The signs and symptoms of Cushing syndrome can vary depending on the levels of excess cortisol. Common signs and symptoms of Cushing syndrome 
Weight gain and fatty tissue deposits, particularly around the midsection and upper back, in the face (moon face), and between the shoulders (buffalo hump)
Pink or purple stretch marks (striae) on the skin of the abdomen, thighs, breasts and arms
Thinning, fragile skin that bruises easily
Slow healing of cuts, insect bites and infections
Acne
 Signs and symptoms women with Cushing syndrome may experience 
Thicker or more visible body and facial hair (hirsutism)
Irregular or absent menstrual periods
 Signs and symptoms men with Cushing syndrome may experience 
Decreased sex drive
Decreased fertility
Erectile dysfunction
 Other possible signs and symptoms of Cushing syndrome 
Severe fatigue
Muscle weakness
Depression, anxiety and irritability
Loss of emotional control
Cognitive difficulties
New or worsened high blood pressure
Headache
Infections
Skin darkening
Bone loss, leading to fractures over time
In children, impaired growth
