A common sign of acromegaly is enlarged hands and feet. For example, you may notice that you aren't able to put on rings that used to fit, and that your shoe size has progressively increased. Acromegaly may also cause gradual changes in your face's shape, such as a protruding lower jaw and brow bone, an enlarged nose, thickened lips, and wider spacing between your teeth. Because acromegaly tends to progress slowly, early signs may not be obvious for years. Sometimes, people notice the physical changes only by comparing old photos with newer ones. Overall, acromegaly signs and symptoms tend to vary from one person to another, and may include any of the following: 
Enlarged hands and feet
Enlarged facial features, including the facial bones, lips, nose and tongue
Coarse, oily, thickened skin
Excessive sweating and body odor
Small outgrowths of skin tissue (skin tags)
Fatigue and joint or muscle weakness
Pain and limited joint mobility
A deepened, husky voice due to enlarged vocal cords and sinuses
Severe snoring due to obstruction of the upper airway
Vision problems
Headaches, which may be persistent or severe
Menstrual cycle irregularities in women
Erectile dysfunction in men
Loss of interest in sex
