Small vessel disease signs and symptoms include: 
Chest pain, squeezing or discomfort (angina), which may get worse with activity or emotional stress
Discomfort in the left arm, jaw, neck, back or abdomen along with chest pain
Shortness of breath
Tiredness and lack of energy
 If you've been treated for coronary artery disease with angioplasty and stents and your signs and symptoms haven't gone away, you might also have small vessel disease.