RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
Three retinol dehydrogenases (RDHs) were tested for steroid converting abilities: human and murine RDH 12 and human RDH13. RDH12 is involved in retinal degeneration in Leber's congenital amaurosis (LCA). We show that murine Rdh12 and human RDH13 do not reveal activity towards the checked steroids, but that human type 12 RDH reduces dihydrotestosterone to androstanediol, and is thus also involved in steroid metabolism. Furthermore, we analyzed both expression and subcellular localization of these enzymes.
T10 T11 T12 T13 T1 T2 T3 T4 T5 T6 T7 T8 T9
GENE-N GENE-N GENE-Y GENE-N CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-Y GENE-Y GENE-Y GENE-N GENE-Y
retinol dehydrogenases human and murine RDH 12 RDH12 retinol dehydrogenase androstanediol retinol retinol human RDH13 RDH12 murine Rdh12 human RDH13 RDHs human type 12 RDH