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Singularities A singularity is in general a point at which a given mathematical object is not defined.
Examples:
1/x has a singularity at x = 0 as it seems to reach infinity. |x| (Absolute) has a singularity at x = 0 since it is not differentiable at that point. √x (Square root) has a singularity at x = 0 since it doesnot admit a tangent there.">
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Singularities A singularity is in general a point at which a given mathematical object is not defined.
Examples:
1/x has a singularity at x = 0 as it seems to reach infinity. |x| (Absolute) has a singularity at x = 0 since it is not differentiable at that point. √x (Square root) has a singularity at x = 0 since it doesnot admit a tangent there."/>

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Singularities A singularity is in general a point at which a given mathematical object is not defined.
Examples:
1/x has a singularity at x = 0 as it seems to reach infinity. |x| (Absolute) has a singularity at x = 0 since it is not differentiable at that point. √x (Square root) has a singularity at x = 0 since it doesnot admit a tangent there." />
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              GSoC Week 06 - The One with Singularities

              <time datetime="2016-07-01T00:00:00+05:30">
                July 1, 2016
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              3-minute read

    GSoC

      Sympy

      •

      Python

This week I worked on the topic of singularities.

  Singularities

A singularity is in general a point at which a given mathematical object is not defined.

Examples:

1/x has a singularity at x = 0 as it seems to reach infinity.

|x| (Absolute) has a singularity at x = 0 since it is not differentiable at that point.

√x (Square root) has a singularity at x = 0 since it doesnot admit a tangent there.

In real analysis, singularities are either discontinuities or discontinuities of
the derivative (sometimes also discontinuities of higher order derivatives).

A removable singularity of a function is a point at which the function is undefined,
but it is possible to redefine the function at that point in such a way that the resulting
function is regular in a neighbourhood of that point.

For instance,

f(z) = sin(z)/z has a removable singularity at z = 0.

This singularity can be removed by defining f(0) := 1, which is the limit of f as z tends to 0.

In SymPy, we try to automatically simplify some of the expressions before passing it for
further processing.

For example,

x/x simplifies to 1.

(x-1)^2/(x-1) simplifies to x-1.

At times, this can lead to incorrect behaviour.
Suppose, we are interested to find the singularities ( and/or domain ) of the function f(x) = x/x.

In []: f = x/x
In []: singularities(f, x)
Out[]: S.EmptySet # no singularities
In []: continuous_domain(f, x, S.Reals) # finding the valid domain of f on the real line
Out[]: S.Reals # should be (-oo, 0) U (0, oo)

After some discussion about this issue of automatic simplification, we came to the
conclusion that removable singularities should be treated as part of the domain of the function.
This will help in justifying the behaviour of expressions which are automatically simplified.

So, I studied about how to classify a singularity as a removable one.
For this, we use the Reimann’s theorem:

Let f a function defined on the set D \{a}.
The point a is a removable discontinuity if there exists a neighborhood of a on which f is bounded.

Mathematically,

lim   (z -a)*f(z)

z->a+

I have implemented this theorem in the form of a function but I face certain issues with
the values returned by solveset due to check_domain function (which checks the bound of a
function at a particular value). This remains to be discussed in the meeting.

After Thoughts

I have lots to discuss with my mentors on these issues.

After merging the PR#11277, I think solve_decomposition method will be good to go.

    ©

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We are looking for a Program Analyst who has a broad range of skills and whose role would span the activities of the organization: our Loan Program, our Education and Advocacy Program and also Fundraising. The Program Analyst would have primary responsibility for data management, analysis and reporting; and for research and reporting. This person will report to the CFO and the CEO. The position could range from 25 – 40 hours per week, depending on the background and qualifications of the candidate.
Types of research and data: company data (micro loan clients, donors, investors); industry trends (microfinance, socially responsible investing); World Bank data; Microfinance Information eXchange (MIX); MFI websites and financial reports; foundation websites and financial reports.
Self-motivated and able to work virtually but also a team player who works well in a small and fast-paced environment.
We are planning to grow our business this year with the launch of our website and also our back end technology platform which will manage data and automate processes. This person should be well-suited to contribute to this transition.
Experience in microfinance or the nonprofit industry is desirable but not necessary. We would prefer to hire someone with the right skills and commitment and have them grow with the organization. Experience of detailed financial analysis is not a requirement but would be of interest.
Salary and benefits will be commensurate with skills and experience.
Please send your cover letter, resume, and references to jobs@capitalsisters.org. Please provide information that demonstrates the skills and experience you will bring to the position, including if possible those related to working in a virtual environment.
Hi there. I'm wondering if this position is still possibly open?
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Check out a new position with Friendship Bridge one of our Members are Colorado Microfinance Alliance. A great organization that is helping server women in Guatemala.
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Under the Diehard Brand trade paperback | Galaxy Press
Fiction Bibliography
Battlefield Earth
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Under the Diehard Brand trade paperback
Lee Thompson must step in to help his father regain control over gunslinging town troublemakers. But when he arrives, Lee finds that he may be forced to abandon the rule of law, leaving his father's reputation as sheriff hanging in the balance.
Under the Diehard Brand trade paperback quantity
Other Retailers Amazon Barnes & Noble Books-A-Million Google Play iBooks IndieBound Kobo
SKU: 701953 Categories: SGA Books, Stories from the Golden Age Books, Western Tags: Stories from the Golden Age Books, Trade Paperback
Eighteen-year-old Lee Thompson has a chip on his shoulder and a mission in his heart to save his dad, an aging sheriff who's lost control of his town.
Old Diehard's lost control of his town, and it seems every outcast and outlaw west of the Mississippi is on the prowl in Wolf River. Now Lee's come all the way from Texas to stand up for his father, a man who hasn't seen him since he was a boy and who doesn't know him from Adam.
Lee's plan is a dangerous one—mix in with the desperadoes and risk death at their hand Under the Diehard Brand. But sometimes, the only way to restore the rule of law is to break it.
Also includes the Western adventures, "Hoss Tamer," in which a circus horse trainer turned bronco buster has to figure a way to tame a gang of outlaws; and "The Ghost Town Gun-Ghost," the story of an old prospector who seems to have lost his wits; but is he crazy … or crazy like a fox?
"Rife with action and adventure and laced with melodramatic undertones." —Library Journal
Most of the Westerns published in the all-fiction magazines of the first half of the twentieth century were written by authors more familiar with the streets of New York than the cattle trails of Texas. L. Ron Hubbard bucked the trend, and in the process changed the face of the Western adventure. He grew up in a time and a place where the Old West, though fading, still lived. His unique knowledge of the frontier, of its ways and its people, made him an authentic voice of this unique American experience.
Stories from the Golden Age
Under the Diehard Brand Glossary
Stories from the Golden Age reflect the words and expressions used in the 1930s and 1940s, adding unique flavor and authenticity to the tales. While a character's speech may often reflect regional origins, it also can convey attitudes common in the day. So that readers can better grasp such cultural and historical terms, uncommon words or expressions of the era, the following glossary has been provided.
angoras: chaps (leather leggings the cowboy wears to protect his legs) made of goat hide with the hair left on.
appetite over tin cup: head over heels; bowled over.
batwings: long chaps (leather leggings the cowboy wears to protect his legs) with big flaps of leather. They usually fasten with rings and snaps.
Billy the Kid: (1859–1881) a nineteenth-century American frontier outlaw and gunman, reputed to have killed twenty-one men, one for each year of his life.
Bird Cage Opera: "Bird Cage Theater," also referred to as "The Bird Cage Opera House Saloon." This was a fancy way in the 1880s of describing a combination saloon, gambling hall and brothel.
brimstone: "fire-and-brimstone"; threatening punishment in the hereafter.
buckboard: an open four-wheeled horse-drawn carriage with the seat or seats mounted on a flexible board between the front and rear axles.
buffalo gun: .50-caliber Sharps rifle, also called the "Big Fifty," which weighed twelve pounds. Noted for its power and range, it was the almost unanimous choice among buffalo hunters. The drawbacks were the cost of ammunition and the fact that the rifle's accuracy was seriously affected by rapid fire (it had to be watered down constantly to keep from overheating).
bulldogging: throwing a calf or steer by seizing its horns and twisting its neck until the animal falls.
cat-eyed: said of a badman who has to be constantly watchful to keep from being "downed" by a rival. Most men of this type make it their business to sit with their backs to the wall, facing the door.
cayuse: used by the northern cowboy in referring to any horse. At first the term was used for the Western horse to set it apart from a horse brought overland from the East. Later the name was applied as a term of contempt to any scrubby, undersized horse. Named after the Cayuse Indian tribe.
century plant: a plant with grayish green leaves that takes ten to thirty years to mature and flowers just once before dying.
chinks: short leather chaps (leggings), usually fringed and stopping just below the knee, worn over the pants for protection.
chuck wagon: a mess wagon of the cow country. It is usually made by fitting, at the back end of an ordinary farm wagon, a large box that contains shelves and has a hinged lid fitted with legs that serves as a table when lowered. The chuck wagon is a cowboy's home on the range, where he keeps his bedroll and dry clothes, gets his food and has a warm fire.
Comanche: originally a part of the Shoshonean tribe, the Comanches emerged as a distinct group shortly before 1700. This coincided with their acquisition of the horse, which allowed them greater mobility in their search for better hunting grounds. Their original migration took them to southern plains extending from the Arkansas River to Central Texas. By the mid-1800s, they were supplying horses to French and American traders and settlers. Many of these horses were stolen and the Comanches earned a reputation as formidable horse and later cattle thieves.
cowpuncher: a hired hand who tends cattle and performs other duties on horseback.
cow town: a town at the end of the trail from which cattle were shipped; later applied to towns in the cattle country that depended upon the cowman and his trade for their existence.
crik: creek.
cuspidor: a large bowl, often of metal, serving as a receptacle for spit, especially from chewing tobacco, in wide use during the nineteenth and early twentieth centuries.
Digger Indians: a name for Indians of the Southwest, Great Basin (between the Rockies and Sierra Nevada) or Pacific Coast. Most of these Indians were Shoshones or Paiutes. They were often called Diggers due to their practice of digging for roots.
drew rein: from "draw in the reins," meaning to slow down or stop by exerting pressure on the reins.
drill: shoot.
dry-washing: extracting gold from dry gravel by use of a machine.
dust: to depart.
false-fronted: a façade falsifying the size, finish or importance of a building.
faro: a gambling game played with cards and popular in the American West of the nineteenth century. In faro, the players bet on the order in which the cards will be turned over by the dealer. The cards were kept in a dealing box to keep track of the play.
fastnesses: remote and secluded places; secure places, well protected by natural features.
Fifty Girls Fifty: a chorus line of girls performing synchronized routines such as the can-can where they wear costumes with long skirts, petticoats and black stockings. The main features of the dance are the lifting up and manipulation of the skirts and high kicking.
fleeced: having deprived one of money or belongings by fraud, hoax or the like; swindled.
forked: mounted.
forked leather: mounted a saddled horse.
.45 or Colt .45: a single-action, .45-caliber, six-shot cylinder revolver first manufactured in 1873 by the Colt Firearms Company, a company founded by American firearms inventor Samuel Colt (1814–1862). The Colt, also known as the Peacemaker, was reliable, inexpensive and due to its popularity with cowboys became the symbol of the Old West.
forty-five or .45: a six-shot, single-action, .45-caliber revolver.
forty-one or .41: Derringer .41-caliber short pistol. Named for the US gunsmith Henry Deringer (1786–1868), who designed it.
furrin': foreign.
G-men: government men; agents of the Federal Bureau of Investigation.
GN: Great Northern Railway, the tracks of which extended more than 1,700 miles from Minnesota to Washington state.
gold-chased revolvers: gold-engraved metal, as ornamentation on a gun.
greensticked: the incomplete fracture of a bone in which one side is broken while the other is bent.
hammer-headed: stubborn, mean-spirited (of a horse).
hazed: drove (as cattle or horses) from horseback.
heeled: armed with a gun.
Henry: the first rifle to use a cartridge with a metallic casing rather than the undependable, self-contained powder, ball and primer of previous rifles. It was named after B. Tyler Henry, who designed the rifle and the cartridge.
hide-out: a gun, usually a short-barreled gun that can be hidden upon one's person.
hitchrack: a fixed horizontal rail to which a horse can be fastened to prevent it from straying.
Hood River: a county in Oregon, extending from Mt. Hood north to the Columbia River.
Hopi Indians: a Pueblo Indian people of northeast Arizona noted for their craftsmanship in basketry, pottery, silverwork and weaving.
hoss: horse.
ladino: a wild, unmanageable ranch animal.
lariat: a long noosed rope used for catching horses, cattle, etc.; lasso.
larrup: to strike; to thrash.
lath: made with narrow strips of wood formed into lattice.
lineback: having a stripe down its back that is of a different color from the rest of its body.
livery stable: a stable that accommodates and looks after horses for their owners.
longhorn: a name given the early cattle of Texas because of the enormous spread of their horns that served for attack and defense. They were not only mean, but the slightest provocation, especially with a bull, would turn them into an aggressive and dangerous enemy. They had lanky bodies and long legs built for speed. A century or so of running wild had made the longhorns tough and hardy enough to withstand blizzards, droughts, dust storms and attacks by other animals and Indians. It took a good horse with a good rider to outrun a longhorn.
mow: haymow; the upper floor of a barn or stable used for storing hay.
Nevadas: Sierra Nevada mountain range of eastern California, extending between the Sacramento and San Joaquin valleys and the Nevada border.
owl-hoot: outlaw.
papooses: Native American infants or very young children.
poke: a small sack or bag, usually a crude leather pouch, in which a miner carried his gold dust and nuggets.
pole-axing: striking down.
Pole Star: North Star; a star that is vertical, or nearly so, to the North Pole. Because it always indicates due north for an observer anywhere on Earth, it is important for navigation.
puncher: a hired hand who tends cattle and performs other duties on horseback.
quirt: 1. to lash or flog with a riding whip. 2. a riding whip with a short handle and a braided leather lash.
rag-tailed: "ragtag and bobtail"; describing a group of persons regarded as the lowest class.
redeye: cheap, strong whiskey.
rowels: the small spiked revolving wheels on the ends of spurs, which are attached to the heels of a rider's boots and used to nudge a horse into going faster.
run-over boots: old boots where the heel is so unevenly worn on the outside that the back of the boot starts to lean to one side and does not sit straight above the heel.
scatter-gun: a cowboy's name for a shotgun.
Scheherazade: the female narrator of The Arabian Nights, who during one thousand and one adventurous nights saved her life by entertaining her husband, the king, with stories.
Sharps: any of several models of firearms devised by Christian Sharps and produced by the Sharps Rifle Company until 1881. The most popular Sharps were "Old Reliable," the cavalry carbine, and the heavy-caliber, single-shot buffalo-hunting rifle. Because of its low muzzle velocity, this gun was said to "fire today, kill tomorrow."
Sierras: Sierra Nevada mountain range of eastern California extending between the Sacramento and San Joaquin valleys and the Nevada border.
single-action Army: Colt Single Action Army (SAA); a single-action, .45-caliber revolver holding six rounds. It was first manufactured in 1873 by the Colt Firearms Company, the armory founded by Samuel Colt (1814–1862). Initially produced for the Army to incorporate the latest metallic-cartridge technology, civilian versions were also made available in .32-, .38-, .41- and .44-calibers, among many others. The SAA, also referred to simply as Colt or the Peacemaker, gained popularity throughout the West and has become known as the "cowboy's gun."
single jacks: short-handled hammers with a three- to four-pound head. They are used to punch holes in rock.
sombrero: a Mexican style of hat that was common in the Southwest. It had a high-curved wide brim, a long, loose chin strap and the crown was dented at the top. Like cowboy hats generally, it kept off the sun and rain, fended off the branches and served as a handy bucket or cup.
spittoon: a container for spitting into.
Stetson: as the most popular broad-brimmed hat in the West, it became the generic name for hat. John B. Stetson was a master hat maker and founder of the company that has been making Stetsons since 1865. Not only can the Stetson stand up to a terrific amount of beating, the cowboy's hat has more different uses than any other garment he wears. It keeps the sun out of the eyes and off the neck; it serves as an umbrella; it makes a great fan, which sometimes is needed when building a fire or shunting cattle about; the brim serves as a cup to water oneself, or as a bucket to water the horse or put out the fire.
tapaderos: heavy leather around the front of stirrups to protect the rider's foot.
trail herd: a herd of cattle driven along a trail, especially from their home range to market.
truck: miscellaneous items.
varmints: those people who are obnoxious or make trouble.
wet stock: stolen cattle; cattle stolen from Mexico into Texas were taken across the Rio Grande River, and these were called "wet stock."
whang leather: tough leather adapted for strings, thongs, belt-lacing, etc., commonly made from calf hide.
whup into shape: "whip into shape"; to bring forcefully to a desired state or condition.
Winchester: an early family of repeating rifles; a single-barreled rifle containing multiple rounds of ammunition. Manufactured by the Winchester Repeating Arms Company, it was widely used in the US during the latter half of the nineteenth century. The 1873 model is often called "the gun that won the West" for its immense popularity at that time, as well as its use in fictional Westerns.
wrangler: a cowboy who takes care of the saddle horses.
yucca: any plant belonging or native to the warmer regions of the US, having pointed, usually rigid, sword-shaped leaves and clusters of white, waxy flowers.
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The company's program, Amazon Smile (named in reference to the iconic swooping shape on its boxes), lets consumers designate a 501(c)(3) charitable organization to receive 0.5% of the order price when the purchase was made through the smile.amazon.com website. While still using their same Amazon accounts–including any registries or wish lists they may have created–customers who access the site through a browser (not through an e-reader or Kindle app) can find products that are designated as eligible for the donation.
Of the nearly one million organizations that are already eligible to receive these no-consumer-cost donations, several are related to authorship and the book industry, including World Book Night, The Office of Letters and Light (NaNoWriMo), and Books for Africa, along with a host of other recognized non-profit charities related to furthering literacy, education, and writing. Consumers can change their charitable recipients at any time, essentially letting them designate a different charity each month, if they desired.
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So you feel good contributing to charity whilst they feel good taking your money and taking your freedoms. Right.


Strangest place you've seen the Boston spaceship logo? There have been some pretty unusual body parts it's shown up on. It usually looks pretty good, though, I have to say.
Were there bands you welcomed comparisons to? There were a few that I was flattered by, but I did think Boston was unique, in that it was strictly my vision of music. Just to step back a minute: When I created the songs and the sound that would turn into Boston back in 1974, '75, I'd basically given up on any chance of having a career in music. This was my last shot, and it was music exactly the way I wanted to hear it. Brad Delp came in to add vocals, which he did in spectacular style. But the music that ended up being signed by Epic Records in 1976 was music the way I wanted to hear it, and I didn't think there would necessarily be 10 other people in the universe who wanted to hear it. I didn't expect it to sell any records. In fact, I went back to work at Polaroid as soon as I finished making that record. So the whole experience has been one of shock.
You're the most meticulous and exacting rock band, but you made it look so easy. How? I drive myself crazy. It's like freestyle skating. The objective is to do things that are impossible and make it look like you're not breaking a sweat. It's the same approach with my music. It's friggin' impossible to play. So we rehearse and make sure we cover all the things that people expect to hear and then add some new stuff they haven't heard. It's really demanding. Backstage, there's no partying or people talking or hanging out. Everybody is warming up, going through these musical calisthenics so they can go onstage and make it look easy.
Do you prefer creating an album or performing live? Performing live is instant gratification and an incredible kick. It always was the motivating reason for writing songs and recording music. I never got into music because I wanted to be sequestered alone in a studio. My goal was to be a performing musician. Not a rock star. Just a guy in a band.
One concert or gig that stands out to you as the best? After doing it for 40 years there were so many, but I'd say maybe it was a toss-up between the Worcester Centrum, where we were the house band for 11 days back in 1987, or the Quebec City festival we played in 2015. I swear the entire city was there.
Do you prefer playing huge stadiums or clubs? Stadiums are too big. We've played a bunch of them. You're so far away, and the echo's so long, you're listening to the song you played just before. I have to say small arenas are pretty good places to play these days. I kinda rate things by what gives the best sound for the audience. The whole objective is to deliver the absolute primo experience of listening to music, and so I like those small arenas. Even if the acoustics aren't that great, the size creates a good ambiance. And again, I'd come back to the Worcester Centrum as one of my favorite places.
So do you still play classical piano? Only when nobody's listening. I've gotten really bad at it now.
How do you feel that your classical training informed your music? First of all, I got that ingrained muscle memory that makes it so easy for me to play keyboards. In comparison, I didn't start playing guitar until I was 20. I can not touch a keyboard for six months and step up to it and play it without even warming up. Guitar? It takes me 30 minutes just to be able to put a few notes together without sounding like a beginner. The other thing is that as a kid, I would listen to a lot of classical music. I'd blast Beethoven or Rachmaninoff. So I have all this classical music in my mind and was always heavily influenced by it when creating a melody.
Are you still a tinkerer? Right now, I'm sitting in my favorite spot: on the floor of what I'll grandiosely call my recreation room/laboratory. What it really is is a huge pile of junk. I have crap all over the place. I'm staring at the interior of an Echoplex that's been very resistant to me trying to solve a problem with the output level.
Are you the only rock icon with two degrees from MIT? I don't know of any others. But MIT was full of really talented musical people. There were some amazing musicians there. The talent there is phenomenal.
What do you think is the current state of rock 'n' roll? Really abysmal. I'm not impressed. It's taken a dramatic downturn and I won't go into all the reasons, but it can be traced primarily to the invention of very poor digital distribution. Here's an observation you didn't ask for: When I was in school, college kids were at the forefront of super high-quality sound. They were buying kits and building really great equipment. Everyone was obsessed with really excellent audio quality. Within the last 10 years, college kids embraced the most hideous-sounding means of audio distribution, MP3 files. I wish I'd never heard the term. Combined with the internet, I think it actually damaged people's ability to enjoy music.
Can you name three current bands you listen to and respect? That's presupposing I can name three current bands.
Beatles or Stones? Neither one. I was not in the mod category. I was on the edgier side. I liked the Kinks. The Yardbirds. The Animals. Steppenwolf. The Stones wrote some great songs, and I respect Mick Jagger. He's a very smart guy, but that's about it.
Person you want to collaborate with? There are many, but I'm so hard to work with, I wouldn't even try it.
Weirdest fan encounter? That would be too scary to relay over the phone. Of course, after 40 years, there have been a few. But on the other side of that coin, there have been some incredible stories. People who decided to go back to school or into rehab because of something I wrote.
Favorite use of a Boston song in a soundtrack? I enjoy them all, and I hate to say it, but I think it was Madagascar 2 [laughs].
Where do you keep all the platinum records and all that stuff? Primarily in the bathroom on the first floor.
Do you think there should be a mandatory retirement age for rock bands? Yeah, and I passed it like 10 years ago.
The last time I saw the Stones, I was like, "This show should be sponsored by Depends and denture grip." It's true. [Laughs] But I'm on a mission to do two things at my age: mount a kickass tour and land a double toe-loop.


"No one dares to imagine what it's like to be poor" a sad truth stated by Kenneth Douley, "because everybody is afraid to ask what's it like to be hungry, to not eat for three days, and be 3 months late in your rent payments. No ... no one dares."
The 54-year-old millionaire has long been helping people struggling to get their life in order, for he too, was once very poor due to his drug addiction.
Back then, Kenneth was a mathematics professor who lost his job and struggled to find something new, and people--including his former students and colleagues--tried their best to stay away from him.
He also went to different diners, begging for work and even food that was being thrown away. Still, people would tell him to go away. According to him, there was even one bar owner (a dad of a former student of his) that often tells him to "f*ck off".
At the beginning of 2013, finding himself homeless and having only a handwritten sign that reads "will do your calculus for chicken fingers", Kenneth Douley stood at a busy street at Montreal while feeling cold and hopeless.
"Being a broke and a homeless addict, standing in the middle of the street ... even my family severed all connections with me," Douley mentioned in an interview.
Kenneth Douley was desperately trying to win back his life after it was destroyed by drugs and alcohol. But he had not a single clue where to start. He remembers holding a sign describing his talents near a highway in Montreal, Canada.
Kenneth's dream of quitting street life and coming back to doing what he loves finally came true when a former student posted a video of him solving an impossible problem that other professors had trouble with.
In just three days, Douley went viral. He got a haircut, a shave and offers for work came, including being an executive assistant at a the gaming company that created Flappy Bird.
Now, the mathematical genius has another dream: to thank the homeless community who was there for him and even once saved his life.
Because according to Kenneth, it's easy to walk by the homeless and completely ignore them. But he made sure Canadians reflect more on ignoring the less fortunate. He decided to do something that caught everybody off guard.
For normal people like most of us, we go through life living from paycheck to paycheck, giving every bit of hustle to catch up on our never ending bills. Then there's the unexpected, a crisis that happens every time we thought we're a little bit safer financially. So how can someone who used to be homeless give away $50,000,000 so easily to people who society has already labeled as failures?
This guy have extended his generosity to more than one troubled person. In fact, he is generous to everyone.
Click here to grab one of these Feather Quill Calligraphy Set - Black for yourself!


The notion of war has been accompanying humanity from its very inception, intrinsically linked to violence, destruction, and sensationalism. The concept of warfare in the 21st century has shifted from the traditional "frontal" approach to the so-called "network warfare". The highly educated, tolerant and sensitive Western mind shuns away war (and conflict) just like it shuns away death, preferring to have it in a way that is mediated, to avoid the direct (body) experience of it.
As a result, the effects of warfare on the body itself are often compartmentalized to the kind of imagery that is merely shocking and sensational. Warfare is then (mis)understood as a kind of violent and destructive exercise only. The focus is mainly on the devastating results, excluding the actual practice and physical processes through which war shapes the human body society.
We propose to approach war from a different perspective. To study the physical, psychological, spiritual and political implications of war as a physical practice on the human body.
Warfare as practice of non-destruction.
Warfare as study of natural dynamics.
In order to do that, we will utilise the Russian military martial art Systema, as well as various training techniques used in warfare around the world.Systema, as a physical practice, has all of those principles embedded on the level of movement. Starting from connecting to the natural rhythms of the body, it is based on oscillation and redirection as the two main dynamical elements of combat .
Our intention is bring the notion of war back to its origin, towards the natural processes of non-destruction and adaptability, to transform the practice of war into the practice of dance, and to introduce dance into war.


Ionic is an open-source SDK for hybrid mobile app development, and an excellent tool for developing cross-platform applications. Our integration allows you to track crashes from your Ionic application - giving you detailed insight into your critical issues.
To enable your Ionic application to work with BugSplat crash reporting, view our Angular doc.


Abstract: Plan of Lot 34 (No.89). The property of Sir Graham Montgomery & Brothers. Shows names of residents and acreage, bodies of water such as rivers, and bays, roads, and a nautical compass.
1 map: col.; 63.5 x 126 cm.
Paper map on cloth backing. The paper map is cracked and peeling off of the backing. Some pieces are missing. The map has been taped. Ink has faded.
Plan of Lot 34 (No.89). The property of Sir Graham Montgomery & Brothers. Shows names of residents and acreage, bodies of water such as rivers, and bays, roads, and a nautical compass.
description Plan of Lot 34 (No.89). The property of Sir Graham Montgomery & Brothers. Shows names of residents and acreage, bodies of water such as rivers, and bays, roads, and a nautical compass.
format 1 map: col.; 63.5 x 126 cm.


For sauce, combine sour cream, basil, chives, ½ teaspoon salt, and the ground pepper in a food processor or blender. Cover and process or blend until nearly smooth. Cover and store in the refrigerator until ready to serve.
For kebabs, thaw shrimp, if frozen. Peel and devein the shrimp, leaving tails intact. Rinse the shrimp; pat dry. Thread the shrimp and zucchini alternately on six long metal skewers, leaving about ¼ inch between pieces. Combine olive oil, orange (or lime) peel, orange (or lime) juice, the remaining ¼ teaspoon salt, and the cayenne pepper in a small bowl; brush evenly on the shrimp and zucchini.
Arrange shredded greens on a serving platter. Top with the shrimp and zucchini; serve with the reserved sauce.


Could not be prouder of my little black lab! Performance Gold Lifetime Achievement Award in USDAA! The journey has been amazing! Good girl Crash! She is now PDCH Silver, Performance Lifetime Achievement Gold Kerrybrook's Collision Course PSCH Platinum, PJCH Platinum, PGCH Platinum, PKCH Platinum, PRCH Gold, PTM Silver. Happened on her 7th Birthday. Cool!


One thing I noticed about this year is that it went fast as hell once the b.s was removed from my life. I can't believe we are only a week away from Christmas. I'm excited about 2012 because a lot of cool things will be launching. COFFEA magazine will relaunch bigger and bolder, my single "Wouldn't Believe" will drop and a lot more special surprise I have planed for the year.
One very important thing I learned this year was to never hold yourself back. I have always heard the term but never grasped what it really means. Sometimes our choices are the only things that hold us back. Having enough love for yourself to push beyond comfort zone isn't always easy.
In 2012 I will travel like never before. I have a fear of planes but I have a passion for new scenery so it's time to go. I will be in NYC January ATL February St Louis March and for my birthday Bahamas in May. Sounds great doesn't it. I'm on two tours next year COFFEA Magazine tour and Grind In Progress /NFL Blitz tour.
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Receive accredited training with National Training Organisation – We provide an extensive range of qualifications to suit your next career move. From Certificate II to IV level we offer nationally recognised qualifications to help you grow to that next promotion or career move.
Our Fee for Service (FFS) qualifications are delivered flexibly, allowing the participant to choose the delivery model that best suits them. With options for class-based workshops, workbook and portfolio submissions, or a combination of both, NTO can provide the best training solution for you and your organisation.
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Your labs are absolutely beautiful. My labs get to roam free and love it also. I would not have dogs if I had to keep them chained up.
Mine love the water also and have brooks around for them to enjoy almost all year round.


Integrated Science and Technology, B.S.
While completing the ISAT courses, the student will also pursue the university's general education curriculum that is required of all students and is a cornerstone of the education received by every student. The required ISAT courses are listed below. A total of 120 credit hours are required for graduation.
In addition, a grade equal to or higher than "C-" is required for ISAT 151 , ISAT 152 , and ISAT 251 .
The Bachelor of Science degree in integrated science and technology produces a graduate broadly acquainted with basic science, technology and social science. All students pursue a common program through their sophomore year that provides a foundation of science and an introduction to its technology applications. Studies are integrated and include mathematics, statistics, physics, chemistry, biology, knowledge-based systems, internet networking and security, environmental science, modern production, energy, and the role of science and technology in society. During their junior and senior years, all students pursue deeper study of strategically significant areas that include applied biotechnology, energy, environmental studies, production systems, information and knowledge management, and telecommunications, networking and security. Each student selects a concentration in any of these areas and pursues additional study in the concentration culminating in a senior project. Students rely heavily upon the computer as a problem-solving tool throughout the curriculum, work in teams extensively and engage in laboratory experiences in the requisite sciences.
This sequence of five courses engages students in the practice of science, both to motivate and to provide understanding of science and technology in the context of important current social issues. Current areas from which issues are selected are living systems, the environment, modern production, internet networking and security, and energy.
Students complete 19-21 credit hours of instruction in strategic sectors during their junior year. The strategic sectors, developed from national critical technologies lists, represent areas of current strategic importance in the world economy. The sectors are applied biotechnology, energy, environment, production systems, information/knowledge management and telecommunications, networking, and security.
Students also have the option to tailor their area of concentration with the help of their adviser and the approval of the ISAT program director.
This is the capstone experience of the senior year. Working as part of a team of students and cross disciplinary faculty, seniors will propose, develop, manage, analyze and report on a project that addresses a real-world problem.
Students majoring in ISAT desiring to prepare for higher education in health careers (dentistry, optometry, medicine, pharmacy, physical therapy, veterinary) may waive some required ISAT courses if they take equivalent courses required by the pre-health programs.
These equivalencies are not generally granted outside of a pre-health preparation program. Students who begin a preparation but do not finish it may be able to have some of the courses waived. Contact Paul Henriksen, Coordinator for Students, for more information.


text:
Frasnay-Reugny is een gemeente in het Franse departement Nièvre (regio Bourgogne-Franche-Comté) en telt 71 inwoners (2009). De plaats maakt deel uit van het arrondissement Nevers.

Geografie
De oppervlakte van Frasnay-Reugny bedraagt dus 14,3 km², de bevolkingsdichtheid is 5,2 inwoners per km².

Demografie
Onderstaande figuur toont het verloop van het inwonertal (bron: INSEE-tellingen).

Externe links

Gemeente in Nièvre

redpajama_set_name: RedPajamaWikipedia


I'm not exactly a fan of lawyer/muckraker/journalist Glenn Greenwald, but I'm getting there. Greenwald certainly has an ideological agenda, and it informs both his choice of topics and the slant of his reporting. However, in an age where the mainstream journalism establishment has made the tragic decision to be largely a propaganda organization for its one favored political party, and has willfully misinformed the American public in pursuit of that party's interests, primarily power, Greenwald stands out for his non-partisan approach, his consistent standards, his integrity, and most of all of late, his refusal to participate in counter-factual condemnations of President Trump for conduct that the news media has either shrugged away or tolerated in the past from other Presidents.
Greewald's latest broadside against the hypocrisy comes in gloriously unrestrained The Intercept piece about the attacks on President Trump for his attitude toward the , Trump's Amoral Saudi Statement Is a Pure Expression of Decades-Old "U.S. Values" and Foreign Policy Orthodoxies.
The question of how far the U.S. should go in pursuing its own interests while excusing unethical or immoral acts by foreign governments is an enduring one the stretches at least back to the United States alliance with Stalin in World War II. Outside of the fact that [ the Khashoggi murder] involves a journalist, however, the Trump "guide," even stated in deliberately pejorative terms, seems to me to vary not one bit from the standards used by previous administrations, including the Obama Administration. China…Cuba…Iran…and yes, the Saudis, who have overseen state-sanctioned brutality and human rights outrages affecting whole classes of people, not just one journalist, for a long as anyone can remember.
Trump's "new blueprint," it seems to me, varies from the old blueprint not one bit. Whether the old blue-print is necessary or defensive is another issue.
None of this recent, ugly history…justifies what Trump did on Tuesday. But what it does do is give the lie to the flamboyant claims that Trump has somehow vandalized and degraded U.S. values and U.S. foreign policy rather than what he actually did: upheld their core tenets and explained them to the public with great candor and clarity.
This episode also exposes one of the great scams of the Trump era. The very same people who have devoted their careers to supporting despotism, empowering tyranny, cheering on atrocities, and justifying U.S. imperialism are masquerading as the exact opposite of what they are in order to pave their path back to power where they can continue to pursue all of the destructive and amoral policies they now so grotesquely pretend to oppose.
Anyone who objects to exposure of this deceit – anyone who invokes empty clichés such as "whataboutism" or "hypocrisy is the tribute vice pays to virtue" in order to enable this scam to go undetected – has no business staking moral claim to any values of truth or freedom. People who demand that this deceit go unnoticed are revealing themselves as what they are: purely situational opponents of tyranny and murder who pretend to hold such values only when doing so undermines their domestic political opponents and enables their political allies to be restored to power where they can continue the same policies of murder, tyranny-support and atrocity-enabling that they have spent decades defending.
If you want to denounce Trump's indifference to Saudi atrocities on moral, ethical or geo-political grounds – and I find them objectionable on all of those grounds – by all means do so. But pretending that he's done something that is at odds with U.S. values or the actions of prior leaders or prevailing foreign policy orthodoxies is not just deceitful but destructive.
It ensures that these very same policies will endure: by dishonestly pretending that they are unique to Trump, rather than the hallmarks of the same people now being applauded because they are denouncing Trump's actions in such a blatantly false voice, all to mask the fact that they did the same, and worse, when they commanded the levers of American power.
"Trump's emphasis yesterday on the Saudis' value in opposing Iran provoked particular anger. That anger is extremely odd given that the iconic and notorious photograph of Donald Rumsfeld shaking hands with Saddam Hussein took place in 1983, when Rumsfeld was dispatched to Baghdad to provide arms and other weapons to the Iraqi regime in order to help them fight Iran.
His is a precise and perfectly argued brief proving the dishonest, divisive and unconscionable effort by the media and the Left, ongoing since the 2016 election, to craft a unique framework for viewing and treating the Presidency of Donald Trump, one designed to create anger, warp public perception, and to undermine American institutions. The concept is that whatever this President does is monstrous simply because he is doing it. This is the equivalent of bigotry, and applied against an elected President of the United States, is the definition of sedition. All Ethics Alarms, and now Greenwald, is demanding are consistent standards, and accurate public information to support them.
Do you have a link to the Facebook post?
"Him too" sounds more Burmese or Malay than Vietnamese.
You owe me a keyboard and a half 'a cup of coffee. Bye-the-by, Him Too would more likely be Chinese.
"Gloria got sick Monday on the bus".
I dunno. Maybe I need a better dictionary?
Si dictionariam vel traductionem requiesces, circumroga. Sinon, da nobis traductionem.
More brain freeze. That should have been "requiris", not "requiesces". I suspect all this comes of struggling to get the browser to let me key anything in at all, and then so frequently having to backspace to get back to where it dropped out parts of what I keyed in.
France in Africa was no purveyor of Human Rights…but were obvious allies in the fight against German hegemonic efforts.


What European gypsies have to teach us about sustainability and the housing market.
Real estate crunch got you in the dumps? Too broke for a boat and too proud for a trailer? Fear not, the Danish have your back.
Copenhagen-based artist and activist collective N55 just released the first prototype of WALKING HOUSE, a 10-foot-high pod home that actually walks at a strolling pace.
The solar- and wind-powered pod includes a fully-functional kitchen, toilet, living room, bed, and wood stove. An on-board mainframe computer controls the six giant legs.
Developed in collaboration with MIT, the prototype cost nearly $50,000 to make, but the team believes that as design and the production process get streamlined for larger quantities, cost will go down significantly.
Inspired by the area's large population of travelers, the WALKING HOUSE offers a unique hybrid of traditional nomadic culture and modern design solutions.
Today, the pod is taking its inaugural stroll around rural Cambridgeshire at the Wysing Arts Centre in Bourn.
We love the nomadic-living-gone-high-tech appeal of the house and its decidedly sustainable twist. The inside looks absolutely cozy — not in that Craigslist-euphemism-for-shoebox-dump kind of way. Makes us wanna curl up inside with Kings of Convenience playing oh-so-lazily in the background.


text:
Neuroscientists Just Launched an Atlas of the Developing Human Brain
Robbie Gonzalez
It's a look at how genes are expressed during the earliest stages of life—down to the cellular level.
Now we can learn much more about how the wrinkly, three-pound mass between your ears came to be.Getty images/hotlittlepotato
Your brain is one enigmatic hunk of meat—a wildly complex web of neurons numbering in the tens of billions. But years ago, when you were in the womb, it began as little more than a scattering of undifferentiated stem cells. A series of genetic signals transformed those blank slates into the wrinkly, three-pound mass between your ears. Scientists think the way your brain looks and functions can be traced back to those first molecular marching orders—but precisely when and where these genetic signals occur has been difficult to pin down.
Today, things are looking a little less mysterious. A team of researchers led by neuroscientists at UC San Francisco has spent the last five years compiling the first entries in what they hope will become an extensive atlas of gene expression in the developing human brain. The researchers describe the project in the latest issue of Science, and, with the help of researchers at UC Santa Cruz, they've made an interactive version of the atlas freely available online.
"The point of creating an atlas like this is to understand how we make a human brain," says study coauthor Aparna Bhaduri. To do that, she and her colleagues analyzed not only how gene expression varies from cell to cell, but where and at what stages of brain development those genes come into play.
Crucially, the researchers performed that analysis at the level of individual brain cells—a degree of specificity neuroscientists have struggled to achieve in the past. That's huge, in part because it gives researchers their clearest picture yet of where and in which cells certain genes are expressed in the fetal brain. But it also means scientists can begin to characterize early brain cells not according to things like their shape and location (two variables that neuroscientists have long used to classify cellular types and subtypes), but by the bits of DNA they turn on and off. As developmental neurobiologist Ed Lein, who was unaffiliated with the study, says: "This is not the first study in this area by any means, but the single cell technique is a game changer."
Lein would know. An investigator at the Allen Institute for Brain Science (a key institutional player in the mission to map the human brain, and the home of several ambitious brain atlas projects from the past decade), he and his colleagues performed a similar survey of gene expression in developing human brains in 2014. To build it, they sliced fetal brain tissue into tiny pieces and scanned them for gene expression. But even after dissecting them as finely as possible, Lein says the cell populations of the resulting brain bits were still extremely diverse. Even a microscopic speck of gray matter contains a menagerie of functionally distinct cells, from astrocytes to neurons to microglia (though, to be perfectly frank, neuroscientists aren't even sure how many cell types exist).
"When we measured the genes in our samples," says Lein, "what we actually saw was the average output of all the cells in that sample." When they were through, Lein and his colleagues had mapped the location and activity of some 20,000 genes in anatomical regions throughout the brain. But they still didn't know which individual cells those genes came from.
UCSF's new brain atlas doesn't span as many regions as the Allen Institute's (not yet, at least), but what anatomical areas it does covers it does with much greater specificity. "The difference between previous studies and ours is the difference between a smoothie and a fruit salad," says study coauthor Alex Pollen. "They have the same ingredients, but one mixes them together and the other looks at them individually."
The UCSF researchers focused on regions of the developing brain that eventually become the basal ganglia, which helps orchestrate things like voluntary motor control, and the cerebral cortex, the largest region of the mammalian brain and the seat of many human cognitive abilities. By examining the expression of individual cells from 48 brains at various stages of development, the researchers were able to trace a handful of genetic and developmental patterns to 11 broad categories of cell—and make a number of unexpected observations.
More Brain Mapping
Scientists Create an Unprecedented Map of the Developing Human Brain
Greg Miller
These Neurons are Alive and Firing. You Can Watch Them In 3-D
Megan Molteni
A First Big Step Toward Mapping the Human Brain
Katie M. Palmer
"One big surprise is that region-specific neurons seem to form very early in the developmental process," says neurobiologist Tomasz Nowakowski, who led the study. That includes neurons in the prefrontal cortex, whose formation neuroscientists have long theorized to be influenced by sensory experience. But the new atlas suggests those areas begin to take shape before sensory experiences even have a chance to take place. That's the kind of finding that could fundamentally alter neuroscientists' understanding of the structure and function of adult brains.
The project's other takeaways are too numerous to list here. But that's the thing about brain atlases: They're great at generating questions. "These things are foundational," Lein says. "The reason these atlases are valuable is you can do a systematic analysis in one fell swoop and generate 10,000 hypotheses." Testing the hypotheses generated from this latest atlas will hinge on researchers' ability to access and add to it, which is why Nowakowski and his colleagues collaborated with UC Santa Cruz computer programmer Jim Kent to visualize their database in an interactive, online visualization.
Researchers will also want to cross-reference this atlas with similar projects. After all, there's more than one way to map a brain. You can classify its neurons by shape, location, or the genes they express. You can map the gene expression of old brains, young brains, and brains of different species. A recent project from the Allen Institute even classifies neurons according to their electrical activity. Brain atlases are like puzzle pieces that way: The more you have to work with, the easier it is to see the big picture—and how all the pieces fit.
Robbie Gonzalez is a senior writer at WIRED, covering humanity's evolving relationship with science and technology. He was previously the editor of WIRED's design desk. Prior to joining WIRED he was the senior science editor of Gizmodo. Before that, he was a reporter at io9. Gonzalez holds bachelor's degrees in... Read more
TopicsNeurosciencebrainsgenetics


text:
Q: Close push menu on scroll How would I go about closing a push canvas menu when the use scrolls? or clicks off of it.
Below is the HTML and Jquery. Thanks in advance!

$(document).ready(function() {
  $menuLeft = $('.pushmenu-left');
  $nav_list = $('#nav_list');

  $nav_list.click(function() {
    $(this).toggleClass('active');
    $('.pushmenu-push').toggleClass('pushmenu-push-toright');
    $menuLeft.toggleClass('pushmenu-open');
  });
});

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A: toggle your pushmenu classes on scroll.
window.addEventListener('scroll', function(e) {
    $('.pushmenu-push').removeClass('pushmenu-push-toright');
    $menuLeft.removeClass('pushmenu-open');
});

you might want to add timer to prevent the menu from scrolling if the user accidentally scrolls before choosing a menu item (could happen on touch devices).

redpajama_set_name: RedPajamaStackExchange


This frittata is relatively easy to throw together. Herbs and cheese can be subbed out with whatever you may have on hand at the moment. It's a great way to make breakfast for the week and just cut a slice off as needed. Add ham if you wish.
2.In an 8" cast iron skillet over medium heat, add olive oil. Add potatoes and garlic to pan and cook for 5 minutes. Mince herbs and dice peppers and tomatoes, discarding juicy parts of the tomato. Add to pan and cook for 2-3 minutes.
3.Whisk milk, eggs, and salt together. Pour over tomato mixture and sprinkle with goat cheese. Cook for 1-2 minutes on stove top until bottom is set. Finish in the oven for 10-15 minutes or until egg is set.


Big Red Stables is a family business on a third-generation farm. Starting with a humble one-room cabin that is now the Bunkhouse, our farm has grown and changed over the years. We're passionate about sharing the beauty of this place with all our riders, and we work hard to create experiences that you'll cherish for years.
Here's a bit more about us!


text:
Meetings in public
Diagnostics advisory committee
Diagnostics Advisory Committee members
Find out more about the NICE Diagnostics Advisory Committee members by reading their biographies.
Dr Mark Kroese MB, ChB, DPH, FFPH, FRCP(Ed), MRCGP
Consultant in Public Health Medicine, PHG Foundation
Mark Kroese is a Consultant in Public Health Medicine at the PHG Foundation, Cambridge and was appointed Public Health Advisor to the UK Genetic Testing Network in 2006. Prior to joining the PHG Foundation, Mark worked for nearly 7 years as Consultant in Public Health Medicine at Peterborough Primary Care Trust.
His specialist interests are in the evaluation and regulation of genetic tests and the commissioning of clinical genetics services.
Ms Elizabeth Adair
Quality Director, Viapath Group LLP
Liz Adair is a qualified nurse with extensive senior management experience in the NHS, where she worked for over 32 years. She is the Director for Quality at Viapath Group LLP, a joint venture pathology services provider, where she is the lead for clinical governance assurance and quality standards.
She undertook her nursing training in London, initially at the Nightingale School of Nursing at St Thomas' Hospital, before moving to Guy's Hospital and qualifying as a sick children's nurse. She developed an interest in family mental health, qualifying as a mental health nurse in Bloomsbury Health Authority. Liz's clinical practice was predominately in child & adolescent mental health services in South East London.
In the early 1990's, Liz moved from her clinical work into a range of operational roles, initially at the South London and Maudsley NHS Foundation Trust. She transitioned into acute care and has extensive NHS senior management experience from a number of roles, including Associate Director for emergency care, medicine, women's, children's and older peoples services in East Anglia. Liz particularly enjoys working with health, social care providers and patients, in developing multi-agency patient focused strategy, redesign and implementation of system–wide care pathways.
Graduating in 2016 at Henley Business School, University of Reading with a Master of Business Administration (MBA) degree, Liz has developed an extensive cross sector network and range of interests. This includes her appointment and active participation as a Trustee of Carers Network, a charity offering support to unpaid carers in a number of London boroughs.
Mr John Bagshaw
In-Vitro Diagnostics Consultant
John Bagshaw is one of two industry representatives on the DAC. He worked for 36 years for diagnostic companies in various roles after initial employment as Company Microbiologist for a manufacturer of dialysis and transfusion equipment.
Now a freelance consultant, he is also a Public Governor for an NHS Foundation Hospital Trust and a member of the West Berkshire Patient Group and of the Mortimer Surgery Patient Panel.
John maintains his interest in In Vitro Diagnostics through membership of the Executive Board of the British In Vitro Diagnostic Association (BIVDA) and chairmanship of the Market Dynamics working group which also involves membership of the Market Research Committee of MedTech Europe.
Professor Enitan Carrol
Chair in paediatric infection and honorary consultant in paediatric infectious diseases, Alder Hey Children's Hospital
About Enitan
Enitan qualified from The University of Aberdeen in 1989. She then commenced general medicine training before switching to paediatric training in Manchester, Liverpool and Newcastle. Her doctoral thesis was on meningococcal sepsis in children. Following this she completed specialist training in paediatric infectious diseases. A lectureship at the University of Liverpool was followed by a Wellcome Trust Career Development Fellowship on invasive pneumococcal disease in Malawian children. She returned to Liverpool to take up a senior clinical lectureship in 2007, and was awarded a Chair in paediatric infection in 2013.
Her research interests include bacterial infections in children, diagnostic accuracy studies, testing of biomarker panels and early warning scores for early recognition. She has over 20 years' experience of clinical research in hospitalised children with infections. She works closely with a number of industry partners on collaborative research projects.
She was a member of our guideline development committee for sepsis and a specialist member on the diagnostic advisory committee for procalcitonin testing.
Dr Owen Driskell
Clinical Scientist
About Owen
Owen Driskell is a Clinical Scientist and the Clinical Academic Science Manager at the National School for Healthcare Science with responsibilities for Clinical Academic Development of Healthcare Scientists in the NHS. He trained and worked as a Clinical Biochemist in NHS pathology laboratories for over 10 years before joining the NIHR Clinical Research Network West Midlands as Lead for Laboratory Medicine in 2015. In this role he championed professionalism in pathology research and promoted the contribution and importance of pathology contributions to NHS research. This involved supporting the development of both the pathology services provided for NHS research and the research led by pathology laboratory professionals.
Owen's research interests are in diabetes and the use of laboratory tests. His Clinical Scientist training included the award and completion of an inaugural NIHR CSO HCS Fellowship assessing the use of HbA1c in the monitoring of patients with Diabetes Mellitus. During this time he developed an interest in the use of evidence to inform laboratory practice.
Dr James William Gray
Consultant Microbiologist, Department of Microbiology, Birmingham Children's Hospital
Jim Gray has been a Consultant Microbiologist at Birmingham Children's and Women's Hospitals since 1995. Clinical and research interests include diagnostic test accuracy studies and improving the laboratory-clinical interface, in particular to ensure that key laboratory results are reported and appropriately acted upon without delay.
Recent service innovations include the introduction of Advance Laboratory Practitioners, multidisciplinary laboratory working to support infection control and antibiotic decision making on an out of hours basis. Research interests include point of care testing for group B streptococcus screening in labouring women and improved blood culture technology to support antibiotic stewardship in neonates.
Jim has worked on several NICE Programmes, including being a member of two Guideline Development Groups and a Standing Member of a Rapid Clinical Guideline Updates Committee. He is an Expert Advisor for the British National Formulary for Children (BNF-C), and has served on a number of national committees relating to paediatric infectious diseases and antibiotic treatment. He is Editor-in-Chief of The Journal of Hospital Infection and an Assistant Editor of International Journal of Antimicrobial Agents and the Journal of Pediatric Infectious Diseases.
Dr Shelley Rahman Haley
Consultant Cardiologist, Royal Brompton and Harefield NHS Foundation Trust
About Shelley
Biography to follow.
Professor Steve Halligan
Professor of Radiology, University College London
Professor Steve Hallligan is an academic clinical radiologist working at UCL and UCLH. His clinical work revolves around gastrointestinal and breast imaging. He is a Fellow of the Academy of Medical Sciences and NIHR Senior Investigator Emeritus. He has been President of both the European and British Societies of Gastrointestinal and Abdominal Radiology.
He is Head of the Department of Imaging at UCL and has specific expertise in multi-centre pragmatic trials of imaging interventions within the NHS, for which he has received substantial funding from various NIHR Programmes. He also supervises systematic reviews and meta-analyses of diagnostic tests and obtained a PhD in 2015, related to statistical alternatives to ROC curve analysis.
Professor Neil Hawkins
Professor of Health Technology Assessment, University of Glasgow
Neil Hawkins is a Professor of Health Technology Assessment (HTA) at the University of Glasgow, Scotland. He is deputy director of the National Institute of Health Research (NIHR) funded Complex Reviews Support Unit (CRSU). His research interests include methods development for evidence synthesis and decision-analytic modelling and the use of "development focussed" HTA to support decision-making regarding the development of, and investment in, nascent healthcare technologies.
He holds post-graduate degrees in Pharmacology, Health Economics and Applied Statistics and an MBA. He has worked in the pharma, academic, and consultancy sectors in roles spanning basic pharmacological research, clinical development, epidemiology, and health technology assessment.
Mr John Hitchman
Lay member
John Hitchman is a retired Chartered Architect who was Principal of a private practice in Co. Durham. He has served on standard committees for a number of statutory and voluntary organisations and currently sits on the Lord Chancellor's Advisory Committee for the Selection of Magistrates. John is a member of the Lay Group of the Royal College of Anaesthetists where he serves on a range of the College's committees. He is also the lay representative on Peer Review Panels for the Association of Paediatric Anaesthetists of Great Britain and Ireland. John's particular interest in the NHS is the improvement of the patient experience especially for the young and the vulnerable.
Professor Chris Hyde
Professor of Public Health & Clinical Epidemiology, Exeter Test Group, University of Exeter Medical School
Chris Hyde trained in medicine and public health in London and East Anglia respectively. His expertise is in systematic reviews and health technology assessments, particularly in the context of providing support to policy-makers. In this respect he has undertaken many reports for NICE, particularly its Technology Appraisal Programme.
During his career he has set up and directed the Aggressive Research Intelligence Facility (ARIF), an effectiveness information support service for commissioners in the West Midlands. Chris has also directed the West Midlands Health Technology Assessment Collaboration and been closely involved with the Systematic Reviews Initiative of the National Blood Service. He has long-standing connections with the Cochrane Collaboration and is an editor of the NHS HTA Monograph series. He is currently based at the Peninsula College of Medicine and Dentistry where he leads the Technology Appraisal Group in PenTAG.
He has a long-standing interest in the evaluation of tests and has done health technology assessments on many topics including automated cervical screening, hysteroscopy, prediction of pre-eclampsia and pre-term birth, PET/CT, orthopantomography and identifying genetic sub-types in diabetes. He is currently part of the UK Support Unit for Cochrane Diagnostic Test Accuracy Reviews based at the University of Birmingham; and a member of the Cochrane Diagnostics Test Accuracy Editorial Board.
Dr Sandeep Kapur BSc(Hons) MBBS MRCGP(Dist)
GP, south east London
About Sandeep
Dr Sandeep Kapur is a GP in south east London. He undertook medical training at Guys & St Thomas' Hospitals following which he completed an Internal Medicine training program from Case Western Reserve University, Cleveland, USA. He is a GMC PLAB examiner, CQC GP specialist advisor and is a member of the BNF Joint Formulary committee.
Mr Patrick McGinley ICMA, CGMA
Head of Costing and Service Line Reporting, Maidstone and Tunbridge Wells NHS Trust
Patrick started as a Trainee Accountant at St Bartholomew's Hospital in 1983, and apart from a brief sojourn to the far NW of Scotland as a postmaster, has worked in the NHS ever since in a variety of roles and institutions including at the Royal London, Homerton, Whipps Cross and Great Ormond Street before moving to Maidstone & Tunbridge Wells
He is currently Head of Costing and SLR, and has implemented an automated system of calculating costs at a patient level, and firmly believes that improved costing can help the NHS to understand its business, and maximise the value of healthcare.
He has direct operational experience as a Programme Manager of an NHS Breast Screening Unit, to go with experience as a Management and Costing Accountant, and he has successfully completed two PFI projects (BLT and TWH) as financial lead to offset the significant number of hospitals that he has helped to shut over his career.
He is an active member of the HFMA Costing Special Interest Group, and is also a member of NHSI's Costing Advisory Group and technical review group, is a reviewer for both NICE and NIHR, and has presented regularly at National events on Acute Costing Standards.
He was a member of tariff calculation groups for NCAT for Chemotherapy and Radiotherapy, is a Fellow of Royal Statistical Society and a member of HSUG. He lectures on statistics for journalists for RSS. He benchmarks costing approaches with international colleagues, and is a training mentor for the Chartered Institute of Management Accountants; understandably, he is therefore rarely allowed out on his own.
Dr Michael Messenger
Deputy Director and Scientific Manager - NIHR Diagnostic Evidence Co-operative Leeds
Dr Michael Messenger is the Deputy Director and Scientific Manager for the NIHR Diagnostic Evidence Co-Operative Leeds and is responsible for overseeing the delivery of high-quality scientific evidence on in-vitro diagnostics (IVD) for the NHS.
As the Principal Healthcare Scientist on a NIHR Applied Programme Grant for Research "Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease" he has experience across many phases of the "diagnostic pipeline" including the development, validation and clinical evaluation of new diagnostic assays.
Mrs Alexandria Moseley
Alexandria holds a degree in International Finance from the Wharton School as well as a degree in product design from FIT in New York City. She has been a Wall Street trader, serial entrepreneur, business owner, industry consultant, lifestyle blogger, and health advocate.
Served for many years as an international lay reviewer for Juvenile Diabetes Research Foundation and as a member of the Diabetes Research Network, plus one year on the Lay Committee for Diabetes UK. Invited as a patient expert for two previous NICE committees formulating guidance on insulin pumps. She has a special interest in autoimmune diseases.
Dr Simon Richards PhD
VP, Regulatory Affairs, EME, Alere
Simon Richards is VP, regulatory Affairs EME for Alere. Originally a PhD Biochemist working on chemiluminescent assay techniques, he has worked in the Vaccines and Diagnostics industry for over 20 years. He began his career at Amersham/Johnson+Johnson as a scientist before transitioning into Quality and Regulatory roles of increasing seniority in DPC (now part of Siemens), Novartis, Axis-Shield and now Alere.
He is also the chair of the Regulatory Affairs Working party for the UK IVD Industry body, BIVDA.
Professor Mark Sculpher BA (Hons), MSc, PhD
Professor of Health Economics, Centre for Health Economics, University of York
Mark Sculpher has worked in the field of economic evaluation and health technology assessment for over 25 years. He has researched in a range of clinical areas including heart disease and cancer, and evaluated therapeutic and diagnostic technologies He has also contributed to methods in the field, in particular relating to decision analytic modelling and techniques to handle uncertainty. He has over 200 peer-reviewed publications and is a co-author of two major textbooks in the area.
Mark is a member of the UK National Institute of Health Research (NIHR) College of Senior Investigators. He has also been a member of the NICE Technology Appraisal and Public Health Interventions Advisory Committees. He chaired NICE's 2004 Task Group on methods guidance for economic evaluation; and has also advised health systems internationally on HTA methods including those in Ireland, Portugal, France and New Zealand. He has been a member of the Commissioning Board for the UK NHS Health Technology Assessment Programme and currently sits on the UK Medical Research Council's Methodology Research Panel.
Professor Matt Stevenson BSc, PhD
Director of the School of Health and Related Research Technology Assessment Group
Matt studied Operational Research at Lancaster University where he received his doctorate. He worked for the University of Sheffield for over 20 years, during which time he conducted cost-effectiveness analyses primarily for the National Institute for Health Research.
Matt is Director of the School of Health and Related Research Technology Assessment Group, an academic group undertaking modelling work to provide data for NICE technology and diagnostic appraisals. He is also a member of our technology appraisal committee, as well as our decision support unit.
Professor Anthony Wierzbicki BA, MA, BM, BCh, DPhil, DM
Consultant in Metabolic/Chemical Pathology, St Thomas Hospital
Professor Anthony Wierzbicki is a consultant in metabolic medicine & chemical pathology and has been director of the lipid unit at St. Thomas and Guy's Hospitals in 1994. His work in the field of atherosclerosis has led to appointments as a Fellow of the National Association of Clinical Biochemistry (USA) and the American Heart Association (arteriosclerosis and blood pressure sections). He has been a trustee of HEART-UK (the UK cholesterol charity) and chairman of this charity's medical and scientific committee.
His clinical interests are in diagnostics, cardiovascular risk quantification systems and the molecular genetics of hyperlipidaemia. He is a member of the SE London cardiac network treatment and vascular risk guideline groups.
He was a member of the writing group of the International Familial Hypercholesterolaemia guidelines. He has served at NICE on Technology Appraisal panels, the familial hypercholesterolaemia guideline group (CG71) and chaired the Lipids and Cardiovascular risk assessment guideline (CG181).
Find out more about the committee and read papers from previous meetings.
About the Diagnostics Advisory Committee
Find out when DAC meetings are held and register to attend.


text:
How Did Right-Handedness Evolve? And More Questions From Our Readers
You asked, we answered
Smithsonian magazine
How far back does right-handedness go in our evolutionary history?
Patrick Emmett
It goes way back—hundreds of thousands of years. Early stone tools indicate a right-hand preference, and so does paleolithic art. Most prehistoric handprints are of the right hand, while painted hand silhouettes are usually of the left, suggesting they were drawn with the right. Today, about 90 percent of humans are right-handed. A lesser pattern of right-hand dominance has been observed in some other living primate populations, too, such as chimpanzees.
Briana Pobiner
paleo-anthropologist, Human Origins Program, National Museum of Natural History
Black holes: spheres or disks?
John Mulkeen
West Yarmouth, Massachusetts
Black holes are spheres. But a black hole is generally surrounded by a disk of hot, bright in-falling material. That material is known as an "accretion disk."
Belinda Wilkes
director, Chandra X-ray Center, Harvard-Smithsonian Center for Astrophysics
Why are some lakes designated by "lake" first (e.g., Lake Superior) and others the opposite (e.g., Upper Straits Lake)?
Gary Dembs
Huntington Woods, Michigan
It seems to depend on who named the lake—or other geographical feature, for that matter—in question. French and Spanish explorers put the noun first and then the adjective; English-speaking explorers put the adjective first. Lake Superior was originally "Lac Supérieur" (or what an English speaker might have called "Upper Lake"). But beware; this pattern is by no means consistent. A number of recent man-made lakes have been christened in the French or Spanish manner—Lake Cumberland in Kentucky is one example that comes to mind. To some ears, that simply sounds more impressive.
Doug Herman
geographer, National Museum of the American Indian
Where do urban birds go when they die? We have lots of pigeons, sparrows and other birds where I live, but I've never seen a dead one on the street.
Edna Gross
That's because dead city birds are quickly consumed by rats and feral cats. Even in the city, it's a jungle out there.
Gary Graves
curator of birds, National Museum of Natural History
Is the amount of water on earth finite?
Wayne Rhodes
Deerfield, Illinois
Yes, it is. The water that cycles among the earth's oceans, atmosphere and land surface can be viewed as a closed system. That means that the total amount of water doesn't change. How this water originated is the subject of research. Water can be released by volcanic activity (quite a bit of which occurred as the early earth cooled), or it could have been added to the early earth from impacting objects, such as comets.
Andrew Johnston
geographer, Center for Earth and Planetary Studies, National Air and Space Museum


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Bakuon
Written by Trent L Cannon on 02 Oct 2018
Distributor MVM • Certificate 15 • Price £34.99 Bluray, £29.99 DVD
Shows like Bakuon!! (the exclamation points are important) are why I love anime so much. Sure, the perception of the genre to much of the world is shirtless men screaming and shooting lasers out of their fists (or women shooting them from....other places - Ed), but then you get a series like this that embrace the sheer impossibility of high school girls trying to find common ground together.
Bakuon!! carries on the grand tradition in anime of turning a single aspect of life into an all-encompassing thing. In this case, the entire cast is obsessed with motorcycles with the kind of fervour that is usually reserved for video games and religion. They argue frequently about which brands of bikes are the best and promise to inflict both physical and emotional pain upon anyone who disagrees. However, they eventually find peace in the universal truth that motorcycles are freaking rad.
The show revolves around a group of girls setting up a school club for getting their licenses and driving their motorcycles around town. Hane, who starts the show by making "vroom vroom" noises on her bicycle, tackles everything with the endless enthusiasm and ignorance of your standard anime protagonist, complete with not understanding that the different classes of license refer to the size of the motor rather than the rider's cup size. I swear this is a legit misunderstanding she has, and not for just a scene for a cheap laugh. The joke goes on across a couple of episodes.
As you might expect from this sort of joke, the show throws a bit of fan service at you from time to time, which feels out of place when the themes it wants to project are surprisingly wholesome. Like most teenagers, these girls are craving the freedom and independence that comes with being able to drive yourself around rather than rely on your parents as a taxi service. Motorcycles represent teenage rebellion in almost every culture and its good to see a take on it that isn't all biker gangs and drag racing. I mean, both of these things are referenced but neither is the sole focus. It's a fun, relatable subject and at times it is handled fairly well. Its just that occasionally, and I never thought I'd say this, the jiggling becomes a bit of a distraction.
The cast stays fairly small throughout the series, focusing on the interactions between the official and unofficial members of the motorcycle club. There is Rin, the Suzuki fangirl who often sports a tight fitting racing suit when she rides, Onsa, the one responsible for setting up the club and introducing Hane to the wonders of motorcycling, and Raimu, who is an incredibly skilled rider who never speaks and is always wearing her racing helmet, like a Japanese schoolgirl Stig (which is an image I didn't know I needed in my head). The most entertaining of these characters is Hijiri, who sees motorcycles as a path toward rebellion, often exclaiming that she is now a delinquent with a strange delight. She is woefully good and polite, however, often failing at her rebellions in favour of being nice to everyone around her. She is often driving around in the sidecar of her motorcycle as her family's servant takes control until she manages to get her full license.
The animation is solid throughout the series, with the sense of motion and speed that comes with a show exclusively about motorcycles. There are some fantastic details in the design and presentation of the motorcycles which add a sense of realism that shows about vehicles can lack at times. There are some dodgy CGI moments mixed in but they are sparing and not enough to cause much of a problem. The music captures the energy of the subject matter, particularly the opening theme, FeelXAlive by Sayaka Sasaki, which feels like a JPOP take on California rock, evoking my youth of lying on the beach without a care in the world. The soundtrack itself is surprisingly diverse, including rock, punk and ska inspired songs, making it one of my favourite parts of the three disc DVD set.
The show has a fun tone and, if you enjoy stories about high school girls becoming friends and can get past the copious fanservice, then Bakuon!! has a lot to enjoy. Solid animation. Interesting characters. A cute, light story to get your teeth into. Plus, motorcycles are, and will remain, freaking rad.
Clean opening and closing sequences, TV promos, and some behind the scenes footage of the directors getting reference footage of the motorcycles featured in the show.
All revved up and heading to school.
About Trent L Cannon
Trent loves any anime that spends more time having fun than making sense so... most anime, really.