In this paper, we consider the design of a miniaturized proton-exchange membrane (PEM) fuel cell for powering 0.5–20W portable telecommunication and computing devices. Our design is implemented on a silicon substrate to take advantage of advanced silicon processing technology in order to minimize production costs. The reduced length scales afforded by silicon processing allow us to consider designs that would be prohibited by excessive Ohmic losses in larger systems. We employ a mathematical model to quantify the effects of the secondary current distribution on two competing cell designs. In addition to the design of the cell itself, we discuss key integration issues and engineering trade-offs relevant to all miniaturized fuel cell systems: air movement, fuel delivery and water balance, thermal management and load handling.