In this article we present the neuropsychological rehabilitation PAINT model and its effectiveness for persons with brain damage. Archival data of 20 patients with brain injury, who had been evaluated with the Luria-Nebraska Neuropsychological Battery, the Wechsler Adult Intelligence Scale (WAIS) and the Wechsler Memory Scale, before and after neuropsychological rehabilitation, were analyzed. All the patients underwent a holistic, intensive, multi-factorial, systemized and interdisciplinary rehabilitation program during a mean period of 10.2 months, directed toward the hierarchic rehabilitation of the damaged function and to the stimulation of the functions of all cerebral lobes, through formal tasks and activities of daily life. Analysis of clinically significance improvement indicates a high efficiency of treatment in overall neuropsychological functioning. WAIS subtests results show significant improvement in Picture completion, Arithmetic, Similarities. Luria-Nebraska scales performed significantly better in Visual, Tactile, Memory, Intellectual Processes, and Motor. Wechsler Memory Scale had a better outcome in Orientation, Associated word pairs, Logic memory. The multifactor intervention using the PAINT model for the rehabilitation of brain damage has proven to increase the recovery of not only the diminished function, but also the rest of the neuropsychological processes.