An extensive set of accelerated aging tests has been carried out employing a Li-ion high energy 18650 system (2.05 Ah), negative electrode: carbon, positive electrode: Li(NiMnCo)O2). It is manufactured by Sanyo, labeled UR18650E, and is a commercial off-the-shelf product. The tests comprise both calendar life tests at different ambient temperatures and constant cell voltages and cycle life tests operating the cells within several voltage ranges and levels using standard test profiles. In total, 73 cells have been tested. The calendar life test matrix especially investigates the influence of SOC on aging in detail, whereas the cycle life matrix focuses on a detailed analysis of the influence of cycle depth. The study shows significant impact of the staging behavior of the carbon electrode on cycle life. Furthermore a strong influence of the carbon potential on calendar aging has been detected. Observed relations between aging and the different influence factors as well as possible degradation mechanisms are discussed. Analysis of C/4 discharge voltage curves suggests that cycle aging results in different aging processes and changes in material properties compared to calendar aging. Cycling, especially with cycles crossing transitions between voltage plateaus of the carbon electrode seems to destroy the carbon structure.