Sr. Scientist, Quantitative Translational Sciences
$117K-$206K (Glassdoor est.)
Job Description


Millennium Pharmaceuticals is seeking a Sr. Scientist, Quantitative Translational Sciences in Cambridge, MA with the following requirements: Master’s degree in Pharmaceutical Sciences or a related biomedical engineering field and 10 years related experience. Prior experience must include at least 6 years with each of the following: design and develop PK and PK/PD models of multilayer mechanistic drug exposure to drug response relationship in CNS therapies including circulating pharmacokinetics, brain distribution, target engagement and downstream pathway modulation, and translate the models from experimental animals to humans using NONMEM, Phoenix and Berkeley Madonna; design, plan and execute experiments to obtain the biological input data to design and implement PBPK and PK/PD modeling for absorption, tissue distribution and elimination with addressing inter-individual variability through non-linear mixed effect modeling using NONMEM, Berkeley Madonna and Simcyp; build PBPK models to quantitatively predict the risk of metabolism- and/or transporter-mediated drug-drug interactions in humans through the extrapolation of in vitro experimental findings to in vivo using Simcyp. Apply on-line at www.takedajobs.com

Locations


Boston, MA

Worker Type


Employee

Worker Sub-Type


Regular

Time Type


Full time
Takeda Pharmaceuticals
3.7
Takeda Pharmaceuticals
