With modern day diets and modern day medicine which allows us to live longer, I think we are clearly seeing some shortcomings of the design of some of the body systems. For example kidney stones are formed in the kidney but then they have a 10-12 inch 2mm tube (the ureter) that they have to pass through to get to the bladder. If would have been better if the path to the bladder had been shorter and wider. Also heart muscle cells don’t regenerate unlike many other cells of other organs and with heart attacks part of normal life it would have been nice if heart cells repaired themselves. Why would the urethra in males pass though the prostate which grows and constricts that passageway in almost all males beyond 50. Perhaps in enough time evolution will adapt and evolve these systems to account for modern diet influences.