 Signs and symptoms of familial Mediterranean fever usually begin during childhood. They occur in bouts called attacks that last 1-3 days. Arthritic attacks may last for weeks or months. Signs and symptoms of FMF attacks vary, but can include: FMF 
Fever
Abdominal pain
Chest pain, which can make it hard to breathe deeply
Painful, swollen joints, usually in the knees, ankles and hips
A red rash on your legs, especially below your knees
Muscle aches
A swollen, tender scrotum
 The attacks generally resolve spontaneously after a few days. Between attacks, you'll likely feel back to your typical health. Symptom-free periods may be as short as a few days or as long as several years. In some people, the first sign of FMF is amyloidosis. With amyloidosis, the protein amyloid A, which is not typically found in the body, builds up in organs ⸺ especially the kidneys ⸺ causing inflammation and interfering with their function.