The signs and symptoms of hypopituitarism usually develop gradually and get worse over time. They are sometimes subtle and may be overlooked for months or even years. But for some people, signs and symptoms develop suddenly. Signs and symptoms of hypopituitarism vary from person to person, depending on which pituitary hormones are affected and to what degree. In people who have more than one pituitary hormone deficiency, the second deficiency may increase or, in some cases, hide the symptoms of the first deficiency. Growth hormone (GH) deficiency In children, GH deficiency may cause growth problems and short stature. Most adults who have GH deficiency don't have any symptoms, but for some adults it can cause: GH GH 
Fatigue
Muscle weakness
Changes in body fat composition
Lack of ambition
Social isolation
 Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) deficiency Deficiency of these hormones, called gonadotropins, affect the reproductive system. In women, the deficiency decreases egg and estrogen production from the ovaries. In men, the deficiency decreases sperm and testosterone production from the testicles. Women and men may experience a lower sex drive, infertility or fatigue. In children and adolescents, delayed puberty is usually the only symptom. Women may also have symptoms such as: 
Hot flashes
Irregular or no periods
Loss of pubic hair
An inability to produce milk for breast-feeding
 Men may also have symptoms such as: 
Erectile dysfunction
Decreased facial or body hair
Mood changes
 Thyroid-stimulating hormone (TSH) deficiency This hormone controls the thyroid gland. A TSH deficiency leads to low levels of thyroid hormones (hypothyroidism). This causes symptoms such as: TSH 
Fatigue
Weight gain
Dry skin
Constipation
Sensitivity to cold or difficulty staying warm
 Adrenocorticotropic hormone (ACTH) deficiency This hormone helps your adrenal glands work properly, and helps your body react to stress. Symptoms of ACTH deficiency include: ACTH 
Severe fatigue
Low blood pressure, which may lead to fainting
Frequent and prolonged infections
Nausea, vomiting or abdominal pain
Confusion
 Anti-diuretic hormone (ADH) deficiency This hormone, which is also called vasopressin, helps your body balance its fluid levels. An ADH deficiency can cause a disorder called diabetes insipidus, which can cause: ADH 
Excessive urination
Extreme thirst
Electrolyte imbalances
 Prolactin deficiency Prolactin is the hormone that tells the body when to start making breast milk. Low levels of prolactin can cause women to have problems making milk for breast-feeding.