A flexible self-powered e-skin has been presented with multi-functions of tactile-perception, atmosphere-detection and self-clean. Piezoelectric PVDF and tetrapod ZnO (T-ZnO) nanostructures are hybridizing on the flexible fabric substrate. The piezoelectric, gas sensing and photocatalytic properties of T-ZnO nanostructures are combined together. The piezoelectric effect of T-ZnO/PVDF leads to the motion-powered tactile-perception behavior, e.g. the e-skin can detect elbow bending or finger pressing. The piezoelectric/gas-sensing coupling effect of T-ZnO nanostructures delivers the motion-powered atmosphere-detection performance, and the piezoelectric output of the e-skin is different upon exposure to different atmosphere conditions, acting as the gas-sensing signal. The piezo-photocatalytic activity of T-ZnO nanostructures results in the distinct self-clean characteristics, and the organic-pollutants/bacteria can be degraded/sterilized on the surface of the e-skin. This novel material system and device architecture can promote the development of flexible self-powered multi-functional e-skin.