The cold chain is one of the key elements of the preventive health-care delivery system. Vaccines have to be carried long distances, stored in remote places and during this period the temperature has to be maintained within certain specified values. Realizing the needs of such requirements, the Department of Science & Technology, New Delhi (Govt. of India) assigned a project to the R&D Division of MECON, Ranchi for development of Thermoelectric Cold-Chain Chest operated by 12 V DC vehicular battery. The resulting portable thermoelectric (i.e. Peltier effect) Cold-Chain Chest (TCC) operated successfully even in an ambient environment of 45 °C, mainly for preserving and transporting life-saving medicines for urban as well as rural areas.