The main objective of this study is to investigate the interrelation between life satisfaction, anxiety, depression, and hopelessness among Ankara University students. 364 university students completed a test battery including the Beck Depression Inventory, the Beck Anxiety Inventory, the Hopelessness Scale and the Satisfaction with Life Scale. Life satisfaction was negatively and significantly correlated with the scores from depression, anxiety and hopelessness scales. The findings suggest that the relationship between developing a psychological problems is highly associated the perceived levels of anxiety, depression and life satisfaction. In addition life satisfaction can be taken into account as a moderator variable for mental health studies.