text:
The crank medical organization to which HHS nominee Dr. Tom Price belongs lays down a heaping helping of antivaccine pseudoscience
By oracknows on December 21, 2016.
Three weeks ago, I wrote a post that, much to my surprise, went viral, garnering more Facebook "Likes" than any before it, although it only came in maybe third in traffic after the all-time record-holding post from a couple of years ago. Maybe I shouldn't have been surprised. It was, after all, about Tom Price, Donald Trump's nominee for Secretary of the Department of Health and Human Services (HHS). What I noted that apparently caught the attention of many times more people than my usual daily brain droppings usually do was that Tom Price belongs to one of the wingnuttiest of wingnut medical groups I've ever encountered, the Association of American Physicians and Surgeons (AAPS). There's no need for me here to reiterate the group's Ayn Rand-like worship of the brave maverick doctor über alles in detail, as I've done that before multiple times beginning nearly eleven years ago. Basically, to the AAPS, doctors should not accept payment from Medicare (which it views as unconstitutional) and that the autonomy of doctors, who are portrayed as akin to John Galt and other "producers," should never be constrained by pesky, puny things like evidence-based guidelines, because, apparently, every doctor is expert enough to interpret the vast medical literature without any help.
On the other hand, it is worth briefly mentioning the pure antiscience and pseudoscience that emanates from the AAPS, particularly through its house organ, the Journal of American Physicians and Scientists (JPANDS). This journal is a veritable cornucopia of ideology-motivated quackery and pseudoscience, including antivaccine pseudoscience up to and including the despicable claim that shaken baby syndrome is a "misdiagnosis for mercury poisoning" and that sudden infant death syndrome might be caused by vaccines, the bogus claim that abortion causes breast cancer, and anthropogenic global climate change denialism (don't ask what that's doing there). Indeed, Dr. Jane Orient, the executive director of AAPS, denies the very concept of a scientific consensus.
Well, the Winter 2016 issue of JPANDS is out, hot off the presses, digitally speaking, and I can't help but wonder: What does Dr. Price think of some of the articles found therein. In particular, I'm interested in what he thinks of an article by Neil Z. Miller entitled Aluminum in Childhood Vaccines Is Unsafe. Well, you have to say one thing for Miller: He's consistent. Just two issues earlier, Miller published an article in JPANDS entitled Combining Childhood Vaccines at One Visit Is Not Safe. I'm eagerly looking forward to an ongoing series from Miller: MMR Is Not Safe. Thimerosal Is Not Safe. All Those Nasty Toxins in Vaccines Are Not Safe. Not surprisingly, I took notice of Miller's last article in JPANDS and applied a not-so-Respectful Insolence to misinformation and pseudoscience that deserved much worse. Even less surprisingly, once having seen Miller's second JPANDS publication, I can't resist a repeat, particularly now that I know that Dr. Price is a member in good standing of the AAPS. These are the sorts of misinformation-packed articles that need to be thrown into Price's face during his confirmation hearings in order to force him to justify why he belongs to an organization so opposed to accepted medical science.
So let's take a look, shall we?
Not content with just demonizing aluminum, which is used as an adjuvant for some vaccines. Basically, an adjuvant is a substance that, when injected with vaccines, can result in a more intense immune response. Miller has to start with the dreaded mercury-containing preservative thimerosal. There's a method to his madness, of course. It's not a method that makes any scientific sense, but rather is designed to draw attention from the very simple observation that, since the phase-out of thimerosal as a preservative in vaccines in the US, autism prevalence hasn't declined. Quite the contrary, actually. Miller opines:
From 1999 through 2002, several vaccines containing mercury were phased out of the childhood immunization schedule. Manufacturing of childhood vaccines with thimerosal ceased in 2001, but those that were not past their expiration date remained on the market for sale until January 2003.1 They were replaced with low-mercury or "thimerosal-free" vaccines. In the years that followed, autism rates continued to rise, prompting health authorities to assert that autism is not linked to mercury in vaccines and that vaccination policies are safe and appropriate.2-4 (If mercury in vaccines contributed to autism, then rates should have dropped after mercury was removed.) However, in 2002, during this so-called phase-out period, the Centers for Disease Control and Prevention (CDC) actually added two doses of mercury-containing influenza vaccines to the list of inoculations urged for all babies 6 to 23 months of age.5 Two years later, the CDC also added pregnant women in their first trimester to the list of people officially recommended and actively encouraged to receive influenza vaccines, even though a majority of available doses contained mercury.6
In addition to these questionable actions during this highly publicized "phase-out" of mercury, four doses of a new vaccine with high aluminum content were added to the childhood immunization schedule in February 2000 (for pneumococcus) and two doses of another aluminum-containing vaccine (for hepatitis A) were added in 2005.7,8 These changes to the vaccine schedule resulted in a substantial increase of aluminum-containing vaccine doses—from 10 to 16 injections—that babies are still mandated to receive by 18 months of age.
Notice what Miller left out? Well, he left out multiple things. However, the most glaring is a simple matter of quantity. How much mercury was in the childhood vaccination schedule after 2003 compared to before? The answer, of course, is a lot less, even with the addition of the new vaccines. For instance, in an Italian study from the 1990s testing the existing DTaP vaccine versus a then-new thimerosal-free version, children received 137.5 μg of mercury and just eliminating the thimerosal from the DTaP in that schedule cut mercury exposure by more than half. Moreover, while it's true that most flu vaccines then still contained thimerosal, it didn't take long for manufacturers to get rid of the thimerosal, particularly in the childhood vaccines. These days, it's so hard to find thimerosal-containing flu vaccines that when I get my yearly dose, I often joke about asking to add extra thimerosal.
Of course, the narrative that Miller is selling is that the reason autism prevalence didn't plunge a few years after the removal of nearly all the thimerosal from the childhood vaccine schedule by early 2003 is because of an increase in aluminum exposure. This idea is as much a pile of nonsense as the idea that thimerosal was responsible for an "autism epidemic," not the least of which because it would be an incredibly coincidence that, if you accept the rationale of someone like Miller that both thimerosal and aluminum can contribute to autism, just as one autism-containing vaccine ingredient was removed another was added in sufficient quantity to cause autism prevalence to keep climbing at the very same rate that it was climbing before. That's because antivaccinationists have always known that if autism prevalence kept climbing after thimerosal was removed from vaccines it would be a deadly blow against their belief that thimerosal causes autism when it doesn't. So basically, Miller tries to argue that a 25% increase in aluminum exposure due to vaccines was enough to make up for—scratch that, more than make up for—the loss of thimerosal in its claimed evil autism-causing properties.
To demonstrate the "toxicity" of aluminum, Mr. Miller has to do some rather major contortions, so much so that it looks very much as though he's playing Twister with vaccine science, and the construct can't stand:
Aluminum is neurotoxic and has a long history of well-documented hazards.14 For example, as early as 1921 The Lancet described a 46-year-old metal worker in whom "aluminium produced a rather slow intoxication. In this case it caused memory loss, tremor, jerky movements and incontinence of urine."15 In 1927, Dr. Victor Vaughn, a toxicologist with the University of Michigan, testified before the Federal Trade Commission that "all salts of aluminum are poisonous when injected subcutaneously or intravenously."16 By 1951, Chusid et al. showed that chronic epilepsy could be induced in monkeys through intra-cerebral administration of aluminum hydroxide cream.17 In 1968, Driver et al. performed a similar experiment by placing aluminum hydroxide cream unilaterally on the posterior parietal cortex of six monkeys.18 From 3 to 8 weeks after surgery, electrical abnormalities could be seen on an electroencephalogram and the monkeys exhibited "episodic twitching of the limbs and face." The animals were also impaired at learning new tasks and at re-learning tasks first learned prior to the intervention.
Aluminum exposure in a metal worker in the 1920s was due to a much larger exposure than any vaccine or series of vaccines would be expected to produce. Slathering large quantities of aluminum onto the cerebral cortex is much different than injecting tiny quantities into the muscle. Dose and poison, Mr. Miller. Dose and poison. Learn it, live it, love it. The dose makes the poison, and the dose of aluminum in vaccines is quite safe. I also can't help but notice some of the articles referenced by Miller are not exactly from reliable sources. For instance, reference #16 is from David Ayoub's talk to the National Autism Association Conference in 2007. That's a serious antivaccine conference, and David Ayoub is know for his conspiratorial thinking and belief in black helicopters and the Illuminati. It's not for nothing that Ayoub was inducted into the Encylopedia of American Loons. If you don't believe me, just look for yourself at this typical talk by Ayoub:
That's some weapons-grade crazy.
Mr. Miller also liberally cites Lucija Tomljenovic and Christoper Shaw, two antivaccine cranks par excellence whose abuse of science has been discussed many times here and elsewhere. Let's just put it this way: Tomljenovic and Shaw very much believe that Gardasil causes premature ovarian failure (it doesn't, and here's why) and that it kills (it doesn't, and here's why). Mr. Miller even cites one of the most hilariously misbegotten articles blaming aluminum in vaccines for autism, one that so hilariously confuses correlation with causation that it makes blaming global warming on the decrease in number of pirates seem reasonable by comparison. Yes, it's a Tomljenovic and Shaw paper.
The rest of the paper basically defines the term "cherry picked." Mr. Miller lists, in maximally frightening terms, a series of studies that purport to find significant negative health consequences (as opposed, for instance, to injection site pain or complications, something common to all vaccines, regardless of whether they contain aluminum or not), often by antivaccine cranks, and unsurprisingly ignores the vast existing literature on the safety of aluminum adjuvants. These studies often ignore the principle of "the dose makes the poison":
According to the American Academy of Pediatrics (AAP), "Aluminum is now being implicated as interfering with a variety of cellular and metabolic processes in the nervous system and in other tissues."19 Bishop et al. published data showing that "aluminum accumulates in the body when protective gastrointestinal mechanisms are bypassed, renal function is impaired, and exposure is high."20 For example, in premature infants, "prolonged intravenous feeding with solutions containing aluminum is associated with impaired neurologic development" by 18 months of age. More recently, Kawahara et al. published research confirming that "aluminum can cause severe health problems in particular populations, including infants."21 The authors of this paper also declared that "whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans."
Bloody hell. He's quoting the data for aluminum toxicity in premature infants who have prolonged exposure to aluminum in their parenteral (intravenous) nutrition. We're talking about premature babies who are either too premature or too ill to be fed using their guts and as a consequence have to be fed intravenously and thus receive a lot of aluminum. Comparing this exposure to aluminum to exposure due to vaccines is akin to comparing Mt. Everest to the hill near your house that makes you tired if when you have to climb it.
Unbelievably, Mr. Miller even invokes a favorite antivaccine trope used for any scary-sounding ingredient in vaccines, elaborating on the "injection" aspect of vaccines above:
Moreover, vaccines with aluminum adjuvants are injected into the body, bypassing protective barriers of the gastrointestinal tract and skin. Absorption of aluminum by this mode is more efficient than through ingestion, increasing the likelihood of a toxic outcome. The authors summarized their findings: "Evidence has now emerged showing that autism may in part result from early-life immune insults induced by environmental xenobiotics. One of the most common xenobiotic with immuno-stimulating as well as neurotoxic properties to which infants under two years of age are routinely exposed worldwide is the aluminum vaccine adjuvant."
At least he refrained from the more common variant of this trope, that vaccines are "injected directly into the bloodstream," when in fact they are usually injected intramuscularly. are talking about small amounts of aluminum injected into the muscle, where they are slowly abosrbed.
I could go on and on. Mr. Miller's paper is what we in the skeptic biz call a "target-rich environment." The reason I brought it up now to discuss has less to do with the misinformation in the article, of which there is plenty, or its unusualness, of which there is none. Rather, it's because, now, less than three weeks after Dr. Price was nominated to head HHS, the organization to which he belongs is still at it, publishing antivaccine propaganda every bit as egregious as it's been doing at least since 2006. I don't know about you, but I want to know how many beliefs Dr. Price shares with the organization to which he belongs. I want to see him have to read this article and explain himself, specifically, whether he shares the AAPS's antivaccine views.
Yes, there are a lot of other areas where Dr. Price's views are very worrisome, but this is one that shouldn't be ignored.
Lucija Tomljenovic
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Thank you for going through that.
It's a little sad that so many of the people for c. Whom he wrote that will just accept this.
By Dorit Reiss (not verified) on 21 Dec 2016 #permalink
Orac wrongly states:
"There's no need for me here to reiterate the group's Ayn Rand-like worship of the brave maverick doctor über alles in detail, as I've done that before multiple times beginning nearly eleven years ago. Basically, to the AAPS, doctors should not accept payment from Medicare (which it views as unconstitutional) and that the autonomy of doctors, who are portrayed as akin to John Galt and other "producers," should never be constrained by pesky, puny things like evidence-based guidelines, because, apparently, every doctor is expert enough to interpret the vast medical literature without any help."
...wrong because of its malevolent manipulation of a fact/fiction interpretation;
1) Not only is Medicare unconstitutional, its anti-man. ie., it enslaves the doctor(forced service) & therefore evil.
2) The John Galt reference should be Dr. Thomas Hendricks: In Atlas Shrugged she explains explicitly the proper patient/physician heirarchy through the Dr. Hendricks (! house call !) speech.
3) In essence, what we're going thru now is a quantity/quality dilemma that cannot have a good ending as long as kids are mistakenly taught that democracy(majority) dictates over the individual(smallest minority).
Ideas and individuality have to reign dominant while the popular vote relegated to recessive status.
Yeah, like natures genetic(code) prioritizing - works and has worked for quite some time now ie., forever - in order to control nature, we're better off to obey it - as its got us to where we are today.
'Getting it right' percentages have increased since Ayn Rand laid out the hierarchy of Individualism and supremacy of reason. Evidently this is still not understood nor implemented completely.
Francisco Carlos Domingo Andres Sebastian d'Anconia
By Francisco d'Anconia (not verified) on 21 Dec 2016 #permalink
Jane Orient is dangerously crazy. She should have been stripped of her medical license years ago. From a 2000 newspaper article in Tucson (http://tucsoncitizen.com/morgue2/2000/11/18/172430-internet-blasted-for… ):
A lot of the current information on vaccines "is absolute garbage," said Dr. Jay Lieberman, chief of pediatric infectious diseases at the University of California, Irvine.
Lieberman's comments were part of his "Vaccine: Hit or Myth" address to Tucson area health care workers attending a Southern Arizona Immunization Coalition seminar this week.
Nationwide, there is increasing discussion over alleged but unproven effects of vaccines, including the emotion-laden suggestion that the measles, mumps and rubella vaccine, commonly called MMR, could cause autism in some children.
It's a topic that's recently received time or ink from "20/20," "60 Minutes," USA TODAY and other major media outlets. The Association of American Physicians and Surgeons, a 4,500-member professional group headed by Dr. Jane Orient of Tucson, earlier this month called for a moratorium on government-required vaccines for children.
"Our children face the possibility of death or serious long-term adverse effects from mandated vaccines that aren't necessary or that have very limited benefits," said Orient, who also is president of the Pima County Medical Society.
"This is not a vote against vaccines," she said. "This resolution only attempts to halt blanket vaccine mandates by government agencies and school districts that give no consideration for the rights of the parents or the individual medical condition of the child."
Lieberman said he found the first statement to be appalling.
"The measles vaccine has limited benefit?" he asked incredulously. "That's a statement I would say is absolutely ignorant."
Don't forget the AAPS had Andrew Wakefield as one of their distinguished speakers at their 2011 annual conference (https://www.youtube.com/watch?v=l67fWVrw8xU ).
Like you state, Dr. Price needs to be thoroughly questioned on his membership to this group of physicians who central views pose a threat to public health.
By Chris Hickie (not verified) on 22 Dec 2016 #permalink
Can anyone translate what Francisco posted for me please? I don't speak fluent gibberish.
By Rich Scopie (not verified) on 22 Dec 2016 #permalink
A while back I was going to review Neil Miller's book: "Vaccines: Are They Really Safe & Effective", unfortunately, just too many topics to write on.
Just to give you a taste, on p. 26, he writes: "In 2000, a new study in the Journal of Manipulative and Physiological Therapeutics confirmed earlier findings that children who received DPT or tetanus vaccines are significantly more likely to develop a 'history of asthma' . . . than those who remained unvaccinated." From the actual article: "The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects (adjusted odds ratio, 2.00; 95% confidence interval, 0.59 to 6.74)." For those unschooled in statistics, a confidence interval of 1 means no difference between the groups. A number below 1 would mean that the unvaccinated had higher incidence of disease and, obviously, a number above 1 would be the vaccinated had the higher incidence. When a confidence interval range contains both and is as wide as this one, it means that any finding could be solely due to random chance. Either Mr. Miller just doesn't understand research methods and statistics or . . . ? In any case, this study clearly does not remotely show anything "significantly more likely." Don't believe me; the authors' own conclusion is "Although it is unlikely that these results are entirely because of any sources of bias, the small number of unvaccinated subjects and the study design limit our ability to make firm causal inferences." The conclusion should have simply read the results were inconclusive. Claiming that they can't make "firm causal inferences" would be like tossing a coin a few times and claiming one couldn't make a firm causal inference as to the coin being balanced or not. The article Miller is citing is: Eric L. Hurwitz, DC, PhD, Hal Morgenstern, PhD (2000 Feb). "Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States," Journal of Manipulative and Physiological Therapeutics; 23(2): 81-90.
So far the vast majority of citations in this book seem to be from other books and articles written by anti-vaccine advocates without any evidence the author checked out the original sources and, so far, when he has used original sources, as from the above example, he draws totally unwarranted conclusions.
Finally, PubMed adds approximately 20,000 new articles per month. I could prove any point I wanted by finding a few articles. And some may be quite legitimate; but the difference between science and other endeavors is that once published other researchers will try to replicate findings or go beyond them. Even the results of well-done studies can be affected by random variables, which is why replication is necessary.
As an example, another study of DTP and asthma followed a population-based birth cohort of 13,971 children until they were 7.5 years old and found no significant association. (Anirban Maitra et al. (2004 Apr 17). "Pertussis vaccination in infancy and asthma or allergy in later childhood: birth cohort study," BMJ; 328: 925-926)
By Joel A. Harris… (not verified) on 22 Dec 2016 #permalink
https://cdn.meme.am/instances/18969897.jpg
By Delphine (not verified) on 22 Dec 2016 #permalink
"The dose makes the poison, and the dose of aluminum in vaccines is quite safe."
No, that's wishful thinking based on broken research, see below.
Dr. Mitkus,
I was reviewing aluminum safety information for vaccines at the FDA website and found your study.1
You provide the following description of the effect of aluminum adjuvants on the immune system.
"Aluminum adjuvants are important components of vaccines, since they stimulate the immune system to respond more effectively to protein or polysaccharide antigens that have been adsorbed to the surface of insoluble aluminum particles. Specifically, these coated particles are phagocytized by cells of the innate immune system (e.g., macrophages) and activate intracytoplasmic sensors of pathogen-associated molecular patterns located within the cells, such as the nucleotide-binding domain leucine-rich repeat-containing family of sensors ([6]; Schroder and Tschopp [30]). The functional consequence of activation of this intracellular system is the activation of certain enzymatic caspases that cleave pro-interleukin (IL)-1β to interleukin (IL)-1β. The secretion of the mature cytokine, IL-1β, leads to an inflammatory reaction and a downstream Th2-dependent antibody response [7], which amplify the immune response to the antigen. Adjuvanted aluminum, therefore, plays a vital role in facilitating the response that underlies the immunoprotection afforded by vaccines."
The rest of the paper focuses on body burden of aluminum AFTER it is absorbed from the muscle into the blood.
I was taken aback that you have COMPLETELY IGNORED any negative immunological effects that aluminum can have while it is still in the muscle.
The quoted paragraph above assumes that the only proteins in the vaccine are viral/bacterial proteins. In that case, as you state, the stimulation by aluminum plays a vital role in generating immunoprotection.
But obviously, vaccines contain numerous other proteins including food proteins (ovalbumin, milk, soy, yeast, etc.)2 , culture medium cell proteins (Vero monkey kidney cell proteins, calf serum proteins, WI38/MRC5 fibroblast cell proteins, etc.) that are also adsorbed to the surface of insoluble aluminum particles. As you state then, aluminum adjuvants stimulate the immune system to respond more effectively to ALL these proteins as well. The effect is an immune response that includes synthesis of antibodies against any and all of these proteins. The result of such a response of course includes food allergy3,4,5 and autoimmunity6.
How can you perform a safety assessment of aluminum in vaccines by COMPLETELY IGNORING this effect?
1. Mitkus RJ, King DB, Hess MA, Forshee RA, Walderhaug MO. Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine. 2011 Nov 28;29(51):9538–43.
2. Vaccine Excipient & Media Summary [Internet]. 2015 [cited 2016 Jan 16]. Available from: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipi…
3. Arumugham V. Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy. J Dev Drugs. 2015;4(137):2.
4. Platts-Mills TAE. The allergy epidemics: 1870-2010. Journal of Allergy and Clinical Immunology. 2015. p. 3–13.
5. Alice Hoyt, Peter Heymann, Alexander Schuyler, Scott Commins TAEP-M. Changes in IgE Levels Following One-Year Immunizations in Two Children with Food Allergy [Internet]. 2015. Available from: https://wao.confex.com/wao/2015symp/webprogram/Paper9336.html
6. Dahan S, Tomljenovic L, Shoenfeld Y. Postural Orthostatic Tachycardia Syndrome (POTS)--A novel member of the autoimmune family. Lupus. 2016 Apr 1;25(4):339–42.
By vinu arumugham (not verified) on 22 Dec 2016 #permalink
You cited yourself, and a study co-authored by Tomljenovic and Shoenfeld.
You really are making this too easy for us, Vinu.
By Julian Frost (not verified) on 22 Dec 2016 #permalink
They are peer-reviewed published references. Just because you disagree does not make the findings go away ...
Dr. Mitkus and the FDA made it very easy for me too ...
Absolutely, Julian. Not only does Vinu cite himself but in a predatory journal, too. Boasts a 4-5 week peer review and publish timeline. Not to mention that he completely mis-quotes his source #2. Fish in a barrel, really.
By JDK (not verified) on 22 Dec 2016 #permalink
Could you please be specific about what you think was mis-quoted?
In reply to by JDK (not verified)
My publication was featured here:
Recent publications from the NIH Immunology Interest Group
https://list.nih.gov/cgi-bin/wa.exe?A2=ind1511&L=immuni-l&F=&S=&P=49179
Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy.
Arumugham V J Develop Drugs 4: 137, 2015 doi:10.4172/2329-6631.1000137
Response in the British Medical Journal
Vaccines cause the development of food allergies: the latest evidence.
http://www.bmj.com/content/355/bmj.i5225/rr-0
Comments in the New England Journal of Medicine
http://www.nejm.org/doi/full/10.1056/NEJMp1607762#t=comments
Dr. Orient is also head of the closely associated Doctors for Disaster Preparedness, and winner of their first "Petr Beckmann Award for courage and achievement in defense of scientific truth and freedom", named after a notorious relativity crank.
Apparently it's an award for the "courage" and "freedom" to be persistently, irrationally wrong.
By Dan Riley (not verified) on 22 Dec 2016 #permalink
Whenever I see 'JPANDS' I get a mental image of adult diapers.
Tom Price is one scary dude, but there's no reason to assume he's anti-vax because he's in an organization the includes anti-vaxers. I've belonged to a few academic organizations, and a couple political ones, over the years, and while each had some overall direction, there was a wide spectrum in interests and interest in the membership. By 'interest' (singular) I mean level of participation – I paid dues to one political organization because a friend was an organizer and i wanted to get the newsletter. I never went to a meeting, didn't necessarily agree with any positions taken by other members – which were hardly lock-step either, as there was a lot of internal debate...
Anyway, Price does not seem to be a 'stealth' kinda guy, and he has a public record. Beyond that, you could probably track whether he's been active in any AAPS activities – conference appearances, serving as an officer, working on the journal, etc. etc. – and, through that, which of the groups positions account for his membership, if any (he could just be keeping himself on the rolls for political purposes, hitting them up for campaign funds).
My guess, based on his public statements, is that his connection to the group is the Randian physician autonomy and anti-insurance stand – which he seems not to take exactly über alles, but pretty close. That's not anti-vax, but it's pretty obviously not pro-vax either: thou shalt not question thy fellow doctor-deities judgement that a medical exemption or delayed schedule is Right for His patient, thou shalt not abide by Big Government coercing anyone to inject their child-property with anything before sending them to the school of their choice. Etc. etc.
Laissez faire. Let the market decide. Free-dumb. It's been reported in the comments here that Price's personal opinion is that anti-vaxers are wackos. But if Price's own wacko is a radical 'hands off' of any other kind of wack spouted by anyone who can paste 'MD' after their name, it hardly makes any difference what he thinks of vaccines. Even if he did think they were behind some still advancing 'ASD epidemic', he wouldn't answer the AVs dreams and regulate against them.
We know the agenda: repeal Obamacare; play golf with Donald; talk about Health Savings Accounts; repeal Medicare... Lather, rinse, repeat.
By sadmar (not verified) on 22 Dec 2016 #permalink
Speaking of "dangerously crazy", Neil Z. Miller is known for his claims of communicating with extraterrestrials, and for facilitating interactions between said alien beings and his daughter. Both have authored books about their revelations. Here's one by Neil (a.k.a. "Z-Man"):
http://thinktwice.com/gadzooks.htm
http://thinktwice.com/poems.htm
It'd be fun and instructional to have reporters/members of Congress quiz Tom Price about how he feels belonging to an organization which publishes work by an antivaccine crank who claims to communicate with extraterrestrial beings.
By Dangerous Bacon (not verified) on 22 Dec 2016 #permalink
Rich@4: I don't speak fluent gibberish either, at least the Ayn Rand variety, but the poster to whom you refer takes his nym from a prominent character in Atlas Shrugged. That tells me everything I need to know about him.
As for this from the original post:
It's not a method that makes any scientific sense, but rather is designed to draw attention from the very simple observation that, since the phase-out of thimerosal as a preservative in vaccines in the US, autism prevalence hasn't declined. Quite the contrary, actually.
At least our anti-vaccine loons are learning. Not fast enough, of course, but at least this one is aware that the thimerosal gambit won't work anymore.
By Eric Lund (not verified) on 22 Dec 2016 #permalink
@ # 2 Francisco d'Anconia
Thank you for your post. Posters who disagree with our host are usually not so specific, and kind as to directly provide such strong evidence in support of the Perspex Personage's points, even going so far as your Nom d' Internet. Your generosity will long be appreciated and your distinguished self held as an exemplar.
By sirhcton (not verified) on 22 Dec 2016 #permalink
"communicating with extraterrestrials"
I've always wondered if all the people who claim to converse with extraterrestrials are talking to the same or different ones. And do the said ETs collaborate and share notes about their side of the conversations with us. And can they get their papers about us published in the ET-peer science journals.
By rs (not verified) on 22 Dec 2016 #permalink
Gotta love those who equate medicare with slavery, after all, being paid by an agreed upon schedule is slavery.
Just ask the pre-civil war slaves about their pay schedule.
Oh wait, slavery is by definition unpaid and paid per performance and payment schedules are not slavery. They're simply conducting an honest business.
As for aluminum being so toxic, if aluminum is so toxic to you, return to your planet of origin. You're an illegal space alien and don't belong here.
Aluminum is the most common metallic element on earth and the third most abundant element in the earth's crust. If you can't survive it, return to your home planet of Stupidia.
Now, please excuse me while I go make some french toast from the leftover bread that I baked yesterday evening - on an aluminum bake pan. A sheet pan that's seen decades of usage.
Their nonsense is nearly as bad as the dihydrogen monoxide ban efforts, Libertarian history and phlogiston.
By Wzrd1 (not verified) on 22 Dec 2016 #permalink
"Aluminum is the most common metallic element on earth and the third most abundant element in the earth's crust."
Water is abundant too. Have you tried living underwater?
Just because it is abundant, how does it become safe to inject yourself with it?
If "Francisco d'Anconia" thinks that Dr. Thomas Hendricks is a more appropriate representation of the AAPS's view of an ideal physician, I won't argue with him after reviewing this description of Dr. Hendricks:
After her crash landing in Galt's Gulch, Dagny has a sprained ankle and some mild cuts and bruises. (This is the worst injury that any of Ayn Rand's protagonists ever suffer, because if she allowed them to be seriously injured or disabled, it'd raise difficult questions of who would pay for their treatment and support them through their recovery.) So she arranges to be seen by the resident doctor, a surgeon named Dr. Thomas Hendricks.
Like the other inhabitants of the Gulch, Dr. Hendricks tells Dagny that he quit his practice because there was too much government red tape and he'd gotten fed up with it: "I would not let them dictate the purpose for which my years of study had been spent, or the conditions of my work, or my choice of patients, or the amount of my reward."
The only plausible reading of this is that Dr. Hendricks wanted the "freedom" to pick and choose his patients, charge as much as he pleased, and turn away sick people who couldn't meet his fees. Because, of course, how much a person can pay should be the first thing any good doctor thinks about.
He also tells her that he's continued to do medical research—where he procured test subjects for human trials is never addressed—and has invented a cure for strokes. Yes, all strokes. But he'll never share his finding with the world because ordinary peons don't deserve to benefit from his scientific genius:
"No, Miss Taggart, I have not given up medicine," said Dr. Hendricks, in answer to her question. "I have spent the last six years on research. I have discovered a method to protect the blood vessels of the brain from that fatal rupture which is known as a brain stroke. It will remove from human existence the terrible threat of sudden paralysis... No, not a word of my method will be heard outside."
You might think that a doctor's first responsibility is to help the sick, and not to deliberately withhold lifesaving medical advances (that is, if you were the American Medical Association). But, if you live in Galt's Gulch, you'd be wrong.
Yes, that does sound very much like the AAPS vision of how medicine should be practiced: Total physician autonomy, money over patient care, and an unshakable belief that as a physician you are so superior that it's morally acceptable to withhold knowledge of a scientific discovery that could save millions of lives because you consider the rabble undeserving of the fruits of your genius and save that information only for those among your clique of "supermen."
I stand corrected. From this day forward, when discussing the AAPS, I will point to Dr. Hendricks as the epitome of what the AAPS thinks a good doctor should be and AAPS members think they are, given that Hendricks is portrayed as almost supernaturally skilled at surgery and medicine.
By oracknows on 22 Dec 2016 #permalink
https://cdn.meme.am/cache/instances/folder857/400x400/46012857.jpg
"No, Miss Taggart, I have not given up medicine," said Dr. Hendricks, in answer to her question. "I have spent the last six years on research. I have discovered a method to protect the blood vessels of the brain from that fatal rupture which is known as a brain stroke. It will remove from human existence the terrible threat of sudden paralysis… No, not a word of my method will be heard outside."
My experience with Ayn Rand's writing has mercifully been limited to excerpts, but seriously, she's presenting this guy as one of the so-called good guys? In that paragraph, he sounds like a cartoonish villain. Dr. No and Lex Luthor are more convincing than Dr. Hendricks.
Reading Orac's reference in #17 ( which describes Rand's ..er.. art form) , I can only say- that 'Fall of NY' part sounds like what Mikey and the other idiot portray frequently- everything will come crashing down inevitably and only those who who know how to compete in chaos ( with woo-meisters' help, of course) will survive.
They have a very simplistic, black and white view of hoiw society functions.
By Denice Walter (not verified) on 22 Dec 2016 #permalink
Like Eric, my interactions with Rand's "literature" are thankully brief ( I read the Fountainhead when I was 15 or so) but enough to form a strong impression that I didn't want to read any more.
@ rs:
Probably they communicate with different ETs who then collaborate on what to reveal to earthlings so that sciifi screenwriters will get the message out correctly.
Ever notice how they tend to look alike after the Close Encounter film became popular? That was planned.
Like Eric, my interactions with Rand's "literature" are thankully brief ( I read the Fountainhead when I was 15 or so) but enough to form a strong impression that I didn't want to read any more.
I read Atlas Shrugged at about age 14. My advisor's wife once said that the only excuse for reading Ayn Rand is being a 14 or 15 year old girl.
By JP (not verified) on 22 Dec 2016 #permalink
# 19 Eric Lund
My experience with Ayn Rand's writing has mercifully been limited to excerpts,
I am not sure but I think it takes a very bizarre mindset to read Rand other than as an academic exercise. As a teenager living in the country where reading material could be a bit sparse I found myself so disgusted with the horribly unrealistic plotting and characters that I stopped reading the book. And I'd read bus schedules for pleasure—though I preferred/prefer train schedules.
Dr. No and Lex Luthor are more convincing than Dr. Hendricks.
Sound par for the Rand course.
# 21 Denise Walters
I wonder if that was the one I tried reading. My reaction was definitely the same.
By jrkrideau (not verified) on 22 Dec 2016 #permalink
Eric Lund: "My experience with Ayn Rand's writing has mercifully been limited to excerpts, but seriously, she's presenting this guy as one of the so-called good guys?"
At the beginning of the book the female protagonist encounter John Galt in what many would interpret includes rape. Which makes sense since Ayn Rand had sexual relations with her followers. Darryl Cunningham's graphic book Supercrash goes into details, it is a good read.
By Chris (not verified) on 22 Dec 2016 #permalink
@JP: I assume you are familiar with the John Rogers quote on the subject:
There are two novels that can change a bookish fourteen-year old's life: The Lord of the Rings and Atlas Shrugged. One is a childish fantasy that often engenders a lifelong obsession with its unbelievable heroes, leading to an emotionally stunted, socially crippled adulthood, unable to deal with the real world. The other, of course, involves orcs.
I don't know whether my sample is representative, but I hear of far more male adherents of Ayn Rand than female adherents.
I find it hard to believe that these 'scientists' are really so ignorant about basic chemistry, even if they are just pseudoscientists. Not only do they ignore the basic adage "the dose makes the poison", but they seem to be completely ignorant about the actual chemical properties of vaccine adjuvants and their toxicity profile.
Apart from the insignificant dose from a viewpoint of toxicity (there is already more aluminum naturally present in the body than the amount in a vaccine), the aluminum is present in a compound form, either aluminum hydroxide or aluminum phosphate. Both compounds have a very low solubility, which means that they only disperse very, very slowly from the injection site -- IIRC, it can take up to two or three weeks for the 1-2 milligrams of aluminum adjuvants to disappear from the injection site (a rather persistent 'knot' at the site is also a common side effect of these vaccines). And most of what reaches the blood is excreted through the kidneys. What this means is that even if the aluminum from a vaccine somehow reaches the brain, it only does so in absolutely tiny amounts, in the order of a few micrograms per day. The daily exposure from aluminum through ingested food is already higher, even for small infants.
These simple facts must have been explained to antivaccine cranks thousands of times, yet still they keep trotting out their 'toxins' gambit... Either these people are not capable of learning, or they are plain dishonest, and willingly keep lying for their cause.
By Richard (not verified) on 22 Dec 2016 #permalink
I notice that someone on this thread (you can guess who) has taken to e-mailing me at my work e-mail address. So I'm going to reiterate my longstanding policy: I ignore any blog-related e-mail sent to either of my work e-mail addresses, be it my cancer center e-mail address or my university address. The only exception I'll sometimes make is for reporters who want to interview me, and even then I'll usually ask them to use the blog e-mail address.
Richard #32,
"IIRC, it can take up to two or three weeks for the 1-2 milligrams of aluminum adjuvants to disappear from the injection site (a rather persistent 'knot' at the site is also a common side effect of these vaccines)."
Yes, please see #7. What happens at the injection for those two or three weeks, is being ignored. Aluminum adjuvants bias for allergy. With numerous allergens injected with vaccines, people develop allergies.
I notice that someone on this thread (you can guess who) has taken to e-mailing me at my work e-mail address . . .
Although I think that behavior on their part is indeed inconsiderate at best, at least it puts them a step above those that wail about your hiding your real/super secret identity behind a pseudonym. They have failed the how-to-use-the-internet test.
TWO? We now have two monomaniacal numpities blithering on here? Isn't one enough?
By JustaTech (not verified) on 22 Dec 2016 #permalink
I imagine that Spielberg designed his aliens based on a composite appearance from former literature and 'abduction' (1961) reports.
In the 1893... H.G. Wells had envisioned the possibility of humanity transformed into a race of grey-skinned beings; who were perhaps 1 meter tall, with big heads and large, oval-shaped pitch black eyes....
In 1933, the Swedish novelist Gustav Sandgren,... published a science-fiction novel... in which he describes a race of extraterrestrials: "...the creatures did not resemble any race of humans. They were short, shorter than the average Japanese, and their heads were big and bald, with strong, square foreheads, and very small noses and mouths, and weak chins. What was most extraordinary about them were the eyes—large, dark, gleaming, with a sharp gaze...
Neurologist Dr. Steven Novella argues that the Grey idea is a byproduct of the human imagination, with the Greys' most distinctive features representing everything that modern humans traditionally link with intelligence.
https://en.wikipedia.org/wiki/Grey_alien#History
Praying mantis face aliens do seem to be the norm for quite some time though Speilburg did solidify it into modern culture.
By Gilbert (not verified) on 22 Dec 2016 #permalink
To crib from my old friend, Driftglass:
DUMB^SS SHRUGGED
By Robert L Bell (not verified) on 22 Dec 2016 #permalink
I notice that someone on this thread (you can guess who) has taken to e-mailing me at my work e-mail address.
Sheesh, you must have been low on the totem pole. There've already been, at a bare minimum, the really irritated guy from the mailing list and the CDC researcher who "thanked" APV for bringing the crankery to his attention. L-rd only knows whom else he's been spamming.
By Narad (not verified) on 22 Dec 2016 #permalink
Aluminum is far more evil than you know.
http://www.watchthetower.net/alum2.html
By Mark Thorson (not verified) on 22 Dec 2016 #permalink
As a retired emergency planner/current emergency volunteer, I don't know whether to laugh or kick the dog at "Doctors for Disaster Preparedness."
By shay simmons (not verified) on 22 Dec 2016 #permalink
Vinu, #34
With all due respect, but vaccines are most definitely not associated with the development of allergies. Yes, the described side effect (nodule at the injection site) is in fact the symptom of an immune (over)reaction, but this always resolves without residual effects as soon as the aluminum compound is cleared from the site. As far as I can see in the literature, subsequent aluminum-containing vaccinations do not cause increasingly strong responses, something one would expect in the case of a newly acquired allergy.
So the claim that vaccines are a significant cause of allergies and other conditions of the immune system is plain nonsense.
"As far as I can see in the literature, subsequent aluminum-containing vaccinations do not cause increasingly strong responses, something one would expect in the case of a newly acquired allergy."
Please see this:
Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines.
https://wao.confex.com/wao/2015symp/webprogram/Paper9336.html
How do you explain that?
"With all due respect, but vaccines are most definitely not associated with the development of allergies."
Evidence shows otherwise ...
In reply to by Richard (not verified)
@ JP:
You are correct altho' I doubt that either of us were average 14 or 15 year old girls.
@ Eric Lund:
I think that you're right: I have heard MANY male adherents but I don't think that I ever heard of a single female.
There must be a reason for that .
@ vinu, #42
Sorry, but I have to call total BS on your 'evidence'. Had you done your homework, you would have found that these cases of limb swelling are exceedingly rare: researchers using the VAERS database identified less than 500 cases in a 13-year time period -- on a total of almost two billion vaccinations, see http://cid.oxfordjournals.org/content/37/3/351.full. This means that this particular reaction is observed in less than one in a million vaccinations. Your second link involves data on merely two children.
I really hope you enjoy them self-picked cherries. No doubt you'll offer us some more yet.
Yes, vaccines sometimes cause an allergic reaction, e.g. to egg protein or gelatin, or to the actual immunogen (the latter is also suggested in your first link). And I explicitly said that the aluminum can cause a local immune (over)reaction. But these reactions are rare, and do not lead to other allergies or immune system problems.
In general, there is no evidence that vaccination is a significant cause of allergies, and vaccinated children are no more prone to allergies than unvaccinated children.
The aluminum adjuvant also has no long-term effects that we know of.
Please explain this:
"two children"
In a WELL CONTROLLED experiment, it was IMMEDIATELY OBVIOUS with just two children, that food protein contaminated vaccines BOOSTED food allergy.
Please explain those results.
"rare vaccine reaction"
It is rare because of low levels of allergen quantities in a vaccine. With ingested foods, the protein quantities involved cause reactions to be more common and severe.
"exceedingly rare"
Rare or not, you have to accept now, that SENSITIZATION DID OCCUR.
@vinu, #47
So? Vaccines sometimes cause allergic reactions. We know that. And if you have children with existing allergies, yes, chances are that those allergies are exacerbated when the immune system is activated through immunization. And in the period after immunization, things return to normal -- i.e. those children will still have their food allergies, but not worse than before.
Let's put it like this: you come up with studies that clearly show that allergies of any sort are more prevalent among vaccinated children, and I will start believing you. Large population numbers, that's what I want to see. Not studies of just a (very) small subset of carefully selected individuals with pre-existing conditions, or speculative conclusions derived from known side effects.
So far, allergies are correlated mostly with urban life, i.e. less contact with animals and microbiota at a young age, and more air pollution. There is no compelling evidence that vaccination has anything to do with it, apart from rare individual cases.
"And if you have children with existing allergies, yes, chances are that those allergies are exacerbated when the immune system is activated through immunization."
So an influenza immunization can boost your protection against tetanus and pertussis due to "the immune system is activated through immunization"?
A tetanus booster shot only boosts tetanus protection, a diphtheria booster would do the same for diphtheria. You boost milk allergy with a milk containing vaccine. It is not rocket science.
You have not responded to the IOM finding.
https://www.omicsgroup.org/journals/evidence-that-food-proteins-in-vacc…
"Yamane et al. [8] demonstrated
a significant increase in anti-ovalbumin IgE in 36 out of 100 subjects
following influenza vaccination."
"Let's put it like this: you come up with studies that clearly show that allergies of any sort are more prevalent among vaccinated children, and I will start believing you."
That's a joke.
1. One has to PROVE that it is safe to inject food proteins into people BEFORE injecting the whole population with it.
2. Unvaccinated populations are small, so you will conveniently dismiss any findings as insignificant.
3. No controlled studies are possible because of circular reasoning stating that "vaccines are safe and effective" so vaccines cannot be withheld from a group of children for study purposes, due to "ethical" reasons. While it is considered ethical to sicken 8% of the population with vaccine-induced food allergies.
"allergies are correlated mostly with urban life, i.e. less contact with animals and microbiota at a young age,"
Yes, that is PREDISPOSITION to allergy. How does that sensitize you to a PARTICULAR allergen?
The worst thing we can do to "urban life" children predisposed to allergy, is to inject them with aluminum adjuvanted food allergen contaminated vaccines. A perfect recipe for the disaster known as the food allergy epidemic.
Repeated bee stings cause bee sting allergy.
Repeated milk containing vaccinations cause milk allergy.
Repeating the same thing over and over and expecting a different result, is defined as insanity.
"Repeating the same thing over and over and expecting a different result, is defined as insanity."
"Repeated milk containing vaccinations cause milk allergy."
Really? Then, when my oldest child was diagnosed as having an allergy to cow's milk before he'd ever had any vaccination, it must have been the Alien Pharma Overlords in their time machine, sneaking into the hospital nursery and sticking needles into his tiny little body? I mean, what else could it be? Obviously nobody had any food allergies until vaccines were invented.
By Ellie (not verified) on 23 Dec 2016 #permalink
Never claimed vaccines are the ONLY cause of food allergies. They are the MOST EFFICIENT cause of food allergies. That is why, researchers use injections of food proteins + alum (same as vaccines) to RELIABLY induce food allergy in lab rats/mice.
In reply to by Ellie (not verified)
Sensitization can occur through the following routes of allergen exposure. Injection, respiratory, damaged skin (lotion) and ingestion.
May be you can educate us on the route of exposure in your son's case?
vinu #51
What vaccines contain milk?
By Chemmomo (not verified) on 23 Dec 2016 #permalink
Any vaccine that uses casamino acids or casein is contaminated with milk proteins. Daptacel, Pentacel, Prevnar 13, Tenivac, Infanrix, Kinrix, Pediarix, Menomune and Boostrix are all contaminated with milk proteins.
http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm…
Kattan JD, Cox AL, Nowak-Wegrzyn A, Gimenez G, Bardina L, Sampson HA, et al. Allergic reactions to diphtheria, tetanus, and acellular pertussis vaccines among children with milk allergy. J Allergy Clin Immunol. 2011;Conference(var.pagings):AB238
In reply to by Chemmomo (not verified)
"• Vaccination helps children with asthma or allergic disease by reducing their likelihood of getting a serious infection which could worsen their asthma or allergy symptoms.
• Vaccines very rarely produce an allergic response, and therefore most children with allergies (e.g. to most environmental and food allergens) can safely be vaccinated.
• Well-performed studies show no increase in allergy or asthma due to use of routine childhood vaccines. Although asthma and allergic disease rates have increased in the past few decades, the reason for this remains unknown.
• While it has been suggested that vaccines may contribute to the rise in allergic disease because they prevent childhood infections (the 'hygiene hypothesis'), this theory does not apply to vaccine-preventable diseases."
http://www.ncirs.edu.au/assets/provider_resources/fact-sheets/vaccines-…
That is outdated.
The US Dept. of Health and Human Services (HHS) charged the Institute of Medicine (IOM) with providing a thorough review of the current medical and scientific evidence on vaccines and vaccine adverse events. They reviewed the entire vaccine related medical literature from 1950.
The IOM has concluded in its 2011 report that:
FOOD PROTEINS PRESENT IN VACCINES CAUSE THE DEVELOPMENT OF FOOD ALLERGIES.
Antigens in the vaccines that the committee is charged with reviewing do not typically elicit an immediate hypersensitivity reaction (e.g.,
hepatitis B surface antigen, toxoids, gelatin, ovalbumin, casamino acids).
In reply to by Dangerous Bacon (not verified)
Numerous details and references:
http://www.centerforinquiry.net/forums/viewthread/18997/
"Although asthma and allergic disease rates have increased in the past few decades, the reason for this remains unknown."
ex·pert
1.a person who has a comprehensive and authoritative knowledge of or skill in a particular area.
When people admit they don't know, then they are admitting they are no longer experts. So, start looking for advice elsewhere.
Is it not interesting that people reject Dr.Richet's finding because it is from a hundred years ago, yet every time they step on a plane, they are depending on the findings of Bernoulli and Newton more than 300 years ago?
"We are so constituted that we can never receive other proteins into the blood than those that have been modified by digestive juices. Every time alien protein penetrates by effraction, the organism suffers and becomes resistant. This resistance lies in increased sensitivity, a sort of revolt against the second parenteral injection which would be fatal. At the first injection, the organism was taken by surprise and did not resist. At the second injection, the organism mans its defences and answers by the anaphylactic shock."
According to Vinu @#59, Dangerous Bacon's 2014 reference @#58 has been outdated by a 2011 reference.
Methinks Vinu's not reading, or at the very least not comprehending, the references that others are giving.
By Stuartg (not verified) on 23 Dec 2016 #permalink
The relevant references in Dangerous Bacon's 2014 reference predate the 2011 IOM findings.
In reply to by Stuartg (not verified)
vinu: Do you know how time works? Here's a hint: 2011 comes before 2014, not the other way around.
By Politicalguineapig (not verified) on 23 Dec 2016 #permalink
Pl. see #64.
In reply to by Politicalguineapig (not verified)
@ vinu, #50 and further
What you are perpetrating here is known as the Gish Gallop: as soon as an opponent addresses a particular point of yours, you retort by drowning the opponent in a whole lot of new BS points.
It really is quite simple: you cannot show solid evidence that vaccines are unsafe or cause allergies in any significant way -- simply because there is no solid evidence. So, for the time being, let's keep it at that, shall we?
What's you complaint about this evidence?
Antigens in the vaccines that the committee is charged with reviewing do
not typically elicit an immediate hypersensitivity reaction (e.g.,
above-mentioned antigens do occasionally induce IgE-mediated
sensitization in some individuals and subsequent hypersensitivity
reactions, including anaphylaxis."
Richard @ 67, whereas it's trivial to show the same relationship between vaccines and allergies that any other substance that contains an antigen has with allergies. Alas, that's very nearly entirely random and thankfully, rare.
Although, some things are less rare, such as latex (my wife and daughters are all allergic to latex and shellfish proteins (my wife and our youngest daughter are allergic to shellfish - badly so). But, some people can have a severe reaction to even sterile saline injection.
Of course, that's simple reality. Something vinu seems to be unacquainted with.
Vaccines were contaminated with latex (rubber vial stoppers) in the past. Pharmaceutical products can be contaminated with foods including seafood. You are what you eat and you are what you inject.
https://www.nap.edu/catalog/23658/finding-a-path-to-safety-in-food-alle…
NAM report pg.241
"Allergens in Vaccines, Medications, and Dietary Supplements
Physicians and patients with food allergy must consider potential food allergen exposures in vaccines, medications, and dietary supplement products (e.g., vitamins, probiotics), which are not regulated by labelling laws.
Also, excipients (i.e., substances added to medications to improve various characteristics) may be food or derived from foods (Kelso, 2014). These include milk proteins; soy derivatives; oils from sesame, peanut, fish or
soy; and beef or fish gelatin. The medications involved include vaccines; anesthetics; and oral, topical, and injected medications. With perhaps the exception of gelatin, reactions appear to be rare overall, likely because little residual protein is included in the final preparation of these items. The
specific risk for each medication is not known.
Vaccines also may contain food allergens, such as egg protein or gelatin."
" With perhaps the exception of gelatin, reactions appear to be rare overall, likely because little residual protein is included in the final preparation of these items."
"Vaccines also may contain food allergens, such as egg protein or gelatin."
Note how the two statements say pretty much the same thing, despite your repeated gish gallops.
Note also that only some vaccines are made from chicken eggs, hence would have egg proteins possibly present (and such is documented in the package insert).
Griping about what's already documented and indeed, something like an egg allergy is a listed contraindication for vaccines made from chicken eggs, isn't a valid argument whatsoever. It's like complaining that one could get rained upon because one got a sunburn.
You are confusing two separate concepts. We are NOT talking about REACTIONS. We are talking about the DEVELOPMENT of food allergy in healthy people, due to these contaminated injections. Once they develop allergy (sensitization), then of course all the warnings of reactions apply.
The MISSING part is that NO ONE will warn you (on the package insert) that a healthy person can develop allergy following the injection.
A healthy person can develop an allergy at any time. Not only via injection or a first exposure to an antigen, it can happen at any exposure to an antigen. First, five thousandth exposure, any time.
Vinu: You're still wrong. Nothing in 2014 can predate 2011. What you are saying is that 2014 was an earlier year than 2011, therefore the findings in 2011 are more valuable. However, here on planet earth, 2014 was three years later than 2011, and that is ample time for new information to be found. Did you drop out of grade school? The average first grader would know this stuff.
Also as far as Dr. Richet goes, I have no doubt he was probably a very smart man, but keep in mind that the state of medical practice in 1913 was very different from today. They didn't even know about viruses back then, or for that matter, have penicillin.
A lot of what was standard practice and accepted knowledge back in 1913 has been understood to be false or incomplete as doctors got access to new technology and improved their methods. That's this little thing we on planet earth like to call progress.
PGP @ 70, I dunno about progress.
Today, we'd be hard pressed to construct the pyramids the same way.
We'd use reinforced concrete and steel, being totally lazy and all. ;)
I'll just get my coat...
The 2011 report is an authoritative report from the IOM based on a review of ALL vaccine literature from the 1950s. It was commissioned to provide the scientific basis for the Vaccine Injury Table. The 2014 document is obviously missing the important findings from the IOM report and therefore is out of date.
Dr. Richet:
How do you explain the fact that the IOM report completely agrees with Dr.Richet's finding from a hundred years ago?
vinu, have you ever heard of the arrow of time?
You keep referring to the 2011 report as if it showed that the IOM concluded that vaccines can cause food allergies. But it does not say so in the clause you quote, and if you follow the other places where the IOM addressed "IgE-mediated" or hypersensitivity it's talking about allergic reaction to the vaccine, not about creation of allergies.
So not only, as pointed out, is your source less new than 2014, but I don't see what evidence in it supports your claim. A paragraph that can be interpreted to vaguely support it?
Would you like to point to any actual data in the report supporting you?
IOM:
"However, as will be discussed in subsequent chapters, the
above-mentioned antigens do occasionally induce IgE-mediated sensitization in some individuals and subsequent hypersensitivity reactions, including anaphylaxis."
Sensitization means DEVELOPMENT of allergy anew.
Subsequent exposure would of course result in hypersensitivity reactions, including anaphylaxis.
Show where in the report - where in subsequent chapters - was development of allergies anew.
You made a specific claim. That specific proteins in vaccines lead to the development of food allergies. You claimed the IOM report supports it. Please show where it shows that.
You are still not reading the whole paragraph?
It lists several antigens as examples.
It says the above mentioned antigens cause IgE mediated sensitization (development of allergy). So specific antigens casamino acids (cow's milk derived) cause milk allergy, ovalbumin causes egg allergy, gelatin causes gelatin allergy, toxoids cause allergy to tetanus/diphtheria vaccines, etc.
Antigens in the vaccines that the committee is charged with reviewing do not typically elicit an immediate hypersensitivity reaction (e.g.,hepatitis B surface antigen, toxoids, gelatin, ovalbumin, casamino acids).
And I'm asking you to point out where in subsequent chapters the IOM found that vaccines create those allergies.
Because aside from some small studies about gelatin from Japan that are not very strong as evidence of causation and were also covered by later sources, I don't see the IOM citing any such cases.
If you want to use the report to claim the IOM found that vaccines create allergies to these proteins you should be able to point to the actual cases cited, not one potentially badly phrased general paragraph in a general chapter. I looked. Can you show how the report supports your claim aside from the small Japanese gelatin studies?
"badly phrased general paragraph in a general chapter."
That is an unambiguous and absolutely clear conclusion statement. They did not say "may induce", they said "do induce". They had ABSOLUTELY no doubts.
As I wrote before, their conclusion was based on ALL the vaccine literature from the 1950s, including the gelatin studies. I cannot tell you what were ALL the specific studies that informed this conclusion. I have found several of them myself and they are listed or referred here:
http://www.protocol-online.org/forums/topic/35639-professional-miscondu…
So nothing in the subsequent chapters you can point to? Not one case?
pg. 306/277:
"Gelatin, both whole bovine and hydrolyzed gelatin, was used as a stabilizer in a number of vaccines in Japan, and it is likely that children experiencing anaphylactic reactions to the gelatin-containing varicella vaccine had developed IgE sensitization to gelatin from the administration of previous
vaccines. "
As the committee points out, ALL injected proteins can cause allergy. I have provided you with numerous references to influenza HA sensitization, HepA sensitization, viral/bacterial/parasitic protein sensitization, toxoid sensitization, bee venom sensitization, ovalbumin sensitization as well as gelatin sensitization.
So besides the small scale, problematic Japanese studies the report has no cases. No evidence the IOM referred to that anything but gelatin in vaccines causes allergies, rather than triggers an allergic reaction, and the evidence on that is, well, weak.
I don't see how you can use a report that says it will refer to the cases in subsequent chapters and only addressed one type of substance as supporting your case that vaccines cause other allergies. It's pretty clear to me the general paragraph was simply not well written. Trying to use it to claim the report supports your general claim when the report has no such evidence is simply wrong.
The IOM report does not claim vaccines cause food allergies the way you are trying to and does not support you.
"So besides the small scale, problematic Japanese studies"
Who are you to characterize the quality of the studies?
You know more than the IOM about study quality?
How do you know ALL the evidence that went into drafting that paragraph?
"It's pretty clear to me the general paragraph was simply not well written."
May be you are looking for legalese?
Scientifically, that paragraph is absolutely clear and unambiguous. It leaves no doubt at all what the committee meant.
I didn't see the IOM offer a strong endorsement of those studies, either. Would you like to point to where they did?
A paragraph in the general section that referred to subsequent chapters as showing something is clearly drawing its meaning from what those chapters show. They don't show anything about most of the names proteins. Unless you can show that the report addressed them, you can't use that paragraph - which, again, clearly refers to what is shown in subsequent chapters - to support anything about them.
Taking that paragraph out of the context of the report is using it beyond its meaning. The IOM report does not support your claims.
Again, this is not a legal document.
Scientifically, it is perfectly clear.
Explain this:
Allergic reactions after egg-free recombinant influenza vaccine: reports to the US Vaccine Adverse Event Reporting System.
Yes, people can have allergic reactions to vaccines. Even if we ignore the fact that unverified VAERS report don't show amything besides the fact that someone filed a report, these reports don't show a vaccine caused an allergy.
I understand, from the scientists here, science actually does depend on evidence. Not on taking statements out of the context of the evidence.
"science actually does depend on evidence."
Yes, but you are unable to recognize the evidence. That's the problem.
There's another basic aspect of science. If you don't agree with an explanation for a phenomenon, YOU ARE EXPECTED TO PROVIDE A *BETTER* EXPLANATION. Can you?
" a vaccine caused an allergy."
A vaccine causing an allergy takes a few weeks. With doctors/allergists being ignorant about sensitization, vaccine package inserts OMITTING this information, no one reports it to the VAERS. A vicious cycle of incompetence continues to sicken our children.
"science actually does depend on evidence. "
Yes, let's see what you did with evidence from another part of the IOM report:
https://www.regulations.gov/docket?D=HRSA-2015-0003
This is what the NPRM said:
"1. The scientific evidence favors a rejection of a causal relationship between MMR vaccine and autism."
This is what YOU claimed the NPRM said:
https://www.regulations.gov/document?D=HRSA-2015-0003-0015
"as noted in the NPRM, the evidence supports
rejection of a connection between vaccines and autism."
Conveniently GENERALIZED MMR vaccine ALONE in the NPRM to ALL vaccines in your statement.
That's how you deal with evidence.
"I didn't see the IOM offer a strong endorsement of those studies, either. Would you like to point to where they did?"
The very fact that they refer to those studies at all meant that they were significant.
"When people admit they don't know, then they are admitting they are no longer experts."
I am bedazzled by the sheer and utter brilliance of this observation.
True, there are some who recognize limits of knowledge and are not ready to assign causes for phenomena in the absence of evidence. But they are simpletons! Real experts always have a facile explanation because it's, like, totally obvious if you follow the money and connect-the-dots.
"recognize limits of knowledge and are not ready to assign causes for phenomena"
Yes, like the vaccine "experts" who are clueless about the Flumist failure. They don't know why it works, how it works or why it fails. But they will go around telling you that the "benefits of the vaccine outweigh the risks", when they don't anything about the benefits or the risks.
It took the FDA 17 years to figure out that the acellular pertussis vaccine does NOT prevent disease transmission. They just ASSUMED it would prevent transmission.
It does not confer mucosal immunity. So people are colonized by pertussis bacteria and spread it. Worse, such colonization increases risk of multiple sclerosis. Who accounted for all these risks?
Again here ACIP ASSUMED that a meningococcal vaccine administered at 11 will be effective at 21. WRONG AGAIN.
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6003a3.htm
"The goal of the 2005 ACIP meningococcal immunization recommendations was to protect persons aged 16 through 21 years, when meningococcal disease rates peak. At that time, vaccination was recommended at age 11 or 12 years rather than at age 14 or 15 years because 1) more persons have preventive-care visits at age 11 or 12 years, 2) adding this vaccine at the 11 or 12 year-old visit would strengthen the pre-adolescent vaccination platform, and 3) the vaccine was expected to protect adolescents through the entire period of increased risk. Meningococcal conjugate vaccines were licensed in 2005 based on immunogenicity (because a surrogate of protection had been defined) and safety data. After licensure, additional data on bactericidal antibody persistence, trends in meningococcal disease epidemiology in the United States, and VE have indicated many adolescents might not be protected for more than 5 years. Therefore, persons immunized at age 11 or 12 years might have decreased protective immunity by ages 16 through 21 years, when their risk for disease is greatest."
IT IS OBVIOUS THAT THESE JOKERS DO NOT RECOGNIZE THE LIMITS OF THEIR KNOWLEDGE.
They are NOT experts and they are fooling with your children's lives.
@Wizrd1 #69
some people can have a severe reaction to even sterile saline injection.
If one is talking about the prefilled 'flush' vials then there is plenty of volatile organic compounds which leeched in from the plastic. I should think that this might trigger an 'allergic' response in some people. It bothers me that technicians will chide that what one is tasting/smelling is merely NaCl -- I had a powerful anxiety attack and blood pressure drop precipitated by knowing the glue taste I was experiencing was not 'only salt water' as the technician vehemently insisted that it was.
Becton Dickinson showed that the presence of volatile substances in the plastic material of the syringes was discovered in 2001 and that these substances were linked to the experience of minor reactions like bad taste or smell... The identification and saline-solution concentrations provided by Becton Dickinson were: 2-methyl-2-propanol: 8.5 ppm; 2-methyl-2-butanol: 0.7 ppm; ethyl-buthyl-ether: 0.4 ppm.
...have you ever heard of the arrow of time?
People assume that time is a strict progression of cause to effect, but *actually* from a non-linear, non-subjective viewpoint - it's more like a big ball of wibbly wobbly... time-y wimey... stuff.
-The Doctor, 1969 (or 2007)
Hey, the new XMAS special is tomorrow, and I'm a little excited about that.
By Johnny (not verified) on 24 Dec 2016 #permalink
That one kind of got away on him. :)
The definition of irony.
OK, it's illustration, not defintion.
Progress, arrow of time etc.,
"O'Brien et al. [13] measured 7.4 mcg/ml of ovalbumin in
influenza vaccines in 1967. Goldis et al. [14] measured as much as 38.3 mcg/ml in influenza vaccines as recently as 2008."
OTOH, it does demonstrate that as time progresses, we forget history, Dr.Richet's history.
Yes, like the vaccine "experts" who are clueless about the Flumist failure. They don't know why it works, how it works or why it fails.
No, Vinu. This has already been provided, but you likely overlooked from the cups of your tedious monomania.
Among the many problems* with your fantastically stupid IgE notion is that the problem is only with the A(H1N1)pdm09 component. It's remained more effective for B/Yamagata, dipshіt.
* Including the fυcking time frame.
"the problem is only with the A(H1N1)pdm09 component. It's remained more effective for B/Yamagata, "
A(H1N1)pdm09 component was in the formulation for several years before the 2014/2015 season, allowing people to develop strong IgE levels to it. B/Yamagata was not.
That would explain why A(H1N1)pdm09 would have the problem and not B/Yamagata.
"This has already been provided"
Yes, I saw that. My point was, if they were experts, they should have understood ALL this stuff BEFORE even approving the vaccine. Not after finding out that it was an abject failure.
^ Add "(PMID 27702768)" after "dipshіt," sorry.
My point was, if they were experts, they should have understood ALL this stuff BEFORE even approving the vaccine. Not after finding out that it was an abject failure.
Quick, Vinu, when was FluMist approved?
You don't need to be sensitized by Flumist for subsequent Flumist to fail.
Previous injected vaccines can induce IgE that can result in subsequent Flumist failure.
Repeated injection influenza failure:
http://cid.oxfordjournals.org/content/early/2014/09/29/cid.ciu680.full
It's a huge ONGOING disaster.
You lose. Try to figure out what B/Yamagata denotes next time.
If they are called Phuket, Massachusetts, Brisbane, Wisconsin, I suspect they are different ...
@Vinu
I'd prefer to see some epidemiological evidence on this issue, especially concerning the type of allergic reaction and how incident each type is.
Also, I can't help myself:
http://www.naturalnews.com/055457_vaccines_food_allergies_CDC_study.html
You've been referred to as an "expert in immunology" by our friends at Natural News.
By Ben (not verified) on 24 Dec 2016 #permalink
"some epidemiological evidence"
Please see #50.
"allergic reaction"
We are NOT talking about reaction to a vaccine (which are rare), we are talking about sensitization by a vaccine (development of a new allergy), which is much more common.
"expert in immunology"
Food allergy "experts" don't know what causes food allergy.
Autism "experts" don't know what causes autism.
Vaccine "experts" don't know how vaccines work.
So perhaps that's not way off ...
In reply to by Ben (not verified)
It's presumptive to dismiss the pertinence of epidemiological studies the way you did in #50, and also ignorant of how these sorts of studies are done. You realize vaccinated vs. unvaccinated studies have already been done for developmental disorders like autism, right? They're not unethical to perform, nor have they been routinely dismissed out of hand for small sample size.
You misunderstand: when I say "type of allergic reaction," I'm referring to the presentation of the induced food allergy I.e. is it characterized by hives, anaphylaxis, etc.
So when an expert doesn't know something that's not in evidence, they're no longer qualified as an expert. Good to know.
"It's presumptive to dismiss the pertinence of epidemiological studies "
As I wrote before, ignoring Dr.Richet's warning and injecting our children with food protein contaminated vaccines (without thorough research AND understanding FIRST) is unconscionable. Epidemiological studies would be justified if this were some COMPLETELY new problem. Not something that has been known for over a hundred years.
"So when an expert doesn't know something that's not in evidence, they're no longer qualified as an expert. "
No, in this particular case, we are talking about "experts" who were warned AND IGNORED the findings of the man who coined the very term "anaphylaxis". That is arrogance, stupidity, incompetence all rolled into one.
My understanding is that epidemiological studies look at whether a problem does, in fact, exist. Dr. Richet suggested a theory a long time ago. Studies looked to see whether the problem exists for vaccines and found that it didn't.
Dismissing and ignoring these studies doesn't make them go away.
"Dr. Richet suggested a theory a long time ago."
Are you kidding? Repeatedly demonstrating the induction of allergy and subsequent fatal anaphylaxis in multiple animals by multiple researchers, is NOT "a theory".
How do they induce food allergy in mice today if it is just "a theory"?
Since you are the know-it-all, why don't you explain what is causing the food allergy epidemic?
We have proof from numerous studies I have provided that proteins in vaccines cause sensitization. These results agree with Dr.Richet's findings. The results agree with the IOM's findings. So it is obvious that those isolated studies you are talking about are broken.
And explain this:
The above study is also proof that those epidemiological studies with all kinds of confounding factors are a joke. The vaccine "surveillance system" is a joke.
The team above performed a simple very well controlled experiment with JUST TWO KIDS. Measure IgE before and after vaccines. The results were IMMEDIATELY OBVIOUS as to the cause. The stupid surveillance system missed it even though millions developed food allergy.
You provided isolated case studies that you think support your claims. I'm afraid those are the isolated incidents, not the large scale epidemiological studies you are trying to dismiss.
The very rare case studies do not support a claim that vaccines are causing an epidemic of food allergies. The IOM, even in the paragraph you are trying to build on, certainly said nothing of the sort. And certainly did not point to any evidence on that. I expect the authors would be very surprised at what you're trying to turn the report into.
I'm afraid that you have no case.
"isolated case studies"
What is an isolated case study?
"very rare case studies "
What is a very rare case study?
"The IOM, even in the paragraph you are trying to build on, certainly said nothing of the sort."
If you cannot understand it, does not mean the IOM did not say it.
Dr. Richet's "warning" came, what, 100 years ago? I.e. While medical science was in its infancy? I.e. When control of infectious diseases were of paramount importance? Who exactly are you holding responsible here, the experts who were more concerned with decreasing the infant mortality rate than the unverified possibility of an increase in persistent food allergies?
You're putting the cart before the horse. Your hypothesis has never been tested on the population-level (to my knowledge). I'm no immunologist and can't speak to whether or not the proposed mechanism if plausible, but if it is I doubt many would be opposed to exploring a possible association if no epidemiological research has been done before.
A study with two children is not going to demonstrate causation, especially when those two children were selected for their food allergy beforehand. You've clearly been doing a lot of hobby reading on immunology, now spend some time on epi.
No, scientists were certainly not opposed to examining this. Studies were done. This review is older, and other studies were done since, but it makes the point that the question was certainly not ignored.
http://pediatrics.aappublications.org/content/111/3/653
No link was found between vaccines and food allergies.
Let's look at this:
The only reference to food allergy is this study:
Background of the study:
"Pertussis vaccination in infancy has been suggested to increase the risk for development of asthma and allergy."
So, they were NOT EVEN looking to investigate the RIGHT PROBLEM!
We know ALL vaccines are contaminated with various food proteins, not just the pertussis vaccine.
"placebo [diphtheria and tetanus toxoids]"
Oops! The placebo itself is another food protein contaminated vaccine! What results can you expect?
During this study, the children likely received numerous other food protein contaminated childhood vaccines per the schedule. Nothing is controlled.
This is a massive joke!
AND, the IOM already took this study into account (1950-2011 literature was covered) but still concluded that food protein contaminated vaccines DO induce food allergies.
"When control of infectious diseases were of paramount importance?"
If we have a raging epidemic killing people, a quickly created, food protein contaminated vaccine that saves lives is perfectly understandable. We have had DECADES to clean up vaccines and NOTHING has been done.
Dr.Offit himself, a top vaccine advocate, has said that the regulators and pharmaceutical companies are NOT interested in cleaning up our contaminated vaccines and called for consumer activism.
http://www.pbs.org/wgbh/frontline/article/paul-offit-a-choice-not-to-ge…
"Yeah. I think there are a couple things. The influenza vaccine and the yellow fever vaccine are both made in eggs; therefore they contain small quantities or residual quantities of egg proteins. About a half a percent of the population is allergic to eggs, including severe allergies, including things such as bad hives and shock, and those people can't get influenza vaccine. Well, there's no reason you can't grow influenza vaccine in mammalian cells, meaning non-avian cells. That can be done. The technology has been available to do that for decades, but there's been little interest in doing that. It cries out for, in many ways, consumer activism.
Similarly, there's a stabilizing agent that's used in the chicken pox vaccine called gelatin. It allows the vaccine virus to be distributed equally throughout the vial. The question is, are there other stabilizing agents that you could use, that aren't gelatin, that could accomplish the same thing? Absolutely. But again there's [been] very little pressure, I think, to do that, even though it's probably the most common allergenic material in vaccines."
"Your hypothesis"
Sorry, when the IOM agrees with Dr.Richet's findings, it is certainly NOT a hypothesis any more and certainly not "my hypothesis".
"A study with two children is not going to demonstrate causation, especially when those two children were selected for their food allergy beforehand."
A study EVEN with only children has proven valuable because it is so well controlled. Cause and effect were immediately obvious. And this is just the LATEST, not the only study. I have provided numerous references.
If they are called Phuket, Massachusetts, Brisbane, Wisconsin, I suspect they are different …
Congratulations. You have just accidentally demonstrated that you were making things up when you said this:
The kicker, of course, is that you're trying to weasel away from your actual assertion (emphasis added):
When you receive Flumist the first time, you develop IgG (short term, primary protection against the flu) and IgE (long term allergy) to the influenza proteins.
When you receive subsequent Flumist, you suffer a mild allergic reaction. Your IgE antibodies bind to the viruses and neutralizes them before they can infect you. So you don't develop new IgG. Vaccine is ineffective.
Long Term Persistence of IgE Anti-Influenza Virus Antibodies in Pediatric and Adult Serum Post Vaccination with Influenza Virus Vaccine
http://www.medsci.org/v08p0239.htm
The reference I provided already showed IgE sensitization by BOTH Flumist and injected vaccines. What are you complaining about?
You don't need to be sensitized by Flumist for subsequent Flumist to fail.
Would you care to answer the question rather than barfing up a non sequitur?
The reference I provided already showed IgE sensitization by BOTH Flumist and injected vaccines.
Not in any sense that you're trying to use it for. Moreover, you've now contradicted yourself, since your boneheaded idea should apply to IIV as well as the LAIV that you used as a springboard for this faceplant (not to mention that the magic IgE that "causes" LAIV failure should in fact have a protective effect against wild influenza, as the authors directly state).
What are you complaining about?
Your tediously repetitive, low-rent attention whoring, Vinu.
" (not to mention that the magic IgE that "causes" LAIV failure should in fact have a protective effect against wild influenza, as the authors directly state)."
Either IgE has a protective effect (long term 20 months) and so the CDC is wrong about needing annual flu shots, or the IgE protection is not as good as desired. IgE is likely first line of defense and you need both IgE+IgG for full protection.
Wow, you really don't understand anything about the influenza vaccine, do you?
Each year, the most likely strains of influenza that are anticipated to spread are selected and a vaccine is created against those strains, such as a trivalent vaccine (three strains) or quadravalent vaccine (four strains).
As influenza mutates rather rapidly, those strains will be quite different each year and last year's vaccine won't be effective against this year's strains.
"those strains will be quite different each year and last year's vaccine "
Repeated since 2012-13
A/California/7/2009 (H1N1)pdm09[note 1]-like virus
B/Brisbane/60/2008-like virus
https://en.wikipedia.org/wiki/Historical_annual_reformulations_of_the_i…
That is why it stops working.
AND, they test the vaccine in a third world country where there is no routine seasonal influenza vaccine. So the tests go very well and the vaccines fail in the US.
It's a disaster.
Uh huh, so the identified new strains listed don't exist in your Bizarro world, huh?
Pity that here on earth, they do exist and mutate quite often.
As for third world, do enlighten us where that alleged testing occurs? I've heard of old world, new world and developing nations, who would lack the infrastructure to test a vaccine.
So, citation needed. I'll wait. Until proton decay, if necessary.
As for "So the tests go very well and the vaccines fail in the US.", again, citation needed and I know damned right well that you'll fail to find a citation for that, as it's a bald faced lie.
Efficacy is around 30% - 65%, depending upon what one is looking for (hospitalization, pneumonia, etc).
http://annals.org/aim/article/709081/efficacy-influenza-vaccine-elderly…
Although, I'm quite certain that we'll now here from the nirvana fallacy.
Oh, for antigenic shift: http://jamanetwork.com/journals/jama/article-abstract/374844
Here's another that discusses various strains. The city name isn't where the vaccine was tested, it's where the virus sample was acquired.
http://www.sciencedirect.com/science/article/pii/S0264410X96003027
"third world"
http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedPr…
"Current- and previous-season vaccination generated similar levels of protection, and vaccine-induced protection was greatest for individuals not vaccinated during the prior 5 years. "
You are truly pathetic. I called it early yesterday when I mentioned that you'd jump into the nirvana fallacy with both feet.
You dove into it.
Oddly, none of the documents that you presented mentions the "third world", meanwhile, when you present the same document twice, quoting one phrase out of the entire document twice, you gain precisely zero points.
If you don't know what third world means, please look it up. It is not that difficult ...
The proper term is "developing nations", not third world, which is an insult to all developing nations.
Apparently, you can't take a gentleman's hint.
Ah, forgot about political correctness police ...
"who would lack the infrastructure to test a vaccine."
I am not talking about infrastructure. I am talking about a population that gets routine influenza vaccination (US) vs. one that does not (third world). Repeated vaccination affects efficacy.
"new strains"
Basically, the vaccine is 50% useless, out of the gate.
I get the feeling that you have taken advantage of the holiday season, knowing that I wasn't paying much attention to the comments. That assumption was partially correct. It is correct no more. I tire of your nonsense.
What nonsense?
"I tire of your nonsense."
You seem to be getting increasingly delusional, Vinu. I'm not leaving this killfile off forever.
Both the trivalent and quadrivalent influenza vaccines are formulated differently for the 2016-17 flu season compared to a year ago.
"For the vaccine for the northern hemisphere's influenza season that will begin in the fall of 2016, WHO recently recommended including the A/California/7/2009 (H1N1)pdm09-like virus, A/Hong Kong/4801/2014 (H3N2)-like virus, and B/Brisbane/60/2008-like virus (B/Victoria lineage), with the addition of B/Phuket/3073/2013-like virus (B/Yamagata lineage), for the quadrivalent vaccine"...
"The H3N2 strain and the B strain will be new for the US and northern hemisphere 2016-2017 trivalent vaccine. In 2015-2016, the trivalent vaccine included A/California/7/2009 (H1N1)pdm09-like virus, the A/Switzerland/9715293/2013 (H3N2)-like virus, and the B/Phuket/3073/2013-like virus. The quadrivalent vaccine included B/Brisbane/60/2008-like virus."
http://www.medscape.com/viewarticle/859922
Flu vaccine does not "stop working" because experts repeatedly select the same strains for the vaccine. It is more or less effective depending on how well vaccine strains match the ones causing infection. If similar strains circulate from year to year, it makes sense to keep including them in multivalent vaccines.
This is elementary immunology/vaccine science.
Well, there is a bit of luck in predicting which strain is most probable for global spread. Once in a while, that turns into a dice roll and we end up with much less effective vaccine.
Most of the time, that doesn't happen.
BTW, I do quite like the strain names, as they describe the specific virus very accurately. Of course, I also have my virus name decoder ring sitting on the nightstand... ;)
Seriously though, it does actually accurately describe characteristics and lineage of the virus of interest.
@vinu, a hint, an H1N1 or H3N2 virus isn't the only characteristics of an influenza virus, there are other antigens that the immune system "tags" as well and even those two variants are very different. There are literally hundreds of variants in the world, some which won't even infect a human.
But, you'd have to have a grasp of fundamental biochemistry, cellular receptors and nearly 101 level virology. To judge from the entirety of your commentaries, you lack all of the above.
"Flu vaccine does not "stop working" because experts repeatedly select the same strains for the vaccine."
"Current- and previous-season vaccination generated similar levels of protection, and vaccine-induced protection was greatest for individuals not vaccinated during the prior 5 years. "
"IT IS OBVIOUS THAT THESE JOKERS DO NOT RECOGNIZE THE LIMITS OF THEIR KNOWLEDGE.
They are NOT experts and they are fooling with your children's lives."
This applies more to you than them.
By Jay (not verified) on 25 Dec 2016 #permalink
Jay @ 133, at least I know the limitations on my knowledge. My knowledge of biochemistry is nearly 101 level, however the concepts are known well enough and I can reliably figure out various major groups of chemicals and their general behavior (although, I'm far better with drug families, such as macrolides, etc).
What receptors are, do and how they're generally structured is well enough understood.
How a virus enters into a cell and replicates is decently well enough understood at the arm length level.
But then, we see the spectacular examples of Dunning - Kruger...
All of my knowledge grants me one "superpower", knowing when my protocol list results in DOCTOR NOW.
That fine skill resulted in physicians trusting me a great deal with many drugs and even treatments, which they rarely trusted other SF medics with. Knowing when you've departed your depth, critically important. Knowing that you're reaching that point, priceless.*
*Many years ago, our unit surgeon suggested that I pack the ACLS drug kit, with the notion that morphine would be available for certain specific service members who had angina and hence, had a higher probability that they'd suffer an MI and require pain control.
All well and good, however, our treatment set lacked an ECG. Deliver morphine under the wrong conductive pathway condition, one might as well have simply shot the patient, they'd end up equally dead.
I explained that and my hesitancy toward carrying those chemicals in such a vacuum, as the majority of the drugs would be useless, for the same reason, but add accounting for expiration date, breakage, etc.
In the end, the only time I carried morphine was in combat and ACLS drugs, never. They stayed on the air ambulance, which wasn't mine. But, there was one thing on that air ambulance that I cared about more - they carried blood. That innovation saved a *lot* of lives!
~A man's got to know his own limitations. - A fictional character in a lousy movie
Food protein contaminated vaccines are sickening our kids with life-threatening food allergies.
You have the Flumist flip-flop.
For the flu vaccine to work, you must be unvaccinated for 5 years.
Do you ever tire of such nonsense?
By brian (not verified) on 25 Dec 2016 #permalink
"healthcare workers who received a single AS03-adjuvanted H1N1pdm09"
Inapplicable in the US. We did not have an adjuvanted H1N1 vaccine.
In reply to by brian (not verified)
"CONCLUSIONS:
This study provides the immunological evidence-base for continuing annual influenza vaccination in adults."
BTW, Orac is our host. Your response to his objection was entirely inappropriate and frankly, I wonder as to the quality of your upbringing.
This study provides the immunological evidence-base for continuing annual influenza vaccination in adults."
Enough said."
Unfortunately, coming to inappropriate conclusions like this one, is pretty common.
I see that Vinu is still at it. I don't know what I did recently to deserve the "honor" of his return, but now I am really tiring of his nonsense. Clearly, he took advantage of my being around the blog much less than usual due to Christmas Eve and Christmas. Even though I took a day off today producing new material and will not be posting as often as usual again until after New Years, I am back and I am around. There will be posts, and if Vinu continues to make up something like half the comments I see coming through my e-mail notifications, I might well have to put him into automatic moderate.
Normally, I have a very light to nonexistent touch moderating, as long time readers know, but it is possible to annoy me enough to be banned or placed in automatic moderation.
"if Vinu continues to make up something like half the comments"
Oh, so you hate the VOLUME of comments, not the facts provided. At least that's good to know ...
Orac,
"I am really tiring of his nonsense"
"it is possible to annoy me enough to be banned or placed in automatic moderation."
I take your threat of censorship as proof that you are unable to scientifically challenge anything I have posted.
You've been repeatedly refuted right in these comments, you pretend that the refutation doesn't exist, just as you pretend that papers say what they actually do not say.
Hint: Cherry picking a phrase from one article, then stitching it together from another paper's cherry picked phrase isn't evidence.
Inventing things from whole cloth also isn't evidence, it's invention and fabrication.
Calling something trash, when you're speaking of a vaccine is also not evidence.
Refutation? Not even close.
I demolished the food allergy part of Dr.Offit's paper that Dorit posted.
Oh, so you hate the VOLUME of comments, not the facts provided.
You're not so much presenting facts, it's more like presenting cherry-picked, out of context factoids, that don't support your point.
You claim that vaccines *cause* allergies, and the only real evidence you have is some guy 100 years ago said so.
"You claim that vaccines *cause* allergies, and the only real evidence you have is some guy 100 years ago said so."
Good to know that you accept that it is indeed REAL EVIDENCE.
But you forgot that the IOM report which agrees with Dr.Richet, is only 5 years old ...
Thank you, Orac. Vinu is also just so boring by persevering on allergies and someone's century old work.
Stop using electricity, it's many centuries old ...
Vinu writes (#151),
Oh, so you hate the VOLUME of comments, not the facts provided. At least that's good to know …
You're a great presence Vinu, please consider throwing a quick knockout punch and then prepare for the next fight. Also, stop punching them when they're down - it's poor sportsmanship.
By Michael J. Dochniak (not verified) on 26 Dec 2016 #permalink
In reply to by Michael J. Dochniak (not verified)
Sadly, in vinu there is not veritas.
And he can't even hew consistently to that.
DB...you win the Internetz today.
"But you forgot that the IOM report which agrees with Dr.Richet, is only 5 years old "
Does the IOM also agree with the existence of Ectoplasm?
Some boring person: "Stop using electricity, it's many centuries old …"
Lame, very lame. You have obviously not kept up with production, transmission and storage technology even in the last few years.
Vinu clearly didn't listen to my warning. Automatic moderation on.
"The team above performed a simple very well controlled experiment with JUST TWO KIDS"
Is it me, or is this one of the stupidest sentences of the year?
A "well controlled experiment", where n=2 and there is no control group?
Why did they stop there, why not push the boat out and do some more blood tests a month later, a year later, etc?
Hey, maybe these levels go up and down irrespective of vaccinations?
Food allergy after vacciination is coincidence.
Autism after vacciination is coincidence.
Kawasaki disease after vacciination is coincidence.
Specific IgE going up after vaccination is coincidence.
Specific IgE goes up and down, but going up somehow coincides with vaccination, correct?
It will be a lot easier, if you pay attention to the underlying scientific mechanism.
Does bees sting allergy go up and down randomly with no relation to bee stings? Why does it affect beekeepers? COINCIDENCE! What else can it be?!
Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis
Seriously, Kawasaki disease?
One of the rarest diseases on the planet is your primary "points"?!
Seriously, in that instance, I could be drunk, intoxicated with opioids and kicked in the head by a horse and still discard your idiocy.
Cherry picking a phrase out of multiple articles, as you've repeatedly done doesn't earn respect, it earns hard won disrespect and distrust.
Here, lemme help you a bit. I actually do know of this disease and hence, find your claim laughable.
"Kawasaki disease affects boys more than girls, with people of Asian ethnicity, particularly Japanese and Korean people, most susceptible, as well as people of Afro-Caribbean ethnicity. The disease was rare in Caucasians until the last few decades, and incidence rates fluctuate from country to country.
Currently, Kawasaki disease is the most commonly diagnosed pediatric vasculitis in the world. By far, the highest incidence of Kawasaki disease occurs in Japan, with the most recent study placing the attack rate at 218.6 per 100,000 children <5 years of age (about one in 450 children). At this present attack rate, more than one in 150 children in Japan will develop Kawasaki disease during their lifetimes.
However, its incidence in the United States is increasing. Kawasaki disease is predominantly a disease of young children, with 80% of patients younger than five years of age. About 2,000-4,000 cases are identified in the U.S. each year (9 to 19 per 100,000 children younger than 5 years of age)."
Well, rare, specific ethnic groups tend to have higher rates, zip on anything that you claim and even money, it'll be eventually discovered to be a point or three mutation.
Real, yes. Persuading, not so much.
But you forgot that the IOM report which agrees with Dr.Richet, is only 5 years old.
That's an example of cherry-picked, out of context factoids.
And that's all you (and MJD) got.
"Real, yes. Persuading, not so much."
Thanks for letting us know that REAL EVIDENCE DOES NOT PERSUADE you. Makes all your other comments understandable.
I didn't notice Vinu was on auto-moderation until after I posted above, and calling him out like that is unsportsmanlike. My bad.
Also, using the word 'factoid' isn't really correct in this case. Please substitute 'passages'.
If he responds, I'll let his response through.
Your hand is not that light, Orac. I recieved no warning before being placed on automatic moderation over the pharma-shill sensitive subject of Kratom.
And you just shadow ban without warning also.
Poor baby. If you don't like it, no one's forcing you to stick around.
"Among subjects with symptom onset
within 42 days of vaccination (days 12, 25, 29), 3/12049 [0.02%, 95% CI: (0.01% ,
0.07%)] MENVEO recipients and 0/2877 [0%, 95% CI: (0%, 0.13%)] control
recipients were diagnosed with Kawasaki Disease. "
(bolding mine) -
Among subjects with symptom onset within 42 days of vaccination (days 12, 25, 29), 3/12049 [0.02%, 95% CI: (0.01% , 0.07%)] MENVEO recipients and 0/2877 [0%, 95% CI: (0%, 0.13%)] control recipients were diagnosed with Kawasaki Disease.
3 out of 12,049.
On the subject of odds (and nothing else) I note that according to http://www.lightningsafety.noaa.gov/odds.shtml
thats about the same as being struck by lightning in your entire life.
http://www.nmaus.org/disease-prevention-information/statistics-and-dise…
Assume meningococcal vaccine coverage is 80% in the US for teens.
Assume vaccine is 100% effective.
There are ~200 cases of bacterial meningococal disease per year in teens.
Number of teens in the US, ~40 million.
Risk of meningococcal disease in an unvaccinated teen is 40,000,000*0.2/200=40000 or 1:40000.
The risk over a 5 year period (vaccine effectiveness period) is 1:8000.
So we are being asked to choose between a 1:8000 chance of getting bacterial meningitis vs. 1:4000 risk of Kawasaki disease.
Laughably, I habituated myself with assisting commo in setting up their antenna.
With annoying frequency, thunderstorms rolled in while we were attempting to do so.
Oddly, despite a near unity risk exposure, none of us were struck by lightning.
Just as the overwhelming majority of the populace never suffered the claimed allergies or other claimed deleterious effects.
MJD @160
If Vinu had tried this sort of stunt in an under-grad seminar when I was at university in the '70s he would have been torn several new ones...He has yet to come up with a sustainable argument supported by consistent, repeatable, verifiable, falsifiable evidence.
By Murmur (not verified) on 26 Dec 2016 #permalink
"He has yet to come up with a sustainable argument supported by consistent, repeatable, verifiable, falsifiable evidence."
The HHS hired the IOM to do the job of finding the RELEVANT evidence. The IOM concluded with ABSOLUTELY no doubts at all that food protein contaminated vaccines cause the development of food allergies.
Your job is to provide COUNTER EVIDENCE. Not one person has provided ANY evidence that stood up to scrutiny.
In reply to by Murmur (not verified)
Vinu, can you - with your superior grasp of statistics - calculate what is the probability that the rate for Kawasaki disease is the same for both vaccinated and control, and by mere luck none of the 2877 controls were the "one in four thousand"?
It's also nice to see you give due reverence to the role of vaccines in upholding herd immunity.
By gaist (not verified) on 27 Dec 2016 #permalink
"Vinu, can you – with your superior grasp of statistics – calculate what is the probability that the rate for Kawasaki disease is the same for both vaccinated and control, and by mere luck none of the 2877 controls were the "one in four thousand"?"
Oh, yes, COINCIDENCE again!
Natural sepsis due to meningococcal bacterial infection can cause Kawasaki disease. So it is not some fantastic coincidence.
It IS the stupid vaccine. Molecular mimicry resulting in autoimmune disease.
H1N1 infection caused narcolepsy. The H1N1 vaccine Pandemrix also caused narcolepsy. Same problem here with Kawasaki disease.
http://stm.sciencemag.org/content/7/294/294ra105
And this molecular mimicry is not limited to N meningitidis alone. So guess what's causing this ONCE RARE disease to become not so rare any more?
In reply to by gaist (not verified)
Sorry about the formatting ...
Method used:
Kawasaki results:
Well, now I'm all confused about this horrible upsurge in Kawasaki disease in the United States. Except there isn't one.
"Analysis of the (Kids Inpatient Database) and other hospitalization databases revealed no clear evidence for a statistically significant increase in the incidence of KD in the United States for over 2 decades. In contrast, for reasons that are not well understood, a steady increase in KD incidence has been reported in many other countries, including Japan."
Antivaxers are fond of telling us that a horrific expansion of the U.S. vaccine schedule over that time period is responsible for increases in all manner of diseases in children. It must be a "fantastic coincidence" that Kawasaki disease hasn't found a place on that laundry list.
Probably the IOM, CDC, FDA, CIA and TVA are suppressing the data. :(
I see that Smith et al. proposed a much more compelling explanation than Vinu's completely idiotic one for the effect of repeated vaccination on influenza VE 16 years ago.
"16 years ago"
After 16 years, we have the Flumist fiasco.
And for injected influenza vaccines to be effective, you have to unvaccinated for the previous 5 years.
Either Smith et al. are wrong or the vaccine establishment is incapable of learning from Smith et al. Which one is it?
On the page Vinu cites at (currently) 180, I read "Of those who get meningococcal disease 10-15 percent die."
At http://www.merckmanuals.com/professional/pediatrics/miscellaneous-disor… I read "Without therapy, mortality may approach 1%, usually occurring within 6 wk of onset. With adequate therapy, the mortality rate in the US is 0.17%".
So, Vinu, using your own numbers, assuming all cases of Kawasaki disease are untreated, how many deaths does meningococcal vaccine prevent?
Again from the same page you cite, I read "Among those who survive, approximately 1 in 5 live with permanent disabilities, such as brain damage, hearing loss, loss of kidney function or limb amputations". What percent of Kawasaki patients suffer permanent disabilities?
"What percent of Kawasaki patients suffer permanent disabilities?"
Discovered in 1976. Who knows what the long term impacts are?
Look at the basic science. The risk of bacterial meningitis is 1:8000. Assume ALL of them develop sepsis. In that case, sometimes, the immune system creates autoantibodies because of molecular mimicry between N meningitidis and human proteins. The result is KD. With vaccination that involves injection of N meningitidis proteins, that 8000 factor is gone. So we just increased KD risk 8000X!
And as posted in #186, looking at protein sequence alignment, it is not just N meningitidis but many other vaccine antigens can cause the same problem.
Vaccines are a very important tool for health. But poorly designed vaccines and their abuse, is extremely dangerous as well.
Did Vinu just pull the exact same argument that RFK Jr. made against that particular vaccine?
By Lawrence (not verified) on 27 Dec 2016 #permalink
Vinu: The IOM concluded with ABSOLUTELY no doubts at all that food protein contaminated vaccines cause the development of food allergies.
NO, THEY DID NOT!! I've just had a read, Vinu's quote comes from the beginning of the document discussing food antigens in vaccines. See below the true conclusion of the IOM:
"Anaphylactic reactions to several vaccines are likely caused by the presence of components introduced during manufacturing, such as egg protein, milk protein, or gelatin. When a specific inciting component of the vaccine has been identified and the manufacturers find ways to remove or drastically reduce the amount of the reactive antigen (e.g., egg protein in influenza vaccine), the number of reports of anaphylaxis in spontaneous reporting systems has decreased . It appears likely to the committee that the risk of anaphylaxis caused by vaccines is exceedingly low in the general population. The risk is obviously higher in people with known and demonstrably severe allergies to certain vaccine components, such as eggs or gelatin."
You are confusing TWO separate aspects.
Sensitization: Development of a new allergy in a non-allergic person.
Elicitation:Allergic reaction (including anaphylaxis) caused by allergen exposure in a person who is already allergic to the substance.
The paragraph I quoted makes it ABSOLUTELY CLEAR that food protein contaminated vaccines cause sensitization (development of new allergy).
You are quoting elicitation related material.
See this section for more interesting information:
"Sensitization needs less injected allergen than elicitation"
No Vinu, I'm not, the only reason for that paragraph you quoted is in the context of the one I quoted.
They are talking about removing amounts of reactive antigens to decrease the incidence of anaphylaxis. Not vaccines causing food allergies.
Anybody else feel free to read the concluding comments on page 629. Or allow me to sum up:
1) Slight causal link between MMR and Febrile seizures. No long term sequelae.
2) Varicella vaccine contraindicated in those with severe immunodeficiency.
3) Evidence supports the association of anaphylaxis with certain vaccines in certain circumstances. Removing reactive antigens decrease anaphylaxis rates. the risk of anaphylaxis caused by vaccines is exceedingly low in the general population. The risk is obviously higher in people with known and demonstrably severe allergies to certain vaccine components, such as eggs or gelatin.
What you quoted says nothing about sensitization.
We are talking about sensitization.
So it is not directly relevant, except as I pointed out with "Sensitization needs less injected allergen than elicitation" ...
Whoops forgot link:
https://www.nap.edu/read/13164/chapter/15
I'm going out on a limb, and guessing that Vinu's favorite sport is dodgeball.
I'll ask again -
Using your own numbers, assuming all cases of Kawasaki disease are untreated, how many deaths does meningococcal vaccine prevent?
What percent of Kawasaki patients suffer permanent disabilities?
Your honesty is on display here. Got any?
Johnny @ 197, I consider vinu (sic) and the dodging, gish galloping and assorted cherry picking, then arrived long ago as to my opinion of the level of gravitas and honor possessed by the troll.
Hence, my decision not to feed the trolls, save if the goat is poisoned.
As trolls are infamously refractive to poisons, I await my resupply of effective poisons for that troll. Fortunately, part of the poison has arrived, via moderation.
That said, the morbidity and mortality rate for Kawasaki disease varies, depending upon one's origin, Japan or the rest of the world. That suggests a founder effect for that island.
It's still rather low, only higher in Japan.
Which is something vinu will likely dodge and dance around, then likely, gish gallop and cherry pick, as usual.
Wasting everyone's time.*
*After the fifth time someone's been called and proved a BS'er, it's time to stop wasting time. It only gives free advertisement, to be cherry picked and copypasta'd elsewhere as a "victory" point, even if the point was entirely disproved.
Waste of time, waste of food, oxygen and germ line cells to create such a creature.
Excellent poster child for barrier contraception though, "Don't let your progeny come out like this! Contraception is the key!".
Your questions demonstrate you are missing the point again.
The vaccine MUST BE SAFE ENOUGH that I should not have to worry about ANY OF THIS NONSENSE.
"But I think they should be, because I think that when you give things to healthy children, they should meet really the highest standards of safety testing."
THIS is the highest standards of safety in 2016?
In the same article Dr.Offit says:
"And of the million children then that got that vaccine, about 100 developed this intussusception, which is to say, one per 10,000. One child died from that vaccine. And it was immediately taken off the market. But it shows you, I think, how quickly and well we were able to respond to an unanticipated side effect. And again, even though the vaccine was tested in 10,000 children pre-licensure, you weren't going to be able to detect an event that occurred in 1 per 10,000 children. "
Here we have 1 in 4000 developing KD PRE-LICENSURE, why did the vaccine get on the market at all? Where is the honesty in the safety claims?
Vinu "What you quoted says nothing about sensitization."
Great! I agree! That IOM report concludes nothing about sensitization.
You should retract that paper of yours keep linking to, now that you know you were in error.
Seriously, I think the IOM would be quite horrified at the use you put that out of context quote.
Sensitization conclusion with all the required context is right here for anyone who does not twist facts.
Vinu "Your questions demonstrate you are missing the point again.
The vaccine MUST BE SAFE ENOUGH that I should not have to worry about ANY OF THIS NONSENSE."
Thorny questions dodged; check. Goal post moved; check. All this done shamelessly; check. ;)
Let me guess again - Your favorite band is Nirvana.
All medical interventions that have an effect, can also have side effects. This, of course, includes vaccines. Sometimes, these side effects can be serious, and they can be long lasting, and they can be fatal. Medical science should continue to work to develope medical intervention with fewer and less sevier side effects.
Nobody, and especially me, disagrees with this. If this is your point, then we are in violent agreement.
Now, answer the questions I asked, and I'll add another - do you think MENVEO should be used until something better comes along?
"All medical interventions that have an effect, can also have side effects. This, of course, includes vaccines. "
No. As Dr. Offit said, VACCINES MUST BE HELD TO A HIGHER STANDARD. They are administered to healthy people unlike other interventions.
"do you think MENVEO should be used until something better comes along"
When is this coming along? How many decades does it take?
The new Men B vaccine is EVEN WORSE than the Men ACWY that they don't even recommend it for routine use.
KD due to meningococcal sepsis was known in 2009.
So why was MENVEO approved without fixing this problem?
All of this points to one fundamental problem. There is no incentive to make safe vaccines. The SYSTEM IS TOTALLY BROKEN.
Why don't you trust crash tests performed by the automakers? We have independent government crash tests and EVEN BETTER, we have IIHS crash test ratings. That is what we need for vaccines. Ratings. So people can choose and REJECT poor quality vaccines.
Instead, we have this socialized medicine nonsense where we are supposed to believe that ALL vaccines are somehow created equally safe and effective.
Menactra was approved in 2005.
MENVEO in 2010. So it is not as if there was no vaccine available. This shows new vaccines are approved with the same old problems.
From year 2000:
So BOTH vaccine makers failed to do their homework by checking their vaccine antigens for KD risk.
If people are not able to choose the better vaccine, why would vaccine makers invest in a better vaccine design? Out of the goodness of their hearts? This is Soviet style medicine with Soviet quality results.
Narad,
How do you explain this:
"Administraton of Menactra one month after DAPTACEL has
been shown to reduce meningococcal antibody responses to Menactra" ?
Menactra is a Diphtheria Toxoid (DT) Conjugate Vaccine. So, if you have high DT antibody response from the DAPTACEL, it blocks Menactra, reducing meningococcal antibody responses.
Menactra
Got it. Vaccines must be perfect, or they must not be.
Wzrd1 had it right.
[singing]
Mamas don't let your babies grow up to be Vinu...
[/singing]
Sorry. I'll stop now.
vinu: "Vaccines are a very important tool for public health."
vinu: "There is no incentive to make safe vaccines. The SYSTEM IS TOTALLY BROKEN."
He sounds like RFK Jr. and his collaborators in "Thimerosal: Let The Science Speak" - who acknowledge on the one hand that vaccines have saved many lives, while fervently denouncing them and everyone connected with their development and promotion as corrupt liars.
No, those who play this game are not antivaccine. Why do you ask?
"Sensitization conclusion with all the required context is right here for anyone who does not twist facts."
It is clear you don't know the meaning and the use of the word "conclusion" AND that you haven't read the report you are quoting, which is about Anaphylaxis. The quote is talking about the general properties of allergens and you are using it incorrectly.
Please see below a link to a list of conclusions of that report (a handy pointer here, it has the word conclusions in the title)
http://www.nationalacademies.org/hmd/~/media/Files/Report%20Files/2011/…
By Jay (not verified) on 03 Jan 2017 #permalink
Now the big question that should be asked here is, what did the IOM conclude about food allergies caused by vaccines?
Well there's quite a bit of literature to wade through, so I'll cherry pick for a change and just use the latest, as it would be most up to date:
"The committee's review did not reveal an evidence base
suggesting that the U.S. childhood immunization schedule is linked to autoimmune diseases, asthma, hypersensitivity , seizures, child developmental disorders, learning or developmental disorders, or attention deficit or disruptive disorders."
http://nationalacademies.org/hmd/~/media/Files/Report%20Files/2013/Chil…
Well that's a relief! Though to be fair to Vinu, they are keeping an eye on the issue. Did read that one committee stated that there was weak evidence to a biological mechanism (in 2004), so it's not implausible.
The title of the paragraph you quoted is:
"No Evidence of Safety Concerns "
"No evidence"? Really? Even top vaccine advocates would not make such a ridiculous claim. Seizures are associated with injuries on the vaccine injury table. How can they deny vaccines causing seizures?
THIS IOM committee and its report seem like a great example of vaccine associated scientific fraud. Given the egregious claims above, you cannot believe anything they say. They should be investigated for professional misconduct.
By vinu arumugham (not verified) on 03 Jan 2017 #permalink
"Though to be fair to Vinu, they are keeping an eye on the issue. Did read that one committee stated that there was weak evidence to a biological mechanism (in 2004), so it's not implausible."
Now that you have discovered it for yourself, why don't you give the IOM 2011 sensitization statement and the following results, an unbiased look? Does it not strengthen the evidence from 2004?
wao.confex.com/wao/2015symp/webprogram/Paper9336.html
"A committee of experts convened by the Institute of Medicine to review the scientific literature on possible adverse effects of vaccines found convincing evidence of 14 health outcomes -- including seizures, inflammation of the brain, and fainting -- that can be caused by certain vaccines, although these outcomes occur rarely."
http://nationalacademies.org/hmd/reports/2011/adverse-effects-of-vaccin…
"no evidence of safety concerns"?
I thought we'd determined in a previous thread that vinu is afraid of needles and therefore would prefer that everyone suffer VPDs than have to get a single shot, and is just using a misunderstanding of "allergy" as a smokescreen?
By JustaTech (not verified) on 03 Jan 2017 #permalink
"misunderstanding of "allergy""
What's the misunderstanding?
Yeah it's frustrating that he's so blind to anything that does not interest him, I've been doing some more reading on vaccine history. Fascinating stuff, people were really desperate, arm to arm vaccination, reports of vaccines having thousands of bacteria in them and of course the discovery that "dirty" vaccines work better, leading to the development of adjuvants.
Vaccines have come a long way.
""dirty" vaccines work better, leading to the development of adjuvants."
What does "work better" mean? Well, the vaccine produced a stronger immune response to a smaller vaccine antigen dose.
That's of course great for disease protection.
Now consider what happens to tiny amounts of contaminating proteins in the vaccine. They too ENJOY the stronger immune response. Result, an allergy epidemic. But that's a dirty secret, nobody wants to talk about ...
Platts-Mills TAE. The allergy epidemics: 1870-2010. Journal of Allergy and Clinical Immunology. 2015. p. 3–13.
"Vaccines have come a long way."
Sometimes, it's several steps back before a step forward ...
" O'Brien et al. [13] measured 7.4 mcg/ml of ovalbumin in
influenza vaccines in 1967. Goldis et al. [14] measured as much as 38.3 mcg/ml in influenza vaccines as recently as 2008. "
Unfortunately vinu's days here appear to be numbered.
Yet another crank brought down by the relentlessness of human inventiveness. . .
By Opus (not verified) on 04 Jan 2017 #permalink
yep, so inventive, even the link does not work ...
In reply to by Opus (not verified)
And, borked the punchline
Goodness vinu @217, what haven't you misunderstood about allergies? I've strongly recommended a good textbook on the subject that discusses both vaccines and allergy (Janeway's Immunobiology, 7th edition or newer).
So, a few things you've missed: the different types of allergy and the cells that mediate those allergic responses. The mechanism by which allergic responses come to occur. the mechanisms by which allergic responses can stop happening. How the adaptive immune system works (the memory part of the immune system). The various immunoglobulins and their production and mechanisms of action.
Like MJD, with whom you share an unsupported theory and frustrating posting style, you are so totally fixated that you failed to learn the necessary background to actually make a contribution.
Yar, watch Vinu turn on his previously untouchable authority. That was predictable. In fact, I have loads more quotes saved up, but I'm on my phone in swanky hotel learning about VOIP. So gonna have to wait till Thursday Evening UK time ;)
"the different types of allergy"
We are talking about Type I IgE mediated hypersensitivity. Why do you bring up other irrelevant types of allergy?
Why don't YOU tell us exactly what this means:
"... the
Perhaps another "American Loon" candidate?
By Lawrence (not verified) on 04 Jan 2017 #permalink
So, a few things you've missed: the different types of allergy and the cells that mediate those allergic responses. The mechanism by which allergic responses come to occur. the mechanisms by which allergic responses can stop happening. How the adaptive immune system works (the memory part of the immune system). The various immunoglobulins and their production and mechanisms of action.
I don't think anything you said is wrong, but the way I read the tea leaves, you missed the big thing.
Vinu seems to think that anything that causes an allergic reaction is the same as causing an allergy. For example, while the flu vaccine can cause an allergic reaction in someone allergic to eggs, Vinu seems to think that reaction is the allergy, and not a symptom/result of the allergy. Vinu's words say that food proteins in vaccines cause people to become allergic, but the citations (other than some 100 year old musings of a long dead guy) are all of people having allergic reactions.
By Johnny (not verified) on 04 Jan 2017 #permalink
Unfortunately that is a complete mischaracterization of my posts.
In #194, I clearly explained the difference between sensitization and elicitation.
"For example, while the flu vaccine can cause an allergic reaction in someone allergic to eggs, Vinu seems to think that reaction is the allergy, and not a symptom/result of the allergy."
You have to understand that non-allergic people who get a flu shot can get sensitized to egg in the vaccine, in about three weeks time after the shot (develop a new allergy). They will have no symptoms, no reactions whatsoever. The next flu shot, they can suffer an allergic reaction.
If the IOM were only talking about reactions/anaphylaxis, you would be right. But as I have repeatedly pointed out, the IOM said, "do occasionally induce sensitization ...". Sensitization means DEVELOPMENT OF A NEW ALLERGY, not an allergic reaction due to an existing allergy.
Vinu @229: Let us say for the sake of argument that a single flu shot caused a person to develop an egg allergy. What is the probability that said person will not encounter egg protein again for a full year, before their next flu shot?
And what is the probability that this person had never been exposed to egg proteins before?
The average American, even one who eats a thoughtful and nutritious diet, will encounter more egg products than they think. Unless you are actively avoiding eggs because of dietary choices, or because you already have intolerance or allergy, then you will eat some egg between flu shots, to which you would have a reaction. Your statement is highly improbable.
But let's get to the bigger question: what do you want? You have stated your hypothesis. Now state your desired next actions, assuming that the data support your hypothesis.
Of course, once sensitized by egg in a flu shot, you can have a reaction to eating egg as well. In fact, this is the most common case we are discussing. People being sensitized by food protein contaminated vaccines, developing food allergies and being unable to eat those foods anymore.
"And what is the probability that this person had never been exposed to egg proteins before?"
By what route of exposure?
Eating allergen builds tolerance.
Injecting allergen causes sensitization.
"Now state your desired next actions"
What do you logically expect? REMOVE ALL FOOD PROTEINS FROM ALL VACCINES.
Removal of gelatin from live vaccines and DTaP—an ultimate solution for vaccine-related gelatin allergy
"A guinea pig can be sensitized by intramuscular injection of an antigen, say OVA (ovalbumin). Its immune system responds by producing antibody to OVA, including (but not
exclusively) IgE. Some of this circulating IgE will be fixed onto mast cells in various tissues, including the vasculature and respiratory tract. Three weeks later, the same animal can be
challenged either with an intravenous dose of OVA or by exposure to an aerosol containing OVA. Following IV injection, the animal will rapidly develop severe vascular shock and die within a few minutes (the combination of venule constriction and capillary dilation results in pooling of blood in the peripheral circulation and a drastic drop in blood pressure). If exposed to the aerosol, it will equally rapidly die from bronchial constriction, an experimental model for human asthma. "
Food allergy and asthma after intramuscular injection of food protein. What are the most common childhood diseases today, again? Food allergy and asthma. Another FANTASTIC coincidence, correct? At this rate, I think COINCIDENCE can be documented as a known vaccine adverse event.
I'd like to see documentation for the statement that food allergy and asthma are "the most common childhood diseases today". Aren't colds, ear infections, eczema etc. a wee bit more common?
But vinu will probably be allergic to backing this claim up too.
By Dangerous Bacon (not verified) on 06 Jan 2017 #permalink
Aren't colds, ear infections, eczema etc. a wee bit more common?
You mean like this?
By Narad (not verified) on 06 Jan 2017 #permalink
In case you've ever wondered HOW vine does it:
https://youtu.be/ykGuOIMGbLI
I had absolutely no idea that it was such a team effort - I've always had an image of our valiant keyboard warrior working alone.
Damn autocorrect!!
vinu @231:
Reply the first. You said "Injecting allergen causes sensitization."
But what about allergy shots, which are injections that build tolerance?
Reply the second: You said " REMOVE ALL FOOD PROTEINS FROM ALL VACCINES."
OK. We are currently facing a nasty strain of influenza this year, that's already killed 9 people in my county. Can you, by next fall, have an egg-free flu vaccine in quantities that are sufficient to protect the whole country, that has passed all regulatory hurdles?
Or are we just supposed to not have a flu shot for however long it takes to develop a new manufacturing process?
"Reply the first. You said "Injecting allergen causes sensitization."
Yes, that causes IgE mediated sensitization.
But what about allergy shots, which are injections that build tolerance?"
Once you are sensitized and have IgE mediated allergy, further injection of SMALL quantities of allergens causes IgG4 induced tolerance. This is better than anaphylaxis but it is a poor substitute for natural tolerance to foods acquired through eating them. IgG4 induced tolerance can cause GI diseases such as eosinophilic esophagitis (EoE).
"OK. We are currently facing a nasty strain of influenza this year, that's already killed 9 people in my county. Can you, by next fall, have an egg-free flu vaccine in quantities that are sufficient to protect the whole country, that has passed all regulatory hurdles?"
You have had a 100 years (since Richet) to fix this problem and you make up this artificial false constraint?
"Or are we just supposed to not have a flu shot for however long it takes to develop a new manufacturing process?"
1. Due to repeated influenza vaccinations, your new flu vaccine may not work.
2. As in #232, you will develop IgE to HA proteins. When you inhale HA proteins, you can develop asthma.
Something to consider before the next flu shot, EVEN if it is free of all other proteins.
for years, the American Academy of Pediatrics (AAP) advised pregnant women with peanut allergies to stop eating peanuts while pregnant and to not feed peanuts to their children when they started on solid foods.
That changed in recent years, when two major studies proved that advice wrong. In one, the rate of peanut allergies was about 10 times lower for children who ate peanuts from an early age, compared to kids whose parents avoided giving their infants peanuts.
http://time.com/4622667/how-to-prevent-peanut-allergy/
That being said, vinu's assertion that peanut products being injected and combined with adjuvants to kick off an immune response which might include sensitization to the food stuffs seems a bit plausible to me.
By Gilbert (not verified) on 06 Jan 2017 #permalink
Gilbert, well, yeah, that could happen, but what evidence is there that there are peanut proteins in vaccines? It's not like everyone doesn't know that peanuts are a common allergen.
Like, if I injected someone with peanut protein and, say, LPS, which is a hell of an adjuvant, I would not be at all surprised if they developed a peanut allergy. No one's disputing that. I'm just asking for evidence that there is peanut protein in vaccines. I can't think of any reason to introduce it into the manufacturing process.
"Like, if I injected someone with peanut protein and, say, LPS, which is a hell of an adjuvant, I would not be at all surprised if they developed a peanut allergy. No one's disputing that."
Ok, then you do agree that vaccines can definitely cause egg, milk, soy, yeast, etc. allergies because they are documented contaminants. We don't have LPS, but we do have aluminum salts which are pretty good Th2 biasing adjuvants.
"Peanut"
There are two possibiliities:
1. As in #70, peanut oil is used in injectable products.
Since it is approved as an injectable, it can contaminant any other injectable product including vaccines due to shared manufacturing equipment ANYWHERE in the process.
2. https://www.researchgate.net/publication/310021910_Significant_protein_…
In a society bounded by the joke of prohibition, JustaTech, I'd just assume that pharma puts it in there for shits and giggles.
And thus, ignoring the Libertarian, in a heavily regulated environment that is heavily risk adverse, aversion of doing so?
That's quite a fascinating view.
By Wzrd1 (not verified) on 06 Jan 2017 #permalink
Right I'm back. Sort off, laptop battery died. Can't get at my quotes or those IOM reports.
"Now that you have discovered it for yourself, why don't you give the IOM 2011 sensitization statement and the following results, an unbiased look? Does it not strengthen the evidence from 2004?"
I bounced around all three, you are the one with the bias here. It is plain for everyone to see. You don't even read the documents and you are seemingly deliberately miss quoting them. Plausible mechanism does not equal "it happens" and also does not give a frequency.
That was 2004.
In 2011 they didn't even look at food allergies...
They were examining Anaphylaxis, which are really rare and can be made rarer by removing food allergies. Happy days.
2013 Catagorically states there are no safety concerns about vaccines causing hypersensitivity.
Great, so let's all agree, we should work to removing food allergens from vaccines to cut the rate of Anaphylaxis.
Then, when that's sorted, we can tease Vinu unmercifully when there is no change in food allergy rate ;)
"Plausible mechanism does not equal "it happens" and also does not give a frequency."
"do occasionally induce IgE-mediated sensitization "
means IT HAPPENS, not just plausible.
So you have no answer for my argument, that the IOM states that vaccines don't cause food allergies? Didn't think so.
The IOM 2012 report said vaccines DO cause the development of food allergies.
I proved to you that the IOM 2013 report YOU QUOTED is a FRAUD. They listed vaccines as not causing seizure. Seizure causing adverse events are on the vaccine injury table.
The 2013 report is a joke that should be thrown out.
You are asking a lot here. The IOM states that antigens may cause sensitisation, you missread that as vaccines cause food allergies and the IOM is an untouchable authority.
The IOM clearly states that vaccines don't not cause food allergies and now you say the IOM are frauds.
Who do you think will be convinced by this?
"The IOM states that antigens may cause sensitisation, you missread that as vaccines cause food allergies and the IOM is an untouchable authority."
IOM 2012 report said:
"Antigens in the vaccines", "do occasionally induce sensitization". Anyone with even basic knowledge of immunology knows, that means vaccines cause food allergy.
"The IOM clearly states that vaccines don't not cause food allergies and now you say the IOM are frauds."
The IOM 2012 committee is DIFFERENT from the 2013 committee. The 2013 committee/report is easily demonstrated to be a fraud.
"Anyone with even basic knowledge of immunology knows, that means vaccines cause food allergy."
Which leaves you out of any such group, as you have zero clue about immunology.
"The IOM 2012 committee is DIFFERENT from the 2013 committee. The 2013 committee/report is easily demonstrated to be a fraud."
Odd, so the committee is different because some members replaced other members? That invalidates all knowledge, education and experience? Why, my local hospital is an entirely different hospital at each shift change, who knew?!
As for the "committee/report" being easily demonstrated to be a fraud, it's a terrible shame that you've entirely been incapable of proving that.
I'm totally down with Narad, why put nickles into the jukebox when all of the records are broken?
"Which leaves you out of any such group, as you have zero clue about immunology."
And who are you to make that determination?
"Odd, so the committee is different because some members replaced other members? That invalidates all knowledge, education and experience? "
No, it changes the balance of corrupt vs. non-corrupt members.
"As for the "committee/report" being easily demonstrated to be a fraud, it's a terrible shame that you've entirely been incapable of proving that."
Why did they claim vaccines do not cause seizures, when adverse events that include seizures are on the vaccine injury table?
"And who are you to make that determination?"
I'm someone who seems to know a great deal more than you about immunology, as most of the things that you've said are either incorrect, impossible or plain nonsense.
"No, it changes the balance of corrupt vs. non-corrupt members."
So, you are telepathic and read their minds to find corruption? Evidence of corruption? No, an assumption of corruption, as the committee had findings that differ from your inept understanding of immunology and vaccines.
"Why did they claim vaccines do not cause seizures, when adverse events that include seizures are on the vaccine injury table?"
The only way that that committee could be held responsible for what is on the table is if they had created the table. Congress created the table via an Act of Congress. If having two heads was on the table, would you then expect people to grow an other head when vaccinated? Congress has historically fouled up technology and medicine laws.
" Congress created the table via an Act of Congress."
The injuries on the table are determined by the Secretary on the advice of the ACCV and scientific evidence.
https://www.hrsa.gov/advisorycommittees/childhoodvaccines/Meetings/2016…
"The National Childhood Vaccine Injury Act of 1986 (Act), as
amended, authorizes the Secretary to create and modify a
list of injuries, disabilities, illnesses, conditions, and deaths
(and their associated time frames) associated with each
category of vaccines included on the Vaccine Injury Table."
So either the HRSA is using pseudoscience on the table or the 2013 IOM claim is pseudoscience.
IOM 2011 looked at ACTUAL EVIDENCE and said, pg.132/162
"Conclusion 4.4: The evidence convincingly supports a causal rela-
tionship between MMR vaccine and febrile seizures."
Your 2013 report says:
"Experts who addressed the committee pointed not to a body of evidence that had been overlooked but rather to the fact that existing research has not been designed to test the entire immunization schedule."
They had NO evidence about the safety of the entire immunization schedule (which is what they were charged to assess), so they just made it up.
As usual Vinu twists the truth. I cant duoble check at the loment, I'm in a carpark. The 2013 report does say it's one of the most comprehensive review of the entire schedule done to date...
Also yon 2011 report states that only "some" vacines cause seizures, maybe those aren't included in the 2013 schedule?
By the ways, who still does the MMR jab. Here in the UK we use a 5 in 1 jab.
"Also yon 2011 report states that only "some" vacines cause seizures, maybe those aren't included in the 2013 schedule?"
The MMR causes seizures and it is on the 2013 schedule.
There's no escape ...
"The 2013 report does say it's one of the most comprehensive review of the entire schedule done to date…"
2013 report:
"existing research has not been designed to test the entire immunization schedule."
When there is no evidence, a comprehensive review should be quick and easy.
Oh wait, the plot thickens:
2013 paper abstract:
"As reviewed by prior Institute of Medicine studies, a substantial literature exists on adverse effects of individual vaccines, but few studies have focused on elements of or the recommended childhood immunization schedule as a whole. The lack of conclusive evidence linking adverse events to multiple immunizations or other "schedule" exposures suggests that the recommended schedule is safe. "
Lack of evidence means exactly what it says. You cannot jump to ANY conclusion. Are vaccines safe? We JUST DON'T KNOW. The research is not there.
https://www.hrsa.gov/vaccinecompensation/resources/adverseeffects.pdf
" (135 vaccine-adverse event
pairs), the evidence is inadequate to accept or reject
a causal relationship. "
"made rarer by removing food allergies. Happy days."
Bloody spellchecker. That was meant to say "removing food allergens " of course.
The Israeli studies that have led to the AAP-etc's change in recommendations about when to introduce peanuts suggest that vinu has it all backwards.
https://www.washingtonpost.com/news/to-your-health/wp/2017/01/05/new-ni…
Were there any peanut proteins in the vaccines give to young infants, they would have help protect against developing the allergies.
Summary including original research references here (no, my bad, I haven't read all the source material but posting it anyway):
By Chemmomo (not verified) on 06 Jan 2017 #permalink
"Were there any peanut proteins in the vaccines give to young infants, they would have help protect against developing the allergies."
Sorry, you have misunderstood. Young infants have to EAT peanut to get protection. If you inject peanut protein, they develop peanut allergy. At a high level, eating induces immune tolerance.
Injecting induces allergy.
@Chemmomo, oddly, the US also had introduced similar research.
It's good to have research confirmed, replication and all.
Let's review the engineering problem; child develops within a nearly sterile womb, receives limited antigens from immune compromised via pregnancy mom.
Upon delivery, child hopefully receives colostrum from mom, loaded full of antibodies, if not, child has to have a heavier load of "learning" of the immune system and has a significant disadvantage under primitive situations.
Child is then flooded by exposures with antigens, many will be upon skin that child occasionally finds and gradually finds his or her mouth. The rest are largely airway borne.
Both antigen sets meet in the upper thorax, where the thymus is and a *lot* of immune system attention is focused during development and development isn't finished, the child is half-baked, far from adult, indeed, far from a nymph stage.
All of that was expressed from less than a half second of consideration of the argument.
I could add hundreds of supporting citations and arguments, but the troll will never desist, as a paid asset never will fail to seek pay.
(insert your own cultural term of greeting, salutation and departure, I'm tired and have to go to work in the morning)
If there wasn't some fundamental difference between eating and injecting as a route to gen up an immune response then we'd all be eating Cornflakes and Cherrios fortified with MMR and folic acid.
The FDA is too stupid to understand this fundamental concept.
They think injecting proteins is the same as ingesting proteins.
http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/VaccineSaf…
"Why are sugars, amino acids, and proteins added to some vaccines?
These substances may be added as stabilizers. They help protect the vaccine from adverse conditions such as the freeze-drying process, for those vaccines that are freeze dried. Stabilizers added to vaccines include: sugars such as sucrose and lactose, amino acids such as glycine or the monosodium salt of glutamic acid and proteins such as human serum albumin or gelatin. Sugars, amino acids and proteins are not unique to vaccines and are encountered in everyday life in the diet and are components that are in the body naturally."
Cobra venom is a protein that can be safely eaten if you don't suffer from ulcers. So, per the FDA protein in vaccine rules, cobra venom is approved for use in vaccines. As per the geniuses at the FDA, If you can eat it, it is safe to inject.
The food allergy epidemic is the result when you put a monumentally incompetent agency like the FDA in charge of vaccine safety.
What a wonderful idiot who denigrates the hard work of thousands who, without appropriate staffing or budgets,most I'll manage to track and improve the safety of hundreds, if not thousands of different products.
"Who manage..."
Work is in progress on a vaccine against peanut allergies:
http://allergenbureau.net/melbourne-group-to-fast-track-peanut-allergy-…
Hopefully, tandem research will be able to prevent antivaxers' heads from exploding.
Humans seem to ALWAYS underestimate the difficulty of fooling nature.
Vaccines are about fooling the immune system into providing immunity without suffering the disease. With our unsophisticated vaccines, we have achieved disease protection at the cost of creating chronic life-threatening diseases (food allergy and asthma).
As I show here, food protein epitopes cross react with bacterial epitopes.
Now if this peanut allergy vaccine makes you tolerant to peanut proteins, as a side effect, it could also make you to tolerant to bacterial proteins that look similar. In other words, the body will assume these bacterial proteins are safe and not attack those bacteria any more. So basically, you could lose the protection to vaccine preventable diseases that you had gained via vaccines. Putting you back to square one. Oops!
For a start I'm not clicking on any more of your "research", you are not a scientist, your assertations carry out weight, your conclusion flawed, biased, blinkered and nonsensical.
Allow me to demonstrate:
"as a side effect, it could also make you to tolerant to bacterial proteins that look similar."
Citation needed lol.
Even if it did, we would not be back to square one as this would only be given to those who had food allergies, the population would still be vaxed, therefore there would be herd immunity.
Again you are trying to create a scare over nothing. Fuxk off.
"Citation needed lol."
The researchers admit they understand very little of what's going on.
So the citation you are looking for is here:
https://en.wikipedia.org/wiki/Murphy's_law
Captain Murphy was an incurable optimist. ;)
"herd immunity."
The latest guidance is now for early childhood exposure to peanuts.
After much study, where previously it was advised to avoid peanuts early in life, in order to avoid peanut allergy, that thinking is now believed to be in error.
Like John Kerry's:
"I actually did vote for the $87 billion before I voted against it."
Flumist flip/flop.
The AHA/ADA flip/flop on dental premedication.
And now the peanuts flip/flop.
When these groping-in-the-dark "experts" claim vaccines are safe, most people swallow it hook line and sinker, and all the way to the elbow ...
Ah! So, now pediatric immunologists are vaccine developers and investigators, right?
A change in evidence in a distantly related field discredits all fields of science in your nirvana fallacy suffering world.
Well, EMS and emergency department procedures have changed over the years as well, don't trust them if you have a severe accident.
Go to your local butcher shop instead.
"Ah! So, now pediatric immunologists are vaccine developers and investigators, right?
A change in evidence in a distantly related field discredits all fields of science in your nirvana fallacy suffering world."
No. It demonstrates a pattern. They ignore the warning of a doctor from a hundred years. They ignore what they were taught in medical school. They ignore common sense because they are the "experts". They mess it up royally. And then they flip/flop. Again and again. Add corruption to the mix. That makes a great recipe for the disaster that is being served up now.
"They ignore the warning of a doctor from a hundred years."
Yes, they also stopped bleeding people for influenza. That was the cause of George Washington's death. They also stopped sticking unsterilized fingers into gunshot wounds, like they did with Abraham Lincoln and William McKinley.
"They ignore what they were taught in medical school."
Thank goodness that they do! Knowledge advances, new understandings emerge. Oncologists rarely cured many cancers, even during my early life. Today, many, many cancer patients are successfully treated, moving from remission to cure. All because physicians advanced our understanding of cancer and created new treatments, rather than sticking only with what they were originally taught.
Or do you want us to go back to the days when TB was a death sentence, cancer also a death sentence and female hysteria was thought to be a real thing?
"And then they flip/flop."
Yeah, doctors were trained that stress and diet caused stomach ulcers, then some upstart collected bacterial samples from patients with ulcers. Now, medicine has "flip-flopped" and treat those ulcers with proton pump inhibitors and antibiotics, curing them. How dastardly of them!
"Add corruption to the mix."
Again and again you claim corruption, not a single time have you provided evidence of corruption, only a conspiracy theory and conspiracy theory laden websites.
"That makes a great recipe for the disaster that is being served up now."
The only disaster that is being served up now is your spew wasting electrons and electrical current.
Actually, that's not a disaster, it's an annoyance. You and your ilk having your way and preventing physicians from preventing communicable disease would be a disaster.
I've saw with my own eyes what polio and measles can do to those without access to vaccines and I've saw when both diseases struck vulnerable populations, filling many tiny graves. I'd just as soon not see those things in a nation I spent the better part of my life in military defense of. I still have nighmares from those experiences.
"Thank goodness that they do! Knowledge advances, new understandings emerge. "
The concept in the UCI class notes below from 2011 is identical to Dr.Richet's finding more than a hundred years ago. Now since you claim to be the immunology expert, please show us the EVIDENCE that these concepts are OUTDATED.
challenged either with an intravenous dose of OVA or by exposure to an aerosol containing OVA. Following IV injection, the animal will rapidly develop severe vascular shock and die within a few minutes (the combination of venule constriction and capillary dilation results in pooling of blood in the peripheral circulation and a drastic drop in blood pressure). If exposed to the aerosol, it will equally rapidly die from bronchial constriction, an experimental model for human asthma. "
"Yeah, doctors were trained that stress and diet caused stomach ulcers, then some upstart collected bacterial samples from patients with ulcers. Now, medicine has "flip-flopped" and treat those ulcers with proton pump inhibitors and antibiotics, curing them."
EXACTLY. Doctors should know that they can easily be WRONG as above. Happens all the time. So, they have to keep an open mind and look at the EVIDENCE carefully again and again. THEY CAN NEVER EVER CLAIM VACCINES ARE SAFE AND THE SCIENCE IS SETTLED. Because as you have shown, the science is NEVER EVER settled.
And if your stomach is a little unsettled after your "cure", it is because the science is not settled ...
Helicobacter pylori: enemy, commensal or, sometimes, friend?
" have you provided evidence of corruption"
Which planet do you live on?
http://tdi.dartmouth.edu/press/press-releases/corruption-of-the-health-…
https://www.nytimes.com/2014/11/19/opinion/how-medical-care-is-being-co…
Young infants have to EAT peanut to get protection. If you inject peanut protein, they develop peanut allergy. At a high level, eating induces immune tolerance.
And, once again, the halfwit who lies about being a medical student at Medscape demonstrates that TPN and blood transfusions are death sentences. There's no point feeding nickels into a jukebox full of broken records.
Hypersensitivity to total parenteral nutrition fat-emulsion component in an egg-allergic child.
It does not take 14 days to have a Type I reaction. The only explanation is that the egg containing IFE caused a new allergy or boosted a weak allergy.
TPN and blood transfusions are death sentences
Hmm. Those don't directly contain an adjuvant facilitating inflammation to give a 'heads up' for the collocated antigen. Total Parenteral Nutrition -- Inject a well-blended cheezeburger.
the child is half-baked
https://www.youtube.com/watch?v=Mkqmd0saSC4
Just to recap: vinu asserts that all vaccines are contaminated with food proteins. vinu asserts that these must and do cause the development of food allergies. (The number of additional people with allergies is no asserted or demonstrated.)
Therefore, to prevent the possible development of and unknown number of food allergies vinu demands that everyone everywhere stop using any injected vaccine until it has been shown to vinu's approval that it does not contain food proteins.
So that leaves us with only the vaccines we've already gotten (adults) and the oral polio vaccine, which is known to have serious side effects and is only used in places with high risk of polio and sub-optimal medical infrastructure.
So vinu: How many people have died of food allergies they have gotten from vaccination (and show that they did not develop these allergies naturally) and compare that to how many people will die of VPD's while we scramble to make your perfect vaccines.
"vinu demands that everyone everywhere stop using any injected vaccine until it has been shown to vinu's approval that it does not contain food proteins."
Thanks for putting a lot of words into my mouth.
Here's what I actually said:
" phasing out
food proteins from vaccines and injections as soon as possible would
be the real solution for food allergies caused by vaccines and injections"
"we should immediately stop multiple vaccines being administered
simultaneously. "
" we should add a warning in
vaccine package inserts about food allergy being a possible side effect. "
"we should add a warning in
vaccine package inserts about food allergy being a possible side effect. "
This is what I reckon is Vinu's true motivation, it's like Wakefield part two. Blame a condition that has evidentialy nothing to do with vaccines, on vaccines, to allow parents and lawyers to get rich suing presumably everyone involved.
IOM concludes food proteins in vaccines cause sensitization.
Dr. Richet said the same a hundred years ago.
UCI medical school notes say injectiing food proteins causes fatal food allergy and asthma.
I have numerous more scientifc references here:
NO ONE has provided any evidence to counter it.
Obviously, there is no place for science in this NON SCIENCE BLOGS.
Does not apply to tetanus, pertussis and may be others.
It took the FDA 17 years to figure out acellular pertussis vaccine does not prevent transmission. More flip/flops are possible ...
""herd immunity."
Does not apply to tetanus, pertussis and may be others."
Tetanus is not transmitted between people, so this statement is unusually ignorant even for vinu.
And it is untrue that herd immunity "does not apply" to pertussis. It's not sufficient to completely stop spread in highly vaccinated populations, but the more people are covered by vaccination, the less likely it is to infect susceptible persons.
vinu needs coursework in basic immunology and infectious disease, as well as help in developing critical thinking skills.
Fortunately, online assistance is available.
http://www.openculture.com/2014/02/oxfords-critical-reasoning-for-begin…
"It's not sufficient to completely stop spread in highly vaccinated populations, but the more people are covered by vaccination, the less likely it is to infect susceptible persons. "
Relevant evidence please.
Long term persistence of inflammation in children vaccinated with Salmonella conjugate vaccine is associated with augmented Th9-Th17 cytokine
E-mails as evidence, how quaint. With a bit of searching, I can find e-mails and use them evidence for flying saucers and reptilian invaders.
That doesn't make them real.
Those emails show that unlike the bogus experts here, the REAL immunology experts value my input.
Uh huh, a cool response, within a degree of absolute zero cool is not welcoming your input.
FWIW, I'll add a thought that has been occurring to me for a few days.
I would characterize Vinu's entire reasoning process as a combination of yeah-but-ism and what I would call the square zero fallacy.
That is, no matter how many times we refute his allergy speculations and point out that there is no link between vaccinations and allergies, he responds with "yeah, but what about this other mechanism that might possibly cause a problem".
And his comment that we can say nothing about the safety of vaccines is a perfect example of the square zero fallacy.
He wants to go back to square zero, ignore all the mountains of vaccine safety (and effectiveness) research from development testing to large scale population studies to follow-up surveillance and talk about possible problems with vaccines as if we knew none of that.
But in fact we know that vaccines (at least the officially approved ones) are extremely safe, that they have a few significant side effects occurring at about the 1 in 100,000 rate, that long term severe side effects only happen at a rate of 1 in a million or less, and that they are much, much safer than the diseases they protect against.
By squirrelelite (not verified) on 11 Jan 2017 #permalink
"how many times we refute"
You have not done it even once.
In reply to by squirrelelite (not verified)
We have loads, you are just to stupid/ mental to realise it.
I meant SCIENTIFIC REFUTATION.
But you don't understand the scientific Vinu, that's painfully obvious to everyone.
If you were serious, get at least a degree in a life science, learn the damn history. You wouldn't make the basic mistakes that earn you such ridicule.
Ref comment #258
Don't forget that vinu is also afflicted with the Nirvana fallacy, which allows him to claim that something does not exist (i.e. herd immunity protecting against pertussis infection) if it is not 100% perfect.
I found another course he should consider taking:
https://www.futurelearn.com/courses/logical-and-critical-thinking
"(i.e. herd immunity protecting against pertussis infection) if it is not 100% perfect."
Still waiting for the citation ...
I'm trying to imagine how people think that food proteins (other than chicken egg) get into vaccines, and I got the lovely mental image of a giant vat labeled "vaccines" and a worker on a catwalk dropping a sandwich into it.
It made me smile.
Naw, the worker on the catwalk over the vat of vaccines spilling a cup of soup, after dipping a PB&J sandwich into it.
"Butterfingers! That's the third time this week!"
No, actually food proteins get into our vaccines when pharma workers lose their footing on the catwalk and plunge into the boiling cauldron o'toxins, never to be seen again.*
*like in Upton Sinclair's "The Jungle", where slaughterhouse workers fell into the vat and went out into the world as Durham's Pure Leaf Lard.
"Mary had a little lamb And when she saw it sicken She shipped it off to Packingtown And now it's labeled chicken."
Yeah, that book was required reading when I was in school.
It no longer is, but I bought that and Nineteen eighty four for both of our kids.
Gosh. That must have hurt.
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