Otohime's terrifying plot that involves all of Edo finally enters its final stage. Gintoki, Katsura, Shinpachi, Kagura and the others make every effort to stop her plans… How will this battle end? And what will be the fate of Earth?!
Fire the Anti-aging vaccine to destroy
the Aging virus ravaging the world!
Usen la vacuna antiedad para destruir 
el virus envejecedor que asola el mundo.
Lancem a vacina antienvelhecimento para
 destruir o vírus que assola o mundo!