Signs and symptoms of adrenal cancer include: 
Weight gain
Muscle weakness
Pink or purple stretch marks on the skin
Hormone changes in women that might cause excess facial hair, hair loss on the head and irregular periods
Hormone changes in men that might cause enlarged breast tissue and shrinking testicles
Nausea
Vomiting
Abdominal bloating
Back pain
Fever
Loss of appetite
Loss of weight without trying
 Causes It's not clear what causes adrenal cancer. Adrenal cancer forms when something creates changes (mutations) in the DNA of an adrenal gland cell. A cell's DNA contains the instructions that tell a cell what to do. The mutations can tell the cell to multiply uncontrollably and to continue living when healthy cells would die. When this happens, the abnormal cells accumulate and form a tumor. The tumor cells can break away and spread (metastasize) to other parts of the body. Risk factors Adrenal cancer happens more often in people with inherited syndromes that increase the risk of certain cancers. These inherited syndromes include: 
Beckwith-Wiedemann syndrome
Carney complex
Li-Fraumeni syndrome
Lynch syndrome
Multiple endocrine neoplasia, type 1 (MEN 1)
 By Mayo Clinic Staff By Mayo Clinic Staff 
Adrenal cancer care at Mayo Clinic
