N2-acetylphenelzine: effects on rat brain GABA, alanine and biogenic amines.
The neurochemical properties of N2-acetylphenelzine were compared with those of phenelzine in a rat model. N2-Acetylphenelzine is a relatively potent inhibitor of monoamine oxidase-A and -B and causes increases in whole-brain levels of noradrenaline and 5-hydroxytryptamine, and decreases in homovanillic acid, 5-hydroxyindole-3-acetic acid, and 3,4-dihydroxyphenylacetic acetic after acute i.p. administration of the drug. Phenelzine is a more potent monoamine oxidase inhibitor than is N2-acetylphenelzine. The most marked difference in the profile was that N2-acetylphenelzine had no effect on whole brain levels of the amino acid neurotransmitters alanine and gamma-aminobutyric acid, whereas phenelzine caused dramatic increases. Acetylation of phenelzine at the N2 position presumably interferes with the inhibition of the transaminase enzymes for gamma-aminobutyric acid and alanine.
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CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-N GENE-N GENE-N CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL
monoamine N2-acetylphenelzine N2-acetylphenelzine amino acid alanine gamma-aminobutyric acid phenelzine phenelzine N2 phenelzine N2-Acetylphenelzine gamma-aminobutyric acid alanine N2-acetylphenelzine GABA alanine amines monoamine oxidase-A and -B monoamine oxidase transaminase monoamine noradrenaline 5-hydroxytryptamine homovanillic acid 5-hydroxyindole-3-acetic acid N2-acetylphenelzine 3,4-dihydroxyphenylacetic acetic Phenelzine