Scientist, Molecular/Cellular Biologist
$49K-$97K (Glassdoor est.)
[1]Scientist, Molecular/Cellular Biologist

About Audentes Therapeutics

Audentes Therapeutics is a leading AAV-based genetic medicines company focused on developing and commercializing innovative products for serious rare neuromuscular diseases. We are leveraging our AAV gene therapy technology platform and proprietary manufacturing expertise to develop programs across three modalities: gene replacement, vectorized exon skipping, and vectorized RNA knockdown. Our product candidates are showing promising therapeutic profiles in clinical and preclinical studies across a range of neuromuscular diseases. Audentes is a focused, experienced, and passionate team driven to improve the lives of patients.

Audentes leverages strong, global relationships with the patient, research, and medical communities, and we take pride in carefully selecting our colleagues. Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us on our journey.

The Role

Reporting to the Director, Discovery Biology, Audentes Therapeutics is seeking an innovative and talented scientist with expertise in gene therapy and viral vector to join the Discovery Biology group located in South San Francisco. This position will be a member of a team responsible to characterize and test candidate AAV gene therapy vectors to address indications within the Company's gene therapy pipeline. Additional responsibilities include, providing scientific results that support the generation of publications, patents, or regulatory submissions.

Responsibilities
Plan and execute in vitro experiments to evaluate and characterize candidate AAV gene therapy vectors in primary and/or mammalian muscle cell lines.
Analyze cells by flow cytometry, qPCR, RT-PCR, ddPCR.
Perform and interpret cell-based functional assays.
Collect and evaluate data; prepare reports, summaries and presentations; maintain and update laboratory notebook and the laboratory information management system, as appropriate, according to company policy
Keep up to date with the literature in the field.
Additional duties as assigned.
Required Qualifications
PhD in Molecular Biology, Life Sciences or related field with 2+ years of related experience.
Broad laboratory experience and skills in cell biology techniques and cell-based assays (including transfection, viral transduction, flow cytometry, cell-based assay development, etc)
Proven experience in molecular biology techniques including genomic DNA and RNA isolation, qPCR, ddPCR, RT-PCR, etc.
Demonstrated knowledge and working experience in AAV viral gene therapy and/or pre-clinical research and development.
Designing and performing experiments with minimal supervision, analyze results and interpret the data with strong scientific rigor, present at team meetings and contribute to publication.
Critical thinking, innovative and adept at troubleshooting
Ability to work in teams and collaborate closely with researchers across Audentes and external collaborators.
Demonstrated innovative design and execution of research projects through literature review, and scientific teamwork
Models our Core Values: Be Bold, Care Deeply, #GetStuffDone - is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted
Preferred Qualifications
Experience in in vitro models for neuromuscular diseases preferred
Industry experience preferred
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

[1][1] Title commensurate with experience

(ref. R-201903-JM)
Audentes Therapeutics
2.9
Audentes Therapeutics
