Rutin- and Selenium-attenuated cadmium-induced testicular pathophysiology in rats.
Cadmium (Cd) is known to cause oxidative damage in the testes of rats. The aim of this study was to investigate the protective role of rutin (RUT, 30 mg/kg) and selenium (Se, 0.15 ppm) alone or in combination against Cd (200 ppm)-induced lipid peroxidation, steroidogenesis and changes in antioxidant defence system in the rat testes. The obtained results showed that Cd increased lipid peroxidation and abnormal sperm count and decreased plasma testosterone, lactate dehydrogenase, acid phosphatase, alkaline phosphatase and testicular steroidogenic enzymes: 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD activities as well as epididymal sperm counts and motility, while RUT and Se treatment reversed this change to control values. Acute intoxication with Cd was also followed by significantly decreased activity of the antioxidant defence system (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione (GSH), and glutathione-S-transferase (GST)). Treatment with RUT and Se reversed Cd-induced alterations of antioxidant defence system and significantly prevented Cd-induced testes damage and depletion of plasma and testicular Se levels. RUT and Se appear not to have more profound effects than their separate effects against Cd-induced testicular toxicity, although Se was more potent than RUT in the recovery of testosterone levels. These results suggest that both RUT and Se do not have synergistic role against Cd-induced testicular injury.
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Se rutin RUT testosterone RUT RUT Se Cd selenium Se Cadmium Cd Cd testosterone lactate 3β-hydroxysteroid RUT Se Cd superoxide glutathione RUT Cd GSH glutathione glutathione GSH glutathione S Rutin Selenium cadmium Se GST lactate dehydrogenase acid phosphatase alkaline phosphatase testicular steroidogenic enzymes 3β-hydroxysteroid dehydrogenase HSD 17β-HSD superoxide dismutase SOD Cd catalase CAT glutathione peroxidase GSH-Px glutathione reductase GR glutathione-S-transferase Cd Se RUT Se Cd