Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.
Dipeptidyl peptidase-IV (DPP-IV) is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). In this report, we show that the hypolipidemic agent atorvastatin is a competitive inhibitor of porcine DPP-IV in vitro, with K(i)=57.8+/-2.3 microM. These results may have implications in the development of novel DPP-IV inhibitors based on the use of atorvastatin as a lead compound for the treatment of type 2 diabetes.
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CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-N GENE-Y GENE-Y GENE-Y GENE-Y GENE-Y GENE-Y GENE-Y GENE-Y GENE-Y
atorvastatin atorvastatin atorvastatin Dipeptidyl peptidase-IV incretin hormones glucagon-like peptide-1 GLP-1 glucose-dependent insulinotropic polypeptide GIP DPP-IV porcine DPP-IV DPP-IV dipeptidyl peptidase-IV DPP-IV