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Limit my search to Chromosomes and Gene Expression
Chromosomes and Gene Expression
Viruses: A frameshift in time
The efficiency with which ribosomes shift reading frames when decoding viral RNA may change over the course of an infection.
Martina M Yordanova
Pavel V Baranov
Martina M Yordanova,
Pavel V Baranov ,
School of Biochemistry and Cell Biology, University College Cork, Ireland;
When an RNA virus infects a cell, ribosomes inside the cell decode the genetic information in the virus's RNA to produce proteins, which are then used to make more viral particles. A single-stranded RNA molecule consists of a sequence of nucleotides that the ribosome reads three at a time. Each triplet, or codon, codes for either an amino acid (the building blocks that form proteins), or signals for the ribosome to start or stop reading the RNA sequence. Therefore, each nucleotide sequence can therefore be 'read' by ribosomes in three different ways, or 'reading frames', depending on which nucleotide the ribosome starts reading from. Additionally, an 'open reading frame' or ORF is a sequence of nucleotide triplets that code for amino acids located between two stop codons in the same reading frame.
Almost all cellular proteins are encoded in a single reading frame, with only rare exceptions (Baranov et al., 2015). Viruses, however, often break this rule in a process termed 'programmed ribosomal frameshifting' (Firth and Brierley, 2012; Atkins et al., 2016). This mechanism occurs at specific locations in the nucleotide sequence called frameshift sites, where a proportion of the ribosomes translating the RNA will shift back or forward one nucleotide and start decoding a different reading frame. Meanwhile, the rest of the ribosomes continue reading the original frame. Thus, the same segment of an RNA molecule can be read to produce two protein molecules with distinct amino acid sequences simultaneously.
It is unclear exactly why viruses employ programmed ribosomal frameshifting. One suggestion is that this mechanism allows for a more compact organization of genetic material. Another is that frameshifting could be used for setting a specific ratio between different viral proteins. Most commonly, ribosomal frameshifting occurs during the synthesis of viral polyproteins, long amino acid chains that are processed into smaller proteins with distinct functions. The advantage of organizing protein synthesis in this way is that only one RNA molecule is needed to encode multiple proteins. However, if all these proteins were synthesized as a part of a single polyprotein, they would occur strictly in a one-to-one ratio after being processed. This would be wasteful, since these proteins are needed in different quantities.
So how could the optimal proportions of these proteins be achieved? The low efficiency frameshifting mechanism solves the problem. Proteins that the virus needs in large quantities are encoded early in the sequence in an open reading frame herein referred to as ORF1A, while proteins that the virus requires in lower quantities are encoded in a different but overlapping downstream reading frame, herein referred to as ORF1B (Figure 1). ORF1A is decoded according to standard rules, producing a shorter version of the viral polyprotein. ORF1B, on the other hand, is only read by the ribosomes that change reading frame at the frameshift site between ORF1A and ORF1B, resulting in a longer polyprotein.
Schematic representation showing how RNA is decoded in the vicinity of the frameshift site between two open reading frames, ORF1A and ORF1B.
Top: most ribosomes (yellow) decoding ORF1A terminate at the stop codon (red arrow), release the protein (not shown) and dissociate from the RNA (gray curve). A small proportion of ribosomes, however, shift frames to decode ORF1B. The ribosome at the frameshift site is outlined with a fuzzy cloud. Center: the density of ribosome footprints (the lines under each of the ribosomes) revealed by ribosome profiling maps to the positions occupied by ribosomes on the RNA molecule. The ratio between the ribosome footprint density at ORF1A and at ORF1B can be used as a measure of frameshifting efficiency. Bottom: schematic of the three possible reading frames in a molecule of RNA, each represented by a bar and denoted by –1, 0, and +1. The clock-like nature of the frameshift site drawing alludes to the temporal regulation of frameshifting as revealed by Cook et al.
This type of frameshifting is sometimes referred to as canonical due to its common occurrence in RNA viruses. It was originally assumed that the ratio of products generated from ORF1A and ORF1B was fixed throughout the virus's time in the cell (Jacks and Varmus, 1985). Now, in eLife, Ian Brierley, Andrew Firth, Ying Fang and colleagues – including Georgia Cook (University of Cambridge) as first author – report evidence suggesting that this ratio changes over the course of infection (Cook et al., 2022).
The team (who are based at various institutes in the United Kingdom, the United States and China) studied how viral gene expression changes during porcine reproductive and respiratory syndrome virus (PRRSV) infection. To do this, Cook et al. used a technique called ribosome profiling to map which parts of the virus's RNA sequence were being translated by ribosomes at any given time (Ingolia et al., 2009). These mappings, called ribosome footprints, revealed several new ORFs that encoded previously uncharacterized viral protein products.
Ribosome profiling can also be used to compare how efficiently different proteins are synthesized. For example, in the PRRSV genome the density of footprints mapped to ORF1A is higher than the footprint density at ORF1B. This happens because only a small proportion of the ribosomes reading ORF1A shift reading frame and proceed to ORF1B (Figure 1). By calculating the ratio of footprint densities between the two open reading frames it is possible to estimate frameshifting efficiency.
The PRRSV genome is known to contain two frameshift sites: the canonical site between ORF1A and ORF1B, which is used by many viruses, and a second, rarer frameshift site in ORF1A that results in the production of a shorter polyprotein. The genome of a related virus, called the encephalomyocarditis virus, has been shown to have a similar secondary frameshift site that is stimulated by a viral protein (Napthine et al., 2017). The concentration of this viral protein was found to increase over the course of an infection and cause more ribosomes to shift to the other reading frame. However, by measuring the efficiency of both frameshifting sites in PRRSV, Cook et al. showed that this temporal change is not limited to the protein-stimulated frameshifting, but also occurs in the canonical site between ORF1A and ORF1B.
This finding challenges the current paradigm that regards the canonical frameshifting between ORF1A and ORF1B as a mechanism that enables a fixed ratio between polyprotein products. The temporal change detected in PRRSV suggests that the efficiency of frameshifting may also be altered in other viruses over time. If so, it would be interesting to determine what factors mediate the regulation of the frameshifting event between ORF1A and ORF1B.
An open question that remains is how changes in frameshifting efficiency along the course of an infection relate to the virus's virulence and transmissibility. It is possible that changes in efficiency are simply due to alterations in the infected cell that make ribosomes more prone to shifting to another reading frame. However, it may be that regulating the efficiency of frameshifting is beneficial for the virus. Alternatively, the antiviral response of the host may induce frameshifting to alter the ratio of viral proteins and negatively impact the virus. Indeed, it has been previously reported that the formation of viral particles can be disrupted by altering frameshifting efficiency (Dulude et al., 2006).
Whatever the case, the search for cellular factors responsible for changes in frameshifting has already begun (Riegger and Caliskan, 2022). The identification of these factors will provide researchers with new targets for modulating frameshifting efficiency in viruses, potentially revealing new ways to fight off viral infections.
Atkins JF
Loughran G
Bhatt PR
Firth AE
Baranov PV
(2016) Ribosomal frameshifting and transcriptional slippage: from genetic steganography and cryptography to adventitious use
Nucleic Acids Research 44:7007–7078.
https://doi.org/10.1093/nar/gkw530
Yordanova MM
(2015) Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning
Nature Reviews Genetics 16:517–529.
Cook GM
Brown K
Shang P
Soday L
Dinan AM
Tumescheit C
Mockett APA
Fang Y
Brierley I
(2022) Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Dulude D
Berchiche YA
Gendron K
Brakier-Gingras L
Heveker N
(2006) Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1
Virology 345:127–136.
https://doi.org/10.1016/j.virol.2005.08.048
(2012) Non-canonical translation in RNA viruses
The Journal of General Virology 93:1385–1409.
https://doi.org/10.1099/vir.0.042499-0
Ingolia NT
Ghaemmaghami S
Newman JRS
Weissman JS
(2009) Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
Jacks T
Varmus HE
(1985) Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting
Napthine S
Ling R
Finch LK
Jones JD
Bell S
(2017) Protein-directed ribosomal frameshifting temporally regulates gene expression
Riegger RJ
Caliskan N
(2022) Thinking outside the frame: impacting genomes capacity by programmed ribosomal frameshifting
Frontiers in Molecular Biosciences 9:842261.
https://doi.org/10.3389/fmolb.2022.842261
Martina M Yordanova is in the School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
Pavel V Baranov is in the School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
p.baranov@ucc.ie
Version of Record published: April 11, 2022 (version 1)
© 2022, Yordanova and Baranov
arterivirus
porcine reproductive
respiratory syndrome virus
PRRSV
ribosome profiling
programmed ribosomal frameshifting
subgenomic mRNAs
Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Georgia M Cook, Katherine Brown ... Ian Brierley
Research Article Updated Apr 11, 2022
The arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the swine industry worldwide. Here we apply ribosome profiling (RiboSeq) and parallel RNA sequencing (RNASeq) to characterise the transcriptome and translatome of both species of PRRSV and to analyse the host response to infection. We calculated programmed ribosomal frameshift (PRF) efficiency at both sites on the viral genome. This revealed the nsp2 PRF site as the second known example where temporally regulated frameshifting occurs, with increasing −2 PRF efficiency likely facilitated by accumulation of the PRF-stimulatory viral protein, nsp1β. Surprisingly, we find that PRF efficiency at the canonical ORF1ab frameshift site also increases over time, in contradiction of the common assumption that RNA structure-directed frameshift sites operate at a fixed efficiency. This has potential implications for the numerous other viruses with canonical PRF sites. Furthermore, we discovered several highly translated additional viral ORFs, the translation of which may be facilitated by multiple novel viral transcripts. For example, we found a highly expressed 125-codon ORF overlapping nsp12, which is likely translated from novel subgenomic RNA transcripts that overlap the 3′ end of ORF1b. Similar transcripts were discovered for both PRRSV-1 and PRRSV-2, suggesting a potential conserved mechanism for temporally regulating expression of the 3′-proximal region of ORF1b. We also identified a highly translated, short upstream ORF in the 5′ UTR, the presence of which is highly conserved amongst PRRSV-2 isolates. These findings reveal hidden complexity in the gene expression programmes of these important nidoviruses.
Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes
Myeongjune Jeon, Goowon Jeong ... Ilha Lee
To synchronize flowering time with spring, many plants undergo vernalization, a floral-promotion process triggered by exposure to long-term winter cold. In Arabidopsis thaliana, this is achieved through cold-mediated epigenetic silencing of the floral repressor, FLOWERING LOCUS C (FLC). COOLAIR, a cold-induced antisense RNA transcribed from the FLC locus, has been proposed to facilitate FLC silencing. Here, we show that C-repeat (CRT)/dehydration-responsive elements (DREs) at the 3′-end of FLC and CRT/DRE-binding factors (CBFs) are required for cold-mediated expression of COOLAIR. CBFs bind to CRT/DREs at the 3′-end of FLC, both in vitro and in vivo, and CBF levels increase gradually during vernalization. Cold-induced COOLAIR expression is severely impaired in cbfs mutants in which all CBF genes are knocked-out. Conversely, CBF-overexpressing plants show increased COOLAIR levels even at warm temperatures. We show that COOLAIR is induced by CBFs during early stages of vernalization but COOLAIR levels decrease in later phases as FLC chromatin transitions to an inactive state to which CBFs can no longer bind. We also demonstrate that cbfs and FLCΔCOOLAIR mutants exhibit a normal vernalization response despite their inability to activate COOLAIR expression during cold, revealing that COOLAIR is not required for the vernalization process.
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
Fernanda M Bosada, Karel van Duijvenboden ... Vincent M Christoffels
Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation (AF). We deleted the conserved mouse orthologues of two independent AF-associated genomic regions in the Tbx5 locus, one intronic (RE(int)) and one downstream (RE(down)) of Tbx5. In both lines we observed a modest (30%) increase of Tbx5 in the postnatal atria. To gain insight into the effects of slight dosage increase in vivo, we investigated the atrial transcriptional, epigenetic and electrophysiological properties of both lines. Increased atrial Tbx5 expression was associated with induction of genes involved in development, ion transport and conduction, with increased susceptibility to atrial arrhythmias, and increased action potential duration of atrial cardiomyocytes. We identified an AF-associated variant in the human RE(int) that increases its transcriptional activity. Expression of the AF-associated transcription factor Prrx1 was induced in Tbx5RE(int)KO cardiomyocytes. We found that some of the transcriptional and functional changes in the atria caused by increased Tbx5 expression were normalized when reducing cardiac Prrx1 expression in Tbx5RE(int)KO mice, indicating an interaction between these two AF genes. We conclude that modest increases in expression of dose-dependent transcription factors, caused by common regulatory variants, significantly impact on the cardiac gene regulatory network and disease susceptibility.


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Baseball card stories from Steve Sparks
Steve Sparks pitched nine seasons in the major leagues for five teams. His best season was 2001, when he went 14-9 with a 3.65 ERA for the Tigers, leading the American League with eight complete games. Now an account executive at Flagstone Lending in Houston and the pregame and postgame TV analyst for the Houston Astros, he kindly answered my questions about baseball cards.
" I have a deep fondness of baseball cards that lure me to the time I truly fell in love with the sport. I had a morning newspaper route from 3rd grade until I went to college. A very large portion of the money I earned went to the dime store. Topps was the only company for years that produced cards, and that was perfect. The packs were inexpensive, and it was easy to keep track with all the cards with their checklists. I even got a box of cards for my birthday on multiple occasions. At least twice a year, I would empty all my cards throughout my room to re-categorize. I would often get lost on one card for thirty minutes memorizing his stats.
You can imagine it was a big thrill for me when I actually saw my first Major League card. It was the winter after my rookie year and I was on the Brewers winter caravan throughout the state of Wisconsin, promoting our team. My wife always used to kid me about sticking out my tongue when I was concentrating to which I vehemently denied, but sure enough, my first baseball card proved her right. I laughed for that reason when a fan showed me that card, but I felt a tremendous burst of pride to be included with all those great players I collected my entire life.
One of my favorite cards is the one where I'm stretching before a game and waving with a goofy grin on my face. That kind of epitomizes my personality and my career! The other card I enjoyed was an insert to Cracker Jack. There was only a few players selected for that issue, and I was somehow included. I've only seen it a couple of times.
I'm currently in the mortgage business. My job has provided enough flexibility to stay in the game, though. For the past six seasons, I have worked as the TV analyst for the pregame and postgame shows of the Houston Astros. I can't imagine a time where baseball will not be a part of my life, and it started with those cards."
Glenn Wilson on baseball cards
Outfielder Glenn Wilson played ten seasons in the major leagues for Detroit, Philadelphia, Seattle, Pittsburgh and Houston. His best season was 1985, when he hit .275 with 14 HR and 102 RBI for the Phillies, earning an all-star appearance. Now the owner of Glenn Wilson Baseball in Houston, he kindly answered my questions about baseball cards.
"I really have never collected cards. When I was a kid my brother collected them but I thought they would make for a cool sound in my bicycle spokes. I do not have a favorite card of myself but have several I do not like. I think card collecting is a good hobby and see where it could be fun trying to get them autographed. There is one funny story I have about cards and autographs. In Philadelphia 1984 I remember Mike Schmidt signing all of Pete Rose cards and pictures since Pete had been released and signed by Montreal. The funny part was you could not tell the difference. Mike's Pete Rose signature looked just as if Pete had signed it."
Thanks! Here is a card of him from my collection, from 1985 Fleer.
Brian Stavisky on baseball cards
Outfielder Brian Stavisky played in the A's, Angels and Phillies organizations from 2002 to 2010, hitting .305 with 77 HR and 423 RBI in 773 games. Now a Financial Advisor Associate at Morgan Stanley Smith Barney, he kindly answered my questions about baseball cards.
"The one story/memory that comes to mind with my Topps/Bowman baseball cards is how cool it was to hear about people from my small hometown, Port Allegany, PA, buying packs at local stores and finding my cards in them. I thought it was really cool to have a card deal with Topps/Bowman in 2005, where I signed several thousand for distribution in regular packs throughout the country. Sometimes people I knew opened packs to find my cards mixed in with the cards of major league all-stars and future hall of famers. It was pretty awesome for both myself and my hometown community.
This is my favorite card of myself, although some of the other ones look pretty cool, too:
I no longer collect baseball cards, but I did for several years growing up. From around ages 8 to 17 I collected cards every chance I could. I haven't looked at my collection in a while, but as I get older it will be a fun thing to look back on. Also, most of my friends growing up collected cards, too, and we would often take the cards we had and create lineups for backyard wiffleball games and homerun derbies. Those were some great times!"
Thanks! I don't have that card, but here is one I do have from 2005 Topps Heritage.
Some Yankee cards from Cards on Cards
Got some cool Yankee cards from Madding of Cards on Cards. He's a Cardinal fan whose second favorite team is the Yankees; I'm a Yankee fan whose second favorite team is the Cardinals. We both had lousy LCS's - having experienced both kinds, I'd rather my team get swept then blow a 3-1 lead.
The cards include my first card of Ichiro Suzuki as a Yankee. It always looks weird when they omit his last name on a card, and doubly weird when the card design has a particular place for the last name.
Here are some other cool cards of the type of player the Yankees need to get back to - the kind that can shorten their swing and/or take a walk instead of swinging from their heels no matter the situation/count/pitcher.
Baseball card story from Anthony Manahan
Infielder Anthony Manahan played in the Mariners and Phillies organizations from 1990 to 1996, hitting .276 in 600 minor league games. Now an insurance professional in Arizona, he kindly shared with me this baseball card story.
"I have a fresh card story. I was with an old teammate last week named Rich Amaral. Rich told me that I am actually pictured on the back of one of his cards as him. I need to find that card."
Thanks! Here is the card, from 1996 Collector's Choice.
Here is the front - as you can see, Amaral and Manahan don't look too similar.
Finally, here is an actual card of Manahan.
Baseball card story from Greg Hunter
Infielder Greg Hunter played in the Mariners and Twins organizations from 1990 to 1995. In 284 games he hit six home runs and stole 29 bases. Now a scout for the Mariners, he kindly shared with me this baseball card story.
"Best story would have to be the fact that I ended up in the 1991 Classic Best set after hitting .213 with 1 HR and 13 RBI's for the Bellingham M's of the Northwest League the previous year. I have no idea how I ended up in that set. That card gets sent to me occasionally for signature. I am now a pro scout with the Seattle Mariners but started working in the front office in 1996. The year we took Jose Cruz Jr. in the first round (1997 I believe), I was showing Jose Cruz Jr's family around our spring training complex in Peoria, Arizona. Most notably Jose Cruz Sr who had a wonderful 19 year career in the Major Leagues. As we are walking between the Minor League fields a fan comes running up to us to ask if he can get a signed card. Jose Cruz reaches out to take the card from the guy, but the autograph seeker turns to me and says oh sorry I was looking to get Mr. Hunter's signature and hands me the Classic Best 1991 card to sign. That unknowing fan definitely missed out on an opportunity but gave me instant credibility with Jose Sr.
The 1991 Classic Best is the favorite of mine as I still get an occasional request for signature. I collected cards but was never an avid collector so I do not have any favorites of others that come to mind."
Player Profile: Brian Barber
I have 20 cards of Brian Barber. This one is from 1994 Classic.
Playing career: Brian Barber pitched for the Cardinals in 1995 and 1996, and the Royals in 1998 and 1999. In 26 games, he was 5-8 with a 6.77 ERA.
Where he is now: A scout for the Yankees.
Google Autocomplete results: He is third when you type Brian Barb, between Brian Barbour Twitter, referring to an account covering UNC athletics, and Bryan Barber Film Director, director of the movie Idlewild. When you google Brian Barber the first entry is not the ballplayer but a graphic designer.
Coming up next: The next profile will be Bret Barberie.
Player Profile: Dan Barbara
I have one card of Dan Barbara, from 1989 Star.
Playing career: Catcher Dan Barbara played in the Mariners organization from 1988 to 1990. In 197 games he hit .249 with 0 HR and 55 RBI.
Where he is now: Anyone know where Dan Barbara is now?
Google Autocomplete results: He is sixth when you type Dan Barbar, between Dan Barber Ted Talk, an interview with a chef, and Dan Barber WSJ, a Wall Street Journal article about a chef. When you google Dan Barbara there are no entries for the former Mariner minor leaguer, though there is one for a former replacement player with the Phillies.
Coming up next: The next profile will be Brian Barber.
Player Profile: Rod Barajas
I have nine cards of Rod Barajas. This one is from 2010 Topps Update Gold.
Playing career: Rod Barajas has been a semi-regular catcher for the past fourteen seasons, compiling between 300-430 at bats in eight of the last nine seasons. In five of those seasons he has hit at least 15 home runs.
Where he is now: This season he played in 104 games for Pittsburgh, hitting .206 with 11 HR and 31 RBI.
My memories: He's one of those backup catchers whose name you always hear but I don't have any specific memories.
Google Autocomplete results: He is second when you type Rod B, between Rod Blagojevich, the former governor of Illinois, and Rod Burks, a porn star. Another prominent Rod Barajas is Director of Sales at Lead Audit.
Coming up next: The next profile will be Dan Barbara.
Player Profile: Travis Baptist
I have four cards of Travis Baptist. This one is from 1993 Fleer Excel League Leaders.
Playing career: Travis Baptist pitched in thirteen games for the 1998 Twins, going 0-1 with a 5.67 ERA.
Where he is now: A pharmacist at a Walgreens in Jacksonville.
Google Autocomplete results: Travis Baptist Baseball is sixth when you type Travis Bap, after Travis Baptist School, a school in a church in Corpus Christ, TX. When you google Travis Baptist, the ballplayer is the second result, after the church.
Coming up next: The next profile will be Rod Barajas.
Wow, six runs in four games. One run in the entire series that did not come off of a homer. Meanwhile, Miguel Cabrera slugged the ball like it was his wife and Delmon Young slugged it like it was a Jew. Maybe next year the Yankees should sign some alcoholics and thugs? And Girardi really has to change this awful managerial philosophy:
Anyway, is is time to finally put away the notion that the Yankees are one of baseball's elite teams? They have won one pennant in the last nine years. That is as many as the Colorado Rockies or Houston Astros. Teams that have won more:
Cardinals -3
Phillies - 2
Rangers - 2
Red Sox - 2
Tigers - 2
The Giants might join this list later this week. Otherwise, the Cardinals will win their fourth pennant in the last nine years. If they do, then they have to be considered the team of the 21st century so far. The Cardinals have been my favorite National League team since the '80s, so I'll definitely be rooting for a 2nd-Wild-Card world champ!
Baseball card story from Scott Anderson
Scott Anderson pitched ten years of professional baseball and reached the major leagues on three separate occasions – 8 games for the 1987 Rangers, 4 games for the 1990 Expos, and 6 games for the 1995 Royals. Now a Senior Territory Manager for Lifecell in Oregon, he kindly answered my questions about baseball cards.
"I don't collect cards and never really got into the memorabilia craze. I can only say that my Fleer card with the Expos jogs a nice memory each time I see it. It was taken at Wrigley the day I was called up from Indianapolis. The day before, the Expo bullpen was decimated so I got the call to fill in as the only live arm in the pen that day. Kevin Gross started the game and gave up 6 runs in 5 innings of work and I entered the game with bases loaded, nobody out in the 6th to face Andre Dawson. It had been a few years since I'd pitched in the big leagues and while that moment was not the perfect opportunity to reacquaint myself to the big leagues, I stood behind the mound that night before my first pitch and was so calm and relaxed. I remember specifically knowing that it would be a life long memory.
In spite of the fact that my 1-2 sinker was hit just under the glove of Tim Wallach for a double to left, clearing the bases, I finished the game, pitching well the rest of the way. Which in the end led to further opportunities with the Expos down the road.
My career fell short of my personal goals overall but I have a few pearls that I can hang onto."
Almost done...
That the Yankees are setting a franchise worst for postseason batting average (.200 going into tonight's game) should be no surprise - I predicted this before the playoffs even started. This team of wild swingers has no ability for situational hitting. In trying to think of a silver lining, I realized this: Mariano Rivera's injury did not hurt the Yankees in October, as many people thought back in May. (Of course, now that I write this, the Yankees will take a lead into the ninth and Soriano will blow the save.)
Player Profile: Floyd Bannister
I have 44 cards of Floyd Bannister. This one is from 1983 Topps.
Playing career: Floyd Bannister was the #1 pick in the 1976 draft, and made it to the majors the next season with Houston. After two seasons in Houston he was traded to the Mariners for Craig Reynolds. In 1982 Bannister led the American League in strikeouts. The following season he signed with the White Sox as a free agent and helped lead them to the playoffs, going 16-10 with a 3.35 ERA. As the White Sox descended into mediocrity so did his won-loss records, though his other numbers stayed decent.
My memories: I remember him on the bad White Sox teams of the mid-80s, and didn't realize that he was actually a very good pitcher, just had the bad luck to pitch for bad teams.
Interesting facts: Bannister put up insane numbers in his senior year of high school, going 15-0 with a 0.00 ERA in 112 innings, striking out 196 and walking 17.
Where he is now: He manages Loft 19, the photography studio owned by his son, former major leaguer Brian Bannister.
Google Autocomplete results: He is fifth when you type Floyd Ba, between Floyd Banner Gangster, better known as Pretty Boy Floyd, and Floyd Bailey, a US Navy veteran who died in August. There do not appear to be any other prominent Floyd Bannisters.
Coming up next: The next profile will be Travis Baptist.
Jeter and Meatballs
In the 1980s, the Yankees only had one good pitcher, Dave Righetti, and their pitching staff was known as Righetti and Meatballs. Now, they have one good hitter - Derek Jeter - and he's not playing again this year. (I'm not counting Raul Ibanez, who isn't going to get a hittable pitch from a righty again.) The best thing for the Yankees at this point might just be to get shut out again tomorrow and Wednesday, to really emphasize what kind of housecleaning is in order. The hitting coach, Kevin Long, has go to go, the Yankees have to let Swisher walk, see if they can get anything of value for Curtis Granderson, and put Joe Girardi on notice that things have got to change. A good team doesn't get shut out for 20 of 21 innings by a team's #3 and #4 starters and their shaky bullpen.
Posted by Bo at 11:59 AM 2 comments:
How low can you go?
No, not bad enough to go down quietly in a 4-0 defeat. You have to get everyone's hopes up by tying up the game in the ninth. But then you go right back to your anemic ways and lose in twelve innings. And, to top it off, your best player breaks his ankle. Well, this will all be over on Wednesday after they are swept.
Well, the Yankees got past Baltimore. In fact, all of the "Cinderella" teams (Orioles, A's, Nationals) turned into pumpkins as soon as they hit the Division Series. Let's see how the Yankees do against a legit playoff team - and on zero rest, to boot.
The Yankees could barely scratch out any runs against the Orioles, and even with A-Rod benched, will probably show a similar ineptitude against Detroit. Time for the pitching staff, starting with Andy Pettitte tonight, to show that their performance against Baltimore was for real, and not just a fluke.
Now no Yankees can hit
I may have been wrong with the volume of home runs Hughes would allow, but I was right about the importance. He gave up one little solo homer but that was enough to break the back of the Yankees' anemic offense.
CC Sabathia goes to the mound in a few hours knowing he has to pitch a shutout for the Yankees to even remotely have a chance to win this game.
Ahhh, they'll probably just lose 10-9, just to shake things up.
At least one Yankee can hit
So, after Raul Ibanez hit the game-tying home run in the ninth inning, the next eight Yankees made out - all too inevitable with this team in the clutch. So, as Ibanez steps into the batters box to lead off the twelfth, I tell my wife, "If Ibanez doesn't hit a home run here, the Yankees are dead." The words were barely out of my mouth when he hit a blast into the upper deck to win the game for the Yankees!
Unfortunately, Phil Hughes, who gives up a lot of home runs, is pitching tonight in Yankee Stadium, which is a home run ballpark, against an Oriole lineup that hits a ton of home runs. I would say the over/under on home runs by Baltimore tonight is seven. Mark Reynolds could hit three.
Another garage sale haul
For the second time in three weeks I went to a garage sale only because it was a few weeks away from my house. Again I walked away with a huge box of cards from the late 90s and early 00s. Cards from that area used to be pretty rare to see at garage sales, but I guess now people who were card-buying kids those days are now out of college, moving out of their parents houses and getting rid of them. Just to pick out one card, I'll highlight this awesome Rondell White card:
By the way there was a ton of 1995 Donruss (mostly series two) and lots of 1995 Ultra (including a bunch of Gold Medallion parallels), 2003 Donruss, 2000 Topps, 1999 Upper Deck MVP, and 1999 Upper Deck Victory so I've got some cards in all of those sets to trade.
There was also a smattering of 1980s cards, including a surprising number of good ones, all of which are up for trade:
1985 Donruss Dwight Gooden (rookie card)
1986 Donruss Lenny Dykstra (rookie card)
1986 Donruss Tom Seaver
1990 Donruss Mark McGwire
1985 Fleer Tony Gwynn
1987 Fleer Wally Joyner (rookie card)
1990 Fleer David Justice (rookie card)
1979 Topps Jim "Catfish" Hunter
1984 Topps Wade Boggs
1986 Topps Len Dykstra (rookie card)
1987 Topps Rafael Palmeiro (rookie card)
1988 Topps Barry Bonds
Posted by Bo at 4:50 PM 1 comment:
Typical Yankee Game
Boy, that was about as cookie-cutter a 2012 Yankee game as you could get last night. Score in the first inning and then basically get shut out the rest of the game - check. Waste numerous opportunities, outhitting the opponent but getting outscored - check. The usual suspects making outs in key spots (in this case, Swisher and A-Rod most egregiously) - check. Waste a good performance by the starter - check.
The worst part is, I knew this would happen, and yet I was still angry and disappointed when they lost. Clearly, I haven't resigned myself to their fate in my heart, even if I have in my head.
Sweep averted
Well, I was wrong about the Yankees getting swept, which is good, though I'd feel better if the Yankees didn't always lose series where they won Game 1. (In five of their last six playoff series losses, the Yankees have won Game 1.) Buck Showalter certainly helped the Yankees, bringing in his closer in a non-save situation, which he promptly blew up. But most important is the pitching of CC Sabathia. With the Yankees' inconsistent offense, they'll go as far as their pitching can take them.
One last tidbit: The Yankees have never faced Baltimore in a division series before. Here are the Yankees records in division series, team by team:
vs. Twins - 4-0
vs. Oakland - 3-0
vs. Texas - 3-0
vs. Seattle - 0-1
vs. Angels - 0-2
vs. Indians - 0-2
vs. Tigers - 0-2
The Yankees feast against three teams, and famine against the rest. On which side will Baltimore end up?
Playoff preview
This is the seventeenth postseason appearance for the Yankees in the last eighteen years, and I have never been more pessimistic. The Yankees haven't been swept in a postseason series since 1980, but I think they have a really good chance to do that this year. All season, the Yankees have not been able to get a clutch hit with a man on base. The only way they score runs is if the pitcher makes a mistake and they hit it out. That doesn't happen nearly as often in the playoffs. The fact that they won 95 games says more about their competition then it does about their skill level. This is the worst Yankee team, talent-wise, since 1992.
My prediction: Granderson, Swisher and Teixeira go a combined 2-33, stranding 24 runners on base. The Yankees lose all three games by one or two runs. In Game 3, they are losing 6-1 in the bottom of the ninth, and lose 6-5 as ______ strikes out with runners on first and third to end the game.
The Yankees' only hope is that Showalter is as stupid in 2012 as he was in 1995, when he brought in Jack McDowell in relief in Game 5 on one days rest, when Mariano Rivera and Andy Pettitte were rested and available in the bullpen.
Cards from Scott Crawford
Got some great cards in a trade with Scott Crawford. They were all from late-90s to early-00s Fleer. The scariest one was definitely Zombie Brooks Robinson.
The Yankees will be playing that scary Baltimore team in the playoffs. Let's hope the Yankees can avoid those zombie Orioles, while catching some of that World Series Fever from Bernie Williams.
Player Profile: Brian Bannister
I have three cards of Brian Bannister. This one is from 2007 Topps.
Playing career: A self-described "prototype #4 starter," Brian Bannister had an excellent rookie season for the Royals in 2007, going 12-9 with a 3.87 ERA. Unfortunately, he followed that up with three seasons of sub-.500 records and high ERAs, and retired before the 2011 season.
Where he is now: He is an avid interest in photography, and owns Loft 19 Studios in Phoenix.
My memories: I remember him with the Mets; was surprised to see he only pitched six games for them. I thought he was there for a couple of seasons. I also remember how he was considered to be one of the smarter players in the game, one who paid attention to his own statistics.
Interesting facts: Son of former major league pitcher Floyd Bannister.
Google Autocomplete results: He is first when you type Brian Ban, ahead of Brian Banks NFL, referring to the football player. Another prominent Brian Bannister is an anesthesiologist in Syracuse, NY.
Coming up next: The next profile will be Floyd Bannister.
Cards from Night Owl
Got a bunch of cards in a trade with Night Owl. I was just expected some hits to my Stadium Club want lists, and got a bunch of really nice looking cards from those sets.
However, he surprised me and sent a bunch of random Yankees too! Here are a couple of those that he sent me that really caught my eye:
Babe looks so awkward and uncomfortable. And who's that guy behind him? Thanks, Night Owl!
Luis Alicea on baseball cards
Luis Alicea played thirteen seasons in the major leagues, coming up with the Cardinals in 1988, and last playing with the Royals in 2002. Now the Director of Baseball Operations at the Elev|8 Sports Institute in Delray Beach, FL, he kindly answered my questions about baseball cards.
"I don't have any particular stories about any cards, but I always have a preference for the action cards. I like the cards that were taken during actual play, specially when I am jumping over a player as he is trying to break a double play. I like to collect cards, especially Roberto Clemente. I have several of him as well as other former MLB players. I am actually starting to look for some of my old cards, so I can give my younger son, he is 4 years old and the other day he was so happy when he got his first set of baseball cards not knowing that his father has cards of his own. When I showed him my cards, his faced lit up and he took them to school so he could show his school teachers."
Thanks! You can find his work address in the link above if you want to send him any cards you might have. I am going to.
Brian Barton on baseball cards
Outfielder Brian Barton has played professionally since 2005, reaching the major leagues with both the Cardinals and the Braves. This year he played for the Southern Maryland Blue Claws, hitting .311 with 7 HR, 58 RBI, and 23 SB. He founded the (XY)∞ Foundation (boys and girls times infinity) to expose inner city youth to travel, business ownership, public speaking and community action. He has recently written a motivational book called Mindset, and also has a blog where he discusses various political and intellectual topics. He kindly answered my questions about baseball cards.
- Do you have any stories about cards of yourself or of other players?
Well, a funny story is that when I was with the Cardinals there was a guy named Brian Barden on my team, so when I got my first rookie card I was like "Hey, this is not my signature." Turns out they switched my signature with Brian Barden's signature so all of my rookie cards that have replica signatures printed are not my signatures.
- Do you have a favorite card of yourself or of another player?
I definitely think my card with the Braves was my favorite, because even though I was there for one day it was a reminder of my return to the big leagues.
- Do you collect baseball cards?
I used to collect cards when I was younger so I have a collection of a few thousand baseball cards.
Thanks! I don't have those cards, but here is one I do have from 2008 Stadium Club.
Paul Wilmet on baseball cards

redpajama_set_name: RedPajamaCommonCrawl


text:
from libcrypto import xor
from libcrypto import freq_score
from binascii import hexlify

def main():
    input = "1b37373331363f78151b7f2b783431333d78397828372d363c78373e783a393b3736"

    print("Possible Solutions...\n")
    solutions = []
    for i in range(1,int("ff",16)):
        key = bytes({i})
        xor_bytes = xor(bytearray(key),bytearray(bytes.fromhex(input)))

        try:
            xor_string = xor_bytes.decode("ascii")
        except UnicodeDecodeError:
            next
        solutions.append([key, xor_string, freq_score(xor_string)])

    solutions.sort(key=lambda x: x[2], reverse=True)
    solutions = solutions[:1]

    for solution in solutions:
        print("[+] Key: {0:#x} | Text: {1}".format(bytes({solution[0]}), solution[1]))

if __name__ == "__main__":
    main()

redpajama_set_name: RedPajamaGithub


text:
Ohio News Briefs
Bill makes Ohio back-to-school tax holiday an annual event
COLUMBUS, Ohio (AP) — The Ohio sales tax holiday that benefited back-to-school shoppers the last several years will become an annual, three-day event under a bill passed by state lawmakers.
During the first weekend in August, shoppers wouldn't pay sales tax on qualifying purchases, including clothing items under $75 and school supplies under $20.
Lawmakers backing the legislation say the tax holiday encourages families to shop in the state and helps Ohio businesses and other industries that support the retail segment.
The measure now heads to the governor's desk.
This year's tax-free weekend will begin Aug. 3.
155-foot-tall SkyWheel comes to Cincinnati's Coney Island
CINCINNATI (AP) — A giant Ferris wheel will take a spin in Cincinnati starting in late May.
Officials say the 155-foot (47-meter) SkyWheel will be ready for riders when Coney Island opens for its 132nd season on May 26. It will remain in operation through July 8.
The SkyWheel features 36 six-person gondolas. Each 10-minute ride includes four rotations and views of the entire park and the Ohio River.
Coney Island officials say the ride will be lit at night and visible from miles around.
Tickets for the ride are $5 and will be available for purchase online.
OSU and NFL quarterback now an Ohio deputy sheriff
PORT CLINTON, Ohio (AP) — The redshirt freshman quarterback who helped lead Ohio State University to victory in the 2015 national championship game is getting fitted for a uniform of an entirely different kind.
The Port Clinton News-Herald reports Cardale Jones was made an honorary Ottawa County sheriff's deputy last summer. Jones spoke at a father-son church banquet in Ottawa County on Friday.
Sheriff Steve Levorchick says he and Jones, a Cleveland native, have become good friends and that he loves him "like a brother."
Levorchick says Jones will serve as a special ambassador to help the Sheriff's Office bond with young people. He says that when Jones shows up in the uniform he's being fitted for, children will realize "cops aren't necessarily bad."
Jones is on the roster of the NFL's Los Angeles Chargers.
College to offer new programs to address regional job needs
CINCINNATI (AP) — An Ohio college will be offering new degrees designed to fill in-demand jobs in the region.
Cincinnati State Technical and Community College says it's creating four-year bachelor's degree programs in land surveying and in culinary and food science. The Cincinnati Enquirer reports both programs were approved by the state Department of Higher Education last week. Classes in those programs could be offered as early as this fall.
The programs address regional workforce needs. Jobs in those fields are in high demand but aren't being filled.
A Cincinnati State spokesman says graduates could immediately make between $45,000 and $70,000 annually and in some cases even more. He noted that surveying jobs typically pay higher salaries than culinary jobs.
Columbus police body cameras should be rolled out by June
COLUMBUS, Ohio (AP) — Ohio's largest city says the process of outfitting police officers with body cameras is ahead of schedule and should be completed by early summer.
Columbus officials say more than 850 city officers already wear body cameras and a total of 1,300 should be in use by late June. The Columbus Dispatch reports the city began purchasing the cameras in late 2016.
City officials say initial plans called for getting cameras to officers throughout the department by year's end, but implementation has gone more smoothly than expected.
Assistant Director of Public Safety George Speaks says the project is under budget.
Speaks says the Columbus Police Training Academy has expedited training on how to operate the cameras using instructional videos.
A police union official says officers have become accustomed to the technology.
Propeller signed by Orville Wright heading to Denver museum
DAYTON, Ohio (AP) — A wooden propeller signed by airplane inventor Orville Wright is leaving Ohio's National Aviation Hall of Fame to go on loan at a Colorado museum.
The National Aviation Hall of Fame inside Wright-Patterson Air Force Base near Dayton has owned the Wright Model K propeller since it was donated in 2004. The Dayton Daily News reports the propeller will be on display at the Wings Over the Rockies Air & Space Museum in Denver for five years.
NAHF President Michael Quiello says displaying the artifact in Denver will expand NAHF's national brand recognition and help tell the story of the birthplace of aviation to a new audience.
A museum crew recently flew to Dayton to pick up the propeller.
Body found in garbage can ID'd as missing Ohio woman
CLEVELAND (AP) — Authorities say the body of a woman found in a garbage can at an abandoned house in Cleveland is a 31-year-old woman reported missing earlier this month.
Cleveland.com reports the Cuyahoga County Medical Examiner's office has identified the woman as Miriam Johnson, of Cleveland Heights. She was reported missing in Cleveland Heights by her mother on March 6.
A cause of death hasn't been determined. No arrests have been made.
Johnson's body was found Thursday on Cleveland's east side.
Cleveland Heights Police Chief Annette Mecklenburg said Friday that detectives have been following leads since Johnson was reported missing.
A sister said the last time their mother saw Johnson was when she dropped her off at home Feb. 25.
Police: Officers kill woman during SWAT standoff in Ohio
COLUMBUS, Ohio (AP) — Police in Ohio's capital city of Columbus say a woman who shot at officers during a SWAT standoff has been killed.
Columbus police in a statement Saturday afternoon identified the woman as 25-year-old Kaitlin Marie Demeo, of Columbus. She was fatally shot around 8 a.m. Saturday during a standoff that began several hours earlier.
Police spokesman Sgt. Dean Worthington says officers initially responded to a home after a report of shots being fired. Worthington says Demeo had barricaded herself inside the home, armed with a rifle.
Worthington says Columbus SWAT and Negotiation Team officers tried to persuade Demeo to surrender.
He says Demeo fired at officers from an upstairs window at around 8 a.m., prompting two SWAT officers to kill her.
It's the fourth police shooting in Columbus this year.
Hi! A visitor to our site felt the following article might be of interest to you: Ohio News Briefs. Here is a link to that story: https://www.urbanacitizen.com/news/61583/ohio-news-briefs-408


text:
March 26 - Coronavirus (COVID-19) Live Golf News
Live Golf News Updates for March 26
10:00 p.m. EST, March 26, 2020
Our live coverage of the coronavirus has moved here.
Here are the latest golf news and updates for Thursday, March, 26. (All times Eastern)
6:44 p.m. -- Teaching pros across country adjusting to life away from the range Golf Channel reports.
6:18 p.m. -- Clark County, Ohio golf courses to remain closed amid stay-at-home orders in Ohio.
5:25 p.m. -- In Massachusetts, all public and private golf courses are suspended, but landscaping has been deemed an essential service, so grounds crews can maintain the courses.
5:17 p.m. -- Connecticut courses remain open, with precautions.
3:42 p.m. -- Golf Digest puts out a list from GCSAA on state-by-state breakdown of where golf's allowed and where it isn't.
1:18 p.m. -- Palm Beach County, Fla., courses are among the latest to suspend operations as part of stay-at-home orders.
9:43 a.m. -- Here's the latest from Canada.
Well intentioned statement from key Canadian golf stakeholders on best defense measures against #COVIDー19. pic.twitter.com/zooe6cVeup
— Rick Young (@YoungerGolf) March 26, 2020
9:37 a.m. -- Australia's 1,500 courses remain open with restrictions, including one buggy per passenger, no rakes and no open clubhouses.
8:05 a.m. -- One-third of all private golf clubs have closed, according to Golf Inc Magazine. The number is expected to climb as the virus spreads and more state and local governments issue stay-at-home orders. Currently, 63% of clubs have reported reduced operations, and the cumulative hit to the business is estimated at $31 million.
Coronavirus Golf Live Updates
https://www.googletagmanager.com/ns.html?id=GTM-MD2PGD5 height="0" width="0" style="display:none;visibility:hidden"
US cases grow: There are now more than 85,300 cases of the novel coronavirus in the US, according to the CDC.
Talk to us: Do you have a story about the coronavirus or want to share what golf means to you? Share them with us.
Stay updated: We'll provide you with all the latest golf news surrounding the coronavirus as it becomes available.
As information about the coronavirus pandemic rapidly changes, Golf News Hub is committed to providing the most recent data in our coverage. Some of the information in this story may have changed after publication. For the latest on COVID-19, readers are encouraged to use online resources from CDC, WHO, and local public departments.
RELATED LIVE NEWS
May 29 - Coronavirus (COVID-19) Live Golf News
Live Golf News Updates for May 29
May 23 & 24 - Coronavirus (COVID-19) Live Golf News
Live Golf News Updates for May 23 & 24


text:
Michigan Sees Largest Measles Outbreak Since 1991
Photo by Illustration Justin Sullivan/Getty Images
The Michigan Department of Health and Human Services has confirmed five additional measles cases, bringing the state total to 39 for this year.
The newly confirmed cases were all in Oakland County, bringing the case count to 38 in Oakland County and one in Wayne County.
Infected individuals range in age from 8 months to 63.
In response to the latest confirmed cases, the Oakland County Health Division hosted a special measles vaccination clinic on Saturday in Southfield.
Oakland County has known exposure sites listed online and more may be identified as further information becomes available.
This is the highest number of measles in the state since 1991 when 65 cases were reported.
Additionally, the Indiana State Department of Health has confirmed a case of measles unrelated to the Michigan outbreak in its state with exposure locations in Sturgis, Michigan.
Individuals who visited the Holy Angels Catholic Church on Nottawa St., San Miguel Grocery on Jacob St. or Walmart Supercenter on Centerville Road on March 31st may have been exposed to measles and urged to watch out for signs of the disease.
Individuals who were possibly exposed are advised to watch for symptoms 21 days after exposure. Initial symptoms include high fever, cough, and runny nose. Additionally, tiny white spots on the inner cheeks, gums, and roof of the mouth can occur two to three days after initial symptoms begin. Within three to five days a red rash that is raised and blotchy will usually start on the face, spread to chest, arms, and legs.
If symptoms develop, it is crucial to call ahead to the healthcare provider so they can take precautions to prevent exposure in other individuals.
Measles is a vaccine-preventable disease that is spread by direct person-to-person contact, and through the air by a contagious person sneezing or coughing. The virus can live for up to two hours in the air where the infected person coughed or sneezed.
The MMR vaccine is effective within 72 hours of exposure and treatment is effective within 6 days of exposure for high-risk individuals. High-risk individuals include pregnant women, those who are immune-compromised, or individuals born before 1958. A single dose of measles vaccine protects about 95 percent of children, but after two doses, almost 100 percent are immune.
In 2018, Michigan had 19 cases of measles which was the most reported in the state since 1994. From 2001 to 2012, the average number of measles cases reported nationally per year was about 60.
So far this year, there have been 387 cases of measles confirmed in 15 states.
For more information about Michigan's current measles outbreak, visit Michigan.gov/MeaslesOutbreak. For more information about measles, visit CDC.gov/measles.
Filed Under: measles, Michigan Department of Health and Human Services, vaccine
Categories: Michigan, News


text:
/ Home / Courses / Postgraduate / MSc Global Health / Global health
This programme will introduce you to the concepts of global health at a policy and grass roots level. We will support you in exploring current global health challenges, and the importance of global health issues – their economic, environmental and social consequences – and the policies and strategies to mitigate these.
In our increasingly interconnected world, global health and the health of populations is a major challenge. This module provides you with the knowledge and expertise to critically examine the multi-sectoral nature of global health problems and global policy responses required to protect and promote the health of populations in both a local and global environment.
The module is taught in Plymouth over two three day blocks in the autumn term. There are a variety of speakers and seminars led by experts in the field. Group activities and a field trip to explore the global health issues locally within Plymouth ensure you leave with a comprehensive understanding of the key concepts of Global Health. The course also benefits from links to the University of Plymouth Global Health Collaborative and research from across the university that links to Global Health.
Dr Tara Harrop gives an introduction to the global health module on the MSc Global Health programme.
David Barkwill - graduate
This module provides the perfect introduction to global health, starting with the core principles and progressing to their real-life application. I particularly enjoyed the class debates and stories from professionals within the field. The course also brings together like-minded individuals, both students and lecturers, which both inspired and motivated me. For my final project I wrote a health partnership proposal for an FGM clinic in London and a Medical Centre in the Massai Mara, Kenya. After completing the assignment, I passed on information from my literature search on initiating belief change in Massai communities to a friend who works as a Doctor in the Kenyan Medical Centre. He recently contacted me to let me know that he had used this information in his latest anti-FGM campaign and had observed positive initial results.
Global Health Collaborative
FRESH AIR international research programme
Institute of Health and Community
Sustainable Earth Institute
…"There is a drought?"
How do we effectively communicate the current devastating spiral of the drought and famine in The Horn of Africa?
Dr Lucy Obolensky discussed the worst drought it has seen since 1945 in The Horn of Africa.
Global Health – related news
GP for Sir David Attenborough inspiring others into the career 23 May 2019
Using art to tackle lung disease: Illustration students making an impact in Uganda 28 March 2019
University spinout receives £1.2million government funding to tackle antimicrobial resistance 4 February 2019
Orthopaedic project delivers vital help to Kenya 20 December 2018
£2 million research funding to address chronic lung disease in developing world 9 August 2018


This week my assignment in my photography class is either a high or low key assignment. I think I am drawn to dark things because all of my shots have been low key so far! I am a dork and want to get my stuff right, because my class is a film class not digital so I can ruin my assignment if I am not careful. So what I do is take the picture with my digital camera and try to get what I am looking for and then I take a couple with the film camera and hope that they work out. I won't develop this roll until Monday, so I am hoping my assignment will turn out. The assignment was to shoot something that has at least 90% low key (darker tones) and 10% of the photo can be in a higher key (lighter tones).
These were what I got from my digital camera, I turned them to black and white since that is what I will get on the film!
This was supposed to be a little creepier than it turned out but I like it!
This is probably my favorite, it fits the assignment pretty well.
Our wedding rings! The metal provided a great highlight on this one.
This doesn't work for the assignment and was one of the pictures I used to know I didn't have my camera on the right settings but I just love it!!! I think it is so cool! My husband makes a great model and is so patient with me!
This one also doesn't fit the assignment but Royce is just too cute!
I love looking at your photos and seeing how things are going. Keep up the good work!


text:
Sub judice
There are rules about what you can say while a trial is ongoing. As Tommy Robinson found out.
American rules about what is sub judice might be different.
A trial in the Senate might not be a trial in this same sense.
Someone, somewhere, should tell us. For this could, potentially, be a dangerous thing to be saying:
Donald Trump is clearly guilty.
That it's Amanduh does mean that it's possible she's been badly briefed as to the law…..
previousPersonal Injury Settlements: How Do We Evaluate Pain and Suffering?
nextNo shit
21 thoughts on "Sub judice"
jgh January 23, 2020 at 5:06 pm
Interesting that Senators are bid silence on pain of imprisonment. Why isn't that extended outside the sitting?
Flubber January 23, 2020 at 5:07 pm
Shes a fucking idiot. A d just because Adam bug eyed cunt Schiff tells more lies than a 2nd hand car salesman doesnt make it so.
dearieme January 23, 2020 at 5:12 pm
Of course Literally Hitler is guilty. He invaded Poland, damn it.
BraveFart January 23, 2020 at 5:39 pm
Apart from the criminal position, it may also be libellous. What with insane US damages awards that could be far more dangerous than any offence?
Tim Worstall January 23, 2020 at 5:45 pm
American libel awards are trivial by comparison with English. Rare to see one that goes into 5 figures US dollars.
And public figures have an extremely difficult time claiming libel. If you're a "public figure" – itself an elastic concept – then you have to prove malice. Not just that this was libel but also that they absolutely meant it and did it in order to harm you.
It's exceedingly rare for a public figure to be able to win a libel suit over there.
Dennis, Tiresome Denizen of Central Ohio January 23, 2020 at 6:06 pm
Septics view sub judice differently from wogs.
First amendment trumps sub judice in the case of the general public, which, unfortunately, includes Amanduh.
rhoda klapp January 23, 2020 at 6:19 pm
By coincidence, I've jusr read this at Chiefio's blog.. Hat tip to Taz.
Media now forces me to endure an additional step before reading. If the journo is female – check if she has children. No children? She's likely out of her mind – not worth the trouble to read.
Diogenes January 23, 2020 at 6:26 pm
Curious, isn't it, that Biden is now saying he would not allow any of his family to benefit from his high office if he were to become President…it's almost as if he suspects the game is up for him
The Other Bloke in Italy January 23, 2020 at 6:32 pm
Dennis (He of Many Hats) is correct in principle, but US juries can be generous.
Perhaps, this is why young Nick Sandmann's first target, CNN I think, settled so quickly. 25mil is a figure I have seen.
Andrew C January 23, 2020 at 6:50 pm
"First amendment trumps sub judice"
A legal game of Top Trumps……..
Not sure if you have Top Trumps card games over in the US?
When playing the "Tyrants and Dictators" version, having a hand full of socialist leaders gave you a good chance of winning. They're just so far ahead in the "own citizens murdered" category.
Pcar January 23, 2020 at 7:38 pm
@rhoda
Children don't help – see Sara Vine (Mrs Gove) in DM
@The Other Bloke in Italy
CNN settles $275M lawsuit with Covington student Nick Sandmann
https://www.youtube.com/watch?v=qjXFDQJA7CY
Dennis, Mad Hatter January 23, 2020 at 7:52 pm
For septics the issue all revolves around whether the receiver of the abuse fits the legal definition of a "public figure". Clearly THE DONALD fits that definition. Equally clearly, Nick Sandmann doesn't.
Agammamon January 23, 2020 at 8:37 pm
There are almost no rules about what you can say about or around a trial here.
Basically – don't talk about 'jury nullification' (its legal, judges like to pretend its not) and don't talk about the case around the jurors (nothing will happen to you but it might get a juror replaced).
Its not even (legally speaking) libel/slander here.
And, of course, the Senate's impeachment 'trial' isn't a trial by any other standard – criminal or civil. 'Charges' brought here don't have to be crimes, they could just be 'we don't like your face'. If enough of them find him 'guilty' of having a non-likable face, then he's out on his ear.
Which is also why, for example, the impeachment 'charge sheet' doesn't actually list any charges. No focus and no way for the defendant to know what he has to defend against. Evidence is whatever the Senate agrees is evidence. Rules are whatever the Senate agrees on – and they've been different at every impeachment trial.
Bloke in North Dorset January 23, 2020 at 9:11 pm
Other Bloke in Italy,
I don't think Sandmann would count as a public figure, at least before the incident and he's also a minor.
CNN got off lightly, let's hope the rest of the shits get stung badly.
Gamecock January 23, 2020 at 9:28 pm
[not too fast]
'The House-appointed managers, let by Rep. Adam Schiff, D-Calif., spent most of the day arguing that trials work better when the evidence is actually presented'
[not a duplicate]
So why didn't Schitt gather that evidence when he was running the show in the House? It's HIS job to present the evidence they found. Schitt said they had enough evidence to impeach, so he wrapped it up and sent the papers to the Senate. Sorta.
'as opposed to Senate Majority Mitch McConnell's plan to stifle as much of it as possible.'
He runs the Senate; Schitt doesn't. Schitt knew this before the impeachment show ever started in the House.
He claimed two months ago he had the evidence. Now he wants to call witnesses, presumably to get the evidence he said he already had. He lied before. And he's lying now. It's what he does.
[testing]
So this is a political show, calculated to help the Dems with the 2020 election. More for the Senate than the presidency. Their presidential primary clown show will produce no candidate for president. Their convention will have to select someone. They'll probably go for Bloomberg. For his money. Talking up a rinky dink small town gay mayor is an act of decadence. By the convention they'll realize they can't afford such. Bloomberg will lose the election – as will any other Democrat – but at least he has $2B US to share. Pete has nothing.
Don't think Michelle Obama. She will stay out of it. Losing is no way to break into politics.
I assume the Dems know all this. But they often have a problem with reality.
'White House lawyers have no defense for Trump.'
Defense for what? There are no charges! "Abuse of power" is not a crime – it's a feeling. And disrespecting Congress is what the vast majority of Americans do.
Let me show you how profoundly stupid Marcotte is:
'cannot muster anything resembling an actual defense of Trump's impeachable offenses, those trying to blackmail the Ukrainian president into smearing his political opponents on TV and then stonewalling Congress over it.'
Ukraine is not in the impeachment papers. She believes that which is demonstrably not real.
Flubber January 24, 2020 at 3:15 am
"Abuse of power" is not a crime – it's a feeling. And disrespecting Congress is what the vast majority of Americans do.
They're alleging Abuse of power for Trump seeking relief from the courts.
Its total panto bollocks.
And Schiff is a world class cunt.
Bloke in North Dorset January 24, 2020 at 7:15 am
Perhaps, but Impeachment isn't about crimes its intent was always meant to be for political use:
First among those myths is the notion that impeachment is reserved solely for criminal abuses of office. Perversely, as the power of the office has grown, that misconception has ensured that the federal official with the greatest capacity to do harm now enjoys stronger job protection than virtually any other American.
But the remedy James Madison described as "indispensable . . . for defending the community against the incapacity, negligence, or perfidy of the Chief Magistrate" isn't limited to violations of the law or abuses of official power. As the 1974 House Judiciary Committee report on "Constitutional Grounds for Presidential Impeachment" put it, impeachment was "intended to reach a broad variety of conduct by officers that is both serious and incompatible with the duties of the office." "A good magistrate will not fear [impeachments]," Massachusetts' Elbridge Gerry insisted at the Constitutional Convention, and "a bad one ought to be kept in fear of them." Through the exercise of the "sole Power of Impeachment," the House can call even the most powerful federal officer to account. That power should never be invoked lightly, but neither should Americans fear to wield it, should it become necessary.
As to Trump's impeachment its bollocks and I hope it comes back to bite them. They were always going to impeach him from the moment he was elected, it was just when and on what charges. Dems claiming it was a national emergency because he was a threat to their sanity and then delayed it sort of proves the point.
Ljh January 24, 2020 at 10:00 am
I am convinced that this is theatre to keep the Dems busy while Durham and Huber mine away for evidence and indictments(over 145 000 sealed indictments currently, usual no for comparison is 5 000 on pacer.gov). One can guess what will trigger it but Sidney Powell, Flynn's lawyer, has started the process of revealing corruption and downright lying in the FBI; Peter Schweizer's latest book reveals just how large a family enterprise followed when he was VP and that the other Dem candidates are also enthusiastic troughers; Giuliani is itching to haul out his evidence trove from Ukraine, and GOK what Obama was up to in Iran with his pallets of cash(btw he eased up restrictions on Soleimani in 2014 to which the UN Security Council strongly objected).
True, BiND. In the end, an impeachable offense is what the House says it is. So it will always be political.
"Dems claiming it was a national emergency" is a shiny object to get people to think it wasn't just raw politics, and not just Orange Man bad.
The press, and their surrogates in the Democrat Party, have engaged in a massive attack of false characterization of Trump. It is reasonable for the party faithful to demand impeachment, as Trump has done all these horrible things. Except he hasn't. The press lies.
The dumbass Dems impeach Trump on nothing, having been SET UP BY THE PRESS!
Of course I hope this turns out really bad for the Dems. Bad enough that they split from the press. That divorce could return the press to doing their job, instead of colluding with Leftard politicians.
John B January 24, 2020 at 1:35 pm
… guilty of being President while being Donald Trump.


I just love the practicality of these! Kids can actually put books away on shelves like these, because it's a lot easier. Plus, they can see the books which makes them more inclined to read them.
Ooo, I love it too, we might just have to try this!


Aug 12, 2009 · این ضربه گیر در زیر عرشه ی کشتی قرار می گیرد تا از تجهیزات و خدمه . مهندسی معدن. . belleville spring.
The bonnet contains a spiral or a belleville spring . با فشار اروپا تجهیزات . مارپیچی یا بهار belleville .
standards are considered as benchmarks for quality of Disc Springs and Belleville Washers worldwide. There are very few companies in the world, .
Spring washers designed as per DIN 2093 standards in inches and metric dimensions. . These springs are also commonly known as Belleville springs.
Belleville Washer Products - Century Spring Corp.
Belleville Washers - Disc Springs - Spring Washer .
Disc springs, or Belleville washers, are used singly, or in stacks, to achieve desired load and travel. Century Spring stocks a large Belleville washer inventory.
Home » Resource Library » Belleville Springs » Belleville Spring Specifications. Belleville Spring Specifications.


Play DVD, DivX, (S)VCD, MP3-CD, WMA-CD, CD(RW) & Picture CD Dolby Digital for ultimate movie experience Dolby Digital for ultimate movie experience Because Dolby Digital standards, the world's leading digital multi-channel audio standards, make use of the way the human ear naturally processes sound, you experience superb quality surround sound audio with realistic spatial cues. 12-bit/108 MHz video processing for sharp, natural images 12-bit Video DAC is a superior Digital-to-Analogue Converter that preserves every detail of the authentic picture quality. It shows subtle shades and smoother graduation of colours, resulting in a more vibrant and natural picture. The limitations of the standard 10-bit DAC become particularly apparent when it is used with large screens and projectors.


Do you or your spouse commute to the city? What has your experience been with the commute?
I commute to the city on average 2 or 3 times a week. I see patients on the upper east side every Wednesday, but find myself back in the city a few other times per week to film TV segments, speak with beauty editors, train dermatology residents at Mount Sinai hospital or meet with brands that are developing cutting edge skincare technologies. When I'm filming GMA, I usually hit the road around 4:30am so it takes under an hour to get to the Times Square studio. If I'm traveling during rush hour, it can take 1.5 hours each way. On the weekends, we love to head to the city to catch a show, visit a museum, or visit friends, and the commute is usually under an hour.
Tell me more about your Dermatolog practice.
As the Medical Director of Integrative Dermatology, Aesthetics & Wellness at Advanced Dermatology, P.C., I take a 360 degree approach to the health of my patients' skin. I believe that your skin is a window into your overall health. In my practice, I offer the most cutting edge cosmetic procedures available including lasers, microneedling, and fillers, but I also address chronic skin conditions like acne, rosacea, eczema, and even premature aging, through advocating specific lifestyle changes including diet, sleep techniques, stress management, and exercise. I help my patients to address the underlying cause of these conditions to get right to the root of the issue for lasting, healthy skin. I see patients both in Briarcliff Manor as well as the upper east side of NYC.
You published a book recently. Tell us more about your book.
Yes! My book, The Beauty of Dirty Skin, was truly a labor of love – and the culmination of ten years of my life's work and research. At the heart of my book is the concept that healing and nourishing our skin's "microbiome" is critical to sustain healthy, glowing skin. Skin conditions like eczema, rosacea, psoriasis, and acne might appear to be surface problems, but I have found that these conditions are much more than skin deep. Amazingly, there are more than one trillion bacteria in the skin, originating from approximately one thousand different species. When our skin's healthy microbiome is disrupted by harsh cleansers and other abrasive skincare products, this discontent results in breakouts, rosacea flares, psoriasis, eczema, and even sensitive skin. On the other hand, when our "good" warrior bugs are healthy, they can fight infections, fight environmental damage, boost our immune system, and keep our skin hydrated and radiant! Many people don't realize that your gut, brain and skin can communicate. My book explains that the alliance between your gut, brain, and skin – called the gut-brain-skin axis – is the soul of healthy skin. And, to put this science into an actionable game plan to help achieve YOUR healthiest skin, I designed a 21 Day Plan which focuses on each of these areas – gut, brain, and skin – to heal your skin from the inside out and from the outside in.
I've heard you are a dermatologist who loves the sun? Explain!
Yes! I absolutely love going on warm vacations with my daughter and husband and we have a waterfront summer home with a rack filled with kayaks and paddleboards. I never shy away from swimming in the ocean or pool and I love to feel the warm sun on my skin. For me, it's all about balance and taking steps to protect my skin in order to stay healthy while living my life! I think it's unrealistic to hide under an umbrella all the time or fear playing with my daughter in the water because of the sun. I wear UPF swimsuits, my daughter wears rash guards – there are some really cute and flattering mommy and me options that are sun protective on the market today (Teaser – I might have a really beautiful capsule collection of sun protective bathing suits in the works!) I wear sunscreen. I wear sunglasses. I eat a diet rich in antioxidant-packed foods that offer natural sun protection and I take a sun protective supplement called Heliocare. Most of all, I savor every minute of feeling the sand between my toes.
You have amazing skin. Can you tell me more about your skin care routine?
Skincare is so incredibly personal – what works wonderfully for one person can actually cause a reaction and sensitivity in another! Personally, I use gentle, pH balanced cleansers, a gentle retinol serum, and I love a good Vitamin C serum. I exfoliate – very gently – twice per week only! I wear a moisturizer with broad spectrum sunscreen daily, rain or shine. I am always testing the latest innovations in skin care and attending conferences to meet the scientists and CEOs behind these concepts and products. I am asked about my skincare recommendations all the time, so I share my favorite products – and the science behind them – on my Dr. Whitney's Picks page. My social media channels (@drwhitneybowe on IG, FB and TW) are another way that I share my opinions and work with my audience and I love to answer the questions raised on my channels to empower more people to achieve their healthiest, radiant glow!
Which Westchester School Districts Provide School Bus Transportation?
Westchester: Buyer's Market or Seller's Market?
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Clarion Call is Lone Wolf Tribe's (LWT) performance cycle exploring the legacy of warfare and the need for non-violence in our world. Through clowning, magic, pantomime and street based endurance performances lasting up to 3 days, Clarion Call's boldly yet silently exposes the greatest source of violence in our world- war and the military establishments that perpetuate it.
LWT often collaborates with Veterans for Peace (VFP) a non-profit educational and humanitarian organization of vets dedicated to increasing public awareness of the true costs of war.
Clarion Call offers a meditative alternative to the military's adventurous vision of war, which they hope to market to a new generation of combat soldiers. We do this by poetically transforming military iconography – particularly the practice of bayonet training-- which was "designed to undo socialization and eradicate the reluctance of human beings to kill each other," says Richard Kohn, professor of military history at the University of North Carolina at Chapel Hill.
Centered around a large weather resistant banner depicting a bayonet training posture to engage (kill) the enemy, hang several human-sized, target "dummies" with bull's eyes stitched to their chests; many more lie on the ground—ripped and torn. Sitting within this environment is a veteran character, symbolizing the enormous suffering from all wars. The dissonance of this utterly weary vet lost in his "thousand yard stare", juxtaposed with the poster image (see work sample), speaks volumes without uttering a single word. This alone can last for hours/days as an art installation, whether inside a venue or on a city sidewalk.
Eventually, (while a VFP member gives a lecture), the veteran character begins sewing the target's wounds. Offering kindness instead of continued aggression, a cycle of violence is symbolically broken by transforming the paradigm from enemy to friend.
Clarion Call counters the military's advertised war glamour by providing a reality check about the astronomical suicide rate among veterans, the psychological trauma countless service men and women will be forced to deal with for the rest of their lives, and the devastating environmental and societal costs that come with institutionalized aggression.
CLARION CALL is LWT's radical street theatre series about the true costs of war.
Shared as a roving pantomime performance (lasting up to 3 days at a time in all types of weather) on city sidewalks, in public parks, parade marches and at military bases, our poetic message is: peace is possible-- we only have to choose it.
Inspired by old-time "tramp" clowns Otto Griebling & Emmett Kelly as well as WW2 cartoonist, Bill Mauldin, who realistically portrayed the gritty reality of infantrymen, LWT artistic director, Kevin Augustine embodies the "Hobo Grunt," a hybrid character—part sad tattered clown, part weary homeless veteran.
Augustine's portrayal is also influenced by Buddhist principles of compassion for all suffering beings as well as the suicide of his father—a Marine who took his own life when Kevin was 12 years old.
Honoring the clown's pantomime tradition while also acknowledging a soldier's directive to not question orders, the Hobo Grunt works entirely in silence and is the central link between all of the performance components in CLARION CALL.
Supported by a two-year grant from the Jerome Foundation as well as the Puffin Foundation, CLARION CALL has collaborated since 2012 with Veterans for Peace, Brooklyn for Peace and Grannies for Peace speaking out against the greatest source of violence in our world: war and the military establishments that perpetuate it.
CLARION CALL is a meditative counter-recruitment to the adventurous vision of war actively sold by the military to every new generation of combat soldiers. By symbolizing phycological trauma and poetically transforming military iconography – particularly the practice of bayonet training which was designed to undo socialization and eradicate the reluctance of human beings to kill each other– LWT's ultimate mission is to be a part of the consciousness raising that one day breaks our cycle of violence, giving peace a fuller space to grow –in our hearts and in the world.


Citibank finalized its fusion with Banco Cuscatlán and Banco Uno in Costa Rica this week, and the two absorbed banks will now operate under the name Citi.
The merger creates one bank in Costa Rica with a net worth of more than $100 million, and total assets of more than $750 million, the daily La Nación reported.
In addition, Citi now has 500 ATM machines in Costa Rica, 67 branches and 80,000 clients.
Citibank acquired Grupo Financiero Uno in October 2006 and Cuscatlán the following December.
The banks were closed early in the week as the companies completed the merger.


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Theresa Flick Memorial Tulip Bench
Rick Flick designed the bench for Theresa because of her love of that flower. The artist took the original design and adapted it to the bench.Theresa fought Type 1 Diabetes from age 5. She had kidney complications in her 20's and after 2 kidney transplants, the first one in 1995 which was eventually successful until it started to fail in 2004, she received another transplant from Rick's sister, Judy Fritz, but it never did perform as it should have.
After several complications, heart, brain surgery etc. she passed away in 2008 at age 46. Through it all, anyone who knew her could tell you, she was a fighter, trying so hard to live to be mother to her young son, Ben.
Her fight to live was an inspiration to her family and friends...That's why the bench was created. To continue to inspire all who knew her.
After studying medicine for two years at Hiram College in Hiram, Ohio, Drumm decided to pursue a career in art. He transferred to Kent State University where he received a B.F.A. and an M.A.
In the late 1950s Drumm pioneered the use of cast aluminum as an artistic medium. In addition he has been a pioneer in the use of contemporary building materials, and techniques for the creation of Arts and crafts.
In 1960 Drumm opened his own studio, as a full time practicing Sculptor and designer/craftsman near the University of Akron in Akron, Ohio. In 1971, together with his wife, Lisa Drumm, he expanded the studio to incorporate a one-room gallery. Since then the enterprise has grown extensively and now embraces eight buildings, providing gallery facilities for over 500 artists and studio space for three resident artists.


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Home » News and Updates » CLASS OF NUKE 'EM HIGH" SOUNDTRACK FINALLY GETS OFFICIAL LP RELEASE - NOW AVAILABLE FOR PRE-ORDER!
CLASS OF NUKE 'EM HIGH" SOUNDTRACK FINALLY GETS OFFICIAL LP RELEASE - NOW AVAILABLE FOR PRE-ORDER!
"CLASS OF NUKE 'EM HIGH" SOUNDTRACK FINALLY GETS OFFICIAL LP RELEASE - NOW AVAILABLE FOR PRE-ORDER!
The OST of yesterday, now available for the youth of today!
We are honoured to have Skuzzles' sold out Class of Nuke em HIgh poster by Godmachine featured as the official artwork for Ship to Shore Phonograph Company's first Troma LP release. If you're a vinyl junkie like and movie buff like us, this is a very limited run that you definitely wont want to miss out on. Here's your chance to pick up a great collectible piece, officially licensed by Troma and released by Ship to Shore Phonograph Company. Below is the official low-down on the release.
New York, N.Y., July 22, 2014 - The Ship to Shore Phonograph Company announced today that the soundtrack to the Troma classic Class of Nuke 'Em High will finally get an official release, something fans have been waiting for since 1986! In conjunction with Troma, Ship To Shore have collated the glorious 80's anthems that made the soundtrack such a highly demanded item, and will release it to the public - on gloriously thick 180g vinyl! The LP is now available for pre-order at shiptoshore.storenvy.com and will street on November 11, 2014.
Featuring artwork originally created for Skuzzles' sold out Class of Nuke em High poster by Godmachine, the soundtrack will be limited to 1,000 copies. 700 copies will be on high quality 180 gram black vinyl, and 300 on special "Dewey's Meltdown" splattered vinyl. Each song has been meticulously remastered for optimum stereophonic listening pleasure, so fans can now enjoy them the way they the artists intended them.
Track listing is as follows:
Nuke 'Em High - Ethan & the Coup
Emotional Rufugee - David Behennah
Rock 'N' Roll Paradise - Stormbringer
Angel - GMT
Much Too Much - The Smithereens
Run For Your Life - Stratus (feat. Clive Burr of Iron Maiden)
We Are One - Ethan & the Coup (exclusive bonus track, never before released!)
Class of Nuke 'Em High Part 2 Theme
Inside the sleeve you can expect liner notes from director Lloyd Kaufman and theme song composer Ethan Hurt, along with never-before-seen production stills and behind-the-scenes production photos from the movie. And because the portable record player was never invented - at least successfully - each LP will also include an MP3 download of the full album, featuring exclusive track-by-track commentary by Troma President and Class of Nuke 'Em High co-director Lloyd Kaufman! For an exclusive sampler of the album, visit:
Sampler right here:
The album can only be ordered directly from the Ship To Shore Media webstore (shiptoshore.storenvy.com), and due to its limited run it is expected to sell out fast!
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Battle waves of hideous and unhygienic aliens, harvesting their blood to both fuel your ship and your weapons, and distract the hordes with decoys of your own ship, while seeking out their hives amongst the lava stricken landscape. Thanks to the contributors of OpenGameArt.org for helping us!
You must navigate your way through the cyber-punk world of tomorrow, using your array of upgradable weapons and various decoys to distract the onslaught of incoming enemy waves bent on keeping you from escaping with your life!


Fantastic 3 bedroom Detached Cottage offering modern living accommodation, stables, all weather arena and grazing, set in picturesque location on the outskirts of Moffat.
Accommodation: Hall, Kitchen, Liv Room, Cons, Bathroom, 3 Bedrooms. Grdns. 2 Stables. 3.5 acres.


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package nl.futureedge.simple.jmx.authenticator;

import javax.security.auth.callback.Callback;
import javax.security.auth.callback.LanguageCallback;
import javax.security.auth.callback.UnsupportedCallbackException;
import javax.security.auth.login.LoginException;
import org.junit.Test;

public class JMXCallbackHandlerTest {

    @Test(expected = LoginException.class)
    public void invalidCredentialsType() throws LoginException {
        new JMXCallbackHandler(new Object());
    }

    @Test(expected = LoginException.class)
    public void invalidCredentialsLength() throws LoginException {
        new JMXCallbackHandler(new String[]{"username"});
    }

    @Test(expected = UnsupportedCallbackException.class)
    public void testUnsupportedCallbackException() throws LoginException, UnsupportedCallbackException {
        final JMXCallbackHandler handler = new JMXCallbackHandler(new String[]{"username", "password"});
        final Callback callback = new LanguageCallback();
        handler.handle(new Callback[]{callback});
    }
}


Country living at it's best. Cleared undeveloped lot in small rural subdivision of 8 lots (7 still undeveloped ranging from 1.5 to 4 acres). Fronts public road. Perc test approved for mound system. Excise tax shall be responsibility of the buyer at settlement.
Listing courtesy of Champion Realty, Inc.


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Q: Netlify / React front end not connecting to Node.js / Express / MongoDB Atlas / Heroku backend but works in development/locally FIX: after following some advice I ditched the setupProxy and put the full API urls into the axios request. This threw a cors error so I imported CORS & added app.use(cors()) into my index.js & when I redeployed the app ran as intended
I am trying to deploy a MERN stack practise project for the first time. I am quite a new coder.
My project works perfectly fine in development/locally. My React app running on localhost:3000 connects to the Node/Express/MongoDB Atlas API that I deployed to Heroku & can make requests successfully.
However when I open the deployed Netlify app it fails to load any data & the Heroku logs show no activity which suggests it's not connecting to the backend at all.
Here are some bits of code that may be relevant:
-----------Backend---------------
environment.js (info in <> redacted)
export const dbURI = process.env.MONGODB_URI || 'mongodb+srv://<name>:<password>@festivalist.iyq41.mongodb.net/festivalist?retryWrites=true&w=majority'
export const port = process.env.PORT || 4000
export const secret = process.env.SECRET || '<secret>'

index.js
import express from 'express'
const app = express()
import mongoose from 'mongoose'
import router from './config/router.js'
import { port, dbURI } from './config/environment.js'

const startServer = async () => {
  try {
    await mongoose.connect(dbURI, { useNewUrlParser: true, useCreateIndex: true, useUnifiedTopology: true })
    console.log(' Database has connected successfully')

    app.use(express.json())

    app.use((req, _res, next) => {
      console.log(` Incoming request: ${req.method} - ${req.url}`)
      next()
    })

    app.use('/api', router)

    app.listen(port, () => console.log(` Express is up and running on port ${port}`))
  } catch (err) {
    console.log(' Something went wrong starting the app')
    console.log(err)
  }
}
startServer()

package.json
{
  "name": "sei-project-three",
  "version": "1.0.0",
  "main": "index.js",
  "dependencies": {
    "bcrypt": "^5.0.1",
    "dotenv": "^10.0.0",
    "express": "^4.17.1",
    "jsonwebtoken": "^8.5.1",
    "mongo": "^0.1.0",
    "mongoose": "^5.12.0",
    "nodemon": "^2.0.14"
  },
  "type": "module",
  "scripts": {
    "test": "echo \"Error: no test specified\" && exit 1",
    "seed": "node db/seeds.js",
    "dev": "nodemon",
    "start": "node index.js"
  },
  "devDependencies": {
    "eslint": "^7.22.0"
  },
  "engines": {
    "node": "16.8.0"
  }
}

-------------Front end --------------
setupProxy.js
const { createProxyMiddleware } = require('http-proxy-middleware')

module.exports = function (app) {
  app.use(createProxyMiddleware('/api', { target: 'https://festivalist-api.herokuapp.com', "changeOrigin": true }))
}

example request
const ArtistIndex = () => {
  const [artists, setArtists] = useState([])

  useEffect(() => {
    const getData = async () => {
      const { data } = await axios.get('/api/artists')
      setArtists(data)
    }
    console.log('artists2', artists)
    getData()
  }, [])

package.json
{
  "name": "client",
  "version": "0.1.0",
  "private": true,
  "dependencies": {
    "axios": "^0.21.1",
    "http-proxy-middleware": "^1.0.5",
    "mapbox-gl": "^2.2.0",
    "react": "^17.0.2",
    "react-dom": "^17.0.2",
    "react-map-gl": "^5.2.5",
    "react-mapbox-gl": "^5.1.1",
    "react-router-dom": "^5.2.0",
    "react-scripts": "4.0.3",
    "sass": "^1.42.1",
    "semantic-ui-css": "^2.4.1",
    "semantic-ui-react": "^2.0.3"
  },
  "scripts": {
    "start": "react-scripts start",
    "build": "react-scripts build",
    "test": "react-scripts test",
    "eject": "react-scripts eject"
  },
  "eslintConfig": {
    "extends": "react-app"
  },
  "browserslist": {
    "production": [
      ">0.2%",
      "not dead",
      "not op_mini all"
    ],
    "development": [
      "last 1 chrome version",
      "last 1 firefox version",
      "last 1 safari version"
    ]
  },
  "devDependencies": {
    "@typescript-eslint/eslint-plugin": "^4.25.0",
    "@typescript-eslint/parser": "^4.25.0",
    "babel-eslint": "^10.1.0",
    "eslint": "^7.27.0",
    "eslint-config-react-app": "^6.0.0",
    "eslint-plugin-flowtype": "^5.7.2",
    "eslint-plugin-import": "^2.23.3",
    "eslint-plugin-jsx-a11y": "^6.4.1",
    "eslint-plugin-react": "^7.23.2",
    "eslint-plugin-react-hooks": "^4.2.0"
  }
}

Some notes:

*

*I have whitelisted all IP addresses in MongoDB Atlas 0.0.0.0/0

*I'm unsure why but I have to put '/api/' on the end of the heroku api url to get the data ie: https://festivalist-api.herokuapp.com/api/festivals

*I added Config Vars in Heroku but I think that stopped my app from working locally so I deleted them. Also not fully sure I understand what they do.

I have been trying to deploy this for days now so any advice would be a help or any troubleshooting tips since I am new to coding! Thanks

A: You have to put '/api' in at the end of heroku API because that's what you've used in your backend index.js app.use('/api', router)
The problem seems like something to do with the middle-wear setupProxy.js since you can ping the API already. One workaround is to just update your requests to use the full URI. i.e
const ArtistIndex = () => {
  const [artists, setArtists] = useState([])

  useEffect(() => {
    const getData = async () => {
      const { data } = await axios.get('https://festivalist-api.herokuapp.com/api/artists')
      setArtists(data)
    }
    console.log('artists2', artists)
    getData()
  }, [])

redpajama_set_name: RedPajamaStackExchange


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Home > Shows > Electromagnetic Pulse Attack
Electromagnetic Pulse Attack
Date Friday - November 27, 2009
Guests William R. Forstchen
Filling in for George, Art Bell spoke with Prof. William Forstchen for the entire program about how an electromagnetic pulse (EMP) attack by a rogue nation could disable America's power grid and communications infrastructure, and lead to an inconceivably high death toll.
Forstchen provided details on Starfish Prime, a high-altitude nuclear test conducted by the U.S. in 1962, which increased our awareness of the serious repercussions of EMP. The detonation took place high above the Pacific Ocean yet caused significant electrical damage several hundred miles away in Hawaii, he said.
Major solar flares can also produce EMP, Forstchen added, noting the Carrington Event of 1859, the most powerful solar storm in recorded history. If such a storm hit our planet today, over 80% of the electrical generating systems in the Eastern U.S. would still be offline four years later, he estimated.
Forstchen pointed out that North Korea or Iran could easily place an EMP-calibrated weapon within range of America and blow out the entire U.S. power grid. A 2004 Congressional Study projected a stunning 90% fatality rate from such an attack, he remarked, explaining that it would cause an almost immediate shortage of potable water, food and medical supplies, and eventually lead to a economic and societal collapse.
"We can stop this before it happens," Forstchen said, agreeing with Art's assessment that America should preemptively strike any country preparing to launch an EMP attack against it. Forstchen also proposed the U.S. harden its infrastructure and begin stockpiling replacement parts to rebuild it.
onesecondafter.com
Sea Lions Fight Terrorism
The U.S. Navy has begun using specially trained sea lions in their post-9/11 fight against terrorism. A Californian sea lion named Gremlin recently demonstrated his underwater minesweeping skills by attaching a line to a test object on the sea floor (pictured). The super-trained animal can also immobilize suspicious divers with leg cuffs, as well as provide live video from under the surface. More at Mail Online.
Bumper music from Friday November 27, 2009
Wicked Game
Boom Boom Ba
Ride My Seesaw
Year of the Cat
Crunchy Granola Suite
Some Velvet Morning
Nancy Sinatra & Lee Hazlewood
It Don't Come Easy
Midnight in the Desert
Numerology & Climate-Gate
Plot to Islamize America