Good job, though hoping for more about steering reproduction. Instead of arguing for a gain of phenotype, perhaps a better argument for lab-selected reproduction is phenotype-rescue. One example would be the Danish Soccer player that had a heart attack at the last World Cup. General advice for genetic cardiomyopathies is to never do athletics. There should be a Human Constitution that have, as a right, to pursue athletics safely. That would be a good application for germline cell edits, with discussion about feasibility of multi-SNP edits. He oversold progress on reverse-engineering stem cells also, imho.