In Crohn's disease, any part of your small or large intestine can be involved. It may involve multiple segments, or it may be continuous. In some people, the disease is only in the colon, which is part of the large intestine. Signs and symptoms of Crohn's disease can range from mild to severe. They usually develop gradually, but sometimes will come on suddenly, without warning. You may also have periods of time when you have no signs or symptoms (remission). When the disease is active, symptoms typically include: 
Diarrhea
Fever
Fatigue
Abdominal pain and cramping
Blood in your stool
Mouth sores
Reduced appetite and weight loss
Pain or drainage near or around the anus due to inflammation from a tunnel into the skin (fistula)
 Other signs and symptoms People with severe Crohn's disease may also experience symptoms outside of the intestinal tract, including: 
Inflammation of skin, eyes and joints
Inflammation of the liver or bile ducts
Kidney stones
Iron deficiency (anemia)
Delayed growth or sexual development, in children
