This paper presents a generalized methodology to evaluate the feasibility of photovoltaic-powered reverse osmosis (PVRO) systems for small, remote communities in challenging environments. The economic feasibility is determined by comparing the cost of water from a photovoltaic reverse osmosis system with the cost of water obtained using conventional diesel-powered reverse osmosis. For PVRO systems, the feasibility is a function of location due to variation in solar resource, water type, system demand and local governmental policies. A series of sample cases were analyzed to demonstrate the method. Analysis for community-scale seawater reverse osmosis systems was carried out for various locations using Geographic Information System (GIS) data. A site-specific analysis has been completed for seawater and brackish water reverse osmosis systems. It was found that photovoltaic-powered reverse osmosis is feasible for the majority of remote locations with a large solar resource.