I think it's tremendously important to count on the unconscious support of lateral development and innovation.  I believe, while it nothing is for certain, the progress towards a goal as large as interplanetary exploration by humans could be manifested not just by a single entity (like SpaceX or ESA) but by one inspiring 100 others.  Like how a paradigm shift could explode progress or co-operative efforts.  If life was detected on Europa or Encedalus, think of how that would propel efforts.  If the 35m ground-based telescope came about at the same time as fusion was managed and genetic manipulation shed some of its malevolence and Gateway made an artificial gravity station and micro-gravity science produced the first flourishing greenhouse in space and BNNTs plus a wall of water and reactive lasers made micrometerorites less of a hazard to hulls.  I believe we will live on other planets simply because I am confident more paradigm shifts similar to the internet/computer are on their way.  I don't need to fret about their manifestation during my lifetime.  Life will have its ups and downs, but we will survive.