text:
Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing
Ki Mo Jang, Hong Chul Lim, Woon Yong Jung, Sang Won Moon, Joon Ho Wang
Purpose To investigate whether non-autologous transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) could be integrated safely at the bone-tendon junction without immune rejection and could enhance bone-tendon healing effectively during anterior cruciate ligament (ACL) reconstruction in an animal model. Methods ACL reconstructions using hamstring tendons were performed in 30 adult rabbits. The bone tunnels were treated with hUCB-MSCs or were untreated. The specimens were harvested at 4, 8, and 12 weeks. We performed a gross examination of the knee joint; a histologic assessment using H&E staining, as well as immunohistochemical staining, for type II collagen; and an evaluation of bone tunnel widening using micro-computed tomography. Results No evidence of immune rejection was detected. Tendon-bone healing through Sharpey-like fibers was noticed around tendon grafts at 12 weeks in the control group. A smooth transition from bone to tendon through broad fibrocartilage formation was identified in the treatment group, and the interface zone showed abundant type II collagen production on immunohistochemical staining. Histologic scores for bone-tendon healing were significantly higher in the treatment group at all time points (P <.001). Micro-computed tomography at 12 weeks showed a significantly smaller tibial (P =.029) and femoral (P =.033) bone tunnel enlargement in the treated group than in the control group. Conclusions Non-autologous transplantation of hUCB-MSCs was applied in ACL reconstruction without early immune rejection. There was enhanced tendon-bone healing through broad fibrocartilage formation with higher histologic scores and decreased femoral and tibial tunnel widening compared with the control group (79.2% and 80%, respectively, of the control group tunnel area at 12 weeks). Clinical Relevance Non-autologous transplantation of hUCB-MSCs has therapeutic potential in promoting tendon-to-bone healing after ACL reconstruction. Further study in the human model is warranted.
Arthroscopy - Journal of Arthroscopic and Related Surgery
https://doi.org/10.1016/j.arthro.2015.02.023
Published - 2015 Aug 1
10.1016/j.arthro.2015.02.023
Dive into the research topics of 'Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing'. Together they form a unique fingerprint.
Anterior Cruciate Ligament Reconstruction Medicine & Life Sciences 100%
Fetal Blood Medicine & Life Sciences 84%
Tendons Medicine & Life Sciences 79%
Mesenchymal Stem Cells Medicine & Life Sciences 76%
Rabbits Medicine & Life Sciences 60%
Bone and Bones Medicine & Life Sciences 50%
Jang, K. M., Lim, H. C., Jung, W. Y., Moon, S. W., & Wang, J. H. (2015). Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing. Arthroscopy - Journal of Arthroscopic and Related Surgery, 31(8), 1530-1539. https://doi.org/10.1016/j.arthro.2015.02.023
Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model : New strategy to enhance tendon graft healing. / Jang, Ki Mo; Lim, Hong Chul; Jung, Woon Yong et al.
In: Arthroscopy - Journal of Arthroscopic and Related Surgery, Vol. 31, No. 8, 01.08.2015, p. 1530-1539.
Jang, KM, Lim, HC, Jung, WY, Moon, SW & Wang, JH 2015, 'Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing', Arthroscopy - Journal of Arthroscopic and Related Surgery, vol. 31, no. 8, pp. 1530-1539. https://doi.org/10.1016/j.arthro.2015.02.023
Jang KM, Lim HC, Jung WY, Moon SW, Wang JH. Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing. Arthroscopy - Journal of Arthroscopic and Related Surgery. 2015 Aug 1;31(8):1530-1539. doi: 10.1016/j.arthro.2015.02.023
Jang, Ki Mo ; Lim, Hong Chul ; Jung, Woon Yong et al. / Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model : New strategy to enhance tendon graft healing. In: Arthroscopy - Journal of Arthroscopic and Related Surgery. 2015 ; Vol. 31, No. 8. pp. 1530-1539.
@article{86604f62a8ff495bb9fc6b89b3033fee,
title = "Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model: New strategy to enhance tendon graft healing",
abstract = "Purpose To investigate whether non-autologous transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) could be integrated safely at the bone-tendon junction without immune rejection and could enhance bone-tendon healing effectively during anterior cruciate ligament (ACL) reconstruction in an animal model. Methods ACL reconstructions using hamstring tendons were performed in 30 adult rabbits. The bone tunnels were treated with hUCB-MSCs or were untreated. The specimens were harvested at 4, 8, and 12 weeks. We performed a gross examination of the knee joint; a histologic assessment using H&E staining, as well as immunohistochemical staining, for type II collagen; and an evaluation of bone tunnel widening using micro-computed tomography. Results No evidence of immune rejection was detected. Tendon-bone healing through Sharpey-like fibers was noticed around tendon grafts at 12 weeks in the control group. A smooth transition from bone to tendon through broad fibrocartilage formation was identified in the treatment group, and the interface zone showed abundant type II collagen production on immunohistochemical staining. Histologic scores for bone-tendon healing were significantly higher in the treatment group at all time points (P <.001). Micro-computed tomography at 12 weeks showed a significantly smaller tibial (P =.029) and femoral (P =.033) bone tunnel enlargement in the treated group than in the control group. Conclusions Non-autologous transplantation of hUCB-MSCs was applied in ACL reconstruction without early immune rejection. There was enhanced tendon-bone healing through broad fibrocartilage formation with higher histologic scores and decreased femoral and tibial tunnel widening compared with the control group (79.2% and 80%, respectively, of the control group tunnel area at 12 weeks). Clinical Relevance Non-autologous transplantation of hUCB-MSCs has therapeutic potential in promoting tendon-to-bone healing after ACL reconstruction. Further study in the human model is warranted.",
author = "Jang, {Ki Mo} and Lim, {Hong Chul} and Jung, {Woon Yong} and Moon, {Sang Won} and Wang, {Joon Ho}",
note = "Funding Information: The authors report the following potential conflict of interest or source of funding: Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2012044586 ). Publisher Copyright: {\textcopyright} 2015 Arthroscopy Association of North America.",
doi = "10.1016/j.arthro.2015.02.023",
journal = "Arthroscopy - Journal of Arthroscopic and Related Surgery",
T1 - Efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells in anterior cruciate ligament reconstruction of a rabbit model
T2 - New strategy to enhance tendon graft healing
AU - Jang, Ki Mo
AU - Lim, Hong Chul
AU - Jung, Woon Yong
AU - Moon, Sang Won
AU - Wang, Joon Ho
N1 - Funding Information: The authors report the following potential conflict of interest or source of funding: Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2012044586 ). Publisher Copyright: © 2015 Arthroscopy Association of North America.
N2 - Purpose To investigate whether non-autologous transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) could be integrated safely at the bone-tendon junction without immune rejection and could enhance bone-tendon healing effectively during anterior cruciate ligament (ACL) reconstruction in an animal model. Methods ACL reconstructions using hamstring tendons were performed in 30 adult rabbits. The bone tunnels were treated with hUCB-MSCs or were untreated. The specimens were harvested at 4, 8, and 12 weeks. We performed a gross examination of the knee joint; a histologic assessment using H&E staining, as well as immunohistochemical staining, for type II collagen; and an evaluation of bone tunnel widening using micro-computed tomography. Results No evidence of immune rejection was detected. Tendon-bone healing through Sharpey-like fibers was noticed around tendon grafts at 12 weeks in the control group. A smooth transition from bone to tendon through broad fibrocartilage formation was identified in the treatment group, and the interface zone showed abundant type II collagen production on immunohistochemical staining. Histologic scores for bone-tendon healing were significantly higher in the treatment group at all time points (P <.001). Micro-computed tomography at 12 weeks showed a significantly smaller tibial (P =.029) and femoral (P =.033) bone tunnel enlargement in the treated group than in the control group. Conclusions Non-autologous transplantation of hUCB-MSCs was applied in ACL reconstruction without early immune rejection. There was enhanced tendon-bone healing through broad fibrocartilage formation with higher histologic scores and decreased femoral and tibial tunnel widening compared with the control group (79.2% and 80%, respectively, of the control group tunnel area at 12 weeks). Clinical Relevance Non-autologous transplantation of hUCB-MSCs has therapeutic potential in promoting tendon-to-bone healing after ACL reconstruction. Further study in the human model is warranted.
AB - Purpose To investigate whether non-autologous transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) could be integrated safely at the bone-tendon junction without immune rejection and could enhance bone-tendon healing effectively during anterior cruciate ligament (ACL) reconstruction in an animal model. Methods ACL reconstructions using hamstring tendons were performed in 30 adult rabbits. The bone tunnels were treated with hUCB-MSCs or were untreated. The specimens were harvested at 4, 8, and 12 weeks. We performed a gross examination of the knee joint; a histologic assessment using H&E staining, as well as immunohistochemical staining, for type II collagen; and an evaluation of bone tunnel widening using micro-computed tomography. Results No evidence of immune rejection was detected. Tendon-bone healing through Sharpey-like fibers was noticed around tendon grafts at 12 weeks in the control group. A smooth transition from bone to tendon through broad fibrocartilage formation was identified in the treatment group, and the interface zone showed abundant type II collagen production on immunohistochemical staining. Histologic scores for bone-tendon healing were significantly higher in the treatment group at all time points (P <.001). Micro-computed tomography at 12 weeks showed a significantly smaller tibial (P =.029) and femoral (P =.033) bone tunnel enlargement in the treated group than in the control group. Conclusions Non-autologous transplantation of hUCB-MSCs was applied in ACL reconstruction without early immune rejection. There was enhanced tendon-bone healing through broad fibrocartilage formation with higher histologic scores and decreased femoral and tibial tunnel widening compared with the control group (79.2% and 80%, respectively, of the control group tunnel area at 12 weeks). Clinical Relevance Non-autologous transplantation of hUCB-MSCs has therapeutic potential in promoting tendon-to-bone healing after ACL reconstruction. Further study in the human model is warranted.
U2 - 10.1016/j.arthro.2015.02.023
DO - 10.1016/j.arthro.2015.02.023
JO - Arthroscopy - Journal of Arthroscopic and Related Surgery
JF - Arthroscopy - Journal of Arthroscopic and Related Surgery


The design process for aircraft is one of the main digital disruptions in the aerospace sector. The CH-53K King Stallion helicopter that Sikorsky is developing for the U.S. Marine Corps is the Lockheed Martin subsidiary's first production aircraft built with a completely digital, paperless design, said Andreas Bernhard, the helicopter's chief engineer at Sikorsky. Looking ahead to the 2020s, Bernhard predicted, "our most profitable product is no longer going to be the Black Hawk, but the CH-53K." New technologies on the CH-53K also include composite rotor blades that he said "generate enough lift to carry an empty Black Hawk," a transmission with improved power density than previous generation Sikorsky helicopters, and digital engine controls in the cockpit.


Similar to Windows tracert, it tries to find the successive hops in the path by sending ICMP echo packets with increasing values of TTL field.
Contrary to Cisco IOS and most Unix systems that send UDP packets to high-numbered ports, tracert uses ICMP echo packets.
For each router found in the path (= source IP address in the ICMP TTL exceeded message), mturoute tries to find path MTU to that hop using the same algorithm as in the ping mode.
During the bisecting phase, the mturoute does not print all the messages it prints in the ping mode, but just the cryptic signs (+/-/u/.) indicating its progress. Their meaning is documented in the previous post.
After the path MTU to the router under investigation is measured, mturoute reports the router's IP address and path MTU.
The second hop in the printout has an inbound access-list that blocks incoming ICMP packets. The mturoute thus reports receiving ICMP unreachable ('u') as well as ping timeouts ('.') as not every incoming packet is replied to due to ICMP rate-limiting in Cisco IOS.


text:
Georgia State's Inaugural FBS Football Schedule Announced
ATLANTA (March 1, 2013) Georgia State's 2013 football schedule for the Panthers' inaugural season in the Football Bowl Subdivision and the Sun Belt Conference and first year under head coach Trent Miles is complete with the announcement of the seven-game Sun Belt schedule by the conference office.
The 12-game slate includes seven home games at the Georgia Dome and five road games.
For GSU's inaugural season in the Sun Belt, the Panthers will host conference foes Troy, South Alabama, Western Kentucky and Louisiana-Lafayette at the Georgia Dome and will travel to Arkansas State, Louisiana Monroe and Texas State.
As previously announced, Georgia State's non-conference schedule features home games against Samford, Chattanooga and Jacksonville State as well as road trips to West Virginia and defending national champion Alabama.
"We are excited to begin this next chapter in Georgia State football with a very attractive and challenging schedule," said Director of Athletics Cheryl L. Levick. "We are especially pleased that our home schedule features regional opponents Troy, South Alabama, Western Kentucky, Samford, Chattanooga and Jacksonville State, all within driving distance of the Georgia Dome. In addition, we have amazing opportunities for our fans to travel to road games at Alabama and West Virginia.
"Coach Miles has received such tremendous support from the Georgia State family and the Atlanta community, and we look forward to helping him build this program," Levick added.
The Panthers will kick off the 2013 season and the Trent Miles era by hosting Samford in the season opener at the Georgia Dome. The game will be played on Thursday, Aug. 29 or Friday, Aug. 30, pending the announcement of the Atlanta Falcons' preseason schedule.
The Panthers host a second straight home game to start the season as Chattanooga visits the Georgia Dome Sept. 7, followed by the Sept. 14 road trip to West Virginia. After hosting Jacksonville State on Sept. 21, the Panthers have an open date before travelling to Alabama on Oct. 5.
The first Sun Belt Conference game in Georgia State history will take place on Oct. 12 when the Panthers host Troy at the Georgia Dome. One week later, GSU's first Sun Belt road game will take place at Texas State in San Marcos, Texas on Oct. 19.
The Sun Belt slate continues with home dates against Western Kentucky (Nov. 2), Louisiana-Lafayette (Nov. 16) and South Alabama (Nov. 30) and road tests at Louisiana Monroe (Oct. 26) and Arkansas State (Nov. 23).
The Panthers will play six bowl teams from 2012 in Alabama, West Virginia, Arkansas State, Louisiana Monroe, Louisiana-Lafayette and Western Kentucky.
Season tickets are on sale now for as low as $70. Renewal packets have been mailed to all 2012 season ticket holders, who can complete the renewal process by mail, on-line at GeorgiaStateSports.com or by calling the Panther Sales Center at 866-GA-STATE. Those interested in purchasing season tickets for the first time should call the Panther Sales Center at 866-GA-STATE.
Season tickets in priority sections range from $125 to $350, which includes a donation to the Panther Athletic Club (PAC). Tickets in the ultra-premium Huddle section at the 50-yard line are available for $2,500 per pair, including the PAC donation.
Sideline reserved season tickets in non-priority sections are priced at $85, while general admission season tickets are available for just $70.
Season tickets in the popular Family Section, sponsored by Willy's, are priced at $200, which includes two adult tickets and two youth tickets. The Family Section also provides direct access to Pounce Town, the interactive area for children featuring inflatables, games, music, autographs and kid-friendly concessions.
Georgia State faculty and staff receive a 20 percent discount on season ticket prices.
With the addition of a seventh home game to this year's schedule, Georgia State Athletics is offering special pricing for all fans who renew or purchase their season tickets by April 1. After April 1, prices in all reserved sections will increase to reflect the additional game.
2013 GEORGIA STATE FOOTBALL SCHEDULE
Subject to Change * Times TBA * Home Games at Georgia Dome
Aug 29 or 30 SAMFORD
Sept. 7 CHATTANOOGA
Sept. 14 at West Virginia
Sept. 21 JACKSONVILLE STATE
Oct. 5 at Alabama
Oct. 12 TROY
Oct. 19 at Texas State
Oct. 26 at Louisiana Monroe
Nov. 2 WESTERN KENTUCKY
Nov. 16 LOUISIANA LAFAYETTE
Nov. 23 at Arkansas State
Nov. 30 SOUTH ALABAMA

redpajama_set_name: RedPajamaCommonCrawl


text:
Qashqai Crossover Becomes Nissan's Highest Volume Car Ever In Europe
News, Nissan, Top News
Nissan has now built more Qashqais than any other car in its three decades of manufacturing in Europe. Production of the award-winning crossover – at the Sunderland factory in the UK – has recently surpassed the previous highest single-name manufacturing total. That record was 2,368,704 units, previously held by another of Nissan's European icons, the Micra supermini.
The Qashqai reached 2,368,705 units to overtake the Micra in less than 10 years. Nissan's Sunderland plant continues to produce around 1,200 Qashqais every day, and by the end of February 2016 the total stood at 2,398,134 units. No other car in the history of the UK car industry has gone beyond 2m units in such a short period of time.
Colin Lawther, Nissan's Senior Vice President for Manufacturing, Purchasing and Supply Chain Management in Europe, said: "The Qashqai created an entirely new segment when it was first launched and continues to set the standard in crossovers, supporting a record period of growth for Nissan in Europe.
"The Micra is an iconic model for Nissan in Europe, made for 18 years in our Sunderland plant. To overtake it in half the time shows just how quickly our European customers have taken Qashqai to their hearts."
Styled and engineered for European customers in Nissan's UK-based design and technical centres, the Qashqai is Nissan's top-selling car in Europe. It's also the best-selling crossover in Europe, requiring round-the-clock production since 2010.
Following a string of awards, demand for the Nissan Qashqai shows no sign of slowing down. In September 2015 the second-generation Qashqai became the fastest ever UK-built vehicle to smash the half-million production mark. Today, a new Qashqai is built every 62 seconds, or 58 per hour, at the Sunderland site.
The Nissan Qashqai will also become a pioneer of Autonomous Driving. At the Geneva Motor Show earlier this month, Nissan has announced that, from next year, the Qashqai will be Nissan's first vehicle in Europe to feature 'Piloted Drive' technology. In the first instance, this will allow the car to drive autonomously and safely in a single lane in heavy traffic conditions on highways. Other developments will follow.
Lawther added: "Qashqai has propelled our Sunderland plant to become the biggest UK car plant of all time and taken Nissan sales in Europe to record levels. With autonomous technologies on the way from next year, Qashqai is helping Nissan raise the bar even higher for crossovers."
Later in 2016, Nissan will be celebrating the 30th anniversary of the Sunderland facility, which now manufactures the Qashqai and Juke crossovers, the all-electric LEAF, the Note hatchback and the new Infiniti Q30 premium compact car.


text:
Juan Montoya gets his first win at a somber Monza
By NIGEL ROEBUCK
In the end, it was a good Italian Grand Prix. A far better one, given its edgy and acrimonious build-up, than we had any right to expect. It was only a matter of time before the cards fell for Juan Montoya. At Monza he started from pole position, his third in four races, and went on to win his first grand prix superbly.
This was no easy win. In both stints Montoya was hampered by blistered rear tires. Had Rubens Barrichello—Ferrari's star this weekend—not lost time in a botched pit stop, the tofisi might have gone home happy. Barrichello's car ran perfectly throughout, five seconds adrift of the Williams-BMW at the end.
Montoya and Barrichello were the main protagonists. The Schumacher brothers, third and fourth, never looked like potential winners. Michael, in particular had a colorless afternoon, his driving a mirror of his mood. He didn't want to be at Monza and it showed.
Excellent strategy helped Pedro de la Rosa to a fine fifth place, only the third points finish for Jaguar this season, and Jacques Villeneuve's hard-driven BAR-Honda was sixth.It was no fun being at Monza, traditionally a place of exuberance, under the circumstances. For obvious reasons the atmosphere in the paddock was somber and the conversations had nothing to do with motor racing. At the insistence of Philip Morris all the Marlboro identification had been removed from the Ferraris, the team's other sponsors followed suit. Apart from a black nose therefore, the cars were in plain Italian Racing Red for the first time in more than 30 years. They looked starkly beautiful. Some thought it was a good thing to do, others not. Perhaps the only real certainty in a situation like this is there are no right decisions.
There were those among the drivers, notably Ralf Schumacher, who felt the Italian Grand Prix should have been postponed. Michael seemed almost like a man in a trance. At a press conference on Thursday afternoon, he answered questions like an automaton; it was the face of a man with more important things on his mind.
There was some indication it was affecting his driving a touch. In qualifying, he was only third fastest, behind his teammate Barrichello (for the first time this year), and Montoya.
"Nothing wrong with the car," Michael shrugged. "The balance was good, and so were my sector times, I just didn't get it together. I'm more optimistic for the race."On Saturday afternoon, not long after a desultory post-qualifying press conference, came the appalling news of Alex Zanardi's accident at the Lausitzring, inevitably heightening the tension in the Monza paddock to a point that at times seemed almost hysterical. Montoya was probably the calmest man in the place. In terms of pure driving, Montoya said, Monza wasn't as satisfying as Spa but this latest pole gave him considerable pleasure. "To beat the Ferraris in Italy is quite special," he murmured. "We struggled a bit yesterday," he went on, "but we made a lot of changes, and the car was really good for qualifying." And how was the race set-up? "Oh, fine. The car doesn't change much from qualifying to race."
In the race morning warmup, Michael Schumacher was fastest, followed by David Coulthard, Montoya and Barrichello, but if this cheered Michael there was little evidence of it. Through the morning there was a great deal of to-ing and fro-ing among the motorhomes, lots of conversation between the drivers, and soon word emerged, the topic under discussion was The First Lap.
Twelve months ago there was a huge accident at the opening lap's second corner, which sadly cost the life of a fire marshal. According to Barrichello, the Grand Prix Drivers Association asked for a number of changes to be made, but, "As far as I know, the changes didn't go through."
That sounded strange: A year had passed since the accident, during which time most of the teams had tested at Monza more than once, and, that being so, it was not immediately obvious why, on race morning, the matter of first lap safety was suddenly such an overwhelming concern.
Not that anyone was making light of the drivers' fears, but as the morning wore on one had the impression of a sort of mad momentum building. There was talk of starting behind the Safety Car (the powers-that-be dismissed that), then of a drivers' private agreement: There should be no overtaking on the first lap at either the first or second chicanes.
It was becoming surreal. Was this a grand prix, with 22 of the best drivers in the world, or not? In the end, the madcap idea was dropped, only because unanimity among the drivers proved impossible to achieve: Jacques Villeneuve didn't want to hear it. "I'm here to go racing," he said simply, and quite right, too.
As two o'clock approached, everyone was intensely nervous. With so much tension in the air who knew what might happen on the all-important first lap? Once the warm-up laps had been completed, Michael Schumacher could be seen going from driver to driver on the grid, clearly imparting a message to each. On came the five lights, then off, and Montoya made a perfect start leading the pack towards the first turn, where Jenson Button, whose getaway was electrifying, succeeded in punting Jarno Trulli's Jordan into instant retirement. There was more to come. The Schumachers, having spearheaded the let's-all-be-gentle movement, proceeded through the first Lesmo side-by-side, then Michael put two wheels on the grass to pass his brother.
Once everything settled down Montoya was in front, followed by Barrichello, Michael and Ralf, Coulthard, the Jaguars of de la Rosa and Eddie Irvine. Jos Verstappen, Kimi Raikkonen and Jean Alesi, who passed four cars on the opening lap.
After his altercation with Trulli, Button dashed in for a new nose at the end of lap one, but by lap five his Benetton-Renault had smokily expired, and not long afterwards Coulthard's McLaren-Mercedes followed suit.
The weekend proved an utter debacle for McLaren. Its cars were not only uncompetitive, but also frail. Mika Hakkinen, ushered by the Button/Trulli contretemps into the escape road at the first corner, ran 10th or thereabouts until lap 19 when his car began progressively to lose all its gears. Not McLaren's proudest day.
Montoya continued to lead, but Barrichello was hard after him, and the gap was never more than a second. On lap nine there was a change of position at the second chicane."I got a blister on a rear tire," said Montoya, "and started sliding under braking. Finally I made a mistake, and Rubens passed me. Afterwards it took me a couple of laps to get back in the groove. I learned to drive the car with that amount of oversteer, and by the end of the run I was actually fairly quick."
Once Barrichello had gone by, he quickly pulled out a substantial lead, and at this point Montoya came under pressure from M. Schumacher, who proved rather less resolute than his teammate. Perhaps the most anxious moment in this battle came on lap 15 when Alex Yoong, making his debut for Minardi, spun at the exit of the second Lesmo, and finished up broadside, half on the track and half off. Montoya and Schumacher missed him, but it made you catch your breath.
By now Barrichello, driving beautifully, was more than seven seconds ahead of Montoya and M. Schumacher, who continued to fight over second place, and were themselves 12 seconds clear of Ralf Schumacher, who circulated in a lonely fourth place, well ahead of Verstappen and then Alesi. The rate at which Barrichello left Montoya behind indicated different strategies were in play here, with Ferrari planning two stops and Williams-BMW on one: such proved to be the case.
At the end of lap 18, M. Schumacher, who had failed to get ahead of Montoya, came in for his first stop, and got on his way again after 10.4 seconds, rejoining in fourth place, behind his brother.
Lap 19—the important one, for Barrichello was in, necessarily surrendering the lead once more to Montoya. Had the stop gone well, Ross Brawn's plan to beat Williams might well have worked, but in fact the Ferrari was stationary for more than 16 seconds."Unfortunately," said Jean Todt, "a problem with the re-setting of the refuelling rig cost Rubens around seven seconds, probably enough to deprive him of victory." In fact it looked more like the Ferrari crew had goofed, initially using the same rig as used for Schumacher's stop, then switching to the one intended for Barrichello. Whatever, the delay put Barrichello on the back foot for the balance of the race. He rejoined third, five seconds behind Ralf Schumacher, six ahead of Michael.
Now it was the two Williams-BMWs, on a one-stop strategy, ahead of the two Ferraris. Alesi, fifth, and Raikkonen, sixth, both came in on lap 22 (rejoining in seventh and 13th places, respectively), at which point de la Rosa and Villeneuve moved up into the remaining point-scoring positions they would hold to the flag.
Montoya looked all set at more than 20 seconds ahead. Although oversteering, thanks to rear tire blisters, he was at no disadvantage to his teammate, for Ralf was similarly troubled. As for the Ferraris, they seemed able to make little impression. On lap 28 Montoya came in for fuel and tires (11.9 seconds), and the mechanics took the opportunity to make a front wing adjustment.
Montoya's stop put his teammate into the lead, and, once there, Ralf finally got with it, setting a new fastest lap, and increasing his advantage over Barrichello. Montoya had rejoined in third place, narrowly ahead of Michael Schumacher, and for a few laps there was relative stalemate.
Lap 35: Ralf in. Having run an initial stint seven laps longer than Montoya, at 7.9 seconds his stop was quicker, but again there was front wing adjustment. Now we had Barrichello in the lead once more, followed by Montoya, M.Schumacher, R. Schumacher, and then de la Rosa and Villeneuve, who had by this time made their stops and retained their positions through them.
Raikkonen, seventh, was now the only other driver unlapped, for Alesi's great charge, sadly, had been interrupted by an unexpectedly early second stop for a flat-spotted tire.
All things being equal, it was clear Montoya was in good shape to win it. He was losing ground to Barrichello, who was only 13 or 14 seconds ahead, and would need to stop again. Montoya would not. On lap 40 Michael Schumacher made his second stop (6.7 seconds), and next time around Barrichello came in. In the grandstands, they looked on the scenario unfolding before them, and began to realize it would take a Williams-BMW failure for a Ferrari to win today.
Or maybe not. If Montoya led by around five seconds, Ralf, in second place, looked vulnerable to attack from Barrichello, and at the start of lap 47 Barrichello got alongside the Williams on the run down the pit straight, overtaking it into the first chicane. The question now was whether or not, in the six laps remaining, he could do anything about Montoya's seven-second lead.
The answer was not long coming. If the Ferrari trimmed the Williams' advantage, it was only by a couple of tenths here and there, and no one doubted Montoya when he said he was never worried by Barrichello's charge.
At the flag, Montoya was 5.1 seconds ahead, with Barrichello second, Ralf third, Michael a distant fourth.
Back in the paddock, Frank Williams and Patrick Head were plainly delighted. "What really pleases me," said Head, "is that Juan Pablo has got his first victory this season, rather than having to go into the winter thinking about it."
Montoya was a picture of quiet dignity on the podium, standing there, smiling proudly as, for the first time ever, the Colombian national anthem was played after a grand prix. If his sour-faced teammate couldn't bring himself to shake hands, well, so be it."I'm so pleased by this result," Montoya said. "In my first year in F1 I wasn't really expecting to win. I've been close before, but I just thought when the day comes, it will come. My father is here today, and it's his birthday. It's also exactly a year since my last win, in CART. Pretty good, isn't it?"
Pretty good, yes.
QUOTEBOOK:JUAN PABLO MONTOYA (Williams-BMW, winner): "It was a tough season sofar, we had good and bad results, and a lot of bad luck, and now we turnanother page. Three poles and a win are not so bad. Considering it's myfirst year, I wasn't really expecting to win when I came in. I had acouple of opportunities where I could have won it, and I just said 'Whenthe time is meant to come, it will come.' I think it's a great day forme. My father is here; it's his birthday today, so it's pretty good.Exactly a year ago was my last win in CART, so that's pretty good, too."(On when Barrichello passed him on Lap 9): "I got a blister on a reartire, and I started sliding under braking. I made a mistake, and he justpassed me. Afterward, it took me a couple of laps to get back in thegroove, and I learned to really drive the car with that amount ofoversteer, and actually at the end of the run I was fairly quick. Then Ithink they went a bit too extreme with the front wing when I came in. Wedecided to take two holes out and it was a bit too much, so for half ofthe next run I had tons of understeer everywhere. Then it got better andbetter. The speed was there when I needed to turn it on."
RUBENS BARRICHELLO (Ferrari, second, on his overtaking maneuvers onMontoya and R. Schumacher): "Juan Pablo had a problem with the reartires, he locked up when he saw that I was coming on the inside. We justhad a fair fight, and I went through. Ralf was struggling with the reartires, too. I saw he was struggling on brakes into Turn 1, as well, andso I thought I would brake a little earlier so we could both getthrough. He wanted to go on the outside and couldn't go through thechicane so we both lost time, but it was OK." (About pit stop problem):"I am not quite sure what happened in the pit stop, but it cost me a lotof time - enough to lose the race."
RALF SCHUMACHER (Williams-BMW, third): "This was a difficult race forme, and with each set of tires I suffered understeer. The car was tooslow, and furthermore we made mistakes. I did not find the best setupfor my car the whole weekend. But I would like to thank the team, beingfirst and third here is a very strong effort. Because of the bad thingsthat have happened, I find it difficult to celebrate, so I hope everyoneunderstands the reasons for my reaction to what is going on."
MICHAEL SCHUMACHER (Ferrari, fourth): "Luckily, everything went well,and nothing happened. I am glad this weekend is over. It was a pity thatRubens was not able to win this race. But overall, the most importantthing is that nothing bad happened this afternoon."
PEDRO DE LA ROSA (Jaguar-Cosworth, fifth): "That's the boost we've beenwaiting for. The past few races haven't been very good, and I am justdelighted for everybody in the team. Everything went like clockworktoday. The Jaguar R2 felt very well balanced throughout, and I didn'tsuffer from any problems. My worry beforehand was the first chicane, andI'm just glad I made it through there without incident. Jenson Buttonmade a great start but came flying into the chicane and took a fewpeople out. I took advantage of the confusion and was surprised athaving gained four places by the end of the first lap. The Michelintires worked very well and given that I was on a one-stop strategy, Ididn't push to the limit for fear of causing excessive tire wear. As thefuel level lowered and the tires were run in, the car felt great, likeit has all weekend. We'll aim to carry this momentum into the next tworaces, and let's see where it gets us."
JACQUES VILLENEUVE (Lucky Strike BAR-Honda, sixth): "A happier end to adifficult weekend. As predicted, we were a lot better in the race thanwe were in qualifying. The team worked very hard yesterday and thismorning and, somehow, the car was a lot quicker in race trim. We had asmall problem with the fuel rig, and we weren't able to put enough fuelin at the pit stop. This meant we were a little low on fuel toward theend of the race so I couldn't really race de la Rosa. However, sixthplace gives us a valuable point at this stage in the season."
DAVID COULTHARD (West McLaren-Mercedes, retired Lap 7): "There is nodoubt that this has been a race of attrition. Unfortunately, this didn'twork to our advantage as both Mika and I retired. It's been a difficultweekend for us with a few problems along the way, but we still hoped toget points. At least I retained my second place in the Championshippoints standings."
MIKA HAKKINEN (West McLaren-Mercedes, retired Lap 20): "The pileup atthe first corner after the start caused me to go straight on at thechicane, which cost me several positions, and I came out 13th. This wasextremely disappointing as us drivers had discussed that we should beparticularly careful at the start, as the first chicane is so tight. OnLap 19, I got stuck in fifth gear and as I went around the chicane, Ilost all the gears, and that was the end of my race."
GERHARD BERGER (BMW motorsport director): "It is not the correct momentto be happy, but seeing both the drivers on the podium is obviously agreat success for us. Juan Pablo first, Ralf third, that is our bestresult so far. We expected Ferrari to be a very strong competitor, andwe were right to do so. The race showed there was no room to make eventhe smallest mistake. This victory will make Juan Pablo's confidenceeven stronger, and I am sure we will see more strong drives from him."
JEAN TODT (Ferrari sporting director): "I am happy for two reasons. Thefirst is that this difficult weekend is now over. The second is that wegot a car to the podium and another across the line in fourth place.Rubens drove a really great race, and he could have won. Unfortunately,a problem with the resetting of the refueling rig, at the moment of hisfirst pit stop, cost him around seven seconds, which was probably enoughto deprive him of the victory. As for Michael, he drove a good race in aprofessional manner. For various reasons, his heart wasn't in it at thistrack. We would have liked to celebrate our two world titles in front ofall our fans, but world events meant this would have been inappropriate.For us, this race was just another round out of the seventeen. On behalfof all the team, I send our best wishes to Alessandro Zanardi. Thethoughts of all of us are with him today."
NEWS and NOTES:
F1 must race in the U.S.: Jarno Trulli supports the decision to stillhold the SAP United States Grand Prix at Indianapolis on Sept. 30despite the recent terrorist attacks.
"It's for sure a difficult weekend because we all can see what ishappening in the USA, but it's not just a U.S. tragedy, I think it isthe whole world's tragedy," said Trulli. "We have to look at what'shappening, and the feeling in the paddock is not the best: No one ishappy. Normally Formula One is a celebration, but there's nothing tocelebrate here when we see what is happening around the world. There isstress. Everybody is concerned, and the first thing when you wake up inthe morning is to turn the television on to see if there is any news,and you just hope that it can all get better.
"We have to show to everybody that we are together with the USA, that weare all together in the whole world. Formula One is a sport, and allsport is also a way to show somehow that the whole world doesn't have tostop. We still have to carry on, we have to take care of what ishappening, but we can't stop otherwise the people that attacked the USAwill have won their battle and we cannot let this happen. We have toshow that we are strong enough, and we have to look forward."
Ferrari pays tribute: The Ferraris ran with no sponsor logos andwith their noses painted black.
"We feel that we cannot ignore what has happened this week in the UnitedStates," said Ferrari Sporting Director Jean Todt. "We can do littleabout it; we all feel very concerned, very sad for them, for us. Butlife goes on. We are all focused on our business, but it's a differentweekend from all the others, and we had to do something different, andin agreement with our partners it was decided that we should have aplain red car with a black nose.
"It's our little contribution to show to the world that Ferrari and itspartners are concerned with this tragedy."
McLaren announces driver lineup for 2002: The West McLaren-Mercedes teamhas announced its driver lineup for the next year, as Kimi Raikkonenwill replace Mika Hakkinen, who will take a sabbatical. David Coulthardreturns to McLaren for a seventh season, and Alexander Wurz willcontinue as the team's test/reserve driver.
Hakkinen's F1 career spans 11 years during which he won two WorldChampionships, 26 poles and 19 races.
"Formula One has been virtually my whole life since I started karting in1974," Hakkinen said before the race. "The intensity of my career hasbecome increasingly difficult for those around me. Whilst this year hasbeen difficult for me and the team, these experiences have not guidedthe decision to take this break. I asked the team for a break, whichwould be a good way to recharge my batteries and enjoy more time with mywife, Erja, and my son, Hugo.
"I'm pleased to welcome a fellow Finn to the team, and I wish Kimi allthe best. However, let's not forget that there are three races left forme this year, and I have every intention of going flat-out. Of course,it might have been easier to retire, but that just isn't a decision Ifeel ready to take. I know that I will have to work hard to return aftermy break but know that I want to return with West McLaren Mercedes."Finland's Raikkonen, 21, in his first season with F1, had a three-yeardeal with Red Bull Sauber-Petronas but has been released from thatcontract.
"I'm pleased to have achieved several point-scoring finishes with theSauber team after they gave me the chance to show what I could do inFormula One," Raikkonen said. "I really want to thank Peter (Sauber) forhelping me to take the opportunity to drive for West McLaren-Mercedesnext year. However until then, I will do everything I can to help theSauber team retain their fourth place in the Formula One ConstructorsWorld Championship."
Drivers make history: Tomas Enge and Alex Yoong made their F1 debuts inItaly and became the first drivers from the Czech Republic and Malaysia,respectively, to participate in a Grand Prix.
Enge finished 12th, one lap down, in his Prost-Acer. Yoong completed 44of the 53 laps before spinning off in his Minardi-European.
FINAL RESULTS:
1. Juan Montoya, Williams-BMW, 53 laps at 148.723 mph avg. speed
2. Rubens Barrichello, Ferrari, 53
3. Ralf Schumacher, Williams-BMW, 53
4. Michael Schumacher, Ferrari, 53
5. Pedro de la Rosa, Jaguar, 53
6. Jacques Villeneuve, Reynard-Honda, 53
7. Kimi Raikkonen, Sauber-Petronas, 53
8. Jean Alesi, Jordan-Honda, 52
9. Oliver Panis, Reynard-Honda, 52
10. Giancarlo Fisichella, Benetton-Renault, 52
11. Nick Heidfeld, Sauber-Petronas, 52
12. Tomas Enge, Prost-Acer, 52
13. Fernando Alonso, Minardi-Ford, 51
14. Enrique Bernoldi, Arrows-Asiatech, 46 (engine)
15. Alex Yoong, Minardi-Ford, 44 (accident)
16. Heinz-Harald Frentzen, Prost-Acer, 28 (engine)
17. Jos Verstappen, Arrows-Asiatech, 25 (electrical)
18. Mika Hakkinen, McLaren-Mercedes, 19 (gearbox)
19. Eddie Irvine, Jaguar, 14 (engine)
20. David Coulthard, McLaren-Mercedes, 6 (engine)
21. Jenson Button, Benetton-Renault, 4 (engine)
22. Jarno Trulli, Jordan-Honda, 0 (accident)
TIME OF RACE: 1h 16m 58.493s
MARGIN OF VICTORY: 5.175 seconds
FAST QUALIFIER: Montoya; 1:22.216 (157.634 mph)
FASTEST RACE LAP: R. Schumacher; 1:25.073 (152.340 mph)
LAP LEADERS: 1-8, Montoya; 9-19, Barrichello; 20-28, Montoya; 29-35, R. Schumacher; 36-21, Barrichello; 42-53, Montoya
CAUTION PERIODS: None
INJURY REPORT: None
POINT LEADERS: 1. M. Schumacher, 107; 2. Coulthard, 57; 3. Barrichello, 54; R. Schumacher, 48; 5. Montoya, 25; 6. Hakkinen, 24; 7. Villeneuve, 12; 8. Heidfeld, 11; 9. Raikkonen, Trulli, 9
NEXT: Indianapolis, Sept. 30 (1:30 p.m. Eastern, ABC)


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