As an IACUC member, I need to understand what constitutes a significant change to an approved animal care and use protocol and how to manage it. Please navigate to the 'Significant Changes' training modules and identify at least three distinct types of significant changes that require IACUC review, along with a brief description of each, as presented in the module titles or descriptions.
Navigate to 'https://olaw.nih.gov/'. Click on 'Education' (ID 294). Click on 'Training Modules' under the 'ICARE Project & Workshops' section (ID 404). Scroll down to the 'Significant Changes' section. Identify and list at least three distinct types of significant changes based on the titles of the modules listed under this section.
The agent successfully navigates to the 'Interagency Collaborative Animal Research Education (ICARE) Project – Training Modules' page. The agent identifies and lists at least three distinct types of significant changes from the 'Significant Changes' section, such as 'Significant Change Training for Researchers', 'Significant Changes to IACUC-Approved Protocols', 'Significant Changes: What the IACUC Administrator Needs to Know', or 'Significant Protocol Changes'.