In this paper an empirical capacity fade model for Li-ion batteries has been developed, calibrated and validated for a NCA/C and a LFP/C Li-ion cell. Based on extensive experimental work, this original, generic model is well suited for system simulation approaches, and is able to describe both cycle and calendar effects on aging. The stress factors taken into account for each aging mode are the state of charge and the temperature for calendar aging, and the temperature and the current for cycle aging. A simple approach has been adopted in order to instantaneously apply either cycle aging or calendar aging according to operating conditions and thus accurately model aging effects due to dynamic operating conditions. This model has then been coupled to an electrothermal model and integrated in a system simulation software application in order to assess the effect of charging rates, charging strategies and V2G on battery lifetime. When compared, the two battery chemistries exhibited different behaviors when submitted to V2G scenarios. Light V2G scenarios caused relatively low aging for the LFP/C based battery but tended to slightly increase the aging of the NCA/C based battery according to simulations.