Mitral valve regurgitation is often mild and progresses slowly. Some people with mitral valve regurgitation might not have symptoms for many years. But sometimes, mitral valve regurgitation develops quickly. This condition, called acute mitral valve regurgitation, causes sudden signs and symptoms. Fatigue is a common but nonspecific symptom of mitral valve regurgitation. Other signs and symptoms of mitral valve regurgitation include: 
Sound of blood flow across the valve (heart murmur)
Irregular heartbeat (arrhythmia)
Shortness of breath (dyspnea), especially when lying down
Sensation of a rapid, pounding or fluttering heartbeat (palpitations)
Swollen feet or ankles (edema)
