Signs and symptoms of corticobasal degeneration (corticobasal syndrome) include: 
Difficulty moving on one or both sides of the body, which gets worse over time
Poor coordination
Trouble with balance
Stiffness
Abnormal postures of the hands or feet, such as a hand forming a clenched fist
Muscle jerks
Difficulty swallowing
Abnormal eye movements
Trouble with thinking and language skills
Speech problems, such as slow and halting speech
Difficulty swallowing
 Corticobasal degeneration progresses over six to eight years. Eventually, people with corticobasal degeneration lose the ability to walk.