The mildest forms of histoplasmosis cause no signs or symptoms. But severe infections can be life-threatening. When signs and symptoms occur, they usually appear 3 to 17 days after exposure and can include: 
Fever
Chills
Headache
Muscle aches
Dry cough
Chest pain
Tiredness
 Some people with histoplasmosis also get joint pain and a rash. People who have a lung disease, such as emphysema, can develop chronic histoplasmosis. Signs of chronic histoplasmosis can include weight loss and a bloody cough. Chronic histoplasmosis symptoms sometimes mimic those of tuberculosis. Severe histoplasmosis The most severe variety of histoplasmosis occurs mainly in infants and in people with weakened immune systems. Called disseminated histoplasmosis, it can affect nearly any part of your body, including your mouth, liver, central nervous system, skin and adrenal glands. If untreated, disseminated histoplasmosis is usually fatal.