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EJMO. 2019; 3(4): 263-268 | DOI: 10.14744/ejmo.2019.72964
P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia
Seyed Amir Tabatabaei1, Mohammad Ali Jalali Far1, Ali Amin Asnafi1, Farzaneh Tavakoli2, Zari Tahannejad Asadi3
1Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, 2Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3Department of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Objectives: Acute lymphoblastic leukemia (ALL) occurs due to the defective maturation of lymphoid cells and lack of differentiation. The present study was aimed to determine the prevalence of P190 BCR-ABL1 transcript in ALL patient and their relation with age, gender, and ethnicity in Iranian population. Methods: This cross-sectional research was done on 50 children with ALL including 28 (56%) males and 22 (44%) females. The presence of P190 BCR-ABL1 transcript was assessed by Nested-PCR technique. Results: From 50 ALL patients, P190 BCR-ABL1 transcript with e1-a2 fusion gene was positive in 2 (4%) cases, one patient (50%) male, and one female (50%) with <5 years old age range and Arab ethnicity. Conclusion: It seems that P190 BCR-ABL1 transcript prevalence and its relations with diagnosis and prognosis, age and ethnicity of ALL patients, need a higher population of the patients to better achievement in this field. Keywords: Acute lymphocytic leukemia, BCR-ABL1, Nested-PCR
Tabatabaei S, Jalali Far M, Asnafi A, Tavakoli F, Asadi Z. P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia. EJMO. 2019; 3(4): 263-268
Corresponding Author: Asadi Z.
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How to interpret research on ethnicity and COVID-19 risk and outcomes: five key questions
Mai Stafford
Usha Boolaky
Tim Elwell-Sutton
Miqdad Asaria
James Nazroo
Question 1: Does the report take into account the social context in which ethnicity is defined?
Question 2: What explanations does the report give for differences between ethnic groups in risk and outcomes of COVID-19?
Question 3: Are the analytical methods used appropriate for testing these explanations?
Question 4: Does the report use appropriate data?
Question 5: Who was consulted and what level of involvement did they have in the report?
Evidence on how COVID-19 is impacting on the population has helped to highlight striking inequalities in risk and outcomes across different population groups. Describing systematic differences in health outcomes between these different groups is one important step in identifying how to address inequality in society.
Studies of ethnicity and COVID-19 that are not underpinned by a strong guiding theory or that use ethnicity data superficially might contribute to perpetuating ethnic inequalities rather than simply describing them. For example, a 'kitchen sink' approach to statistical modelling to identify factors that contribute to ethnic differences in risk, in which numerous variables are thrown together without a guiding theory, obscures the complex pathways linking macroeconomic, social and public policies to outcomes.
Differences in the risk and outcomes faced by different ethnic groups can only be understood and tackled if analysis is interpreted in the context of how lives are lived and experienced, including the experience of discrimination rooted in racism. The latter includes structural, institutional and interpersonal forms of racism. Proposed explanations for ethnic differences in risk and outcomes for COVID-19 should be tested with data and with reference to the testimony of the minority ethnic groups concerned.
Studying ethnicity is a complex area and working in partnership with representatives from the affected minority ethnic communities will help to improve understanding and make research more useful to those communities and those seeking to reduce inequality.
Knowing which studies in this area are most robust can be difficult. This long read identifies five key questions to help readers evaluate reports on ethnicity and COVID-19 risk and outcomes. The issues raised are also helping the Health Foundation to develop the research it carries out and commissions.
The coronavirus (COVID-19) pandemic has brought ethnic inequalities in health to the attention of the public. These inequalities are long standing and deeply rooted. Many UK studies have shown that people from black, Asian and minority ethnic groups are at higher risk of a number of diseases. A series of reports now provides clear evidence that these same groups are also at higher risk of dying from COVID-19. One recent example is the Public Health England report on disparities in the risk and outcomes of COVID-19. This shows higher age-standardised mortality rates for people from black, Asian and minority ethnic groups compared to those of white British ethnicity. The risk of testing positive for COVID-19 is also higher for NHS staff from black and Asian backgrounds. This evidence raises fundamental questions, including what is driving these differences.
Research into ethnicity and COVID-19 is important if it can improve the health of people from black, Asian and minority ethnic groups and reduce inequalities in mortality and healthy life expectancy. Unfortunately, much research is unclear about the questions being investigated, the strengths and limitations of the data used, why data have been analysed in a certain way and how the findings should be interpreted. There has sometimes been a limited view of inequality, focusing on ethnicity without acknowledging how other factors – such as employment, occupation, socioeconomic deprivation or other dimensions of disadvantage – are patterned by ethnicity and may be part of the causal chain linking ethnicity to risk of exposure and illness from COVID-19.
Ethnicity has also been considered as a fixed, immutable characteristic. In fact, as many studies have shown, there is no genetic basis to commonly used broad categories of 'race' and ethnicity – and a person's ethnicity will heavily depend on other external factors such as place, time and culture. There is a danger that studies looking singularly at 'ethnicity' and not taking broader factors that impact health into account might contribute to perpetuating inequalities, and that policy responses may take too narrow a view about possible solutions.
To help readers critically appraise the quality of emerging research findings we identify five key questions they should ask.
To understand what drives inequalities between ethnic groups, we need to be clear about what we mean by ethnicity. Whereas classification of age or the severity of a health condition may be relatively straightforward to define, classifying ethnicity is complex.
Ethnicity classifications used by data providers such as the Office for National Statistics (ONS) or as part of routine health care in the NHS are often based on a combination of attributes, such as country of birth, skin colour, culture and religion. The categories reflect how particular groups of people have been racialised – that is, how their ethnic identity has been shaped by current and historical processes and public policies rather than how a group would identify itself. These have often negatively affected people from ethnic minorities and often have deep-rooted inequalities at their centre. The meaning of a category may also depend on place and time. To take one example, the experience of a white Irish person in England is likely to be different now than it was in the 1980s because of the social and political context at that time. Broad ethnic categories are socially constructed and do not reflect genetic differences.
Because the ethnicity categories used in research are socially constructed, health differences between ethnic groups can only be understood and tackled if we consider that social construct in research– how political and historical contexts shape the lives of people in particular ethnic groups. This context includes the impact of wider determinants of health – for example access to and experience of education, housing, and employment. And underneath all of these is the experience of discrimination – so understanding how structural, institutional and interpersonal forms of racism together shape the experiences of minority ethnic groups is important to consider in research (Box 1).
There is already research evidence linking these forms of racism to poorer outcomes for people from minority ethnic backgrounds. Compared to the white British majority, many minority ethnic groups face discrimination in employment and earnings, the quality of their housing, access to neighbourhood amenities and treatment in the criminal justice system. The fact that disadvantage is experienced by many minority ethnic groups across not just one but many of these domains, points to what has been described as 'entrenched structural and institutional racism'. Of course, studies cannot collect measurable quantitative data to model this directly and explicitly, as they cannot for other forms of discrimination. However, the interpretation of findings from studies, and ideally the methods used in analysis, should be informed by all the available relevant evidence. This includes evidence of racism and evidence from people with lived experience of being from a minority ethnic background.
If it is accepted that ethnicity classifications are crude and do not capture groupings that are natural or fixed, and that we need to consider existing evidence on the social and economic context (structures and processes) that perpetuate ethnic inequalities when interpreting study findings, what else do we need to look for in the emerging evidence on COVID-19?
Box 1: Forms of racism
Structural racism: the processes that lead to disadvantage in accessing economic, physical and social resources.
Institutional racism: the cultures of practice and procedures that shape the experience of racialised groups in institutions.
Interpersonal racism: behaviours ranging from slights and micro-aggressions to verbal and physical violence that threaten, harm and devalue those who are targeted and those with similarly racialised identities.
Source: These forms of racism have been described by James Nazroo and colleagues.
This is a crucial question, because the prior assumptions researchers make about what could be driving differences between broadly classified ethnic population groups have a fundamental impact on the methods and data used in their research. Good studies should set out and justify hypotheses, the data used and methods. Several studies have used available data to test the contribution of social, economic and health factors in explaining differences in COVID-19 risk of exposure and outcomes between ethnic groups. Alternative explanations, such as cultural or biological factors, have not yet been tested with observed data.
The evidence shows that social and economic circumstances are important factors in exposure to COVID-19 and outcomes, and help to explain much of the differences between ethnic groups. An ONS report, for example, described differences between ethnic groups after controlling for region, population density, socioeconomic deprivation in the local area and in the household, household composition, housing tenure, occupational class of the head of household and educational attainment. This report showed that differences between ethnic groups were about half as big after making these adjustments.
Underlying health conditions also explain some of the differences in outcomes from COVID-19 between ethnic groups. Analysis from the OpenSAFELY project, for example, adjusted for 14 existing health conditions known or thought to be linked to COVID-19 risk and a measure of socioeconomic deprivation. Socioeconomic disadvantage is strongly associated with increased risk of long-term health conditions that put people at high risk of serious complications from COVID-19. The high rates of existing health conditions seen in many minority ethnic groups reflect long-term exposure to social and economic disadvantage. The OpenSAFELY analysis showed that differences between ethnic groups were smaller after adjustment for these existing health conditions and deprivation, although significant differences still existed after adjustment.
Cultural factors, such as living in a multi-generational household, have been put forward as another explanation, though there is currently no empirical evidence to support this. Another broad explanation put forward to explain remaining variations between ethnic groups is that these are due to inherent biological differences in populations, such as genetics and physiological characteristics. There is no evidence to date that demonstrates specifically the genetic mechanisms of the disease, although there is evidence that certain populations with a higher prevalence of some chronic diseases, such as diabetes and hypertension in South Asian groups, are more at risk. Again, unless the mechanisms at work are explicitly hypothesised and tested using data, speculation on which biological mechanisms underly differences in COVID-19 risk between broadly classified ethnic populations is unwarranted. Indeed, unfounded speculation relating to the mechanisms of the disease can be deeply damaging to communities already experiencing social and health disadvantage.
What many studies have shown is that adjustment for multiple social and economic factors and existing conditions contributes to explaining a substantial portion (although not all) of the differences in the risk and outcomes experienced by people from the white British majority group compared to people from minority ethnic groups. Studies that focus discussion on untested, individual explanations for the increased risk of COVID-19 in people from black, Asian and minority ethnic groups – without giving weight to social and economic factors – may ultimately fail to identify the key risk factors for the worse outcomes, and might even do more harm than good.
Many of these factors, however, are interrelated and the presence of one factor could exacerbate the effect of another. Much more research is required to understand the chains of events to help us form interventions and policy responses.
As discussed earlier, studies sometimes describe differences between ethnic groups after adjustment for multiple factors, including region, socioeconomic deprivation, urbanisation, occupation, overcrowding, housing tenure and pre-existing health conditions. To do this, researchers use regression models to quantify the relationship between COVID-19 risk and ethnicity, while statistically controlling for other factors. A 'kitchen sink' approach to regression models, in which numerous variables are thrown together without a guiding theory, obscures the role and interaction of upstream and downstream factors. Complex pathways link macroeconomic, social and public policies with an individual's risk of, for example, deprivation, worklessness, overcrowding and long-term health conditions.
Analyses that 'control out' the effect of factors on the causal pathway can be highly misleading. In doing so, analysts may fail to identify key areas for intervention to reduce inequality and improve health outcomes for individuals. Rather than controlling out intermediary factors, an analysis that models causal chains can build understanding of where preventive action could be targeted. A well-designed study would explain (ideally using a theory) how and why variables are selected, where variables lie on the causal pathway, and the limitations of the analysis (such as quality and limitations of the data sources).
One example of a theory-led approach is a study of ethnic differences in diabetes. This study tested a model linking the wider socioeconomic and environmental determinants (eg neighbourhood social and physical disorder and access to health care) to intermediate outcomes, including lifestyle (eg physical activity and diet) and clinical risk factors (eg blood pressure) to establish diabetes risk. Being of black ethnicity was linked to having greater socioeconomic and environmental risk and these factors in turn were associated with having greater lifestyle and clinical risk. Lifestyle and clinical factors were strongly and directly associated with diabetes risk. From this kind of model, it is evident that focusing only on downstream interventions (eg blood pressure-lowering medication) would not address the long-standing structures and policies that result in black, Asian and minority ethnic people being more likely to live in neighbourhoods with higher levels of social and physical disorder. A similar approach was used in a study of ethnicity and likelihood of testing positive for COVID-19. That study tested whether socioeconomic factors, comorbidities, and lack of social distancing are part of the causal chain that could explain associations between ethnicity and COVID-19 risk.
Another example is a report from Public Health England (2018) that set its analysis of ethnic inequalities in health and social outcomes within a theoretical framework of structural racism as an overarching cause. The report concluded:
'The major determinants of ill-health are largely the same across all ethnic groups. However, ethnicity is a salient social [our italics] identifier in modern Britain, shaping people's networks of association and their social and economic opportunities. Further, minority ethnic identities continue, in many circumstances, to be stigmatised and subject to exclusionary forces. Therefore, without explicit consideration of ethnicity within health inequalities work, there is a risk of partial understanding of the social processes producing poor health outcomes and ineffective, or even harmful, intervention.'
Early reports on ethnicity and the direct effects of COVID-19 examined COVID-19 deaths. These studies do not help us understand whether there are ethnic differences in the risk of acquiring the infection, the risk of poor outcomes once infected, or both. More recently, studies of people with COVID-19 in the community and in primary care, and an additional analysis of published data from Public Health England, show a higher risk of infection for people from minority ethnic groups.
The recording of ethnicity can also be problematic. Ethnicity is incompletely recorded in hospital records and on death certificates in Scotland – and not recorded at all on death certificates in England, Wales and Northern Ireland. In the recent disparities report from Public Health England, ethnicity could not be established for around 10% of COVID-19 hospitalisations. Additionally, the ONS reports on deaths involving COVID-19 could not include around 10% of deaths in their analysis of ethnicity because of missing data. There is no perfect solution to handling missing data, but studies should provide information about the extent of missing data, and the sociodemographic characteristics and outcomes for people with complete and incomplete ethnicity data so that the reader can make their own judgement about any possible bias.
Given that the study of ethnicity and health is a complex area with the potential to do both harm and good, it is good practice to consider whether and how any affected communities were involved from the start of a study. In line with our earlier questions, it is useful for readers to consider whether people from affected communities contributed to shaping why the study is looking at ethnicity, how ethnicity is conceptualised, the data collection and analytical approach, and interpretation of the findings.
Existing social norms influence the questions we ask and the way that data is collected and interpreted. These need to be tested with the people whose health the study is intended to benefit. Although meaningful engagement with affected populations is not straightforward and can require us to confront tensions and balance interests, as well as acknowledge our own unconscious bias, it is part of a well-designed study. The challenges of engagement are even greater during the pandemic, but support is available for NHS and clinical researchers to do this. Work undertaken in partnership with representatives from the communities experiencing these inequalities has the potential to improve their health outcomes, increase public trust and make better use of public resources.
The five questions set out should help readers to evaluate the emerging evidence on COVID-19 and ethnicity. In evaluating this evidence, it is important to remember that all analysis to test explanations for ethnic differences in COVID-19 risk should start with a set of hypotheses, with the assumptions underpinning these made explicit. In addition, a theory-led approach is vital, as well as appropriate data to test the theory, and an inclusive research practice to help frame the research questions, design and interpretation appropriately.
It is commendable that the research and analytical community has acted quickly to develop an evidence base on ethnic inequalities in COVID-19 risk and outcomes, but it is also a field in which research can do harm as well as good. The five questions discussed are aimed at consumers of research, but rigorous standards are also needed for those carrying out studies on ethnicity and health. Standards, however, are starting to emerge and these include guidance for researchers, journals and reviewers and detailed checklist guidance to help authors and reviewers improve the quality of published research. Until these standards are more widely adhered to, the onus will be on readers to make their own careful evaluations of these studies.
Note: This long read was amended on 2 September 2020 to correct a reference to the OpenSAFELY project.
2. Question 1: Does the report take into account the social context in which ethnicity is defined?
3. Question 2: What explanations does the report give for differences between ethnic groups in risk and outcomes of COVID-19?
4. Question 3: Are the analytical methods used appropriate for testing these explanations?
5. Question 4: Does the report use appropriate data?
6. Question 5: Who was consulted and what level of involvement did they have in the report?

redpajama_set_name: RedPajamaCommonCrawl


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Community JDC Joins Post-Hurricane Relief Effort in Haiti
JDC Joins Post-Hurricane Relief Effort in Haiti
By Hamodia Staff
Monday, October 10, 2016 at 5:49 pm | ח' תשרי תשע"ז
NEW YORK -
In the wake of widespread destruction left by Hurricane Matthew across the island of Haiti, the historic Jewish charity, the Joint Distribution Committee (JDC), was among the many humanitarian organizations that partnered to bring relief to the disaster-stricken population.
"Our hearts go out to the people of Haiti, and the wider region, in the wake of Hurricane Matthew's devastation. All too familiar with the acute needs facing Haitians, JDC activated its network of international and local partners and is mobilizing relief efforts in an expression of humanitarian solidarity and Jewish values," said Alan H. Gill, JDC's CEO.
As of Monday, death tolls in Haiti had reached as high as 1,000, according to some reports. Over 30,000 homes have been destroyed and the United Nations reports that 350,000 Haitians are in need of assistance
JDC's efforts are carried out through an on-the-ground partner, Heart to Heart, a Kansas-based non-profit organization that specializes in crisis relief. Its efforts have focused on Haiti's southern region, the area most affected by the storm. The organizations are focused on providing desperately needed medical assistance, particularly in areas where severe food shortages and fears of outbreaks of water-borne diseases such as cholera have exacerbated the level of urgency.
Presently, three medical teams have been dispatched to the Sud (southern) province and a forth is operating in Western Haiti.
At the time that Matthew hit the island, it was rated as a Category 4 Hurricane with 145 mph winds and 50-foot waves. In addition to claiming lives and damaging property, it disrupted cell communications and caused major infrastructure damage to key bridges, airports, and roads.
Haiti, the Western Hemisphere's poorest nation, is no stranger to natural disasters. In 2010, a massive earthquake claimed over 100,000 lives and destroyed an estimated 250,000 homes and commercial buildings. Then too, JDC joined the large international relief effort providing food and water supplies, medical treatment, psychosocial support, job training, and education for more than 400,000 among the stricken population.
The JDC was first formed in 1914 to aid Jewish communities that had been affected by the First World War, focusing on the isolated population living in Palestine. In the years following the Holocaust they took a leading role in providing aid to refugees and were especially active within DP (displaced person) camps in Germany.
In recent years, they have partnered with several international organizations to provide aid to nations struck by large-scale humanitarian crises including Ecuador, Macedonia, Italy, Nepal, the Philippines, Japan, and Southeast Asia.
"Our response to this crisis is especially poignant during the Jewish High Holidays, when we examine carefully our actions in the last year and recommit to our obligation as individuals and a global people to aid those in dire need," said Mr. Gill.
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Home Entertainment Sylvester Stallone won't return in Creed 3 as Rocky Balboa
Sylvester Stallone won't return in Creed 3 as Rocky Balboa
The Creed saga will continue in its footsteps without Rocky Balboa. Sylvester Stallone will not appear in Creed III, the next film in the series starring and directed by Michael B. Jordan.
Stallone's representative confirmed his absence in the upcoming film to The Hollywood Reporter. No explanation has been given or the possible reasons for this decision have been commented on at the official level.
This will make Creed 3 the first film in the series in which Sylvester Stallone does not make an appearance. Stallone earned an Oscar nomination in 2015 for Best Supporting Actor for his portrayal of Rocky Balboa in Creed, directed by Ryan Coogler. He was also nominated for Best Actor for his original role as Rocky in 1976, 39 years earlier.
Although this is the first official statement confirming that Sylvester Stallone is out of the movie, The actor already made a statement in 2018 in which he confirmed the retirement of the character. Stallone said goodbye to Balboa with a video posted on his Instagram account coinciding with the release dates of Creed II.
"I just want to thank everyone around the world for holding the Rocky family in their hearts for over 40 years. " Stallone wrote in the caption. "It has been my greatest privilege to have been able to create and play this significant character".
Stallone has played Rocky in eight movies: Rocky I, II, III, IV and V, Rocky Balboa, as well as Creed I and II. He also directed four of the six Rocky films and served as a screenwriter or co-writer on all of the Rocky and Creed II films.
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Meanwhile, Michael B. Jordan will reprise his role as Adonis "Donnie" Johnson Creed in Creed III. Jordan is in charge of the project, which will mark his directorial debut. Tessa Thompson will also return for the sequel.
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Sheriff will ask FBI to take over remains recovery
Jennie Rodriguez-Moore
STOCKTON - San Joaquin County Sheriff Steve Moore will invite the FBI to take over the recovery operation for the remains of victims connected to serial killers Loren Herzog and Wesley Shermantine, he said Tuesday.
Moore's statement at a county Board of Supervisors meeting followed appeals from Assemblywoman Cathleen Galgiani and the mother of a murder victim that the Sheriff's Office hand over the digging operating to the FBI, saying it is better equipped to handle the recovery effort.
The notorious killers' methamphetamine-fueled murder spree ended in 1999, when authorities caught up to the childhood friends.
Moore said he has "no problem" asking the FBI to assume all responsibility for excavating sites where Shermantine has taken FBI agents on a search for the remains of victims.
The issue of transferring the job arose after Moore proposed supervisors approve $126,000 for a contract to drill and shore a well in the Linden area. The FBI would reimburse the county 50 percent of that cost.
Those plans drew criticism from families of victims and of people who believe their missing loved ones could be the victims of Herzog and Shermantine.
Joan Shelley, the mother of JoAnn Hobson, expressed her support for an FBI takeover during a public comment period at Tuesday's Board of Supervisors meeting.
Hobson's remains, discovered recently in a Linden well after she vanished in 1985 at age 16, had been returned to her mother commingled with bones from at least three other victims, according to an independent report.
"I don't want the rest of the families to go through this," Shelley told supervisors.
Shelley sent her daughter's remains to California State University, Chico, where a forensic anthropologist found the use of large earthmoving equipment contributed to the mix of skeletal remains.
Shelley is skeptical that Moore will move forward with the request.
"I'll believe it when I see it," she said. "There's enough dilly-dallying going around."
Sue Kizer, whose daughter, Gail Marks, is thought to be a victim, worries that the Sheriff's Office might use heavy-duty equipment again. Marks' body has yet to be found.
County supervisors unanimously approved Moore's request for the money appropriation and gave Moore two weeks to try to get the FBI to assume full responsibility of excavations.
"We do want to expedite this," Supervisor Ken Vogel said.
Moore said the Sheriff's Office has been cooperating with the FBI to recover remains since March.
Prior to that, the Sheriff's Office had conducted digs in Linden and Calaveras counties.
"If they want to come in to take it over, that's fine with me," Moore said after the meeting. "If they want to assume all the costs, that's also fine with me."
Moore said the FBI is fully aware of concerns about mixed remains that arose after those digs.
He said the proposed excavation discussed Tuesday employs a different method selected by the FBI.
"I think the method selected will eliminate that concern," he said. "We're focusing on doing our job, and we take our responsibility very seriously."
Galgiani says families have been under the impression that the FBI has been fully involved already in all aspects of the case since March 2.
That's the day Moore announced the FBI's Evidence Recovery Team would be assisting with excavations.
Galgiani on Tuesday sent a letter to Herb Brown, the special agent in charge of the FBI's Sacramento office.
In that letter, Galgiani said Brown told her homicide investigations are handled by state and local authorities.
She said Brown also said the FBI might investigate serial killings if the head of a law enforcement agency with investigative or prosecutorial jurisdiction requests it, and that the FBI would pay for all aspects of the recovery effort.
Galgiani is asking Brown to verify those statements in writing.
"No one agency alone can realistically be expected to handle an excavation of multiple sites with the complication that involves multiple victims," Galgiani said after the meeting.
The FBI works with advanced technology, more resources and higher-level experts in the field, she said. And there are four more sites identified to federal authorities by Shermantine that still need to be unearthed.
"This is an unprecedented case," she said.
Contact reporter Jennie Rodriguez-Moore at (209) 943-8564 or jrodriguez@recordnet.com. Visit her blog at recordnet.com/courtsblog.


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The exercises are conducted through the acquisition of targeted skills, such as support for the development of specific solutions and semester projects. In the exercises students work with software, focusing on applications in geodesy.
MacroGeo – affords resources for preparation and upkeeping of information system datas about area, creation of big scale maps, technical digital maps and the like. The system is upkeeping databases of bench marks and minor points for a next operation.In measurement processing from a digital measuring device book or from data file and following inseting to MacroGeo system it is possible to use data coding. Dulmap affords resources for quarry modelling with possibility of mine map creation according to responsible technical legislation.
Exercise: MacroGEO 1. The choice of location. 2. Functions for working with files and a list of coordinates. 3. Definitions of categories and groups .. 4. Drawing, choice groups, libraries spot symbols. 5. Map sheets. 6. Creating special maps. 7. Construction. 8. Print.. DULMAP 9. Logic processing. Brief overview of features for creating digital maps. DMT 10. Preparing input data 11. The generation of triangular grid. 12. Calculation of the contour, drawing contour maps. 13. Working with bitmaps. 14. Processing of terrain profiles. 15. Print the resulting drawings and data into information system.


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Pam Moore
Boulder, COpam-moore.com pammoore.contently.com
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Ingenious Collaboration
Jim Edmunds wasn't sure what his next step would be after graduating from Whitman College.
"Like a lot of students, I was sort of a blank slate as to what I was going to do," he says. At the time, he didn't see himself creating a company that would ultimately give back to both Whitman and to the greater Walla Walla business community.
Fast-forward 44 years, and not only is Edmunds the founder of software firm Ingeniux, his company is helping create technology to support regional entrepreneurs...
Gyms are going 'green,' but are they actually eco-friendly? Here's what to look for.
As wildfires, floods, hurricanes and other climate-related disasters grow more frequent and severe, many people think businesses need to step up their sustainability efforts. According to a 2015 Public Affairs Council survey, 59 percent of Americans believed major companies were generally not doing a good job of protecting the environment.
Some fitness facilities are trying to do their part. In April 2021, for example, gym chain Life Time updated its five-year sustainability plan. The company...
Lonely after a move? Or just in need of more friends? Try these tips for connecting.
Americans are on the move, in a pandemic-related phenomenon that real estate experts have dubbed the Great Reshuffling. A July 2021 Post-Schar School poll found that 17 percent of Americans had moved since the pandemic started, while more than 1 in 4 had considered taking the plunge. In many cases, this means that Americans are seizing the chance to live in newly affordable cities or to stake out space for themselves in suddenly thriving exurbs. But even if a move is positive, relocating, par...
How to Change Your Mindset About Sleep
If your sleep life tends to not be great and you find yourself dreading bedtime, it's time to flip the script. Your thoughts about sleep can frame what happens when you shut your eyes. Will it be the restful night you need, or are you in for hours of tossing and turning?
Sleep can go awry for many reasons. While changing your sleep mindset can't counteract poor sleep habits or a health issue that's keeping you up, your expectations do matter.
Yale Medicine behavioral sleep medicine expert Sus...
spineuniverse.com
Spine Jack Procedure Gets Entrepreneur Back to Work
After a debilitating ski accident, Ben Davis trusted his instincts — and found a surgeon he could believe in.
In 2021, Ben Davis, 39, saw himself falling into a depression. His Lafayette, Colo. Window washing business had survived the COVID-19 shutdowns, only to be threatened when a ski accident stopped Ben in his tracks. "I was watching tens of thousands of dollars slip away," he recalls. With back pain so severe he could hardly think straight, Ben was cancelling clients left and right. "I r...
How to do your first pull-up, and why you should try
You might think of pull-ups as an upper-body exercise you'd never have the strength to tackle, but your first one might be closer than you think. While you need full-body strength, tenacity and patience to master the move, according to Angela Gargano — a certified personal trainer, four-time "American Ninja Warrior" contestant and founder of Strong Feels Good — it's worth it. "Being able to lift yourself above a bar is invigorating," she says.
Pull-ups, which require you to hang on to a bar u...
Whitties Helping Whitties: A Great Return on Investment
When Michelle Mathieu '92 was approved to join the Clubhouse networking app by Sam Geschickter '20 in January 2021, she was pleased—and slightly perplexed. Mathieu, whose promotion from chief investment officer of Fulcrum Capital to chief executive officer becomes official Jan. 1, 2022, had been wanting access to the then invite-only platform, but Geschickter's name didn't ring any bells—which is understandable, given the timing.
Not long after the two met at a 2020 Seattle Whitties Helping W...
E-bike etiquette: Respect the rules of the road (and trail) with these tips
The pandemic has come with many disruptions — not all of them bad. One example is the spike in popularity of electric bicycles, which are like regular bicycles in every way but one: They are equipped with a battery and motor that allow riders to pedal with less effort. In the first half of 2021, sales of e-bikes were up 64 percent compared with the same period in 2020.
According to Megan Hottman, a.k.a. the Cyclist Lawyer, "e-bikes really are the future of transportation in so many ways." The...
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Work Out Like a Firefighter
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Cannabis Highness: How Long Does It Last?
You probably must have heard about the highness associated with cannabis. Right now, you think you're ready to have your first encounter with this thing called weed. You want to have this experience, but somehow you are not sure of how long it will take for the mind-altering effects of the herb to wear off.
Fortunately, if you are interested in consuming cannabis through inhaling, then the effects don't last very long. However, if you're thinking of going for the Edibles, that's a different pot case.
To understand how long it takes for the effect to wear off and what to expect after that, keep reading the content.
How long Am I going to be High?
For new users, this experience can be little at the extreme; this is because when inhaled tetrahydrocannabinol (THC), the potent constituents, rushes into and saturates the brain in a matter of minutes.
Within few minutes – say 15 minutes of inhaling the weed the effects kicks in, it rides itself out and starts waning within the course of one to three hours.
However, this is not the case when cannabis is ingested orally; you only get to feel the effect take hold anywhere from 30 minutes to 2 hours. It takes anything between four to eight hours to run its full course.
In summary, how long the effects of the herb last in the body system is dependent on the mode of consumption.
Are there any other effects after the Highness?
The potent ingredient of cannabis, the THC has a long half life — the half-life of a drug is the length of time it will take for the compound to reduce its concentration in the bloodstream. Even though the severe effects of cannabis does not last for long, you could get little high after the initial highness.
Unlike the alcohol hangover, a cannabis hangover merely makes you feel a little tired. But with a good rest, plenty of water, and some healthy diet it goes away.
What's the effect of Cannabis on Teens?
According to Dr. Francis Jensen, author of The Teenage Brain, Cannabis affects teenagers differently and longer than it affects adults. This is so because cannabis stays longer in the brain of the adolescents which may lead them to experience the mind-altering effect for a far longer time.
A quick recap, the effects of cannabis is short-lived, which means you should expect it to wear off within few hours. However, the herb can make you feel tired when you had consumed it in large quantities. This mind-altering effect has been shown to last longer in teens and adolescent. Hence, the recommendation to hold off using cannabis until adulthood.


A police sergeant has been injured at Ho Chung by a gin trap hidden in mud, despite his strong boots. He was on an illegal immigrant search with colleagues when the incident happened. He was taken to hospital. Another officer stepped on a second gin trap but was not hurt.


That said, Windows 10 makes it possible to disable the System Protection and thus make system restoring unavailable if a user should wish to do that. It's not recommended by us to do that unless you have a particular case where it makes sense because you may want to take a System Restore one day and will find it impossible to do so. You shouldn't solely rely on the chance of making system restore as your backups or system images. There are some times when it can leave you without data—for example if you need to restore the computer back to a time that is before you had installed something that you required on the computer, and it's the only restore point available for getting the computer working again. That's why you should still be familiar with backing up and system images (Macrium Reflect  is a great tool for the latter.) But the option for taking system restore is still a feature that many people have known from Windows for a long time, and they enjoy it still being around.
Start by opening the Control Panel  and then click on the "Recovery" link from the menu. It opens you up to the Advanced recovery tools menu where you get three more links. Click on the one that says "Configure System Restore" to find the System Protection area.


Many Japanese corporations that demonstrated wrongdoings have poorly responded to public criticism and were subsequently dragged into various corporate crises. The managers in these corporations did not speak or behave in a responsible manner during the crises. In addition, they also offered negative views on corporate social responsibility (CSR) years before the crisis, disqualifying them from being considered responsible corporate citizens. By using a genealogical analysis, the author investigates their views on CSR and CSR-related activities before the crisis. In this study, the author conducts an analysis of Toyota's recall crisis in 2010 as an example.
CBS News. 2010. Toyota Has Donated to Investigating Reps. Last modified February 23. https://www.cbsnews.com/news/toyota-has-donated-to-investigating-reps.
CBS News. 2011. Electronics Not at Fault in Toyota Deaths. Last modified February 8. https://www.cbsnews.com/news/electronics-not-at-fault-in-toyota-deaths.
Keidanren. 2011. Keidanren Homepage. Accessed September 1, 2011. http://www.keidanren.or.jp/indexj.html.
Keidanren. 2017. Keidanren Homepage. Accessed August 9, 2017. http://www.keidanren.or.jp/en/profile/pro001.html.
Ministry of Land, Infrastructure and Tourism (MLIT). 2010. Press Conference on February 5. Accessed September 1, 2010. http://www.mlit.go.jp/report/interview/daijin100205.html.
Toyota Motor Corporation. 2008. CSR Policy: Contribution Towards Sustainable Development. Accessed September 30, 2008. http://www.toyota.co.jp/en/vision/sustainability/index.html.
Toyota Motor Corporation. 2018. Guiding Principles at Toyota. Accessed June 11, 2018. http://www.toyota-global.com/pages/contents/company/vision_philosophy/pdf/guiding_principles.pdf.


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the national circus Sept. 27, 2019
The Case for a Fast, Focused Trump Impeachment
Photo: Andrew Harrer/Bloomberg via Getty Images
Most weeks, New York Magazine writer-at-large Frank Rich speaks with contributor Alex Carp about the biggest stories in politics and culture. Today, the strategy behind the impeachment proceedings, the widening circle of the Ukraine cover-up, and how the media might aid in Trump's defense.
The Democrats' impeachment strategy seems to be shaping up to focus on Donald Trump's interactions with Ukraine only, leaving aside any other potentially impeachable conduct, including the findings of the Mueller report. Is this the right way forward?
Two principles apply here: (1) When a runaway boulder is heading toward you, get out of its path. (2) When Nancy Pelosi commits herself fully to a strategy, ditto.
The boulder was set loose when the White House's pseudo-transcript of Trump's shake-down phone call with the Ukrainian president, even in its no-doubt doctored form, pointed to the commission of a crime and confirmed the whistle-blower complaint released 24 hours later. This latest Trump violation of the Constitution is a gripping and representative story that is simple to grasp, doesn't require reading a "report," is replete with a coverup at least as felonious as the crime itself, and is packed not only with well-known wack jobs like Rudy Giuliani but obscure players who are about to be yanked out of the shadows for close-ups in prime time. That latter category includes flunkies in the State Department like the ambassador Kurt Volker and the delightfully named Mike Pompeo adviser T. Ulrich Brechbuhl, who witnessed crimes and may well be guilty of abetting them.
No one needs to hear from me that Pelosi knows what she's doing. She surely recognizes that one of the problems with a multi-strand impeachment inquiry is that there are so many potential charges against Trump and the grifters in his White House circle (family included) that it could take a decade to get to the bottom of them. She also has to reckon with the reality that there isn't a ton of talent in her caucus that's up to so demanding a job. For every capable and focused inquisitor like Adam Schiff, there are many more who, as we saw in Thursday's hearing with the acting National Intelligence director Joseph Maguire, are prone to showboating, losing the forest for the trees, repeating each other, and, in general, hiding rather than advancing the prosecutorial ball.
There's no time for this. Speed is of the essence for several reasons. In a nation attuned to binge watching, we like our stories to play out without interruption. What's more, speed is the organic pace of a modern impeachment. Less than eleven weeks separated the opening of the House Judiciary Committee's formal impeachment hearings on Richard Nixon in 1974 and the committee's first vote on an article of impeachment. That same process took just under ten weeks in the Bill Clinton impeachment of 1998. Both efforts were narrowly focused even though in both cases the sitting presidents' adversaries had other charges they were panting to adjudicate.
In both cases as well, the calcifying of public opinion sped up in tandem with the narrative, leading to a clear majority verdict and forcing cautious party loyalists to fall in line. The slow burn of the Nixon impeachment narrative may foreshadow Trump's. It took until three months before Nixon's resignation for three Republican senators to muster the nerve to call for his exit — three senators, not so incidentally, who were up for reelection that year. In Clinton's case, his approval rating started skyrocketing in direct proportion to Newt Gingrich's impeachment putsch, leading to the failure to convict in the Senate and a GOP political debacle. In the instance of Trump, we are already seeing the start of a shift in the polls, with major surveys this week showing for the first time that the country is evenly divided on impeachment rather than opposed.
Another argument for speed is that it's a smart play to strike when the White House is on the mat. It's an indicator of the overall disarray that Trump released the incriminating phone readout without even recognizing how incriminating it is. The ranks of the presidential bubble/bunker have dwindled down to heel-clicking sycophants who didn't even think to put an impeachment war room in place. The fact that Corey Lewandowski's name is being floated as its potential general indicates the bargain-basement caliber of talent available for such an assignment. It's indicative of the shortfall that Trump and his GOP defenders have been reduced to recycling nearly half-century-old lines from Watergate. The Nixon White House spokesman Ken Clawson — to take one representative example — decried that investigation as a "witch hunt" ginned up by "people who were completely rejected at the polls" and were "trying to bring down this presidency."
This week we've also seen the White House accidentally send its pathetic talking points to the Democratic congressional leadership and then, even more haplessly, attempt to "recall" the errant email once the blunder was revealed. The president who has declared war on leakers can't even stop his own staff from leaking in broad daylight via a mass email blast. And let's not forget the farcical White House effort at the start of the week to throw Rudy under the bus: Instead of making Giuliani the fall guy, Trump and his lackeys have instead spurred him on to grab any and every media opportunity to compound the charges and underline Trump's guilt.
As the wheels are falling off at the White House, so they are spinning out of control in Trump's already addled brain. It's hard to see how his threatening whistle-blowers with death or calling Adam Schiff "sick" accomplishes anything beyond making the case that he is incapacitated and should be removed by the 25th Amendment — a solution also considered by some Republican senators as an impeachment alternative for Nixon. A Washington Post article this week quoted a former presidential aide as worrying that Trump's fury "may lead to less structured output from the White House." Given that there's already no structure in the White House "output," it beggars the imagination to wonder what's in store.
The whistle-blower's complaint is aimed primarily at Trump, but also mentions incriminating details about Attorney General Bill Barr, White House officials who tried to bury knowledge of Trump's call with Ukraine, as well as Giuliani. Trump has also made comments attempting to rope in Mike Pence. Will any of them make it out of this intact?
No one will emerge with his reputation intact. But as we reach the every-lawyered-up-man-for-himself mode, the race is on to see who will emerge with limited or no criminal exposure. It's worth noting that at least four lawyers may have been part of the Ukraine cover up — whether the effort to bury Trump phone-call transcripts in a top-secret computer server or the attempts to bury the whistle-blower's complaint: Barr, Steven Engel (the director of the Office of Legal Counsel), Brian Benczkowski (head of the criminal division at Justice), and Pat Cipollone (White House counsel). This is another Watergate rerun. There were 14 lawyers brought down by Nixon administration scandal, including Nixon and his vice president, Spiro Agnew, and two attorneys general, John Mitchell and Richard Kleindienst. All were punished — either with prison time, disbarment, or suspension of their license to practice law.
As for Pence: If Trump goes down and he goes down with him, Pelosi becomes president. Just saying.
Noting the assistance that disinformation and "both-sides" reporting has given to Trump during past crises, media critics are noting that Trump's defense may rely heavily on how events are framed by both the right-wing and mainstream media going forward. Is today's media ecosystem up to the challenge?
The consternation about today's media ecosystem failing to meet the challenge is nothing new. People are tending to forget that the Lewinsky scandal broke when partisan and competing 24/7 cable-news operations were new inventions: Both Fox News and MSNBC made their debuts in 1996, ending CNN's monopoly just in time to pour gasoline on the growing flames of impeachment. They did not exactly distinguish themselves in the ensuing frenzy, and they were joined by such right-wing organs as the Wall Street Journal editorial page, which published conspiracy theories that included implicating Bill Clinton in alleged drug-related murders in Mena, Arkansas.
Toss in the internet and today's full panoply of warp-speed social media, including the Russian-enabled schemes of the Trumpist far-right, and it's not going to get better! Still, there is some fun to be had at Fox News, where, as Gabriel Sherman has reported for Vanity Fair, open warfare has broken out among its onscreen personalities. But Fox won't be reformed, and it's safe to say that it won't be determinative in the Trump saga: Its viewers are the voters who will remain loyal when he pulls out that gun on Fifth Avenue, and nothing will change that. Nearly a quarter of Americans remained loyal to Nixon even after he resigned.
More happily, we have two great news organizations locked into a competitive battle to get this story right. The New York Times has every incentive not to repeat its history of losing Watergate scoops to the Washington Post. We all benefit from both papers' nonstop journalistic enterprise. But there's a caveat: These organs aren't perfect, and they are at their worst when their efforts to show "both sides" leads to journalistic malpractice. The Post, for instance, countenances the regular contributions of Hugh Hewitt (also a contributor at NBC News), who this week could be found tweeting out an unsubstantiated allegation about Hunter Biden's sex life (in America, not Ukraine) that even if true would be irrelevant, given that he is a private citizen who is not running for public office. That should be a firing offense. The Times, meanwhile, is under rightful ridicule for its anecdotal articles in which ordinary voters in homespun rural settings explain their loyalty to Trump in terms that often sound lifted from either Hillbilly Elegy or the collected works of that ubiquitous Trump-voter media chronicler Salena Zito. The good news is that this week a humor columnist at the Post, Alexandra Petri, may have demolished the genre for good with a piece headlined "Trump's Getting Impeached? I Defy You to Convince Anyone at This Cursed Truck Stop." If you're seeking a laugh in this grim week for the Republic, look no further.
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More on the Trump-Ukraine Scandal
Trump's Impeachment Trial and the Verdict of History
Trump Fires Impeachment Witnesses Alexander Vindman and Gordon Sondland
Trump Impeachment Hearing Schedule: What's Next?
the national circus
frank rich
trump impeachment
Frank Rich: The Case for a Fast, Focused Trump Impeachment


At about 9:40pm, on Thursday, May 24, 2007, officers from Area D-4 (South End) responded to a radio call for a larceny in progress at 147 Massachusetts Avenue. On arrival, officers spoke to the victim who stated that an unidentified black male, wearing a red Hawaiian shirt, exited a motor vehicle, approached her and then took her purse. The suspect then jumped back inside the car and fled.
Approximately, four months later, on Tuesday, August 28, 2007, the same victim from the above incident called police to report that the man who robbed her on May 24, 2007, was standing in front of the Store 24 on Massachusetts Avenue. Officers responded and located an individual matching the description provided by the victim. After being positively identified by the victim, the suspect, Jerome Spencer, 39, of Boston, was arrested and charged with Unarmed Robbery (Purse Snatching).
At about 5:15pm, on Tuesday, August 28, 2007, officers from Area C-6 (South Boston) observed two individuals milling around the area of Linskey-Barry Court. This area has been the source of numerous complaints attributed to trespassing, loud noise and public drinking. As such, officers approached the two individuals. While speaking to one of the individuals, officers asked if he lived in the development. To which, the suspect replied, "No, I do not." When officers conducted a search of the suspect, officers discovered a knife with a blade longer than 2 ½" in length. Officers then arrested Joseph O'Reilly, 18, of South Boston and charged him with the Possession of a Dangerous Weapon (Knife) and Trespassing.


On Oct. 31, 2017, Battelle, a non-profit research and development organization, announced that it had received a marijuana research license to study the behavioral and physical effects of marijuana consumption on human subjects, making it one of the few non-University holders of such a license.
The National Institute on Drug Abuse will supply Battelle with marijuana that has been grown by the University of Mississippi, the only DEA-approved cultivator of marijuana in the U.S. While the DEA denied a petition in 2016 to reschedule marijuana, it followed that decision with the announcement that it was going to increase the number of DEA-approved cultivators for marijuana research; however, the DEA has yet to name any new cultivators.
Battelle, an organization that has studied tobacco for more than 50 years, will initially conduct research to determine if there is a link between tobacco and marijuana use and how people use tobacco products, such as blunt wraps, to consume marijuana.
This past summer Battelle announced that it would be researching opioids and marijuana in an attempt to discern potential usage patterns and trends.


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Stamkos dazzles as Lightning book 3rd consecutive trip to Stanley Cup final with win over Rangers
Posted on June 11, 2022 by JetsFan in NHL News | 0 Comments
The Tampa Bay Lightning's bid for a three-peat is alive and well.
With captain Steven Stamkos leading the way, the two-time defending champions beat the New York Rangers 2-1 in Game 6 of the Eastern Conference final Saturday night, securing a berth in the Stanley Cup Final for the third straight year.
"It's going to be tough to get out of the moment and look back and realize what a special group we have here because there's still some games to be played," Stamkos said. "You're still not at the end of our goal, but in saying that this group is pretty amazing and pretty special."
Stamkos scored two goals and Andrei Vasilevskiy had 20 saves for the Lightning, who won the series 4-2 — winning four straight games after losing the first two on the road — and will face the Colorado Avalanche in the Cup final.
Game 1 is Wednesday night in Denver.
"It's probably not the greatest word to use, but I'm damn impressed by this group," coach Jon Cooper said.
"It's impressive what they've done. … I'm just utterly impressed by what they do to win a hockey game," the coach added. "And the fact that they they have every excuse in the world to not win because nobody would fault them by saying hey, you won one, you won two, and to come back and and go for a third. I'm impressed."
So the @NYRangers tied it… and then the @TBLightning took the lead back 21 seconds later… 😳 #StanleyCup

🇺🇸: @espn ➡ https://t.co/Q6pgX3WR7C
🇨🇦: @Sportsnet ➡ https://t.co/5TI9QXKueT pic.twitter.com/Qr4SZtNcKv
—@NHL
Stamkos put the Lightning ahead for good in the third period just 21 seconds after New York's Frank Vatrano scored on the power play with the Lightning captain in the penalty box for holding.
Nikita Kucherov and Ondrej Palat assisted on the winner with 6 1/2 minutes left, with the puck deflecting off Stamkos' knee into the net after Rangers goalie Igor Shesterkin stopped the initial shot.
Stamkos also scored on a wrist shot from the top of the right circle midway through the second period.
"I obviously was a little disappointed in myself for taking the penalty. … It's easy to say now, but for some reason I wasn't as rattled as I usually am in those situations," Stamkos said. "I was just confident in our group that we would find a way, whether it was in regulation or was in overtime. We deserved to win the game. That was the feeling we had from puck drop."
Steven Stamkos scored to give the @TBLightning a 1-0 lead. Tampa Bay owns an all-time record of 19-3 when scoring first in a potential series-clinching game (2-0 in 2022). #StanleyCup#NHLStats: https://t.co/rOAdC80NHW https://t.co/llG5yjQEEV
—@PR_NHL
The Lightning are the first team to make three consecutive appearances in the Cup final since Edmonton did it from 1983-85. They are trying to become the first to win three straight championships since the New York Islanders claimed four in a row from 1980-83.
The Rangers, down 3-2 in a series for the third straight round, were 5-0 in elimination games this postseason before Saturday night.
The only teams to win more elimination games in a single postseason were the 1975 New York Islanders (eight), 2014 Los Angeles Kings (seven) and 2003 Minnesota Wild (six).
"It's hard right now. But we played well, we battled hard, we had a chance to win all those games," Rangers coach Gerard Gallant said. "They found a way to get the big goal at the big time."
New York dropped three of the first four games before winning three straight elimination games to beat the Pittsburgh Penguins in the opening round. They lost the first two on the road at Carolina before rebounding to oust the Hurricanes in seven games to reach the East final.
It was a different story Saturday night, with the Lightning limiting New York's scoring opportunities while outshooting the Rangers 31-21.
Vasilevskiy went long stretches without being tested. He faced just seven shots in the opening period, six in the second and eight in the third.
Shesterkin, meanwhile, stopped 29 of 31 shots and made big save after big save to give New York a chance.
"I thought Igor was outstanding. He gave us a chance to win every night. We got outchanced in a lot of the games but he was outstanding. He was our best player all year long and again in this series," Gallant said.
"Shesterkin was unbelievable. He made some unbelievable saves to keep them in it, but I think I just felt kind of a calming presence because of the group," Stamkos said. "It was just one of those nights where whether it was the next shift after, whether I scored or someone else scored, it was just a feeling that we were going to get it done."


text:
Meet another patient
CrowdfundingMesoAbout UsLog InMeet another patient
Watsi
Success! Tal Tal from Thailand raised $1,500 to fund heart surgery.
$1,500 raised, $0 to go
Fully funded
Tal Tal's treatment was fully funded on August 22, 2018.
Tal Tal's story
Tal Tal's update
Tal Tal underwent heart surgery.
Since her surgery, Tal Tal feels better and is no longer tired. She can breathe properly and can walk longer distances.
"One day when I get a good job and can save money, I will help people as much as I can, who are suffering health issues like me," said Tal Tal.
Since her surgery, Tal Tal feels better and is no longer tired. She can breathe properly and can walk longer distances. "One day when I ...
Tal Tal is woman from Thailand. She lives with her family in Mae La refugee camp.
When Tal Tal was 13 years old, she was sick for a long time, and her mother brought her to a hospital. The doctor checked her heart and diagnosed her with congenital heart disease. She left her condition untreated until she was pregnant last year. A medic in Mae La camp took an X-ray and was worried that she might not be able to carry the pregnancy through. The medic referred her to Mae Sot Hospital (MSH), our medical partner's care center.
At MSH, Tal Tal received blood and urine tests, an echocardiogram, and oral medications for her heart condition. The doctor diagnosed her with atrial septal defect and told her that she should seek surgical treatment soon after giving birth. Recently, she delivered her baby safely at Mae La camp hospital. Now, she is scheduled for heart surgery on August 2. She needs help raising $1,500.
She says, "I feel stressed about this condition. Even though I have brothers and sisters, but they are unable to support my parents. And because of my condition now, I feel sad that I cannot support my parents too."
Tal Tal is woman from Thailand. She lives with her family in Mae La refugee camp. When Tal Tal was 13 years old, she was sick for a long...
Tal Tal's case was submitted by Bue Wah Say at Burma Children Medical Fund in Thailand.
Tal Tal's Timeline
PROFILE SUBMITTED
Tal Tal was submitted by Bue Wah Say, Project Officer at Burma Children Medical Fund, our medical partner in Thailand.
TREATMENT OCCURRED
Tal Tal received treatment at Lampang Hospital. Medical partners often provide care to patients accepted by Watsi before those patients are fully funded, operating under the guarantee that the cost of care will be paid for by donors.
PROFILE PUBLISHED
Tal Tal's profile was published to start raising funds.
Tal Tal's treatment was fully funded.
TREATMENT UPDATE
Tal Tal's treatment was successful. Read the update.
Share Tal Tal's story
Funded by 29 donors
ASD Closure
Cost Breakdown
On average, it costs $7,825 for Tal Tal's treatment
Subsidies fund $6,325 and Watsi raises the remaining $1,500
Hospital Fees
Impact on patient's life
Cultural or regional significance
What kinds of symptoms do patients experience before receiving treatment?
Patients may experience excessive sweating, extreme tiredness and fatigue, irregular heartbeat, rapid breathing or shortness of breath, chest pain, cyanosis (a blue tinge to the skin), clubbed fingernails, lightheadedness, or loss of consciousness.
What is the impact on patients' lives of living with these conditions?
Patients cannot do labor work—even doing household chores may tire them. Adults will be unable to care for their families, and children will be unable to play or attend school. As the condition progresses, patients may become unable to eat.
What cultural or regional factors affect the treatment of these conditions?
Burma has a long queue of congenital cardiac patients who need surgery. With only four fully trained cardiac surgeons in Burma, children with congenital heart defects may have extreme difficulty accessing treatment.
Risks and side-effects
Doctors may combine catheter and surgical procedures to repair complex congenital heart defects. If the defect cannot be fixed with a catheter, the patient will undergo an open heart surgery to close holes in the heart.
What is the impact of this treatment on the patient's life?
This surgery saves lives. Children will return to school, and adults will return to working and caring for their families.
What potential side effects or risks come with this treatment?
Potential side effects include bleeding, infection, fever, swelling, inflammation, arrhythmias, damage to surrounding organs, stroke, and death. Heart surgery is more likely to be life-threatening for patients who are very sick before the surgery.
How accessible is treatment in the area? What is the typical journey like for a patient to receive care?
Many of our medical partner's patients live in remote areas. They cannot afford or access treatment because it is only available in large cities.
What are the alternatives to this treatment?
There are no alternatives. If left untreated, this heart condition will become life-threatening for patients.
Meet another patient you can support
100% of your donation funds life-changing surgery.
Julius is a man from Kenya. A while ago, Julius developed a cataract in his right cataract, causing him blurry vision. A cataract occurs when the lens of the eye becomes opaque, blurring vision. He has difficulty seeing his children. Fortunately, Julius is scheduled to undergo cataract surgery at our medical partner's care center. Surgeons will remove and replace the blurred lens. After recovery, he will be able to see clearly. Now, he needs help to fund this $220 procedure. Julius says, "I want to regain my eyesight and continue providing for my wife."
23%funded
$52raised
$168to go
Angel is a child from Kenya. Last year, she fell on boiling cooking oil. She suffered extensive burns on her face, neck and right hand, spending six weeks in the hospital. She healed, but with contractures. Fortunately, our medical partner, African Mission Healthcare Foundation, is helping Angel receive treatment. On July 2, surgeons at their care center will perform a burn contracture release surgery to help her stretch her hand and use it freely. Now, she needs help to fund this $1,176 procedure. Angel says, "I want to be a teacher."
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Sarith is a Khmer cake seller from Cambodia. She has four sons and one daughter, and enjoys going to the pagoda in her free time. Two years ago, Sarith developed a cataract in each eye, causing her irritation, itchiness, tearing, and blurry vision. She has difficulty seeing things clearly, recognizing faces, and going anywhere outside. When Sarith learned about our medical partner, Children's Surgical Centre, she traveled for two hours seeking treatment. On June 5, doctors will perform a phacoemulsification cataract surgery and an intraocular lens implant in each eye. After recovery, she will be able to see clearly. Now, she needs help to fund this $398 procedure. Her son says, "I hope that my mother will be able to see clearly and that she can go back to taking care of herself."
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text:
require 'omniauth/timber/cantina/version'

module Omniauth
  module Timber
    module Cantina
      # Your code goes here...
    end
  end
end

redpajama_set_name: RedPajamaGithub


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text:
Up and Somewhat Close with King Khan on Netflix
The moment Khan appears on stage, looking very much his 53 years, but nonetheless dapper — in a charcoal black suit and an open white shirt — the theatre resonates with cheers from the audience that seems primarily desi.
Written by Ektaa Malik | New Delhi | Published: October 26, 2019 2:17:51 am
David Letterman with Shah Rukh Khan on the former's show which is aired on Netflix
My Next Guest with David Letterman and Shah Rukh Khan (Netflix)
Director: Michael Steed
IT'S TOUGH to say who was more charming on the latest episode of My Next Guest with David Letterman — the eponymous host or the guest. On My Next Guest Needs No Introduction with David Letterman, he has already had the ilk of Kanye West, Ellen Degeneres, and F1 champion Lewis Hamilton. He now tops it off with a stand alone offering where the daddy of late night TV interviews the "Bollywood megastar" Shah Rukh Khan. The one-hour show takes us into Khan's home, his kitchen and has Letterman trying his hand at cricket. All of it has him soaking in sheer love, admiration and near fanaticism that people of India have for Khan. The sea of people waiting to have a glimpse of Khan on Eid — an annual ritual for Khan and his fans — outside his sea-facing home Mannat; or the hordes desperate to get one touch, one handshake or a selfie on Bandstand with the King of Bollywood is routine news for us in the subcontinent, but for Letterman, who has interviewed the who's who of Hollywood and beyond, all of this is unimaginable. He is grappling with the enormity of Khan's stardom because honestly, sitting in a theatre, with an audience that has been screened and with the option of using canned laughter, interacting with Khan on his home turf is as real as it gets.
The show starts in a studio in LA. The moment Khan appears on stage, looking very much his 53 years, but nonetheless dapper — in a charcoal black suit and an open white shirt — the theatre resonates with cheers from the audience that seems primarily desi. We are taken through Khan's early days, his familial history, his debut on stage with the local Ramlila etc etc, and are cut back and forth to his home in Mumbai, where he is shown cooking Italian food, which he learnt to strengthen his bond with his children. Interspersed with more questions and conversation, we are given tiny slivers of information. Like how he was extremely possessive of his girlfriend Gauri before they got married; or that he is an extremely shy person; or the fact that he has to put up with the dating life of his children. He is also nocturnal by nature and sleeps at 5 am. We hear from Gauri as well, as she talks about what it is to be a megastar's wife, and to have kids who are studying in another continent. "We are concerned parents, not hysterical parents," clarifies Gauri. There are some sombre moments as well, when Khan speaks about losing his parents when he was all of 15, and how he views death as "extremely beautiful and alluring".
Most of the things that are revealed in the conversation are known by most fans of the actor. His dancing skills despite not being trained, his dimples and their effect on women. But what makes the episode worth a watch is the chemistry, wit and banter between Khan and Letterman. We all know Khan is witty, we have seen him on Koffee with Karan, but this time, he has outdone himself and has both the audience and Letterman eating out of his hand. There is a self-deprecatory strain, a humility, which is endearing. This can perhaps can be attributed to him ageing, or maybe because of repeated failures at the box office. "But I think I just happened to be the right person at the right place in the right scenario at the right time… Half through I realised that I am not half as talented as I think I am… If I can't do it with the skill and talent, then I'd better get into the hearts of people…" The jokes and one-liners don't seem rehearsed and the laughter of the audience is not canned. It can be a perfect watch for the whole family, maybe before the evening festivities for Diwali begin.
One last thought, why is there an over abundance of shots of crowded Mumbai? Of kitchsy calendar art, flower sellers and street food vendors? We get that Letterman and Co wish to establish the mis-en-scene of Mumbai, but this seems like an overkill. And why only of the crowds and alleys and bylanes? The cobbled streets of Mount Mary would have done well as well. All of it seems like an extension of Slumdog Millionaire. There is a sequence of Letterman playing cricket with an under-19 champion, and he is not bad. Perhaps that could be a separate episode.
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Brilliant idea for a thread.
Would be interested to hear the opinions on this article?
for me, its ok to give everyone a trophy or medal up until U10 or U12 MAX, any kid older than that wouldn't even want a medal for participation! most kids have a competitive edge built in, you have to harness that and develop it in the right way. a few dont have that competitive edge and it is very hard to change the mindset of those few.
I've been helping out with the U6's this year. It's about 40% coaching and 60% babysitting, but I really enjoyed every bit of it.
I was told if i wanted to coach next year that from U16 upwards you will have to have level 1 coaching badge in place...have any of you heard this?
"The policy, approved by GAA Central Council last June on the back of a recommendation from the Football Review Committee and a proposal from the National Games Development Committee, will require all Inter-County management teams in both hurling and football to contain an Award 2 coach from 2016. All Club management teams must contain an Award 1 Coach. From 2018 the Head Coach in both cases must be qualified at the appropriate level."
whether this will be enforced or not is another thing i suppose.
i have been trying since last December to get a coaching course and there has been nothing. they only run around this time of year, off season, October/November time. i just missed out on last years. if they are bringing in the above rule the GAA need to make coaching courses way more available to people.
Have to agree regarding the lack of coaching courses. Been helping out for 3 years now and will only get doing the foundation course next month!
But are they missing out on building up the life skills for dealing with failure? I don't think so. I know participation levels can be improved on and this is vitally important but I am not convinced that giving a kid something for just turning up is a good thing. Then suddenly you are promoting that just turning up is enough when that is not good enough in life.
I think it really boils down to how much is expected from a small pool of volunteers that end up coaching the kids. Normally too many kids and not enough coaches. Then when there is a game not enough places for every kids. I wonder if pooling all the kids together when at a blitz up until under 12s and picking teams based on dividing out the numbers rather than on the club would be a better approach so there would be no subs.
like i said, probably up to U10 would be acceptable to give a medal to all, at the end of the day, up to that age it IS all about turning up. getting them interested, getting them hooked.
as for the blitz idea, i wouldnt be for that, at that age the kids like the familiarity of their friends and it would knock them about throwing them in with strangers. i think there is already a rule in place that all kids get game time. not sure of what age that goes up to, U12 at least.
agree more coaches are needed. if you have big numbers you cant just lump them all together and throw in a ball, you would need 3/4 coaches running 3/4 mini games to ensure the kids get plenty of time on the ball. ive seen it before where you have 20/25 kids all playing in one game, the ball stays up one end of the pitch pinging around for 5 mins when the kids at the other end are leaning on the hurls chatting and picking their noses!!
young kids up to U12 must be kept entertained and busy!
U16 is a tough group to manage, they're not quite adults but they like to think they are!
then split this into 3 zones (DEF/MF/FWD) of 15 yards each.
Getting the kids used to the idea of staying in their zone was pretty easy, turn over possession every time they strayed into the next zone and they soon realise their boundary. Using zones is also an easy way to switch the kids into different positions. Every kid gets plenty of time on the ball during the game as well.
Like Declan, I'm a coach in a football club - have coached for 10 years and am taking U17s this year. I've a UEFA Youth Cert which qualifies me to coach up to U18s. I always thought I'd have no interest in coaching at senior/adult level, and Declan's comments would appear to back up that thinking. I understand that I'm moving back to some sort of 'coach the coaches' role from next season as the club tries to implement a football development plan. As Dinny says, ego is the main issue we face on a daily basis - I don't think I'm looking forward to a role where I am to be 'instructing' those who already know everything.
I was aware of this in go-games, fantastic initiative but sad to hear coaches manipulating it, again ego is hard to contain.
I have a simple rule for all my teams if you are in the squad and are fit you get substantial game time and these are 15 year old up to 20 year old young men, it helps it rugby though that you can make 12 inter-changes, roll on roll off. I have lost games because of it but I have never lost a player because of it.
Also I had a young player who had to give up rugby and GAA because he signed schoolboy forms for a soccer club in Dublin and his "contract" forbid him from playing other sports! Is this a common occurrence?
That happened me. I was told I would have to give up the GAA if I wanted to play soccer in Athlone. I was on the minor panel at the time, so I turned them down.
As regards the coaches thing, my position on this in our club is that if we are sitting in the pub congratulating ourselves as coaches because we won an U14 championship, but we only did so because we had a couple of big strong lads and everything went through them, and ignored all our 'weaker players', then we have failed as coaches, not succeeded. In 4 years time the big lads will be the same size as everyone else, and we'll have lost the so called weaker players.
I would think that a contract with an U-16 wouldn't be enforceable. Anyone with a legal background able to confirm?
As for coaching, my young lad's club asked me to train as a coach, but work interfered unfortunately so I couldn't make it. The club probably won't run another course for a while. Is there anywhere else I can go to get the relevant qualifications?
I think most of the 'big' football clubs don't want the distractions of other sports from U16 onward. In fact, actually (in North Dublin anyway) the GAA switch U15/16 games to Sundays only for that year - have always interpreted that as a ploy to make kids decide. It fails miserably in that (in our parish anyway) there's neither a football team or a gaelic football team at U15 for that year. And it all falls back into place for U16, as if nothing had happened.
I did the foundation course 1/2 was theory and 1/2 was drills with football. Thought it was a waste of time to be honest. Jobs for the boys type thing.Think any future coach should be put with experienced coach for 3 weeks, after that sink or swim. Have to say I really enjoyed year, worked with U-8's, parents were great too. We had 40 girls and boys between 5 coaches. We did a 10 min warm up with footballs. 30 mins of drills (picking up, fist pass, foot pass, tackling, solo, catch etc. ) Finished up with 25 minute condition game, broke into 2 groups based on standard.
Next year we hope to develop spacial awareness and picking out a pass among the kids, however at that age group don't think it may be possible. The go games are great, as long as the competing teams are not unbalanced.
Super thread by the way.
Johan Forsberg is a professional Ice Hockey player at Luleå Hockey. In October 2015 he posted a stunning open letter to ALL young Swedish Ice Hockey players on his Facebook page. This was a response to the ongoing, often polarised debate in Sweden with regard to early talent identification, early selection and elite programs. This emotional message is relevant to all youth sports. I urge you to share it with as many people as possible. This is a must read for all children, parents, coaches, Governing Bodies and club stakeholders.
I was very bad at skating, among other things and I have not been much better since.
I threw the equipment in a corner at home in the garage and felt no joy for my friends who got a place in the elite camp.
Johan Forsberg – Luleå Hockey.
Very Good. Istvan Balyi, an authority on long term athlete development, spoke to our club as we formulated our coaching and development plan. He gave a very similar anecdote regarding Ice Hockey in Canada. They are apparently losing players by the thousand every year because of their emphasis on the 'elite' development, from a very young age, and he pointed out that there are many many reasons, psychological and physiological, why a child may not have the same technical proficiency or athletic ability to some of his peers, and there is no reason to sideline them and ignore them. The classic 'late developers'.
I agree with that. I'm not sure about development squads and never have been. Maybe @ Under 17 in preparation for Minor the following year but outside of that it's just too much given the fact that lads are probably playing on School teams as well. Add to that if you're good enough you're maybe playing on 2/3 school teams and maybe you're good at Soccer/Rugby/Hurling as well then it just gets ridiculous!!


Joseph John Cole, better known as Joe Cole, was born on 8th November 1981, in Islington, London.
He was an attacking midfielder for England.
Joe Cole worked his way up through the West Ham youth academy, and from a very young age was regarded as one of the hottest new talents in English football.
He has drawn comparisons with Paul Gascoigne as he plays with flair in a similar position.
Joe Cole progressed through the Hammers ranks very quickly and made his first team debut at the age of 17. However, after West Ham's manager, Harry Redknapp left the club, Coles form declined in spite of his incredible natural talent.
Joe Cole's target was to become a regular in the England first team and to help further his chances, he moved to Chelsea in 2003, for 7m, as one of the first signings under the Roman Abramovich reign.
Initially Joe Cole failed to shine at Stamford Bridge due to competition from players such as Damien Duff and Arjen Robben. However, when Claudio Ranieri was sacked, and Jose Mourinho came to Chelsea, Joe Cole's form improved massively and he started playing in the team more often.
Joe Cole was a squad member at Euro 2004 but didn't actually play. Some consider him to be the solution to England's 'left wing problem' and since 2004 he has continued to gain international caps.
He continued to shine. Joe Cole's many quality performances included England's match in the World Cup 2006 against Sweden, where he was rightly named FIFA Man of the Match.
Joe Cole came fourth in The Independent's list of Britain's happiest people.
Joe Cole was selected for the PFA Premiership Team of the Year 2006.
On 20 June 2009, Joe Cole married Carly Zucker.
On 18 March 2010, Carly gave birth to a baby girl.
In June 2010, Chelsea confirmed that Joe Cole, who was at the time in England's World Cup squad, would leave the club on a free transfer in the summer.
In July 2010, Joe Cole signed for Liverpool on a four-year contract.
In August 2011, he completed a loan move to Lille in France.


text:
Maduro Virtually Unopposed in April Elections in Venezuela
February 22, 2018 February 22, 2018 Circles Robinson 0 Comments
By Nestor Rojas Mavares (dpa)
Nicolás Maduro has said he is sure "the people love me" his guarantee to lead the country through 2025. Photo: telesurtv.net
HAVANA TIMES – The main Venezuelan opposition announced on Wednesday that it will not participate in the snap presidential elections of April 22, because it considers the vote a show by President Nicolas Maduro, who will now run virtually unopposed for re-election until 2025.
"Do not count on the Mesa de Unidad Democrática (MUD) coalition nor the Venezuelan people to endorse what until now is only a fraudulent and illegitimate simulation of a presidential election," said the grouping that brings together the main opposition parties in the country.
The alliance said in a statement that it is ready to participate in clean, transparent elections with international observation.
The opposition position comes as the country slips deeper by the day into severe economic recession with shortages of basic foods and medicines, along with hyperinflation and a lack of cash currency in circulation.
MUD spokesperson Ángel Oropeza, read the statement which indicates that the goal of the alliance is to achieve the democratic conditions that would allow fair elections.
"We have agreed by consensus to continue demanding free elections to come out of what is pummeling our people," he said.
The opposition leader said that if the government complies with the laws and electoral conditions, they will participate in elections, first called by the Constituent Assembly, totally dominated by Maduro and associates, and then set by the National Electoral Council (CNE).
In an immediate reaction, Maduro said that on April 22 there will be elections with or without opposition and he replied to the MUD saying that he will propose to the Constituent Assembly, totally dominated by his supporters, to advance the legislative elections of 2020 and those of the regional councils, for the same balloting on April 22 along with the presidential vote.
"Come rain, thunder or lightening, there will be elections here, with MUD or without MUD," he said, calling the opposition coalition "arrogant."
In addition, he said he is confident that some opposition candidates will be registered outside the MUD for the presidential elections. "Here there will be elections for president, deputies and regional councils," he said.
At the same time, Maduro welcomed the CNE's invitation for a United Nations delegation to participate as an observer in the elections and that the former president of the Spanish Government, Jose Luis Rodriguez Zapatero, will lead it.
For several days, the opposition was discussing whether to participate in the decision in Maduro's. Despite the alliance's withdrawal, pre-candidate Henri Falcón, of the small Progressive Alliance party, said he will keep his candidacy. Another opponent, Claudio Fermín, without partisan support in the MUD, also presented his name for the presidential elections. (Editors Note: on Thursday Fermín also withdrew his candidacy)
The MUD called the April 22 elections premature and without proper conditions. "(They are) a show of the Government to pretend a legitimacy that it doesn't have, in the midst of the agony and suffering of the Venezuelans," said Ángel Oropez.
"We are calling on Venezuelans to get off the fence…, realizing that these are not elections. Our objective is to achieve real elections, the Constitution demands it and we will direct our struggle towards that goal," he added.
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