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Home Lifestyle A GREAT NIGHT TO SERVE UP SMILES ACROSS THE COUNTRY
A GREAT NIGHT TO SERVE UP SMILES ACROSS THE COUNTRY
Last week, Justin Hartley, NBC This Is Us, took over the web and hosted the enCourage Kids Serving Up Smiles virtual event presented by Revel Spirits. Michele Hall Duncan, President & CEO enCourage Kids Foundation along with Ryan Field, ABC Sports Anchor, who emceed the event, was live at Ben & Jack's Steakhouse in NYC. Super star guests joining them were NY Giants Super Bowl Champions Howard Cross and Luke Petitgout and former NY Jets star Tony Richardson who are dedicated supporters of the organization.
Culinary Chair, Ralph Scamardella (Chef & Partner TAO Group) along with Chef John Cleveland (Executive Chef & Owner Post & Beam LA) and Chef Jessica Scott (Corporate Pastry Chef 50 Eggs Hospitality Group) showed off their culinary skills by demoing their favorite dishes live from their own homes. Demonstrating their mixology talents, were Jimmy Seargeant (Creative Director Revel Spirits), Tony Margiotta (President Gladiator Wine Distribution) and Roger Mulligan (Beer Aficionada The Capital Grille).
I caught up with Duncan to speak to her about their first virtual event. "Producing a virtual event was a completely new experience for us and it was exciting to be able to connect with people from across the country who likely would not have attended our in-person event." I certainly agree with Duncan because lately, we have been able to attend virtual events as far as Europe which is such a big upside for guests living far away. "Yes, for sure! Our guests had the opportunity to hop-in and out of the session rooms to enjoy musical guest Acute Inflections, Matias Letelier (Illusionist) and Katrina "Kat Tat" Jackson (Commercial & Tattoo Artist). Guests were able to see world-class chefs in the Kitchen and mixologists in the Bar."
The evening also honored some very important people. "Yes! We recognized Cory Elbaum who is with Angelo Gordon and Rob Turner who is with Eastdil Secured, LLC with the Jeffrey Gural Leadership Award and Dr. Kusum Viswanathan who is the Chair of the Department of Pediatrics at Brookdale Hospital Medical Center in Brooklyn and the hospital's Director of Pediatric Hematology & Oncology with the Healthcare Leadership Award. She is one of the most highly regarded physicians in her field, beloved by other medical professionals, patients and parents alike. Her expertise has made her a vital partner to enCourage Kids for over 20 years. Leading with passion and empathy, ensuring every child feels heard and understood, Dr. Vis is the living embodiment of our values as an organization and it was a distinct pleasure to honor her." Dr. Vis certainly deserves the recognition for her dedication and I congratulate her as well.
The night was certainly a success and there were so many generous sponsors and guests involved in the success of the night. "I'm beyond grateful for the support from Revel Spirits, GFP Real Estate, Signature Bank, Humana, Feil Family Foundation, DJ Chef and all those who attended the event. Also, my staff at enCourage Kids, Indra Public Relations and Marc Brogdon all did an amazing job in ensuring the success of this event and I thank them all from the bottom of my heart." It is always nice to recognize the hard work of those who work for you. How will you look at the events going forward? "We will continue to look for new opportunities to engage our donors in an increasingly competitive landscape. What our fundraising events look like will, of course, depend on the track the pandemic continues to take. The introduction of a COVID-19 vaccine is very encouraging and we are hopeful to be able to hold an in-person Annual Gala in the spring. But like most non-profits, we are also exploring other options in the virtual space." I think we are all starting to see that light at the end of the tunnel now that the vaccine will be distributed throughout our country. Honestly, I miss the in-person events and attending all of yours. They are always fun, well-attended and exciting to be at. "Thank you!"
Next up, our favorite time of the year, the holidays. What will enCourage Kids be doing this year for the families? "Every year we plan a large holiday party for more than 100 of our enCourage Kids and their families which takes place at the amazing Clyde Frazier's Wine & Dine Restaurant. Since we weren't able to hold an in-person party this year, we will be going virtual! We have a fun schedule of activities planned to include arts & crafts, holiday games, live entertainment, a raffle with amazing prizes, and the children will even have the opportunity to meet Santa in a separate virtual room. Throughout the pandemic, we have organized several virtual gatherings and are so grateful to be able to provide a fun and supportive space for our enCourage Kids families to connect with us and each other from the safety of their homes. The feedback from the families has been incredible." That's fantastic and a great pivot during these times. That certainly sounds like great fun for the children and their families in the comfort and safety of their homes.
You have provided support to over 286 hospitals. Will you continue to add to your long list? "Absolutely! We believe in our vision of a world where every child—regardless of the difficulty of their medical journey—experiences joy, hope, resilience, and healing. Over the past several years, we have grown from a tri-state area organization to one that partners with 286 pediatric facilities in 41 states and Puerto Rico, and we want to reach even more!" That is fantastic and I commend you for your outstanding work and resilience. Looking ahead to 2021, what do you see for the organization? Ever since the pandemic hit, our focus has been to step in and help the communities that are inundated, providing the support and critical resources they uniquely need, when they need it. For years, we have listened to the needs of Child Life Specialists across the country. We hear them now when they say things around them are changing at a rapid pace. What they need today may look completely different than what they need tomorrow or from what they needed two months ago. They are trained to be flexible, adaptable, and creative. So are we. For months, we have been working closely with hospitals across the country to respond to immediate needs and preemptively prepare for what is to come and we will continue to do more of that in 2021.
The pandemic has taught us a lot; in particular it has taught us to be flexible and to think outside the box. As a result, we are planning an innovative new program initiative to launch in Spring 2021 that will change the delivery of our in-hospital programming as well as increase our reach and impact across the country. We're really excited about it and encourage everyone to stay tuned and follow us on our social media to learn more in the coming months." Wow! I commend you on your tireless efforts and the wherewithal to shift gears in order to help those children and families as well as the Child Life Supporters who need as much assistance as possible during challenging times. "Thank you so much! I feel blessed to do what I love each and every day knowing that we can make a difference in so many lives."
"I truly appreciate this opportunity to let readers know about the amazing work we do. We try to help everyone in the hospital who is on the frontline — the Child Life Specialists, the doctors, the nurses — with the things that they need that insurance doesn't cover, to help those hospitalized children and their psychosocial well-being. We have been doing this for 35 years and we are a true leader and an impactful partner with hospitals across the country. Over the years, we've invested over 50 million dollars to help medically challenged kids, their families, and hospitals, and we're excited to do even more. It's our passion for improving the lives of these kids and their family members that continues to drive us, especially now. Through all the challenges we are facing today, children still need our support more than ever. Hospitals need our support more than ever. Communities need our support more than ever. This means that we need donor support more than ever. We are grateful to all the generous supporters who help us keep our promise to humanize healthcare for children and their families."
I can't thank you enough for taking the time to speak with me and sharing the great work that you're doing! I wish you continued success and I look forward to seeing you at the next event hopefully, in-person. "Thank you so much for speaking with me and I look forward to seeing you soon! I wish everybody a blessed holiday season."
To learn more about the organization and make a donation: www.encourage-kids.org.
You can be social with the enCourage kids everyday all day and share their great work you're your community!
https://www.facebook.com/search/top/?q=encourage%20kids, https://www.instagram.com/encouragekids/
https://twitter.com/encourage_kids
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Delaware correctional officer pension boost proposed
Matthew Albright
Clarification: This article has been updated to more accurately describe the actions taken by the Senate Finance Committee.
The unions that represent state employees who work in Delaware's prisons are pushing hard for a bill that would allow correctional officers and other "peace officers" to retire with 20 years of service instead of 25.
The groups say the change would help end chronic staffing shortages in Delaware's prisons, which they argue are the root cause of the Feb. 1 inmate takeover at James T. Vaughn Correctional Center near Smyrna that left Lt. Steven Floyd dead.
IN-DEPTH: An inside look at what happened at Vaughn
But they must convince legislators — who already are struggling with a $386 million budget gap — to grant them significantly higher compensation at a time when raises for other state employees have been sparse.
"The longer we continue to do nothing, the closer we get to making history in Delaware, and not in a good way," said Geoffrey Klopp, head of the Correctional Officers Association of Delaware, warning "another riot" could be on the horizon. "This must be done. This must be done as soon as possible. The gravity of this situation is heavier than my words can express."
The base salary for Delaware correctional officers is about $32,060, compared with $40,000 in New Jersey and $38,258 in Maryland.
The Senate Finance Committee on Wednesday considered, but did not vote on legislation that would begin to increase compensation for correctional officers and other "peace officers" by making pensions more generous.
The proposal would not just apply to correctional officers. It would also cover other "peace officers," like the Capitol Police, University of Delaware Police and court constables.
The bill would lower the number of years of service an officer must rack up before retiring, from 25 to 20. That would put them in line with other law enforcement officers in Delaware, like the state police.
"What this bill is trying to do and what this bill needs to do is create parity for all law enforcement in the state of Delaware," said Todd Mumford, president of the Fraternal Order of Police Lodge 10, which represents probation and parole officers.
Last year, the General Assembly reduced the requirement from 30 years to 25.
THE TURNOVER PROBLEM: Officers quitting since the Vaughn crisis
The legislation would also increase the "multiplier" used to calculate the amount of pension payments.
The officer would earn 2.5 percent of his or her final salary, which would be multiplied by the number of years served, up to 20 years. Years served after 20 years would be multiplied by 3.5 percent.
Currently, the rate is 1.85 percent, 2 percent or 2.45 percent, depending on the type of officer.
All told, the more generous pensions would cost the state about $6.1 million a year, according to estimates from the state Controller General's Office.
Sen. Bruce Ennis, whose Smyrna district includes Vaughn and who sponsored the pension bill, argued the measure might save money in the long run if it helps slash overtime costs. He said the state paid $23 million in overtime for the Department of Correction last year.
"$23 million could go a long way toward the cost of this bill," Ennis said.
Klopp said the pension increases are only part of the compensation package his association wants. His group also seeks "step increases" that would automatically increase officers' pay as they contribute more years of service.
"This is one of the puzzle pieces to making the compensation the appropriate compensation package," Klopp said of the pension bill.
The pay increase proposals are designed to reward employees for staying on staff for years. The goal is to cut down on turnover.
While few legislators are publicly against raising pay for correctional officers, it will be hard for them to find a way for them to pay for it. The state is facing a $386 million budget hole — Gov. John Carney announced a plan last week to hike taxes and slash spending throughout state government.
DETAILS: Learn more about Gov. Carney's budget.
Carney's budget included increasing hazard duty pay for correctional officers to the tune of $4.7 million. On top of a 1.5 percent pay hike, COs are slated to get through collective bargaining, the governor's administration says pay would effectively jump to $37,120.
Carney also has called for buying new equipment and adding more officers to both Vaughn and Baylor Women's Correctional Institution.
When Carney's budget was revealed, Klopp said it was an insufficient increase, calling it a "slap in the face" to his membership. He said his group is seeking a salary of around $48,000.
Carney attended a correctional officers' town hall on Tuesday night that was closed to the press.
If the General Assembly were to approve either the pension plan or more generous salary increases, legislators would need to find millions of dollars more in either new taxes or further program cuts in state government.
Contact Matthew Albright at malbright@delawareonline.com, (302) 324-2428 or on Twitter @TNJ_malbright.

redpajama_set_name: RedPajamaCommonCrawl


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If I could not go to Heaven but with a Party, I would not go there at all.
—Jefferson, in a Letter to Madison
William and Mary College was founded in Sixteen Hundred Ninety-two by the persons whose names it bears. The founders bestowed on it an endowment that would have been generous had there not been attached to it sundry strings in way of conditions.
The intent was to make Indians Episcopalians, and white students clergymen; and the assumption being that between the whites and the aborigines there was little difference, the curriculum was an ecclesiastic medley.
All the teachers were appointed by the Bishop of London, and the places were usually given to clergymen who were not needed in England.
To this college, in Seventeen Hundred Sixty, came Thomas Jefferson, a tall, red-haired youth, aged seventeen. He had a sharp nose and a sharp chin; and a youth having these has a sharp intellect–mark it well.
This boy had not been "sent" to college. He came of his own accord from his home at Shadwell, five days' horseback journey through the woods. His father was dead, and his mother, a rare gentle soul, was an invalid.
Death is not a calamity "per se," nor is physical weakness necessarily a curse, for out of these seeming unkind conditions Nature often distils her finest products. The dying injunction of a father may impress itself upon a son as no example of right living ever can, and the physical disability of a mother may be the means that work for excellence and strength. The last-expressed wish of Peter Jefferson was that his son should be well educated, and attain to a degree of useful manliness that the father had never reached. And into the keeping of this fourteen-year-old youth the dying man, with the last flicker of his intellect, gave the mother, sisters and baby brother.
We often hear of persons who became aged in a single night, their hair turning from dark to white; but I have seen death thrust responsibility upon a lad and make of him a man between the rising of the sun and its setting. When we talk of "right environment" and the "proper conditions" that should surround growing youth, we fan the air with words–there is no such thing as a universal right environment.
An appreciative chapter might here be inserted concerning those beings who move about only in rolling chairs, who never see the winter landscape but through windows, and who exert their gentle sway from an invalid's couch, to which the entire household or neighborhood come to confession or to counsel. And yet I have small sympathy for the people who professionally enjoy poor health, and no man more than I reverences the Greek passion for physical perfection. But a close study of Jefferson's early life reveals the truth that the death of his father and the physical weakness of his mother and sisters were factors that developed in him a gentle sense of chivalry, a silken strength of will, and a habit of independent thought and action that served him in good stead throughout a long life.
Williamsburg was then the capital of Virginia. It contained only about a thousand inhabitants, but when the Legislature was in session it was very gay.
At one end of a wide avenue was the Capitol, and at the other the Governor's "palace"; and when the city of Washington was laid out, Williamsburg served as a model. On Saturdays, there were horse-races on the "Avenue"; everybody gambled; cockfights and dogfights were regarded as manly diversions; there was much carousing at taverns; and often at private houses there were all-night dances where the rising sun found everybody but the servants plain drunk.
At the college, both teachers and scholars were obliged to subscribe to the Thirty-nine Articles and to recite the Catechism. The atmosphere was charged with theology.


Sorry, forgive the pun. Piano, Roxy, music…… But actually, photographing professional glamour model Roxy Mendez was music to my ears. Roxy was an absolute joy to work with. A total professional who knows how to work the camera. I'd photograph her again anytime.
The photoshoot was held at a fantastic location. A huge house complete with grand drawing room and piano. I just had to use it.
The lighting for this set was pretty simple. I used two Elinchrom studio flash units. The main light from the front was fitted with a large softbox. A back light was fitted with a bare reflector dish and barn-doors and used to add some hair and rim lighting onto Roxy.
My photography blog is four years old!
By the way, today is my website's fourth birthday. I published my first blog post on 19th November 2012 and have published updates every month since. I'm actually quite proud of the fact that I've kept the site going all this time. So many blogs launch with good intentions then fizzle out through lack of content. Running a blog takes time. You need to be quite disciplined to force yourself to sit down and update the site regularly.
Over the last four years I've received dozens of emails from photographers from all over the world, asking for advice or commenting on certain photographs or blog posts. Every email receives an answer and I'm always happy to help where I can.
In this time I've also photographed scores of people – professional glamour models, amateur models and first-time models, both female and male. I'm currently trying to play catchup with a backlog of images waiting to be post-processed and published. I hope to be bringing you more images for many years to come. Do please feel free to comment and tell me what you would like to see on this site.
As ever, thank you for reading. Click on each image to see it bigger and please feel free to leave a comment below.
Congratulations on reaching your fourth anniversary! It's been great to see what you've achieved.
Just came upon your site ( a link via dpreview forum) and just what I needed, and when. Still consider myself an amatuer photographer (even after 113 wedding shoots) due in part to being self taught off the internet. I have had every intention of getting into more boudoir but lacked focus. Your photography, posted photos and direction (lighting scenarios) is giving me encouragement. I have all the gear just needed encouragement (push). Will read all I can on here and practice, practice. My website now down as I have stopped Wedding photography.Perhaps I can share photos in the future for critique.Love your work.
Thank you so much for taking the time to leave a comment. I'm flattered by your words and that my website has inspired you.


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Verilog Code For 8 Bit Parallel In Serial Out Shift 31 Fix
HomeInterior DesignVerilog Code For 8 Bit Parallel In Serial Out Shift 31 Fix
Download ✅ DOWNLOAD (Mirror #1)
Verilog Code For 8 Bit Parallel In Serial Out Shift 31
verilog code 8 bit parallel in serial out shift 31 I'm trying to do very basic code in C in 8 bit machine mode.
I have successfully used this on my old laptop and now I am trying on a new one.
My new machine has a 32-bit processor (with a 128-bit address and a 32-bit x86, and actually a 32-bit processor on an x86-compatible environment that uses C in 16-bit mode.)
My goal is to use 8 bit 32 bit C mode, but I haven't been able to get my code working properly.
I'm using .
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This approach is particularly useful in the design of complex circuit-based hardware .
Definition of D-LFSR. Design a circuit to generate pseudo-random numbers of D-length with maximal period P using D-LFSR. Demonstrate that D-LFSR is a class of linear recurrent. 32-bit linear-feedback shift registers can be seen as a dynamic shift register.. 31. How to design a forward binary 2-tap linear-feedback shift register? A) circuit and B) VHDL code.
What is the difference of the simulation results of the 3 codes?Gaze direction does not affect visual distraction within manual load carriage.
The aim of this study was to determine whether gazing in a different direction would affect the number of errors or time spent in concentration during visual search of a task area of interest while wearing heavy military uniform and vest without load. Twenty male military recruits performed visual search tests while weight was added stepwise to their lower back (0-50% of body weight). A total of 50 errors was recorded, the search task was repeated four times within each of five different viewing directions (right-left, front-back, up-down, left-right, and up-down) at each level of load. The search task was performed with load under two modes of constraint: one in which the task area of interest was defined as the task aperture, and one in which the task area of interest was defined as a specific object. The results did not show a difference in number of errors or percentage of time spent concentrating in any of the directions or load conditions, and the results did not differ with whether the task area of interest was defined as the task aperture or a specific object. We propose that the eye-head-lens triangle should not be altered to enable gazes in different directions to be assessed in future experiments.Rakavi
Rakavi (d. after 942) was a Bulgarian military leader.
Rakavi is first mentioned as a member of a military unit sent by Emperor Samuil in 924-925.
In 927 he was a member of the court of Tsar Samuil, because of his military activities.
As a reward, he was appointed as a governor of the Sviatoslav, Drobnitsa and other provinces on the southern border of Bulgaria. He led an army to settle the Serdi Monastery. Rakavi ruled these lands until his
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We have recently updated our ISBE module to include some key enhancements not found in any other software, including.
The outline, found at the beginning of many larger entries, is linked to the corresponding section in the body text. A click will take you there! Nearly 12,000 links!
When the cursor is placed over another topic link, a preview will display the beginning of that topic. A click will take you there.
This allows the instant display of all places in the title that includes the current Bible verse selected in the Bible panel.
We have made several formatting changes to improve text display, such as making section headings bold, making outlines have bold digits and indentation, etc.
These new features along with Bible Analyzer's other study features makes this module of the International Standard Bible Encyclopedia one of the most useful available.
Developed by a team of over 200 of the world's most renowned Bible scholars, under the direction of Dr. James Orr, International Standard Bible Encyclopedia (ISBE) is a classic six-volume work that explains practically every word in the Bible.
This exhaustive reference features over 9,300 articles with definitive background information about the people of the Bible, Greek and Hebrew word meanings, archeology, history, customs, daily life, and much more. It is an asset to any believers study library.
This resource is considered by many as "strongly conservative."


text:
Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor
Bernadette V. Marquez, Oluwatayo F. Ikotun, Jesse J. Parry, Buck E. Rogers, Claude F. Meares, Suzanne E. Lapi
Imaging agents based on peptide probes have desirable pharmacokinetic properties provided that they have high affinities for their target in vivo. An approach to improve a peptide ligand's affinity for its target is to make this interaction covalent and irreversible. For this purpose, we evaluated a 64Cu-labeled affinity peptide tag, 64Cu- L19K-(5-fluoro-2,4-dinitrobenzene) (64Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF) as a PET imaging agent. We compared the in vivo properties of 64Cu-L19K- FDNB in VEGF-expressing tumor xenografts with its noncovalent binding analogs, 64Cu-L19K-(2,4-dinitrophenyl) (64Cu-L19K-DNP) and 64Cu-L19K. Methods: The L19K peptide (GGNECDIARMWEWECFERK-CONH 2) was constructed with 1,4,7-triazacyclononane-1,4,7-triacetic acid at the N terminus for radiolabeling with 64Cu with a polyethylene glycol spacer between peptide and chelate. 1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB. 64Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro. As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP. PET imaging and biodistribution studies of 64Cu-L19K-FDNB, 64Cu-L19K-DNP, and the native 64Cu-L19K were compared in HCT-116 xenografts. Blocking studies of 64Cu-L19K-FDNB was performed with a coinjection of excess unlabeled L19K-FDNB. Results: In vitro binding studies confirmed the covalent and irreversible binding of 64Cu-L19K-FDNB to VEGF, whereas 64Cu-L19K-DNP and 64Cu-L19K did not bind covalently. PET imaging showed higher tumor uptake with 64Cu-L19K-FDNB than with 64Cu-L19K-DNP and 64Cu-L19K, with mean standardized uptake values of 0.62 ± 0.05, 0.18 ± 0.06, and 0.34 ± 0.14, respectively, at 24 h after injection (P < 0.05), and 0.53 ± 0.05, 0.32 ± 0.14, and 0.30 ± 0.09, respectively, at 48 h after injection (P < 0.05). Blocking studies with 64Cu-L19K-FDNB in the presence of excess unlabeled peptide showed a 53% reduction in tumor uptake at 48 h after injection. Conclusion: In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tracer accumulation at the tumor site in vivo, compared with its noncovalent binding peptide analogs. This technique is a promising tool to enhance the potency of peptide probes as imaging agents.
https://doi.org/10.2967/jnumed.113.130898
Covalent
Molecular imaging
10.2967/jnumed.113.130898
Dive into the research topics of 'Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor'. Together they form a unique fingerprint.
2,4-dinitrobenzene Medicine & Life Sciences 100%
Vascular Endothelial Growth Factor A Medicine & Life Sciences 62%
Peptides Medicine & Life Sciences 46%
1,5-difluoro-2,4-dinitrobenzene Medicine & Life Sciences 17%
1,4,7-triazacyclononane Medicine & Life Sciences 15%
Heterografts Medicine & Life Sciences 14%
Injections Medicine & Life Sciences 13%
Marquez, B. V., Ikotun, O. F., Parry, J. J., Rogers, B. E., Meares, C. F., & Lapi, S. E. (2014). Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor. Journal of Nuclear Medicine, 55(6), 1029-1034. https://doi.org/10.2967/jnumed.113.130898
Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor. / Marquez, Bernadette V.; Ikotun, Oluwatayo F.; Parry, Jesse J.; Rogers, Buck E.; Meares, Claude F.; Lapi, Suzanne E.
In: Journal of Nuclear Medicine, Vol. 55, No. 6, 01.06.2014, p. 1029-1034.
Marquez, BV, Ikotun, OF, Parry, JJ, Rogers, BE, Meares, CF & Lapi, SE 2014, 'Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor', Journal of Nuclear Medicine, vol. 55, no. 6, pp. 1029-1034. https://doi.org/10.2967/jnumed.113.130898
Marquez BV, Ikotun OF, Parry JJ, Rogers BE, Meares CF, Lapi SE. Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor. Journal of Nuclear Medicine. 2014 Jun 1;55(6):1029-1034. https://doi.org/10.2967/jnumed.113.130898
Marquez, Bernadette V. ; Ikotun, Oluwatayo F. ; Parry, Jesse J. ; Rogers, Buck E. ; Meares, Claude F. ; Lapi, Suzanne E. / Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor. In: Journal of Nuclear Medicine. 2014 ; Vol. 55, No. 6. pp. 1029-1034.
@article{8fbc8bd32cfe4a029f104eb71e8cbdcc,
title = "Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor",
abstract = "Imaging agents based on peptide probes have desirable pharmacokinetic properties provided that they have high affinities for their target in vivo. An approach to improve a peptide ligand's affinity for its target is to make this interaction covalent and irreversible. For this purpose, we evaluated a 64Cu-labeled affinity peptide tag, 64Cu- L19K-(5-fluoro-2,4-dinitrobenzene) (64Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF) as a PET imaging agent. We compared the in vivo properties of 64Cu-L19K- FDNB in VEGF-expressing tumor xenografts with its noncovalent binding analogs, 64Cu-L19K-(2,4-dinitrophenyl) (64Cu-L19K-DNP) and 64Cu-L19K. Methods: The L19K peptide (GGNECDIARMWEWECFERK-CONH 2) was constructed with 1,4,7-triazacyclononane-1,4,7-triacetic acid at the N terminus for radiolabeling with 64Cu with a polyethylene glycol spacer between peptide and chelate. 1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB. 64Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro. As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP. PET imaging and biodistribution studies of 64Cu-L19K-FDNB, 64Cu-L19K-DNP, and the native 64Cu-L19K were compared in HCT-116 xenografts. Blocking studies of 64Cu-L19K-FDNB was performed with a coinjection of excess unlabeled L19K-FDNB. Results: In vitro binding studies confirmed the covalent and irreversible binding of 64Cu-L19K-FDNB to VEGF, whereas 64Cu-L19K-DNP and 64Cu-L19K did not bind covalently. PET imaging showed higher tumor uptake with 64Cu-L19K-FDNB than with 64Cu-L19K-DNP and 64Cu-L19K, with mean standardized uptake values of 0.62 ± 0.05, 0.18 ± 0.06, and 0.34 ± 0.14, respectively, at 24 h after injection (P < 0.05), and 0.53 ± 0.05, 0.32 ± 0.14, and 0.30 ± 0.09, respectively, at 48 h after injection (P < 0.05). Blocking studies with 64Cu-L19K-FDNB in the presence of excess unlabeled peptide showed a 53% reduction in tumor uptake at 48 h after injection. Conclusion: In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tracer accumulation at the tumor site in vivo, compared with its noncovalent binding peptide analogs. This technique is a promising tool to enhance the potency of peptide probes as imaging agents.",
keywords = "Covalent, Molecular imaging, Peptide, PET, VEGF",
author = "Marquez, {Bernadette V.} and Ikotun, {Oluwatayo F.} and Parry, {Jesse J.} and Rogers, {Buck E.} and Meares, {Claude F.} and Lapi, {Suzanne E.}",
doi = "10.2967/jnumed.113.130898",
T1 - Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor
AU - Marquez, Bernadette V.
AU - Ikotun, Oluwatayo F.
AU - Parry, Jesse J.
AU - Rogers, Buck E.
AU - Meares, Claude F.
AU - Lapi, Suzanne E.
N2 - Imaging agents based on peptide probes have desirable pharmacokinetic properties provided that they have high affinities for their target in vivo. An approach to improve a peptide ligand's affinity for its target is to make this interaction covalent and irreversible. For this purpose, we evaluated a 64Cu-labeled affinity peptide tag, 64Cu- L19K-(5-fluoro-2,4-dinitrobenzene) (64Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF) as a PET imaging agent. We compared the in vivo properties of 64Cu-L19K- FDNB in VEGF-expressing tumor xenografts with its noncovalent binding analogs, 64Cu-L19K-(2,4-dinitrophenyl) (64Cu-L19K-DNP) and 64Cu-L19K. Methods: The L19K peptide (GGNECDIARMWEWECFERK-CONH 2) was constructed with 1,4,7-triazacyclononane-1,4,7-triacetic acid at the N terminus for radiolabeling with 64Cu with a polyethylene glycol spacer between peptide and chelate. 1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB. 64Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro. As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP. PET imaging and biodistribution studies of 64Cu-L19K-FDNB, 64Cu-L19K-DNP, and the native 64Cu-L19K were compared in HCT-116 xenografts. Blocking studies of 64Cu-L19K-FDNB was performed with a coinjection of excess unlabeled L19K-FDNB. Results: In vitro binding studies confirmed the covalent and irreversible binding of 64Cu-L19K-FDNB to VEGF, whereas 64Cu-L19K-DNP and 64Cu-L19K did not bind covalently. PET imaging showed higher tumor uptake with 64Cu-L19K-FDNB than with 64Cu-L19K-DNP and 64Cu-L19K, with mean standardized uptake values of 0.62 ± 0.05, 0.18 ± 0.06, and 0.34 ± 0.14, respectively, at 24 h after injection (P < 0.05), and 0.53 ± 0.05, 0.32 ± 0.14, and 0.30 ± 0.09, respectively, at 48 h after injection (P < 0.05). Blocking studies with 64Cu-L19K-FDNB in the presence of excess unlabeled peptide showed a 53% reduction in tumor uptake at 48 h after injection. Conclusion: In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tracer accumulation at the tumor site in vivo, compared with its noncovalent binding peptide analogs. This technique is a promising tool to enhance the potency of peptide probes as imaging agents.
AB - Imaging agents based on peptide probes have desirable pharmacokinetic properties provided that they have high affinities for their target in vivo. An approach to improve a peptide ligand's affinity for its target is to make this interaction covalent and irreversible. For this purpose, we evaluated a 64Cu-labeled affinity peptide tag, 64Cu- L19K-(5-fluoro-2,4-dinitrobenzene) (64Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF) as a PET imaging agent. We compared the in vivo properties of 64Cu-L19K- FDNB in VEGF-expressing tumor xenografts with its noncovalent binding analogs, 64Cu-L19K-(2,4-dinitrophenyl) (64Cu-L19K-DNP) and 64Cu-L19K. Methods: The L19K peptide (GGNECDIARMWEWECFERK-CONH 2) was constructed with 1,4,7-triazacyclononane-1,4,7-triacetic acid at the N terminus for radiolabeling with 64Cu with a polyethylene glycol spacer between peptide and chelate. 1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB. 64Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro. As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP. PET imaging and biodistribution studies of 64Cu-L19K-FDNB, 64Cu-L19K-DNP, and the native 64Cu-L19K were compared in HCT-116 xenografts. Blocking studies of 64Cu-L19K-FDNB was performed with a coinjection of excess unlabeled L19K-FDNB. Results: In vitro binding studies confirmed the covalent and irreversible binding of 64Cu-L19K-FDNB to VEGF, whereas 64Cu-L19K-DNP and 64Cu-L19K did not bind covalently. PET imaging showed higher tumor uptake with 64Cu-L19K-FDNB than with 64Cu-L19K-DNP and 64Cu-L19K, with mean standardized uptake values of 0.62 ± 0.05, 0.18 ± 0.06, and 0.34 ± 0.14, respectively, at 24 h after injection (P < 0.05), and 0.53 ± 0.05, 0.32 ± 0.14, and 0.30 ± 0.09, respectively, at 48 h after injection (P < 0.05). Blocking studies with 64Cu-L19K-FDNB in the presence of excess unlabeled peptide showed a 53% reduction in tumor uptake at 48 h after injection. Conclusion: In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tracer accumulation at the tumor site in vivo, compared with its noncovalent binding peptide analogs. This technique is a promising tool to enhance the potency of peptide probes as imaging agents.
KW - Covalent
KW - Molecular imaging
KW - Peptide
KW - PET
KW - VEGF
U2 - 10.2967/jnumed.113.130898
DO - 10.2967/jnumed.113.130898


The information presented below gives detailed historical monthly average weather conditions along with exceptional weather occurrences. To maintain relevance to current weather trends the displayed information has been calculated using data collected over the past two decades. The climate profile is taken from closest available data source to Ratoath.
Throughout the month of April daytime temperatures will generally reach highs of around 11°C that's about 53°F. At night the average minimum temperature drops down to around 5°C, that's 40°F.
The average monthly amount of precipitation has been recorded at around 45 mm, that's 2 inches. Throughout the month you can expect to see rain or drizzle falling on 22 days of the month, with snow falling on 2 days.


We've got a tasty dessert for you as this week's Bake of the Week.
This recipe comes from Rosemary Shrager's Cookery Course by Rosemary Shrager, published by BBC Books, priced £20.
First, make the lemon pâtissière. Beat the eggs in a large bowl. Put the lemon juice in a pan with the sugar, place over a low heat to just dissolve the sugar, then bring to the boil. Take the pan off the heat and beat in the butter, then whisk this mixture into the bowl with the eggs.
Pour everything back into the pan, place the pan over a low heat and, very slowly, bring everything to a simmer, whisking all the time. Pour the mixture into a bowl and cover with cling film, making sure the film touches the mixture so condensation cannot form. Set aside to cool.
Fill the pastry case with the lemon pâtissière and arrange the soft fruit on top. Scatter with mint leaves, if using, and dust with icing sugar.


What a great day on the ice and the conditions were awesome! Couldn't have asked for better weather to end the season!
Since this was the last event of the year, we also crowned a 2014/2015 UPL Team of the Year!! This year we had a tie for overall points. Steven Mathews/Juan Arellano and Lawrence Luoma/Michael Thompson tied with 104 points, so it came down to which team weighed the larger crappie throughout the season and Steven Mathews/Juan Arellano are the 2014/2015 UPL Champions! Congrats guys!!
Thank you for all of the support this season and the teams did an amazing job! Already looking forward to next year!!
nice! i was wondering who the crowd was. got down there about 2.


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2018 is going to end, and Google has released the list of the best Android apps this year, which may surprise you. From the company at the end-year list. Google play best apps have been named and surprisingly the app Drops Learn 31 new languages that helps in learning the language has been dominant. This application helps in learning 31 different languages and Google has called it the best app of 2018, as well as the PUBG MOBILE came honors in the best game section.
Google has added other Android apps to these categories.
VIMAGE: This app helps users to edit photos and add annotations.
No.Draw: The nine-star app is for cloning.
Neverthink: Best app is to watch the Internet video.
TikTok: Tiktok is a branded version of Musical.
Scout FM: Best app to listen to FM Podcast.
Slowly: The application called Slowly is an app that helps play with older friends.
Unfold: This app helps to create stores.
Just a Line: Augmented reality drawing app Google has developed itself.
Luci: Is a dream Journal application.
Learn Spanish with Lirica: A best Spanish Learning app.
Mimo: Helps to write app code write.
10% Happier: Is a meditation assistant app.
Keep Trainer: The app offers fitness coaching.
MasterClass: Performs acting, singing and cooking classes.
Tasty: Reins the recipes into social media freelance videos.
Otter Voice Notes: Converts to voice recording by writing it.
Sift: There is a shopping app.
Canva: Helps posters and social media posts.


The National Association of Home Builders (NAHB) Research Center approves certain products as being eligible to contribute points toward certification of a building under the National Green Building Standard™ for homes. NAHBRC issues a Certificate to the manufacturer from NAHBRC, along with the right to use the NAHB Research Center Green Approved mark on approved products. Such products, when appropriately used, enable builders to earn points toward certification of the building. The NAHB Research Center Green Approved mark is intended to assist builders, designers, and specifiers in identifying products that can contribute points toward building certification. The NAHB Research Center Green Approved mark is also intended to facilitate the verification of the "green" practice incorporated into the building during field inspections by providing the accredited verifier with assurance that the product is eligible for the points claimed by the builder.
This program requires that manufacturers provide appropriate third-party evidence that their products meet the criteria for recognition in buildings certified to the National Green Building Standard™. "Green Approved" products carry a certificate from the NAHB Research Center that identifies the specific section(s) of the Standard where points for the product are available.


text:
Exclusive Photos from THE HOST World Premiere
By SUE SCHNEIDER 03/30/2013
Open Road Films held the World Premiere for THE HOST on March 19th at the ArcLight Hollywood Cinerama Dome. Fans were across from where I shot, and on risers and over by the door of the theatre. Subway gave sandwiches out to all the media, fans, stars and everyone else that walked the carpet. T-shirts were handed out to the fans as they waited patiently to get a picture with their favorites and an autograph. THE HOST is a love story from Stephenie Meyer, the creator of the TWILIGHT SAGA, but this time it's about an unseen enemy threatening mankind […]Read On »
Exclusive Interview: TEEN WOLF showrunner Jeff Davis talks Season 2 finale and Season 3
By A.C. FERRANTE 08/13/2012
One of the most engaging and exciting genre series on television is MTV's re-envisioning of the classic 1980s comedy TEEN WOLF. Stripping away the silliness and playing it straight, executive producer and showrunner Jeff Davis has crafted one of the best genre TV shows set in high school since BUFFY THE VAMPIRE SLAYER. With TEEN WOLF concluding its summer season tonight, we caught up with Davis to talk about the Season 2 finale and teases where our titular teen wolf Scott McCall (Tyler Posey) and his makeshift Scooby Pack will be heading in Season 3. ASSIGNMENT X: BUFFY THE VAMPIRE […]Read On »
TV Review: TEEN WOLF – Season 2 – "Battlefield"
By CARL CORTEZ 08/07/2012
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Jeff Davis Director Tim Andrew Network: MTV, airs Monday nights Original Telecast: August 7, 2012 After a full season of one major event after another in a great, long story arc (and little room to breathe), "Battlefield" finally allows TEEN WOLF to put some space between the major Kanima storyline and last week's death of Matt (Stephen Lunsford) who went pretty crazy after he bonded with the Kanima. He wanted revenge, and the Kanima offered that. It wasn't intentional, but it happened. […]Read On »
TV Review: TEEN WOLF – Season 2 – "Party Guessed"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Jeff Davis Director Tim Andrew Network: MTV, airs Monday nights Original Telecast: July 23, 2012 In some ways, it would be nice to have more two hour TEEN WOLF episodes, because then there wouldn't be that inevitable delay of continuity. Then again, having to wait a week for resolutions is a good thing too – it makes you come back for more. After last episode's "Raving", the gang start to get closer to who is the Kanima's Master, and with "Party Guessed", […]Read On »
TV Review: TEEN WOLF – Season 2 – "Raving"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Jeff Davis Director Russell Mulcahy Network: MTV, airs Monday nights Original Telecast: July 22, 2012 The stakes are raised once again with TEEN WOLF in the exceptional new episode "Raving" that sees even more twists tossed into the mix. At the forefront is Jackson (Coloton Haynes) still not understanding he's become a psycho shape-shifting Kanima snake creature being controlled by someone even more nefarious. Scott (Tyler Posey) and his makeshift teen team get closer to the truth and learn that the person […]Read On »
TV Review: TEEN WOLF – Season 2 – "Restraint"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Nick Antosca & Ned Vizzini Director Russell Mulcahy Network: MTV, airs Monday nights Original Telecast: July 9, 2012 Once again, TEEN WOLF continues its feature film quality and delivers another great episode with "Restraint." Of course the title could be further from the truth, since this episode is packed with non-stop action and plot turns. Restraint is the last thing on its mind as all the pieces of a very elaborate puzzle are being laid out with fantastic results. The plot elements […]Read On »
TV Review: TEEN WOLF – Season 2 – "Frenemy"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Jeff Davis Director Russell Mulcahy Network: MTV, airs Monday nights Original Telecast: July 2, 2012 Now that we're safely at the mid-way point of the second season of TEEN WOLF, the story continues to progress in "Frenemy" at a rapid fire pace delivering a great looking and written episode that progresses many of the show's themes, but also delivers a couple more surprises as well. In a way, TEEN WOLF is a 13 hour movie – since there's usually not a lot […]Read On »
TV Review: TEEN WOLF – Season 2 – "Venomous"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Ned Vizzini & Nick Antosca Director Tim Andrew Network: MTV, airs Monday nights Original Telecast: June 25, 2012 It's about time TEEN WOLF started revealing some things, and finally it does with "Venomous", an appropriately titled episode since it reveals a snake (i.e. a new form of shapeshifter) hiding in our core group. After several episodes of teasing, "Venomous" finally offers up the big reveal about half-way through the episode, and while it's not altogether surprising, I'm just relieved it's a major […]Read On »
TV Review: TEEN WOLF – Season 2 – "Abomination"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Christian Taylor Director Tim Andrew Network: MTV, airs Monday nights Original Telecast: June 17, 2012 I hate to say this, because I love TEEN WOLF so much, but the latest episode "Abomination" was about as frustrating as you can get. Yes, it has some great effects, yes, the humor is there, yes I like the characters, but the pacing and the ultimate reveal of what the Shapeshifter looks like was kind of, well, anti-climactic. We still don't know who the Shapeshifter is, […]Read On »
TV Review: TEEN WOLF – Season 2 – "Ice Pick"
Stars: Tyler Posey, Crystal Reed, Dylan O'Brien, Tyler Hoechlin, Holland Roden, Colton Haynes, Linden Ashby, JR Bourne Writer: Luke Passmore Director Tim Andrew Network: MTV, airs Monday nights Original Telecast: June 11, 2012 A war is brewing in TEEN WOLF and the question is – who will be on which side? In the latest episode "Ice Pick", you have Allison (Crystal Reed) discovering from her dad (JR Bourne) that boys are meant to be soldiers, girls are meant to be leaders (which probably explains why Allison's mom is such a scary nut job). Anyway, her dad kidnaps her and lets […]Read On »


Most people use GNU screen (or equivalent) to daemonize processes. There is a better alternative called dtach which should become the definitive way to run a process in the background as a daemon.
-a		Attach to the specified socket.
does not exist, running the specified command.
-c		Create a new socket and run the specified command.
-n		Create a new socket and run the specified command detached.


Air conditioner freon is responsible for cooling your car - it's a key component of your car's A/C. Freon is a halocarbon that cycles through your A/C. Freon is a refrigerant that cycles through liquid and gas phases, and works to regulate the temperature of your car. It is important that there is not an A/C Freon leak in your car's air conditioner system, in order to maintain cool air temperatures in the vehicle's cabin when the air conditioner is on.
If you own a car that was manufactured before 1994, you can have your A/C retrofitted for R-134a Freon. A/C retrofitting is one of Firestone Complete Auto Care's air conditioner repair service. Call or come into your neighborhood Firestone Complete Auto Care store to find out how we can keep you cool in the car, and the environment safe.


August 2018: Design of Creekside Vinyl's stationery (postcards, business and loyalty cards, stickers and website banners).
A newly acquired vinyl store in Faversham (Creekside Vinyl) needed new stationery designed and I was asked if I would like to take the commission. I love this sort of job – to design for a great vinyl store located in a great setting – Standard Quay, Faversham.
My approach was to suggest I take a set of photos of the store and close up shots of records, etc.
These images would be used in conjunction with the designs; it seemed logical to me that imagery would add impact to the designs and give people an idea of what they would find in-store. The store has a friendly and relaxed atmosphere located in a picturesque part of Kent.
The client is delighted with the final designs and feels that it captures the essence of the store well. Please see below for a selection of images from the photo shoot.


text:
50 Random Facts List #73
1Speedy Gonzales
Speedy Gonzales cartoons were banned for a short while by Cartoon Network, due to perceived racial insensitivity. They were brought back after fan campaigns, and the Hispanic-American rights organization League of United Latin American Citizens called Speedy a cultural icon.
2. In China they can count to ten using just one hand using a type of sign that everyone uses. 6 is the western 'hang loose' gesture. 7 a snake head, 8 a finger gun, nine an index finger hook and 10 a cross or closed fist.
3. In 2017, a wedding photographer named Andrea Polito was awarded $1,080,000 in a defamation suit when a couple refused to pay a $125 fee.
4. Researchers in the Netherlands have found that on New Year's Eve, birds fly much higher than normal to avoid the fireworks.
5. Loneliness is a greater health risk than obesity. Loneliness increases the risk of premature death by 50% while obesity increases the risk by only 30%.
Potatoes should never be refrigerated. Not only does it ruin the flavor, it produces high levels of a carcinogen called acrylamide.
7. A domino can knock over another domino that's a maximum of 1.5 times larger than itself. Based on that progression, if you started with a domino the size of a carbon atom, you could knock over the Burj Khalifa with a 1.22-kilometer tall domino in just 74 steps.
8. During the Cold War, playground equipment in the US and the USSR was made with the intent of getting children to be interested in the Space Race.
9. If you choose cremation, you can have your ashes made into a rock to form the base of an "eternal memorial reef" so that you can help coral reefs bloom after you've died.
10. Director Guillermo del Toro owns a house called, 'Bleak House' in which there is a room with a never-ending rainstorm projected onto all windows and audio to match. He often uses this room to write.
11TLC
TLC planned to make a reality show about NASCAR wives but canceled it before airing because the wives got along too well.
12. Although the crew of Mr. Rogers' Neighborhood rarely talked to Fred off the set, and mercilessly made fun of him behind his back, while he was rehearsing with his puppets before each show, these same men would sneak into the studio and ask his puppets for personal advice, which Fred kindly gave.
13. In 480 B.C., King Xerxes I of Persia built bridges to invade Greece. But a storm destroyed these bridges. Enraged, King Xerxes threw chains in the sea, whipped the sea 300 times and burned it with red-hot irons as his men shouted at the water. The next bridge built was not destroyed.
14. 171,000 people perished in 1975 in China due to the collapse of the Banqiao Dam, an event hidden from the world until 2005.
15. After the Colossus of Rhodes snapped at the knees and fell over onto the city after an earthquake, the remains lay untouched for over 800 years. Even broken, the Colossus was so impressive that many people traveled just to see the pieces.
16Bliss
The hill in the Windows XP desktop photo (Bliss) was actually part of a vineyard that had recently been destroyed by a bug infestation.
17. The character Mark from Tommy Wiseau's "The Room" is named after Matt Damon, who Tommy believed was named Mark Damon.
18. The former tallest and oldest Cypress tree (The Senator) on Earth, estimated to be 3,500 years old, was burned down after a woman tried to smoke meth under it.
19. In 2010, a group of US soldiers used to kill teenagers in Afghanistan for fun. Pictures can be seen of them smiling with their "trophy" just like people used to do with wild animal killings.
20. All male Astronauts going to the International Space Station from Russia are required to pee on a bus tire prior to launch, a tradition started by Yuri Gagarin.
21Phosphenes
The trippy patterns that you see when you shut your eyes tightly are called phosphenes. They are caused by electrical charge produced in the retina and/or mechanical stimuli such as rubbing your eyes.
22. In 532 A.D., 30,000 rioters were killed and half of Constantinople was destroyed in the Nika Riots, over a conflict with chariot racing.
23. You don't forget things you did when you were drunk, your brain just never recorded the memories as the events happened.
24. In 2017, a Florida man shot neighbor's cat because it 'looked at him like he owned the place'.
25. Thomas Edison paid his son Thomas Edison Jr. an allowance of $35.00 a week ($925.25 in 2017) to not use the Edison name to sell his snake oil products.
Kath January 8, 2018 at 6:47 pm
As a longtime resident of NJ, I can clarify that it is not illegal to pump your own gas. In fact, if you don't, you'll be out of luck (and gas). 😉.
What are you talking about, no one pumps their own gas in NJ, they have attendants! And it has been a state law since 1949, look it up! Millions of New Jerseyans can back this up, so for all of them I say " Fuggedaboutit, you friggin idiot!!"


text:
"Playing extreme characters, characters that are hard to portray or things that challenge you personally.... that's keeping your edge. Because you don't know what you're doing" -Russell Crowe on acting
LUCKY 7: DVD
Amy (Kimberly Williams-Paisley) is a beautiful and successful lawyer intent on following the guidelines her mother left her before she died when Amy was only 7 years old. Boyfriend Number 7 is supposed to be the Real Deal, but when Amy meets Daniel (Brad Rowe), who is perfect for her in every way, she is in a panic, because he is only her 6th boyfriend. Amy decides to find an interim boyfriend, who she can label number 6, so the 7th spot is saved for Daniel, and finds Peter (Patrick Dempsey), the manager of a bagel shop she frequents.
It's predictable but nicely so, this engaging romantic comedy with compelling leads that reminds us of the value of spontaneity. Kimberly Williams-Paisley and Patrick Dempsey are unlikely lovers who become the perfect match in Lucky 7, a made for television rom-com in which a make-believe weekend becomes the basis for a credible future.
Williams-Paisley's Amy was only 7 years old when her mother died, but the successful young lawyer kept her guiding timeline as a reassurance for the most important events of her life. When we first meet the grown up Amy, she has just broken up with her 5th boyfriend. Enter Daniel (Brad Rowe), who she meets at the tennis club, when waiting for a blind date. 'He's the one: he's perfect,' says her Dad. There are even fireworks when they kiss for the first time and Amy is convinced that her fate is sealed. But her obsession with her mother's timeline plays with her mind, prompting Amy to accept the invitation from the bagel-shop guy Peter (Patrick Dempsey) to be his date at an out of town wedding.
Of course we know from the outset that Peter and Amy are perfect for each other, when they set out together on the ferry to take them to their out of town destination. For once, there's a spontaneity to the events that Amy has never had before as they play croquet and go kayaking together. She even tells him something she hasn't ever told anyone else about - that she hates her job. They hold hands for show and make up stories about their first date for Peter's friends; when he says 'who says we won't last?' as they kiss in the moonlight and fall into bed together, it is clear that make believe has turned into the real thing.
There are ups and downs as the relationship works itself out, but we are never in any doubt as to the outcome. The two leads exude plenty of chemistry as their relationship goes from cold to hot. It's hard to define what is Dempsey's appeal, but it is there in sparkling colour as cupid shoots its arrows and Lucky 7 is The One.
LUCKY 7: DVD (PG)
(Canada, 2003)
CAST: Kimberly Williams-Paisley, Patrick Dempsey, Brad Rowe, Brian Markinson, Lochlyn Munro, Michelle Harrison, Jennifer Copping
PRODUCER: Judy Cairo
DIRECTOR: Harry Winer
SCRIPT: Jessica Barondes
CINEMATOGRAPHER: Jon Joffin
EDITOR: David A. Simmons
MUSIC: Danny Lux
PRODUCTION DESIGN: Jerry Wanek
PRESENTATION: 4:3
SPECIAL FEATURES: None
DVD DISTRIBUTOR: TimeLife
DVD RELEASE: November 1, 2008


If you didn't fall prey to the timeshare scam yet, keep reading. You may get something out of my story. I love traveling and if you are like me, you must have heard somehow about the timeshare industry. Chances are that at some point you might have even been approached by some intrusive salesmen, trying to lure you into a timeshare presentation. And I'm sure he made it sound like an easy way to win a couple of hundred dollars for just an hour of your vacation time. Let's face it, traveling is not cheap so who can't use some extra money when traveling? In this article I will share with you my 14-year experience as a timeshare owner and try to expose the timeshare scam.
In our case it wasn't even the easy reward that convinced us to attend that timeshare presentation. Owning a piece of paradise in a hotspot vacation property in Hawaii sounded heavenly. We all know how difficult it is to find a decent hotel room at an affordable price these days. If for the price of a mediocre hotel room we could stay in a clean, well maintained condo, why would we say 'no'?
Back in the summer of 1998 while vacationing in Hawaii, my husband and I have been approached by a salesman from Shell Vacations Club and lured into a timeshare presentation. At the time the Internet was at an early stage and the information about timeshares was scarce.
The sales presentation was pleasant and informative and seemed to make perfect sense. Newly immigrated from Europe with a young son and not much money on our hands, we knew we couldn't afford to buy property in Hawaii or somewhere else. On the other hand, with hotel prices always on the rise it seemed that a timeshare investment would always keep us ahead of the game. Oh, did I say investment? I guess I did, but little did we know at the time that it would rather be a money pit. So two months and a $18,000 later, we were the proud owners of a timeshare on the Big Island of Hawaii. Lucky us!
Most timeshare purchases are deeded, or "fee simple"). This means that the purchaser is buying an actual share of ownership in the resort. Non-deeded timeshares, also known as right-to-use, certificate or vacation-interval timeshares, are more like a club membership. But no matter what shape or form, all timeshare resorts charge an annual fee for maintenance, utilities and taxes. Resorts can increase the fees each year. The initial fees at the time you buy are not locked in and that's where the big catch is. We had a two-week share of ownership for which our annual fee was around $1,400. At the time of the presentation we addressed our concerns regarding the yearly increase in this fee but have been assured that, as owners, we will always have a say in it.
The first few years into our ownership we were pretty happy with our deal. Every year we kept coming to Hawaii bringing family and with us and even going on different islands. But even from the beginning we noticed that the top floor units, or the ones facing the ocean were never available. They always seem to have been snatched from under our nose by somebody who arrived earlier. Even more, the only units available on our arrival were always on the ground floor. Even worse. They were facing the garage, the noisy swimming pool area, or the trash collecting area. I can't remember a single time in almost 14 years when we did not have to change units at least two times before receiving something barely decent. So our vacations were always starting with arguments, complaints and repeated trips to the reception desk. All those nice, smiling, and helpful selling agents that roamed the resort grounds on our presentation day seemed to have mysteriously vanished.
As time went by we grew less and less fond of our timeshare deal. Not only had we not purchased a piece of paradise, but our "deal" was turning into a liability. More and more fees began to appear every year. If we could not use our time on a certain year we had to pay a $25 fee to bank it for the following year, or loose it. We could make one free reservation a year. For the subsequent ones they would charge us a $25 fee/reservation. If we stayed for two weeks in a resort, the first cleaning fee was free but the second wasn't. So if we wanted our towels and bedding changed and the room cleaned, we had to pay another $50. Other fees included: resort fee ($100-$150), air conditioning/heating fee (depending on the usage), parking fee ($10-$20/night), exchange fee ($150-$170).
After our son went off to college, we started traveling at less busy times of the year hoping to have a better chance at nicer units, but that didn't turn out any better. After some research, we learned that resorts save their best units for cash rentals (not foolish timeshare owners, like us!) And to add insult to injury, they even rent them for less than our yearly maintenance fees cost.
Last year we finally decided that it was time to get rid of our beloved timeshare, even at a loss. To our dismay, we found out that nobody wants to buy it. Even worse, nobody wants it even gifted! And why would they? It's a liability. We even tried to donate it to some non-profit organizations that could use it for fund-raisings. But they turned us down too.
Considering the struggling economy in the past years and ever increasing maintenance fees, sellers outnumber buyers by a huge margin. This has driven the prices of resales down to levels never before seen in this industry. Some timeshares have depreciated over 99%. It's quite common to see timeshares listed for a single dollar, because people just try to get rid of them. They are only looking to get rid of their annual maintenance fees! Unfortunately, the demand side for resales is just as bad. Most people don't even know there is a resales market available until after they buy from the developer. Why else would anyone buy them from the developer if they could get the exact same thing for a fraction of the price?
In most cases a contract rescission is not even an option. If you stop paying your maintenance fees you can be sued and have your credit ruined. Fortunately for us, our contract included a provision for cancellation, which is extremely rare in the industry. In the end, we forfeited out certificate of title and all our points and got out of the deal without having to hire an attorney. I guess we were lucky after all. But I have to admit that we learned a good lesson for the price of $18,000.
Are you a victim of the timeshare scam ? Please share your experience in the comments section below.
Ugh. This topic makes my blood boil. My husband and I were suckered into purchasing a timeshare during our honeymoon in Cabo San Lucas. I was skeptical from the beginning but he was very excited about the prospect and, being newly married, why wouldn't I want to agree to something that would make my husband happy? We never did get back to "our" unit in Cabo San Lucas, but we were able to trade our week for time in a beautiful house in the North Carolina mountains. Still, not worth the money we'd already put forth. That's when we decided to sell it and everything went south from there. On the other hand, we have friends with a timeshare and they are in love with it. So, perhaps it's a dice roll.
The ones who are "happy" with their timeshares are usually those whose travel destinations and vacations schedules are dictated by the availability of the timeshare.
Ah, so sorry to hear that Anda but thank you for sharing your story for others to learn from. I have heard mixed reviews, mostly bad, from people who ended up getting timeshares in various locations. Now we all know to stay away!
I hope my experience will help other stay away from this trap, Alyssa.
I think timeshares are a waste at the end of the day. I went on a tour of them a couple of times solely for the purpose of free things. They really sell you, but for all of that you can just buy a place and turn it into a rental property when your not there.
I agree, Holly. I learned my lesson the hard way.
During our earlier travel years we used be tempted into the timeshares and have sat through a couple of the 'Investment' presentations, and listened to the pushy sales people. Glad we didn't get sucked into it. You probably can find better deals for that maintenance cost payment!
Timeshares have been consistently known for different things: some positive, but most of them are very negative, which has created a smokescreen around the whole idea of timeshares. There are many timeshare owners who feel joyful with their purchases, but there are even more who regret having bought a timeshare, and want to get rid of it at all costs.
Thank you for your comment, Brittany. I hope you didn't have a negative experience with a timeshare.
Thank you for your comment, Brittany. From what I understand you work for a company that actually helps people get out of their nasty timeshare contracts. I'll make sure I'll recommend your company to "unhappy" timeshare owners that I may hear about.
Thank you for your comment, Melanie. I wish more people like you would reveal the scam of the timeshare industry.


Riviera Australia will be closed from April 19 to April 28. We will re-open on Monday April 29th.
If your enquiry is of an urgent nature, please contact your nearest Riviera and Belize Representative during this time.


Although the Lamprey Nervous System is much more similar to ours, the Amphioxus Nervous System is interesting, so I'm going to start there.
The long list of links in "Cross references", above, to pages in Children of the Amphioxus is intended to provide general background to amphioxus locomotion.
Also: Amphioxus Evolution and Amphioxus Fast-Slow Twitch .
See: Dorsal Motor Neurons .
Please see: Ventral Motor Neurons .
Please see: Amphioxus Glutamate .
The cholinergic gene locus in amphioxus: molecular characterization and developmental expression patterns.
"Amphioxus has three types of motoneurons, ventral compartment (VC) motoneurons, which innervate the fast fibers of the myotome, dorsal compartment (DC) ones, which innervate the slow fibers, and visceral motoneurons, which innervate all other body muscles "
Searching Google for "fast twitch muscles" yielded 1,120,000 claimed hits. Are human fast and slow twitch muscles innervated by different nerves?
See: Muscle Innervation and Amphioxus Fast-Slow Twitch .


text:
Q: how to use Prolog with J2EE for develop web application I am trying to develop the Web Application with Prolog, But SWI-Prolog is not supported with Java for a Web application.
Please suggest some other Prolog IDE's for web development.
When I am using SWI-Prolog in J2EE application (Web application), It works only for one instance because it is a desktop application if I open my localhost in other browser or private browsing, it shows error and throws exception

redpajama_set_name: RedPajamaStackExchange


text:
Q: Basic question on Galois connections Let $X,Y$ be two posets, and let $f:X\to Y$ and $g:Y\to X$ be two maps giving rise to an antitone Galois connection. Assuming that $X,Y$ are lattices, how do I prove that meets and joins are reversed by $f$? (I'm stuck with one of four inequalities).

*

*$f(x\wedge x')=f(x)\vee f(x')$. I could prove one direction: $x\wedge x'\leq x,x'$, so $f(x\wedge x')\geq f(x),f(x')$, and by the universal property $f(x\wedge x')\geq f(x)\vee f(x')$. I don't get how to prove the converse though; would you only give me a hint?

*$f(x\vee x')=f(x)\wedge f(x')$. Similarly to above $f(x\vee x')\leq f(x)\wedge f(x')$. Conversely $f(x\vee x')\geq f(x)\wedge f(x')$ $\iff$ $x\vee x'\leq g(f(x)\wedge f(x'))$. By symmetry $g(f(x)\wedge f(x'))\geq gf(x)\vee gf(x')$, so it is sufficient that $x\vee x'\leq gf(x)\vee gf(x')$, which is easy to show.


text:
Vineland High School crew team wins race for $500 grant
VINELAND – Utilizing the power of social media, the Vineland High School crew team won a $500 voucher to purchase equipment from the Nielsen-Kellerman sports equipment company, according to new coach Jeannine McCarty.
The team entered a contest sponsored by NK, submitting a grant application that was accepted as one of 20 finalists. At that point, a team photo was added to an NK Facebook page, and then it was up to the team's supporters. The contest called on entrants to try to get the most Facebook likes for their photos.
McCarty contacted the school district communications department, which shared the direct link to the photo via email, the district website, its Facebook page and its Twitter feed. The initial posting on Facebook initially had nearly 1,800 hits, and from there it was shared by many others.
By the final weekend prior to the March 2 deadline, Vineland was still close but not locked in the top 10. But a final email blast and social media push guaranteed the Fighting Clan one of the $500 vouchers and a chance to go online shopping.
"Social media played a huge role in helping us (win the grant)," McCarty said. "I would not have been able to reach the 400-plus individuals we needed in order to help us succeed. This enabled myself, my rowers' family, and the school district to spread the word to those around us. We are greatly appreciative to everyone who helped these teens hopefully achieve their full potential by using this new equipment."
McCarty said she's not sure how the funds will be spent. "It will probably be a new microphone system to help both boys and girls because currently we have five boats with only four boxes," she said.


The coating compounds are made up of various elements such as carbides, nitrides, borides and silicide. A wide variety of colors can be achieved by adding different gases during the deposition.
PVD coating is one of the best methods for enhancing thin film plating elements. The vacuum deposition method coats the product with a film of hard refractory material 1-2 microns thick.
PVD coatings surpass traditional electroplated coatings, it's more corrosion resistant and have superior hardness.
PVD coatings do not discolor or tarnish, and do not suffer under UV radiation so easy.
WHY CHOOSE STANCH PVD COATING?
Stanch innovate new technique to make the PVD colored coats much harder and more durable than others. The general coating deposition method coats the product with a film of hard refractory 1-2 microns thick, but we make it thicker for better wear, scratch and corrosion resistance making its durability superior to general coating methods such as electroplating or other PVD processes. Stanch new PVD technique can be achieved smooth PVD coat with good scratch resistant compared to other PVD processes as well.
We are continuously researching and developing the process to add more colors. If there is a particular color that you're interested in developing, please don't hesitate to contact us.


It's been a whole week since I moved into my new one bedroom apartment. A whole week since the grueling 72-hour weekend in which my dad and I (who am I kidding – it was mostly my dad) packed, unpacked, built, arranged, and rearranged an entire apartment. It was exhausting. We laughed. We cried. We shrugged our shoulders and said "it is what it is" a lot. We quoted random movies out of context and spoke in strange accents once we reached what I like to call "teenage girl sleepover mode," the point of delirium. We ate at the same nearby diner three meals in a row – when we remembered to eat. I physically ached. I needed a weekend from my weekend.
But once it was all said and done, set up exactly how I (how I and nobody else!) liked it – I felt an overwhelming sense of peace.
My dad left, the dust settled, the remaining two boxes of knickknacks and jewelry could wait to be unpacked (are still waiting to be unpacked). Finally, in the midst of all the chaos that has been my life the last month, I took a deep breath, and smiled.
I was in my little oasis in the city, a place to grow and thrive and heal and relax, to create new memories doing the things I love, simply because they make me happy. The apartment is a blank page for me to fill with the people and objects and memories that I choose – I am both author and editor.
Of course living alone is definitely an adjustment, albeit a welcomed one. Here are a few such adjustments that I've come across in making the transition from resigned roommate to satisfyingly single.
When I walk in the door after a long day and turn on the lights to the kitchen, there are absolutely NO surprises. No dishes piled in the sink, no paperwork strewn on the tabletop, no roommates blasting music, cooking in the kitchen, or hosting unexpected guests. The house is exactly as clean – or as messy – as I left it.
I once had a roommate who wanted to know literally every. single. time. that anybody – including my boyfriend – was going to be over because she didn't like surprises (see above). I get it; it's the considerate thing to do, a courtesy, something you should do if you have a roommate, and if the shoe were on the other foot I'd probably want some sort of advanced notice as well. But after what seemed like the 200th "Hey, just wanted to give you a heads up that…" text, I got tired of it. I am an ADULT. I stopped asking my parents for permission 8 years ago, and I shouldn't feel like I need to get the okay to have my boyfriend – or friends, or house guests, or anyone for that matter – over to my apartment. Not to mention that it killed any sort of spontaneity. Now I can basically do all of the above things without fear of repercussion or the need to "check in" with somebody else and their schedule.
I'm pretty sure I mentioned this in my last post about moving, but I used to have crazy roommates from Berlin who would cook extremely elaborate, extremely involved, and extremely messy meals starting at 10:00 at night. Not only would they frequently begin cooking as I was getting ready to go to bed; but they had an uncanny knack for cooking at literally the EXACT same time that I would come home to cook a meal. In other words, they would either cook late at night or at the exact same time as me. If I went to work early and got home by 5:00, they would be there, cooking. If I went in late, had a happy hour drink with a coworker, and got home at 8 to begin dinner, they would be there, cooking. If I randomly decided to cook a late lunch/early dinner on a Saturday at 4:00pm, they would inevitably be in the kitchen cooking their own late lunch/early dinner on Saturday at 4:00pm. This might not seem like a huge deal, but it is for a couple reasons, namely: (1) NYC kitchens are freaking SMALL. Try maneuvering around it when you're one person, let alone three. (2) Cooking, for me, is a relaxing way to unwind – adding roommates diminishes the relax factor to zero, and increases the stress levels and small talk that one tries to escape via cooking to a hundred. (3) You feel obligated to share your (or try their) food – or worse, eat at the communal table when in reality all you really wanna do is take your stir fry to your bedroom and watch the next episode of The Mindy Project like the true antisocialite you are.
I can play music (almost) as loud as I want, whenever I want.
If I want to wake up and blast "Walking on Sunshine" while I take my shower, I'm totally free to do that. I can sing like the white girl that I am to my standard go-to early-2000s hits, cry with Amy Winehouse, or cheese it out with my favorite "French sidewalk cafe" or Frank Sinatra stations on iHeart Radio. No one can judge my famously terrible taste in music. Or the fact that I listen to iHeart radio. Or ask me to turn it down. Like wayyyy down. And I'm not just talking about lowering the volume on my iPad.
I'm sure you're starting to see a common theme here about me being able to do things whenever I want. I suppose that this entire post could be summed up in "doing the eff whatever, whenever, and wherever." But this one is important. After years of negotiating shower times and coming up with elaborate bathroom schedules with roommates, where "I'll take the bathroom from 7:00-7:15, then you get it from 7:15-7:42, then I'll take it again from 7:42 to 8:03 because it takes me exactly 21 minutes to do my hair," only to have the schedule thrown off because, you know, life, I can't even begin to tell you how refreshing it is to wake up and know that I won't be faced with the passive-aggressive rat race that is getting ready to go to work. I don't have to say hello in the morning before I've had my coffee, and I don't have to get up earlier than I'd like in order to accommodate somebody else's bathroom usage. On that same note, I know that I can come home from a concert at midnight and shower away the smell of sweaty bodies and cigarettes at midnight without fear of waking anybody up. If I go out to a spicy Ethiopian restaurant for dinner and all hell breaks loose, there's no competition for the commode. Likewise, if I unexpectedly get stuck on a train (hello, NY) for an hour right after drinking a large coffee and two bottles of water, I'm in the clear as soon as I get home. I can even leave the door open.
Heck, who even cares about doors at all anymore?
I'm not sure if this has to do with the fact that I'm alone as much as the fact that I am adjusting to a new apartment with new sounds and new quirks. Like the neighbor who ordered takeout sushi on speakerphone and the server who asked him if he wanted a side of edamame to go with that. Or the dog who barks at anyone and anything that happens to breathe near the apartment. Or the fact that at times it can be really freaking weird not to sleep with a door. Of course it's better than the raging frat boys I used to live next to and the forgetful property manager who seemed to forget he had properties to manage. Life is all about the trade-offs.
Yay, no more coming home and finding out that your roommate used up all of the tinfoil or the last roll of toilet paper! Boo, you used up the last roll of tinfoil and have been using Kleenex for two weeks. And you just used your last tissue this morning to fix your makeup. How gratuitous!
Love, love, love reading what you write! Thanks for sharing!
All of the above is sooooooo true. Until you get married. 😉 So enjoy it while you can!
Also, we highly recommend a noise machine for sleeping. It somehow fills the space so it never gets weirdly quiet, but also masks most annoying street noise. We can't live without ours!
Hahaha, that's what I hear! I will definitely enjoy being queen of the roost until then 😉 Also thank you SO much for the tip! That's a great idea – I keep a little fan on, but it doesn't block some of the echo-y hallway noises (slamming doors, barking dogs) that happen throughout the night. Will definitely look into it!


text:
Antoni Niemancewicz SJ (; ur. 8 lutego 1893 w Petersburgu, zm. 6 stycznia 1943 w Mińsku) – białoruski duchowny katolicki, jezuita, doktor teologii, egzarcha Białoruskiego Kościoła Greckokatolickiego w latach 1940–1943.

Życiorys
Absolwent Akademii Duchownej w Sankt Petersburgu. Po I wojnie światowej jako kapłan rzymskokatolicki za swoją gorliwą działalność duszpasterską był prześladowany w Rosji sowieckiej. W 1919 roku został aresztowany przez władze bolszewickie i trafił do więzienia. W 1925 roku w drodze wymiany więźniów przyjechał do Polski. Następnie wyjechał do Rzymu, gdzie w latach 1925–1927 odbył studia doktoranckie w Papieskim Instytucie Wschodnim. W 1928 roku został wykładowcą na Katolickim Uniwersytecie Lubelskim. W 1929 roku przeszedł z obrządku łacińskiego na bizantyjski. Wstąpił do klasztoru jezuitów w Albertyniu.

Jako jezuita prowadził działalność misyjną w ramach Kościoła neounickiego w Polsce. W latach 1932–1939 był redaktorem czasopism kościelnych Da Złuczeńnia i Złuczeńnie, w których propagował odrodzenie świadomości narodowej wśród Białorusinów. Od 1929 roku proboszcz parafii greckokatolickiej w Albertyniu, a od 1933 roku proboszcz parafii greckokatolickiej w Synkowiczach, wykładowca teologii pastoralnej Papieskiego Seminarium Wschodniego w Dubnie.

W 1939 roku po zakończeniu kampanii wrześniowej, wcieleniu Kresów Wschodnich do ZSRR i rezygnacji ze stanowiska egzarchy Wołynia, Podlasia i Polesia, Mikołaja Czarneckiego stanął na czele Kościoła greckokatolickiego na Białorusi. 17 września 1940 roku został mianowany przez arcybiskupa lwowskiego, Andrzeja Szeptyckiego egzarchą Białoruskiego Kościoła Greckokatolickiego z siedzibą w Albertyniu. 5 stycznia 1942 roku otrzymał dla swojej misji zatwierdzenie papieskie. Pozwoliło mu to na krótko wznowić legalną działalność Kościoła neounickiego na terenach Białoruskiej Socjalistycznej Republiki Radzieckiej okupowanych przez wojska niemieckie.

W lecie 1942 roku został aresztowany przez Niemców. Zmarł 6 stycznia 1943 roku śmiercią męczeńską w szpitalu więziennym Sicherheitsdienst w Mińsku.

Przypisy

Zobacz też
 Czesław Sipowicz
 Ukraińska cerkiew greckokatolicka w latach 1939–1941

Linki zewnętrzne
 Antoni Niemancewicz, Bolszewizm a wychowanie w bibliotece Polona

Urodzeni w 1893
Zmarli w 1943
Białoruscy duchowni greckokatoliccy
Duchowni neouniccy
Ludzie urodzeni w Petersburgu
Białoruscy teolodzy katoliccy
Białoruscy jezuici

redpajama_set_name: RedPajamaWikipedia


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Q: redis expiration notifications and flask I'm trying to implement a heartbeat mechanism in Flask via redis (since I'm already using it for a bunch of other stuff already).
When a GET request is received, my Flask app sets an expirable redis variable A. Multiple GET requests resets the expiration time of A. When A truly expires, I need to modify a whole bunch of other redis variables.
Do I need to setup another redis client acting as a SUB running in the background to detect the expirations? Is there a way to do this directly in the same Flask webapp client?

A: You will need another client in background listening to the key expiration notifications. Also note that this feature is only present in Redis 2.8. So if you are using a previous version you will need to handle the notification yourself. There is a lengthy explanation about the alternatives in this StackOverflow post.


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District 2 Supervisor Candace Andersen
Candace was elected to the Contra Costa County Board of Supervisors on June 5, 2012 and sworn in on June 26, 2012 to begin serving her first term as the District 2 Supervisor. She serves as Chair of the Board of Supervisors for 2016. Previously, Candace was on the Danville Town Council from 2003 through June 25, 2012, serving two terms as Mayor. In her role as County Supervisor, Candace currently sits on the following boards, commissions and committees:
Internal Operations Committee
Family and Human Services Committee
Hiring Outreach and Oversight Committee
Transportation, Water and Infrastructure Committee
Contra Costa County Fire Protection District Board
Contra Costa County Housing Authority
Contra Costa County Employee's Retirement Association (CCCERA)
Central Contra Costa Transit Authority – County Connection
Central Contra Costa Solid Waste Authority
Association of Bay Area Government (ABAG)
Hazardous Waste Management Facility Allocation
Southwest Area Transportation Committee
San Ramon Valley Emergency Preparedness Citizen Corps Council
Tri-Valley Transportation Council
Traffix
Street Smarts
East Bay Economic Development Alliance for Business
East Bay Regional Communications System (EBRCSA) Governing Board
Pleasant Hill BART/Contra Costa Centre Joint Powers Authority Board of Trustees
Alternate on regional committees; Bay Area Counties Caucus, Contra Costa Transportation Authority, First 5 Children and Families Commission, TRANSPAC
Candace served on the Morgan Hill City Council in the early 1990's. She is an attorney licensed to practice law in California and Hawaii. She began her legal career as a Prosecuting Attorney in her hometown of Honolulu and worked as a civil practitioner with a law firm in Morgan Hill. Candace put her legal career on hold to serve the community and raise her family.
Candace received both her B.A. in Public Policy (1982) and Juris Doctorate (1985) from Brigham Young University. She attended Punahou School in Honolulu, Hawaii from Kindergarten through 12.
Along with her responsibilities on the Board of Supervisors, Candace remains an active volunteer in her church and community.
She and her husband, attorney Philip M. Andersen, have been married for 34 years and are the parents of six children ranging in age from 19 to 32, have three daughters-in-law, a son-in-law, and five grandchildren.
District 2 Home
Which District am I in?
District II Community Links
Community Advisory Boards


Gone are the days of occasional link ups with friends at coffee bars, because with the change in lifestyle patterns, everyone is making plans beyond the "catch up over coffee." Groups of friends have now taken to organising themselves to experience life outside of their comfort zones, and this is what life has come to mean for most-exploring and making memories with those closest to you, in places you sometimes only imagined.
A few minutes spent on social media will have you bitten by the travel bug, looking at your peers checking into this-and-that place, tagging this-and-that person, ultimately leaving you with a mild case of FOMO (Fear of Missing Out).
Before you know it, you too will be living it up at a cool destination, with great picturesque blue waters, making memories of a lifetime with those closest to you, and how great is it that you can do all this through a Travel Club or a Stokvel, as we love to call it?


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Q: 'if' statement with multiple conditions So I'm making a converter app, and I ran into a problem when using if statements to calculate my answer. I have a UIPickerWheel to select convertFrom and convertTo, and a textField for input.
My problem is that, using below mentioned code, the answer label just displays random units, not the ones selected in the pickerWheel.
I think that my fault is the if statements not checking for both to be the same thing, just one of them. How do I make it check for both to be true, or do it in a proper way?
Download for full project
Code:
#pragma mark -
#pragma mark PickerView Delegate
-(void)pickerView:(UIPickerView *)pickerView didSelectRow:(NSInteger)row
  inComponent:(NSInteger)component
{
    float convertFrom = [[_convertRates objectAtIndex:[pickerView selectedRowInComponent:0]] floatValue];
    float convertTo = [[_convertRates objectAtIndex:[pickerView selectedRowInComponent:1]] floatValue];
    float input = [inputText.text floatValue];
    float to = convertTo;
    float from = convertFrom;
    float convertValue = input;
    float mtpaTilMtpaFloat = convertValue * 1;
    float mtpaTilMMcfdayFloat = convertValue * 2;
    float mtpaTilMillSm3dayFloat = convertValue * 3;
    float mtpaTilMMBTUFloat = convertValue * 4;
    float mtpaTilPJPAFloat = convertValue * 5;
    float MMcfdayTilmtpaFloat = convertValue * 0.5;
    float MMcfdayTilMMcfdayFloat = convertValue * 1;
    float MMcfdayTilMillSm3dayFloat = convertValue *6;
    float MMcfdayTilMMBTUFloat = convertValue *7;
    float MMcfdayTilPJPAFloat = convertValue *8;
    float MillSm3dayTilMTPAFloat = convertValue /3;

    NSString *mtpaTilmtpa = [[NSString alloc ] initWithFormat:
                             @" %f MTPA = %f MTPA", convertValue, mtpaTilMtpaFloat];

    NSString *mtpaTilMMcfday = [[NSString alloc ] initWithFormat:
                                @" %f MTPA = %f MMcf/day", convertValue, mtpaTilMMcfdayFloat];

    NSString *mtpaTilMillSm3day = [[NSString alloc] initWithFormat:
                                   @" %f MTPA = %f Mill.SM3/day", convertValue, mtpaTilMillSm3dayFloat];

    NSString *mtpaTilMMBTU = [[NSString alloc] initWithFormat:
                              @" %f MTPA = %f MMBTU", convertValue, mtpaTilMMBTUFloat];

    NSString *mtpaTilPJPA = [[NSString alloc] initWithFormat:
                             @" %f MTPA = %f PJPA", convertValue, mtpaTilPJPAFloat];

    NSString *MMcfdayTilmtpa = [[NSString alloc] initWithFormat:
                                @" %f MMcfday = %f MTPA", convertValue, MMcfdayTilmtpaFloat];

    NSString *MMcfdayTilMMcfday = [[NSString alloc] initWithFormat:
                                   @" %f MMcfday = %f MMcfday", convertValue, MMcfdayTilMMcfdayFloat];

    NSString *MMcfdayTilMillSm3day = [[NSString alloc] initWithFormat:
                                      @" %f MMcfday = %f MillSm3day", convertValue, MMcfdayTilMillSm3dayFloat];

    NSString *MMcfdayTilMMBTU = [[NSString alloc] initWithFormat:
                                 @" %f MMcfday = %f MMBTU", convertValue, MMcfdayTilMMBTUFloat];

    NSString *MMcfdayTilPJPA = [[NSString alloc] initWithFormat:
                                @" %f MMcfday = %f PJPA", convertValue, MMcfdayTilPJPAFloat];

    NSString *MillSm3dayTilMTPA = [[NSString alloc] initWithFormat:
                                   @" %f MillSm3day = %f MTPA", convertValue, MillSm3dayTilMTPAFloat];

    if (from = 1, to == 1) { resultLabel.text = mtpaTilmtpa;
    }
    if (from = 1, to == 2) { resultLabel.text = mtpaTilMMcfday;
    }
    if (from = 1, to == 3) { resultLabel.text = mtpaTilMillSm3day;
    }
    if (from = 1, to == 4) { resultLabel.text = mtpaTilMMBTU;
    }
    if (from = 1, to == 5) { resultLabel.text = mtpaTilPJPA;
    }
    if (from = 2, to == 1) { resultLabel.text = MMcfdayTilmtpa;
    }
    if (from = 2, to == 2) { resultLabel.text = MMcfdayTilMMcfday;
    }
    if (from = 2, to == 3) { resultLabel.text = MMcfdayTilMillSm3day;
    }
    if (from = 2, to == 4) { resultLabel.text = MMcfdayTilMMBTU;
    }
    if (from = 2, to == 5) { resultLabel.text = MMcfdayTilPJPA;
    }
    if (from = 3, to == 1) { resultLabel.text = MillSm3dayTilMTPA;
    }
}

Thanks.

A: You only have a single = in most of your statements. You should be using a double equals (==). A single = is going to assign the value to from, not check for equality. I would also replace the , with &&. One final thing to do is to combine the common parts of the if statements.
if (from == 1) {
    if (to == 1) {
        resultLabel.text = mtpaTilmtpa;
    }
    else if (to == 2) {
        resultLabel.text = mtpaTilMMcfday;
    }
    else if (to == 3) {
        resultLabel.text = mtpaTilMillSm3day;
    }
    else if (to == 4) {
        resultLabel.text = mtpaTilMMBTU;
    }
    else if (to == 5) {
        resultLabel.text = mtpaTilPJPA;
    }
}
else if (from == 2) {
    if (to == 1) {
        resultLabel.text = MMcfdayTilmtpa;
    }
    else if (to == 2) {
        resultLabel.text = MMcfdayTilMMcfday;
    }
    else if to == 3) {
            resultLabel.text = MMcfdayTilMillSm3day;
    }
    else if (to == 4) {
        resultLabel.text = MMcfdayTilMMBTU;
    }
    else if (to == 5) {
        resultLabel.text = MMcfdayTilPJPA;
    }
}
else if (from == 3 && to == 1) {
    resultLabel.text = MillSm3dayTilMTPA;
}

A: Your use of all of these if statements doesn't scale well. You should have an array of arrays containing the labels. Then use the selected picker rows from the two components to access the elements from the arrays. Then all of your if statements get reduced to something like 3 lines of code.