Principal Scientist - Immunologist
$98K-$182K (Glassdoor est.)
Job Description


OBJECTIVE:
Make gene therapies and biologics Safer |The next generation of gene therapies come with uncharted safety risks. Help direct pharmaceutical drug project teams with expert advice on how to design safer, more effective cell, protein and small molecule immunotherapies.
Help develop Immunotoxicity Strategy |Deliver critical data and ideas to guide projects through discovery and development. The successful candidate will develop global strategy for designing & delivering of state-of-the-art immunoassays to detect & de-risk immune-mediated toxicities for candidate drug molecules.
Immunology Problem Solving |Unwanted immune activation and inhibition can derail even the most promising drug projects. Lead problem-solving teams to help save these projects & make safer drugs for patients.
Develop and deliver novel immune assays, including traditional immune cell culture as well as advanced organ-on-a-chip technologies
Use genomics, molecular & cellular biology to investigate mechanisms of drug-induced toxicity
Help guide the development of gene therapies, oligonucleotide therapies, and therapeutic viral vectors.
Steer drug discovery teams to make safer medicines using experience, in-house, and literature data.
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
PhD in Immunology or related field, or Masters with 3+ years of industry experience.
Experience with advanced cell culture approaches with cell lines, primary cells, and iPSC cells.
Cell and molecular biology skills including flow cytometry, application of knock-out, knock-down technology, gene expression analysis, and biomarker assay development and validation
Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
Broad scientific knowledge including immunology, pharmacology, toxicology, pathology, physiology and biochemistry.
Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for derisking drug candidates.
Skills in pathway analysis, network pharmacology
Strong interpersonal and organizational skills
Excellent oral and written communication skills
Locations


Boston, MA

Worker Type


Employee

Worker Sub-Type


Regular

Time Type


Full time
Takeda Pharmaceuticals
3.7
Takeda Pharmaceuticals
