Babies with XLA generally appear healthy for the first few months because they're protected by the antibodies they got from their mothers before birth. When these antibodies clear from their systems, the babies begin to develop often severe, recurrent bacterial infections — such as of the ears, lungs, sinuses and skin — that can be life-threating. XLA Male infants born with XLA have: XLA 
Very small tonsils
Small or no lymph nodes
 Causes 




	    X-linked inheritance pattern with carrier mother
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X-linked inheritance pattern with carrier mother


X-linked inheritance pattern with carrier mother
Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier.




 


	    X-linked inheritance pattern with carrier mother
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	    X-linked inheritance pattern with carrier mother
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X-linked inheritance pattern with carrier mother


X-linked inheritance pattern with carrier mother
Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier.



 




Close



X-linked inheritance pattern with carrier mother


X-linked inheritance pattern with carrier mother
Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier.


 



Close



X-linked inheritance pattern with carrier mother


X-linked inheritance pattern with carrier mother
Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier.

 

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 Close X-linked inheritance pattern with carrier mother  
X-linked inheritance pattern with carrier mother
Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier.
 X-linked inheritance pattern with carrier mother Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier. Women can pass down X-linked recessive disorders such as X-linked agammaglobulinemia. A woman who is a carrier of an X-linked recessive disorder has a 25% chance of having an unaffected son, a 25% chance of having an affected son, a 25% chance of having an unaffected daughter and a 25% chance of having a daughter who also is a carrier. X-linked agammaglobulinemia is caused by a genetic mutation. People with the condition can't produce antibodies that fight infection. About 40% of people with the condition have a family member who has it. Complications People with XLA can live relatively normal lives and should be encouraged to participate in regular activities for their ages. However, recurrent infections related to XLA will likely require careful attention and aggressive treatment. They can cause organ damage and be life-threatening. XLA XLA Possible complications include: 
Chronic lung disease
Increased risk of certain cancers
Infectious arthritis
Increased risk of central nervous system infections from live vaccines
  

  




 


 
 By Mayo Clinic Staff By Mayo Clinic Staff 
X-linked agammaglobulinemia care at Mayo Clinic
