Effect of minaprine on cycloheximide-induced amnesia in mice.
The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnesic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficial effect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).
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CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-N GENE-N
Minaprine minaprine cycloheximide scopolamine physostigmine cycloheximide minaprine cycloheximide serotonin 5-HT p-chloroamphetamine 5-HT 5-hydroxytryptophan 8-hydroxy-2-(di-n-propylamino)tetralin minaprine cycloheximide ritanserin minaprine cycloheximide minaprine cycloheximide 5-HT1A 5-HT2 5-HT2 receptors