Scientist I/II, Biology
$67K-$137K (Glassdoor est.)
Scientist I/II, Biology

Cambridge, MA

BIO20-901

At Blueprint Medicines, we are creating a blueprint for the future of healthcare. We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease. We do this by leveraging our one-of-a-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally. This prolific scientific platform has enabled Blueprint Medicines to build a pipeline of novel therapies that span three distinct areas of medicine; genomically defined cancers, rare diseases and cancer immunotherapy.

[Objective of position]

Responsibilities:

Blueprint Medicines is seeking a highly motivated, experienced and collaborative laboratory scientist to work within a cross-functional team to expand our small-molecule drug discovery platform. The individual should possess strong core competency in cell and molecular biology and protein degradation, as well as the development and execution of cell-based assays for compound evaluation employing a variety of technology platforms. This hands-on candidate is expected to independently design, carry out and interpret experiments, and present data in various forums. The successful candidate will also contribute to the design and execution of key experiments to investigate cellular and molecular mechanisms as consequence of target inhibition and degradation. This position offers the opportunity to impact a growing portfolio of targeted therapy programs in a fast-paced and innovative research environment.

Qualifications and capabilities:
PhD in cell biology, cancer biology, chemical biology or related discipline with a strong publication record and 2-3 years of relevant laboratory experience in an industry
Experience in protein degradation is a must
Experience with proteomics and CeTSA or other target engagement technologies is a plus
Proficient in mammalian cell culture and cell line development; familiar with automation systems/platforms is a plus
Independently design, optimize, troubleshoot, validate, and implement cell-based assays
Employ a breadth of cell and molecular biology techniques, to investigate MOA/biology to inform project team, translational medicine, clinical strategies
Responsible for data processing, interpreting and reporting to cross functional team members
Strong oral and written communication and excellent data management (e.g. ELN, Core, LIMS) skills
Strong interpersonal and collaboration skills
A team player, who listens effectively, invites response and discussion
All applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability, sexual orientation, gender or protected veteran status.

WHO WE ARE:

Blueprint Medicines mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We dont think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

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Blueprint Medicines
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Blueprint Medicines
