Alternative alte naive … humans living generations in outer space will be terrible mutants, totally unpredictable, as the caps that shield our DNA, the so-called Telomeres, get longer during spaceflight, and mutations were even found on cell-free DNA and RNA that was circulating in our human bodies’ bloodstream; and even while still in Earth’s orbit not too far out into space, we learned of immediate decreased body mass and increased folate, then the fact that mental faculties are massively affected already by microgravity in Earth’s orbit that much that the achievement of mental fitness in outer space was leading to mental fogginess and decrease in speed of thinking and low accuracy of the cognitive once back on Earth, plus arteries thicken as for lack of natural pressure and gravity, and elevated levels of proteins like the protein Aquaporin 2 which helps form the pathways used to carry water through cell membranes in the kidneys, turning human bodies in outer space literally into water balloons; and we learned that the human body was more prone to inflammation, increasing inflammations while in outer space, plus the changes to the microorganisms inside our guts, known as the microbiome, which are important in our overall health.