Find the 'BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)' funding opportunity. Identify its primary purpose, the specific types of clinical studies it supports, and the original funding opportunity number it reissued. Provide these three pieces of information.
Navigate to the 'Notices of Funding Opportunities' page on braininitiative.nih.gov. Locate and click on the link for 'BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)' from the list of open opportunities. On the detailed funding opportunity page, locate and extract the 'Funding Opportunity Purpose' section to identify the primary goal. Within the 'Funding Opportunity Purpose' section, identify the specific types of clinical studies supported. Locate and extract the original Funding Opportunity Number (FON) that this NOFO reissued.
The agent successfully navigates to the detailed page for the 'BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)' funding opportunity. The agent states that the primary purpose is to encourage investigators to pursue translational activities and small clinical studies for recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain. The agent states that the NOFO specifically supports 'Significant Risk (SR) clinical studies that will require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants'. The agent states that the original Funding Opportunity Number (FON) that this NOFO reissued is RFA-NS-24-016.