Signs and symptoms of mesothelioma vary depending on where the cancer occurs. Pleural mesothelioma, which affects the tissue that surrounds the lungs, causes signs and symptoms that may include: Pleural mesothelioma 
Chest pain
Painful coughing
Shortness of breath
Unusual lumps of tissue under the skin on your chest
Unexplained weight loss
 Peritoneal mesothelioma, which occurs in tissue in the abdomen, causes signs and symptoms that may include: Peritoneal mesothelioma 
Abdominal pain
Abdominal swelling
Nausea
Unexplained weight loss
 Other forms of mesothelioma Signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare. Pericardial mesothelioma, which affects tissue that surrounds the heart, can cause signs and symptoms such as breathing difficulty and chest pains. Mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.