Signs and symptoms of systemic mastocytosis depend on the part of the body affected by excessive mast cells. Too many mast cells can build up in the skin, liver, spleen, bone marrow or intestines. Less commonly, other organs such as the brain, heart or lungs also may be affected. Signs and symptoms of systemic mastocytosis may include: 
Flushing, itching or hives
Abdominal pain, diarrhea, nausea or vomiting
Anemia or bleeding disorders
Bone and muscle pain
Enlarged liver, spleen or lymph nodes
Depression, mood changes or problems concentrating
 The mast cells are triggered to produce substances that cause inflammation and symptoms. People have different triggers, but the most common ones include: 
Alcohol
Skin irritation
Spicy foods
Exercise
Insect stings
Certain medications
 When to see a doctor When to see a doctor  Talk to your doctor if you have problems with flushing or hives, or if you have concerns about the signs or symptoms listed above. Causes Most cases of systemic mastocytosis are caused by a random change (mutation) in the KIT gene. Typically this flaw in the KIT gene is not inherited. Too many mast cells are produced and build up in tissues and body organs, releasing substances such as histamine, leukotrienes and cytokines that cause inflammation and symptoms. Complications Complications of systemic mastocytosis can include: 
Anaphylactic reaction. This severe allergic reaction includes signs and symptoms such as rapid heartbeat, fainting, loss of consciousness and shock. If you have a severe allergic reaction, you may need an injection of epinephrine.
Blood disorders. These can include anemia and poor blood clotting.
Peptic ulcer disease. Chronic stomach irritation can lead to ulcers and bleeding in your digestive tract.
Reduced bone density. Because systemic mastocytosis can affect your bones and bone marrow, you may be at risk of bone problems, such as osteoporosis.
Organ failure. A buildup of mast cells in body organs can cause inflammation and damage to the organ.
  

  




 


 
 By Mayo Clinic Staff By Mayo Clinic Staff 
Systemic mastocytosis care at Mayo Clinic
