Mild atherosclerosis usually doesn't have any symptoms. Atherosclerosis symptoms usually don't happen until an artery is so narrowed or clogged that it can't supply enough blood to organs and tissues. Sometimes a blood clot completely blocks blood flow. The clot may break apart and can trigger a heart attack or stroke. Symptoms of moderate to severe atherosclerosis depend on which arteries are affected. For example: 
If you have atherosclerosis in your heart arteries, you may have chest pain or pressure (angina).
If you have atherosclerosis in the arteries leading to your brain, you may have sudden numbness or weakness in your arms or legs, difficulty speaking or slurred speech, temporary loss of vision in one eye, or drooping muscles in your face. These signal a transient ischemic attack (TIA). Untreated, a TIA can lead to a stroke.
If you have atherosclerosis in the arteries in your arms and legs, you may have symptoms of peripheral artery disease, such as leg pain when walking (claudication) or decreased blood pressure in an affected limb.
If you have atherosclerosis in the arteries leading to your kidneys, you may develop high blood pressure or kidney failure.
