re hismanal et al side effects in article apr seas gwu edu sheryl seas gwu edu sheryl coppenger writes in article apr spdcc com dyer spdcc com steve dyer writes hismanal astemizole is most definitely linked to weight gain it really is peculiar that some antihistamines have this effect and even more so an antihistamine like astemizole which purportedly doesn t cross the blood brain barrier and so tends not to cause drowsiness the original poster mentioned fatigue i had that too but it was mostly due to the really bizarre dreams i was having i wasn t getting any rest my doctor said that was a common reaction if astemizole doesn t cross the blood brain barrier how does it cause that side effect any ideas it made me really bitchy for the first few weeks now that i think about it i was having some bizarre dreams too my doctor said it made him feel like he had to be doing something all the time but if you keep taking it after a few weeks these symptoms seem to go away he said hang in there i did and they did
