The present work is aimed at the optimization of a redox cell design. The studied redox cell consists on a device designed to convert the energy of reactants into electrical energy when a liquid electrolyte reacts at the electrode in a conventional manner. In this particular sort of cells, the two electrolytes are present and separated by a proton exchange membrane. Therefore, the flow of the electrolyte and the interaction with the membrane takes a paramount importance for the general performance of the cell. A methodology for designing the inlet part of the cell based on optimizing the uniformity of the flow and the initial position of the membrane is presented in this study. This methodology, based on the definition and optimization of several parameters related to the electrolyte flow in different regions of the geometry, is depicted. The CFD (Computational Fluid Dynamics) model coupled with the statistical study pointed to several practical conclusions on how to improve the final geometry construction of the redox cell. A particular case study of redox cell is implemented in order to validate the proposed methodology.