Synthesis of C17-OH-north unit of ritterazine G via "Red-Ox" modifications of hecogenin acetate.
The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.
T1 T2 T3 T4 T5 T6 T7
CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL
OH ritterazine G hecogenin acetate OH OH ritterazine G hecogenin acetate