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MER/29 fue un medicamento cuya principal finalidad era tratar el colesterol en la sangre (agente hipolipemiante). Fue introducido al mercado de Estados Unidos a principios de la década de los 60 por el laboratorio Richardson-Merrell y retirado en 1962 debido a que fue asociado con la formación de cataratas irreversibles. El principio activo era triparanol, una amina cuaternaria referida como inhibidor distal de la biosíntesis de colesterol pues impide el paso final del metabolismo del colesterol al evitar la conversión de desmosterol a colesterol.

El medicamento afectó la visión de más de cinco mil personas provocando muchos casos de cataratas y cegueras y, aún más, cientos de miles de consumidores del mismo tuvieron secuelas como pérdidas de piel o cabello.

Se promovieron más de 1500 demandas en su época y en ellas se demostraron antecedentes como, por ejemplo, el hecho que el laboratorio supiera, antes que el producto fuera puesta en el mercado, que tenía la capacidad de producir esos trastornos, pues ya se habían revelado en las pruebas de rigor con animales. Más aún, se comprobó que algunos empleados del laboratorio modificaron informes experimentales que calificaban el medicamento de «muy peligroso». Esos informes falsos fueron presentados a la autoridad (Food and Drug Administration) con el fin de lograr la autorización para su venta.

En 1962 una treintena de abogados litigantes en contra de la farmacéutica se unieron para compartir experiencias, materiales y veredictos en forma voluntaria para trabajar en forma coordinada en los casos. Incluso llegaron a crear una escuela en la que le enseñaban a otros ligitantes cómo tratar sus casos.

Un juez federal condenó tanto a Richardson-Merrell como a sus científicos jefes porque sus acciones excedían la mera negligencia, y se aproximaban más al fraude. Además se culpó a la FDA por ser demasiado laxa en sus controles.

Compuesto químico

El compuesto activo del MER/29 es el triparanol o 2-(4-clorofenil)-1-[4-[2-(dietilamino)etoxi]fenil]-1-(4-metilfenil)etanol. MER/29 reduce drásticamente la biosíntesis del colesterol al disminuir la conversión de desmosterol a colesterol a través de la inhibición de la acción de la enzima desmosterol-Δ24-reductasa. Además reduce la conversión (isomerización) de esteroles insaturados de Δ8 a Δ7 por inhibición de la dehidrocolesterol Δ7 reductasa, la enzima final de la ruta biosintética. Esto conduce a la formación de una variedad de esteroles «aberrantes» Δ8 insaturados.

La administración de MER/29 produce una acumulación en el hígado y el suero de desmosterol y lleva a su acumulación en los tejidos de embriones.La concentración de demosterol en suero humano alcanzaba una meseta a las dos semanas de ingerir el compuesto, se mantenía mientras se continuara el suministro y desaparecía dentro de las dos semanas posteriores de su suspensión.

De acuerdo con una investigación de 1961, «rebaja las concentraciones de colesterol total en suero. Sin embargo, debido a la acumulación de demosterol, la respuesta en términos de colesterol total no es dramática.» Esta disminución del colesterol sérico era asociada con un posible efecto antianginoso (en 12 de 28 sujetos) y en la mejora de las respuestas electrocardiográficas (3 de 11 pacientes con angina de pecho). Sin embargo, años después se descubrió que el demosterol tomaba el lugar del colesterol en los depósitos de las placas de ateroesclerosis, haciendo inútil al MER/29 para el propósito original para el cual fue desarrollado. También es capaz de sustituir al colesterol en la retina tanto en forma funcional como anatómica. No obstante, no puede reemplazarlo en la transición de la fase G1 a S del ciclo celular, con lo cual, las células quedarían detenidas realizando la síntesis de proteínas y no podrían iniciar la replicación del ADN.

Efectos secundarios
Si bien algunos trabajos científicos publicados en las décadas de 1950 y 1960 indicaban que no tenía efectos secundarios importantes a la dosis máxima de 250mg/día, hay evidencias de que desde las primeras investigaciones se manifestaban síntomas variados de diferente entidad dependiendo de la dosis administrada.

Por ejemplo, con frecuencia se reportaban síntomas tales como náuseas, dolores de cabeza, erupciones cutáneas transitorias, caída del cabello y piel seca. En pacientes cuya dosis era mayor de 250 mg/día, el cabello podía caerse en forma más severa o cambiar de color, e incluso se informaron casos de ictiosis. En abril de 1961 se notificó de dos casos de reacciones cutáneas severas —blefaroconjuntivitis y meibomianitis—. Los dos pacientes desarrollaron cataratas en ambos ojos en agosto y diciembre de ese mismo año. En marzo y abril de 1962 se reportaron dos nuevos casos de cataratas. En ese momento el laboratorio decidió retirar del mercado el producto, si bien no fue suficiente para detener la aparición de nuevos casos. A partir de 1963 se impusieron restricciones médico-legales que desalentaron las publicaciones sobre el tema.

No existen cataratas que se puedan llamar «típicas» producidas por triparanol, por lo cual para poder diagnosticarlas en forma adecuada es menester realizar un análisis previo a fondo de la historia clínica de los pacientes. No obstante, la gran mayoría se encontraba en la parte subcapsular posterior del ojo.

Los ensayos en ratas mostraron que las cataratas inducidas por triparanol presentaban mayoritariamente dos tipos de lípidos: esteroles y fosfolípidos. El metabolismo de los lípidos es mucho más activo en la retina que en la parte vítrea del ojo, donde está prácticamente inactiva. El triparanol perturba este metabolismo, lo que explicaría la localización de las cataratas. También se comprobó que perturba el transportador catiónico en las cataratas, aunque se desconoce el mecanismo por el cual ocurre.

Además de la retina, la conversión natural de demosterol a colesterol se da en otros tejidos ectodérmicos superficiales, como la piel, lo que explicaría también los demás síntomas.

En experimentación de laboratorio se descubrió que el químico producía malformaciones en las extremidades de los huesos en fetos de rata expuestos a una sola dosis oral (150 a 200 mg/kg) dada a la hembra embarazada, lo que podría ser provocado por el bloqueo de las enzimas (tanto las reductasas como la isomerasa).

Antecedentes
A partir del descubrimiento, en 1939, de la relación entre la concentración en plasma de colesterol y el desarrollo de enfermedades cardiovasculares, comenzó un verdadero interés médico por conseguir fármacos con capacidad hipolipemiante.

El primer agente hipolipemiante en ser aislado fue un extracto tiroideo, eficiente para el tratamiento de pacientes hipo y eutiroideos, pero tuvo que ser suspendido porque presentaba importantes efectos secundarios. La abstención de comer alimentos ricos en grasa era por aquellos años la única alternativa. Sin embargo, en la década de 1950 se descubrió el efecto hipolipemiante del ácido nicotínico o niacina, que se sigue utilizando en medicina.

A esto le siguió la experimentación con cloruro férrico que, más allá de su eficiencia comprobada para precipitar sales biliares, producía graves efectos colaterales como cataratas, adelgazamiento y muerte de los animales de experimentación (en particular perros), por lo cual fue abandonado para continuar la búsqueda de un compuesto sin estos efectos indeseables.

En aquella época para que un medicamento pudiera ser comercializado en forma interestatal, la farmacéutica debía entregarle a la FDA informes completos con los resultados de las pruebas en animales que demostraran que era segura y no tenía efectos secundarios graves en humanos, si bien no necesariamente debía ser efectiva.

Investigación y venta
Los detalles exactos de las pruebas llevadas a cabo por Richardson-Merrell nunca se hicieron públicos. Sin embargo, a través de los juicios en su contra se pudieron establecer algunos hechos. Entre 1956 y 1959 los laboratorios de Merrel realizaron pruebas en ratas, perros y monos con el MER/29, a fin de determinar su eficacia, dosis, toxicidad en órganos y tejidos, además de convencer a algunos médicos de prescribir la droga a sus pacientes para poder experimentar con ellos.

Se demostró que la empresa envió una carta a la FDA para comunicarle que un mono había ganado peso cuando en verdad había perdido un cuarto de su peso corporal. Dos perros desarrollaron cataratas, pero el hecho apareció solo en el informe de autopsia; nunca fue reportado a la autoridad, como tampoco lo hicieron con un informe que les envió una compañía rival, luego que la droga estuviera en el mercado, indicando que el producto producía cataratas en animales.

Richardson-Merrell asesoró a sus vendedores para que al promoverla entre los médicos indicaran que era «enteramente segura» y libre de efectos secundarios. Además, ante quejas o consultas respecto a problemas o efectos secundarios, dijeran que no había antecedentes de daños o que eran causados por alguna otra droga.

La comercialización del MER/29 comenzó en abril de 1960. A mediados de 1961 la farmacéutica agregó al envase una advertencia por la pérdida de cabello, y en diciembre de ese año envió una carta a los médicos titulada «Querido doctor», aprobada por la FDA, para comunicarles los efectos secundarios del medicamento, justo cuando el número de usuarios alcanzaba los 400 000. En abril de 1962 por primera vez la FDA tuvo acceso a los datos experimentales verdaderos, constatando que había recibido información fraudulenta. Una semana después, Richardson-Merrell decidió retirar voluntariamente el producto del mercado, y el mes siguiente lo hizo la autoridad en forma definitiva, debido a que no era seguro para el público.

Véase también
 Talidomida

Notas

Referencias

Bibliografía consultada

Bibliografía adicional

Fármacos del sistema cardiovascular
Fármacos hipolipemiantes
Teratógenos


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Q: Does remounting after changes to overlayfs underlying filesystem (UB) necessarily restore consistency? The overlayfs documentation states that "if the underlying filesystem is changed, the behavior of the overlay is undefined, though it will not result in a crash or deadlock."
And, indeed, I've observed that when I make changes to the lowerdir in an overlay mount, strange stuff happens. However, if I remount afterwards, the problems seem to be fixed.
If I ignore the documentation's advice and modify the underlying filesystem online, will mount -oremount merged necessarily fix any issues caused by doing so?
(Yes, yes, I know the documentation says "changes to the underlying filesystems while part of a mounted overlay filesystem are not allowed" (emphasis mine), but I've heard otherwise.)

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This week's vote of no confidence has no constitutional basis.
We've had enough of top-down stitch-ups by the elite, whether corporate or more overtly political.
It is time for people power and now we have the technology to facilitate new participative processes.
Good points Rhea and I am voting for you as well as the rest of the NEC left slate.
Well said Rhea. Hope you have been notified by now that my North Shropshire CLP voted to support your NEC candidature on 17th June .
I've heard Rhea a number of times this past week doing phone-in interviews for LBC about the failed coup and she has come across really well in them and impressed me a lot. I really hope that young comrades like Rhea will now be the foundation for a rebuilt Labour Party in Scotland, particularly if she gets the place on the NEC she deserves.
As for Momentum, yes I agree with Rhea that it does have a transformative potential, however only if it can develop into an inclusive, vibrant democratic grouping itself. I know that there are fears of it being destabilised by some of the ultra-left external sects, but we have the numbers to make it work properly and combine a mobilising role with a theoretical one in developing socialist ideas for the 21st century.
Thanks Rhea. Please keep up the good work. I am a member of Momentum Plymouth. It's very important to have a movement which gives voice to the people who otherwise would not be heard due to the control of the main stream media by large corporations and politically biased organisations, not to mention the Murdoch press. Our values are the true values of the Labour Party, we are True Labour.
The likely result of any accomodation with the 170 is that membership of the Labour Party will plummit. If the plotters win and gain control over the party recognised members of Momentum will be expelled and Momentum proscribed. ( unless of course it does not become a bother to the party) The duty of Momentum is to keep those that voted Corbyn and a new style of politics together.
The problem is now that we all know that the coup plotters even if they cave in now will, if Jeremy leads the party to victory in the next general election, refuse to form a government under him and are more likely to bloc with the Tories to form a government of national unity and austerity. They have to go and if they cannot be de-selected then candidates should be stood against them who are pledged to help Corbyn form a government. What do Momentum plan to do on this front? Anything?
… they [Labour MPs] do not have the right to hold our party to ransom, they do not have the right to abandon the country when it is in desperate need of leadership, and they do not have the right to use bullying as a tactic to get their own way.
They do not indeed have those rights but it is now crystal clear that the majority intend to proceed on the assumption that the have those rights. That is the reality which we now have to deal with.
I would like to know more about how it is that so many centre and left MPs have been drawn into this. I have not yet seen an attempt to explain that from a left viewpoint. I would like to know if anyone has seen something on this.
Yes this is the really interesting and important aspect of it.
Obviously people who can be manipulated in theis way by the pied pipers of the Blairite and right are not entirely reliable employees but they do need to be worked on and allowed some partially face-saving way back.
I have no doubt that the main factor is simply the ostrich-headed desire to 'make it all stop' and avoid a split.
The coup plotters, in standard fashion, would like to make their own actions seem inevitable or reasonable or something hazily in between, and make it look as though Corbyn is responsible for the chaos and strife they have unleashed. They will have a tough job doing so.
When this is over, Corbyn will have proved his mettle and the plotters their venality. Whatever partial victory they may yet salvage looks like being distinctly Pyrrhic.
Yes, the Graeber piece does help to understand the left and centre MPs who have been drawn into this right-wing maelstrom. I hope that this experience will encourage at least some on the left to reject the "gut socialism" that all too many on the left think is a good basis for radical politics. It might be a starting point but if its adepts don't move beyond it then either they will follow a similar political path to the likes of Nye Bevan or Neil Kinnock or they will end up endlessly repeating the same simpistic notions and solutions.


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Bouncy the Balloon
We are proud to present "Bouncy the Balloon" – the first Android game to be released by us in full version.
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Home / 2022 / September / 23 / PMA Meeting Minutes 9/20/2022
23 September 2022 September 23, 2022 Kelly Farewell
Norwood PMA Meeting 9/20/2022
Norwood High School Library 7-8:30 p.m.
Attendees:
Kelly Farewell (note taker)
Karen and Mike Guarin
Jeff Kerr
Jane Yu
Eneida Shkurti
Wendy Keats
Sherri Munro
Siuyien Mathews
Steve Conant
Welcome & Introductions: President Kim Smith led, and all attendees introduced themselves, indicated their students' connections to the Fine Arts program, and described the positions they've held in connection to the music program. "Families make music together" being the new brand for PMA. Overall theme is that many of the roles are filled by parents of oldest students, many of whom are graduating. Need to cultivate parents of younger students to join and participate to keep PMA going.
Introduction to the new Director of Fine Arts, Jeff Kerr: Jeff Kerr shared his background, and expressed his gratitude for all that the PMA parents and association does across the district. He also shared his vision for the program, how the PMA can continue to support our students, and ideas about improving participation from elementary through high school. The PMA meetings will move throughout the district over the course of the academic year to attract new families. He is interested in a revamp of the website making it more current and useful including an overview of the program, and hopefully including a link to a district-wide calendar (which has already been shared with Fine Arts faculty). He has a background in technology and can also assist PMA with updates. May want to institute "QArt codes," with QR codes to artwork, to music, etc., and try to have field trips to live shows to inspire students. Perhaps have a "student takeover day" for social media to show a day in the life of a Fine Arts student in Norwood to generate student interest. Mrs. Moen submitted some grants before retiring, and with that 10 new instruments will be purchased (trumpet, flute, alto sax, clarinet).
Vice President's report: Karen Guarin reported on Norwood Day booth that the PMA hosted all day. Some merchandise sales ($260), many questions about piano lessons, but a steady stream of visitors. She also discussed having a PMA presence at NHS and Coakley open houses. We missed the opportunity to be present at the elementary school instrument distribution drive by event (roughly 300 families), but will make note of it for next year's board to have on their calendars.
Secretary's report: Kelly Farewell gave a broad overview of website updates that can be done, and the group reviewed the open PMA board roles that can be filled. Updates to be made and posted to the website this week.
Treasurer's report: Jane Yu gave a brief treasurer's report. The position is still in transition from the previous treasurer. We do receive funds from AmazonSmile donations. It's posted on PMA website, but not well publicized. Motion was approved to donate to $50 to Norwood Post Prom committee brochure. Motion was approved to purchase four 4×8 vinyl props for the marching band season for a total of $600. Motion was approved to spend up to $5,000 for new merchandise to sell at events since we frequently are asked for sizes we no longer have. Confirmed that outgoing treasurer Tracey Jones will file taxes.
President's report: Kim Smith is building an email distribution list. Also discussed the MICCA Marching Band home show taking place 10/16/22, including the building and grounds permit, temporary food permit, donation from Costco and/or BJs and student guides (sign up sheets to Steve Conant and choral teacher). Paul Campbell will handle power. Also setting up PMA alumni mentors to show upcoming PMA members how to perform these roles. Need to get the date on the calendar for Jazz Night, and start looking into equity and the cost of the event, venue, etc.
New business: Discussed the use of Squareup.com, Venmo, PayPal, and/or a QR code for donations and raffles since so many people no longer carry cash. For Home Show, Wendy Keats be in charge of 50/50 and will look into RallyUp as a non-cash option, possibly making it possible for the winner not to have to stay to end of show to be chosen as winner. Ed Ferris also has 3 SquareUp devices that can be used. Discussed social media presence and Jeff Kerr can assist with that once he is more familiar with what the district's policy is. Attendees completed their CORI forms and Jeff can submit on their behalf.


"It's the Worst Time to Make Money in Markets Since 1972," Bloomberg's Elena Popina writes.
Details: "Ned Davis Research puts markets into eight big asset classes — everything from bonds to U.S. and international stocks to commodities. And not a single one of them is on track to post a return this year of more than 5 percent, a phenomenon last observed in 1972."


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A number of Maldivian workers at a Villa Group resort have gone on strike over unpaid service allowances. The company is struggling after months of government imposed sanctions and has announced plans to sell off one of its luxury resorts to get back on track.
A Holiday Island official from the resort told The Maldives Independent that "some room boys have refused to work until they are paid."
The resort's operations are running smoothly despite the strike, he said.
The Maldives Independent was unable to contact the striking staff at the time of going to press.
The leader of Jumhooree Party (JP) Gasim Ibrahim owns Villa Group.
In May, the central bank froze the bank accounts of Gasim's Villa Shipping and Trading and subsidiary companies over US$90.4 million allegedly owed as unpaid rent and fines after the JP formed an alliance with the main opposition Maldivian Democratic Party (MDP) and launched an anti-government campaign in early February.
The freeze was removed on the back of JP's backing for government proposals in parliament and an agreement on a two-year payment plan. Villa Group maintains that it does not owe any unpaid taxes or fines.
Villa officials have said the claim had cost the company a US$80million loan. In May, it advised some 4,500 employees "who find it hard to work with us to rebuild the company again" to resign and promised to pay outstanding salaries at a later date.
Villa Hotels operate four luxury resorts in the Maldives. The parent company, Villa Group, operates businesses in shipping, import and export, retail, tourism, fishing, media, communications, transport and education.
Gasim is now planning to sell the Royal Island Resort.
"I will sell what I have to sell to pay debts and give what I owe," the business tycoon told Maldives Independent today.
He had previously told local media Avas.mv that he plans to sell the island for more than US$100million.
Gasim returned to the Maldives in early July after spending nearly three months overseas, during which he announced his retirement from politics once his term as MP for Maamigili ends in 2019.
While Gasim was abroad, he backed several government proposals, including a constitutional amendment that will disqualify him from running in the 2018 presidential election.
Villa won the tax authority's "Ran Laari" award last year as one of five companies that paid the highest amount to the state.
Several opposition politicians, including former defence minister Mohamed Nazim and former President Mohamed Nasheed, were arrested and sentenced to jail shortly after the formation of the JP-MDP alliance, sparking a six-month-long political crisis.
After months of street protests, historic mass anti-government demonstrations, and mounting diplomatic pressure, Nasheed was transferred to house arrest in late June after the government began talks with the opposition parties.
However, Adhaalath Party president Sheikh Imran Abdull remains under police custody until the conclusion of a trial on terrorism charges. Imran was charged with terrorism along with two JP leaders and accused of inciting violence at a mass rally on May 1.
The JP leaders, Ameen Ibrahim and Sobah Rasheed, subsequently fled the country and are living in self-imposed exile in the UK.
Government's seizure of Villa's resort properties unlawful, civil court rules
Gasim's Villa Shipping sued to recover MVR75 million
Related Topics:Gasim IbrahimJumhooree partyMIRARoyal Island ResortVilla
Housing ministry takes over more of city council's office space
Judicial watchdog tight-lipped on suspension of civil court judge
President ratifies new Maldives heritage law
Opposition leadership figures join Jumhooree Party
Tax authority collects MVR1.5bn in March
Transport minister at odds with party leader
Opposition declares support for 27 JP candidates
Future of Maldives ruling coalition thrown into doubt


text:
A Bunch Of Hooey From Michael Moore
Liberals spent the Golden Age of Sexual Harassment lecturing us that women never lie about such things, the seriousness of the charge demands it be taken seriously, and so forth. The beginning of the Lewinsky affair made it clear this perspective depends entirely on the politics of the accused. Anita Hill achieved sainthood by making wild charges against Clarence Thomas, but all of Bill Clinton's accusers were deranged, lying sluts who emerged from mobile homes in a shower of empty beer cans to begin their new careers as character assassins on the Republican payroll.
The latest demonstration of sexual assault politics comes from cinema propagandist Michael Moore, who is a big fan of accused rapist and WikiLeaks saboteur Julian Assange. In an interview with Keith Olbermann of MSNBC, after posting bail for his hacker hero, Moore dismissed the charges against Assange as "a bunch of hooey" about "a broken condom."
Explaining his decision to post bail for Assange on his website, Moore encouraged his slow-witted fans to "never, ever believe the 'official story.'" (He also makes a grimly hilarious assertion that WikiLeaks would have allowed "2 million Vietnamese to be alive today" by exposing the Gulf of Tonkin incident as a lie. That gigantic pile of dead bodies in Cambodia? Just ignore it, folks. It was a small price to pay for the workers' paradise, which Moore labors tirelessly to bring to these shores.)
Moore's callous dismissal of the Assange accusers recalls the contortions of the Hollywood Left to excuse Roman Polanski, who actually admitted his guilt, obliging his defenders to re-define either the nature or severity of his actions. This led Whoopi Goldberg to give us the famous "rape-rape" concept, as distinguished from the kinda-sorta no-harm-no-foul plain vanilla "rape." Rape-rape is apparently a crime liberal icons cannot be guilty of.
Feminist blogger Sady Doyle went nuclear after Moore's appearance on the Olbermann show, and created a Twitter hashtag, #MooreandMe, to batter him into submission. He eventually returned to MSNBC, the only network that could possibly take him seriously, to declare that "every woman who claims to have been sexually assaulted or raped has to be, must be, taken seriously. These charges have to be investigated to the fullest extent possible."
Congratulations are due to Doyle for twisting this loathsome man's arm behind his back, but that doesn't change what he said in the first place, or why he said it. The details of the allegations against Assange are widely spread across the Internet, where Michael Moore spends a great deal of his time. He deliberately discarded those details, and spoke of hooey and condoms, because the truth would interfere with his rapturous adoration of the WikiLeaks messiah. He only recanted because a prominent and energetic liberal forced him to. He never would have listened to such criticism from a class or political enemy, and if Assange had assaulted a couple of Young Republicans, he wouldn't have listened to Doyle either.
Perhaps she will spare a moment to reflect how many of her "progressive" friends are no different than Michael Moore, who is a living caricature of a fundamental, and very ugly, truth. Totalitarians demand a monopoly on the distribution of guilt, and truth. Anyone who claims you should "never, ever believe the official story" is demanding a level of faith thinking people never invest in any individual, especially a proven liar like Moore. You'll notice the biggest liars are the ones who demand that level of faith most stridently.
Terror Alert In Mumbai
Bombings in Rome
Texas AG launches investigation into Big Tech bias and discrimination against conservative voices
Gang of Ten Republicans Ignore Voters in Casting Self-Righteous Impeachment Vote
Media continues to replace inquiry with dogma on environmental issues


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Tag Archive for: AML
FINRA Tolerance for AML Compliance Failures Fading
June 2, 2016 /by Mitchell Atkins, CRCP
AML compliance failures are starting to get the "zero tolerance" message from FINRA. It recently announced its largest fine ever against two firms for AML compliance failures, including the suspension of the AML compliance officer. Mitch Atkins, a former FINRA official breaks down this action in a LinkedIn article. In reality, these sanctions are not too different in scope than that which was levied on Brown Brothers Harriman in 2014. The difference is there are two firms involved in this sanction. Also, the failures in the Brown Brothers case appear to be more limited to the area of low-priced securities and while that is an element of the recent action, it seems broader in scope as to the nature of the compliance failures.
At the recent FINRA Annual Conference in Washington, D.C., FINRA's head of Enforcement, Brad Bennett, indicated in his comments during a panel discussion that there were more enforcement cases to come in the AML compliance space. Bennett stated that FINRA noted a signficant number of red flags in the recent case, but he suggested that future cases may involve actual money laundering rather than just compliance failures. I suspect these cases will be as significant or more significant given the apparent escalation of sanctions of late.
AML Compliance Failures Don't Necessarily Mean AMLCOs will be Named
The good news is that Bennett reassured the attendees that the action against the AMLCO in this case was an exception and that FINRA is not out to get compliance officers. He insisted that FINRA carefully considers naming compliance officers and would rather not do it at all. FINRA has long stated that compliance officers who are doing their jobs and who take reasonable steps to address compliance issues will not be named in disciplinary actions. Bennett warned, however, that should senior executives ignore the calls of compliance officers for additional resources and compliance failures were the result of such decisions, FINRA would not hesitate to name them in an action.
Mitch Atkins is a consultant to broker-dealers, investment advisers and financial firms. He has over 23 years experience in the securities industry and is the founder and principal of FirstMark Regulatory Solutions based in Boca Raton, Florida.
https://firstmarksolutions.com/wp-content/uploads/2016/06/Fotolia_88191110_S.jpg 539 890 Mitchell Atkins, CRCP https://firstmarksolutions.com/wp-content/uploads/2016/06/FirstMark-logo1-preview-300x110.png Mitchell Atkins, CRCP2016-06-02 08:11:222016-06-02 08:11:22FINRA Tolerance for AML Compliance Failures Fading
FINRA Foundation Announces 2022 Military Spouse Fellows
SEC Charges Avraham Eisenberg with Manipulating Mango Markets' "Governance Token" to Steal $116 Million of Crypto Assets


I am experimenting with videos and having fun doing it !
I will offer tips, practices and personal insights, on various topic including leadership, vulnerability, and communication.
In this short video, I'll share 3 simple and easy tips for you to be able to say "No" over the holidays. As a frantic time of the year (November/December), we often find ourselves overwhelmed, stressed out and running out of time for all the things we agreed to do.
This video, is an opportunity to learn or re-learn ways to slow down and free time to enjoy yourself over the winter holidays!


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Finally good weather!!!
Grilled Road Kill - Welcome Back "The Walking Dead"
Quechos....pics.
UDS down at the beach
UDS Storage Question
Brisket is done
I need a little help gentlemen.
Tri-Tip, Jerk Lamb, and Cheese Stuffed Pork Chops.
• Steak & Risotto (very pr0nographic)
Valentines Day Thermapen sale
Phubar's Rack o' Lamb Pron
rainbow trout (pron)
Smoked salmon and ribs
This weekends comp practice ribs... pr0n
Tamale Pot size for Mini WSM???
the weekend in pictures.....
ABT japeleno question
First cook & pr0n from the SS-Two
Heresy! Crock Pot Ribs....
Soul Food - Chicken Noodle Soup on a cold day
Hassleback Potatoes?
Need Advice Quick
Too many or too big of chimney on smoker??
Muffaletta '12
Keeping track of your cooks?
Brinkman upright vertical smoker- any good?
2 Fav Burnt End Uses
Rib Rub "Issue", Help Please!
Thermapen Customer Service
First Uds build, Season and Fatties
Padawan's savoy cabbage wiht some pieces of pork
Something different - smoked chicken soup
Surf & Chateau Provence seasoned Turf
Anyone know where to get a good Packer Brisket in Central Virginia
Landarc GCS BBQ sauce-poking fun at SirPorks
My new baby! OLE HICKORY EL!!!
Weber wheel tool
Calling All Brethren
Pig Shooters question
Weber Smokey Jo Vs Go-anywhere grill
Pork Tenderloin coming up.with pics
Taco night! Filler up..... PrOn
Turkey Legs 101
UDS/WSM + Kettle cart design ideas - input wanted please
Just built my first UDS
Recipe: The Spud Dog (pic)
Cooking a Whole Hog
What are the MUST HAVE BGE Accessories?
Different rubs?
Lobsta Roll
Slaw...Slaw...Slaw
• So what's cooking for Valentines?
Brisket ...why cook the whole packer?
Buckboard Bacon - Team Effort - Pron
New beans for side
is this drum safe?
beef short ribs with PrOn
Some advice for a company lunch I'm putting on Friday
Preference: Bar-b-kettle vs older OTS w wood handles
Beef back rib score?
Thermapen Promo Code
I love my chick!
outdoor kitchen ideas
need a new dish for a work potluck
Novice collecting bits for smoker, help!
Honey Bees and Almonds
Custom vertical smoker... Help!
Remote Thermometers
Cleaning a CTO
Stuff a smoked turkey?
What are the advantages of an offset firebox?
Tri-Tip Cooked Liked A Big Hunk Of Beef On The Big Green Egg
My new toy! Yoder YS640
Fire box to cooker ratio question
Al's Valentine's Day ribeye & salmon dinner (pr0n heavy)...
Check out this cool home-built trailer / toy hauler...
Phubar's SmoStewed Mr.Ed Pron
New Lodge Dutch Oven
Smoking Guns rub
Can't decide on a smoker
The Biggest Steak I Ever Done Saw
Need Help With A Hot Sauce (Recipe?)
Containers for Pork Brines
WOW!!! Stoker WiFi Is Here!
Blue Cheese Linguine with Buffalo Walleye
Amazon score
Texas Pepper Jelly Secrets
Books for Me
• EPIC V-day Dinner Thread... (LONG & very pr0nographic)
Source for plastic spice/rub bottles and jars?
Smokehouse Fire
Ribs for 40 Cypress CA
$1.49/lb is this a good price?
Turkey Legs
Storage help
How to clean a ceramic smoker
you're my go-to authority
Ribeye Roast
Spare Ribs - Trimmed or Whole
smoker shelter
New Hottest Pepper on the Planet?
Grilled Stuffed Chicken Pron
Cover for my smoker
Valentine Memories (1xpr0n)
First smoker build,help
Yoder YS640 Capacity
Mmm, barky...
Phubar's Daisy Duck Breast Pron Pt.4
A new pepper is crowned the hottest in the world!
Stoker Blower Adapter Install Help on UDS
Black gloves (latex looking ones)
Cajun Brisket?
New England BBQ'ers - $0.99/lb Pork Shoulders at Hannaford
Too little smoke????
sexy pron
Gooey Butter Cake - ST Louis Tradition
WSM with Digi Q II questions?
Mixing commercial brisket injection ahead of time?
Got Spares at Costco for $1.99
De-evolution of BBQ
WSM Questions
When the wife asks for Bacon and Eggs for breakfast...
The Shed burned to the ground...
Temps In WSM - Big Concern
Help me pick my side dish for Saturday
Best thing to turn into smokers
Yoder pellet cookers
Getting creative
1st brisket done in my UDS
Dry Aging Beef...Wrapped vs Unwrapped??
Old school cook
When to sauce the ribs?
what a woman!
Auto-feed Injector
Why are primo grills/bge's better in cold weather?
Am i doomed for life.
Padawan's beef stew second time
Red Wine with BBQ suggestions
Judging School Lexington NC
**Messin' with Bigmista!!** Warning-Lots of Pics
Thermapen Give away on twitter
Pork loin goodness with pron
Go to grilled Swordfish receipes?
Hamtastic
My Ique 110 test with pron
North Carolina BBQ - A Redux
quick Q, billy ocean=??
Stirrin' up the ashes
A Couple Dirty New Yorkers.
Planning Some Freezer Meals
Help with a side dish??? Need some input!
Carolina BBQ
No steaks tonight!
Sad Note
Superior Smokers
1st Run with Stoker on UDS - Brisket
Tonight's Menu...Some Rib Sandys (Pron)
Diverse cook, inspired by the Brethren
Piri-Piri Chicken
Best thread for pastrami on the UDS?
Simply awesome...
Oakridge Santa Maria Tri Tip...Awesome stuff!
Pancetta - Botched?
Anyone Have Primo And BGE XL?
What temp before placing in fridge to serve next day?
3Eyez BBQ Class Review
smoking whole baby chickens
Joes BBQ Wood
Weber CL Find
Offset Smoker design - please explain
What should I cook today?
Pizza on a stick burner advice
Tri-Tip help, please
My Daughter Makes Me Waffles
BabyBack perfection
Ham Brine, salt free?
First Time Burnt Ends
Got reamed on beef back ribs...
Tryin to decide on a new smoker...
New pizza recipe try
Lump coal vs. Charcoal
Hispanic Style Beef Roast Ideas?
Pepperoni Pizza Fatty
Big thanks to Golden Toad BBQ
Doing rabbit for the first time, any suggestions?
Padawan and Phubar's RumpRoast with ParsnipPotatoPuree and Phunky Beets Pron
What are you paying for PRIME briskets?
Ok! Ideas for 100# of ground Angus!
Using Kosmos Private Reserve injection
Beer&Pomergranate Marinated Tri-Tip
Shrimp & Andouille Chowder! NOT Q!
Rocky Richmond
Grading Gripe, Beef Ribs, Santa Maria, Pron
Brownish grey meat on brisket
CL Score
Ok, I finally feel comfortable cooking spares to how I like them...
Chicken & sausage loaf
How to recondition a BGE
Little Black Egg: Grilling on the WSM
Hamtastic Cured Pork Butt a la Phrasty
Tamales 1st try....pics
Tonights dinner, pulled pork and some d*** good babybacks! w/pron of course!
Meat Glue
USA made Wireless Thermometers?
Charcoal taste on my chicken
Phubar's SmoStewed Mr.Ed Pron Pt.2
Practice, practice.... (PrOn to follow soon)
Review(pics) of 2 inch fire ring for large BGE
Storing a UDS
Smoking a Brisky 0830....
Stoke Master Questions...
First burn in the Backwoods Party
Stoker Question...
8 Lb Brisket Done in 4.5 hrs ??
Brilliant method of chopping wood
Smoke EZ conversion
Benefits of making your own rubs and sauces
It's 55 degrees here got the UDS running
What Grill
Blues Hog....Just Tried It....Not a Fan
Help with chicken quarters
Does anyone have reccomendations on used gas grills?
First smoke using a WSM - Pastrami
Temperature controller for 22.5 WSM?
Greek Koulouria Sesame Rings - with pics
Sputnik Metal Egg Reborn
triple meat loaf, my first casserole and a bottled beer.....
Pizza Pizza! Pr0n Included
Cooking a brisket like a burger
Today's Brisket w/ pr0n
Todays Smoke
Golden Toad Sample Pron!
Smoked a whole Chicken on My BGE Today
I want a bigger smoker
Smoked Pork Chop
Roast Beef w Portabella Sauce
Pork kabobs
recommend a "starter" stick burner
Rub Ingredients
Al's SM Cherry Beef Back Ribs...
Aluminum Frying Pan


text:
GLA NEWS
Dershowitz blasts lawsuit by Epstein accuser as a 'shakedown plot'
by admin | Dec 2, 2019 | Top Ten
In this image taken from video issued by the BBC, Virginia Roberts Giuffre speaks during an interview on the BBC Panorama program that will be aired on Monday Dec. 2, 2019. (BBC Panorama via AP)
OAN Newsroom
UPDATED 1:43 PM PT — Monday, December 2, 2019
Former Jeffrey Epstein attorney Alan Dershowitz has, again, denied a connection with a woman claiming to be one of Epstein's trafficking victims. Dershowitz appeared in federal court Monday as part of a federal defamation suit filed by Virginia Giuffre, who claims she was forced by Epstein to have sex with Dershowitz and others .
During the hearing, Guiffre's attorney said she would likely take advantage of a new law that allows victims of child sex abuse to sue their alleged perpetrators. Dershowitz, however, maintained his innocence and said her plan to file a new suit is a '"publicity stunt."
"She told the FBI she never met me, she told all of her best friends and her boyfriend she never met me," he stated. "Suddenly, she remembered having met me seven times only after she meets her lawyers as part of this shakedown plot."
Dershowitz claimed Guiffre wasn't underage when she was trafficked, adding, her story changes to fit the law.
"This is a woman has a long history of falsely accusing prominent men for money, and she has falsely accused me for money," he stated. "And that will be proved beyond any doubt at the trial."
Attorney Alan Dershowitz talks to the press outside federal court, in New York, Monday, Dec. 2, 2019. Dershowitz on Monday attended a court hearing in his ongoing legal battle with Virginia Roberts Giuffre, a woman who claims to have been pressured into having sex with Dershowitz by Jeffrey Epstein when she was 17. She and Dershowitz are suing each other, each claiming the other is lying. (AP Photo/Richard Drew)
Guiffre's attorney also called for communications between Dershowitz and Epstien during the hearing, saying they intend to use the privileged communications to prove Dershowitz had private motivations for securing Epstein a controversial plea deal in 2008. Dershowitz said he would be happy to released these communications, but it was up to Epstein's attorneys.
Dershowitz has also called to have a cassette tape returned to him, saying it contains statements from another attorney undermining Guiffre's claims. Guiffre's attorneys didn't comment on the hearing.
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2015 - 2019 All Rights Reserved. The information presented here is for general educational and enjoyment purposes only.


On the weekends of June 1-2 and June 8-9, 2013 some 79 volunteers turned out to census Elegant Trogons in all 5 border ranges in Southeastern Arizona where they are known to occur. Counters recorded all visual and audio observations in their territories from 6-11 a.m. By comparing times and locations of observations I was able to deduce the minimum number of Elegant Trogons present. Altogether 86 Elegant Trogons were documented: 49 males, 22 females, and 15 unknowns not assigned to gender because they were heard but not seen. All females were in proximity to males with whom they were assumed to be paired, yielding a total of 22 probable pairs. Eighty-six (86) represents the minimum known population of Elegant Trogons in the border mountains of Southeastern Arizona as of June 9, 2013.
These results probably do not fully account for all female trogons present. At this time of year many female trogons are incubating eggs or brooding chicks for most of the morning. Based the behaviors of male trogons during the census, as well as incidental observations just prior to the counts in the respective mountain areas, an additional 11 trogons that were neither seen nor heard by the counters were thought to be present. These birds that escaped detection during the actual census are shown in parentheses in the table below.
The areas selected for this count were canyons from which Elegant Trogons are historically known. It is important to note, however, that with only 79 volunteer counters, a few canyons where trogons are either known or are suspected to have occurred in all five mountains were not surveyed for Elegant Trogons this June. All of these canyons are thought to be peripheral areas where probably no more than 1 pair—or conceivably 2 pairs—could be present. In the majority of these canyons probably none are present. Obviously more volunteer counters would be desirable to improve coverage of potential Elegant Trogon habitat in the future.
Santa Rita Mountains. Conducting research for the US Forest Service, I personally estimated 8-12 birds were using Madera Canyon in the late 1970s and early 1980s, as well as 1 pair in Cave Canyon, 1 pair in Garden Canyon, and 2-3 pairs in Josephine Canyon. These results largely agree with those of Linnea S. Hall (unpublished dissertation, U. of Arizona, 1996), who also found Elegant Trogons in Temporal Gulch in 1993 and 1994, and using Big Casa Blanca Canyon in 1994 and 1995. This June count teams recorded 11 Elegant Trogons using Madera Canyon, as well as additional birds in Cave Canyon (1 pair) and Temporal Gulch (2 pairs). Although no trogons were detected in Josephine Canyon on the actual survey, 2 trogons were found there on 5/29/2013. It appears that Elegant Trogon populations in the Santa Rita Mountains are stable.
Patagonia Mountains. Hall surveyed for Elegant Trogons in 4 canyons in the Patagonia Mountains in 1994 and 1995 and found only 1 male. Several sources have reported trogons using the Patagonia Mountains since then (Matt Brown, pers. comm., Jennie MacFarland, pers. comm., and Helen Snyder, pers. comm.), but numbers for the mountain range as a whole were not known. Although no nests were discovered in the survey, having counters document 15 Elegant Trogons on June 9 this year may mean the Patagonia Mountains have become an important Arizona breeding area for the species.
Huachuca Mountains. On June 10, 1980 in a census similar to the one volunteers completed on June 1, 2013, counters found 33 Elegant Trogons in the Huachuca Mountains. In work spanning from mid-April to late June, Linnea Hall and 4-5 assistants recorded 37 trogons for the Huachuca Mountains in 1993. In 1994 she and her team found 76 trogons in this range, the greatest number ever recorded for a single mountain range within Arizona. This year the survey team documented 34 birds in the Huachuca Mountains, and—based on behaviors the counters observed—probably there were at least 38 Elegant Trogons present. Excluding 1994 when record numbers of birds were recorded by Hall, the population of Elegant Trogons in the Huachuca Mountains appears to be stable.
Chiricahua Mountains. In the Chiricahua Mountains where I conducted most of my Elegant Trogon research from 1977-1984, I found numbers in the S. Fork-Cave Creek Canyon complex were remarkably consistent. The low count of 20 adults was in 1979 and the high count of 23 adults occurred in 1978. Using the same methods, annual June S. Fork-Cave Creek trogon counts sponsored by the US Forest Service were conducted from 1991 through 2001. The peak number was 1994 when 30 volunteer observers found 22 trogons in the S. Fork-Cave Creek Canyon complex. The lowest number recorded was 1999 when 28 observers found just 12 adult Elegant Trogons. The lowest number ever found in the S. Fork-Cave Creek Canyon census was June 26, 2011 when only 7 trogons were detected. This was the same day the 223,000 Horseshoe II Fire was officially declared 100% contained. Eight (8) Elegant Trogons were found in this area in 2012, and this year 26 volunteers documented 6 trogons in the S. Fork-Cave Creek Canyon complex. Based on behaviors exhibited by the males and an observation 3 days earlier, it seems likely that 3 additional females were present—or 9 adult trogons altogether. Working in Rucker Canyon, a survey team discovered 3 other trogons, including a pair, but teams in 3 other Chiricahua canyons failed to find any. Therefore in 2013 the total number of known Elegant Trogons in the Chiricahua Mountains was 9, and there were probably 12 individuals altogether.
Directly through habitat destruction, or indirectly through watershed degradation, fuel reduction activities, actual fire suppression, or a combination of these and other factors, the 2011 Horseshoe Two Fire apparently continues to have a negative impact on Elegant Trogon populations in the S. Fork-Cave Creek Canyon complex of the Chiricahua Mountains. At present the S. Fork-Cave Creek area appears to be the only canyon system within its U.S. range where Elegant Trogons have suffered a clear and significant decline.


text:
Q: How to run Windows Script File in Windows service recovery I have written a script(.wsf) to trigger an Email when a particular service fails. For first,second and subsequent failure i have given run a program and added my .wsf file in that tab. Yet i am not getting Email alert. May i know what i should do to execute that.
Steps taken : ( But no result/didn't work)
1) In the run a program tab , gave the complete path of the script
2) Written a bat file and which inturn call that .wsf file
3)Gave the path of administrator cmd.exe path in run a program tab and gave the path of the script file in the command line parameters tab.
Note: I have executed this separately in cmd.exe and it worked by sending Email alert.
To make service fail i manually stopped it, restarted it yet notify didn't turned up. Please let me know what i should do further in executing the script from windows service recovery tab. I hereby added my script too.
<job>
<script language="VBScript">
Option Explicit
On Error Resume Next
Dim WshShell
set WshShell=CreateObject("WScript.Shell")
WshShell.run "cmd.exe"
WScript.Sleep 1000
WshShell.SendKeys "telnet smtp.sample.com 25"

WshShell.Sendkeys("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "EHLO sample.com"
WshShell.Sendkeys("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "MAIL FROM:alice@sample.com"
WshShell.SendKeys ("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "RCPT TO:bob@sample.com"
WshShell.SendKeys ("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "DATA"
WshShell.SendKeys ("{Enter}")

WScript.Sleep 1000
WshShell.SendKeys "Subject: Test Email"
WshShell.SendKeys ("{Enter}")
WshShell.SendKeys ("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "Body-Test Email executed by running script"
WshShell.SendKeys ("{Enter}")
WScript.Sleep 1000
WshShell.SendKeys "."
WshShell.SendKeys ("{Enter}")
WScript.Quit
</script>
</job>

A: Trying to automate a process with tools designed for desktop usage from a task executed from a system service and which runs in a limited session, .... if it works you have big luck.
There are a lot of problems involved in getting it working, and not sure if it will work on new versions of the system.
If a scripted telnet session is needed, your better option will be plink command line tool from putty package.
Or you can try with CDO
Set objEmail = CreateObject("CDO.Message")
objEmail.From = "alice@sample.com"
objEmail.To = "bob@sample.com"
objEmail.Subject = "Service is down"
objEmail.Textbody = "The service has failed"
objEmail.Configuration.Fields.Item("http://schemas.microsoft.com/cdo/configuration/sendusing") = 2
objEmail.Configuration.Fields.Item("http://schemas.microsoft.com/cdo/configuration/smtpserver") = "smtp.sample.com"
objEmail.Configuration.Fields.Item("http://schemas.microsoft.com/cdo/configuration/smtpserverport") = 25
objEmail.Configuration.Fields.Update
objEmail.Send


A natural, plant-based ginger essential oil flavouring.
Our essential oil flavourings are pressed from the plant or fruit and then purified. This process cleans the oils visually and increases their purity of flavour while adding tartness.
Each fruit or plant has been selected for its unique flavour characteristic.
Flavouring oils are natural products and offer excellent value for money and ease of use.
Dosage: 'To Taste', simply add a few drops of oil in chocolate, desserts, ganaches, marinades and sauces.


text:
Everything You Need To Know About Facebook Marketing
Over 2.7 billion people use Facebook every month, making it by far the most popular social media platform in the world.
With a vast audience that includes diverse demographics and a range of interests, the site has become a hub for marketing. Despite the world of opportunities that Facebook offers to businesses and organizations looking to advertise, many become frustrated due to the perceived complexity of the platform's marketing abilities. Fortunately, it is not difficult to learn the ins and outs of this advertising behemoth, it just takes a little work.
What Is Facebook Marketing
Facebook marketing is an all encompassing term that refers to all the ways that you can advertise and perform audience outreach by way of the site. This includes sectors such as Facebook Ads, Facebook Marketplace, Business Pages, and Facebook Groups. These unique options provide anyone, regardless of their budget or objective, to find a strategy that works for them.
Why Is Facebook Marketing Beneficial
Millions of businesses (around 90 million to be exact) are already successfully using Facebook in one form or another to expand their outreach to potential customers and clients. There are about 1.88 billion users who access the platform each day and 17% of them do so to connect with companies and organizations they are interested in. With these high rates of interaction, it is easy to develop connections with new audiences that can promote the generation of quality leads.
How To Start Facebook Marketing
The best way to begin Facebook marketing is by setting up an official Facebook page for your business. From here, you can have access to features such as the ads manager which allows you to easily track the success of your campaigns and make changes along the way. Following this, there are several things that need to be taken into account including…
Ad objectives: This gives you the opportunity to set goals for factors such as your brand awareness, reach, conversion rates, and lead generation.
Budgets/schedules: Facebook allows you to customize your budget on both a daily and monthly basis. Also, you can set schedules for your ads that put them out at the times that your audience is most likely to engage with them.
Ad platforms: This is where you decide where and how your ads appear on the platform. These include options such as what device type or operating system they will be targeted towards.
What Types Of Facebook Ads Are There
There are several different ways that your ad can be presented on the Facebook platform. These include forms like:
Carousel ads: Users scroll through a collection of photos that show products from different angles
Video ads: Videos that can be used for such things as showcasing products, boosting your brand identity, and providing customer testimonials
Image ads: Static, single picture ads that can be used to drive traffic to your site or business page.
What Makes A Great Facebook Ad
There are several general guidelines that you should follow when trying to cultivate a great Facebook ad or marketing campaign, such as:
Using high quality photos and videos for your advertisements and business page
Using A/B testing to figure out which ads are doing the best
Keep call to actions visible and engaging
Include your audience when appropriate to enhance a community feel
CLICK HERE FOR YOUR The 7-Day Guide To Making Money With Facebook Ebook (PDF)
FacebookFacebook AdsFacebook GroupsFacebook MarketingFacebook Marketplace


text:
package twofactor

import (
	"strings"
)

// Pad calculates the number of '='s to add to our encoded string
// to make base32.StdEncoding.DecodeString happy
func Pad(s string) string {
	if !strings.HasSuffix(s, "=") && len(s)%8 != 0 {
		for len(s)%8 != 0 {
			s += "="
		}
	}
	return s
}

redpajama_set_name: RedPajamaGithub


Avi joined Ben-Ami in 2005, became a certified patent attorney in 2007 and partner in 2010. He deals mainly with drafting and prosecution of patent application throughout the world in all fields of life science, including organic chemistry, biochemistry, peptides, biotechnology, pharmaceuticals, formulations, diagnostics, physical chemistry, nanotechnology, material science, alternative energy, and medical device, and drafts patentability and freedom-to-operate opinions. His professional experience in his previous activities enables him to achieve a solid understanding of the inventor's needs and the scientific basis for complex inventions.
Avi served many years in the IDF/Military Intelligence, first in the main intelligence collecting unit and then in the Production Division. In his final position as the Head of the Chemical and Biological Branch he was responsible, inter alia, for managing, directing and leading the whole communal intelligence research in the fields of Chemistry and Biology; integrating and processing complex and diverse scientific and intelligence information from a variety of sources and disciplines; analysis and assessment of R&D and production activities including engineering analysis of processes and systems; initiating, supervising and professionally coordinating various projects performed in laboratories of leading Israeli research institutes, in cooperation with the projects' leaders; and initiation and involvement in development of advanced methods for collecting and extracting intelligence information in the fields of Chemistry and Biology.


text:
MyShowdown lets you crowdsource answers to the biggest debate questions
By Jon Martindale	 May 24, 2017
MyShowdown.com is a new platform for discerning what the best of anything is. What's the best low-price digital camera? Who would be best to play a character in a new movie adaptation? Which is the best football team, really? These are all questions MyShowdown looks to answer, by crowdsourcing the answer.
Unlike a lot of social communities which focus on conversational interaction, MyShowdown distills the process down to questions and answers from the community, in the form of multiple-choice polling. Users are asked a question as part of a "showdown," and then given the option to vote on their preferred answers. You'll only find out the results after voting, though everyone can discuss them in attached comment sections.
Accounts are twinned with your Facebook or Twitter profile and you can follow along with certain showdown creators to keep up to date with their latest questions. Those same creators can embed showdowns in their own websites and blogs, making MyShowdown a simple platform for adding user interaction to news and blog posts.
Along with users creating their own questions for the wider community though, the editorial staff at MyShowdown will also submit their own from time to time, keeping an eye on trending topics and giving users a chance to weigh in on some of the most important topics of the day. While they won't always be serious, it could be a handy tool to gauge public interest in certain demographics.
Users can navigate through a range of categories to find showdowns that will interest them the most and there is a not-safe-for-work filter, so that families or individuals can keep clear of showdowns that may have more of an adult theme.
"With MyShowdown.com we are providing millennials with a platform to begin a conversation and let their peers develop the story with their own advice, opinions, and answers," said Eric Diamond, co-founder of MyShowdown.com. "It's a true open forum that allows them to reach their wider peer group and engage in direct communication."
Although recently launched, MyShowdown is already populated with a number of topics important and trivial, waiting for you to weigh in on.
The best Jackbox games
The best subreddits you should subscribe to in 2021
The best texting games for 2021
What is cloud gaming?
Meet the man on a controversial mission to preserve and digitize your brain
The best car-sharing apps for Android and iOS
The best firewalls for small businesses in 2021
How to recall an email in Outlook
What is a meme? Here's everything you need to know
Why do you see ads for stuff you've already bought?
Get ready, kids, these Santa trackers are about to fire up!
How to use Microsoft Teams
How to change your Yahoo password
What is Reddit?
These are the 10 most disliked videos on YouTube


text:
Q: Eloquent Laravel show Trying to get property 'code' of non-object I have 2 model created like below:
Employee.php
<?php
namespace App;
use Illuminate\Database\Eloquent\Model;

class Employee extends Model
{
    public function grades(){
        return $this->belongsTo(Grade::class);
    }
}

and also
Grade.php
<?php

namespace App;
use Illuminate\Database\Eloquent\Model;

class Grade extends Model
{
    public function employee(){
        return $this->hasMany(Employee::class);
    }
}

when I try to show code ane name of Grade in tinker like below
$a=App\Employee::find(15);<br>
$a->grades->code

it gives me error :

PHP Notice:  Trying to get property 'code' of non-object in Psy Shell code on line 1*

table employees:

table grades:

A: Change your grades() method in the Employee model to grade().
Eloquent uses the method name to determine the database column to use for the relationship. It would have also worked if you changed the column name to grades_id or if you optionally defined the column on the relationship like this:
public function grades()
{
    return $this->belongsTo(Grade::class, 'grade_id');
}

A: Please add with and try :
$a = App\Employee::with('grades')->find(15);


INCOME is money that people earn. Most people earn income by working. They receive income called wages and salaries. Some people earn income in the form of interest, rent, or business profits.
Example: Joe is a mechanic. He owns his own auto repair store and earns income (salary and profits) when he fixes cars.
Income is money that people earn. Most people earn income by working at jobs. They receive income in the form of wages or salaries. In fact, about three-fourths of all the income earned in the United States comes from wages or salaries, including fringe benefits. The other fourth of income earned in the United States goes to owners of capital resources (tools, equipment, buildings, machinery, etc.) in the form of rent, profit, and interest.
The income workers earn varies greatly from job to job, and even within jobs. Why is this? Students should understand that wages are determined by the forces of supply and demand in the market for productive resources (human, natural, capital). And the demand for workers is influenced primarily by the value of what they produce. In other words, highly productive workers who help a firm earn more profits will be in higher demand than less productive workers. This explains why some people, like sports stars, are so highly paid. Their services can result in huge profits for team owners.
So what does all this mean for your students? It means that they should consider carefully which jobs businesses will demand in the future. To increase their chance for higher incomes, it also means students should take steps to increase their productivity, thus making themselves more valuable to businesses. This acquiring of human capital usually happens through more education, training, and experience.
Invite a human resource person from a business to the class to discuss skills and qualities the business is looking for in employees. Make sure the class prepares questions to ask before the person comes.
The United States Bureau of Statistics has a comprehensive web site on the labor market. Have your students examine the wages and salaries of hundreds of occupations at www.bls.gov/oes/current/oes_nat.htm. A better site for your students to use is the Career One Stop (www.careeronestop.org). Click on "Other In-Demand Occupations" on the left column of the web site.
To find good employment, students should consider not only the demand for a particular type of job, but also their own skills and interests. Have each student create a Skills and Interest Profile. They should share and discuss this profile with other classmates.
Have students create a bulletin board using data from 1 above, especially Career Voyages. It could be entitled, "Hot Jobs for the Future" and list wages, projected growth rates, salaries, and education/skill requirements.


On average, employers receive more than 250 applications for a public job posting, yet only about four to six of them qualify for an interview – only 2 percent! That means that you need to find ways to stand out.
At Advance Financial, we have found that potential employees stand out most if they are "go-getters" – those who seek out challenges and solutions, who have big goals for themselves and their careers, and who take active steps to achieve them.
This is one of our favorite characteristics to have in an employee. We look for people who take on any task without being asked. From taking out the trash in the breakroom to helping a coworker with a major project, no task is too small to show us you're a dedicated member of the team. Don't wait for something to come your way, seek out opportunities to get involved and use your professional skills. Those who can demonstrate their independence but still work well with others are the best additions to our team.
Any potential employee should have a clear idea of where they want to go in their careers and what they need to do to get there. Logically speaking, you can't be a go-getter if you don't have anything to "go and get." Map out your career path by thinking of your end goal and then plotting out the steps that will lead you toward it. Those steps may include training and development, which we offer at all levels of our company to encourage our ambitious employees to keep that energy going. When those goals are more obvious to you, they'll become more obvious to others, including your employer.
You can't be proactive nor will your goals be fully achievable if you don't have confidence in yourself. Don't hesitate to put yourself out there and show what you can bring to the team. Confidence is especially key in customer service, which is one of our main facets because it enables people to successfully interact with others throughout the day. And confidence is usually tied to enthusiasm. By holding your head high and taking on new tasks or customers with a smile and a positive attitude, you'll show your coworkers and supervisors that you mean business.
To join the Advance Financial team, you need to put your best foot forward and show us that you share our value of dedication for the work that we do. Without this dedication, we wouldn't be where we are today: a leading financial services company helping millions of people across the nation take control of their finances. Make your passions known and work hard for them, just as we do, and you'll be a great fit with us.


I put my hand up for this one so I could spend some time working out what I think.
Two words - "Mark Driscoll" - but I'm sure you've seen/heard his dating sermon already.
ah, he is indeed a legend.
I've heard him do one of his Q&A via text message things on some issues related to dating a few weeks back, but haven't actually got to his actual sermon.
You should check out "I Gave Dating a Chance." It was kind of written in response to I Kissed Dating Goodbye.
Oh my gosh!! I log in to see how my blogging friends are going and I read this?!?! :-D I'm busy reading "I Kissed Dating Goodbye" for the 2nd time (cos I couldn't remember anything from the first time) and I'd love to hear what you think of it! It has really spoken to my heart and I was actually just praying this afternoon that i'd find someone who had read it to get a second opinion! I think it's really good.. awesome in fact, but the only people I have spoken to who know of the book don't speak too highly of it..


At Ernst-Reuter-Platz Berlin we found this beuatiful piece of art. Arranged by the most creative artist of our times: the city itself. The city proves its whole potential in strength and resistance against the predominant form of mobility in this master piece of modern art. Through a sneaky act of malice and destructionthe the artist brought this vehicle off track and to its knees. All the best to the driver at this point, but metaphorically spoken it is a magnificent showcase for the ongoing struggle between the city and it's arthrosis means of transportation. Espacially at this spot of the city there are 200 car accidents a year – thats one every second day. Powerfull city – weak mobility solution.


text:
The Clinton Campaign's New Math
Unless something truly monumental produces lopsided victories for Hillary Clinton in the upcoming primaries, her chances for the Democratic nomination rely on superdelegates overturning the will of Democratic voters. Knowing this, her campaign has regularly identified criteria upon which the superdelegates might choose Clinton over Obama, some of which directly reflect the voters' intent (pledged delegate count, popular vote) and some of which are essentially judgment calls (electability, readiness). The campaign's problem is that the former criteria currently favor Obama and the latter don't lend themselves to a slam dunk consensus. In fact, they have so far been rejected by the majority of Democratic voters, who think electability and readiness are either better found in Obama or are trumped by Obama's ability to usher in change. If superdelegates were to cite Clinton's electability and readiness in order to coronate a nominee, it could drive voters out of the party.
But the Clinton campaign has found a new angle: imaginary electoral college votes. It is sending surrogates out to push the idea that superdelegates should vote for the candidate who would have come out ahead if the primaries were awarding electoral college votes instead of delegates.
This has a veneer of legitimacy because the campaign can say, "In the fall, the president is chosen through the electoral college. If you want to know who would make the best nominee, look at the electoral vote math." In fact, Clinton communications guru Howard Wolfson said almost exactly this to the New York Times.
Now, is this spin? Of course it is. The Clinton campaign will and has spit out any criteria it can think of that shifts the media narrative in its direction. It is losing the pledged delegate count, it is losing the popular vote, and it has lost more states. But it is in front when it comes to this notion of electoral college votes because it has won more big states. "It is our belief that at the end of the day, superdelegates will need to take into account a variety of factors," said spokesman Phil Singer on a conference call on Monday. "And that includes which candidate is going to be best able to accumulate the requisite 270 electoral votes."
The problem here is that these fictitious electoral college results have little, if any, connection to the electoral college results in the fall. Clinton won California in the primary, giving her bucketloads of these imaginary electoral college votes. (Because of how the Democratic Party awards delegates, the delegate results were relatively even in California. Electoral college votes are winner-take-all.) The same happened in New York. But Obama will win California and New York in the fall if he is the nominee. He's a Democrat. Winning California and New York in presidential elections is what Democrats do.
And then there's the fact that the winner of a state's Democratic primary is not necessarily the best Democrat to win that state in the fall. Clinton won the Democratic primary in New Mexico, where Kerry lost to Bush by one percent in 2004. The Democrats may need Obama's ability to appeal to independents and Republicans to turn New Mexico blue in the fall.
The question is, how will the media cover the Clinton campaign's latest ploy? In a Politico article recently, Jim VandeHei and Mike Allen made the point that a hard look at the delegate count shows that Clinton has "virtually no chance of winning" the nomination. But the media has a couple reasons for pretending like it does:
One reason is fear of embarrassment. In its zeal to avoid predictive reporting of the sort that embarrassed journalists in New Hampshire, the media — including Politico — have tended to avoid zeroing in on the tough math Clinton faces…
One important, if subliminal, reason is self-interest. Reporters and editors love a close race — it's more fun and it's good for business.
The media are also enamored of the almost mystical ability of the Clintons to work their way out of tight jams, as they have done for 16 years at the national level. That explains why some reporters are inclined to believe the Clinton campaign when it talks about how she's going to win on the third ballot at the Democratic National Convention in August.
I would add another reason: many in the media hold to a twisted form of objectivity. Instead of taking a hard look at the facts and stating them plainly, it gives equal space to both sides' arguments and spin. I'm guilty of some of this myself.
So the media can either: (1) ignore the Clinton campaign's new math; (2) report the campaign's new math, but explain the fallacy behind it; or (3) report the campaign's new math and pretend like its just part of the back-and-forth of a dogfight campaign that either candidate can win. The first two are clearly superior to the third, but it is the third that keeps Clinton viable. The fact that her campaign has realized that content-hungry 24-hour news outlets will report most of their spin as long as they keep producing it demonstrates that though they might not win this nomination fight, they'll never be beat on the media management front.


Most of the prominent requirements for application servers derive from the operations space. Taking this into account the next Java EE platform specification will focus entirely on platform as a service (PaaS) and cloud operations. Looking at what we have today still leaves a couple of questions unanswered. The one I get asked quite a lot is: "How do you configure GlassFish to receive notifications/alerts/messages on important log entries?". Seems to be a good topic to blog about.
You basically have three options here. Either you choose to integrate some notification magic into your application logging or you go with the system logging or you go with the more classy monitoring approach. However the differences should be clear. By default GlassFish does not provide any third-party logging integration. Whatever logging way you go from a framework perspective you will end up logging application specific events. If you are looking for some kind of application server specific notifications you have to take the system logging or the monitoring road.
The easiest configuration I have ever done. GlassFish supports Unix Syslog. By checking the "Write to system log" box in the "Logger Settings" at your desired configuration you enable this feature. In fact this works like a charm but has a couple of drawbacks. Syslog is a protocol that allows a machine to send event notification messages across IP networks to event message collectors - also known as Syslog Servers or Syslog Daemons. It's a connection-less UDP based IP protocol. Some kind of broadcast. If you want to react upon ERRORS or other severity messages you have to use the facilities which come with your syslog server/daemon. This might be a more high sophisticated appliance (STRM, Log Manager) or a piece of software. Most notably the syslog format isn't encrypted in any way so you have to be careful about configuring this. Syslog-ng isn't supported as of latest 3.1.2. And some more hints if you are interested in how this is done. Have a look at com.sun.enterprise.server.logging.Syslog and SyslogHandler. You see that you can only send messages to localhost. No chance to configure that. You have to use syslog forwarding if you want that stuff to end up on another machine. Running on Windows requires to install one of the many open or closed software products. I tested http://www.thestarsoftware.com/syslogdaemonlite.html">Star SysLog Daemon Lite and was quite happy with the results.
One last note: If you are stumbling over older Google search results refering to something called "GlassFish Performance Advisor" .. that actually no longer exists. Hasn't been ported to 3.x branch.
In fact, GlassFish doesn't provide a special logging framework integration unlike WebLogic server does. So going this way you will lose the core GlassFish system logs and you can only focus on application specific logging.And that is where the integration actually happens. On an application level. Almost any recent frameworks (Log4J, LogBack) have a couple of providers for you to use out of the box. In terms of notifications email is still the simplest way to go. For that you have to look for the right appender (SMTP). Both LogBack ( SMTPAppender ) and Log4j ( SMTPAppender ) offer something here. Configuration is straight forward and only requires you to input some stuff about your SMTP infrastructure. Don't forget to set the right level of logging here. You are definitely not willing to have all DEBUG level messages send to your inbox.
Still thinking about the syslog thing? Both Log4j and LogBack can produce syslog messages with their SyslogAppenders ( log4j, logback). But all the above mentioned drawbacks also apply here. On top of that you will not be able to receive the GlassFish core log messsages with your syslog server. There might be very rare and special situations where this would be of any help.
One last thing to mention is the monitoring approach. A couple of monitoring suites can actually read your logfiles (keyword: logfile adapters) and you can configure your logging solution to react to certain pattern. While I don't consider that elegant it might be a stable solution to work with and I have seen this a lot in the wild. Another approach could be to use JMX or even the GlassFish admin REST interface to find out about the relevant metrics. But both don't provide access to the logging subsystem.