The great universal machine will know all that is to know, and will compress billions of years of new discoveries into nano seconds of almost infinite connections.  All forms and functions of life could be computed and machines could perform these functions in real life , more efficient new DNA, perhaps new types of neurons leading to a super intelligent immortal race of beings, new plants, animals, molds, fungi and forms of life yet to exist.  You may decide weather to remain human or to become genetically enhanced.  You maybe be able to choose which environment youd like to be enhanced for, water, high altitude mountains, planets with less or more gravity.  the physics driving Evolution on tap, physics driving the universe on tap.  With this said our machines computational capabilities will moon over their physical manipulating capabilities.  Once computing and physical manipulation have peaked we will have come to the final end of the physical deficiencies of civilization.  How will that effect the psychological problems of society?