I interpreted "Annihilation" as a meditation on the unstoppable Will-to-Power of nature and the metaphysics of cancer.,(reply>), The film, yes, the trilogy of novels NO. They were fundamentally about the existential implications of humanity’s growing desire to separate itself from the natural world to which it belongs yet cannot ever fully understand, and how that can be both empowering and extremely alienating, especially in the context of a environmental crisis. It’s also about the nature of nature itself and is a love letter to nature. The author of the books has said so many times.