Gemcitabine and Pemetrexed disodium in treating breast cancer.
Pemetrexed disodium (Alimta, LY231514) is a novel, multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. This agent is broadly active in a wide variety of solid tumors, including breast cancer. Pemetrexed disodium has also shown clinically relevant activity in combination with gemcitabine (Gemzar). This combination is being evaluated for the treatment of metastatic breast cancer.
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CHEMICAL CHEMICAL GENE-Y GENE-Y GENE-Y CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL
Gemcitabine Pemetrexed disodium dihydrofolate reductase glycinamide ribonucleotide formyl transferase thymidylate synthase Pemetrexed disodium dihydrofolate glycinamide ribonucleotide formyl Alimta Pemetrexed disodium LY231514 gemcitabine Gemzar thymidylate