Pricipal Scientist Molecular and cellular biologist
$52K-$101K (Glassdoor est.)
Job Description


OBJECTIVE:
Help us make safer drugs |The next generation of life changing medicines include gene therapies, oligonucleotides and cell therapies all honed to treat previously untreatable diseases. Help us shape this next generation of life-saving medicines by improving the design of next-generation therapeutics based on proactive detection & de-risking of dose limiting toxicities related to liver.
Deliver decision-making data |Design & deliver of state-of-the-art in vitro assays to detect & de-risk toxicity for medicines in discovery & development. Help shape the evolution of cell & gene therapies to deliver safer & more effective medicines for patients with rare diseases.
Lead toxicological investigations to detect & de-risk toxicities in drug discovery and development using in vitro and in vivo data.
Use cutting edge cell culture and organ-on-a-chip technologies to help make the next generation of gene and cell therapies.
Probe molecular and cellular mechanisms of toxicity to determine drivers of liver, lung and cardiovascular toxicities and guide drug projects to make safer medicines using your experience, in-house, and literature data.
Drive the development of safer gene and cell therapiesusing in vitro and in vivo data from a matrixed project team.
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
PhD in biology, pharmacology, toxicology or a related discipline with PostDoc experience.
Experience with conventional and advanced cell culture approaches with cell lines, primary cells, and iPSC cells. Experience with 3D cell-culture highly desirable.
Experience in assays related to liver safety biomarkers, transporters, and P450 enzymes is desired.
Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for de-risking drug candidates.
Experience with organ systems in addition to liver such as cardiovascular, GI, and immune systems is highly desired
Strong interpersonal and organizational skills
Excellent oral and written communication skills
LICENSES/CERTIFICATIONS:
DABT certification a plus, but not necessary
Locations


Boston, MA

Worker Type


Employee

Worker Sub-Type


Regular

Time Type


Full time
Takeda Pharmaceuticals
3.7
Takeda Pharmaceuticals
