As an IACUC member, I need to understand the OLAW guidelines for animal transfers, specifically regarding the requirement for a new IACUC review for animals transferred between PHS-Assured institutions. Additionally, I need to clarify the acceptable methods of euthanasia for non-rodent fetuses and neonates, including any specific considerations for the use of carbon dioxide. Can you provide this information based on OLAW's guidance?
Navigate to 'https://olaw.nih.gov'. Click on 'Resources' in the main navigation. Click on 'FAQs' within the expanded 'Resources' menu. Locate and click on the FAQ titled 'Animal Transfers' or 'Do animals transferred between PHS-Assured institutions require a new IACUC review?'. Extract the information regarding IACUC review requirements for animals transferred between PHS-Assured institutions. Navigate back to the OLAW homepage. Use the search bar on the homepage to search for 'euthanasia'. From the search results, identify and click on the most relevant document or FAQ related to euthanasia guidelines, specifically looking for information on non-rodent fetuses and neonates. Extract information on acceptable methods of euthanasia for non-rodent fetuses and neonates, and any specific considerations for carbon dioxide use. Synthesize all gathered information to answer the task.
The agent successfully navigates to the 'Animal Transfers' FAQ page. The agent accurately states that animals transferred between PHS-Assured institutions generally do not require a new IACUC review at the receiving institution if the protocol at the sending institution was previously reviewed and approved by an IACUC operating under a PHS Assurance. The agent successfully uses the search bar to find euthanasia guidance. The agent accurately identifies acceptable methods of euthanasia for non-rodent fetuses and neonates (e.g., overdose of anesthetic, physical methods). The agent accurately states specific considerations for carbon dioxide use for non-rodent neonates, such as the need for an extended exposure time and/or confirmation of death by a secondary method due to their resistance to hypoxia.