One of the most common signs of primary immunodeficiency is having infections that are more frequent, longer lasting or harder to treat than are the infections of someone with a typical immune system. You may also get infections that a person with a healthy immune system likely wouldn't get (opportunistic infections). Signs and symptoms differ depending on the type of primary immunodeficiency disorder, and they vary from person to person. Signs and symptoms of primary immunodeficiency can include: 
Frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections
Inflammation and infection of internal organs
Blood disorders, such as low platelet count or anemia
Digestive problems, such as cramping, loss of appetite, nausea and diarrhea
Delayed growth and development
Autoimmune disorders, such as lupus, rheumatoid arthritis or type 1 diabetes
