Scientist - CVRM Metabolism - in vivo pharmacology
$61K-$123K (Glassdoor est.)
AstraZeneca has an opportunity for a Scientist position within the Bioscience Metabolism group of the Cardiovascular, Renal and Metabolism department (CVRM) in Gaithersburg, MD.

The successful candidate should have hands-on in vivo pharmacology experience, particularly in rodent models of diabetes, obesity and NASH.

Expertise in working with anti-sense oligonucleotides would be a plus, and ex vivo lab techniques including tissue gene expression, ELISAs, western blot analysis etc. is required.

The successful candidate will be greatly involved with experimental work, including the

design, execution and interpretation of preclinical experimental data.

Additionally, the candidate will present results to CVRM group and project team meetings.

The ability to work well in a team environment, and to interact with departments outside of CVRM is essential for this position.

Requirements:

Education: Degree in a biological science field MS and 3 plus years of relevant experience or BS and 5 plus years of relevant experience.
Highly proficient in working with rodent models of NASH, diabetes and obesity hands on expertise in animal handling, dosing (SC, IV, PO and IM), and necropsy tissue collections (essential)
Administration of CVRM therapeutic modalities, including ASOs, to CVRM rodent models (essential)
Independently execute ex vivo analysis of blood/tissue samples including qPCR gene expression, Western blots, and ELISAs (essential)
Take part in all experimental work, including the design, analysis and interpretation of data from these experiments (essential)
Prepare and present scientific data to CVRM in vivo group meetings (essential) and project team meetings (desirable)
Work in a cross-functional project team with responsibility of making decisions and recommendations for program in vivo pharmacology plans (essential)
Develop an understanding of the scientific basis of the CVRM project pipeline, to be able to successfully execute experiments needed to meet the requirements of the projects involved with (essential)
Contribute to CVRM animal model work and/or development including areas of NASH, obesity, dyslipidemia, CV and diabetic kidney disease (essential)
Execution of metabolism in vivo assays including GTTs, ITTs, and measurement food intake (desirable)
Experience in surgical procedures desirable
Experience in pharmaceutical industry desirable
AstraZeneca
3.9
AstraZeneca
