the circumstances were so violent and changing that the reality of what was happening must have been so difficult to gauge.


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Coronavirus News Rest of World World News
Honduran Cardinal Oscar Rodriguez Maradiaga tests positive for COVID-19
CNA Staff, Feb 5, 2021 / 03:00 am MT (CNA).- The Archdiocese of Tegucigalpa said on Thursday that Cardinal Óscar Rodríguez Maradiaga has tested positive for COVID-19 and is "stable and recovering" at a local private clinic.
Fr. Rodolfo Varela, spokesman for the Honduran archdiocese, announced on Feb. 4 that Maradiaga, 78, felt "some flu-like symptoms on Tuesday and tested positive for COVID on Wednesday."
"He is stable and recovering, but resting at the clinic upon the request of his doctor," Fr. Varela added in a statement released by the Catholic television station TV Suyapa.
"The cardinal has asked Honduran Catholics to pray for him, but to turn their attention to all the people currently suffering from COVID in the country."
Fr. Juan Ángel López, director of TV Suyapa, said: "The cardinal is diabetic and is 78 years old, so we have to take his condition seriously. He is now in the hands of Our Lady of Suyapa [Patroness of Honduras]."
The television station broadcast a Holy Rosary on Thursday night to pray for the cardinal's swift recovery.
Cardinal Maradiaga is the coordinator of the Council of Cardinals, created in 2013 by Pope Francis to help him reform the Roman Curia and advise him in the government of the universal Church.
The council currently has seven members and has met 34 times since it was created. It is currently discussing the final draft of a new apostolic constitution on the Curia entitled "Praedicate evangelium" ("Preach the Gospel").
Honduras, with a population of 10 million, has registered more than 151,000 infected and almost 4,000 deaths from COVID-19.
Image: Cardinal Óscar Andrés Rodríguez Maradiaga at a press conference May 12, 2015. Credit: Daniel Ibáñez/CNA.
Tags Cardinal Oscar Rodríguez Maradiaga coronavirus COVID-19
Cardinal Müller critiques Pope Francis' 'harsh' response to extraordinary form, compared to German Synodal Way
Breaking: Pope Francis issues restrictions on extraordinary form Masses in new motu proprio
Spanish medical body: Threat to conscientious objection on abortion 'unacceptable, illegal, and unjust'
Vatican economy council meets in person to discuss investment policy
Pope Francis returns to Vatican after colon surgery
Priest beaten, arrested amid Cuba protests
Pope Francis to visit Scotland 'for a very short time' in November
La Crosse bishop removes Father Altman from ministry


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Trangé ist eine französische Gemeinde mit  Einwohnern (Stand: ) im Département Sarthe in der Region Pays de la Loire; sie gehört zum Arrondissement Le Mans und zum Kanton Le Mans-7 (bis 2015: Kanton Le Mans-Nord-Ouest). Die Einwohner werden Trangéens genannt.

Geographie
Trangé liegt etwa sechs Kilometer westnordwestlich von Le Mans. Umgeben wird Trangé von den Nachbargemeinden Aigné im Norden, La Milesse im Nordosten, La Chapelle-Saint-Aubin im Osten, Le Mans im Osten und Südosten, Rouillon im Süden und Südosten, Pruillé-le-Chétie im Süden, Fay im Südwesten sowie Chaufour-Notre-Dame im Westen.

Durch die Gemeinde führen die Autoroute A11 und Autoroute A81.

Bevölkerungsentwicklung

Sehenswürdigkeiten
 Kirche Saint-Gervais-et-Saint-Protais
 Schloss La Groirie, seit 1974 Monument historique

Gemeindepartnerschaften
Mit der britischen Gemeinde Dunston in Lincolnshire (England) besteht eine Partnerschaft.

Weblinks

Ort in Pays de la Loire

redpajama_set_name: RedPajamaWikipedia


Burn off your belly fat and turn off your fat genes with these best-ever tips.
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The general manager serves as the chief operating officer for the Cordillera Metro District (CMD) and the Cordillera Property Owners Association (CPOA). The general manager provides oversight and guidance to departments in developing and implementing the annual work plans and directing departments on daily operations. The general manager serves as the main point of contact for the Boards of Directors, scheduling meetings and coordinating the production of Board and Committee materials and minutes.
The communications office works to strategically maximize exposure of Cordillera while simultaneously increasing awareness of and user-ship of Cordillera amenities and social offerings. It plans and manages community events that offer exposure to the community. The office coordinates and sustains all aspects of internal and external communications, including public relations, press releases and a diverse array of print/electronic publications in effort to facilitate transparency and encourage the exchange of information between the boards and property owners.
The human resources office serves to guide and manage the overall delivery of Human Resources services policies and programs for the CMD including recruiting and staffing; departmental planning; performance management and improvement systems; payroll; employment and compliance to regulatory concerns regarding employees; employee on-boarding, development, needs assessment and training; policy development and documentation; employee relations; compensation and benefits administration; employee safety, welfare, wellness and health; and employee services and counseling.
The Information and technology office manages technology systems including deployment, maintenance, monitoring of servers, PCs, operating systems, telephones, software applications gate systems and community access control. The office works with team members to develop strategies and plans to enhance services, improve user effectiveness, foster innovation and maximize capacity with the greatest efficiency.
0408 Carterville Road


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SOM Talk Live
DJ Luke Nasty | Talks New Music, Success, & More!
Rueben Wood interviews Dj Luke Nasty on his new ep and success of his records. After the release of his certified Gold hit "Might Be" last year, Luke's newest single "OTW" is on track to deliver the same accolade. The single broke top 10 at Urban mainstream radio with the video receiving more than 2M views so far and counting. Now, Luke is opening the doors to 'Boom Boom Room,' his newest EP that dropped today. According to Luke, the project is meant to provide hope. In fact, that's precisely what inspired the effort's Boom Boom Room title. "One of my favorite movies is Life starring Eddie Murphy and Martin Lawrence," says Luke. "Eddie had this idea of this club called the Boom Boom Room and it was just his thing that kept him going. It was a dream. What really got inspiring was him telling people about it gave them hope. That's what I hope my music and movement does," said Luke.
Dr. Dre's Son | Curtis Young Tells How He Met His Dad
WCW With SOM Talk Live: Queen Lee | Talks Nursing, Modeling, Health & More!
by SOM Talk Live
WCW With SOM Talk Live: Becky Stallion | Talks Modeling, What She Wants In A Man , & More!


SEGA sent over a photo today of the newly announced Collector's Edition for the upcoming Aliens: Colonial Marines developed by Gearbox Studios. The Collector's Edition comes with a Resin Powerloader Figure and exclusive Alien Hive enclosure case for the game.
In addition to the physical additions, players will also get access Ripley's Flamethrower, two exclusive multiplayer weapons, more customization options for in-game Marines, an exclusive level, and a variety of dossiers on various USCM related things.
In addition to the Collector's Edition, GameStop will give out exclusive pre-order bonuses, which include 4 playable Marines from the film Aliens, including Hicks, Drake, Hudson and Apone (sorry Vasquez fans!).
More details in the full press release below, along with a shot of the Collector's Edition contents.
SAN FRANCISCO (May 31, 2012) – SEGA® of America, Inc., Gearbox Software and Twentieth Century Fox Consumer Products today announced a Collector's Edition and a GameStop-exclusive pre-order offer for its highly anticipated blockbuster Aliens: Colonial Marines™ video game, launching February 12, 2013 worldwide. Offering players a multitude of unique and exclusive content from the ALIENS universe, including four playable characters from the original 1986 movie for competitive multiplayer, the Collector's Edition and the GameStop exclusive are available for pre-order today.
To preorder Aliens: Colonial Marines from GameStop with the exclusive pre-order bonus or the Collector's Edition, please visit http://www.gamestop.com/browse?nav=16k-Aliens+Colonial+Marines.
For more information, please visit www.sega.com/alienscolonialmarines and for press assets please go to www.sega-press.com.
For more news, follow SEGA on Twitter @SEGA, Gearbox Software on Twitter @GearboxSoftware or like us on Facebook www.facebook.com/aliensgames.


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Tattersalls Mare Purchases
By Holly RossDecember 8, 2014General
First Tattersalls purchase Monsun mare Extravaganza (Above)
Belmont Bloodstock is very happy to have made three quality purchases at the recent Tattersalls December Broodmare Sale.
The first purchase (Pictured above) Lot 1478 Extravaganza was consigned by Ronald Rauscher as agent and bought for 70,000 Guineas for Martin Byrne of Wexford Farm and Fergus Doyle who is a fortunate part owner in this year's Melbourne Cup winner Protectionist. The lightly raced mare is a full sister to Group 3 winner Energiser and is out of the winning Theatrical mare Erythesis (USA)
She is by the German super sire Monsun one of Europes best sires that sadly passed away in 2012. Monsun crowned champion German sire four times is the sire of 108 stakewinners and whilst at stud was one of Europe's most expensive sires.
His standout progeny include;
MANDURO; a 4 time Group 1 winner in France and England, ranked #1 in the World Thoroughbred Racehorse Rankings for 2007.
SHIROCCO; 2005 German Horse of the Year and winner of the Deutsches Derby and Breeders' Cup Turf.
STACELITA; 5 time Group 1 winner in France and USA.
SCHIAPARELLI; 4 time Group 1 winner
NOVELLIST; Group 1 winner in France, England and Germany.
ESTIMATE; Ascot Gold Cup winner
Monsun is also the sire of the past two winners of Australia's greatest race the VRC Melbourne Cup this year with his son Protectionist and with last year's favourite Fiorente.
With his pedigree free of Northern Dancer his German bloodlines are in high demand all around the world and will be welcomed in the Australian market. Belmont bloodstock is thrilled to secure this daughter of his for Martin and Fergus, and will follow her future with great interest.
Cape Cross filly Fialka heading down under to Woodside Park (Above)
The second purchase was Lot 1697 a bay filly named Fialka (2011) who was purchased for 110,000 Guineas from the draft of Hesmonds Stud, on behalf of Mark Rowsthorn's Australian Stud Farm Woodside Park. The filly is out of the stakes winning mare First whose wins included the Prix Ceres, Maisons-Laffitte (Listed) in France.
Fialka is a half-sister to three stakes winners including Au Revoir (Sinspiel) a Listed winner in France and emerging stayer, whose recent Australian campaign for French trainer Andre Fabre saw him run well in the Melbourne Cup and go on to win the Group 2 WFA Zipping Classic at Sandown. Fialka is also a half to stakes winner and Group 3 placed Perfect Stride (Oasis Dream) and stakes winner Law Lord (Diktat)
Fialka is by Darley stallion Cape Cross the sire of an impressive 21 individual Group 1 winners, including international superstars Sea The Stars (7 time Group 1 winner, 1st World Thoroughbred Rankings and European Horse of the Year in 2009) ) and Ouja Board (7 time Group 1 winner, European Horse of the Year in 2004 and 2006). Cape Cross is also the sire of New Zealand Champion Seachange and New Zealand bred Able One dual winner of the Group 1 Hong Kong Champions Mile.
This filly will head down under to Woodside Park in Australia to be bred from next season.
Dutch Art filly, a full sister to stakes winner Dutch Connection (Above)
The third purchase was a winning, stakes placed Dutch Art filly named Dutch Romance from the draft of Kitinan Castle Stud. She was purchased for 85,000 Guineas for Woodside Park Stud.
She is out of the Dubai Destination mare Endless Love and is a full sister to impressive two year old stakes winner Dutch Connection, who won the Group 3 Tattersalls Acomb Stakes at York in juvenile course record time and placed 3rd in the Group 1 Goffs Vincent O'Brien National Stakes at The Curragh.
She is by Dutch Art who is the sire of arguably Europes current best sprinter Slade Power winner of 10 races including the Group 1 July Cup and The Group 1 Diamond Jubilee at Royal Ascot in 2014. Slade Power is set to run in the Hong Kong Sprint in mid December and will retire to Darley Stud at the end of his racing career. Dutch Art's other notable progeny include Group 1 winner Garswood and Group 2 winners Caspar-Netscher and Producer.
This filly will also head back to Woodside Park in Australia for the next breeding season.
At a very competitive sale that included Irish 1000 Guineas winner Just The Judge selling for 4.5 million Guineas (AU $8.5 million), the highest price paid for a thoroughbred at public auction anywhere in the world in 2014, Belmont Bloodstock is very pleased to have secured these European purchases for the Australian market.
Good luck to our clients, connections and all those involved.
It is now on to Deauville, France where we can hopefully secure some more great European bloodlines for Australia.


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June 2016 Air Force Military Aviation Defence Industry News
Fokker and GA to collaborate for Predator B landing gear production
Posted On Friday, 03 June 2016 12:45
General Atomics Aeronautical Systems (GA-ASI) and GKN Aerospace's Fokker business unit, a leading Dutch aircraft systems and components manufacturer, yersterday announced that they will collaborate to produce and support landing gear systems for Predator B/MQ-9 Reaper RPA systems. Fokker is GA-ASI's Dutch in-country partner.
AVIC's Y-20 heavy airlifter to be delivered "very soon" to PLAAF
AVIC's Y-20 strategic airlifter to be delivered "very soon" to PLAAF
According to China Daily, the domestically developed Y-20 heavy-lifting transport plane will soon be delivered to buyers, a project manager said on Thursday. The manager expects that China will need at least 1,000 of the huge aircraft. "I can't tell you the exact time planned for delivery, but ... it will be carried out very soon," Zhu Qian, head of Aviation Industry Corp of China's Large Aircraft Development Office, said at a technology exhibition in Beijing.
Liebherr to supply integrated air management system for Antonov's An-132D aircraft
Liebherr-Aerospace Toulouse SAS, Toulouse (France) will supply its integrated air management system for Antonov's new aircraft, the AN-132D. Representatives from Liebherr-Aerospace and the Ukrainian aircraft manufacturer signed the contract on June 1, 2016, at ILA Berlin Airshow.
Lockheed's upgraded T-50A trainer aircraft completes first flight
Lockheed Martin successfully completed the initial flight test of its T-50A configured aircraft. The T-50A is the company's aircraft offering in the U.S. Air Force's Advanced Pilot Training competition. "The aircraft in its new configuration with the 5th Gen cockpit and other upgrades performed flawlessly," said Mark Ward, Lockheed Martin T-50A lead test pilot, after his flight in Sacheon, South Korea.
Kazakhstan to receive first batch of Mi-35M helicopters by 2016-end
The first deliveries of Russia's combat helicopters Mil Mi-35M (NATO reporting name: Hind-E) to Kazakhstan are scheduled for the end of the current year, Alexander Shcherbinin, deputy chief executive for business development at Russian Helicopters holding, the helicopter manufacturer, said on Wednesday.
L-3 wins $1.9bn contract for KC-10 tanker logistic support
The US-based defense contractor L-3 Communications has been awarded a $1.91 billion contract to provide airframe contractor logistics support for USAF KC/KDC-10 tanker aircraft, the US Department of Defense announced on June 1st, 2016.
Rafael's RecceLite pod to be integrated on Italian Air Force Predator B
General Atomics Aeronautical Systems, Inc. (GA-ASI), a leading manufacturer of Remotely Piloted Aircraft (RPA) systems, tactical reconnaissance radars, and electro-optic and related mission system solutions, today announced that it will integrate RecceLite, a versatile imagery reconnaissance pod, onto an Italian Air Force (ItAF) Predator B/MQ-9.
Northrop Grumman's LCR-100N hybrid navigation unit to be offered on King Air turborprops
Northrop Grumman Corporation's flight-critical inertial instruments will soon be offered on Beechcraft King Air turboprops. Northrop Grumman's LCR-100N hybrid navigation unit has been chosen by Beechcraft, a subsidiary of Textron Inc. company, as an inertial product option on the popular King Air turboprop platform.
Israel to get three US-funded C-130J Super Hercules airlifters in 2016
Israel is set to receive three new C-130J Super Hercules military transport aircraft by the end of this year as part of its military aid package from the United States, the Israeli daily Ha'aretz reported Tuesday. Known as the 'Samson' in Hebrew, the three Super Hercules will supplement three others the Israeli Defense Forces currently have as part of its fleet at the Nevatim airbase in the south of Israel.
Airbus Helicopters completes Clean Sky 2-demonstrator pre-design phase
Posted On Wednesday, 01 June 2016 11:06
Airbus Helicopters earlier this year passed an important milestone in the development of the high-speed, compound helicopter demonstrator currently being built as part of the Clean Sky 2 European research programme, the helicopters manufacturer said on June 1st, 2016.
China says J-20 stealth fighter will be deployed "in the near future"
China is still testing its first stealth fighter, the J-20 , but the warplane will soon enter service, the air force said, after pictures circulated in Chinese media suggesting it had already joined the active fleet. "The PLA Air Force refuted the rumor that the J-20 fighter has been deployed to troops on May 31," the PLAAF said today in a statement.
Boeing wins a $3.2 bn USAF contract for JDAM tail kits
The US-based defense giant Boeing has been awarded a $3.2 billion US Air Force contract for Joint Direct Attack Munitions tail kits (JDAM), the US DoD stated on Tuesday May 31, 2016. The JDAM is a guidance kit that converts unguided bombs into all-weather "smart" munitions.


"SHAZAM!" has called down the thunder.
Recall back from the Road Runner cartoons and "The Flash" series, Warner Bros. and DC Comics has released their seventh feature film from the DC Extended Universe. Marking his first superhero film, director David F. Sandberg step up in his game to helm this exciting superhero spin-off from the 2017's "Justice League." He was widely known for directing "Annabelle: Creation" which is part of "The Conjuring Universe" franchise. "Shazam!" stars Zachery Levi ("Chuck," "Tangled") as the titular role as a teenager-turned-superhero Billy Batson who harnesses magical powers bestowed on him by an ancient wizard.
In this latest entry of the DC Universe, Billy Batson (portrayed by Asher Angel and Zachary Levi (in a superhero form)) is set to move into his new family's home with the other five foster kids. When he finds himself transported into an ancient world where the ancient wizard transforms him into an adult with superheroes, he must learn to use them responsibly in order to prevent the obsessive Dr. Thaddeus Sivana (portrayed by Mark Strong) from taking his powers away and commit villainous crimes in the city.
Zachary Levi plays as the superhero version of Billy. He does a fabulous job on his role of Chuck from the show "Chuck" and Flynn Rider from Disney's animated film "Tangled," Levi does a great job with the role, nailing both the physicality and humor. Sure, he can be immature and childish at all times, but Levi plays it perfectly. With the CGI and special effects the filmmakers being used for his Shazam role, the filmmakers done a perfect job on giving the looks and personality for Levi. Not to mention the Mark Strong on his villainous Dr. Thaddeus Sivana character, he really fit the bit on playing the role as a villain that was reference from the "James Bond" films and "Indiana Jones" films.
Based on the creation of DC's Captain Marvel (not to be confused with the Marvel film starring Brie Larson) and the 1941 black-and-white film "Adventures of Captain Marvel," "Shazam!" provides a unique storytelling with a big boom, degree of excitement or fanfare of any kind. It delivers a stunning turn of events that became a nod to the "Superman" films including the classics and the DCEU films. Even the movie style and the Shazam character matches the resemblance from the "The Flash" television series. Let's not forget about the action which is vibrant and so are the producers and editors who always make it easy to tell what is happening in the scene.
However, the first ten-to-fifteen minutes of the film got me off-course and confusing because the setting of the ancient world doesn't have any clues or unexplainable knowledge to see why or how it happens. I didn't really enjoy parts of Mark Strong's performance as he seems to be too cheesy to digest the action and scenes centering on him.
Aside from Zachary Levi himself, I heavily enjoyed the children cast, consisting of Jack Dylan Grazer (2017's "IT"), Grace Fulton, Ian Chen, Faithe Herman, Jovan Armand. They both done a terrific job on keeping up the paces on the acting and the comedy for a background. The children cast also plays the role for the story's dynamics.
Also returning from another film that was part of the DC Extended Universe is Djimon Hounsou who played as Fisherman King in 2018's "Aquaman." He provides some sort of a dark, deeper, and serious tones for his character just like he did when he encountered Arthur Curry/Aquaman.
Despite being a superhero film, "Shazam!" is a story about a kid who is desperate of searching for his old family to be back together, but must learn to accept the new, unexpected family no matter what.
When it comes down to it, "Shazam!" is a great time at the theater. The sounds of people's laughter just grew louder and louder after the cast delivers the punchlines and the funny dialogue. It is fun, hilarious movie with heartfelt moments for kids and teenagers. It would been a tough decision to decide which movie to watch for your own amusement. I really wanted to enjoy this movie, but the "oohs, "aahs," and "wows" are missing right there. If you want to head over to the movie theater, put up a "proceed with caution" sign.


I am looking for brand enthusiasts! I am offering a 3 month arrangement for 40% off Dylbug mealtime sets. The Brand Enthusiast is required to purchase a minimum of 2 sets (plate + cutter) over the course of 3 months, 1 which must be in the first week so they have something to photograph during the 3 months. This is in exchange for a minimum of 3 quality photos per month on Instagram. Photo ideas include their child/children using their Dylbug sets (eating or dressing them up with food) healthy meals or snacks on their plate(s), flat lays or even Instagram stories of using their sets. All photos and stories need to be tagged with @dylbug_ and #DylbugDressUp.
I couldn't love this any more! It is adorable and wonderful all at the same time! What can I do to help share your great idea?
Hey Arlena, This search is now closed but if you sign up for my newsletter on my homepage you will find out about my next Brand Enthusiast search in a few months. That is a great way to help spread the word about my brand. Thanks!


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If you have a clearly defined scope of work, consider this traditional construction approach.
We've been building since 1896, and Shockey's proven track record in general contracting reflects our commitment to our clients. Our seasoned team is proactive in identifying potential issues and bringing solutions to the table that will actually work in the field.
We excel at matching the best people to your project, and the Shockey experts have experience in just about every type of commercial construction. We have craftsmen with extensive experience in traditional construction techniques, and green building specialists skilled in the latest sustainability practices. Shockey provides solid, hands-on experience in planning and execution of projects — big and small.
In 2019, General Contractors Magazine listed Shockey among the Best School Contractors in the United States.
I was very impressed with the on-site team during a recent renovation project at our facility in Winchester. I appreciated the care and understanding that they displayed as they worked around our residents and staff — and the quality of workmanship." — Scott Burkholder, Regional Director of Asset Management, Inspirit Senior Living
"Howard Shockey & Sons is the best contractor Wakefield has ever known." — Peter A. Quinn, Headmaster, Wakefield School
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LCPS: Tuscarora High School
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HomeTea Party Billboard in Iowa Depicts Obama alongside Hitler and Lenin.
Tea Party Billboard in Iowa Depicts Obama alongside Hitler and Lenin.
Nobody July 14, 2010
UPI is reporting that in Mason City, Iowa, a local Tea Party group put up a billboard with a picture of Barack Obama, Adolph Hitler, and Vladimir Lennon.
The billboard which was bought by the North Iowa Tea Party, was quickly covered up by the group.
One Iowa Tea Party member said the billboard crossed a dangerous line. "At our last rally we saw some people with these kinds of signs and asked people to put them down," John White, coordinator of the Iowa Tea Party movement said. "It's borderline hate crime." Members of the North Iowa Tea Party either declined to speak or did not return calls to Television and Newspaper outlets on Monday. The group officially apologized for their billboard on Wednesday. UPI is reporting that in Mason City, Iowa, a local Tea Party group put up a billboard with a picture of Barack Obama, Adolph Hitler, and Vladimir Lennon.
The North Iowa Tea Party's Co-Chairman Bob Johnson commented. "The image of Hitler just totally wiped everything else and it misrepresents the Tea Party movement," "They were right from the standpoint that the image was not a positive reflection on the tea people." One group was quite relieved that the billboard was taken down the American Gathering of Holocaust Survivors and their Descendants. They told the New York Daily News
The Tea Party chapter "acted properly in removing the grotesquely offensive sign which should never have been put up in the first place," the group said in a statement. "We ask that political groups do not trivialize our suffering in the future by making false analogies with Hitler's horrendous crimes."
I will be more than happy to give them that message once the millions of Americans, British, Polish, German, Russian, etc that lost their lives during WWII come back from the dead and are removed from the roster of those that lost their lives at the hands of an evil dictator. Yes, Hitler did target Jews, but most of the free world suffered at the hands of this lunatic, and as an American whose relatives fought and died in that war, it is my duty to inform you that we all have the right to be mad at Hitler, and use his ugly face as a tool to show people what evil really looks like. I am deeply sorry for your pain, but the analogy is valid, so your banal statement makes you look like you are really saying it because you vote Democrat, and not because you were really upset about the billboard.
I would like to be the first to say " I love you North Iowa Tea Party!" This is an amazingly fun sign. The stark reality of it all is this...statements made by Barack Obama closely parallel statements made by these two madmen, and we all know how there stories turned out. Barack Obama is for all intents and purposes the Democrats "golden negro". He has almost no political experience, his decisions on policy, and foreign relations so far have been disastrous, and the general public is starting to wake up and turn against this once shining lieght of hope. It has become painfully clear that this man was elected based solely on the color of his skin, and not on his merits. The most painful truth is the fact that it was black Americans that help elect him. He is the greatest triumph of the Democratic party. The first black president. The only problem with their great messiah is that he is an utter failure.
Is this billboard going to far? No. Is it controversial? Yes. Do I give a rats ass? Not one bit. It was all the rage when Bush was in office to wear shirts that said "Not My President." with a picture of Bush below the catch phrase. I need one of those T-shirts now for this man. Has he committed genocide against the jews? Not yet. Killed 20 million dissenters? Not that I can see. The point of this billboard, which is also my point, is that the path this man has taken, is the same path that led to Auschwitz, and the Tyranny under Stalin that led to the mass graves in Bykivnia, Kurapaty, Butovo, Sandarmokh, Kiev, Uman', Bila Tserkva, Cherkasy and Zhytomyr. People are starting to realize the truth and are taking a stand against it.
The protest groups, and the Tea Party in particular, are made up of "Awake" Americans. Those who have shaken off the fog of complacency and are ready to do battle with the most corrupt government in our nations great history. Most of what we are seeing in Washington today is not blatant. It is very subtle, but no less dangerous. The expansion of the government though far-reaching, and expensive new government programs, new 'Czars' to help micromanage every aspect of the lives of Americans, and especially businesses, big and small. In Germany in the months preceding World War II, the subtle language of the Nazi party became a firestorm of pure evil. It didn't take long for the Nazi's to take the unassuming changes they had enacted and turn them in to weapons of total domination. The same thing could happen here in America.
My greatest hope is that in November, the stranglehold the Democrats have on this country will be broken as they lose their majority in the House and possibly the Senate as well. It will be through the hard work of the Teat Party protesters and other groups like them such as the 9/12 movement ,Americans for Prosperity, Americans for Tax Reform, FreedomWorks and Citizens United that will help turn the tide. Despite what the Democrats, the NAACP, and other liberal groups might claim, these groups are made up of real Americans organizing to help shape the political landscape. All the rhetoric, slander, and nonsensical accusations in the world will not derail this train. This train is being conducted by true patriots, and they will not be derailed by the hate filled lies of the liberal zombies who feel threatened by a populace they can no longer manipulate and control.
I do not have a problem with the billboard. It's call Freedom of Speech, but the mainstream media will make a big deal out of it although Pelosi can call us "anti-American" just for disagreeing with her.
Enough of federal tyranny & the rantings of both political parties. I can only recommend you just read that new book about a small town of Americans who stand up to high taxes, contintual foreign wars & bureaucrats crossing the land to harass the people. It's a great read cause it could be our home town one day & us taking a stand.
www.booksbyoliver.com
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Crypto Market Rebounds. Investors Hold Steady. Consumer Interest Wanes.
The Pros And Cons Of Natural Gas Drilling In Pennsylvania and Central New York


Parking at HFC is free; students and visitors do not need parking passes.
However, employees must obtain a parking permit from the Office of Campus Safety to gain access to the gated employee parking lots. The circle drive entrance (Flag Pole) is for handicap pickup or drop-off, and short-term visitor parking only. All other pickups or drop-offs are to be made in student lots.
Both state law and local ordinance authorize enforcement of parking regulations on campus with the same authority as public roadways. Accordingly, vehicles are only allowed to park in areas designated as parking spaces. Vehicles may not park on the grass, sidewalks, along curbs, in yellow hash marked areas, or in any other area not marked or designated as a parking space. Vehicles are not allowed on campus past 11 PM without authorization from the Office of Campus Safety.
Campus Safety personnel have the authority to issue Uniform Law Citations to parking violators. Vehicles parked contrary to regulations will be ticketed and may be towed at the owner's expense.
If you receive a ticket, do not ignore it! Parking ticket fees must be paid to the City of Dearborn, and will be subject to late fees and escalating penalties, up to and including impounding your vehicle, like all other local parking tickets.
Uniform Law Citations may be paid or contested through the 19th District Court in Dearborn. Fines and procedures including the address and phone number of the court are located on the back of the ticket.
As an alternative to Uniform Law Citations, at the discretion of Campus Safety, an orange warning sticker may be put on the offender's vehicle window. This is done for first-time offenders in minor offenses only, such as taking up two parking spots or unauthorized parking in a staff lot. (By contrast, parking in a handicap spot or a fire lane is a major violation and will always receive a ticket or you will be towed).
The orange sticker is a warning that your vehicle is parked illegally and is subject to ticketing and impoundment. No action is required except to move the vehicle before it is issued a ticket or is towed. Chronic offenders will receive a Uniform Law Citation (ticket) and will be towed at the owner's expense.


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Кристоф Доминиси (; 20. мај 1972 — 24. новембар 2020) био је професионални француски рагбиста.

Биографија
Висок 172цм, тежак 83кг Доминиси је показао као дечак велики таленат за фудбал, али ипак се определио за игру са јајастом лоптом која је настала од фудбала - рагби. Доминиси је у каријери наступао за Ла Валете, Рагби клуб Тулон и Стад Франс. За француску рагби јунион репрезентацију Кристоф је одиграо 65 тест мечева и постигао 25 есеја. Играо је за Француску на три светска првенста, укључујући и финале светског првенства у рагбију 1999. које су галски петлови изгубили од Аустралије.

Извори

Рођени 1972.
Умрли 2020.
Француски рагбисти


The New York Daily News reports that Columbia Presbyterian Hospital in New York has discovered a number of patients have died from Legionnaire's bacteria. An investigation by state health inspectors is underway.
Victor Yu, a Pittsburgh doctor and one of the nation's top experts on Legionnaires', said Columbia Presbyterian brought him to New York in January to advise the hospital on how to keep the bacteria out of its water.
"I believe they had some intermittent cases, all of whom - or most of whom - survived," he said. "I'm going to guess that even though they had everything in place, something slipped through, and I would say that's almost impossible to stop."
Legionnaires' bacteria [Legionella pneumophila] are commonly found in water pipes and are not usually harmful. But in a hospital setting they can attack elderly patients or those with compromised immune systems, giving patients a form of pneumonia.
Experts say Legionnaires' is almost certainly underreported in hospitals, which can often find the bacteria or the infection if they look hard enough.


text:
Blood and bone marrow cancers
Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia
Technology appraisal guidance [TA193] Published date: 28 July 2010
3 The manufacturer's submission
4 Consideration of the evidence
6 Recommendations for further research
7 Related NICE guidance
8 Review of guidance
Appendix A: Appraisal Committee members and NICE project team
Appendix B: Sources of evidence considered by the Committee
Changes after publication
4.1 The Appraisal Committee reviewed the data available on the clinical and cost effectiveness of rituximab, having considered evidence on the nature of relapsed or refractory chronic lymphocytic leukaemia and the value placed on the benefits of rituximab by people with the condition, those who represent them, and clinical specialists. It also took into account the effective use of NHS resources.
4.2 The Appraisal Committee discussed current standard clinical management of relapsed or refractory chronic lymphocytic leukaemia. The Committee heard from clinical specialists that the most frequently used first-line treatments are: fludarabine plus cyclophosphamide with or without rituximab; and chlorambucil for people unable to have fludarabine because they have a poor performance status. However, for relapsed or refractory chronic lymphocytic leukaemia there is no single standard treatment option. The choice of treatment depends on a number of factors, including the presence of genetic abnormalities such as del(17p) mutation, previous treatments the person has received, whether a response was achieved from previous treatments, and if so, the duration of response. Clinical specialists noted that for these reasons, they considered it important to have a range of treatment options available. The Committee heard that, for relapsed disease, treatments used previously may be administered again either with or without the addition of another therapeutic agent, or alternatively a different agent may be used. When additional or different treatments were used, these could include fludarabine and cyclophosphamide with the addition of mitoxantrone, alemtuzumab and stem cell transplantation.
4.3 The Committee noted that the clinical effectiveness evidence for this appraisal was based mainly on a single unpublished randomised controlled trial (the REACH trial). In this trial rituximab plus fludarabine and cyclophosphamide was compared with fludarabine and cyclophosphamide. The Committee heard from clinical specialists that people in the REACH trial were younger and had a better performance status than people with chronic lymphocytic leukaemia seen in routine practice in the NHS in England and Wales. However, the clinical specialists commented that the people in the trial were representative of the people who would be eligible for treatment with fludarabine plus cyclophosphamide. The Committee discussed the inclusion in the trial of people who had Binet stage A chronic lymphocytic leukaemia. It heard from clinical specialists that the decision to treat chronic lymphocytic leukaemia would depend on symptoms and progression of disease rather than specific staging.
4.4 The Committee discussed the exclusion from the REACH trial of people who were previously treated with fludarabine combination therapy, people who were previously treated with rituximab and people who had chronic lymphocytic leukaemia that was refractory to fludarabine. However, it heard from clinical specialists that, if suitable, people often had fludarabine combination regimens as a first-line treatment. It also heard that the publication of 'Rituximab for the first-line treatment of chronic lymphocytic leukaemia' (NICE technology appraisal guidance 174) recommending rituximab plus fludarabine and cyclophosphamide meant that in the future an increasing number of people with relapsed or refractory disease will have had rituximab and fludarabine combination therapy as a first-line treatment. The Committee considered the exclusion of these groups from the clinical trial was a limitation for decision making because it meant that the trial population did not reflect all the people with relapsed or refractory disease who would be eligible for rituximab plus fludarabine and cyclophosphamide in the NHS.
4.5 The Committee accepted that the REACH trial demonstrated that the addition of rituximab to fludarabine and cyclophosphamide improved progression-free survival and complete response rates. The Committee noted there was potential for bias in outcome assessment because of the open-label design of the trial. The Committee discussed the results of an interim analysis of the trial data. This was an independent assessment of response that was provided as academic-in-confidence. The Committee noted that there was a difference between the investigator and independent assessments but was aware that the interim analysis was conducted 1 year before the investigator assessment. The Committee heard from clinical specialists that assessment of progression-free survival was subjective and could change depending on familiarity with assessment tools. The Committee considered that the differences in these assessments led to uncertainty in estimating the additional benefit of rituximab.
4.6 The Committee noted that in the REACH trial median overall survival had not been reached in the rituximab group, and that survival curves for patients in the two treatment groups hardly diverged until 30 months. The Committee heard from clinical specialists and patient experts that it is difficult for studies of chronic lymphocytic leukaemia to demonstrate an effect of treatment on overall survival because of the long natural history of the disease and because people with the disease often receive multiple treatments. It also heard that progression-free survival and response rates were often accepted as surrogates for overall survival. Furthermore, clinical specialists commented that longer term trial evidence is emerging that demonstrates an overall survival benefit of first-line treatment with rituximab plus fludarabine and cyclophosphamide. On balance, the Committee was persuaded that the improvements observed in progression-free survival and response rates were likely to lead to at least some gain in overall survival, although this gain could not be quantified.
4.7 The Committee noted that in the REACH trial there were slightly more grade 3 or 4 adverse events and treatment-related deaths in the rituximab plus fludarabine and cyclophosphamide group than in the fludarabine and cyclophosphamide group. It heard from clinical specialists that people with chronic lymphocytic leukaemia are aware of the risks of treatments and are willing to accept these risks because of the severity of the condition. The Committee discussed the six cases of hepatitis B seen in the trial in the rituximab plus fludarabine and cyclophosphamide group. However, it heard from clinical specialists that this would be unlikely to happen in the UK because all people with chronic lymphocytic leukaemia are screened for hepatitis B before treatment, and so hepatitis B reactivation would be rare.
People who have previously received treatment with rituximab
4.8 The Committee discussed the use of rituximab plus fludarabine and cyclophosphamide in people who have previously received treatment with rituximab-containing regimens. These people were excluded from the REACH trial, and the Committee heard from clinical specialists that there was uncertainty about the degree of benefit of retreatment with rituximab. However, patient experts indicated that there was anecdotal evidence that people retreated with rituximab may have a good response to treatment. The Committee also noted comments received at consultation that retreatment with rituximab is common in other lymphoproliferative conditions where there has been a good response, and that the same could be expected for chronic lymphocytic leukaemia. It was also aware that over the next few years there would be an increasing number of people who would be treated with rituximab and who would require further treatment following relapse.
4.9 The Committee considered the evidence from uncontrolled phase II studies reporting the benefits of retreatment with rituximab and noted the methodological limitations of these studies. It discussed the MDACC data provided during consultation, reporting that there was a similar response rate and progression-free survival in people who have previously received rituximab compared with people who have not. However, it noted this study had limitations in its design, for example, it was open label and uncontrolled (and therefore not randomised). The study included 100 people who had previously been treated with a rituximab-containing regimen. However, limited data were provided about these regimens and they included rituximab monotherapy and rituximab plus chemotherapy other than fludarabine and cyclophosphamide. The Committee was not persuaded that the results from this study could be considered reflective of the UK population, of whom an increasing number will have previously received rituximab plus fludarabine and cyclophosphamide.
People who have previously received treatment with fludarabine
4.10 The Committee considered the use of rituximab plus fludarabine and cyclophosphamide in people who have previously received treatment with fludarabine. It first discussed people who had previously had a response to treatment with fludarabine (that is, people with fludarabine-sensitive disease). The Committee discussed evidence from the REACH trial which included people whose disease was sensitive to fludarabine monotherapy. It noted that the REACH trial did not include people who had previously received fludarabine combination therapy. However, the Committee considered that the clinical effectiveness was likely to be similar for people who were sensitive to fludarabine monotherapy and for people who were sensitive to fludarabine combination therapy. Therefore the Committee was persuaded that data from the REACH trial could apply to people who were sensitive to fludarabine combination therapy.
4.11 The Committee then discussed the evidence for the use of rituximab plus fludarabine and cyclophosphamide in people who have chronic lymphocytic leukaemia that is refractory to fludarabine. It noted the methodological limitations of the non-comparative studies provided by the manufacturer. The Committee understood that clinical specialists did not consider that people with fludarabine-refractory disease should be retreated with the same fludarabine-containing regimen. The Committee considered that the results of the MDACC study indicated a lower response to treatment with rituximab plus fludarabine and cyclophosphamide in chronic lymphocytic leukaemia refractory to fludarabine than in disease that was sensitive to fludarabine. The Committee concluded that although people with fludarabine-refractory disease may derive some benefit from retreatment with fludarabine-containing chemotherapy regimens such as rituximab plus fludarabine and cyclophosphamide, the benefit was likely to be less than if the disease was fludarabine sensitive.
Rituximab plus chemotherapy regimens other than fludarabine plus cyclophosphamide
4.12 The Committee recognised that the marketing authorisation for rituximab allowed its use with any chemotherapy regimen. It discussed the evidence on rituximab plus chemotherapy regimens other than fludarabine and cyclophosphamide. The Committee discussed comments received on the appraisal consultation document that suggested that people who cannot take fludarabine and people with chronic lymphocytic leukaemia that is refractory to fludarabine may benefit from treatment with rituximab plus other chemotherapy. The Committee was aware of the lack of treatment options available to these people. However, the Committee noted the methodological limitations of the non-comparative evidence provided. It heard from the manufacturer that a study of rituximab plus chlorambucil for first-line treatment was under way and that preliminary data from a cross-trial analysis indicated that response rates were better for people treated with rituximab plus chlorambucil than with chlorambucil alone. Overall, the Committee considered that there was significant uncertainty about the relative benefit of adding rituximab to chemotherapy regimens other than fludarabine and cyclophosphamide and therefore more research was needed.
4.13 The Committee reviewed the economic model submitted by the manufacturer and the ERG's analysis of the model. It was aware that the model did not allow transition from the progressed health state to the progression-free survival heath state. The Committee considered that this did not appropriately reflect the disease process because people may receive later treatments with further periods of progression-free survival. The Committee was aware that a similar model had been used in the appraisal of 'Rituximab for the first-line treatment of chronic lymphocytic leukaemia' (NICE technology appraisal guidance 174). On balance, the Committee agreed that the model could be used as a basis for considering the cost effectiveness of rituximab.
4.14 The Committee considered how the costs of rituximab had been incorporated into the economic model. It noted that the ERG considered the assumption that costs were spread throughout the cycle in the base-case analysis inappropriate because rituximab was provided on the first day of each cycle. Therefore, the ERG explored remodelling rituximab costs so that costs were incurred at the start of each treatment cycle. The ERG re-analysis was corrected after consultation on the appraisal consultation document, and concluded that the ICER increased from £15,600 per QALY gained in the base case to £16,600 per QALY gained, which the Committee accepted.
4.15 The Committee discussed the utilities used in the economic model and noted that the evidence base for these estimates did not reflect the NICE reference case; in particular, preference-based methods were not used. It was aware that a utility study was under way in people with chronic lymphocytic leukaemia in the UK but detailed results from this study for people who had progressed following treatment were not yet available. The Committee heard from patient experts that they considered an assumption of only a small difference in utility between the progressed and progression-free survival health states was not realistic. People greatly value being progression free and asymptomatic – it is associated with a marked improvement in quality of life. The Committee considered the lack of appropriate utility data contributed to uncertainty in the economic model.
4.16 The Committee discussed whether the modelled gains in overall survival from the economic model appropriately reflected the data from the clinical trial. It noted that the outputs from the manufacturer's economic analysis modelled a difference in overall survival between treatment groups from the start of treatment that did not reflect the trial data. The overall survival curves from the clinical trial provided by the manufacturer showed no difference in overall survival between the treatment groups before around 30 months, although, beyond this time, the extrapolated curves began to diverge. The Committee considered that there was little evidence from the REACH trial to support the validity of the analysis provided by the manufacturer and that the manufacturer's base-case analysis was likely to have overestimated the benefits associated with rituximab.
4.17 The Committee considered the estimates of cost effectiveness provided by the manufacturer and the additional exploratory analyses performed by the ERG that examined the impact on the ICER of reducing the survival advantage of treatment with rituximab. It noted that using an assumption of no overall survival advantage had the effect of increasing the cost-effectiveness estimates from £15,600 per QALY gained in the base case to £41,000 per QALY gained. Furthermore it recognised that when there was no modelled gain in overall survival the results became very sensitive to the difference between the utility values used for the progression-free survival health state and those used for the progressed health state which were uncertain. However, based on comments from the clinical specialists, the Committee was persuaded that it was appropriate to assume at least some gain in overall survival in the economic model. Overall, the Committee considered that the most plausible ICER was likely to be at the upper end of the range of £20,000 to £30,000 per QALY gained, which was higher than the ERG's corrected base case of £16,600 per QALY gained.
4.18 On balance, the Committee was persuaded that even taking into account the uncertainty about utility values and the uncertainty about a gain in overall survival from treatment with rituximab, the use of rituximab plus fludarabine and cyclophosphamide was a cost-effective use of NHS resources for the population represented in the REACH trial; that is, people who have not previously received rituximab or fludarabine combination therapy and those whose disease is not refractory to fludarabine monotherapy. Additionally, the Committee was persuaded that the cost effectiveness of rituximab plus fludarabine and cyclophosphamide could be generalised from people whose chronic lymphocytic leukaemia was sensitive to fludarabine monotherapy to those whose disease was sensitive to fludarabine combination therapy (section 4.10).
4.19 The Committee was not persuaded of the clinical effectiveness of rituximab plus fludarabine and cyclophosphamide for people who have already been treated with rituximab. Nevertheless, the Committee discussed the cost-effectiveness estimate provided by the manufacturer during consultation of £22,500 per QALY gained for people who had previously received rituximab. It noted that this did not include the correction for the timing of rituximab costs. It recognised that there was considerable uncertainty in the manufacturer's original base-case ICER because of the uncertainties in the gains in overall survival and the limitations in the health-related quality of life data available. The Committee noted that even for the REACH trial population the most plausible ICER was likely to be at the upper end of the range of £20,000 to £30,000 per QALY gained. It considered that in the rituximab-pretreated population, for which there was little research, the manufacturer's estimated ICER could not provide a basis for decision making. The Committee concluded that rituximab plus fludarabine and cyclophosphamide could not be recommended as an appropriate use of NHS resources for everyone who had previously been treated with rituximab. However, because of the uncertainty about the benefits of retreatment with rituximab, the Committee concluded that rituximab plus fludarabine and cyclophosphamide should be recommended in the context of research for people with relapsed or refractory chronic lymphocytic leukaemia that has previously been treated with rituximab. The Committee was aware of comments from consultees that some people in clinical trials had received rituximab in combination with treatments other than fludarabine and cyclophosphamide and at doses of rituximab lower than the licensed dose. The Committee considered that this technology appraisal guidance should not adversely affect recruitment to future or ongoing clinical trials. Therefore the Committee concluded that rituximab plus fludarabine and cyclophosphamide could be recommended for people with relapsed or refractory chronic lymphocytic leukaemia when rituximab had previously been given in the context of a clinical trial, either at a dose lower than currently licensed for chronic lymphocytic leukaemia, or in combination with chemotherapy other than fludarabine and cyclophosphamide.
4.20 After concluding that rituximab plus fludarabine and cyclophosphamide was cost effective for people with chronic lymphocytic leukaemia that was sensitive to fludarabine (section 4.18), the Committee then considered its use in people with fludarabine-refractory disease. It noted the lower clinical response in people who were refractory to fludarabine than in people who were sensitive to it (section 4.10), and that clinical practice was not to retreat these people with the same fludarabine regimen. It also noted that the manufacturer had not provided an estimate of the cost effectiveness of rituximab plus fludarabine and cyclophosphamide in this population. The Committee heard from the manufacturer that there were difficulties identifying baseline event rate data and that the relative efficacy of rituximab therapy in this group was uncertain. On this basis the Committee considered that the use of rituximab plus fludarabine and cyclophosphamide for the treatment of people who had already had fludarabine could only be considered a cost-effective use of NHS resources when the chronic lymphocytic leukaemia remained fludarabine sensitive and not when it was fludarabine refractory.
Rituximab plus chemotherapy regimens other than fludarabine and cyclophosphamide
4.21 The Committee understood the potential need for other rituximab combinations for people whose disease is refractory to fludarabine or is not suitable for treatment with fludarabine. However, it concluded that there was significant uncertainty about the relative benefit of adding rituximab to chemotherapy regimens other than fludarabine and cyclophosphamide and therefore more research was needed. Furthermore, the Committee noted there was no current basis for estimating the cost effectiveness of such combinations, or for considering them to be cost effective. The Committee was aware that people with chronic lymphocytic leukaemia that is not suitable for treatment with fludarabine plus cyclophosphamide might be treated with rituximab plus other chemotherapy. It was also aware that this group might be older and include people with poor performance status or comorbidities. The Committee considered whether equalities legislation and the requirement for fairness meant that it should make a positive recommendation for rituximab plus other chemotherapy for this group. However, given the lack of evidence for both the clinical and cost effectiveness of this treatment, the Committee concluded that rituximab plus chemotherapy other than fludarabine and cyclophosphamide should only be used for the treatment of relapsed or refractory chronic lymphocytic leukaemia in the context of research.


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text:
package builders.loom.util.serialize;

import java.io.BufferedInputStream;
import java.io.IOException;
import java.nio.ByteBuffer;
import java.nio.channels.SeekableByteChannel;
import java.nio.file.Files;
import java.nio.file.Path;
import java.nio.file.StandardOpenOption;
import java.util.Arrays;
import java.util.List;
import java.util.function.Consumer;
import java.util.function.Function;

@SuppressWarnings("checkstyle:magicnumber")
public final class SimpleSerializer {

    // Loom Simple Serializer
    private static final byte[] MAGIC_HEADER = {'L', 'S', 'S'};
    private static final byte VERSION = 1;
    private static final byte UNCOMMITED = 0;
    private static final byte COMMITED = 1;
    private static final int HEADER_SIZE = MAGIC_HEADER.length + 7;

    private SimpleSerializer() {
    }

    public static <T> void write(final Path file, final Iterable<T> records,
                                 final Function<T, Record> mapper) throws IOException {
        int recordCnt = 0;
        byte recordSize = -1;

        try (final SeekableByteChannel channel = Files.newByteChannel(file,
            StandardOpenOption.CREATE, StandardOpenOption.TRUNCATE_EXISTING,
            StandardOpenOption.WRITE)) {

            final ByteBufferChannelStream bbs = new ByteBufferChannelStream(channel);

            // write header
            bbs.put(buildHeader(recordCnt, recordSize, UNCOMMITED));

            for (final T record : records) {
                final List<String> fields = mapper.apply(record).getFields();
                if (recordSize < 0) {
                    if (fields.size() > Byte.MAX_VALUE) {
                        throw new IllegalStateException("Max " + Byte.MAX_VALUE + " fields per "
                            + "record allowed");
                    }
                    recordSize = (byte) fields.size();
                } else if (recordSize != fields.size()) {
                    throw new IllegalStateException("Every record must have the same field "
                        + "count. First record had " + recordSize + " fields, now got "
                        + fields.size() + " fields");
                }

                for (final String field : fields) {
                    if (field != null) {
                        bbs.putInt(field.length());
                        bbs.put(field);
                    } else {
                        bbs.putInt(-1);
                    }
                }

                recordCnt++;
            }

            bbs.flush();
            commit(channel, recordCnt, recordSize);
        }
    }

    private static ByteBuffer buildHeader(final int recordCnt, final byte recordSize,
                                          final byte committed) {

        return ByteBuffer.allocate(HEADER_SIZE)
            .put(MAGIC_HEADER)
            .put(VERSION)
            .putInt(recordCnt)
            .put(recordSize)
            .put(committed)
            .flip();
    }

    // write record count/size and commit status
    private static void commit(final SeekableByteChannel channel,
                               final int recordCnt, final byte recordSize) throws IOException {

        final ByteBuffer buf = buildHeader(recordCnt, recordSize, COMMITED);
        channel.position(0);
        do {
            channel.write(buf);
        } while (buf.hasRemaining());
    }

    public static void read(final Path file, final Consumer<Record> consumer)
        throws IOException {

        try (final EnhancedBufferedInputStream in = new EnhancedBufferedInputStream(
            new BufferedInputStream(Files.newInputStream(file, StandardOpenOption.READ)))) {

            validateMagic(in.read(MAGIC_HEADER.length));
            validateVersion(in.readByte());
            final int recordCnt = in.readInt();
            final byte recordSize = in.readByte();
            validateCommitted(in.readByte());

            for (int r = 0; r < recordCnt; r++) {
                final String[] fields = new String[recordSize];
                for (int i = 0; i < recordSize; i++) {
                    final int fieldLength = in.readInt();
                    fields[i] = fieldLength < 0 ? null : in.readString(fieldLength);
                }
                consumer.accept(new Record(fields));
            }

        }

    }

    private static void validateMagic(final byte[] magic) throws IOException {
        if (!Arrays.equals(magic, MAGIC_HEADER)) {
            throw new IOException("Invalid magic header");
        }
    }

    private static void validateVersion(final byte version) throws IOException {
        if (version != VERSION) {
            throw new IOException("Invalid version " + version);
        }
    }

    private static void validateCommitted(final byte committed) throws IOException {
        if (committed != COMMITED) {
            throw new IOException("Uncommitted file");
        }
    }

}

redpajama_set_name: RedPajamaGithub


This entry was posted in Quick! and tagged 29er, Brighton, Friends, light, Shorts, Stanmer Park, Summer. Bookmark the permalink.
What alien planet was that photo taken on?
Stanmer in summer. How things change!
Looks like summer to me. Its camp and mild here in the Alps. Fingers crossed for sun or snow, so I can decide between my bike or skis!
That was most certainly summer at the delightful Stanmer park. Can't wait for those days to return.


text:
Bowman's 2021 success aiding Best Friends to 'Save Them All'
48 July 22, 2021
By Jaret Arneson
CONCORD, N.C. – Once Alex Bowman was tabbed to driver the No. 48 Chevrolet Camaro ZL1 1LE toward the end of last season, he worked with primary sponsor Ally to bring together two of his passions: helping animals and racing.
Together, they partnered with Best Friends Animal Society to give back to each city where a race will be held on the 2021 schedule by donated to an animal shelter in that community.
"Best Friends is a really cool organization, and their goals are amazing," Bowman said. "Obviously, I am a big dog guy, so to be able to help some animals find homes is really special and trying to end kill shelters by 2025 is a great goal."
Bowman debuted the purple and orange Best Friends paint scheme on his No. 48 Chevrolet Camaro at Phoenix Raceway on March 14. Bowman and Ally agreed to help shelters that were close to the racetracks on the Cup schedule with two combined donations.
"The first thing that Ally did when we teamed up to start the year was ask me what I cared about and things that I wanted to do," Bowman said. "We teamed up with Best Friends and we have been able to pick a shelter at every track and donate $1,000 from Ally and $1,000 from myself to that shelter and, if we win, the donation goes up to $10,000.
"I have been able to give three shelters so far $10,000 and, hopefully, we can increase that number a little bit. Best Friends is a really cool organization and their goals are amazing."
To date, Bowman and Ally have donated a combined $66,000 for 19 different shelters across the country. After Bowman's three wins at Richmond Raceway, Dover International Speedway and Pocono Raceway, Ally gave the additional $10,000 to Richmond SPCA in Virginia, Brandywine Valley SPCA in Delaware and Animal Food Bank of Lehigh Valley in Pennsylvania.
"(I'm) just glad to have a partner like Ally that is passionate about things that are real to me and that I can enjoy being a part of," Bowman said. "It's been a lot of fun; I have been able to go to a couple of shelters this year and it's been great to get to spend some time with some animals."
After the two-week break from racing, Bowman will have 14 more races to help support his furry friends. The 28-year-old driver heads to Watkins Glen on Sunday, Aug. 8 to race for another win in the 2021 NASCAR Cup Series season and support his best friends.