Signs and symptoms of primary lateral sclerosis usually take years to progress and generally begin in the legs. Rarely, PLS begins in your tongue or hands and then progresses down your spinal cord to your legs. However, the disease has highly variable effects from person to person. Signs and symptoms may include: PLS 
Stiffness, weakness and muscle spasms (spasticity) in your legs, rarely starting in one leg, and eventually progressing to your arms, hands, tongue and jaw
Slowed movement
Tripping, clumsiness and difficulty with balance
Hand clumsiness
Hoarseness, as well as slowed, slurred speech and drooling
Difficulties with chewing and swallowing
Sometimes, frequent, rapid and intense shifts in emotions (mood lability)
Rarely, breathing problems and bladder problems late in the disease
