Sanosuke's friend has died from an opium overdose. However, Kenshin and Sanosuke are perplexed at how he even got his hands on the drug, since opium is banned and too expensive for the average person to afford. Then a mysterious woman, Megumi Takani, appears before them. Kenshin and the others fight off Kanryu Takeda's private army who is trying to capture Megumi. However, Megumi is carrying opium...
It creates absolutely terrible
withdrawal symptoms,
،إنّه يتسبّب في إعراض انسحاب فظيعة جدًّا
Damals war es wegen der schrecklichen
Entzugserscheinungen, die es verursachte,
Desencadena
un síndrome de abstinencia espantoso.
Produce un terrible síndrome
de abstinencia.
Provoquant
de graves symptômes de dépendance,
उसका सेवन बंद करने पर
भयंकर लक्षण दिखाई देते हैं 
A causa dei terribili effetti
provocati dall'astinenza,
Из-за того, какую страшную
зависимость он вызывает,