DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group.
Polymorphisms of DNA repair genes RAD51 and XRCC3 increase susceptibility to acute myeloid leukemia (AML) in adults, an effect enhanced by deletion of the glutathione-S-transferase M1 (GSTM1) gene. In this study, we genotyped 452 children with de novo AML treated on CCG protocols 2941 and 2961 and compared genotype frequencies with those of normal blood donors, and analyzed the impact of genotype on outcome of therapy. XRCC3 Thr241Met, RAD51 G135C and GSTM1 genotypes did not increase susceptibility to AML when assessed singly. In contrast, when XRCC3 and RAD51 genotypes were examined together a significant increase in susceptibility to AML was seen in children with variant alleles. Analysis of outcome of therapy showed that patients heterozygous for the XRCC3 Thr241Met allele had improved post-induction disease-free survival compared to children homozygous for the major or minor allele, each of whom had similar outcomes. Improved survival was due to reduced relapse in the heterozygous children, and this effect was most marked in children randomized to therapy likely to generate DNA double-strand breaks (etoposide, daunomycin), compared with anti-metabolite (fludarabine, cytarabine) based therapy. In contrast, RAD51 G135C and the GSTM1 deletion polymorphism did not influence outcome of AML therapy in our study population.


text:
72% of Americans Want Coronavirus Stay-at-Home Orders to Remain in Place Until Health Officials Say It's Safe: Poll
By Christina Zhao On 4/21/20 at 11:46 PM EDT
U.S. Coronavirus
An overwhelming majority of Americans have indicated that they want stay-at-home orders to remain in place until health officials and experts say it's safe to reopen the economy amid the coronavirus pandemic, according to a new study.
In the latest Reuters-Ipsos poll, released Tuesday, 72 percent of U.S. adults said quarantine measures should remain in place "until the doctors and public health officials say it is safe." The figure includes 88 percent of Democrats, 55 percent of Republicans and 70 percent of independents.
Forty-five percent of Republicans surveyed said they wanted the stay-at-home measures to end, a significant increase from the 24 percent seen in a similar poll released late March. The national poll, conducted online between April 15 to 21, surveyed 1,004 adults. The margin of sampling error is plus or minus 6 percentage points.
People wearing a face masks due to COVID-19 walk near the red cube sculpture on April 20, 2020 in New York City. Eduardo MunozAlvarez/Getty
The results come after small protests broke out in several states—among them Ohio, Minnesota and Michigan—with demonstrators taking to public spaces to demand an end to the stay-at-home orders that have drastically slowed the spread of Covid-19, as well as the country's economy.
Democratic state governors—including Virginia's Ralph Northam, Kentucky's Andy Beshear and Michigan's Gretchen Whitmer—have condemned the protesters for opposing the orders that were put in place to keep them safe. Many of the protesters across the country ignored the White House's social distancing guidelines that advised against gatherings of 10 or more people to battle the novel virus' spread.
Health officials have warned that the U.S. may experience a second wave of the disease if social distancing measures and mitigation efforts are lifted prematurely. Some have also stressed the need for widespread testing and an effective contact-tracing program before the country can begin to reopen safely.
Barr Says Stay-at-Home Orders Are 'Disturbingly Close' to House Arrest
Texas Governor Abbott Says Nearly Half a Million Jobs Are Now Open
Global Coronavirus Cases Pass 2.5 Million
President Donald Trump sympathized with the protesters and declined to condemn their actions during Sunday's White House Coronavirus Task Force press briefing. Instead, Trump criticized the governors—who've had to balance public safety and calls from the president to shorten their lockdown orders—for allegedly taking restrictions too far.
"Some have gone too far, some governors have gone too far. Some of the things that happened are maybe not so appropriate," Trump said. "And I think in the end it's not going to matter because we're starting to open up our states, and I think they're going to open up very well."
Some protesters were seen wearing Make America Great Again apparel, holding pro-Trump signs and confederate flags as they called for coronavirus mitigation measures to be relaxed and wider freedoms amid the pandemic. Whitmer called the protest in her state of Michigan "essentially a political rally."
Newsweek reached out to the White House for comment.
As of April 21, more than 819,100 individuals had tested positive for the coronavirus in the U.S., with over 45,300 deaths caused by the new disease and 82,900 recoveries.

redpajama_set_name: RedPajamaCommonCrawl


With our blend of Staffing, Onshore, Offshore Project Teams, and any combination in between Microexcel's adaptive delivery model allows us to be successful delivering your needs, managed the way want.
Meet your short-term needs for supplemental staffing without HR and Project Management overhead. Our certified professionals will work directly on your projects while onsite at your specified location. We offer both short and long term arrangements to meet your specific needs.
Microexcel's Agile environment is one in which collaborative teams are empowered and motivated to produce timely, cost-effective, and high quality software that meets the needs of its stakeholders and customers while working remotely at one of our regional facilities.
Microexcel has three offshore locations in India, strategically placed at Hyderabad, Pune and Bangalore with over 300 employees to provide support in the areas of designing, programming, QA and Interactive services.


Joane M. Wyrick, Linda Ogden Niemeyer, Melanie Ellexson, Karen Jacobs, Sallie Taylor; Occupational Therapy Work-Hardening Programs: A Demographic Study. Am J Occup Ther 1991;45(2):109-112. doi: 10.5014/ajot.45.2.109.
A survey was conducted of 192 work-hardening and work-adjustment programs to gain an overview of practice patterns. The questionnaire covered program affiliation, services offered, staffing, program scheduling, average length of treatment per client, equipment used, physical settings, program status, number of clients seen each week, and types of functional outcome studies and research. The results demonstrate the tremendous growth of the involvement of occupational therapy in work hardening. This demographic study provides baseline information that can assist in the examination of trends and the development of new programs.


text:
Q: angular-snap slide out menu i am newbie to angular snap. I have the following requirement:

*

*Slide out menu left side

*should contain sub menus

*Sub menus also should be collapsible.

Does angular snap will provide all these features?
I started working on example with angular snap slide out menu.
How do we give two different menus in the drawer and when the user clicks on menu1, main div should display page1 and when user clicks on menu2, main div should display page2.

A: Two small points:

*

*Angular.js is a framework for building single page applications.

*Snap.js is a library that provides a "shelf" like menu interface.

Angular Snap is simply an integration of these two components. You aren't limited from using normal JavaScript to show and hide elements on a page based on a users's click.
Rather than tell you how you should get Angular Snap specifically to do this, here's a way to implement a dropdown hide/show action in Angular, which is absolutely compatible with your Snap.js app instance.
Angular.js Dropdown
function dropdown($scope) {

    $scope.subitems = [
        {
            title: 'Menu item one',
            url: '#'
        },
        {
            title: 'Menu item two',
            url: '#'
        },
        {
            title: 'Menu item three',
            url: '#'
        },
        {
            title: 'Menu item four',
            url: '#'
        }
    ];
}

    Dropdown Menu

            {{subitem.title}}

To my earlier point, you shouldn't necessarily consider integrating this an end-all be all solution to your issue. There are probably simpler solutions in a few lines of JavaScript, and unless your menu items need to be dynamic, I wonder if it's isn't just producing extra overhead and debugging to have Angular produce markup that could be hard-coded.
Either way, I would take into account all of your requirements and go from there. Don't consider these libraries a limitation--there's no part of either of them that isn't JavaScript, so possibly consider other out of the box or easy to implement solutions that use simple tools that already exist in the browser.
EDIT: Borrowed some code from here

redpajama_set_name: RedPajamaStackExchange


text:
Bloomingport/Bloomingsport
Photo taken February 21, 2022. From the author's collection.
Washington Township's District 12 schoolhouse was located in Bloomingport, a small community between Lynn and Carlos alternatively known as Bloomingsport or Blooming Port (Pitts, 1997). Built in 1879 south of the intersection of West County Road 950-South and Bloomingport Road, the schoolhouse was scheduled to be remodeled in 1915 in order to allow it to take in the students of the closing schools at districts 11 and 14 (Hinshaw, 2008).
Instead, township officials condemned it in order to build a larger schoolhouse that could accommodate the students from districts 8, 9, 11, 12, and 14 (School, 1917).
The consolidated school at Bloomingport closed thirteen years later when its students were sent to attend classes at Lynn, a larger community 4.5 miles northwest (Winchester, 1930).
Though the 1917 schoolhouse stood for some time and was used by a religious organization that called it the Bible Deliverance Temple in the 1960s (Brantley, 1962), it is no longer standing.
The 1879 schoolhouse remains. Today, it's a home.
Pitts, E. (1997, March 31). Local residents good sports about extra 's'. The Muncie Star Pres. p. B1.
School Contract Awarded (1917, June 18). The Muncie Press. p. 2.
Winchester Is Dried Up (1930, September 6). The Muncie Evening Press. p. 7.
Brantley, B. (1962, February 4). Store at Bloomingsport- Survivor of By-Gone Age.


text:
Q: Trying to find amount of Saturdays that fall on the last day of each month in Ruby I am working on a very specific problem. I need to find the number of times that Saturday falls on the last day of each month within a five year time period.
For this example, I need to find those Saturdays from 1/1/1990 to 1/1/1995.
I've already tried the following code.
require 'active_support/core_ext'
require 'date'

beginDate = Date.parse("1/1/1990")

endDate = Date.parse("1/1/1995")

saturdays = beginDate.upto(endDate).count(&:saturday?) && beginDate.upto(endDate).count.end_of_month

puts saturdays

Does anyone have any suggestions or pointers?

A: You don't need any ruby-on-rails crap here in the first place. Plain ruby would perfectly do.
require 'date'
beginDate, endDate =
  Date.parse("1/1/1990"), Date.parse("1/1/1995")
(beginDate..endDate).count do |d|
  d.saturday? && d.month != (d + 1).month
end
#⇒ 9

A: Mobile, so can't test, but something like  (0..11).map.with_index { |i| date = Date.today + i.months; date.beginning_of_month if date.end_of_month.saturday? }.reject(&:nil?)


Khao man gai is the Thai version of Hainanese chicken rice. This steamed chicken and rice dish is extremely popular in Singapore, Malaysia, Thailand and Vietnam. The Thai version, Khao man gai, translates as oiled rice with chicken. To make this dish, a whole chicken is simmered in water with salt, sugar, garlic, ginger, and pandan leaves. The jasmine oiled rice accompanying the chicken is made by sauteing the rice with shallots, garlic, ginger, galangal, and pandan leaves in chicken fat then adding broth. This makes the rice flavorful and gives it its oily texture. The dish is served with sliced cucumbers, fresh cilantro, and sauce made of soybean paste, soy sauce, garlic, ginger, red eye chillies, and white vinegar. An excellent primer for making khao man gai is offered by Nong Poonsukwattana of Nong's Kaho Man Gai in a video I found on her website. A cup of chicken broth with thickly sliced daikon is served on the side.
My first encounter with khao man gai was a lunch I had at Nong's Khao Man Gai in Portland. When I moved to the area, I began researching food trucks. Nong's was always listed as the best. I was a bit skeptical. What could be special about steamed chicken with rice? Finally, my curiosity took over and I headed to Nong's storefront in Portland. It was amazing — it was one of those meals where I just sit and eat slowly and hope that it never ends.
So, when I noticed that the owners of Ginger Pop were opening a restaurant for khao man gai I was excited. Khun Jo's has a fresh, modern, clean look to it. The whimsical Khun Jo's chicken symbol is placed on different parts of the walls. Before reaching the counter there was a nice variety of Khun Jo's teas and baked goods neatly organized and tastefully packaged.
I ordered at the counter. Khun Jo's has a short menu — the main dishes are khao man gai (steamed chicken and rice), khao gai todd (fried chicken and rice), peek gai tod nahm pla (fish sauce marinated fried chicken wings), and khao kamoo (stewed pork leg, egg and rice). Khao is the Thai word for rice; so, there is a clear focus here — chicken or pork and rice. I was a bit tempted by the fried chicken; however, I am always on the lookout for quick, inexpensive, healthy dining. And, I was dying to try their khao man gai. The food was brought to me shortly after I ordered. It was a chilly day; so, I went for the chicken broth first.
The broth was warm. It had a rich chicken flavor enhanced by a bit of ginger and garlic. The two thick slices of daikon at the bottom of the broth were tender and toothsome. The soup was soothing and revitalizing — the perfect thing to sip on a cold day.
My attention then turned to the khao man gai. It looked a bit mixed up. I am used to neat slices of chicken placed carefully together; but, I don't mind a messier looking dish if it tastes good. The choices of chicken for khao man gai are white meat, dark meat, or mixed type of chicken. I opted for a mix of white meat and dark meat. Unfortunately, the chicken was overcooked — it was chewy and dry.
The other components of the dish — rice, sauce, garnishes were good. The rice was a good quality jasmine rice perfectly cooked (just the right amount of firmness and tenderness) and seasoned (nice garlic and ginger flavors). The sauce was very good — it had a nice salty and sweet flavor with a good amount of ginger and just a hint of chile. The cilantro was fresh. The cucumber slices had a bit of a funky flavor, lacked a good crunch — they were not very fresh. Despite the fact that the rice, the sauce, the soup, and the fresh cilantro were all good — they could not disguise the fact that the the chicken was overcooked. The dish is topped with crispy, fried chicken skin — this is not a traditional topping. But, who doesn't like a bit of hot crisp chicken fat? It made me think that maybe I should have ordered the fried chicken.
I really enjoyed being at Khun Jo's and I would love to be able to get a good khao man gai on this side of the river. If the chicken was moister, I would be at this restaurant all the time.
Khun Jo's is located at 2100 SE 164th Avenue, Suite A-109 in Vancouver. Their hours are Monday through Saturday 10:30 am – 8:00 pm.


The Knott Bump & Us: Last Week's Vlog - featuring a dancing daddy!
Catch up with last week's vlog before this week's one goes up tomorrow!
We had lots of fun last week and were super busy doing all sorts. There was lunch with friends, baby dates and a road trip to Bath which is such a beautiful city.


When it comes to medical faculties within the USA they'll now be classified beneath two categories. In India , admission to medical faculties is organized each by the central authorities CBSE in addition to the state governments via checks generally known as entrance examination Students who've successfully completed their 10+2 (Physics, Chemistry and Biology Marks are thought of and PCB is necessary) training (larger secondary faculty) can appear for the exams the identical yr.
The United Kingdom boasts the most entrants of any European countries in this yr's rating, with 41 out of the five hundred high universities for drugs based within the UK. After Oxford, Cambridge and UCL in the prime 10, six more UK medical colleges function in the high 50, including Imperial College London (=12th), King's College London (16th, up from twenty first) and the University of Edinburgh (23rd).
They nevertheless need to be acknowledged after assembly a set criteria by a central regulatory authority referred to as Pakistan Medical and Dental Council (PMDC) in Islamabad There are almost equal number of government and personal medical schools and universities, with their quantity exceeding 50. Admission to a government medical faculty is highly competitive.
In order to attend further research (Surgery, Internal drugs, G/OB, Pediatrics, Psychiatry), the scholars within the year of Social service or graduates of any Salvadorian college should apply independently for the residency to the hospital of alternative; the preliminary selection course of relies on the outcomes of medical information tests, adopted by psychiatric evaluations and interviews with the hospital medical and administrative employees.
Once you're glad together with your MCAT scores, the subsequent step of the applying process for medical college is to put collectively a list of which schools you want to apply to. Some faculties do not settle for worldwide college students at all, so you will have to ensure you investigate each school's rules of admission earlier than you apply.


text:
Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans
Colin R. Parrish, Pablo R. Murcia, Edward C. Holmes
S. Schultz-Cherry, Editor
Colin R. Parrish
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Pablo R. Murcia
Medical Research Council—University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Edward C. Holmes
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia
S. Schultz-Cherry
Influenza A virus (IAV) infections in hosts outside the main aquatic bird reservoirs occur periodically. Although most such cross-species transmission events result in limited onward transmission in the new host, sustained influenza outbreaks have occurred in poultry and in a number of mammalian species, including humans, pigs, horses, seals, and mink. Recently, two distinct strains of IAV have emerged in domestic dogs, with each circulating widely for several years. Here, we briefly outline what is known about the role of intermediate hosts in influenza emergence, summarize our knowledge of the new canine influenza viruses (CIVs) and how they provide key new information on the process of host adaptation, and assess the risk these viruses pose to human populations.
Avian influenza viruses (IAVs) frequently spill over from their reservoirs in aquatic birds and infect humans but are generally poorly transmissible (1–3). It is often thought that the infection and transmission of avian influenza viruses among nonhuman mammals, particularly swine, facilitate their subsequent transfer to humans in a form that can be readily transmitted (2, 4–7), although evidence for such "intermediate" mammalian hosts in the emergence of human influenza viruses is limited. Among the few clearly documented examples is the 2009 H1N1 pandemic virus, for which there is strong evidence that it emerged in humans following the transfer of a swine influenza virus, itself comprised of gene segments of swine, human, and avian origin (8, 9). In addition, human viruses can frequently "spill back" to pigs (10, 11), suggesting that they comprise a single virus gene pool. Indeed, anthropozoonotic infections are far more common in pigs than are human infections with swine influenza viruses (12). The emergence of the H1N1 influenza virus in 1918 involved parallel epidemics of the virus in humans and swine, although it is unclear whether the virus emerged in humans and then spread to swine or the reverse (13). Similarly, although reassortment between avian and human viruses resulted in the emergence of the pandemic H2N2 virus (with new hemagglutinin [HA], neuraminidase [NA], and PB1 gene segments) and H3N2 virus (with new HA and PB1 gene segments) in 1957 and 1968, respectively, conclusive evidence of involvement of swine or another mammalian intermediate is lacking.
Only a small number of mammalian hosts are currently recognized as sustaining IAV transmission (Fig. 1), and it is not clear what distinguishes these species from those for which influenza has not been reported. Influenza viruses appear to be relatively host specific in mammals. A variety of barriers to virus infection are known, including innate immune responses and sialic acid receptors as well as a number of intracellular factors, and some viral mutations that overcome these barriers to facilitate replication and spread in new hosts have also been identified (14). Establishment of IAVs in new hosts is also dependent on the structure of the host population, which must be sufficiently large and interconnected to allow the sustained spread of the virus. In the last few centuries, the human population has increased significantly in size and connectivity, as have those of domestic food animals such as poultry, swine, and cattle in intensive agriculture, companion animals (cats and dogs) in households or in kennels or shelters, and some small animals raised in large numbers for fur or meat (15–17). Bats may also be present in large, interconnected populations and appear to maintain their own IAVs, although these are phylogenetically distinct and have not been detected so far in other mammals, such that they are not an important reservoir (18, 19).
Schematic showing the known emergence events of influenza A viruses in mammals that led to extended outbreaks, including epidemics and pandemics. The diagram indicates the known mammalian hosts (humans, swine, seals, mink, horses, and dogs), as well the approximate periods during which those were known to sustain natural transmission in that host. The viruses are all assumed to have emerged from avian reservoirs to infect the initial mammalian hosts. The three known transfers between different mammalian hosts that went on to establish epidemics in the new hosts are indicated by red lines, and the first mammalian host therefore acted as the intermediate reservoir host for the transferred virus. The direction of transfer of the 1918 H1N1 virus is not known for certain, but the virus is now thought to have transferred from humans to swine, rather than the other way around. The transfers of new AIV gene segments into the human virus lineage are shown by the vertical arrows, and the segments are listed; these are assumed to involve a direct transfer of the gene segments from the avian ancestor in humans. There have been complex mixtures and transfers of genome segments among some of the viruses in swine, but most of those are not shown because they have not involved transfer between different hosts.
The emergence of CIVs.The inventory of mammalian hosts that are known to sustain transmission of IAVs has increased in the past 15 years due to the emergence of two strains of the virus in dogs: the H3N8 equine influenza virus (EIV) that transferred to dogs in the United States in about 1999 and the avian virus-like H3N2 strain that transferred to dogs in Asia around 2005 or 2006. Both of these canine influenza viruses (CIVs) have continuously circulated in the dog population since they emerged, creating many opportunities for exposure in humans and other species.
Equine and canine H3N8 influenza viruses.Horses have been natural hosts for sustained influenza transmission on at least three occasions, with an outbreak of an unknown equine influenza virus (EIV) subtype occurring in 1872 (20), an H7N7 EIV that emerged around 1956 (21), and an H3N8 EIV that was recognized around 1963 when there was an outbreak of respiratory disease in Florida that occurred soon after the importation of horses from Argentina (22). The H3N8 EIV appears to have emerged from an avian influenza virus that spread to horses, and there was some reassortment of that virus with the H7N7 viruses in the 1960s and 1970s that eventually died out during the 1970s (23). Limited transmission of H3N8 EIV to dogs, including in the United Kingdom (2002) (24) and Australia (2007) (25), has been observed on a number of independent occasions. However, despite these spillover events, only one EIV transfer that occurred around 1999 in the United States resulted in the establishment of H3N8 canine influenza virus in dogs in Florida, which involved the transmission of a single EIV strain from horses. This outbreak was first described in 2004 as the cause of disease among racing greyhounds, and the virus was transferred within a year to racing tracks in many parts of the United States (26) and, subsequently, to other dog populations and breeds where it has been maintained ever since (27, 28). Notably, H3N8 CIV appears to have been primarily maintained since about 2008 in animal shelters in a few large cities where dogs live in dense populations and where susceptible animals are introduced at high rates (27, 29, 30). Because infected dogs are frequently transferred from these shelters, the virus is often passed to other dog populations where it causes outbreaks but where it is seemingly unable to sustain long-term transmission, likely because of overly heterogeneous contact networks (27, 29). In particular, although there are an estimated 80 million susceptible household dogs in the United States, they appear to lack the degree of contact necessary for continuous transmission of influenza virus such that chains of transmissions quickly die out (29). As a result, CIV infections in small shelters or in the household dog populations die out within days or weeks (27, 29). To date, no reassortment by the H3N8 CIV with any other human or animal influenza viruses has been detected.
It is therefore clear that horses acted as an intermediate host for the emergence of the canine H3N8 strain, although only after about 37 years of continuous circulation of the virus, suggesting that there are major adaptive or epidemiological barriers to CIV emergence. Since its emergence, the H3N8 CIV lineage has diverged from the EIVs that have continued to circulate in horses, with distinct amino acid substitutions in each gene segment, some of which may have been selected for canine adaptation (30, 31). For example, certain amino acid substitutions in the sialic acid binding site modify the replication of the virus in the respiratory tract of the dog by altering the binding to the sulfated glycans and likely by other changes to sialic acid binding (32). Those EIV strains that circulated at the time of emergence of CIV appear to readily infect dogs after experimental challenge or under conditions in which dogs are housed with EIV-infected horses (33, 34) and can infect canine tracheal explant cultures (35), so the amount of adaptation required to infect dogs with these viruses is likely small. Notably, there is currently no evidence for transfer of a CIV back to horses in nature, and CIV replicates inefficiently when used to challenge horses or horse tracheal cells (36–38). Besides the infection in dogs, the H3N8 influenza virus has also been reported to infect pigs in China (39) and to infect cats in experimental studies (40).
H3N2 canine influenza virus.The H3N2 CIV most likely arose around 2005 or 2006 in China but was first recognized in South Korea around the same time, and the virus or specific antibodies have since been detected in many parts of China and Korea, as well as Thailand (41–44). The epidemiology of the H3N2 CIV is still poorly understood, but some reports indicate moderate seroprevalence in some household dog populations, and it has been transferred over long distances both within and between the three countries in which has been detected (45). Populations of farmed dogs may play a role in the maintenance of the virus (46). H3N2 CIV is an avian virus-like strain, and all isolates share a single common ancestor, but the circumstances of the transfer are unknown, and its gene segments are related to both Eurasian and American avian influenza virus lineages (42, 47). H3N2 CIV appears to have a relatively broad host range, and the virus naturally infects cats and spreads among them under some circumstances (48). Under experimental conditions, H3N2 CIV has also been shown to infect ferrets, albeit with limited transmission (49, 50).
Despite its recent emergence, reassortants between H3N2 CIV and other influenza viruses, including a CIV carrying the M segment of human influenza virus H1N1, have been described (51). Another CIV has been suggested to harbor the nucleoprotein (NP) segment of an avian influenza virus related to H5N1 viruses (46), although that is not a clear reassortant (P. R. Murcia, unpublished results). Notably, an H3N1 influenza virus carrying the H3 of CIV and the other gene segments from the H1N1 pandemic human influenza virus has also been reported (52). This should be a cause of concern, as previous influenza pandemics have originated when viruses harboring a novel HA were introduced into the human population.
Intermediate hosts and CIV spread to other species (including humans)?There are only a small number of well-documented examples of mammalian intermediate hosts allowing virus transfer onward to new hosts or acting as "mixing vessels" facilitating reassortment leading to new outbreaks. In addition to transmission of the human H1N1 pandemic virus and the likely role of humans in the emergence of the classical H1N1 virus in swine in 1918, horses clearly played a role in the emergence of the H3N8 virus in dogs. The CIV/human virus reassortant reported for the H3N2 CIV means that we should be alert to the possible emergence of intact or reassortant CIVs in humans. Such a threat results from the extensive and sustained contacts between humans and their pet dogs, which would result in significant human exposure to CIV if the viruses were to spread widely among household dogs. It is also possible that additional reassortments between canine and human viruses could occur in dogs or humans or possibly other hosts such as cats, potentially creating a new human influenza virus for which there may be little or no natural immunity. Clearly, these risks may vary depending on the virus, with H3N2 CIV seemingly posing a greater risk that H3N8 CIV (see below). Importantly, to date there have been no documented transmissions of H3N8 EIV or CIV to humans despite the close interactions between humans and horses since the first appearance of EIV in the early 1960s or between humans and dogs since 2000 (53, 54). However, direct experimental inoculation of human volunteers with EIV in the 1960s showed that infection did occur but only at low levels (55). These results suggest that there are high intrinsic barriers to the establishment of H3N8 in humans, such that onward transmission in two mammalian hosts (horses and dogs) does not guarantee successful infection of another (humans).
In contrast, the observation of H3N2 CIV-human virus reassortants in dogs shows that coinfection of one of the hosts (likely dogs) is possible and hence a cause for concern. In addition, H3N8 EIV has been isolated from pigs in Asia (39) and from bactrian camels in Mongolia (56), and swine are susceptible to infection with many avian virus-like and human virus strains (10, 11). However, the ability of canine influenza viruses to infect pigs (and the ability of pig influenza viruses to infect dogs) has not been formally tested.
Control strategies and CIV eradication.Despite the emergence and spread of the CIVs in both the United States and Asia, there may still be opportunities to control or even eradicate the viruses while they are in their reservoir hosts. Although the household dog population in the United States is about a quarter the size of the human population, the transmission of influenza virus among dogs appears to be much less efficient than that of influenza viruses among humans (27, 29). After 14 years of continuous dog-to-dog transmission, H3N8 CIV is still circulating in a sustained fashion only among dogs in a small number of large animal shelters, and the transmission rate is sufficiently low that the virus might be eradicated from those shelters by reducing the rate of transmission or by reducing the efficiency of infection (29). The spread of the H3N2 CIV in Asia may likewise also be controlled by timely interventions, particularly if the household dog population is similarly inefficient in allowing virus transmission, so that the virus is being maintained in other dog-rearing or -housing facilities.
Concluding remarks.The emergence of canine influenza viruses, like the emergence of any influenza virus lineage in a novel mammalian host population, may constitute a direct or indirect pandemic risk. However, adaptation to mammals should not be seen as a direct conduit to emergence in humans. Clearly, there are important host barriers that have yet to be understood or breached. While the lack of transmission of EIV or CIV to humans suggests that long-standing infection of a mammal does not necessarily indicate a threat to humans, a better understanding of the ecological, evolutionary, and molecular mechanisms of influenza emergence is essential to accurately determine which viruses pose a risk to human health.
C.R.P. and E.C.H. were supported by grant R01 GM080533 from the National Institutes of Health. P.R.M. is supported by the Medical Research Council of the United Kingdom. E.C.H. is supported by an NHMRC Australia Fellowship (AF30).
Webster RG,
Bean WJ,
Gorman OT,
Chambers TM,
Kawaoka Y
. 1992. Evolution and ecology of influenza A viruses. Microbiol Rev 56:152–179.
Govorkova EA
. 2014. Continuing challenges in influenza. Ann N Y Acad Sci 1323:115–139. doi:10.1111/nyas.12462.
Reperant LA,
Kuiken T,
Osterhaus AD
. 2012. Influenza viruses: from birds to humans. Hum Vaccin Immunother 8:7–16. doi:10.4161/hv.8.1.18672.
Scholtissek C,
Naylor E
. 1988. Fish farming and influenza pandemics. Nature 331:215. doi:10.1038/331215a0.
Webby RJ,
Webster RG
. 2001. Emergence of influenza A viruses. Philos Trans R Soc Lond B Biol Sci 356:1817–1828. doi:10.1098/rstb.2001.0997.
Ma W,
Kahn RE,
Richt JA
. 2008. The pig as a mixing vessel for influenza viruses: human and veterinary implications. J Mol Genet Med 3:158–166.
Khiabanian H,
Trifonov V,
Rabadan R
. 2009. Reassortment patterns in Swine influenza viruses. PLoS Curr 1:RRN1008. doi:10.1371/currents.RRN1008.
Smith GJ,
Vijaykrishna D,
Bahl J,
Lycett SJ,
Worobey M,
Pybus OG,
Ma SK,
Cheung CL,
Raghwani J,
Bhatt S,
Peiris JS,
Guan Y,
Rambaut A
. 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122–1125. doi:10.1038/nature08182.
Garten RJ,
Davis CT,
Russell CA,
Shu B,
Lindstrom S,
Balish A,
Sessions WM,
Xu X,
Skepner E,
Deyde V,
Okomo-Adhiambo M,
Gubareva L,
Barnes J,
Smith CB,
Emery SL,
Hillman MJ,
Rivailler P,
Smagala J,
de Graaf M,
Burke DF,
Fouchier RA,
Pappas C,
Alpuche-Aranda CM,
Lopez-Gatell H,
Olivera H,
Lopez I,
Myers CA,
Faix D,
Blair PJ,
Yu C,
Keene KM,
Dotson PD Jr,
Boxrud D,
Sambol AR,
Abid SH,
St George K,
Bannerman T,
Moore AL,
Stringer DJ,
Blevins P,
Demmler-Harrison GJ,
Ginsberg M,
Kriner P,
Waterman S,
Smole S,
Guevara HF,
Belongia EA,
Clark PA,
Beatrice ST, et al
. 2009. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 325:197–201. doi:10.1126/science.1176225.
Crisci E,
Mussá T,
Fraile L,
Montoya M
. 2013. Review: influenza virus in pigs. Mol Immunol 55:200–211. doi:10.1016/j.molimm.2013.02.008.
Lager KM,
Vincent AL,
Janke BH,
Gramer MR,
. 2009. The role of swine in the generation of novel influenza viruses. Zoonoses Public Health 56:326–337. doi:10.1111/j.1863-2378.2008.01217.x.
Nelson MI,
Wentworth DE,
Culhane MR,
Viboud C,
LaPointe MP,
Lin X,
Holmes EC,
Detmer SE
. 2014. Introductions and evolution of human-origin seasonal influenza a viruses in multinational swine populations. J Virol 88:10110–10119. doi:10.1128/JVI.01080-14.
Han GZ,
. 2014. Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus. Proc Natl Acad Sci U S A 111:8107–8112. doi:10.1073/pnas.1324197111.
Cauldwell AV,
Long JS,
Moncorge O,
Barclay WS
. 2014. Viral determinants of influenza A virus host range. J Gen Virol 95:1193–1210. doi:10.1099/vir.0.062836-0.
Gortazar C,
de la Fuente J,
Boadella M,
Martinez-Lopez B,
Ruiz-Fons F,
Estrada-Pena A,
Drosten C,
Medley G,
Ostfeld R,
Peterson T,
VerCauteren KC,
Menge C,
Artois M,
Schultsz C,
Delahay R,
Serra-Cobo J,
Poulin R,
Keck F,
Aguirre AA,
Henttonen H,
Dobson AP,
Kutz S,
Lubroth J,
Mysterud A
. 2014. Crossing the interspecies barrier: opening the door to zoonotic pathogens. PLoS Pathog 10:e1004129. doi:10.1371/journal.ppat.1004129.
Rimmelzwaan GF,
Kuiken T
. 2009. Avian influenza viruses in mammals. Rev Sci Tech 28:137–159.
Matrosovich M,
Stech J,
Klenk HD
. 2009. Influenza receptors, polymerase and host range. Rev Sci Tech 28:203–217.
Tong S,
Conrardy C,
Castillo DA,
Chen LM,
Recuenco S,
Ellison JA,
York IA,
Turmelle AS,
Moran D,
Rogers S,
Shi M,
Tao Y,
Weil MR,
Tang K,
Rowe LA,
Sammons S,
Frace M,
Lindblade KA,
Cox NJ,
Anderson LJ,
Rupprecht CE,
Donis RO
. 2012. A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A 109:4269–4274. doi:10.1073/pnas.1116200109.
Wu Y,
Tefsen B,
Gao GF
. 2014. Bat-derived influenza-like viruses H17N10 and H18N11. Trends Microbiol 22:183–191. doi:10.1016/j.tim.2014.01.010.
Coady JH
. 1977. The 1872 epizootic. J Amer Vet Med Assoc 170:668.
Sovinova O,
Tumova B,
Pouska F,
Nemec J
. 1958. Isolation of a virus causing respiratory disease in horses. Acta Virol 2:52–61.
Waddell GH,
Teigland MB,
Sigel MM
. 1963. A new influenza virus associated with equine respiratory disease. J Am Vet Med Assoc 143:587–590.
Murcia PR,
Wood JL,
Holmes EC
. 2011. Genome-scale evolution and phylodynamics of equine H3N8 influenza A virus. J Virol 85:5312–5322. doi:10.1128/JVI.02619-10.
Daly JM,
Blunden AS,
Macrae S,
Miller J,
Bowman SJ,
Kolodziejek J,
Nowotny N,
Smith KC
. 2008. Transmission of equine influenza virus to English foxhounds. Emerg Infect Dis 14:461–464. doi:10.3201/eid1403.070643.
Crispe E,
Finlaison DS,
Hurt AC,
Kirkland PD
. 2011. Infection of dogs with equine influenza virus: evidence for transmission from horses during the Australian outbreak. Aust Vet J 89(Suppl 1):27–28. doi:10.1111/j.1751-0813.2011.00734.x.
Crawford PC,
Dubovi EJ,
Castleman WL,
Stephenson I,
Gibbs EP,
Smith C,
Hill RC,
Ferro P,
Pompey J,
Bright RA,
Medina MJ,
Johnson CM,
Olsen CW,
Klimov AI,
Katz JM,
. 2005. Transmission of equine influenza virus to dogs. Science 310:482–485. doi:10.1126/science.1117950.
Pecoraro HL,
Bennett S,
Huyvaert KP,
Spindel ME,
Landolt GA
. 2014. Epidemiology and ecology of H3N8 canine influenza viruses in US shelter dogs. J Vet Intern Med 28:311–318. doi:10.1111/jvim.12301.
Anderson TC,
Hernandez JA
. 2013. Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with influenza-like illness in the United States. J Am Vet Med Assoc 242:209–216. doi:10.2460/javma.242.2.209.
Dalziel BD,
Huang K,
Geoghegan JL,
Arinaminpathy N,
Grenfell BT,
Ellner SP,
Parrish CR
. 2014. Contact heterogeneity, rather than transmission efficiency, limits the emergence and spread of canine influenza virus. PLoS Pathog 10:e1004455. doi:10.1371/journal.ppat.1004455.
Hayward JJ,
Scarlett JM,
Janeczko S,
. 2010. Microevolution of canine influenza virus in shelters and its molecular epidemiology in the United States. J Virol 84:12636–12645. doi:10.1128/JVI.01350-10.
Perry IA,
Jang Y,
. 2010. Evolution of canine and equine influenza (H3N8) viruses co-circulating between 2005 and 2008. Virology 408:71–79. doi:10.1016/j.virol.2010.08.022.
Collins PJ,
Vachieri SG,
Haire LF,
Ogrodowicz RW,
Martin SR,
Walker PA,
Xiong X,
Gamblin SJ,
Skehel JJ
. 2014. Recent evolution of equine influenza and the origin of canine influenza. Proc Natl Acad Sci U S A 111:11175–11180. doi:10.1073/pnas.1406606111.
Yamanaka T,
Nemoto M,
Tsujimura K,
Kondo T,
Matsumura T
. 2009. Interspecies transmission of equine influenza virus (H3N8) to dogs by close contact with experimentally infected horses. Vet Microbiol 139:351–355. doi:10.1016/j.vetmic.2009.06.015.
Garretson K,
Quintana AM,
Lunn KF,
. 2013. Comparison of the infectivity and transmission of contemporary canine and equine H3N8 influenza viruses in dogs. Vet Med Int 2013:874521.
Gonzalez G,
Marshall JF,
Morrell J,
Robb D,
McCauley JW,
Perez DR,
Parrish CR,
Murcia PR
. 2014. Infection and pathogenesis of canine, equine and human influenza viruses in canine tracheas. J Virol 88:9208–9219. doi:10.1128/JVI.00887-14.
Bannai H,
Matsumura T,
Muranaka M,
Ueno T,
Kinoshita Y,
Niwa H,
Hidari KI,
Suzuki T
. 2012. No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8). Acta Vet Scand 54:25. doi:10.1186/1751-0147-54-25.
Ishida H,
Kiso M,
. 2010. Infectivity and pathogenicity of canine H3N8 influenza A virus in horses. Influenza Other Respir Viruses 4:345–351. doi:10.1111/j.1750-2659.2010.00157.x.
Hussey SB,
Burr EC,
Annis KM,
Rao S,
. 2011. Evaluation of infectivity of a canine lineage H3N8 influenza A virus in ponies and in primary equine respiratory epithelial cells. Am J Vet Res 72:1071–1078. doi:10.2460/ajvr.72.8.1071.
Tu J,
Zhou H,
Jiang T,
Li C,
Zhang A,
Guo X,
Zou W,
Chen H,
Jin M
. 2009. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol 154:887–890. doi:10.1007/s00705-009-0381-1.
Su S,
Wang L,
Fu X,
He S,
Hong M,
Zhou P,
Lai A,
Gray G,
Li S
. 2014. Equine influenza A(H3N8) virus infection in cats. Emerg Infect Dis 20:2096–2099. doi:10.3201/eid2012.140867.
Song D,
Kang B,
Lee C,
Jung K,
Ha G,
Kang D,
Park S,
Park B,
Oh J
. 2008. Transmission of avian influenza virus (H3N2) to dogs. Emerg Infect Dis 14:741–746. doi:10.3201/eid1405.071471.
Bunpapong N,
Nonthabenjawan N,
Chaiwong S,
Tangwangvivat R,
Boonyapisitsopa S,
Jairak W,
Tuanudom R,
Prakairungnamthip D,
Suradhat S,
Thanawongnuwech R,
Amonsin A
. 2014. Genetic characterization of canine influenza A virus (H3N2) in Thailand. Virus Genes 48:56–63. doi:10.1007/s11262-013-0978-z.
Wang H,
Jia K,
Qi W,
Zhang M,
Sun L,
Liang H,
Du G,
Tan L,
Shao Z,
Ye J,
Cao Z,
Chen Y,
. 2013. Genetic characterization of avian-origin H3N2 canine influenza viruses isolated from Guangdong during 2006–2012. Virus Genes 46:558–562. doi:10.1007/s11262-013-0893-3.
Lee YN,
Lee DH,
Lee HJ,
Park JK,
Yuk SS,
Sung HJ,
Park HM,
Lee JB,
Park SY,
Choi IS,
Song CS
. 2012. Serologic evidence of H3N2 canine influenza virus infection before 2007. Vet Rec 171:477. doi:10.1136/vr.100718.
Yang X,
Liu C,
Liu F,
Liu D,
Zhang H,
Qu L,
Xia D,
Liu M
. 2014. Identification and genetic characterization of avian-origin H3N2 canine influenza viruses isolated from the Liaoning province of China in 2012. Virus Genes 49:342–347. doi:10.1007/s11262-014-1092-6.
Cao N,
Zhao F,
Li H,
Zhao M,
Wang Y,
Huang Z,
Yuan L,
Zhang G,
. 2012. Complete genome sequence of an avian-origin H3N2 canine influenza A virus isolated in farmed dogs in southern China. J Virol 86:10238. doi:10.1128/JVI.01601-12.
Park SJ,
Moon HJ,
Kang BK,
Na W,
Kim JK,
Poo H,
Park BK,
Song DS
. 2012. Complete genome sequence of an avian-origin H3N2 canine influenza virus isolated from dogs in South Korea. J Virol 86:9548–9549. doi:10.1128/JVI.01485-12.
Jeoung HY,
Lim SI,
Shin BH,
Lim JA,
Song JY,
Song DS,
An DJ
. 2013. A novel canine influenza H3N2 virus isolated from cats in an animal shelter. Vet Microbiol 165:281–286. doi:10.1016/j.vetmic.2013.03.021.
Kwon JH,
Nahm SS,
. 2013. Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2). J Gen Virol 94(Pt 2):293–297. doi:10.1099/vir.0.042473-0.
Kim H,
Moon H,
Yeom M,
Kang B
. 2013. Inter- and intraspecies transmission of canine influenza virus (H3N2) in dogs, cats, and ferrets. Influenza Other Respir Viruses 7:265–270. doi:10.1111/j.1750-2659.2012.00379.x.
Seon B,
An DJ,
Kim DJ,
Kim JM,
Kim SH,
Song D
. 30 June 2014, posting date. H3N2 canine influenza virus with the matrix gene from the pandemic A/H1N1 virus: infection dynamics in dogs and ferrets. Epidemiol Infect doi:10.1017/S0950268814001617.
Yeom MJ,
Nam JH,
Oh JS,
Song M,
Kang BK
. 2012. A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea. J Gen Virol 93:551–554. doi:10.1099/vir.0.037739-0.
Khurelbaatar N,
Krueger WS,
Heil GL,
Darmaa B,
Ulziimaa D,
Tserennorov D,
Baterdene A,
Anderson BD,
Gray GC
. 2014. Little evidence of avian or equine influenza virus infection among a cohort of Mongolian adults with animal exposures, 2010–2011. PLoS One 9:e85616. doi:10.1371/journal.pone.0085616.
Burnell FJ,
Holmes MA,
Roiko AH,
Lowe JB,
White SK,
. 2014. Little evidence of human infection with equine influenza during the 2007 epizootic, Queensland, Australia. J Clin Virol 59:100–103. doi:10.1016/j.jcv.2013.11.011.
Kasel JA,
Alford RH,
Knight V,
. 1965. Experimental infection of human volunteers with equine influenza virus. Nature 206:41–43. doi:10.1038/206041a0.
Yondon M,
Zayat B,
Halpin RA,
McKenzie PP,
Gray G
. 2014. Equine influenza A (H3N8) virus isolated from a bactrian camel, Mongolia. Emerg Infect Dis 20:2144–2147. doi:10.3201/eid2012.140435.
You are going to email the following Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans


text:
Casualty rates rise at slower pace during renewals
Matthew Lerner
July 06, 2021 Reprints
Arthur J. Gallagher & Co. Axa USI Insurance Services Agents & Brokers P/C Insurers P/C Pricing More + Less -
General liability and excess umbrella commercial insurance rates increased again during mid-year renewals, but policyholders generally saw smaller price hikes than a year ago, insurance industry sources said.
Capacity is available and can be costly but new capital entering the market can help blunt rate increases.
"We had a lot less of an increase than we anticipated. We were still in double digits from a general liability and umbrella and excess standpoint, but we were anticipating 40% to 50% and ended up with about 10% to 15%," said Penni Chambers, vice president of risk management for Hillwood Development Co. LLC in Dallas.
On average, policyholders did not see increases as high as those in 2020 or 2019, said Douglas O'Brien, national practice division manager for casualty and alternative risk in New York for USI Insurance Services LLC. "I do see a thawing," he said.
While some policyholders are still seeing "significant" increases, they constitute the minority, whereas last year the reverse was true, said Jessica Cullen, managing director, casualty practice, in New York for Arthur J. Gallagher & Co.
Most renewals have seen low- to mid-double-digit increases, but a "handful" over the past six weeks have been in the high single digits, said Adam Mazan, Santa Ana, California-based regional vice president for Risk Placement Services Inc.
Admitted market risks started flowing to the surplus market in the fourth quarter of 2019, but the stream has slowed in the past few weeks as standard markets have become more competitive, sometimes undercutting rates, or occasionally extending larger lines, he said.
"We are seeing less rate than what was achieved in 2020, but rate level increases remain significant — double-digit between 20% and 40% — depending on industry class and attachment point," said Donnacha Smyth, Bermuda-based head of excess casualty for Axa XL in North America, a unit of Axa SA.
Most policyholders went through "one tough renewal" in either 2019 or 2020 and then saw less drastic changes in 2021, with a few "stragglers" seeing the onerous changes this year, Ms. Cullen said.
"Tough" renewals generally included changes in structure, deductibles, terms and conditions, and rates, or at least three out of the four. At subsequent renewals, policyholders likely saw changes in one or perhaps two of those categories, Ms. Cullen said.
Gallagher's 2021 Spring/Summer Market Report shows 63% of its U.S. clients saw a rate increase.
Excess and umbrella markets are "still deploying their capacity selectively," said Mr. O'Brien of USI. Insurers are largely offering limits in blocks of $5 million and $10 million, compared with $25 million lines offered prior to the market hardening. Attachment points can be $2 million but run to as high as $5 million, depending on the nature of the risk, including auto count/exposure.
USI's commercial property/casualty midyear update showed increases for umbrella and excess risks varying by size, with middle-market accounts up 5% to 25% and larger "risk management" accounts increasing 25% to 50%. For both, the increases depended on the class of business covered and limits purchased.
While she did not face challenges assembling the capacity for Hillwood's program, Ms. Chambers said she engaged more insurers than historically because line sizes have been curtailed. Using more insurers means completing more submissions, which creates more work for risk managers, she said. "Risk managers, brokers, and underwriters are all extremely busy."
There is ample capacity in the marketplace, Mr. Mazan said. "That capacity just wants significantly higher rates with much more restrictive terms than what had historically been in the marketplace," he said.
Hillwood operates a charter air business with four 737-300 aircraft used by groups, including regional businesses and athletic teams. Ms. Chambers said "hefty" rate increases continue in aviation markets, but Hillwood was able to differentiate itself by investing in ion dispersant technology – which kills viruses including COVID-19 – for its planes and ended up with "a good renewal."
USI saw increases for most but not all clients, as new market capacity helped to moderate the price hikes. "Some of our more recent renewals have actually taken advantage of some of that capacity in the higher layers," Mr. O'Brien said.
New capacity has helped plug holes in programs and moderate some rate increases, Mr. Mazan said. "I've used new capacity a handful of times to keep rate increases suppressed."
"There are a number of new entrants in the market providing an influx of capacity, which gives clients and brokers some additional opportunities to complete gaps in towers or purchase additional limits," said Mr. Smyth of Axa XL.
Meanwhile, most insurers are requiring explicit communicable disease exclusions, especially for high-exposure industries like hospitality, Mr. O'Brien said.
Insurers are developing their own preferred wording for COVID-19 exclusions, Mr. Smyth said. "Cyber is another area where there has been significant change as the market moves from silent to affirmative or explicit," he added.
Most Read in Risk Management
1. Trump Organization accused of misleading Zurich over surety bonds
2. Chubb names technology executive vice president
3. Insurance sector dodges Great Resignation woes
4. Businesses fear never-ending 'take-home' COVID liability lawsuits
5. Zurich North America makes executive changes
6. Natural disasters in 2021 second-costliest on record
Sign up for Daily Briefing, the free email newsletter from Business Insurance.


I have tested both the NTSC-US and PAL version and both work flawlessly aside from the FMVs not showing up in Hardware mode. Simply press F9 on your keyboard to switch ingame to software mode to watch the FMVs or go to GameFixes and tick "Switch GSdx software rendering when a FMV plays". Both versions work fine but the PAL version which is similar to the japanese version has worse voice acting and it seems they reduced the speed of the voice tracks to sound it slower which sounds just bad.


Who uses Bypass mode, and why?
Discussion in 'Rebuildable Mods and Devices' started by lucifah, Sep 20, 2018.
I'm just curious if anybody actually uses Bypass mode on their regulated mods, and why?
Why would anyone turn a regulated into a semi-mech (presumably safeguards are still in place), which likely has less raw performance than an actual mech?
It's a serious question. I just don't understand the purpose of it.
Nope never use it, why would I buy a VV/VW mod then use it like a direct output stick?
Exactly that's what baffles me Yet almost every regulated device I own has that option for some strange reason.
One manufacturer puts in in as an option, then all the others add that option and add another option .... ad nauseam.
50w mod with VV, 80w mod with VV and VW, 100w mod with VV, VW and TC, 130w mod with VV, VW, TC and Boost, 140w mod with VV, VW TC, Boost and Power curves, 160w mod with VV, VW, TC, Boost, Power Curves and Bypass, 200w mod with VV, VW, TC, Boost, Power Curves, Bypass and Custom TCR, when there's nothing left to add they make pods with no features and the cycle start again or start adding LED's.
Haha yes, that's a very good explanation of the phenomenon!
As world and dog throw pods on the market, I'm now waiting for a pod with rev counter!
I'm surprised nobody as put a step counter in one ..... but maybe I shouldn't be giving them ideas.
I want a TV with all the latest features but with a setting on it that only lets you watch BBC1, BBC2, ITV and Channel 4, automatically fixes the ratio 4:3 and can recreate the 'snow' effect with the push of a button ..... a button on the TV of course because the setting also disables the remote, so you have to get up to change channels for the authentic retro experience.
I use bypass mode when testing my builds before putting them on my mechs.
But the reason for this is I don't have a dedicated ohms reader or tab, so I use a regulated mod for safety, in bypass mode to see how the build will perform.


Campaign Update #76 - Shipping Update Cont.
As I reported earlier this week under the campaign page's general comments section, dispatch should begin this week. For Canadian backers, your rewards are also with GTS.
I want to take this time to mention something that I have overlooked until a couple of days ago (thanks, Ryan Zecman and TheHonestYeti). As we have promised Canadian-friendly shipping, GTS will be sending the packages to Snakes & Lattes for them to dispatch within Canada for our CA backers in order to avoid customs or tax charges.
All of this was organised a long time ago before all the shipments left China. Since then, my brain had lumped everything together as "US fulfilment" and forgot Snakes & Lattes was handling our CA orders.
For any CA backers that want their games dispatched by GTS in the US, please email us team@ruleandmake.com and I'll get an amended order list sent to GTS in the next day or two.
Rewards have started being dispatched this past week from ExChain, and we've already had a couple of reports of the packages as received. Keep an eye out for your reward this coming week or two.
For those in need of support to inquire about the status of your package or have damaged or missing parts, please send your request to team@ruleandmake.com.
Saodhar, AcesofDeath7, and 5 more people like this update.
Never mind, the coins were shipped separately.
Will we be getting an email when shipping has started?
Are the metal coins being shipped separately?


text:
8 Reasons You Should Try An Unnecessary Spending Freeze For "No Spend November"
By Brianna Wiest
If you think about it, it's wild that Western culture finds it totally permissible for us to require hundreds of thousands of dollars of debt just to afford the basic essentials of a good life: a car, an education, a home. What's more interesting is how we more frequently condemn debtors and even guilt ourselves for having to do so — it may be our choice, but what others do we have? This kind of debt, the kind that's unfortunate yet seemingly inevitable for now, does more than just enslave us to work that consumes most of our lives for the next 30+ years. What it does is completely whack out our concept of money. It aggrandizes our idea of what a dollar is really worth. After all: what's a few thousand dollars of debt when your education cost you $100,000?
It sounds like something you only hear at some kind of rally — yet it's such a pervasive reality, I can't help but wonder if, like David Foster Wallace's fish that don't realize they're swimming in water, that's what makes it so hard to see and talk about: we are enslaved to our things. We are at the whim of our finances. Our daily lives are constructed around the work we have to do not to survive, but to repay our debts.
All of this to say: more "things" will not make you happy. How do I know? Because if they did, the ones you've already desired, got, and are in debt over would have done the trick. Secondly, aside from the aforementioned essentials, there is basically nothing that's worth exchanging years upon years of your precious time for: no fancy car, no designer clothes, nothing. This kind of realization requires a good deal of wisdom and an even more profound honesty, and I hope we can all get there.
I propose a little experiment, if you need to move yourself along: no spend November. For one month, you don't spend money on anything but what you need (food, toiletries, etc.) That means nothing extra: no new clothes, no eating out, no new electronics, etc. Exceptions can be made: if something breaks, if something's legitimately necessary, etc., but otherwise, use what you have, and find ways to entertain yourself that don't cost a quarter of your paycheck. Here's what you'll realize by the end:
Your Life Will Feel Much More Grounded
You'll have to actively find ways to let yourself "be," and enjoy what you already have.
You'll Begin To Override The Need To Have Tangible, Physical Representations Of Your Wealth And Success
The idea of "keeping money just for the sake of keeping it" is almost impossible for most people, because we subconsciously believe that unless we're able to physically prove our wealth, it's not legitimate. If it's not tangible, we don't feel comfortable. Rather than see every dollar you earn for what it can buy you, just leave it there, and take what you need when you need it. That's all.
You'll Realize How Much Of Your Financial Anxiety Is Buyer's Remorse
People are rarely stressed about "paying the bills." They're almost always stressed about "paying the bills after I unnecessarily over-spent this month."
You'll Realize That The Best Things In Life Are Free (Cheesy But True)
Or even more, that it's unnecessary to spend as much as you do in a month, all for the sake of "having fun." You'll have more fun hiking, or having friends over, or learning to cook, or reading the books on your shelf that still aren't touched...
You'll See How Quickly The Little Things Add Up
Twenty dollars a day on food, drinks, plus whatever else you spend on fast fashion, drug store pick ups, and so on, is $600 by the end of the month. (Yikes.)
You'll Discover That Being Resourceful Is Fun
It gives you a weird sense of accomplishment.
You'll Start Getting Creative
You'll have to put together new combinations of outfits, ones you've never thought of before. You'll have to whip together dinner with what's in your fridge already. You'll find that not only is this possible — it's also a lot of fun.
You'll Learn To Appreciate — And Fully See — That You Have Everything You Need
Desiring more, more, more wasn't because you were ever truly lacking anything physically, but really had to do with the fact that you were lacking a sense of purpose, or worth, or certainty on your own. Ironically, you'll find that what you do after releasing your desire to consume will be just the antidote you need.
Images: Giphy (5); Pexels


text:
Unsafe asbestos removal at a tenants' home
Home News Unsafe asbestos removal at a tenants' home
by Pam
Barnstaple gas engineer prosecuted following unsafe asbestos removal at a tenants' home
A gas engineer removed potentially dangerous asbestos material during a gas boiler replacement putting himself and others at risk from exposure to asbestos fibres.
Brian Hockin, aged 58, was removing an old warm air heating system at a residential property on Williams Close, Wrafton when he disturbed a quantity of asbestos insulation board that surrounded the warm air boiler.
The tenants of the property raised their concerns with Brian Hockin that he had disturbed asbestos but he continued to remove the material bagging it and removing it from the property and storing it at his yard.
The tenants were so concerned that they contacted Health and Safety Executive (HSE) which prosecuted Brian Hockin at Barnstaple Magistrates' court.
During the hearing the court heard that Brian Hockin used no safety measures to prevent the spread of asbestos and that he used no protective clothing or protective breathing apparatus when he was removing the asbestos.
Brian Hockin of Bickington, near Barnstaple, pleaded guilty of breaching Section 3(2) of the Health and Safety at Work etc Act 1974, and was fined £450 and ordered to pay £921.40 in costs.
HSE Inspector Simon Jones, speaking after the trial, said: "Brian Hockin's negligence could result in serious health effects to both him and anyone else who may have come into contact with the asbestos material that he disturbed.
"Given Mr Hockin's vast experience as a gas engineer he should have realised that there is a very good chance that a 30 year old gas boiler could be insulated with asbestos insulation board but he made no checks before working around the material.
He then compounded matters by ignoring concerns raised the tenants that the material that he had disturbed was asbestos and carried on removing the material.
"Tradesmen should always be aware that asbestos can be found in any industrial or residential building built or refurbished before the year 2000.
"Tradesmen should make enquiries as the presence of asbestos before starting work and if they suspect that they have come across asbestos during work they should stop work immediately and confirm what the material is and arrange for it to be dealt with by properly trained asbestos removers in a safe manner'


Overnight last night the forum was moved to a new server. Some may have noticed that between the hours of midnight and approximately 10AM this morning that the forum was actually down - my apologies.\n\nThings are up and running again and for most users the change should be seamless. It is possible a few responses made by members may have been lost in the changeover so please check any responses you may have made to threads during the evening or overnight hours - if it's missing, you may have to post it again, sorry.\n\nIf you notice anything odd or broken, please respond in this thread and let me know so that I can address it. \n\nI would also appreciate a few responses indicating how fast (or slow?) the forum seems to members - I want to ensure that nothing is being bottlenecked or unexpectedly slowed down because of this change.\n\nThanks all!
Re: Problems or issues? Please let us know!
Thanks for all you do. As far as I can tell, it seems a bit faster on my end.
Works fine for me. I also think that it is a bit faster.\nThanks for keeping this site up!
\nI am not sure why this is happening. Do we have a minimum number of posts before a pm can be set?
On the road, go ahead and send me a private message. I have a feeling that your messages have not been read. I have two in my outbox that are almost two years old.
PM's still showing in your outbox means they have not been received by the recipient. Once they are, they will no longer show in your outbox.\n\nSo, either the member in question has not been online to see them, or has been online and didn't notice them. Some members unfortunately do not enable the notification of PM feature (either via popup or email) so they may sit unnoticed.\n\nIf you are urgently trying to get ahold of someone a staff member can retrieve their email address and privately contact them and request they login and check their PM's. We do not give out peoples email addresses publicly, but we can act as a go-between to get their attention.
Ok, sorry for the false alarm. I thought they weren't sending. Thanks guys.


I've created and ordered a proof copy of Everything Voluntary in Large Print format. It will be sized at 8.5 x 11 inches, and sold for $12.00. I will announce it's availability soon. Here's the CreateSpace.com page for it.


It was built by Raja Man Singh Mirza Raja Jai Singh and Sawai Jai Singh in a built two centuries. It stands in north in Jaipur and was the capital or Kachhawah Rajputs for six centuries. This fort is a fusion of Rajput and Mughal styles. Here is a very beautiful shile mata temple worshiped by thousand of devotes. In this fort, there are many special things to see as Singh pole, Jaleb Chowk, Diwan-e-Aam, Genesh pole a garden char lag style, sukh niwas, jas mandir, beautiful interior scenery, Mohan bari or kesar kyari and the Dileram bagh etc.
The outstanding Mehrangarh Fort or the 'Sun fort' was founded by Rao Jodha in 1459 A.D., when he shifted his capital from Mandore on the advice of a hermit. The 5 kms long impressive fort perched on a 125 m high hill, above the city and overlooks the craggy and pebbly terrain. It is a reputed sentinel to the grandeur of the past, unconquerable and undaunted in its league with time. The entrance from Loha Pole s marked with sati handprints. Jodhpur's chequered history provided its queens with several occasion to prove their fidelity. Marks of mortar balls fired by the invaders can still be seen on the fort walls (in the form of black coloured marks). There are several shrines commemorating the sacrifices of the brave Rajputs, who laid their lives while guarding the fort. The palace within is decorated with long intricately carved panels and latticed windows elegantly created from red stonework. There are also various residences and public offices in the fort. Within the fort are some magnificent palaces with spectacularly carved panels and latticed windows. Among those important are- Moti Mahal (Pearl Palace), Phool Mahal (Flower Palace) or Darbar-e-Khas (Hall of private audience), Sheesh Mahal (Mirror Palace), Sileh Khana and Daulat Khana with a rice varied collection of palanquins, folk music instruments, costumes, furniture and an impressive armoury. The spectacular exhibits of antique cannons on the battlements near Chamunda Devi temple on the far end is the most popular Hindu shrine of the city and among the rarest in India. Large number of devotees visits the shrine especially during the Navratras.
IIt was built in 1156 A.D. by Rawal Jaisal. The imposing golden hued fort or Sonar Killa is balanced elegantly atop the 80 metre high Trikuta Hill. It creates an illusion of growing out of a rock in an undulating sea of sand. The fort built in Jurassic sandstone has its base bordered by a wall of hard stone. The fortresses are in the from of half towers encircled by high tower and joined by broad walls.
The entire living area is will protected inside the ramparts of the fort supports the fortifications forming a double line of defense. It is approached through four gateways- the Ganesh Pol or the 'Elephant Gate', from the main market, followed by the Suraj Pol or the 'Sun Gate', Bhoota Pol or the 'Haunted Gate' and finally the Hava Pol or the 'Wind Gate'. The Hava Pol placed sentry to the royal palaces and leads to the main inclusion, the Hall of Public Audience.. The fort has an enchanting cob-web of narrow lanes dotted with many intricately carved havelis (mansions), which have become the major attraction of the museum city. It also has several ancient beautifully sculptured Hindu and Jain temples dating back to 12th – 15th century A.D.
within the majestic fort. An 8th century A.D. Ganesh temple on an open land attracts thousands of devotees and is the venue for an annual fair held on. Bhadrapad Sudi Chaturthi, fourth day of the bright half, in the month of Bhadra.
This ancient fort perched on a steep cliff, about 304 meters high has been a standing sentinel to the crumbling history of valour and chivalry. It is believed to be constructed by Hasan Khan Mewati in 1492 AD and later occupied by the Jats and Mughals. In 1775 AD, the fort was conquered by Maharao Raja Pratap Singh, the founder of Alwar state. The huge fort extends about 5 km from north to south and 1.6 km from east to west. It has 15 large and 51 small tower with 446 loopholes for musketry. There are six entrances to the fort named Jai Pol, Suraj Pole, Laxman Pole, Chad Pole, Kishan Pole and Andheri Pole.
This unconquerable fort is true to its tough name, as it sustained itself by many British attacks, and frustrated them to the end. It is quite different from the others forts of State. The fort was conceived and designed by Maharaja Surajmal, the founder of Bharatpur. There is no lavishness associated to the fort, but it generates an aura of strength and magnificence. The fort is bordered with a moat which used to be filled with water to defend against the enemy attacks. The sandy parapet was strengthened by sandy battlements, which made the enemy guns ineffective. The fort has some fine monuments like Kishori Mahal, Mahal Khas and Kothi Khas. Moti Mahal and towers like Jawahar Burj and Fateh Burj were erected to memorialize the victory over the Mughals and the British army. The gateway is festooned with paintings of huge elephants.
The white coloured taragarh or the 'Star Fort' is crowning the thickly wooded hill. It was built in 1354 A.D. by Rao Raja Bar Singh and its unique structure makes it almost invincible. In 18th century, when the State was governed through Jaipur state, an outer wall was added to the fort by Fozdar Dalil of Jaipur. There are several exciting monuments within the fort. The centrally located Bheem Burj is the highest Burj (tower) of the fort. Adjoining to the Bheem Burj is a cenotaph resembling the 84 columned cenotaph, which was built by Bhai Deva, the brother of Bheem Rao, Anirudh Singh. There is also a vast reservoir which supplied water to the palace. Today, the extraordinary fort is one of the major tourist attractions of the region.
This is the believed to be finest monument of pure Rajput architecture. The construction of this outstanding palace was started by Maharana Balwant Singh. The palace is approached by a steep, tiled carriage way, through the Hazari Pol or the 'Gate of the Thousand', the Naubat Khana and the Hathi Pol with its ol water clock are some other places of concern inside the palace. Prior permission is required to visit the Palace.


text:
HomeTokyo 2020Let's Learn About Tokyo 2020 Olympics #11
Let's Learn About Tokyo 2020 Olympics #11
In the former articles (#9, #10), I wrote about the venues for the Olympic sports. In this article, you can check the venues for water sports except water polo that I wrote about in the former article (#9).
Venues for Swimming and Diving
Tokyo Stadium will be the venue for swimming, as well as Olympic Aquatics Centre that will be used for diving and artistic swimming, too. Odaiba Marine Park will be used for marathon swimming, which I think is great as Odaiba is a very popular tourist spot that has Rainbow Bridge, resort hotels and so on. Olympic Aquatics Centre is now under construction, and it is planned that it will be able to accommodate 15,000 audiences.
Venues for the Other Sports
Sea Forest Waterway will be the venue for canoe (sprint) and rowing. It is being constructed at a reclaimed area that is surrounded by abundant trees. You can view Tokyo Bay and the urban landscape from there. Canoe Slalom Course will be the venue for canoe (slalom). It is under construction, too. It will be Japan's first canoe slalom course where artificial streams can be created for canoeing competitions. Enoshima Yacht Harbor will be the venue for sailing. It was developed as Japan's first sailing competition venue in Kanagawa Prefecture in 1964. Tsurigasaki Beach Surfing Venue, which is located in Chiba Prefecture, will be the venue for surfing.
Check the map on the official website of The Tokyo Organising Committee of the Olympic and Paralympic Games: https://tokyo2020.org/en/games/venue/olympic/
Hirokazu Kore-eda's "Shoplifters" Wins Palme d'Or at Cannes
Today's Discovery in Uji, Kyoto / The Tale of Genji
Kamo River (Kyoto)
New Year's Visit (Iwashimizu Hachimangu Shrine, Yawata City, Kyoto)


I spent the weekend in the midlands, doing some walking with my Mum and her walking group. Sunday was a real scorcher and we had a long walk by the river Barrow. More a trudge really., with only the odd river cruiser negotiating the locks for company. Like all walks, it turned out to be at least an hour longer than planned. What I mainly took out of it is that there is a big difference between walking up a mountain and walking along a river – one stretch along a river is much like another and you think it's never going to end.
Another thing that ocurred to me as we trudged along is that there are land people and sea people. On a hot day, I'd far rather be on the sea, and get quite frustrated inland. Somehow those small, dusty towns are worse in the sun. To me, it doesn't really matter if you're sailing, windsurfing, surfing or whatever. If you like the sea, that's where you need to be. Luckily, I live in a village by the sea!
Which reminds me, I must buy a dinghy this summer. I keep putting it off, as I travel a lot in summer. Last year, I had a nice windsurfer I got great use out of, until someone stole the board out of my garden. Now it looks like I'll need a whole new rig. Thanks, pal.
After the long walk, there was a deafening country n western band playing in the hotel. Yippe I-ay etc, at full decibels. This seems to be a permanent feature of hotels in the midlands, I wonder why. Something to do with farmers and cowboys? Strange.
The ruined keep depicted here is about a mile from the river, somewhere between Mountmellick and Portarlington. It is where my MacDonnell ancestors used to hang out between approx 1460 & 1640 – making ultimately successful attempts to suppress your ancestors. Sadly, though, like so many Anglo-Saxons sent to "civilise" Ireland, they "went native", James MacDonnell picking the wrong side in the rebellion of 1641 and the castle and lands were forfeit. All seems not to have been entirely lost, though, as a descendant of James is Richard MacDonnell, who was Provost of Trinity around 1850 and is my 4-great grandfather. I was thinking of purchasing the castle and doing it up as a holiday home, but with those huge cracks in the walls it would probably not be worth the trouble and expense.
Sorry – I meant "ultimately UNsuccessful", not "ultimately successful", as I am sure should be clear to all.


text:
Q: Question about number theory - divisibility by $2^n$ ($n$ is large)
Let $a,b,c,d,e$ five natural numbers ($a,b,c,d,e \in N$). We know that $2^{1386} |
 abcde$. (note that $a,b,c,d,e$ are not constant and we can choose
  them).
Find the largest $k \in N $ such that $2^k | a+b+c+d+e$.
note:the question didn't say $abcde = 2^{1386}$ but I think the answer is given by assuming this. So assume $abcde = 2^{1386}$

I know the answer is 280. But I don't know how to get to the answer. the first guess is 277 which $a=2^{277} , b=2^{277} , c = 2^{277} , d= 2^{277} , e= 2^{278}$
but it is not the right answer. I want to know how to get to 280. Please not just give an example and give a solution for finding that specific example or for finding $k = 280$.

A: We can build bigger powers of two from smaller ones, for example:
$$2^6 = 2^5+2^5 = 2^5+2^4+2^4 = 2^5+2^4+2^3+2^3 = 2^5+2^4+2^3+2^2+2^2$$
So in general this kind of 5-term partition gives
$$2^{k+4} = 2^{k+3} + 2^{k+2} + 2^{k+1} + 2^{k} + 2^{k}$$
It's clear that multiplying those $5$ terms of the addition gives $2^{5k+6}$.
Do you see how to apply this to your problem?

A: For every $k\ge 278$ , we can choose $a=b=c=d=e=2^k$, doing the job.
Therefore, there is no largest $k$


Ted Nugent has carved a permanent place in rock & roll history as the ultimate guitar-shredding showman, selling more than 40 million albums, performing over 6,500 high-octane live shows, and continuing to set attendance records at venues around the globe. But that's just the beginning! A lifelong hunter, Ted is lauded for his nonstop promotion of the shooting sports in major media, and is widely regarded as America's Number One Pro-Hunting Voice.


text:
La photoinhibition est le processus biochimique de photoadaptation par lequel un excès de lumière diminue la vitesse de la photosynthèse chez les organismes capables de l'effectuer.

Mécanisme
La plante utilise l'énergie électromagnétique de la lumière du soleil pour arracher des électrons à des molécules d'eau. Ceux-ci sont transférés via une chaîne d'électrons pour être intégrés à des molécules de NADPH. Ceux-ci sont ensuite utilisés pour intégrer le  atmosphérique aux molécules organiques.
En cas d'excès d'énergie lumineuse, le processus de photoprotection permet d'éliminer cet excès sous forme de chaleur, par exemple en modifiant le cortège pigmentaire (chlorophylle a des centres réactionnels et pigments surnuméraires des antennes collectrices. Si ces processus sont insuffisants, des phénomènes irréversibles de photodestruction interviennent : le  n'étant plus présent en quantité suffisante pour que tout le NADPH créé soit utilisé, ce dernier s'accumule. Son accumulation crée une saturation dans la chaîne d'électrons. Les électrons ont alors tendance à réagir avec l' présent dans la cellule, pour former des dérivés réactifs de l'oxygène, qui sont très dommageables pour la cellule, en particulier pour les centres réactionnels des photosystèmes.

Notes et références

Sources
 .

Voir aussi
 Photosynthèse

Photosynthèse

redpajama_set_name: RedPajamaWikipedia


text:
Whats On In Windsor
Things to do in Windsor
Water sports & Theme Parks
Guest Houses B&B
The Savill Garden
Windsor & Royal Borough Museum
Dental Service
All Advertising Services & Options
Windsor News & Events
"What's on in Windsor" is the 'go to' website, packed with information for residents and visitors, to make your time in Windsor an enjoyable. Great ideas on what to do and see, the best places to eat and stay, attractions, events, news and more…
Great advertising opportunities on What's On in Windsor – advertise with us now!
Home Pubs and Bars in Windsor
Pubs and Bars in Windsor
From cool, cutting-edge hangouts to homely, relaxed venues; the city caters to all tastes. From the microbrewery pubs making beer in their basements to bottle shops where you can drink in or take away.
From darts to crib, pub quiz to live music, there really is something here for everybody. Sports fans can catch the big matches here too in the Windsor's pubs.
We offer high quality food with an extensive drinks menu including six rotating cask beers, often from local breweries. We serve over 50 different gins, including our very own Guildhall Island Gin which is made especially for The Queen Charlotte, and named after the cobbled streets in which the pub is located.
All Bar One Windsor
All Bar One Windsor is a stylish city bar where you can catch up with friends, unwind after work or simply find a sophisticated space to indulge in an excellent selection of food and drink.
The Carpenter's Arms in Windsor
You will find The Carpenter's Arms in Windsor within a short stroll of Windsor Castle, Thames Street and Castle Hill - however you won't find another like it. Step in to discover a traditional pub of unique character, revered for its eclectic range of real ales and its quality pub food, which are served, as they should be, with a generous measure of famous British hospitality.
Copyright © 2020 *** What's On in Windsor.com *** All Rights Reserved *** View our Privacy Policy Disclosure and Terms of Use and Disclaimer


text:
import * as cd from 'cd-interfaces';
import * as consts from 'cd-common/consts';
import {
  CdComponent,
  CdComponentFactory,
  getComponent,
  DEFAULT_BOARD_STYLES,
} from 'cd-common/models';
import { INNER_LAYOUT_CONFIG, PADDING_CONFIG, OVERFLOW_CONFIG } from '../../shared';
import templateFunction from './board.template';

export class Board extends CdComponent {
  tagName = consts.DIV_TAG;
  title = 'Board';
  icon = consts.LayerIcons.Board;
  childrenAllowed = true;
  autoAddDefaultProperties = false;

  styles = DEFAULT_BOARD_STYLES.base.style;

  properties: cd.IPropertyGroup[] = [
    { type: cd.PropertyType.BoardSize },
    { children: [PADDING_CONFIG] },
    { children: [OVERFLOW_CONFIG] },
    { type: cd.PropertyType.BoardBackground },
    INNER_LAYOUT_CONFIG,
    { type: cd.PropertyType.BoardPreviewVisibility },
  ];

  template = templateFunction;
  factory = BoardFactory;
}

class BoardFactory extends CdComponentFactory implements cd.IBoardProperties {
  elementType: cd.ElementEntitySubType.Board = cd.ElementEntitySubType.Board;

  constructor(public projectId: string, id: string) {
    super(projectId, id, getComponent(cd.ElementEntitySubType.Board) as Board);
    this.assignFrame(800, 600, 40, 40);
  }
}

redpajama_set_name: RedPajamaGithub


The 859 Egyptian yellow marble vessel sink is made from natural marble. The sink is carved from a large block of marble and hand-polished for a smooth, easy to clean finish. The unique shape of the sink is sure to turn heads in any room. The warm yellow color really stands out and the tan and brown veins that run through the sink add character and texture. Since marble is a natural stone, the details will vary in color and pattern from sink to sink. A matching stone waterfall faucet is available to correspond with this sink. The overall dimensions for the 859 are 19 3/4" x 15" x 5 1/4" and a 21" minimum cabinet size is required. As always, our stone sinks are covered under a limited lifetime warranty for as long as you own the sink.
View the 859 in your home today!
I ordered two Egyptian Yellow Marble Vessel Sinks. The price was great. I received them both in good condition and very quickly. I have already told several people about the web site. Cannot wait to see them in our new master bath.
Produce shipped quickly and arrived on time. Quality of the sink was exactly what I was looking for. Beautiful sink, great price... can beat it!


The only thing better than Sunday brunch is Monday brunch on a three-day weekend. Here are seven places serving up everything from custard French toast to watermelon margaritas this Labor Day to make your end-of-summer hurrah that much sweeter. Read on to find out what's on the menu while you're off the clock.


text:
Search - Locke & Key, Vol 5: Clockworks
Locke Key Vol 5 Clockworks
Author: Joe Hill, Gabriel Rodriguez (Illustrator)
Locke & Key tells of Keyhouse, an unlikely New England mansion, with fantastic doors that transform all who dare to walk through them.... and home to a hate-filled and relentless creature that will not rest until it forces open the most terrible door of them all...! After the gruesome murder of their father, the Locke kids, Tyler, Kins... more »ey and Bode move with their mother Nina to the ancestral family home, Keyhouse. They soon discover that the house is full of secrets when they start finding magical keys which hold impossible powers such as turning people into ghosts, or being able to erase someone's memories. They are not the only ones who know of the keys; a demonic creature known as Dodge is also after the keys, with the goal of opening the Black Door, which will allow the demons of hell to enter our world. The sprawling tale of the Locke family and their mastery of the 'whispering steel' thunders to new heights as the true history of the family is revealed to Tyler and Kinsey. Zack Wells assumes a new form, Tyler and Kinsey travel through time.
Tyler and Kinsey Locke have no idea that their now-deceased nemesis, Lucas "Dodge" Caravaggio, has taken over the body of their younger brother, Bode. With unrestricted access to Keyhouse, Dodge's ruthless quest to find the Omega Key and open the Black Door is almost complete. But Tyler and Kinsey have a dangerous key of their own — one that can unlock all the secrets of Keyhouse by opening a gateway to the past. The time has come for the Lockes to face theri own legacy and the darkness behind the Black Door. Because if they don't learn from their family history, they may be doomed to repeat it, and time is running out
Colonel Adam Crais's minutemen are literally trapped between a rock and a hard place; in the first days of the Revolutionary War, they find themselves hiding beneath 120 feet of New England stone, with a full regiment of redcoats waiting for them in the daylight... and a door into hell in the cavern below. The black door is open, and it's up to a 16-year-old smith named Ben Locke to find a way to close it. The biggest mysteries of the Locke & Key series are resolved as Clockworks opens, not with a bang, but with the thunderous crash of English cannons.
Clockworks [Locke & Key • 5] / graphic format novella by Joe Hill; interior artwork by Gabriel Rodriguez and Jay Fotos
The Locksmith's Son
The Tamers of the Tempest
The Whispering Iron
The Known Keys (Clockworks) [Locke & Key • 5.5] [Excerpts from the Diary of Benjamin Pierce Locke, 1757-1799] / shortfiction by Joe Hill; interior artwork by Gabriel Rodriguez
...to be concluded in Locke & Key: OMEGA
Storytellers: Joe Hill, author, Gabriel Rodriguez, Illustrator. Series edited by Chris Ryall. Collection edited by Justin Eisinger.
. « less
4.3 stars, based on 7 ratings
Publisher: IDW Publishing
Other Versions: Paperback
Members Wishing: 12
Read All 1 Book Reviews of "Locke Key Vol 5 Clockworks"
Karissa E. (ophelia99) reviewed Locke & Key, Vol 5: Clockworks on 8/21/2012 + 2527 more book reviews
Clockworks is the 5th book in the Locke and Key series. It was an absolutely wonderful installment in this series. We finally start to learn the history of the Locke house and the mysterious keys that it hides.
The book starts by going back in time to when a door of evil was discovered and the first of the Locke Keys was made. We then jump back to the current story where things are dire indeed. The characters have found the key that lets them travel back to the past and there they uncover even more secrets behind the history of the Locke house.
This was an awesome book, we learn the whole history behind the Locke household and the mysterious Keys. Many interesting rules about the keys are revealed. This book answers a lot of questions for readers and also brings the story to a peak as things become more dire than ever. I really dont want to say much more than that for fear of spoilers.
As with previous books this book is for adults only; there is a lot of blood and violence in these books as well as other disturbing things. This whole series has been more horror with strong paranormal/fantasy elements.
The characters and plot are both incredibly well done, very gripping, and make the book hard to put down. The illustration is absolutely detailed and beautiful. It is easy to read the characters emotions and easy to follow what is going on.
I personally really enjoyed the way the book went back into history, but those who only enjoy modern horror may not be happy that so much of this book takes place in the past.
Overall I absolutely loved this installment of the Locke and Key series. We learn so much about the history of the Locke house and many of the secrets behind the Keys are revealed. I cant wait to see what the final book in this series will hold...will the Locke children be able to stop the evil that lurks in their house? Highly recommended for fans of horror-fantasy.
Read All Book Reviews of "Locke Key Vol 5 Clockworks"
Science Fiction & Fantasy >> Fantasy >> Sword & Sorcery
Horror >> Dark Fantasy
Comics & Graphic Novels >> Graphic Novels >> Horror
Comics & Graphic Novels >> Graphic Novels >> Mystery


text:
Melt Yourself Down Announce Pray for Me I Don't Fit in.
Home » Melt Yourself Down Announce Pray for Me I Don't Fit in.
Lauded London 6-piece Melt Yourself Down are back armed with a new approach for their fourth studio album Pray For Me I Don't Fit In, released via Decca Records on 18th February 2022.
Created for misfits, by misfits, Pray For Me I Don't Fit In sees Melt Yourself Down embrace a celebratory punk agenda. Having realised they are never going to fit the mould, the group deliberately draw on their myriad influences, speaking all languages musically and lyrically. Led by the potent sounds of Sax pioneer Pete Wareham, the punchy sax hooks pay homage to the traditional horn sections of late 60's early 70's era of Jazz, Soul and Rock n Roll, while showcasing African pentatonic scales and dance-inducing rhythms with raw 70's rock and punk. This album sees vocalist Kushal Gaya celebrate his diversity – tonally, texturally, and emotionally while embracing lyrical depth. Recorded and produced by band favourite Ben Hillier (Blur, Depeche Mode & Nadine Shah), delivering his distinct musical depth, resonance, and dark drive so essential to Melt Yourself Down's sound. This album is the band's most cohesive work to date.
On the ethos of the album, Wareham says: "We don't fit the archetype. This has felt like a problem, for too long, but poetry and art rely on exploiting archetypes. Now we understand that being who we are is all we have and, if that doesn't fit, so be it. I have never felt quite at home, anywhere, sometimes not even inside my own head. We've created music as our home. We want to contribute, but we want to speak to all those who like us, feel outside."
The first single, Pray For Me I Don't fit In, sets the pace and spirit of this new album. Kicking off with a raucous pulsing bass and driving African inspired rhythms, followed by Wareham's unmistakable saxophone hooks. Gaya's vocal range shines through in this track, soulfully melodizing the powerful lyrics of the verses; 'My best friend said am not black enough, my neighbour said am not woke enough …' and defiantly chanting the anthemic chorus; 'Pray for me I don't fit in, something I could never win, everything I find within, helps me keep the outside in'.
Of the single, Gaya adds: "In everything I create there is a tension between wanting to fit in, to feel included and the fear of losing my culture or forgetting where I am from. The refusal to fit in whatever narrative an African man of Asian appearance should play in western society. I started not really caring so much, not second-guessing myself or my vocals so much, which was a huge hurdle to overcome."
Melt Yourself Down are a six-piece, formed in 2012 by sax innovator Pete Wareham. Mauritian/Reunionese vocalist Kushal Gaya and bassist Ruth Goller are the only remaining original members of the band: the current line-up includes saxophonist George Crowley, with Adam Betts and Zands Duggan on drums and percussion. Melt Yourself Down rose from the ashes of Wareham's previous outfit Acoustic Ladyland. Wareham's work reinventing, defying, and embracing extensive musical influences has seen him collect numerous accolades and acknowledgements, including the BBC Jazz Award, The Paul Hamlyn Award and multiple Mercury Prize nominations, and this pioneering work has paved the way for many acts in the new British jazz wave. The band will be embarking on a 14-date tour across the UK in March 2022, tour dates and ticket information below.
Title track from the album and first single 'Pray For Me I Don't Fit In' is out now and is available to listen here
Tags Melt Yourself Down Pete Wareham Pray For Me I Don't Fit In
LOSKI SHARES NEW PROJECT 'CENSORED'
Mercedes-benz Fashion Week Russia: New Designers, Cultural Unity and Digitalization


text:
WATCH | Trio win chemistry Nobel for lithium-ion battery
Three researchers won the Nobel Chemistry Prize for the development of lithium-ion batteries, paving the way for smartphones and a fossil fuel-free society.
London train attack: What we know
Members of the emergency services work near Parsons Green underground tube station in west London. (AFP)
WATCH: Scenes from London 'terror incident' at Parsons Green
Passengers were seen badly burned and covered in blood, after what Met police are treating as a "terrorist incident" on a London Underground train on Friday. Watch. WATCH
WATCH: Scenes from London 'terror incident' at Parsons Green watch
UPDATE: Police declare reported explosion on London subway a 'terrorist' incident
Second man arrested after Buckingham Palace sword attack
London - More than 20 passengers were injured, some suffering severe burns, in an early morning explosion on a London Underground train in what police described as a "terrorist incident," the fifth attack in six months in Britain.
Emergency services were called around 8:20 am (07:20 GMT) after the explosion at Parsons Green station in a leafy southwestern suburb which police counter-terror chief Mark Rowley said had been caused by an "improvised explosive device." Police immediately declared an investigation into a "terrorist incident." One Twitter user who posted pictures of a smouldering white bucket in the carriage described a "fireball" which "flew down (the) carriage."
Prime Minister Theresa May was preparing to chair an emergency cabinet meeting while her foreign minister, former London mayor Boris Johnson, appealed for calm as did current mayor Sadiq Khan.
Months of attacks
Britain has suffered months of repeated attacks, killing 35, since a lone attacker in March mowed down pedestrians and stabbed a police officer outside parliament before police shot dead Khalid Masood, a Muslim convert with a history of violence. He is believed to have acted alone.
In May, Salman Abedi, a Briton of Libyan origin, blew himself up outside a pop concert in Manchester, killing 22 - a third of them children. Islamic State claimed responsibility as well as for a June attack near London Bridge which left eight dead. Police shot dead three attackers after they went on the rampage.
Who was behind the bombing?
There were no immediate claims of responsibility. US President Donald Trump blasted "loser terrorists" behind the latest attack as "sick and demented people" and blamed the internet as the perpetrators' main recruitment tool.
The National Health Service put the injured toll at 22. The London Ambulance service said 18 people were taken to four London clinics and the NHS added four passengers made their own way to hospital. Witnesses reported several passengers on the train had been "badly burned" by the blast. One journalist at the scene reported some victims' "hair coming off."
Read more on: london | security
Kimberley Jobs
HOUSES FOR SALE IN Paarl, Val De Vie Estate
Houses R 18 000 000


The Reese Technology Center is home of the National Wind Institute at Texas Tech University. Recently, the NWI has partnered up with Western Texas College for an hours-transfer program that is set to last through 2018..
In a ceremony hosted at Texas Tech, an agreement that allows Western Texas College students to transfer their coursework to Tech in order to receive a Bachelor of Science in wind energy was signed by representatives from both colleges.
The ceremony was hosted on Nov. 10.
The educational partnership is part of an administrative initiative to make Tech's National Wind Institute the premier wind energy studies program in the United States and also included an agreement to last through 2018, Andy Swift, associate director of education for National Wind Institute, said.
The educational plan allows students who have earned an Associate of Arts degree in general studies-science at Western Texas College to transfer their coursework to Tech in order to earn a Bachelor of Science in wind energy. Tech's relationship with Western Texas College has been integral to the growth of National Wind Institute's wind energy education program, Swift said.
More than 180 students are now majoring in wind energy. The program has a job placement rate of 80 percent, and the United States' renewable energy sector is steadily growing, Swift said.
Students at Western Texas College will also be able to transfer additional coursework, and Tech will accept both the transferrable core curriculum and other coursework within the Texas common course numbering system, Marina Gonzales, Western Texas College wind energy curriculum specialist, said.
Tech is home to the only bachelor's degree in wind energy in the entire country, Gonzales said. Tech has aided Western Texas College in creating five wind energy courses at the community-college level, which were the equivalent of lower-division undergraduate courses in a bachelor's degree.
All of the wind energy courses at Western Texas College are offered both online and in the traditional classroom setting, according to the Western Texas College website. Employers will be looking to hire as many as 300,000 employees in the next 15 years.
Indeed, the demand for wind energy specialists from the renewable energy industry was one of the reasons why the academic partnership was formed between the two institutions, Gonzales said. Potential opportunities for employment include a career as a wind farm developer, wind project site manager and wind field operations manager, among others.