Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor.
The effects of several cyclic adenosine monophosphate (cAMP)-elevating agents on the proliferation of cultured rat microglia were investigated by immunocytochemical staining with an antibody against proliferating cell nuclear antigen (PCNA). Epinephrine, isoproterenol, forskolin and 8Br-cAMP suppressed the microglial proliferation. A beta2-selective agonist terbutaline but not a beta1-selective agonist dobutamine mimicked the effect of the above cAMP-elevating agents. Furthermore, a non-selective beta-receptor antagonist oxprenolol and a beta2-selective antagonist acebutalol, but not a beta1-selective antagonist butoxamine, counteracted the suppressive effects of the beta-agonists on microglial proliferation. These findings suggest that the beta-agonists suppress the proliferation of microglia by elevating intracellular cAMP level through an action on beta2-adrenergic receptor.
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CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-Y GENE-Y GENE-Y
cyclic adenosine monophosphate Epinephrine isoproterenol forskolin 8Br-cAMP terbutaline dobutamine cAMP oxprenolol cAMP acebutalol butoxamine cAMP proliferating cell nuclear antigen PCNA beta2-adrenergic receptor beta 2-adrenergic receptor