VICTOR OCEAN FISH formula with Wild Alaskan Salmon uses fish as the primary protein source, providing an excellent balance of amino acids as well as high levels of the much desired Omega 3 fatty acid.
This is naturally formulated dog food containing added vitamins and minerals and other additives that work together to support a strong immune and digestive system. As with all Victor dog foods, this formula is free from Corn,Wheat,Soy or Glutens and is also made using wholesome grains! This nutritionally balanced food is formulated for All Life Stages.
This is naturally formulated dog food that is free from Corn, Wheat, Soy, and Gluten. The absence of processed grain by-products results in increased digestibility and reduced stool volumes.
This is naturally formulated dog food containing added vitamins and minerals and other additives that work together to support a strong immune and digestive system. As with all Victor dog foods, this formula is free from Corn,Wheat,Soy or Glutens and is also made using wholesome grains! This nutritionally balanced food is formulated for Maintenance.
Formula for Active Dog & Puppies. Contains high levels of proteins and energy with only 30% carbohydrates! This super premium dog & puppy food is naturally formulated with added vitamins, minerals and other additives that work together to support a strong and healthy immune and digestive system.
Food featuring high levels of protein and energy with only 30% total Carbohydrates. This is an excellent choice for young, growing and highly active dogs of all ages. Multiple protein sources from Beef,Pork, and Chicken (Meals) provide excellent amino acid balance supporting muscle development and maintenance.
Formula has been used for years by professional dog breeders, kennels as well as owners of active sporting dogs. This is a food that works for Lactating Females, Puppies, Growing and Highly Active Dogs. A true high protein / low carb All Life Stages formula.
Formula is an excellent choice for Highly Active Sporting Dogs.This no Corn,Wheat, Soy or Gluten formula is also free from processed grain by-products such as Rice Bran,Wheat Midds etc.
Our Heavy-Duty Super Spear is designed for the heaviest of round bale lifting. Featuring a heavy-duty replaceable heat-treated upper spear and 2 lower welded stabilizer bars for extra hold, this spear hooks to most any Category I 3-point hitch. Category I pins are included with purchase. This product features our durable, corrosion-resistant powder coat gray.
The heaviest bunk feeder on the market, this tough Metal Grain Feeder is constructed of 14-gauge steel with heavy-duty legs. The tapered bottom provides for easy flow and holes drilled in the bottom of each end provide for drainage. Pre-drilled holes on each end of the feeder allow for multiple feeders to be joined together for continuous bunks. The units are fully stackable. Available in powder coat red only.
The Tarter 2-Piece Heavy-Duty Slant Bar Hay Feeder is ideal for feeding round bales to cattle. The 8' diameter accommodates large bales and the slants are welded for extra strength. This feeder is built to withstand abuse. Not recommended for feeding horses.
Easily and humanely cinch up a horse more securely the first time, every time with the exclusive Smart Cinch®. This straight cinch is made from nylon and neoprene with the patented Roll Snug® Cinch Buckle. Shock-absorbing neoprene is easy-to-clean, withstands the elements, and moves with the horse. Webbing detaches from neoprene for easy cleaning. Nylon off billet holder. Stainless steel buckles and dees.
Rack Explosion is a deer mineral supplement plus vitamins A,D, & E. It was created to improve the health of all deer, and enhance antler size to maximum potential.
The SpyPoint FL-8 infrared game camera captures 8.0-megapixel color photos by day and black-and-white at night and 10 to 90 sec. videos with sound. The flash unit allows the capture of full color pictures even at night. The FL-8 uses high-power LEDs to take correctly exposed images in stunning clarity. The FL-8 camera is also compatible with SpyPoint REMOS™ technology.
Persist orchardgrass is one of the most exciting forage grasses of our time. It has unmatched persistance, very high yields and a very special history. Persist is easily established and has excellent seedling vigor. Use of white clover or other legumes can also increase persistence and yield.
elected for its improved traits and ease of establishment in lawns, Fescue Kentucky 31 is guaranteed to produce a fresh, light green color. Ideal for the average lawn use, Fescue KY is coarse in texture. Comes in a convenient 50lb bag and is easy to spread.
A premium formulation of Deer Cane® with more minerals and flavor attractants that requires no mixing and begins instantly attracting deer. Once placed on the bare ground, Black Magic© starts immediately releasing magical vapors to lure deer into the beneficial mineral site.
Equimax® is the only combination ivermectin/praziquantel dewormer safe for ALL horses, including foals four weeks of age and older, pregnant and lactating mares, and breeding stallions. Treat and protect your horse from the most common parasitic threats with one safe, effective, apple-flavored parasite & tapeworm control compound.
Vetericyn Wound and Skin Care is intended for the OTC management of skin abrasions, lacerations, minor irritations, cuts and intact skin. Safe for use on all animal species. 16 oz. liquid (trigger).
Honor® Show Chow® Impact® Club Calf is designed to be fed to starting and growing show cattle. Impact Club Calf is a REGIONAL product and is not available in all markets nationally.
Eagle Valley Talon ABM is an animal bedding material manufactured from 100% Northwest White Pine with approximately 4% moisture content. This makes our product more absorbent than traditional wood shavings, crumbled newspaper or corncob materials.
Lightweight Irish Setter Havoc Big Game hunting boots are built for long-lasting comfort. Hunters will notice the FlexLock handsewn construction which provides flexibility and out-of-the-box comfort over time and miles.
Sure Pick by Callaway Farms is a specialty pine bedding custom manufactured to achieve a mid flake profile for easy cleaning. Preferred by horse owners, Sure Pick bedding produces minimal waste and will last longer in the stall. A compressed 2.44cu' poly bag will expand to 7.5+cu'.


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COVID-19 emergency leave extends through January for county employees
Mike Emery
Richmond Palladium-Item
RICHMOND, Ind. — Wayne County employees exposed to or diagnosed with COVID-19 may use up to 10 days of emergency paid sick leave this month under certain circumstances.
The Wayne County Board of Commissioners approved a policy through Jan. 31 after the federal Families First Coronavirus Response Act ended Dec. 31. The vote was unanimous, and commissioners will revisit the issue prior to month's end.
Kim Clauser, director of the county's human resources department, presented the issue to commissioners Wednesday. She said four county employees already would qualify for the sick leave less than a week into the year, and a post-holiday spike in cases is expected.
►RELATED: Wayne County vaccination clinic begins Monday for ages 80 and older
"For a short period of time, I don't see this as being a hardship," Clauser said of the policy.
The extension will only apply to county employees who quarantine after being exposed to or diagnosed with COVID-19. Also, employees are only eligible for the emergency paid days once, so any employee who has already used 10 days will not be eligible this year.
The extension does not completely replicate the expired act, however. The paid sick leave does not apply to employees needing to supervise children home from school or assist family members impacted by the novel coronavirus.
It also does not provide a work-at-home option.
Clauser said her department has about 150 files involving county employees and the Families First Coronavirus Response Act since April 1.
Sheriff's vehicles
The commissioners Wednesday also authorized Sheriff Randy Retter to pursue the purchase of eight Dodge Durango police vehicles.
Retter has located a dealer with 2020 vehicles in stock that can be purchased at 2020 prices. The sheriff's department's needs to purchase eight vehicles during 2021 to implement a rotation plan.
The 2021 budget allocated $150,000 this year for vehicle purchases, so Retter will need to approach Wayne County Council for additional funding. He said his agency could pay for one vehicle from commissary funds.
The county has begun to collect data from a fleet maintenance program to analyze whether leasing or purchasing county vehicles is preferable. Commissioners opted to authorize Retter's purchase at the lower 2020 prices and continue the discussion this year about whether to lease or purchase vehicles moving forward.
Paust still president
Ken Paust will continue serving as president of commissioners during 2021. He was unanimously approved as president Wednesday.
Paust was elected to the District 1 seat in 2006 after previous service on Richmond Common Council and Wayne County Council.
Mary Anne Butters was unanimously chosen vice president. She was elected to the District 2 seat in 2012.
Paust later welcomed Jeff Plasterer to the Board of Commissioners. Plasterer was elected to the District 3 seat. He replaces Denny Burns, who did not seek a fourth term.
Plasterer served 22 years on the county council, including last year as president.
© 2021 www.pal-item.com. All rights reserved.

redpajama_set_name: RedPajamaCommonCrawl


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Sto Brings Acoustic Balance To A Major London Landmark
The main lobby and Mezzanine Club area of The Stratford (formerly Manhattan Loft Gardens) have been fitted with the StoSilent Distance Acoustic system, to create interiors which balance comfortable acoustic surroundings with a clean and contemporary appearance. Photography: ©Hufton+Crow
A major new landmark on the London skyline now benefits from a balanced acoustic environment thanks to the use of the StoSilent Distance system from Sto. The main lobby and Mezzanine Club area of The Stratford (formerly Manhattan Loft Gardens) have been fitted with StoSilent Distance, to create interiors which balance comfortable acoustic surroundings with a clean and contemporary appearance.
Situated in the heart of London's East End, The Stratford is a prestigious project which features a double-cantilevered 42-storey tower design, and houses 248 residential loft apartments, two restaurants, sky gardens and a 146-room hotel. The high-profile nature of this project dictated that the architects, Skidmore Owings & Merrill, combined outstanding design with high-quality materials wherever possible. "In designing The Stratford, we considered the reasons that Londoners were more interested in living in historic buildings, in Georgian and Victorian architecture", said Kent Jackson, Design Partner at SOM. "Why couldn't new buildings be as interesting, spatially and architecturally, and give you that same type of character?"
Sto's Acoustic Technical Consultant, James Gosling also explains, "there are acoustically challenging areas in most buildings as they usually involve a considerable volume of noise being generated, in large open spaces, by foot traffic and speech". "Attenuating that noise to a level where conversations are possible at normal volumes is an essential requirement if those spaces are to operate smoothly and efficiently."
The StoSilent Distance system allows architects and interior designers to create efficient sound-absorbent walls and ceilings in situations where they must be suspended to reduce room height, accommodate services or to achieve a certain visual appearance. It can be used to create seamless surfaces of up to 200m², including inclined planes or curved vaults, along with sharp joints and creases wherever they are required. The system has a very high degree of resistance to cracking, and includes options which allow it to accommodate both air movement requirements, plus humid and damp conditions.
"This was an involved project as the StoSilent Distance system had to cover quite a large area and allow bespoke artwork and light pendants to suspend from the ceiling," adds Robert Austin of Alpine Finishing, who installed the acoustic treatment. "Although this required the use of a small number of expansions joints, we were still able to create large expanses of clear, seamless surfaces which contribute to the contemporary appearance of the building's interior."
For this project, the StoSilent Distance system was finished with a grey-tinted StoSilent Decor M sound-permeable coating, which complements the overall appearance of the treated areas. This solvent and plasticizer-free finish is spray-applied to create an attractive fine-stipple surface and can be tinted to match a wide range of shades from the StoColor system. It is easy to refurbish, environmentally friendly, inert and natureplus® approved.
StoSilent Acoustic Systems
Go to Project Page
Skidmore Owings & Merrill
Alpine Finishing


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Kanye West Styled Kim Kardashian For System Magazine, So Does This Make Him A Part-Time Stylist, Too?
By Danelle A. Sandoval
Kanye West just keeps branching out beyond music. For his latest gig, Kanye West decided to style Kim Kardashian for a System Magazine shoot in France and it actually looks pretty amazing. While near the Château d'Ambleville, Kim posed in what appears to be lingerie, in an all-natural setting. A pretty interesting theme for a photo shoot, might I say. However, we all know that Kim and Kanye make the boldest fashion statements, whether it be Kim dying her hair platinum blonde, or the debut of Kanye's Adidas Fashion Show. But this, well this is definitely a first in Kimye history.
Speaking of platinum blonde hair, it seems that this shoot was taken a while ago, during their rendezvous in Paris. Looking back at these pics, I actually really miss Kim K's platinum hairdo, don't you? In any case, Kim looks great, like always. This time, it's all thanks to Kanye. Does this mean more style opportunities will arise for Mr. West?
According to The Cut, the shoot is supposed to be, "in an exclusive booklet titled Kanye, Juergen and Kim ." The photos were taken by photographer Juergen Teller.
The Cut said that the booklet will be available on the magazine's website in London this Saturday at IDEA Books, and New York's outpost on July 18.
Well, well, well. We'll just have to wait and see the rest of Kanye's styling skills. But so far, I like what I see.


What Happens When You Get A DUI For The Second Time In California?
Every California motorist already knows that driving under the influence is illegal in this state, and most motorists also know that anyone who is arrested and convicted of DUI will face serious, extensive consequences, even if the conviction is for a misdemeanor first DUI offense.
However, if a driver has been convicted of driving under the influence in California at any point in the previous ten years, or if a driver entered a guilty plea to a wet reckless charge to avoid a DUI conviction at any time in the previous ten years, another driving under the influence incident will be treated as a second offense, and this time, that driver will face harsher penalties.
For most drivers in California who are convicted of driving under the influence, a DUI conviction is a single, isolated event, and it doesn't happen again.
However, repeat offenders still account for approximately 27 percent of the DUI arrests in this state.
The law in California presumes that repeat DUI offenders should face harsher punishments, and those penalties become incrementally harsher with second, third, and subsequent driving under the influence convictions.
This state's judges, law enforcement authorities, and legislators are forever seeking new and more effective methods of deterring and penalizing repeat DUI offenders.
Contacting an experienced Orange County DUI defense attorney is the first move to make for anyone who is charged with driving under the influence in Southern California, whether it is a first offense or a subsequent DUI charge.
WHAT ARE THE PENALTIES FOR SECOND DUI CONVICTIONS IN CALIFORNIA?
A second DUI conviction in California within ten years of a first DUI or "wet reckless" conviction is punishable by a jail term ranging from 96 hours (the mandatory minimum for a second DUI conviction) up to a year in jail and a fine ranging from $390 (also the mandatory minimum for a second DUI conviction) to $1,000.
In lieu of a fine, jail time may be served or community service may be performed. The convicted offender will be placed on probation for three to five years, his or her driver's license will be suspended for up to two years, and the court may order 18 to 30 months of attendance in DUI education classes.
Those are the criminal penalties for a second driving under the influence conviction. California also imposes "administrative" DUI penalties that are entirely separate from the criminal justice process. Anyone facing a second or subsequent DUI charge already knows about the role played by the California Department of Motor Vehicles (DMV) after a driving under the influence arrest.
When a driver is arrested for DUI in California, the arresting officer fills out paperwork (the "Officer's Statement-Admin Per Se") that informs the Department of Motor Vehicles, which automatically suspends that driver's license unless he or she requests, within ten days, a license suspension hearing before the DMV.
To retain your driver's license in Southern California after any driving under the influence arrest, it is imperative to obtain legal counsel immediately, because you have only ten days to request and prepare for a hearing. An Orange County DUI defense attorney can request the DMV hearing and advocate there on your behalf.
WHAT HAPPENS AFTER THE DMV HEARING?
At the conclusion of the DMV hearing, a DMV hearing officer considers the matter and then issues a written decision, which is mailed to the defendant within thirty days.
Even if the Department of Motor Vehicles decides not to suspend a driver's license, that license could still be suspended as a "criminal" penalty rather than an "administrative" penalty if the defendant is convicted of driving under the influence in the criminal case.
Anyone who is convicted of a third DUI offense within ten years in California will serve a minimum of 120 days in jail, but a judge has the discretion to make that jail term a full year.
The state's Department of Motor Vehicles may suspend the driver's license for up to three years.
Other penalties for a third California driving under the influence conviction include fines and fees that can total $3,000 or more.
After completing the jail sentence, the offender will be on probation for three to five years and will additionally be ordered to participate in an 18- to 30-month alcohol treatment program.
The fourth driving under the influence offense in California in a ten-year period is a felony punishable upon conviction by three years or more in a California state prison and a $10,000 fine.
Every DUI case is different. The sentencing standards and practices are complicated and vary from jurisdiction to jurisdiction within the state.
Where the law specifies a mandatory minimum jail term, some prosecutors routinely ask the court for more jail time for convicted offenders.
On the other hand, some DUI offenders serve less time in jail based on credits for exhibiting good behavior or participating in a jail work program.
WHAT HOPE DO YOU HAVE IF YOU FACE A SECOND DUI CHARGE?
California authorities want drivers to "learn a lesson" from a first DUI conviction so that those drivers do not become repeat DUI offenders.
More than seven out of ten California drivers convicted of a first offense DUI do learn that lesson and are never charged with driving under the influence again.
Everyone is capable of making a mistake once. But if a driver is charged with his or her second or third DUI in Southern California, that driver must obtain the advice and services of an Orange County DUI defense attorney.
A second driving under the influence conviction is a genuine threat to anyone's finances, freedom, and future.
But even if you face a second or third driving under the influence charge in California, there's hope. An arrest is not the equivalent of a conviction, and the prosecution still has the burden of proving a defendant's guilt beyond a reasonable doubt.
Every day the courts are open in this state, good DUI lawyers are succeeding on behalf of their clients, having DUI charges dropped or reduced and winning acquittals for defendants.
If you face any driving under the influence charge in this state, make certain that you have an experienced DUI attorney protecting your rights and fighting for justice on your behalf.


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La Maja – obraz olejny namalowany przez Waldo Saavedrę w 2000 roku.

Głównym motywem obrazu jest postać ówczesnej dziennikarki Letizii Ortiz w prawej połowie płótna, przedstawionej w długiej, białej spódnicy, przepasanej czewnoną szarfą i nagiej od pasa w górę. Letizia Ortiz patrzy w stronę widza, a w wyciągniętych rękach ma płonący papierowy samolot. Jej postać jest otoczona drobnymi detalami tła, w tym m.in. motywami z Tauromachii Goi i postacią Fridy Kahlo. Tytuł obrazu La Maja nawiązuje do obrazów Goi Maja naga i Maja ubrana.

Od czasu powstania obraz był wystawiany w wielu miastach.

Przypisy

Portrety

redpajama_set_name: RedPajamaWikipedia


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New Jersey Governor to End School Mask Mandate in a "Huge Step Toward Normalcy" as lawmaker wants a complete ban on all vaccine requirements
Gov. Philip D. Murphy of New Jersey, a Democrat who has imposed some of the nation's most stringent pandemic-related mandates, will no longer require students and school employees to wear masks, signaling a deliberate shift toward treating COVID-19 as a part of daily life.
Murphy, the vice chairman of the National Governors Association, said on Sunday (Feb. 6) that he would officially announce the elimination of the mandate on Monday (Feb. 7) afternoon.
Gov. Murphy to end school mask mandate for N.J. next month, report says https://t.co/jxG5RHBmWN pic.twitter.com/xfcaMJcCDO
— njdotcom (@njdotcom) February 7, 2022
The new policy will take effect the second week of March, two years after New York and New Jersey became early epicenters of COVID-19.
The move follows a decision last month by the Democratic governor of Pennsylvania, Tom Wolf, to rescind his state's school mask mandate. The Democratic governors of New York and Connecticut also said last week that they were re-evaluating school mask mandates that are soon set to expire.
NJ lawmaker wants a complete ban on all vaccine requirements
Some New Jersey concert venues, restaurants, breweries and other locations now require proof of vaccination to enter the facility.
One Garden State lawmaker is pushing a plan to ban this kind of requirement, or any kind of vaccine passport completely.
State Sen. Edward Durr, R-Gloucester, has introduced legislation, S-831 that prohibits a person or any kind of entity from requesting or requiring personal health information pertaining to any individual.
Employees of New Jersey hospitals, nursing homes, prisons and jails will be required to be fully vaccinated against the coronavirus — with a booster — or risk losing their jobs, Gov. Philip D. Murphy announced on Wednesday.https://t.co/5LHUuC4XZw
— NYT Metro (@NYTMetro) January 19, 2022
The lawmaker, who ousted former State Senate President Steve Sweeney, said whether you want to be vaccinated against COVID is a personal choice.
"Clearly you are being discriminated against because of your health status when you're told you can't enter a building because you haven't got the vaccine," he said.
Durr said his bill is sort of the flip side of HIPAA, the Health Insurance Portability and Accountability Act.
"HIPAA works where agencies aren't allowed to give out your information. This prevents an agency from asking. It's basically a privacy bill," he said.
None of my business, he says
"I'm about personal choice. This isn't any different than if somebody wants to smoke cigarettes and drink alcohol, do damage to their liver or their lungs, that is a personal choice that does not affect me," he said.
He also said during the recent omicron surge we learned the vaccine does not prevent you from testing positive or transmitting the virus.
According to updated guidance from the Centers for Disease Control and Prevention, "getting vaccinated against COVID-19 can lower your risk of getting and spreading the virus that causes COVID-19. Vaccines can also help prevent serious illness and death."
Durr said he doesn't have a personal issue with Phil Murphy when it comes to COVID rules and regulations but "I feel that the governor is either following bad advice or getting bad advice — one way or the other things need to be put back in the people's hands."
He added he expects lawmakers from both sides of the aisle to support the measure because getting a vaccine is a personal choice and denying someone their basic rights because of that choice should not be allowed.
"It's a form of discrimination and I don't think anybody can approve of discrimination," Durr said.
The bill prohibits entities from discriminating in the provision of goods, services, or other benefits against a person who declines to provide personal health information.
The restrictions established under Durr's bill do not apply to a health care professional directly or indirectly providing physical or mental health care services or when federal law expressly authorizes the information to be requested or required.
Read More: NJ lawmaker wants a complete ban on all vaccine requirements | https://nj1015.com/nj-lawmaker-wants-a-complete-ban-on-all-vaccine-requirements/?utm_source=tsmclip&utm_medium=referral


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Diocese News June 4, 2020
A Reflection for Pentecost by Bishop Greg Kelly
"We listened and we prayed together, sometimes on our knees, sometimes with our arms extended: Christians and Jews, others as well."
On May 31, as protests occurred throughout the country concerning the death of George Floyd, members of the Dallas faith community gathered for a prayer vigil outside Dallas police headquarters. Among those in attendance were Auxiliary Bishop Greg Kelly and Father Arthur Unachukwu. Bishop Kelly shared the following reflection from the evening:
An image appeared on TV and newspapers and social media platforms: a white Minneapolis police officer kneeling on the neck of an African-American man already in custody. The expression on the face of the officer seemed nonchalant. While a man was dying: George Floyd, repeatedly telling the officers he was unable to breathe, asking for help, calling for his mother. We all know this story now.
There have been so many images of protest and anger and violence, images of people at rallies and at prayer. I attended a gathering for prayer on Sunday evening along with Father Arthur Unachukwu, a service in front of Dallas Police Headquarters, with many Anglo and African-American pastors and faith leaders calling for change, speaking of the change needed on an individual basis, in the heart of each one of us; and change needed on an institutional level: in society, in cities and churches, in all the institutions where the effects and consequences of racism are woven into the fabric of things, often hidden from view.
The long and often forgotten history of racism in Dallas was recalled: a lynching in 1910 on Main Street near the arch welcoming people to the city; Ku Klux Klan Day at the State Fair, said to have always been a well-attended day; the single day reserved each year for African-Americans, who were excluded every other day until the 1960s. And the litany of names so familiar, ending with George Floyd — which hopefully will be the last one on that long list.
We listened and we prayed together, sometimes on our knees, sometimes with our arms extended: Christians and Jews, others as well. We prayed as brothers and sisters, struggling to be brothers and sisters, asking for the guidance of the Holy Spirit to be brothers and sisters: to do right, to love justice, and to walk humbly with our God—and with one another, not only in that moment but more importantly in the days and weeks ahead. This familiar passage from Micah 6:8 invoked in the prayer service was also invoked in the US Bishops recent Pastoral Letter on Racism: Open Wide Our Hearts: The Enduring Call to Love .
Catholics were not present in great numbers as far as I could tell. I felt sorrow at this, also a sense of hope, that it was time to do something new, and that the Lord would lead us into that. Sunday was the celebration of the feast of Pentecost, the coming of the Spirit on the apostles in the upper room, the whole church gathered together and sent out to the world, the same Spirit given to all for the preaching of the gospel. We all came from that, even with all the divisions and sinfulness among Christians. The effects of that Spirit were evident in the ministers who spoke: white and black, male and female, all spoke with courage and passion and hope that we could be better, as a city and a church.
In the days between the Ascension and Pentecost, as the disciples gathered and prayed, Mary prayed with them. The bishops ended their letter with a prayer for her intercession. It is a good place to end this reflection:
Mary, friend and mother to all, through your Son, God has found a way to unite himself to every human being, called to be one people, sisters and brothers to each other. We ask for your help in calling on your Son, seeking forgiveness for the times when we have failed to love and respect one another. We ask for your help in obtaining from your Son the grace we need to overcome the evil of racism and to build a just society. We ask for your help in following your Son, so that prejudice and animosity will no longer infect our minds or hearts but will be replaced with a love that respects the dignity of each person. Mother of the Church, the Spirit of your Son Jesus warms our hearts: pray for us.
Source: TexasCatholic.com
Image Source: @chancehorner on Twitter
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ScienceCover
A new study shows how spike protein crosses the blood-brain barrier
Imaging method reveals a "symphony of cellular activities"
Memories create 'fingerprints' that reveal how the brain is organized
Commonly used antibiotic shows promise for combating Zika infections
NASA Approves Heliophysics Missions to Explore Sun, Earth's Aurora
White house releases national strategy for planetary protection
Primordial black holes and the search for dark matter from the…
Exoplanet around distant star resembles our reputed 'Planet Nine'
NASA Moves Forward With Campaign to Return Mars Samples to Earth
Quantum wave in helium dimer filmed for the first time
New type of atomic clock keeps time even more precisely
New microscope technique reveals details of droplet nucleation
Game changer in thermoelectric materials could unlock body-heat powered personal devices
Two distinctly different liquid states of water
Ultrasensitive transistor for herbicide detection in water
AI reduces computational time required to study fate of molecules exposed…
Lower current leads to highly efficient memory
Home Medicine A new MIT study analyzes viral contamination at biopharmaceutical manufacturing plants
A new MIT study analyzes viral contamination at biopharmaceutical manufacturing plants
Report offers guidelines to help prevent viruses from tainting biopharmaceutical drugs
Deleep
Over the past few decades, there have been a handful of incidents in which manufacturing processes for making protein drugs became contaminated with viruses at manufacturing plants. These were all discovered before the drugs reached patients, but many of the incidents led to costly cleanups and in one instance a drug shortage.
A new study from an MIT-led consortium has analyzed 18 of these incidents, most of which had not been publicly reported until now. The report offers insight into the most common sources of viral contamination and makes several recommendations to help companies avoid such incidents in the future.
While the study focused on biopharmaceuticals (protein drugs produced by living cells), the findings could also help biotech companies to create safety guidelines for the manufacture of new gene therapies and cell-based therapies, many of which are now in development and could face similar contamination risks.
"As the biotech industry starts to think about manufacturing these really exciting new products, which are highly effective and even in some cases curative, we want to make sure that the viral safety aspects of manufacturing them are considered," says Stacy Springs, senior director of programs for MIT's Center for Biomedical Innovation (CBI).
Springs is the senior author of the study, which appears today in Nature Biotechnology. Paul Barone, director of the Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB), is the lead author. The other authors from CBI are Jackie Wolfrum, who with Barone is co-director of CBI's Biomanufacturing Program, as well as Michael Wiebe and James Leung, who worked on the study with industry experts from the CAACB.
Many therapeutic proteins are produced using recombinant DNA technology, which allows bacterial, yeast, or mammalian cells to be engineered to produce a desired protein. While this practice has a strong safety record, there is a risk that the cultured mammalian cells can be infected with viruses. The CAACB, which performed the study, was launched in 2010 following a well-publicized contamination incident at a Genzyme manufacturing plant in Boston. The plant had to shut down for about 10 months when some of its production processes became infected with a virus in 2009.
When such incidents occur, drug companies aren't required to make them public unless the incident affects their ability to provide the drug. The CBI team assembled a group of 20 companies that were willing to share information on such incidents, on the condition that the data would be released anonymously.
"We thought it would be very valuable to have industry share their experience of viral contamination, since most companies have had none of these incidents if they're lucky, or maybe one or two at the most," Springs says. "All of that knowledge about how they discovered and managed the event, identified the virus and its source, disinfected and restarted the production facility, and took action to prevent a recurrence was all siloed within individual companies."
The study, which focused on protein drugs produced by mammalian cells, revealed 18 viral contamination incidents since 1985. These occurred at nine of the 20 biopharmaceutical companies that reported data. In 12 of the incidents, the infected cells were Chinese hamster ovary (CHO) cells, which are commonly used to produce protein drugs. The other incidents involved human or nonhuman primate cells.
The viruses that were found in the human and nonhuman primate cells included herpesvirus; human adenovirus, which causes the common cold; and reovirus, which can cause mild gastroenteritis. These viruses may have spread from workers at the plants, the researchers suggest.
In many cases, contamination incidents were first detected because cells were dying or didn't look healthy. In two cases, the cells looked normal but the viral contamination was detected by required safety testing. The most commonly used test takes at least two weeks to yield results, so the contaminating virus can spread further through the manufacturing process before it is detected.
Some companies also use a faster test based on polymerase chain reaction (PCR) technology, but this test has to be customized to look for specific DNA sequences, so it works best when the manufacturers know of specific viruses that are most likely to be found in their manufacturing processes.
"This work demonstrates how sharing of data and information yield better understanding of difficult problems in manufacturing biologics," says Janet Woodcock, director of the Center for Drug Evaluation and Research at the FDA, who was not involved in the study. "Innovators contemplating new processes or product may be able to avoid pitfalls or disasters by learning from the collective past experiences documented here."
Many of the CAACB member companies are exploring new technologies to inactivate or remove viruses from cell culture media before use, and from products during purification. Additionally, companies are developing rapid virus detection systems that are both sensitive and able to detect a broad spectrum of viruses.
CBI researchers are also working on several technologies that could enable more rapid tests for viral contamination. Much of this research is taking place within a new interdisciplinary research group at the Singapore-MIT Alliance for Science and Technology (SMART), called the Critical Analytics for Manufacturing Personalized Medicines. Led by Krystyn Van Vliet, MIT associate provost and a professor of biological engineering and materials science and engineering, this group, which includes several other MIT faculty members from across departments, is working on about half a dozen technologies to more rapidly detect viruses and other microbes.
"I think that there's a lot of potential for technology development to ameliorate some of the challenges we see," Barone says.
Another strategy that the report recommends, and that some companies are already using, is to reduce or eliminate the use of cell growth medium components that are derived from animal products such as bovine serum. When that isn't possible, another strategy is to perform virus removal or inactivation processes on media before use, which can prevent viruses from entering and contaminating manufacturing processes. Some companies are using a pasteurization-like process called high temperature short time (HTST) treatment, while others use ultraviolet light or nanofiltration.
The researchers hope that their study will also help guide manufacturers of new gene- and cell-therapy products. These therapies, which make use of genes or cells to either replace defective cells or produce a therapeutic molecule within the body, could face similar safety challenges as biopharmaceuticals, the researchers say, as they are often grown in media containing bovine serum or human serum.
"Having done this sharing of information in a systematic way, I think we can accelerate the dissemination of information on best practices, not only within the protein manufacturing industry but also the new industry of cell-based modalities," says James Leung.
The study was published Massachusetts Institute of Technology
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Click here to see all of the amazing items we will have at our Silent Auction tomorrow!! Pick up a Bid Number in the Cafe at the "Bid Number Assignment" table! The Silent Auction will close at 7:15 p.m. sharp! All proceeds will benefit our amazing staff and student supported programs at Crooked Creek! See you there!
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View All American Dream Patriot Class B Motorhome Floorplans!
Nate: And we're here to show you the brand new American Dream Patriot.
All right, Jayne, so we are looking at the American Dream Patriot. And what makes the Patriot brand unique?
Jayne: Well, first of all the Patriot is new to the American Coach lineup. And the neat thing is for years American Coaches have all been 42-feet or longer. We're seeing an emerging market now of people who are your age and my age, and people who have kids who want to park this in their driveway at home and not have to store it somewhere, but still be able to get out and go to travel soccer games and do all that fun stuff with their family, but not have to go somewhere and get it out of storage to go.
Nate: Why is it special?
Jayne: Well, the cool thing is number one this is very affordable. For not too terribly much more money than you might go buy a new Chevy Suburban for, you can be into something like this that has a shower in it, a bathroom in it, be able to watch TV in it, be able to get up and move around when you're going down the road, cook in it. But the really neat thing about it is unlike other class B's that are out there, when you're inside this you feel like you're in a high-end luxury car, not necessarily in your traditional RV that you might have in mind that your grandparents own.
Nate: What are your top three favorite features in the Patriot?
Jayne: It's hard to pick three, but speaking from somebody who drove one of these for 3,400 miles in 11 days I totally got sold on this Coach for a couple of reasons. Number one it is the quietest Class B on the market.
Number two I would say my second favorite thing is just the whole Class B compact size, but kind of go a little bit step further with the wood that we do. Nobody else is doing this kind of wood in a Coach, it's what lends itself to that feel that high-end luxury automobile inside.
And number three I would say one thing that we do that nobody else does is we coordinate our dash panels and our door panels with the same color that's inside the Coach. So everybody else out there in the marketplace basically uses a standard gray that comes from the OEM. We take those panels off, and we color code it to match the inside of the Coach.
Nate: Jayne, if you'd like to check out the American Patriot you can head over to rvingplanet.com.


text:
CEOWORLD magazine - Top Stories - Big Picture - Most Violent Cities In The World
Most Violent Cities In The World
Anna SiampaniBig Picture April 15, 2022
Outside of active war zones, there are some cities that seem to have traditionally been involved with crime. Usually, big cities, where criminals can hide behind a large mass of people are the most popular destinations for groups of criminals that act in an organized way, as well as individuals who know that they are less likely to deal with the law for their illegal actions and activities. At the same time, poverty comes to add another reason to cause people to act violently. However, this is not a rule. There are places where even though people do not share the goods that the high class can enjoy they do not turn to crime. In the list of the world's most dangerous cities, you will see that Latin America and Africa dominate. Asia may have poor places but the population has a more peaceful attitude, perhaps due to the religious background and the overall culture. Tourists and travelers who may leave their countries for business or pleasure need to have a clue.
Here is a list of the most violent cities:
Tijuana, Mexico
Tijuana is on the west side of North Mexico bordering the United States. The borders of this country had always been an issue. Some years ago it was Ciudad Juarez, now it is Tijuana. A lot of the criminal activity has to do with drug trafficking. Gangs try to dominate each other taking innocent lives along the way. As lovely as this sunny place maybe it is probably preferable to stay on the other side of the border in the United States. San Diego in the USA is equally beautiful and it is a super safe place to walk around. Besides, the roads are clean and many fun things to do can keep you busy while you enjoy your stay.
Caracas in Venezuela and Tijuana in Mexico, have been competing over which city will push things to the edges more. Again drugs are a big industry here. Many people are being involved around it and only the homicides three years ago were close to 3.000! Well, capital of Venezuela and capital of murder as well. The "barrios," small and poor neighborhoods are rarely patrolled by police and you shouldn't consider paying a visit to see what real life in Venezuela looks like. It is better to stay at tourist places and walk around in the daytime.
Rio de Janeiro together with El Salvador is extremely dangerous. In 2014 Brazil hosted the Mundial after South Africa in 2010. In an attempt to make the city look nice for the tourists, the government spends enormous amounts on construction in the center leaving other areas starving to death. The problem came as an addition to the extreme poverty population suffered already. Life completely lost its value in the big city and locals turned to crime even more. Tourists and people from other countries were always an easy catch. Not because no one would search for them but because they were less suspicious and prejudiced against locals.
Pietermaritzburg, South Africa
South Africa carries a sad history of violence. Europeans have taken advantage of the country's population in the past and hate has grown against those who mistreated them and in many cases, they still do. It may sound crazy but racism across South Africa is an existing issue. Pietermaritzburg and Pretoria are among the world's most violent cities. For the locals, apart from the fact that foreigners worth to be robbed and maybe killed because they are likely to carry a considerable amount of money in their pockets being violent to them will not cause great issues. Police will get them in trouble, but they will not have to deal with other locals from different gangs, which is the most crucial that in their case. The scenery reminds also civil war as there are gangs that attack tourists at night while they are being armed. If you don't spend your time at the tourist spots it is better to walk with locals who you trust to have some security and avoid wandering around along
Tags :Business Leaders InsiderChief Behavioral Officer InsiderChief Budget Officer InsiderChief Ecosystem Officer InsiderChief People Officer (CPO) InsiderCo Founders Insider
Anna Siampani April 15, 2022
Anna Siampani
Anna Siampani, Lifestyle Editorial Director at the CEOWORLD magazine, working with reporters covering the luxury travel, high-end fashion, hospitality, and lifestyle industries. As lifestyle editorial director, Anna oversees CEOWORLD magazine's daily digital editorial operations, editing and writing features, essays, news, and other content, in addition to editing the magazine's cover stories, astrology pages, and more. You can reach Anna by mail at anna@ceoworld.biz
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text:
Aletta Brady '15 talks to Joe McCarthy and Peter Albano about MiddletownRemix Festival (May 11)
May 3, 2013 April 29, 2013 by abrady
Music & Public Life Intern Aletta Brady '15 talks to photographer and filmmaker Joe McCarthy and woodcut artist, bookbinder, papermaker, and muralist Peter Albano about MiddletownRemix: Hear More, See More – A Festival of Art and Sound, taking place on Saturday, May 11, 2013 from 2pm to 5pm. The art/sound installation "Camera Obscura," a temporary 16′ X 8′ "camera" commissioned for the festival, will be installed on the corner of Main Street and Grand Street by Mr. McCarthy and Mr. Albano. The installation will also be featured outside of the Usdan University Center at 45 Wyllys Avenue the week leading up to the festival, from Monday May 6 through Thursday, May 9, 2013.
Photographer and filmmaker Joe McCarthy (left) and woodcut artist, bookbinder, papermaker, and muralist Peter Albano (right), working on their art/sound installation "Camera Obscura," commissioned for the MiddletownRemix Festival, taking place on Saturday, May 11 from 2pm to 5pm.
In mid-April, I biked over to Peter and Joe's house after I got off of work at the Center for the Arts. When I arrived, they were out in their backyard working on building their art installation that will be featured at MiddletownRemix: Hear More, See More – A Festival of Art and Sound on Saturday, May 11 from 2pm to 5pm. The installation is titled "Camera Obscura." They happily showed me around the frame of the piece that they were working on, and invited me to join them around their coy pond for our interview.
Peter Albano is a graduate of the University of Hartford Art School where he studied printmaking, and Joe McCarthy studied photography and film in Boston and Los Angeles, before the two of them met in Middletown, and collaborated as artists on the Hog River Revival Project in Hartford. They described their project for the MiddletownRemix festival as "pinhole photography, just on a much larger scale—a pinhole camera that you can walk inside of. The sound element going on will [make it] a full sensory experience inside the camera".
They had a lot of great things to say about the MiddletownRemix festival, and their role in it. Here are some highlights from our conversation:
Aletta Brady '15: Tell me about your art/sound installation "Camera Obscura" that will be displayed at the MiddletownRemix festival.
Joe McCarthy: We started thinking about the idea of creating this soundscape that was basically just taken, much like the [MiddletownRemix] project, from the streets. Nothing really created, more just arranged. And then we thought, "well, what kind of visual can match that sound element?" And, you know, the most bare bones, un-augmented camera is just a simple pinhole lens. There's nothing to focus it, it is what it is, it's just light. It use[s] the visuals from the streets of Middletown that are literally just what's in front of your eyes. Its kind of like removing people from Main Street in order for them to more clearly view Main Street, or more clearly experience Main Street.
Peter Albano: One of the issues that we encountered was incorporating a sound element that highlighted the visual elements, because those are two completely different senses, and we landed on the idea of creating and taking one out of the environment, and that's what the structure to walk into was, rather than any structure you just observe.
Aletta Brady '15: Why were you interested in creating an installation for the MiddletownRemix festival in particular?
Joe McCarthy: I think that we were both really excited that [the festival] is all about Middletown, like two blocks from where we make work, you know? 'Cause the area that you choose to be in definitely has an influence on your work, and this sort of opportunity has allowed that influence to come to the front, which is healthy sometimes.
Conceptual drawing of "Camera Obscura," a temporary 16′ X 8′ "camera," which will be installed on the corner of Main Street and Grand Street during the MiddletownRemix Festival on Saturday, May 11 from 2pm to 5pm.
Aletta Brady '15: Tell me about yourselves as artists and your own personal journeys.
Peter Albano: I come from a much different background technique-wise than Joe. I'm much more of a drawer. I studied printmaking in college. I never dabbled in photography until the Hog River project. What drew me to this project was the scale of it, and the idea of getting it to work, making it work. It's an endeavor. On a more broad scheme, I think most of our work revolves around the idea of highlighting the citizen that passes [and] community involvement. The Hog River project was a Hartford-centric project, and it revolved around the gathering of people and the sharing of information, and I think this project is a nice step up from there.
Joe McCarthy: All of my work, it just is a kind of way for me to break down something that I'm curious about. The subject matter is always on a personal level derived from me trying to reconcile my thoughts about one thing or another. Technically, the work I do has a lot to do with light, and in the Hog River project, that was all about [light], because there wasn't any of it. That kind of became [the "Camera Obscura" project], where you have all the light in the world, and it's all about limiting it and blocking it out and controlling the light.
Aletta Brady '15: What are you most excited about for Saturday May 11, the day of the MiddletownRemix festival?
Peter Albano: The flash mob dance [at 2:30pm in front of It's Only Natural Market at 575 Main Street].
Joe McCarthy: I always get a kick out of being able to stand away from my work and watching how people interact with it, its always fun. Its cool to make something and there's nothing you can do, it's out there now, so all you have to do is just stand back and no one knows like, "oh those are the guys that made it." So you can just stand there and watch someone, or go into the camera with someone, and really just pay attention to how that stranger interacts with this completely new thing to them. Its impossible to be objective. By the end of this camera, neither one of us will be able to say its good or bad, or if it worked or it didn't, 'cause we're way too close to it, so I'm always curious about what the reveal on a finished piece of work is to a clean set of eyes.
For the complete MiddletownRemix festival schedule, and to capture, contribute and remix sounds from Wesleyan and Middletown using the free UrbanRemix app for iPhone/iOS and Android devices, visit http://www.middletownremix.org
Categories Community Engagement, Music, Studio Art Tags Community Engagement, Music, Visual Art Post navigation
Michelle Agresti '14 talks to Ronald Kuivila about MiddletownRemix Festival (May 11)
Michelle Agresti '14 talks to Jason Freeman about MiddletownRemix Festival (May 11)


Camphill Village Kimberton Hills' biodynamic raw milk dairy farm is comprised of mixed pasture, hay and arable land. Located 50 minutes outside of Philadelphia, the dairy sits on 250 acres of their 432-acre Kimberton, Pennsylvania farm. Their crew of up to 10 farmers includes villagers, coworkers, and service volunteers, who form a close-knit team working together to meet the needs of the farm and animals.
This brand's products can be found in Pennsylvania in some grocery chains and small natural foods stores.


Bulk classified and unclassified materials to get rid of? Consider going dual stream.
At SEM, we often hear from folks starting from scratch to plan central destruction programs. One question that comes up is whether to treat all the material the same – one collection program, one destruction device, what is sometimes called single stream destruction.
Single stream destruction requires equipment that can meet the security rules for the most sensitive items. With classified documents in the mix, an NSA listed destruction device is required. Nowadays only one type of machine is practical for bulk classified destruction, namely a knife mill disintegrator. A disintegrator to destroy everything is a frequent choice.
However, there are some things to consider before choosing single stream. In the 150 to 500 pounds per hour destruction rate range, a mid-sized disintegrator can do the job in a fairly small space (say a 12' x 14' room). For throughput beyond that, especially 1,000 pounds per hour and up, disintegrators become more substantial systems, with conveyor feed, output to dumpsters or briquettors, and central control systems. These machines involve more logistics, supervision, and investment.
So, what's an alternative to single stream?
The answer is dual stream destruction, where classified and unclassified materials are handled separately. By splitting them up, the destruction equipment can be smaller, lower cost, and easier to manage. The reason is that it is difficult to destroy material to the very small NSA mandated particle size.
For unclassified materials, the gold standard destruction process is a crosscut paper shredder. These cut small, but not nearly as small as required for classified documents. A common particle size choice is 5/32" x 1 5/32" (about 4 mm x 40 mm metric), often referred to by the European designations "Level 3 or Level P-4". Machines that cut in this size range with high throughput are often referred to as Industrial Shredders. These machines can handle from 150 to 2,000 pounds per hour, depending on the model. Compared to a disintegrator, an industrial shredder fits in a smaller space, makes less noise, requires less service, is more user friendly, and costs less money to purchase and maintain – often much less than ½ the price for the initial investment.
Which method is the right choice? It depends on the situation – the volume and mix of materials, the ability to police the separation of classified and CUI, budget, and more. This decision warrants a careful examination of the options.


text:
Google (GOOGL) Stock Surges Almost 10 Percent in Q2 2019 Earnings
Jul 26 2019 · 10:24 UTC | Updated Jul 26 2019 · 10:25
by Tolu Ajiboye · 3 min read
Google (GOOGL) records almost 10 percent increase in stock for the year's second quarter. The official report also shows 13 percent increase in Traffic Acquisition Cost, hitting $7.24 billion.
On Thursday the 25th of July, Alphabet's (GOOGL) second-quarter earnings report was officially published by the firm. The report showed a $38.9 billion revenue which was about $800 million higher than average expectations from analysts, who predicted $38.1 billion.
Furthermore, analysts predicted about $11.30 as earning per share and this was also surpassed as the Q2 figure came in at $14.21. The report also showed progress with advertising which is credited for pushing the Alphabet's stock past $96, representing an 8.5 percent increase in after-hours trading.
Advertising Specifics
Total revenue for advertising in the second quarter grew from $28 billion and increased by 16 percent to hit $32.6 billion. GOOGL investors reportedly projected a higher increase – up to 20 percent – but the current figures seem to be well accepted. The figure also seemed to show that there was indeed light at the end of the revenue growth tunnel which didn't seem to shine so bright in previous quarters.
For paid clicks, revenue increased by 28 percent when compared with the same period last year but seemed to signify a general comparative drop. This, according to some analysts, means that there might be a growing chance that advertisers who regularly use Google's platform might be increasingly discontented with the value being received.
Traffic Acquisition Costs
According to the reports, the amount used to gather traffic or attract partner websites, saw an increase but was still a little lower than expected. Analysts had forecasted that Traffic Acquisition Costs (TAC) would hit $7.27 billion but was a little off as it increased by 13 percent but only hit $7.24 billion.
Google's TAC history has been increasing recently as there is now a higher dependence on third-party apps and its various partner sites. Google is focusing on this as a major way to improve its mobile advertising revenue.
Worthy of note here is Google Properties. The revenue from its ads and other services including divisions like Gmail, YouTube and Google Play surged by 18% and hit $27.34 billion. This outdid an estimate of $27.14 billion.
Some Legal Trouble
The Federal Trade Commission has officially opened an investigation that accuses Google of some antitrust breaches regarding its advertising. There is also a near-future plan for the Department of Justice to begin a probe of major tech giants, Alphabet being one of the foremost.
During the last quarter, the European Union fined Alphabet a sum of $1.7 billion because the tech giant had allegedly prevented fair opposition in the region's interactive ad sphere.
Analysts generally feel that Google may be quite overvalued. Some figures put this overvaluation at between 50 and 70 percent. It is also said that the current overall market is at its third most expensive period in all of market history.
These two points might seem unconnected but could there be any correlation?
next Business News, Editor's Choice, Internet of Things News, Market News, News
Author Tolu Ajiboye
Tolu is a cryptocurrency and blockchain enthusiast based in Lagos. He likes to demystify crypto stories to the bare basics so that anyone anywhere can understand without too much background knowledge. When he's not neck-deep in crypto stories, Tolu enjoys music, loves to sing and is an avid movie lover.
By Ibukun Ogundare January 31st, 2023
Business News, News, Social Media, Technology News TikTok CEO Set to Appear Before Congress over Concerns about US National Security
TikTok representative Brooke Oberwetter said the company is willing to correct any misapprehension.
By Tolu Ajiboye January 30th, 2023
Business News, Market News, News, Technology News, Transportation News Renault Slashes Nissan Stake as Part of Broader Partnership Restructuring Plans
Renault and Nissan recently announced that the French automaker would transfer 28.4% of Nissan's stake into a French trust.
Currencies, Market News, News, Story of the Day British Finance Minister Calls on Tech Giants to Stoke Growth in Nation amid Reformative Tax Hikes
Finance Minister Jeremy Hunt has implored companies to play a crucial role in British economic growth as the country angles for tax hikes.
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Fishtail Cottage: Cottage Garden Party #14 "
Thanks for hostessing this garden party this week. I'll come back to see who else is joining in.
Enjoy the rest of your week. Thank you for hosting and I look foward to seeing some wonderful blooms.
Thanks for the party, have a great day!
Thank you so much for hosting your garden party. I always look forward to seeing all the beautiful gardens! Have a great week.
So happy to have discovered you and thank you for hosting!
Hello Tracie: Thank you for hosting another great garden party. Have a wonderful weekend--supposed to be a scorcher here in the Pacific Northwest!
Sorry I'm late, but all linked up now. That's for hosting!


One of the latest additions to Shenzhen's skyline, the award-winning Residence G Shenzhen is an extension of the Hotels G brand under the management of GCP Hospitality. Since the opening in March 2017, the hotel's professional team has been led by General Manager Blandine Cressard, who specializes in high-end hospitality management. Blandine Cressard is originally from France and has two Master Degrees to her name along with over 27 years of experience working in hospitality. Blandine joined Residence G Shenzhen at its construction stage and led the team to gain notoriety within two years. As the only female candidate, she stood out from other competitors in the Hotelier Award 2018 assessment and made it into the top three finalists for the title of "Best General Manager" in the Greater China region.


text:
using System;

using FluentAssertions.Common;

#if !OLD_MSTEST && !NUNIT
using Microsoft.VisualStudio.TestPlatform.UnitTestFramework;
#elif NUNIT
using TestClassAttribute = NUnit.Framework.TestFixtureAttribute;
using TestMethodAttribute = NUnit.Framework.TestCaseAttribute;
using AssertFailedException = NUnit.Framework.AssertionException;
using TestInitializeAttribute = NUnit.Framework.SetUpAttribute;
using Assert = NUnit.Framework.Assert;
#else
using Microsoft.VisualStudio.TestTools.UnitTesting;
#endif

namespace FluentAssertions.Specs
{
    [TestClass]
    public class TimeSpanConversionExtensionSpecs
    {
        [TestMethod]
        public void When_getting_the_number_of_days_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Days();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(4, 0, 0, 0), time);
        }

        [TestMethod]
        public void When_getting_the_number_of_hours_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Hours();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(4, 0, 0), time);
        }

        [TestMethod]
        public void When_getting_the_number_of_minutes_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Minutes();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(0, 4, 0), time);
        }

        [TestMethod]
        public void When_getting_the_number_of_seconds_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Seconds();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(0, 0, 4), time);
        }

        [TestMethod]
        public void When_getting_the_number_of_milliseconds_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Milliseconds();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(0, 0, 0, 0, 4), time);
        }

        [TestMethod]
        public void When_getting_the_number_of_ticks_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time = 4.Ticks();

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(TimeSpan.FromTicks(4), time);
        }

        [TestMethod]
        public void When_combining_fluent_time_methods_it_should_return_the_correct_time_span_value()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            TimeSpan time1 = 23.Hours().And(59.Minutes());
            TimeSpan time2 = 23.Hours(59.Minutes()).And(20.Seconds());
            TimeSpan time3 = 1.Days(2.Hours(33.Minutes(44.Seconds()))).And(99.Milliseconds());

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new TimeSpan(23, 59, 0), time1);
            Assert.AreEqual(new TimeSpan(23, 59, 20), time2);
            Assert.AreEqual(new TimeSpan(1, 2, 33, 44, 99), time3);
        }

        [TestMethod]
        public void When_specifying_a_time_before_another_time_it_should_return_the_correct_time()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            DateTime now = 21.September(2011).At(07, 35);

            DateTime twoHoursAgo = 2.Hours().Before(now);

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new DateTime(2011, 9, 21, 05, 35, 00), twoHoursAgo);
        }

        [TestMethod]
        public void When_specifying_a_time_after_another_time_it_should_return_the_correct_time()
        {
            //-----------------------------------------------------------------------------------------------------------
            // Act
            //-----------------------------------------------------------------------------------------------------------
            DateTime now = 21.September(2011).At(07, 35);

            DateTime twoHoursLater = 2.Hours().After(now);

            //-----------------------------------------------------------------------------------------------------------
            // Assert
            //-----------------------------------------------------------------------------------------------------------
            Assert.AreEqual(new DateTime(2011, 9, 21, 09, 35, 00), twoHoursLater);
        }
    }
}

redpajama_set_name: RedPajamaGithub


Throughout history there have been many figures and movements deserving of mockery, yet they somehow escaped unscathed, comedian Matt Strickland aims to rectify that situation. No historical figure will be safe as everyone from Rasputin to The Beat Generation to The 1968 Democratic Convention will become targets of New York's best and meanest comedians.
REFUND POLICY: Tickets may be refunded up to 24 hours before the event. Within 24 hours we may take exchanges for other events at our discretion. No refunds after the event.


How an airplane transmits its "feel"
You're driving down the road when the traffic light ahead turns yellow. Unlike those high insurance risks driving the cars around you, you decide to slow down for the ensuing red light and press on the brake pedal hard enough to achieve the desired deceleration.
Now imagine that it doesn't take any force to depress the brake pedal. It moves as soon as your foot touches the pedal. The farther you move your foot, the farther the pedal moves, but you can't feel it. If you withdraw your foot, the pedal comes back as well, but you still feel no force on the bottom of your foot. The car's reaction is your only cue to how much brake you're applying.
Think this might take some getting used to? Think you'd ever like it? What about a panic stop? Think there might be any tendency to over-brake?
Every time we physically interact with someone or something we rely on tactile feedback. More than a sense of touch, we use tactile feedback to know how hard to push, how tightly to squeeze, what feels good, and what hurts. You use this feedback mechanism, or cue, every time you fly.
Most general aviation airplanes have "reversible" flight controls, which means you have a direct physical connection - push-pull tubes, cables, torque tubes, etc. - between the cockpit controls and the control surfaces. Therefore, the pilot feels the air load on a deflected control surface. Actually, the amount of force feedback the pilot feels depends on mechanical engineering factors - the hinge moment of the deflected control and the gearing of the linkage, but the important point is the pilot feels a force proportional to the air load on the control surface.
Generally, the larger the cockpit control displacement, the larger the control surface deflection, and the higher the force needed on the stick, or yoke, and pedals. That works out nicely because the farther the pilot flies from the airplane's trimmed condition, the stronger the control-force feedback should be. Let's say you're trimmed for 100 knots in straight and level flight. You expect to hold back-yoke to fly at 80 knots, assuming you don't re-trim or adjust the throttle. You also expect to hold more back-yoke at 70 knots than at 80 knots.
Holding back-yoke lets you know that you're flying off-trim. The increasing control force requirement for progressively slower airspeeds gives you an idea of how far off-trim you're flying. Wait a minute - that's the airspeed indicator's job. Yes, and the control-force feedback is another source of information you can use to corroborate or suspect the indicator's reading. It's just like pitch attitude and wind noise and engine-propeller noise and probably a half-dozen other cues so subtle we don't realize we use them.
Initially, this example of yoke force as a cue to an airspeed change might sound a little far-fetched. Then again, pitot-static systems have been known to become blocked by ice, and pilots have been known to focus on VASI lights or the glideslope and localizer needles and let the airspeed indicator fall outside their scan. Having these inadvertent airspeed deviations channeled through the yoke is a nice back-up, but you have to be aware of this channel and what this force information is telling you.
Control-force feedback has other advantages. Once you get the "feel" of an airplane you can make better initial control displacements. Because you know how much force it takes, you can apply that force without the experimentation you had to go through the first time you flew the plane. You know how much yoke pull it takes to rotate for takeoff, flare for landing, compensate for lowering the flaps, etc. This predictability allows you to make those smooth transitions you're known for to everyone at the FBO.
Cockpit control-force feedback is not limited to airspeed changes. You may have heard of "stick force per G," an expression associated with maneuvering flight. Although this specific longitudinal stability term is often misused, the basic force-feedback idea generally comes through. The issue is how hard you have to pull to pitch the airplane to the attitude you want.
All three control axes are fair game for control feedback. Rolling out on a heading following a turn, you stop the roll when the wings are level. There's no disputing that the real or artificial horizon is your primary cue for achieving the wings-level goal. But the disappearance of lateral yoke force is another significant information channel that tells you where to place the yoke when you want no more roll rate. To begin the rollout you turn the yoke, and as you approach wings-level you turn the yoke toward its pre-roll position. Have you ever actually looked at the yoke during this task? Probably not, but you rely on the reduction of force you must apply to tell you when the yoke is back at the neutral position - force feedback.
How much force is the right amount depends on several factors. Should airliners have higher cockpit control forces than general aviation airplanes? What about the Airbus A-320, which uses a side-stick instead of the traditional yoke? Should the touch of the control stick in an aerobatic airplane be different from that of a similar airplane not designed for aerobatics? Should a trainer feel different from a business jet?
Generally, you can expect higher cockpit control forces in larger airplanes. This isn't because their larger control surfaces require more force to deflect. A better explanation for designing these higher cockpit control forces is solidly rooted in the whole feedback idea. Higher forces are there to continuously remind the pilot to be smooth and deliberate when flying this airplane. The hundred or so passengers on board want to peck at their laptops, watch the movie, or savor the in-flight cuisine, and blistering roll rates and two-G turns seem to extract some of the enjoyment from these activities. Designing the stick force per G on an airliner to be around 50 lb/g helps ensure non-aggressive normal maneuvering while preserving the pilot's ability to perform emergency maneuvers when necessary.
Let's take our cockpit control force example in the other direction. It's possible to design a reversible control system that requires very little force to deflect the control surfaces. That can translate into tiny cockpit control forces needed for flying far off-trim, or for pulling a lot of G or for achieving a very fast roll rate. We might classify these control systems as sensitive.
Of course, airplanes designed to produce high-G, dizzying roll rate maneuvers should not have the same cockpit control-force feedback as an airliner. These specialty aerobatic machines still must provide feedback to their pilots, but the forces should not be so high that the pilot is exhausted after just a few minutes of maneuvering. Keep in mind also that these airplanes are usually flown by experienced and accomplished pilots who may be more attuned to subtle cues than the rest of us.
Cockpit control-force feedback varies widely among the hundreds of homebuilt airplane designs on the market. They range from two-hands-required-for-a-full-stick-roll to a single finger stick pull for a three-G pitch-up. You won't see this variety among modern general aviation airplanes because the certification regulations specify some cockpit control-force requirements. Another reason is that the manufacturer wants to produce an airplane that "feels" like it should be flown a certain way. You should not be flying loops in a Cessna 172, which is, perhaps, one reason why the 172's stick force per G is more than 20 lb/G. Usually, pilots start a loop with at least a three G pull, which means the yoke force for a 172 (40 pounds) would be discouraging.
The type and location of cockpit controls are other things that vary in homebuilt aircraft. Side-sticks are popular, particularly in small or narrow cockpits. These control sticks are short - usually less than 12 inches from the top of the grip to the pivot point. That means they have a lot less mechanical advantage than a conventional center stick, which has its pivot on or beneath the cockpit floor.
By design, a side-stick is for one-hand use. So is a center stick, but at least the pilot has the option of grabbing the stick with his other hand. Naturally the stick force requirements for a low-mechanical-advantage, one-hand, limited-displacement side-stick should be different from the yoke of the four-place, single-engine, general aviation airplane. Yoke forces are usually higher than stick forces. The reasoning here is the two- versus one-hand operation.
Relative size matters, too. How much force it takes to pull, push, and move the stick left and right, and how these forces compare to each other, also affects the airplane's handling qualities. Imagine flying an airplane that requires a 25-pound pull to flare to land. That's about the weight of three one-gallon jugs of water - a pretty hefty tug. Next, imagine it only takes a few ounces of force to begin rolling the airplane. Do you think it might be difficult to keep the wings level during the flare?
Control harmony is the compatibility between cockpit control forces in the different axes. It can be quite challenging to modulate ounces of yoke force in roll while applying dozens of pounds of yoke force in pitch, particularly if a gust of wind hits you from the side.
The generally accepted ratio of reasonable control forces among roll, pitch, and yaw is 1:2:4. Pitch control force should be about twice the roll control force, and pedal force should be twice the pitch force and four times the roll force. This relationship makes sense. Our leg muscles are huge compared with our arm muscles. Any effort exerted by a pilot's legs should be heavier. We are also stronger pulling toward and pushing away from our chest than we are exerting an extended arm effort side to side. Most pilots are happy with the 1:2:4 ratio, which has been around for about 50 years now.
When the original airplane design doesn't have the desired cockpit control-force feedback, designers resort to gadgets. You've seen them. Aileron spades, servo tabs, and aerodynamic balance horns are a few of these force-altering devices attached to various control surfaces. These fixtures all reduce the amount of force you must exert on the cockpit control. They all provide a hinge moment opposite to the hinge moment caused by the air on the deflected surface. What you feel in the cockpit is the difference between these two moments, and it is less than it would be without the device installed.
Not all force-altering devices are designed to reduce the cockpit control force. Some are intended to increase the feeling. Using an anti-servo tab is a common way to increase the cockpit control force. This trailing edge tab deflects in the same direction as the surface it's attached to. It sticks farther into the air flow, which means you must apply more muscle to deflect the surface.
Some force-shapers are internal. Springs are commonly used in airplane control systems. These can be helping or opposing springs whose function is to decrease or increase the cockpit control force, respectively.
A bob weight is another internal force-maker that is used in the longitudinal, or elevator, control system. The bob weight adds or subtracts stick/yoke force based on its location in the control system and the airplane's pitch rate and acceleration. Because the bob weight has mass, it has inertia that opposes any change to its motion.
Picture a mass attached to the end of a rod that extends forward from the control stick. When the pilot pulls the stick back the airplane pitches nose-up. As the airplane pitches nose-up the bob weight pulls downward - trying to pull the stick forward - because of its inertia. The pilot has to pull harder on the stick to overcome this forward pull of the bob weight in addition to the normal pull force associated with the deflected elevator.
If the bob weight were on a rod that extended aft from the control stick, it would tend to lighten the pull force needed. Bob weights are usually incorporated somewhere along the longitudinal control system other than the control stick, but the effect is the same.
For all the stick force per G, hard maneuvering, and full-stick rolls we talk about, most of us spend most of our flying time in one-G flight. Whether we're climbing, cruising, or descending, we're always trimming the airplane for hands- and feet-free flight. Whenever we change the flight condition, we move the stick/yoke and pedals first. The minimum cockpit control force necessary to make the airplane pitch, roll, or yaw is called "breakout."
To see how breakout might affect your flying, imagine a flight control with no breakout in the pitch axis. The tiniest force exerted on the yoke causes the airplane to pitch. Even keeping a hand on the yoke is likely to cause inadvertent control inputs, and each of these inputs results in an unwanted airplane response.
Now let's crank up our imaginary breakout to six pounds, or the weight of a six-pack of 16-ounce soft drinks in plastic bottles. No inadvertent inputs here. Anything short of a substantial and intentional effort won't change the airplane's attitude.
Think you might have some difficulty with precision in this scenario? Too much breakout makes it hard to fine tune a control input. Depending on the control forces after the breakout, you might be pulling or pushing way too hard.
For example, suppose it takes six pounds to start the airplane pitching nose-up, but only seven pounds to generate a two-G pitch-up. Chances are good you'd be in for a less than comfortable flight. Fortunately most airplanes are not this extreme.
The right amount of breakout is enough to preclude unintended control inputs, but not so much as to make small control inputs difficult. Like the harmony between pitch and roll control forces, the relationship between breakout and control forces beyond the breakout must be compatible. Too much of one and not enough of the other makes for predictability problems and sabotages your efforts to be smooth.
Friction is everywhere, including flight control systems. Friction is the force that opposes the motion of one object relative to another. Bearings, cables in pulley channels, and hinges are a few of the flight control components where friction occurs. Most things are fine in moderation, but friction in a flight control system is not. Generally, we pilots like as little friction as possible.
Too much friction can prevent a displaced flight control from returning to its pre-displaced position. If this happens, the airplane is no longer in trim, and you're deprived of the force cue that tells you the control is in the wrong place. Re-trimming the airplane is one way to deal with this, but all you'd be doing is trimming through the friction band. You can reposition by trial and error until you happen upon the correct position. Either way the friction wins. You'll be distracted, off-trim, and probably frustrated.
Time for another imaginary airplane. This one has a generous amount of friction in the roll control system. The breakout is extremely low, and aileron spades compensate almost completely for the air loads. Got it? You've just rolled out on final approach. You return the yoke to where you think it was on base leg before the turn to final, but the airplane still rolls. You turn the yoke slightly to arrest the roll rate, and now it is rolling slowly the other direction. Again you adjust the yoke position, and again a persistent residual roll rate remains.
You have no force feedback, because the friction allows you to leave the yoke anywhere within a range of positions, and only one place within that range is the correct zero-roll-rate position. Your only recourse is trial and error. Had there been less friction and a more definitive force required when you displaced the yoke, you might have been able to converge on that correct position more expeditiously by simply returning the yoke to the zero-force position.
We pilots use all sorts of feedback channels every time we fly. All senses are working all the time even when we're not consciously feeling, listening, or looking. We can't ignore the big ones - the fumes in the cockpit or the sudden change in engine noise. But we might miss the more subtle ones if we're not prepared to observe them. Cockpit control forces fall into both categories. You're already aware of the high forces - now start feeling for the subtle ones.


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« How to "Reset" Your Life.
Today we ask that you stop overthinking.
Overthinking is a major energetic block for most people.
Humans aren't born overthinking. It's a learned process. A bad habit, really. It's a good thing that humans aren't born overthinking. If babies and toddlers thought too much, they'd never learn to walk or talk or do much of anything.
Children are taught to overthink, by overthinking adults. It's like a neurological computer virus that spreads from mind to mind, and makes the human consciousness quite buggy and inefficient. Like a slow computer.
Overthinking means you are continually at war with a Voice in your head.
You wish to do something. The Voice gives you reasons why you shouldn't do that thing. Usually fear-based reasons. You become paralyzed, tentative, uncertain.
Imagine if a robot were programmed to overthink every decision.
If you commanded the robot to, let's say, pick an object up off the floor, a simultaneous counterprogram would tell the robot not to pick the object off up the floor.
The poor robot would be paralyzed. Steam would come out of its ears.
This is the state many humans find themselves in. They want to do something, but at the same time they do not want to do something.
As soon as they contemplate an action, a fear-based countering Voice tells them all the reasons why they should not take this action. In order to do anything, they must first argue with, and defeat, the countering Voice. A huge amount of energy is wasted in this process.
Notice how often you overthink. How often you contemplate taking an action, then meet with a countering Voice of fear and resistance.
This Voice likes to say that it is your friend, and is only trying to keep you safe. But in reality, it is not helping you at all. It is just wasting your time and energy.
It is only keeping you blocked, stuck, depleted, and paralyzed.
This is generally a process of unlearning. You must return to a state of playful openness and curiosity that is much more child-like. This is why children are capable of learning and advancing so rapidly. They have not yet learned to be paralyzed by fear and self-doubt.
The first step in this process is just to notice how often you experience paralysis and indecision when it comes time to take an action. How much mental arguing goes on?
On a scale of 1 to 10, how much would you say you overthink?
Please do not judge yourself, if you are an "overthinker." It is a learned habit. Most likely you have been around parents, teachers, or other influential figures who have taught you that it is prudent, sensible and responsible to overthink everything.
Just make a commitment to think less.
This may sound counterintuitive, or even foolish. But truly, if you wish for greater happiness and fulfillment in your life, you must think less.
If you think less, you will do more.
All athletes understand this truth. Too much thinking is an impediment to smooth and flowing action.
Think less, and you will do more.