Signs and symptoms of primary ovarian insufficiency are similar to those of menopause or estrogen deficiency. They include: 
Irregular or skipped periods, which might be present for years or develop after a pregnancy or after stopping birth control pills
Difficulty getting pregnant
Hot flashes
Night sweats
Vaginal dryness
Dry eyes
Irritability or difficulty concentrating
Decreased sexual desire
 When to see a health care provider If you've missed your period for three months or more, see your health care provider to determine the cause. You can miss your period for a number of reasons — including pregnancy, stress, or a change in diet or exercise habits — but it's best to get evaluated whenever your menstrual cycle changes. Even if you don't mind not having periods, it's advisable to see your provider to find out what's causing the change. Low estrogen levels can lead to bone loss and an increased risk of heart disease.