Researchers at Johns Hopkins have established a high-efficiency cell-cell fusion system, providing a new model to study how fusion works. The scientists showed that fusion between two cells is not equal and mutual as some assumed, but, rather, is initiated and driven by one of the fusion partners. The discovery, they say, could lead to improved treatments for muscular dystrophy, since muscle regeneration relies on cell fusion to make muscle fibers that contain hundreds or even thousands of nuclei.
Mouse model studies show that administered genetically or topically, protein Smad7 protects against or heals mouth sores commonly associated with cancer treatment. In some cancer patients treated with radiation, the mouth sores known as oral mucositis become so severe that feeding tubes are required for nutrition and narcotics are needed for pain. In fact, 40-70 percent of patients treated with upper-body radiation develop the condition to some degree.
Scientists have discovered that the ovary contains a group of cells similar to stem cells that can mutate to form tumors. In a study of mouse ovaries, they found they could coax the stem-like cells to become cancerous by switching off two tumor-suppressing genes. The study is likely to make a significant contribution to what we know about ovarian cancer.
Pathologists and clinical laboratory administrators should stay alert to the effect on the traditional role of pathology with increasingly effective, predictive clinical decision-support software. To support the transition to predictive healthcare — and in a move that is a separate but parallel initiative to its Watson healthcare program — IBM recently unveiled its new healthcare analytics software.
New research published in the Journal of Dental Research describes an advance in efforts to develop a method to replace missing teeth with new bioengineered teeth generated from a person's own gum cells. The research is led by professor Paul Sharpe, an expert in craniofacial development and stem cell biology at King's College London's Dental Institute.
Spring training is well under way!
We are anxiously awaiting Opening Day for our Birds here at the Yard in Baltimore on April 5. However, NSH has a number of Home Team Events to keep our focus over the next few months. The Carolina Symposium scheduled April 5-6 has a fantastic lineup of speakers guaranteed to hit a home run for you and your lab in Charlotte. So don't drop the ball; register today!
"Bright light city gonna set my soul, gonna set my soul on fire!" That's right we are at it again. The 6th Annual Summer Symposium will be hosted in the city where we break all the rules. Viva Las Vegas! Who says what happens in Vegas, stays in Vegas? The histology jackpot you bring home to the lab is sure to keep them talking for a very long time. So join the winners circle; register today!
"Just can't wait to get on the road again." The life we love is meeting with our friends. Yes, you heard it here, NSH is coming to a state meeting near you. Many of our state society friends have invited us back for the spring meeting season. Please be sure to visit our booth for some fun give aways, learn more about NSH, purchase a text book or just say "hello."
A signaling molecule that helps stem cells survive in the naturally low-oxygen environment inside the bone marrow may hold clues to helping the cells survive when the going gets worse with age and disease, researchers report. They hope the findings, reported in PLOS ONE, will result in better therapies to prevent bone loss in aging and enhance success of stem cell transplants for a wide variety of conditions from heart disease to cerebral palsy and cancer.
It's long been predicted that use of computer algorithms to sift through clinical data sets can be one way to detect disease. This is a diagnostic method that — in theory — could either increase or decrease the need to perform medical laboratory tests for certain types of diseases. A paper recently published by researchers in India describes an improved algorithm to detect thyroid disease by computer screening. The advancement could lead to earlier detection of subclinical thyroid problems and allow for earlier diagnosis and intervention.
BBSRC-funded researchers have developed a new strategy that can give scientists a better insight into how complex molecular machineries function in living cells. In research published in the journal Molecular Systems Biology, the team from the University of Warwick, Manchester Interdisciplinary Biocenter and Liverpool University, showed how to extract in vivo information about how complex molecular systems in yeast cells are controlled.
New research shows that a tiny piece of RNA has an essential role in ensuring that embryonic tissue segments form properly. The study, conducted in chicken embryos, determined that this piece of RNA regulates cyclical gene activity that defines the timing of the formation of tissue segments that later become muscle and vertebrae. Genes involved in this activity are turned on and off in an oscillating pattern that matches the formation of each tissue segment. If the timing of these genes' activity doesn't remain tightly regulated, the tissue either won't form at all or will form with defects.
Without eyes and ears, how does a cell know its position? One cell biologist found good design principles at work in the way cells learn about their environment for making decisions. Arthur D. Lander, of the Department of Developmental and Cell Biology, Department of Biomedical Engineering, and Center for Complex Biological Systems at the University of California-Irvine, wrote an intriguing article for Science about a road less traveled in microbiology.


- Do you plan on burning any discs with your new machine? If the answer is yes, do some research and find a burner that would suit you best. There isn't really much to explain here, except that trying to save money by buying a cheap burner is a bad idea. Pay attention to read/write speeds, and make sure you keep track of what you're buying. I've had several people ask me why their new CD burners don't work - come to find out, they accidently bought a DVD writer or a CD reader instead.
DEFINENTLY buy an internal CD burner, unless you have a laptop. Avoid USB like the plague. If it has to be external, go Firewire.
- The central processing unit, the most important part of a PC (unless it's AMD - then it's the cooler :p). Obviously, the motherboard must fit the chip - else, you'll have a nice little expensive fireworks show (if the chip even fits in the socket). If I listed what motherboards take what chips, this guide would be dozens of pages long. All I can say is, check the board you're buying, check the chip, and if they match, good for you.
Besides just fitting in the socket, you have to make sure you board can handle how fast or how slow your chip is. A given motherboard may only support up to a 500 mhz Celeron, so if a 600mhz Celeron of the same socket type is plunked in, one of two things will happen - 1) the system won't boot, or 2) the system will boot, but the 600 mhz will be underclocked to 500 mhz.
AMD is usually cheaper, the latest chip costing around $450, while Intel's latest is around $650. Hopefully you won't be spending that much on just the processor. Look up and down the speed scale, but don't dip lower than 1.4Ghz (that's what good ol' uncle TPC runs, and he's grown tired of it).
Intel offers better thermal protection, and a faster front-side bus than AMD, however. An AMD chip will literally melt within a few seconds if its cooling system fails, while newer Pentium 4s will step down in speed to keep themselves cool. The fast front-side bus comes in handy, especially for gamers.
Obviously, the CPU will make a major impact on how your system runs. A 1.4Ghz chip with a Radeon 9800 Pro is kind of like trying to run an 18 wheeler on a 4 cylinder. It's not a good idea to skimp on the CPU, so that you have cash for things like faster RAM, or a larger HDD. You'll regret it.
- Although some of the younger folk may not remember it, there was a time when PCs didn't come with mice, or a nice polished version of Windows, or even hard drives. These were the same PCs that also lacked cooling systems, simply because they didn't need them. Come rain or shine, freeze or heat wave, these systems remained stable, even under a full processor load.
What I wouldn't give to have all chips nowadays behave the same way.
A cooling system is an integral part of a PC, especially if you own an AMD. You don't necessarily have to dump a lot of cash into something to keep your system cool, but take a moment to consider where you live. How hot does it get outside? How cold? Does much air move through your house? All of this can factor into what sort of cooling you need.
Air cooling should suit any home user who doesn't plan to do any overclocking. The only problem with air is the noise. If you're like me, and leave your PC on overnight, then you'll quickly become annoyed with two case fans and a CPU fan buzzing away your sweet dreams. When shopping for a heatsink and fan, pick something that will let you sleep.
Next is the heatsink itself. What's it made of? Copper? Aluminum? I recommend copper. How big is it? Is it rated for your chip? Check all of this.
Lastly, for air cooling, is how fast the fan spins (this has a direct relationship with how much noise the thing will produce, obviously). For smaller fans, 5000 RPM is good for the home user, maybe 7000 or higher for those who endure higher temps.


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When astronomers using NASA's Spitzer Space Telescope turned their attention to a well-known cluster of galaxies called Stephan's Quintet, they were, quite simply, shocked at what they saw. There in the middle of the cluster, invisible to our eyes, lurked one of the biggest shock waves, or "sonic booms," ever seen. Astronomers hope that observing how galaxies generate such huge shock waves will lead to a better understanding of what powers the most luminous galaxies in the universe.
For some time now, astronomers have known that four galaxies in this distant cluster (and a 5th unrelated foreground galaxy -- hence the name "Quintet"), located about 300 million light-years away from Earth, are involved in a violent collision. In visible light, the galaxies are clearly distorted, indicating that they have experienced gravitational encounters in the past. But that, as it turns out, is only part of the drama.
One of the four galaxies, called NGC 7318b, for reasons not fully understood, is currently falling toward the others at high speed, generating a giant bow shock in front of it which can be seen in X-ray, infrared, and radio light. Amazingly, the surface of the shock wave is larger than our own Milky Way galaxy, and stretches across intergalactic space between the colliding galaxies.
Shock waves occur when an object moves faster than the speed of sound through any kind of medium -- from water to intergalactic gas. One of the most commonly observed forms of shock waves is the sonic boom produced by high-speed aircraft. As a supersonic jet exceeds the speed of sound (or Mach 1), it catches up with its own sound waves. The sound waves become compressed together into a cone-shaped "shock" which travels outwards towards the ground and produces the familiar "sonic boom" when a supersonic jet flies by. The sonic shock is usually invisible to us, but in one case, a Navy ensign was able to capture a spectacular photograph of a shock wave extending behind a low-flying jet over the ocean. As water vapor in the air was compressed by the shock wave, it condensed into droplets and formed a conical cloud behind the tail of the jet (see image).
A U.S. Navy fighter jet breaks the sound barrier, creating a shock wave.
Dr. Philip Appleton (Caltech) and collaborators turned Spitzer's sensitive Infrared Spectrograph toward the location of the giant shock wave, a visibly dark area between the galaxies, hoping to discover more about what was going on. Unlike an optical telescope, Spitzer has the ability to detect infrared light from invisible materials, like dust grains or molecules.
To their surprise they discovered the telltale fingerprint of extremely powerful molecular-hydrogen. "The strength of the emission and the fact that it shows the gas to be Doppler-broadened (astronomer-speak for "highly disturbed") was a huge surprise to us." said Appleton. "We expected to see the spectral signature of dust grains -- but instead we saw an almost pure laboratory-like spectrum of hydrogen molecules and almost nothing else. It was quite unlike anything we had seen before in a distant galaxy system."
Spectrographs have the ability to break light down into its component wavelengths, where the chemical signatures of the material that produced it can be seen as spectral lines. The width of these lines allows astronomers to determine the velocity of the gas, with wider lines indicating gas at a higher velocity. Appleton and his team measured the widest lines ever observed for hot hydrogen molecules, corresponding to turbulent gas motions of 870 kilometers per second (2 million mph)!
"In Stephan's Quintet," says Appleton, "the shock wave is due to the intruder galaxy (NGC 7318b) traveling at speeds greater than Mach 100 as it plows into intergalactic gas within the cluster. Hydrogen molecules are apparently forming either in or behind the shock, similar to the water droplets condensing in the jet image -- but on an enormous scale!"
In a way, the discovery of something so new and unusual was not such a big surprise to the team, as the dynamics of this cluster are far from understood. Dr. C. Kevin Xu (Caltech), one of the team members says: "Stephan's Quintet is such a unique object that every time it is looked at with a new instrument, it reveals totally unexpected things. No exception this time."
This discovery may lead to a better understanding of the most infrared-luminous galaxies in the universe, the mysterious Ultra-luminous Infrared Galaxies. "Ultra-luminous Infrared Galaxies typically have infrared luminosities 100 to 1,000 times greater than the Milky Way, and their numbers increase as you look out to higher and higher red-shifts," says Appleton. "We know that these galaxies are also involved in vast mergers and collisions. It's possible that some of the emission we see from them is created not by stars, but by vast shocks in the gas between colliding galaxies."
The observations presented by Appleton and fellow team members C.K. Xu and W. Reach at Caltech, as well as other astronomers in the US, Germany and Australia, provide a new diagnostic for studying conditions in merging and colliding galaxies in the early universe.
"Observing a relatively nearby densely populated galaxy group immersed in a thick gas cloud, gives us a local view of what might have been going on about 10 billion years ago, soon after the first galaxies formed, when the density of the intergalactic medium and the density of galaxies was much greater than today. In that respect these observations are a bit like stepping into a time machine," said Drs. Cristina Popescu and Richard Tuffs, two other team members from the Astrophysics Department of the Max-Planck Institute in Heidelberg, Germany.
But this discovery has implications even for our own galaxy, the Milky Way. Though far in the future, it is likely that in about two billion years from now, we will collide with the slightly larger Andromeda Galaxy, creating shocks of our own. In that case, our future descendents will have a ring-side seat!


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Will Smith is all too aware of the Uncle Phil comparisons.
After the 48-year-old actor shared a GoPro video of himself bungee jumping in March, screenshots went viral as fans began to compare him with his Fresh Prince of Bel-Air uncle, Phillip Banks. While appearing at a press conference for his upcoming film, Bright, at San Diego Comic-Con 2017 on Thursday, a Huffington Post reporter asked Smith about the hilarious photos.
"I don't know if you saw, but a lot of fans isolated one moment where they said you reminded them of..." the reporter began.
Uncle Phil was played by James Avery, who died at age 68 in 2013.
"Some of my greatest lessons in Acting, Living and being a respectable human being came through James Avery," Smith wrote upon his co-star's death. "Every young man needs an Uncle Phil. Rest in Peace."
Members of the Fresh Prince cast reunited in March to celebrate 20 years since the '90s sitcom's season finale. Alfonso Ribeiro, who played Smith's cousin, Carlton Banks, commemorated the special moment on Instagram at the time, and added a touching tribute to Uncle Phil.
"Always amazing to spend an afternoon with my Fresh Prince family," Ribeiro captioned the photo of the cast. "Wishing that James Avery was still with us to make this complete."
See how Smith celebrated the 20-year anniversary of Men in Black in the video below.


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Q: Should I use group by to make this query? So I have this table in my rails app:
create_table "scores", force: true do |t|
  t.integer  "points"
  t.integer  "exercise_id"
  t.integer  "user_id"
  t.integer  "attempt_number"
  t.boolean  "complete"
  t.integer  "count_hints"
  t.text     "attempt_content"
  t.integer  "seed"
  t.datetime "created_at"
  t.datetime "updated_at"
  t.integer  "time_taken"
  t.integer  "tutor_session_id"
  t.integer  "problem_id"
end

The context: Students work on problems that are uniquely identified by an EXERCISE_ID, PROBLEM_ID and SEED.
When a student works on a problem, any answer that is submitted will be stored in this scores table. The answer will be stored, how long it took them for that attempt, what attempt number they're on, whether that answer was correct, etc. Once they answer the correct answer, they can move on to the next problem.
What I would like to do, for a given user, is to retrieve the scores but grouped together by the given exercise_id, problem_id and seed.
I would like to have returned an array and each element is another array of all the attempts and whatnot around a given exercise_id, problem_id and seed.
I've been trying to use GROUP BY exercise_id, problem_id and seed, but if I don't use some sort of aggregator like count or sum, I don't really get back results that match what I want.
Is this sort of query grouping possible?
Thanks for the help!

A: One of the properties of SQL is that it is compositional. This means that the result of performing a SELECT on a relation is also a relation. In other words, querying a table will return another table.
The GROUP BY operation ensures just this, and as you pointed out, it only works with aggregating functions. Because of this, SQL itself can not give you a set of relations.
It is very possible to achieve this in Ruby, though. Have a look at the Enumerable module, and #group_by in particular.
http://ruby-doc.org/core-2.2.1/Enumerable.html

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text:
PM Narendra Modi celebrates Diwali with jawans in Harsil, Uttarakhand
Harsil: Prime Minister Narendra Modi, today celebrated Diwali with jawans of the Indian Army and ITBP, at Harsil in Uttarakhand.
Greeting the jawans on the occasion, the Prime Minister said that their devotion to duty in the remote icy heights, is enabling the strength of the nation, and securing the future and the dreams of 125 crore Indians. He said that Diwali is the festival of lights; it spreads the light of goodness and dispels fear. He said that the jawans, through their commitment and discipline, are also helping to spread the sense of security and fearlessness among the people.
The Prime Minister recalled that he has been visiting soldiers on Diwali, ever since he was the Chief Minister of Gujarat. He also spoke of his interactions with the jawans of ITBP, years ago when he was part of the Kailash Mansarovar Yatra.
The Prime Minister said India is taking great strides forward in the defence sector. He spoke of various measures being taken for welfare of ex-servicemen, including OROP (One Rank, One Pension).
The Prime Minister said that the Indian Armed Forces draw admiration and appreciation across the world, in UN peacekeeping operations.
The Prime Minister offered sweets to the jawans. He also interacted with people from nearby areas who had gathered to greet him on Diwali.
Previous articlePM Narendra Modi offers prayers at Kedarnath Temple; takes an overview of progress of reconstruction projects
Next articleVice President successfully completes 3-nation Africa Visit
Odisha to display Biju Patnaik's Dakota Aircraft at Bhubaneswar airport; seeks AAI approval
Government is committed to doubling farmers income by 2022 through various schemes: Narendra Singh Tomar
Thermal Screening of passengers arriving from China including Hong Kong expanded to Seven airports now


Gorgeous black polka dot and floral swing dress from My Vintage!
We love a quirky print and this polka dot and floral print dress is amazing!
Gorgeous vintage style dress in black with white polka dots and rose rose print from My Vintage. Halter neck with back zip fastening. Can be worn with or without the black sash tie belt. Add a petticoat for more volume for the evening or wear without during the day or night. The shape is extremely flattering as it fits at the waist and flares out. This has an elasticated panel to the back which makes it a great flattering fit for all bust sizes.
This is a brand new item from our own label vintage style range of clothing.
S (10/12) - Bust - 32-34" Waist - 29" Length - 44"
M (12/14) - Bust - 34-36" Waist - 31" Length - 44"
L (14/16) - Bust - 36-38" Waist - 33" Length - 44"
XL (16/18) - Bust - 38-40" Waist 35" Length - 45"
XXL (18/20) - Bust - 40" Waist 37" Length - 45"
I bought this for a fifties themed party in November. It is absolutely gorgeous, silky material and looks amazing with a 'floofy' petticoat. I can't wait to wear it and think I am a convert to the fifties look!


Entire 3-bedroom house, including basement, doors, ceiling, trim, walls, and outside doors.
Very happy with the job completed by this company. We had a very tight timeline, and Scott and his team (Ross and Augie) accommodated us. The quality of the job is outstanding - far exceeded my expectations. I would recommend them to anyone.
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text:
Hiraya, Nagano
Hiraya Village Hall
Location of Hiraya in Nagano Prefecture
Coordinates: 35°19′23.9″N 137°37′48.7″E / 35.323306°N 137.630194°E / 35.323306; 137.630194Coordinates: 35°19′23.9″N 137°37′48.7″E / 35.323306°N 137.630194°E / 35.323306; 137.630194
Shimoina
1057-banchi, Hiraya-mura, Shimoina-gun, Nagano-ken 395-0601
Hiraya village
Hiraya (平谷村, Hiraya-mura) is a village located in Nagano Prefecture, Japan. As of 1 September 2018[update], the village had an estimated population of 414 in 192 households,[1] and a population density of 5.4 persons per km². The total area of the village is 77.37 square kilometres (29.87 sq mi).
Hiraya is located in mountainous southwestern Nagano Prefecture, surrounded by 1500 meter mountains, and bordered by Gifu Prefecture to the west. Hiraya is at an average altitude of 900 meters, and contains Mount Ōkawairi and the source of the Yahagi River.
The village has a climate characterized by hot and humid summers, and cold winters (Köppen climate classification Cfb). The average annual temperature in Hiraya is 9.8 °C. The average annual rainfall is 2106 mm with September as the wettest month. The temperatures are highest on average in August, at around 21.8 °C, and lowest in January, at around -2.1 °C.[2]
Per Japanese census data,[3] the population of Hiraya has declined by more than two-thirds over the past 80 years.
657 −3.2%
712 +15.4%
The area of present-day Hiraya was part of ancient Shinano Province. The village of Namiai was established on April 1, 1889 by the establishment of the modern municipalities system. A portion of Namiai separated to become the village of Hiraya on April 1, 2006.
The economy of Hiraya is based on tourism to its ski and hot spring resorts.
Hiraya has one public elementary school operated by the village government and one public middle school shared with the neighbouring village of Achi. The village does not have a high school.
The village has no passenger railway service.
National Route 153
^ Hiraya Village official statistics(in Japanese)
^ Hiraya climate data
^ Hiraya population statistics
Media related to Hiraya, Nagano at Wikimedia Commons
Retrieved from "https://en.wikipedia.org/w/index.php?title=Hiraya,_Nagano&oldid=1125651283"


Quote from Chandan Kumar Hello everyone, so the stage is finally set for the most awaited alumni event of recent times --The Career Counseling. Feel free to contact me regarding your queries on journalism as a career, its pros and cons. Someone who has quit mechanical engineering in the very first semester, to follow the passion of Journalism, may be good enough to guide you if you have any sort of affinity towards opting the field as career.
So bombard me with questions, may be I can be of some help to aspiring juniors.
About me: With 2 years , 5 months experience working with PTI news agency in New Delhi. Currently I am a Senior Copy Editor.
Hlo bhaiya..i m in class 12 at present...cn u pllz tell wht i hv to do aftr 12 for doing journalism?
Jyoti what I did was the same ask your family not to engage in any other activity that's the most important. family members will also have to cooperate. Yaar 4-5 baar mana kar do yaar ki nhi karenge....2 saal ki to baat hai. Wo khud hi tumko nhii bolenge kuch..but haa ye tabhi jab tum poora time utilise kar rahi ho. .. Maine apne parents ko bol diya thha and they didn't engage me any kind of activities. So that is also important....aur agar tum din mei 10-11 hours padh leti ho then that is more than sufficient.
IPCC Bhaiya..In ca u should always try to prefer the morning classes also try that at any cost u should not bunk the classes and what u study in classes always go for revision at any cost what u have studies at morning and this phenomenon should going on regularly.
Yes Bhaiya. But now a days I unable to mange the tym for study all subjects.
You are in which standard??
I would like to ask bhaiya ia that how you used to manage to learn the chemistry reactions?
The very first thing that you must ask yourself before choosing journalism as a career is that whether or not the idea of describing events, things, personalities interest you or not. You should have an excellent command over language -- English and Hindi. Although even one language would work but then to excel, you must be proficient in both the languages.
Hello dr.ayush bhaiya...i also need some help regarding neet 2018 as i m a dropout and last year i scored 410 in neet and this year want to gain 550+ for a good medical collg. Although the tym is now very less bt pls. Elaborate some strategy for final revesion and time management in phy. Chem. And bio.
dr swapnil, dr ayush, dr ayush, Anjalika Shalini is a 11th standard bio student and wants to know how to prepare for NEET. from april, she will be in 12th.
ministry of Shipping ,Govt of India to my Home then my parents knows and full credit goes to my family for that ...and today my Younger sister she is also engineer in LnT company and working in FRANCE since last 11 months ...and I got job at age of 18.5 yrs and today itself travelled almoast whole world...self believe and Believe on God is most important....again I m telling u anybody can crack exam and I did in 1st attempt then why not u or anyone else ...!!
Go through ML KHANNA. It is one of the best book of mathematics it contains solution as well. Go through it twice it's okay if you have to see the solutions.it contains several question of same type and will help you alot.
Lots of people want to know about how to prepare for NEET.


Worked in: Has traveled globally for business for several years. Recalls her favourite 24-hour period involved walking from the Eiffel Tower to Notre Dame and then from Tiananman Square to the Forbidden City.
Kristi Argyilan practices what she preaches: that media and messaging should mirror the values of the brand.
She'd also characterize herself a leader in "new world order" media channel strategy and marketing communications that comes from a "center brained" approach to every challenge that underscores a balance between intuition, insight and analytics.
The technology industry is constantly changing, and media concepts need to evolve at the same speed. Kristi has proven her ability to go beyond just keeping up with innovation; she has anticipated technology trends in her work with brands like HP, eBay, E*Trade, Vonage, and Progressive Insurance. As Lead of Transformation, Kristi helped operationalize Media 3.0, and now focuses on product transformation and the deployment of Media 3.0 globally.
In her previous role as a Global Managing Partner, Kristi managed global media investments and was responsible for setting vision and executing a new media model. In addition to her work as account lead for Microsoft, Kristi runs the UM San Francisco branch. She maintains close ties to Silicon Valley.
Dictionary definitions aside, how would you characterize innovation in the work you do? In my work, what really matters is delivering the most innovative combination of talent, tools, data and technology to the organization so more of our employees can deliver innovation in everything they do. In our organizational design, low value work is automated; investments in talent center on bringing a new point of view to our clients' marketing programs; and data and tools are designed to prove that the right innovations drive our clients business forward.
Why do people see you as an innovator? I am an organizational innovator. I have the vision and the operational acumen to execute so my conceptual plans can be seen in tangible results and execution. I am brave. I will tackle anything if I believe it's the right thing to do; knowing that my vision cannot take a straight road as its being executed. I am also naturally curious about the "chemical reaction" that occurs by unexpected pairings of unique minds, skills and personalities.
What is the biggest challenge you face in applying innovative thinking to international projects? Inconsistencies of talent and data sources throughout the industry.
Any other interesting aspects to your international background? My most life changing event was building a school in Oloosiyoi Kenya in May 2010. It was very important to me to not only support the organization that does this as its charter, but to also meet the families in the village (some of the most beautiful people I will ever know) while physically helping to move education forward for a few children.


Mice treated with a brain enzyme inhibitor performed better in memory tests than untreated mice. Spatial memory is key to being able to function independently, whether navigating your way around a shopping complex or finding your way around your kitchen.
The inhibitor reduced the activity of a brain enzyme that damages the hippocampus and reduces spatial memory. Mice that had been treated performed better in mazes than untreated mice.
Loss of spatial memory is associated with a number of degenerative conditions of old age, such as Alzeimer's disease, so any treatment that can diminish this loss would be extremely useful to the third of us who will suffer memory loss with ageing.
As no side-effects from the treatment have been detected so far, the treatment is expected go into human trials in the near future.


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text:
The WTO Opts for Greed and Profits Over Providing Vaccinations for All People Worldwide
in World — by Prabir Purkayastha — 23/07/2022
The health of all people is being sacrificed to Big Pharma profits and rich countries' saber-rattling sanctions. Meanwhile, other countries are capable of meeting the world's vaccine needs.
The UNAIDS Executive Director Winnie Byanyima had appealed before the 12th WTO Ministerial Conference in Geneva that the world would face a grim future if patent waivers did not take place. At a press conference, Byanyima had said, "In a pandemic, sharing technology is life or death, and we are choosing death." During the 12th Ministerial of the World Trade Organization (WTO), which took place from June 12 to 17, the rich countries did precisely that. They blocked almost all possibilities of providing cheap vaccines, antiviral drugs and diagnostics to the world. After two years of the WTO "postponing"—or blocking—the India-South Africa proposal for a waiver on patents for COVID-19 vaccines and medicines, the club of the rich countries—the European Union, the United States and the UK—ensured that no worthwhile patent waiver measure was passed. The profits of Big Pharma once again trumped the lives and health of the people. This is also what happened during the AIDS epidemic.
The so-called "concessions" accepted at the 12th Ministerial Conference (MC12) do simplify some of the cumbersome procedures that were agreed to under the Doha Declaration for issuing compulsory licenses for medicines. But it makes it much more difficult for countries like India and China, which have considerable manufacturing capacity, to supply vaccines under such compulsory licenses. So yes, countries wanting vaccines can issue compulsory licenses more easily—but to whom, if not the countries with manufacturing capacity?
In vaccine manufacture, it is not the formula of the vaccine that matters. Unlike many medicines, which are small molecule drugs and therefore easy to patent, vaccines are large molecules and belong to the group of medicines that are called biologics. The key to manufacturing biologics is not the formula of the compound but rather manufacturing it at an industrial scale and ensuring the production process of replicating the complex large molecules accurately. This know-how is guarded not under patents but under trade secrets. It is possible to duplicate these trade secrets or secure them by giving somebody who knows the process the job. But this opens companies that try to do this to costly legal action, including by the WTO. And there is also the threat of unilateral sanctions by the United States, the EU and the UK.
The upshot is that Pfizer and other Big Pharma companies will continue to make huge profits at the expense of people's lives, even if this leads to new SARS-CoV-2 variants emerging and causes the continuation of the pandemic. Less than 20 percent of people in Africa, which has a population of about 700 million, have been fully vaccinated, while millions of vaccine doses are going unused and are going to waste in the United States. We have the vaccine production capacity to immunize the entire global population, thus saving countless lives and reducing the possibility of new, dangerous variants emerging. But doing so is not in the interest of Big Pharma, for whom profits matter far more than human lives.
Just to put it in perspective, Pfizer's profits roughly doubled in 2021 from 2020, with the Pfizer-BioNTech vaccine contributing to a significant part of those profits. If Pfizer were a country, its earnings of $81 billion last year would have placed it ahead of the GDP of countries such as Ethiopia, Ghana and Kenya, according to an analysis of World Bank data by the organization Global Justice Now. Apart from vaccines, the monopoly over diagnostics and antiviral drugs also pushes up the costs for the people constantly battling the virus, while generating windfall profits for Big Pharma.
The only waiver in the MC12 was on compulsory licenses for vaccines. It did not address patents on diagnostics and antiviral drugs. It also did not address the other issue that had been raised that the WTO includes in its waiver other intellectual property rights such as trade secrets, which are essential to the mass production of vaccines.
The MC12 kicked the ball six months down the line on making a decision about doing away with patents for diagnostics and antiviral drugs, with very little chance that the rich countries would have a sudden change of heart on these issues, considering their continued stance on these matters over the course of the pandemic that has already killed millions.
Why is immunizing the global population important? Simply put, the more people that SARS-CoV-2 (the virus that causes COVID-19) infects, the more the chance of new variants emerging. There is a misguided belief among some people that the more the virus mutates, the more benign it is likely to become. This used to be a common opinion among a section of the medical community. However, today evolutionary biologists hold that there is no evidence that viruses mutate to become more benign. And even if it is held to be true in the long run, as John Maynard Keynes, the economist, put it, "In the long run, we are all dead."
The longer we live with a pandemic that continues to infect around half a million to a million people every day, the more we are dicing with the possibility of a new variant emerging that can be as transmissible as omicron and can also lead to larger case fatalities than we have seen before. The transmissibility of the virus is maximum when the infected patient has only mild symptoms, is physically and socially mobile, and can therefore infect others. This is the window in which the virus spreads. Whether the patient subsequently recovers or dies has little impact on the replication of the disease in other people the patient might have infected. It may have an impact on our social behavior, but that has little to do with the virus becoming more benign with time.
Over time, people do tend to generate more immunity to the virus, but that is what then drives the future evolutionary path of the virus. If delta showed higher transmissibility, then omicron has a much higher immune escape. This means that omicron can bypass our immunity derived from earlier infections or vaccines. Of course, if the evolution of the virus leads to the patient being so sick right from the beginning that the person cannot move around at all, that will halt or lower the transmission of the virus. But that is not how the SARS-CoV-2 virus behaves.
How is SARS-CoV-2 likely to evolve over the next few years? As immunologists tell us, the evolutionary trajectory of the virus depends on the complex interplay of a number of factors that shape the response of our immune system to the evolution of the virus.
Waiting for the virus to turn more benign or a mythical herd immunity cannot be an answer to the current pandemic. The vaccines are crucial to any public health response to the pandemic as countries across the world fight to cut down the number of new infections and, therefore, the roots of new transmissions. And yes, for the foreseeable future, we will have to live with repeating our vaccine booster doses as we fine-tune the vaccines to newer variants.
While the patents on antiviral drugs as a cure for COVID-19 are important, and they will certainly help to cut down the deaths and complications of long COVID, again, patents come in the way of their use. The antiviral drugs are effective only within a small window of the first few days of the disease, which means that they have to be made available cheaply for the people so that they can buy them from a pharmacy. The high cost and the control over the patents of these drugs do not provide a large enough market. A small market and high prices lead to a Catch-22 situation: the prices are high because the market is small; the market is small since the prices are high.
Again, open licensing of the antiviral drugs might make it possible to create a large market for them. But this is what the WTO does not allow. The route of compulsory licensing under the WTO is cumbersome, and its relaxation in the MC12 means that countries like India, which were crucial in fighting the AIDS epidemic, are supposed to opt out as suppliers. They then cannot become antiviral suppliers for COVID-19 as they had been for AIDS antiviral drugs.
Why don't countries that have the capacity to manufacture advanced vaccines—India, China, Russia and South Africa—come together to offer technology and supplies to the rest of the world? Why don't countries collaborate with Cuba, a biologic powerhouse, to produce vaccines locally? Cuba has developed five such vaccines, two of which are already under large-scale production.
The answer lies in the "rules-based international order" propagated by the club of the rich. The rules include sanctions on many countries, including Russia, Cuba and China. For those not yet under sanctions, there is the threat of future sanctions by the United States, the EU and the UK—the gang of three that teamed up in the WTO to defeat the India-South Africa patent waiver initiative. The United States also has its domestic law, the U.S. Trade Act, Section 301, for "protecting" its intellectual property under which it threatens countries with U.S. sanctions. India and China figure prominently every year in the list of countries whose laws and actions do not conform to U.S. domestic laws. If the United States and its allies do not win in the WTO, they then use their "rules-based order" where they get to make the rules.
Welcome to our brave new world, where, to paraphrase Winnie Byanyima, death triumphs over life.
Prabir Purkayastha is the founding editor of Newsclick.in, a digital media platform. He is an activist for science and the free software movement.
This article was produced in partnership by Newsclick and Globetrotter.
Author: Prabir Purkayastha


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Do you have a crush on someone on tumblr? If you do, you can share your story here. You also have the option to be anonymous. So don't be scared.
2009-11-15· How do I post my tumblr crushes as a blog post because I tried to save the image and it only saved the heart so yeah.
I am a light blue Pegasus with a blue mane and a broken wing so I can't fly very well and my cutie mark is two crossed wings with thunder bolts in place of the bottom feathers.
[edit – feb 2013] Tumblr recently had an update and as yet Missing-e hasnt been update dto accommodate the changes so the instructions below on how to use Missing-e to post your Tumblr crushes is no longer correct.
Tumblr Crushes! - I will Fail. Upwards.
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text:
Molly Schuyer celebrates after winning the Hwy 55 Burger, Shakes & Fries World Hamburger Eating Championship.
Molly Schuyler Sets World Record at Hwy 55 Hamburger Eating Championship
Very few people can hold their breath for 1 minute and 25 seconds.
And only one, almost inexplicably a 100-pound (soaking wet) petite mother of four, can eat seven stacked hamburgers—55 ounces (3 and a half pounds) of ground beef in that same time, a world-record in the 55 Challenge.
Yet, it happened this past weekend, as Molly Schuyler, the No. 1 ranked independent competitive eater in the world, topped her own world record for the second consecutive year in the Hwy 55 Burger, Shakes & Fries World Hamburger Eating Championship, the only officially sanctioned hamburger-eating event in 2018 by All Pro Eating.
At the event, Hwy 55, the Mount Olive, NC- based highly decorated retro-themed burger joint, put its world-famous 55 Challenge on center stage. In the 55 Challenge, competitive eaters see who can devour seven stacked Hwy 55 burgers in the fastest time.
"I haven't slept for four days and haven't eaten in three," said Schuyler pre-competition and who flew 2300 miles for the $2500 prize. "But Hwy 55 is like family to me. And when I get in a zone, I stay in it until I do what I came to do."
"We have just witnessed the most amazing eating exhibition in history," says Hwy 55 president Kenney Moore, who founded the brand 27 years ago and flipped every burger in the brand's first two years. "Our 55 Challenge is important to the brand despite its 90 percent fail rate. It is not meant for the weary kind or faint of heart or belly. Molly is the brand's biggest fan and the most spectacular eater phenom in the world. She simply continues to amaze."
At any of Hwy 55's 137 locations, guests can take the 55 Challenge themselves. If they can consume seven patties and at least four trimmings on a bun with fries and a 24-ounce drink in 30 minutes, its free and Hwy 55 will put the guest's name on its web site for bragging rights. If the guest is unable to finish the meal in 30 minutes, it costs $29.99.
"The World Hamburger Eating Championship is officially sanctioned and has become the most influential eating championships for our sport," says Todd Greenwald, chairman of All Pro Eating Promotions, who also sanctions wings eating and other nationally-recognized and sanctioned competitions. "When Molly's jaw works, our jaws drop. She is a special woman with a once in a lifetime talent."
The World Hamburger Eating Championship is Hwy 55's foray into full-on competitive eating although the brand is well-known by the burger-loving public as well as the restaurant and franchising industries.
Once a well-kept secret in tiny but vibrant Mount Olive, North Carolina, Hwy 55 now operates 137 restaurants and has sold the rights to more than 1,000 franchise locations around the world. Hwy 55 has also signed franchise area agreements for Texas, West Virginia, Louisiana, Kentucky and southern Indiana and Virginia in the past year. The brand plans to open approximately 25 more locations in 2018.


Despite the fact that writing a definition essay can be an extremely difficult assignment for you, it doesn't mean that you cannot do it. Even if you have a too complicated task, such as writing definition essay on American dream, you can easily complete this task. To do it, you have to know several crucial aspects of this type of papers, which our professionals have already collected in this article for you. We try to give you the most useful tips on writing American dream definition essay without any problems.
The definition essay is a paper, which explains its readers the meaning of specific and rather complex phenomena. The best examples of such phenomena are love, freedom, friendship, independence, religion, happiness, American dream and a huge list of other words and phrases that cannot be explained in two words and require argumentative explanations. To make the long story short, this paper should make a difficult and ambiguous notion much easier for understanding.
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The first thing you have to do to start writing a definition essay is to select a proper word or phrase. You should remember that it should be a complex word (for example, love, peace, freedom, kindness, etc.) and not a concrete object, for instance, pen, apple, paint, cup, etc. In our case, we have a rather complicated notion "American dream," so we don't have to choose some other. Before starting to write the essay, try to understand what you already know about this notion, what do you need to find out, and where you can find the answers to all your questions. This process will help you to write a paper much faster.
Despite the fact, that there are many American dream essays on the Internet, it doesn't mean that all of them are correct. Actually, your essay introduction should include several sentences (1-3), which will be the most important in the whole text, the so-called, the text hook. Here you must write the definition per se.
For instance: "American dream is a belief that every person can become successful and happy in all live spheres, no matter where she or he was born, and no matter what social status has. It is not a chance, but hard work with all strengthens and weakness to have everything that he or she wants in life." Besides, it will be even more useful and correct, if you firstly, give an encyclopedic explanation, and only after that present your thoughts and feelings about this or that notion. Moreover, you can add some interesting fact about the origin of the word or phrases, using some historical or lexicological literature resources.
1st - is an introduction, which is considered one of the most significant parts. Here you should highlight the main aspects of the definition per se, saying what the American dream is.
2nd - The main body of your American dream definition essay is the second part. This part should include 2 or 3 paragraphs. The first paragraph of the main body should express the first part of your definition and the second part - the second component of your definition.
The last part of your text is the conclusion. The final paragraph of your text should be very informative, because you should collect the main facts and results from the whole story, making ground and a strong conclusion. Remember, that you cannot repeat your thoughts from the previous paragraphs in the same words; you must paraphrase it.
Reread your American dream definition essay several times to avoid little grammatical and lexical mistakes. It will be very useful if you ask your friend to read your story one more time; it can give you a new highlight on some crucial issue that you could miss.
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CitiesDecember 2020Public Sector
Niagara Falls, Ontario – Two marvelous cities in one
Two marvelous cities in one
Business View Magazine interviews Jim Diodati, Mayor of Niagara Falls, Ontario, for our focus on Economic Development in Canadian Cities.
Imagine living in a small, friendly city of around 90,000, enjoying going about your daily business as part of a close-knit community… one where 14 million people come to visit and say "hello" every year! Welcome to Niagara Falls, Ontario – home to a pretty big water feature and an even bigger heart.
Located in North America's most affluent consumer market, Niagara Falls is a globally-recognized city with a prosperous business community anchored by tourism, manufacturing, commercial retail, and knowledge-based sectors. Extensive road, rail, water, air, and telecommunications networks make the city easily accessible as a destination for both work and pleasure.
With the U.S./Canada border closed now for several months due to the COVID-19 pandemic, Niagara Falls, Ontario has seen its visitor traffic and revenue do a deep dive. But the city has pivoted to embrace its 'non-Falls attributes' and is experiencing strong economic and population growth in the process. Business View recently spoke with long-term Niagara Falls Mayor Jim Diodati, who shared his candid insights into the challenges and successes taking place in the city he loves. The following are edited highlights of our conversation.
Mayor Jim Diodati with local manufacturing
BVM: How is the city faring as a destination during the pandemic?
Mayor Diodati: "Niagara Falls is a unique place. We say we're the biggest small city in Canada; less than 100,000 people but when you factor in the 14 million visitors, it gives us a weird mix and unusual things happen. We knew we were at risk because of the massive amount of people that come to Niagara Falls. There were predictions of "Florida north" but none of it happened. Even the critics were saying we were just lucky – but seriously, lucky for three months? I don't think so, I'm not that lucky.
"Collectively as a destination, we worked hard, did a good job, and kept our numbers as low as any other city that doesn't get tourists. There was a lot of proactive planning by good, dedicated people. Of course, we were worried… in Niagara Falls, we have 40,000 people counting on tourism to put food on the table. Failure was not an option. And closing down the destination was not an option either. We had to open up safely. And we're proud of the outcome."
BVM: With the Canada/U.S. border closed has regional visitor traffic increased?
Mayor Diodati: "Definitely. Labour Day weekend was as busy this year as any other year. Typically, 25 percent of our guests come from the U.S. So, we were happy with the numbers because a lot of Canadians that would normally cross the border stayed here. The other thing that stings about the border piece is although the U.S. represents 25 percent of our guests, they represent 50 percent of the revenue. So it's a significant piece of the cash flow that didn't happen. We definitely miss the Americans but we cushioned the blow with Canadians visiting their own destination.
"Obviously, it wasn't a great summer; it will definitely be marked with an asterisk. A lot of people were hurt and are still hurting and some businesses never made it. But it could have been much worse, given the fact that we got hit from both sides. The fact that tourism was shuttered for a great deal of the summer, and people are discouraged from visiting – certainly in big numbers, which we are known for – that definitely didn't play to our strengths. But overall it worked out well."
BVM: Thinking beyond tourism, what other projects are on the go?
Mayor Diodati: "The Niagara South Hospital project is moving forward nicely. It is still in the planning stages, and we're anticipating ground breaking in 2021/22 (subject to the Province of Ontario). Then it will be a few years for the build. Of course, COVID has thrown schedules sideways but we have not slowed down on the planning aspect and the zoning and all the infrastructure the city has to do. We're working closely with the Niagara Health System and the Ministry of Health to make this happen. With a price tag upwards of $1 billion, it will be a state-of-the-art, machine learning hospital that will have the benefit of being designed after SARS and COVID, so they will have learned a lot about ventilation systems, etc. And it's long overdue, our current hospital is antiquated. The new complex will serve Niagara South and be built on 50 acres – 30 of which were donated by a local family and 20 acres that were purchased by the city. The entire acreage has been assembled and transferred to the Niagara Health System, so we're really excited to move that ball forward.
Scotiabank Convention Centre
"Also, we've committed and are in the midst of commencing $4 million of investment in upgrading our GO Train station, which will include the station building, the platforms, the parking, streetscape improvements, some underground and roadway upgrades. We're the terminus for the GO Train – it starts and ends here in Niagara Falls – and the AMTRAK comes into our station from Niagara Falls, New York. And there is discussion of high-speed rail connecting Toronto and New York – the beauty is it goes right through our city. Knowing that the GO Train expansion will happen, we've outpaced all the predictions and we meet regularly with Phil Verster, CEO of Metrolinx. He is very supportive of expanding to Niagara Falls. That's going to be a very important aspect of our infrastructure and it will become more important with environmental concerns and congestion on the highways."
BVM: Why are people migrating to Niagara Falls from larger centers?
Mayor Diodati: "Our population has been exploding. People are seeing Niagara Falls as a great place to live because their dollar goes much further here than in the GTA (Greater Toronto Area). Toronto is the fastest growing urban center in North America and as their growth continues, so will ours. Our quality of life is outstanding, with 130 wineries, 35 golf courses, great restaurants and attractions, cross-border shopping – and now we're going to be connected with the GO Train, and you can also take a 12 minute flight with GT Air and be in downtown Toronto. With COVID, and the advent of working remotely, a lot of people have decided to move to Niagara and work from home here.
"We've got a great school system, a very low crime rate, and Niagara Falls was just recently ranked one of the top 10 cities in the world to live. People realize it's a good place to raise a family or retire, and as a result there's been a major boom in house construction and new residents moving to the area. We've become much more multi-cultural as well, with a lot of different demographics coming into town."
BVM: Is your business sector growing as well?
Mayor Diodati: "We've been selling at a record pace and struggling to keep up with demand in our industrial parks. In fact, we've had to put sunset clauses in all land purchases down there that if they don't build and develop within a certain period of time, we buy the land back at the same price. We don't want to tie up property for speculators and land banking, we only want people who are serious about building their business to create employment and economic development. And that's exactly what's been happening. We've been rapidly running out of space and having to expand our industrial parks. And there is no shortage of jobs. It's a sign of a healthy economy. And we're really happy with the direction it's gone.
"With our hospital there are some really interesting high-tech companies in the nanotechnology and pharmaceutical sectors that are looking to move here. We've got light manufacturing, as well. Because we sit on the border, that's a big advantage. Anywhere in the world, when you say Niagara Falls it's instantly recognized as one of the most well-known cities on the planet. So it's a benefit to have your corporate brand associated with the City of Niagara Falls. A lot of small to medium-sized companies are locating here and we're happy with that because smaller companies are more resilient to changes in the economy and more committed to the destination."
BVM: Is entrepreneurialism alive and well?
BVM: "Yes. We've got a great partnership with the Niagara Falls Ryerson Incubation Hub in our downtown. It's right across the street from the GO Train station and one block from the Niagara River, which is about a three-minute drive to the tourist core. So, you start to realize how important its location is and it will be very significant going forward. This is going to be a great way to incubate ideas and create an entrepreneurial village in our downtown area.
"We've had quite a few success stories already and we're just getting going. Ryerson University is the number one ranked incubator in the world and our direct partnership with them links us with all their other locations around the globe. That, coupled with new and emerging technologies companies in our business park, is creating a whole new list of opportunities for businesses that are willing to pivot with what's happening in the world today."
BVM: How would you sum up the best attributes of life in Niagara Falls, Ontario?
Mayor Diodati: "If you haven't been to Niagara Falls in the last 10 years, you haven't been to Niagara Falls. Being one of the great tourist attractions of the world, people don't realize the excellent quality of life in a city that's so well known. We still have that small town feel, where people will get out of their car to push you if you're stuck in the snow, and they know you at the local shops. Yet, we have all the big city amenities because of the millions of tourists that come here. Niagara Falls offers a buffet of opportunity with two distinct faces – the tourism powerhouse and the cozy community that people love to call home."
WHAT: A city of 90,000
WHERE: On the Canadian side of the Niagara River
WEBSITE: www.niagarafalls.ca
Ryerson University – Ryerson.ca
Niagara Falls Ryerson Innovation Hub
The Niagara Falls Ryerson Innovation Hub (NFRIH) is a business incubator focused on growing digital products and services for local entrepreneurs. Founded by the City of Niagara Falls, Ryerson University, and Spark Niagara, NFRIH has created an educational ecosystem, which fosters entrepreneurial growth.
Located in the heart o f downtown Niagara Falls, NFRIH not only focuses on developing businesses, but also takes pride in setting the stage for individual growth.
Canada's leading tech incubator-accelerator, the DMZ at Ryerson University, serves as the model and key resource for NFRIH's programming and services, focusing on community, coaching, customers, and capital. Entrepreneurs in the Niagara Region can now access these proven resources without leaving the p lace they call home.
The four-month NFRIH program provides startups with access to hands-on advice from the DMZ's experienced industry-leading experts and entrepreneurs-in-residence (EiRs) who have done it all before, and the resources needed to take businesses t o the next level. These Ryerson resources include:
Connections to international markets
Ability to leverage the Startup Visa Program
Access to exclusive workshops and events
Connections to Ryerson's research a nd development ecosystem
Custom program curation based on business needs One-on-one consulting with leading experts
The ultimate focus of the NFRIH is to work with startups to create a structured, scalable and repeatable process for growth and revenue generation.
Graduates of the NFRIH program include: Get Ready Global and Marion Surgical
The NFRIH is currently recruiting its fourth cohort for a start date of Jan. 18, 2021. If you are interested in applying or learning more please visit: https://www.niagarafallsryersonhub.ca/
E.S. Fox Limited – www.esfox.com
Established in 1934 as a small plumbing and heating company, E.S. Fox Limited (ESFL) today is recognized as a pre-eminent Canadian multi-trade Industrial, Commercial, Institutional and Power Generation constructor and fabricator. We work in the industries of oil and gas, petrochemical, mining, pulp and paper, steel, automotive, pharmaceutical, casinos, hotels, hospitals, schools, and themed entertainment.
ESFL is headquartered in Niagara Falls, Ontario, and maintains full-service regional offices in Hamilton, Toronto, Port Robinson, Oshawa, Kincardine, Kingston, Sudbury, and Thunder Bay.
We supply millions of direct-hire person-hours every year, self-performing in the areas of Structural, Mechanical, Electrical, Sheet Metal, HVAC, Refrigeration, Millwright and Rigging, and Boilermaking. ESFL is recognized as an industry leader for Industrial Fabrication and Construction by integrating Safety and Quality Assurance practices into everything we do. We honour the four cornerstones of service: Safety, Quality, Schedule, and Cost, in that order. We believe that when you manage the Safety and Quality of your work, you are better able to control your schedule and manage your costs. This successful approach is instilled into all our operations.
With a strong commitment to health, safety, and protecting the environment, ESFL has earned a reputation as a people-first, environmentally conscious, socially responsible constructor.
Mancuso Chemicals Limited – www.mancusochemicals.com
Incorporated in 1986, Mancuso Chemicals Limited is a trusted provider of products and expert technical innovation to foundries, steel & tin mills, and paint manufacturers on four continents and 18 countries around the world. Products including Foundry Resins, Chemicals and Consumables, Tin and Steel Mill Chemicals, Polyester and Alkyd Resins for the Coatings Industries, and Automotive Fluids are supplied from Mancuso headquarters in Niagara Falls, Ontario, where InterAtlas Autofluids also operates as a supplier of DEF, Engine Coolant, and Windshield Washer Fluid.
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Jim DiodatiNiagara FallsNiagara Riverontario
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UK: Fiat units change names
Fiat Auto (UK) on Friday changed its name to Fiat Group Automobiles UK.
"This change is consistent with other affiliates and with the new corporate culture at the Fiat Group, and involves a new company logo which can be seen on the company's latest product, the new Fiat Bravo, which goes on sale here tomorrow (30 June)," the automaker said in a statement.
It added the new configuration would not alter relationships with employees, dealers, and suppliers in any way.
"On the contrary, improved brand name recognition will promote better relations with the sales network, customers, and partners," Fiat claimed.
Simultaneously, Fiat Light Commercial Vehicles in the UK is changing name and logo to Fiat Professional, also with the new Fiat logo underlined with a separate 'Professional' badge. This, Fiat said, shows both the brand's identity as a part of Fiat Group Automobiles, and its obvious international vocation.
"The word Professional highlights the brand's aspiration to give the image independent status, while at the same time accentuating its ability to respond to the needs of professional customers. The most obvious proof of this is the fact that it has represented a day-to-day ally in the working world for over a century, with a role in the economic and social development of many countries," the automaker said.
Fiat Professional in the UK comprises 162 dealers, more than 70 of which are specialised, working to strict standards regarding the display of new and used vehicles, with workshops specialised in maintenance and repairs, and qualified sales personnel with specific training.
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Fiat Chrysler Automobiles UK Ltd
Fiat Auto S.P.A.


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Florida Senate Candidate: Scrubbing Of Wikipedia Page Was A "Careless Staff Mistake"
Rep. David Jolly's Senate campaign also accused a Wikipedia user of adding "propaganda" to the page on behalf of a rival campaign. That user told BuzzFeed News on Wednesday that such accusations were absurd.
By Andrew Kaczynski
Andrew Kaczynski BuzzFeed News Reporter
Posted on April 6, 2016, at 2:30 p.m. ET
BRIAN BLANCO / Reuters
Republican Rep. David Jolly, who is running for Senate in Florida, said Wednesday it was a mistake for his campaign to have edited his Wikipedia page to remove unflattering information.
"It was a careless staff mistake that I first learned about from the Times," Jolly told the Tampa Bay Times. "I stand by my full record, relationships, and life experience, and believe every day that voters and the community are best served by having as much information as possible, regardless of whether it comes from critics or supporters."
A spokesperson for Jolly, Sarah Bascom, confirmed to BuzzFeed News on Tuesday that the campaign removed references to Jolly's past career as a lobbyist, his association with the Church of Scientology, his support for same sex marriage, and political contributions he made to Democratic candidates.
Bascom had accused a unspecified rival campaign of adding what she described as "campaign propaganda" in to the Wikipedia page, singling out a longtime Wikipedia editor named "Champaign Supernova" as working for the rival campaign.
"Champaign Supernova" told BuzzFeed News that the charge was absurd, and noted as BuzzFeed News did, that much of the information deleted by the campaign was cited, and some of it had been included in his Wikipedia page for more than a year.
"Oy vey," user "Champaign Supernova told BuzzFeed News in a comment on the user's Talk Page. "It's an absurd allegation. I made my first edit to the David Jolly page on February 29, 2016. I made some minor copy-edits, added sources for information already in the article, and added a section on his 2016 re-election bid."
"I didn't remove any information or add any 'propaganda' (whatever that means). The Scientology stuff and the other information his campaign attempted to scrub has been in the article for months and in some cases for years," the user continued. "None of it was added by me, or by the other user, CFredkin, who the campaign has accused. It looks to me like a political campaign got caught red-handed trying to scrub a page, and they are now engaging in some sort of conspiracy theory to try to take attention off of their blunder. I'm not interested in engaging with it, and this is the last I'll say on the matter."
Bascom's Wikipedia account has received three warnings to no longer edit Jolly's page.
Florida Senate Campaign Admits To Scrubbing Candidate's Wikipedia Page
Andrew Kaczynski is a political reporter for BuzzFeed News and is based in New York.
Contact Andrew Kaczynski at andrew.kaczynski@buzzfeed.com.


In these videos, real AP teachers who've implemented AP with WE Service in their classrooms share their experiences, tips for success, and examples of their students' projects.
Laura explains how she fit the module into her curriculum and how the module helped students with the areas of focus tested on the AP Exam.
Chinma describes the process she used to help students choose an issue to address and develop a project.
Aaron gives specifics on how he incorporates the WE Service content in his classroom.
Celeste describes how she weaves the WE Service module themes throughout her curricular units.
Penélope explains how she integrated the WE Service content into her curriculum and how doing the projects helped her students improve their skills.
Pamela describes a project that her students completed and gives details on how she adds AP with WE Service content to her curriculum.
Laura offers best practices and tips on how to implement the program successfully.
Chinma gives her recommendations for overcoming what she found to be the main implementation challenge.
Aaron shares his tips for implementing the program: Create a timeline and set milestones.
Celeste describes some of her specific challenges in integrating the WE Service content and how she addressed them.
Penélope explains the challenges she faced when implementing the program—lack of time for both teacher and students—and gives tips for success.
Pamela shares her biggest implementation challenge and her two top recommendations for success.
Laura describes a student project—organizing a venue for distributing donated goods—and the skills it required of her students.
Chinma shares three of her students' projects, including creating a quiz app for teaching mathematics to elementary school children.
Aaron describes several student projects, including fundraising and awareness-raising initiatives as well as hands-on work helping restore a damaged wetland area.
Celeste shares two projects from her classroom, a Walk for Water fundraiser and a humanitarian-mapping initiative.
Penélope talks about some of her students' projects, including a food drive, a coat drive, and a fundraising partnership with a nonprofit organization in Guatemala.
Pamela describes several individual and group projects, including an initiative to encourage the use of reusable water bottles to reduce waste.


Wellington running club, Scottish Athletics is one of New Zealand's largest running and walking clubs. Wellington Scottish Harriers is open to all levels of runners & walkers from beginners to elite level.
The LIFESTYLE SPORTS Scottish Night of Miles is an annual event organised by Wellington Scottish Running Club. It is a unique event full of Christmas fun and features races over the rarely run distance of one mile.
The afternoon consists of a mix of children's, senior and junior races, fun social events and serious events. Highlights are the mile races. There are several different mile races including elite men's and women's races and an all-comers mile that anyone can participate in (including Father Christmas).
The mile is the ideal distance for people who think they might be interested in running to train towards because it is a mixture of speed and endurance. Anyone can do it but it is still a challenge and an accomplishment. And it is such a historically important distance in NZ's athletic history.
We have got permission again to host our event at the Basin Reserve, which should be really exciting for the crowds.
Each year we collect donations from athletes and spectators then hand them on to a local Wellington charity. This year's charity is Bellyful NZ. Bellyful provides meals for families with newborn babies and families with young children who are struggling with illness.


Grimcoin (GRIM) is a cryptocurrency. Users are able to generate GRIM through the process of mining. Grimcoin has a current supply of 99,937,598 GRIM with 94,300,651 GRIM in circulation. The last known price of Grimcoin is 0.000210 USD and is down 3.41% over the last 24 hours. It is currently trading on 2 active market(s) with 21 USD traded over the last 24 hours. More information can be found at http://reaper.rocks/.


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Home › News › Catwalks
Benjamin Fitzgerald
Mercedes-Benz Fashion Week Australia reveals line-up ahead of Resort shows
Mercedes-Benz Fashion Week Australia will kick off its 2019 season in mid-May, with five days of fashion shows, featuring the latest in resort collections from over 90 Australian designers, according to organisers.
The Dion Lee show at the Sydney Opera House last year - MBFWA
Iconic Australian design duo Camilla and Marc -- who first took part in Mercedes-Benz Fashion Week Australia in 2003 -- will open proceedings on Sunday, May 13, as part of the Mercedes-Benz Presents show, with their participation in the prestigious slot announced in February this year.
Now, show organisers IMG have confirmed the official MBFW show schedule, taking place in varies 'galeries' at Sydney's Carriageworks.
The most recent additions to the Australian show list include Karen Walker, Alice Mccall, Karla Spetic and Mariam Seddiq, joining runway stalwarts Akira, and Camilla, and emerging-label-turned-mainstay Macgraw.
Ones to watch this season are retro surfwear brand Double Rainbouu, who have curated a cult-like following in Sydney's eastern suburbs, the colourful Romance Was Born, and Ten Pieces, known for its monochrome, sportsluxe style and collections of simply ten items.
Missing from the Resort 2019 schedule, however, is Australian designer darling Dion Lee, who returned from New York last season to open the event. As are designer duo Sass & Bide, who returned down-under in 2017 after several seasons in New York, to present a newer, fresher design point to global buyers.
Those retailers this year will include Al Tayer, Asos, Browns, Club 21, Farfetch, Harvey Nichols, Isetan, Lambert & Associates (on behalf of Neiman Marcus Group), Lane Crawford, Opening Ceremony, Matchesfashion, Net-A-Porter, Saks Fifth Avenue, Selfridges, ShopBop and The Outnet, confirmed IMG.
MBFW Resort 2019 marks the third edition of the recently revamped Australian fashion week. Resort collections are now shown instead of the typical spring/summer or autumn/winter ranges seen in London, Paris or New York, with event organisers IMG saying that the seasonal shift puts the Australian edition in line with the international retail calendar.
"May marks the beginning of the global sales window for these lucrative retail collections," said Emily Weight, Head of Fashion, IMG Fashion Events & Properties, Asia Pacific, at the time of the change in 2016.
"The new timing and resort offering reflects our work with the industry to maintain global relevance for the region's leading fashion event."
According to IMG, Australia as a Resort destination saw an unprecedented 51% increase in buyer attendance last year.
MBFWA '19 runs May 13-17, 2018 in Sydney.
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Dion Lee: Women's and Men's Autumn/Winter 2020/21 show in New York (with interview)


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Residence LaRò – how to find us!
Leave the A22 motorway at the Brixen – Pustertal junction and follow directions to Bruneck / Pustertal. After 40 km, take a right-hand turn at Sankt Lorenzen into the Gadertal Valley and continue for about 30 km to St. Kassian.
The nearest large station with international trains is in Franzensfeste. Regular trains and buses will take you from here to St. Lorenzen – journey time approx. 30 minutes! Let us know your time of arrival – we are happy to collect you from the station!
From January to April, visitors from the Ruhr area (c. 30 different pick-up points) can travel to Alta Badia in comfortable coaches. The coach departs 7pm on Friday and arrives Saturday morning (approx. 9am), after a comfortable overnight journey. The return journey from Alta Badia departs on Saturday evening (approx. 6pm).
We look forward to welcoming you to Residence La Rô and offering you an unforgettable holiday in Alta Badia!