Publisher Summary A daunting bioethical challenge for engineers is that change is very rapid. Anything that changes rapidly is difficult to measure. Those who are engaged in the research and the practice of new technologies may not recognize the hazards and pitfalls. In fact, those directly involved in the advancement may be the worst at appraising its worth and estimating its risks. The innovators have a built-in conflict of interest that works against the ability to serve as society's honest brokers of emerging technologies. The difference between success and failure often hinges on very subtle hints in the design process. Every failure results from a unique series of events. Human factors must always be considered in any design implementation. In fact, the mathematics and statistics of failure analysis are very complicated, relying on nonlinear approaches and chaos theory, making use of nontraditional statistical methods, such as the Bayesian theory.