I thought life origination is fairly well understood by now, not completely, but close enough that i don't think it is as huge of a mystery as the pre-Big Bang questions.<br><br>Also I think JWST did come up with detecting water around an exoplanet.,(reply>), @obiwan benobi to be honest I haven’t read up on the topic in a little while.  Are you saying an “RNA first,” hypothesis is no longer the front runner?,(reply>), @Tycho Station If you look into it more you'll see that they've made a fair amount of progress.  Once you have water and various elements mixing then you get films on bubbles and once you get those you get gradients ability to form on either side of thoee films.  From there you have energy gradients which can then be exploited.,(reply>), You talking abiogenesis?  No ones figured out how that process occurs in a natural environment or what all compounds can produce said result.