Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2.
Synthesis and structure-activity relationships of 7-O-p-cyanobenzoyl pyripyropene A derivatives with modification at C1 and 11 are described. Regioselective mono-deprotection of di-tert-butylsilylene acetal was critical in their synthesis.
T1 T2 T3 T4 T5 T6 T7
CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-Y
di-tert-butylsilylene acetal 7-O-p-cyanobenzoyl pyripyropene A acyl-CoA cholesterol pyripyropene A acyl-CoA:cholesterol acyltransferase 2 ACAT2