Technically.... Binding of Issac fits this category.<br><br>Isaac is a cross dressing baby, its a story about him and his mother (2 characters," so <a href=""https://www.youtube.com/watch?v=dw9lmEp7Q6E&amp;t=50m50s"">50:50</a> gender)", there's powerups that give him disabilities, some characters start with different amounts of money, and it tackles many more themes.