More than half the people with primary biliary cholangitis do not have any noticeable symptoms when diagnosed. The disease may be diagnosed when blood tests are done for other reasons, such as routine testing. Symptoms eventually develop over the next 5 to 20 years. Those who do have symptoms at diagnosis typically have poorer outcomes. Common early symptoms include: 
Fatigue
Itchy skin
 Later signs and symptoms may include: 
Dry eyes and mouth
Pain in the upper right abdomen
Swelling of the spleen (splenomegaly)
Bone, muscle or joint (musculoskeletal) pain
Swollen feet and ankles (edema)
Buildup of fluid in the abdomen due to liver failure (ascites)
Fatty deposits (xanthomas) on the skin around the eyes, eyelids or in the creases of the palms, soles, elbows or knees
Yellowing of the skin and eyes (jaundice)
Darkening of the skin that's not related to sun exposure (hyperpigmentation)
Weak and brittle bones (osteoporosis), which can lead to fractures
High cholesterol
Diarrhea, which may include greasy stools (steatorrhea)
Underactive thyroid (hypothyroidism)
Weight loss
