Presenting Author details:ASchrein@jacde.jnj.com Raiffeisenstrasse 8, 41470 Neuss, Germany, Tel.: +49 213 7 955153. Background: This study reports data from a computerized cognitive test battery (Cogtest) applied in a control group of healthy volunteers and derives neurocognitive domain scores for future assessment of baseline deficits and cognitive changes associated with treating clinical populations. Methods: A computerized cognitive assessment was performed on a sample of healthy subjects in the United States with education and gender similar to patients from completed studies (treatment-resistant depression, schizophrenia) and stratified by age. Cognitive tests included Workstation Orientation, Auditory Number Sequencing, Object Working Memory, Continuous Performance Tests – Identical Pairs version and Flanker version, Face Memory, Word List Memory, Set Shifting, Strategic Target Detection, Penn's Emotion Acuity and Tapping Speed. Subjects were retested after approximately 4 weeks to assess prior exposure effects and test–retest stability. Results: In total, 124 healthy volunteers were studied with approximately 30 people in each of four age groups (mean age 49.5, range 18–87 years); 51.6% were female. For each test score, T-scores and age-adjusted T-scores were computed. T-scores were combined into domain scores (processing speed, attention-vigilance, reasoning problem solving, working memory, declarative memory and social cognition). A global Neurocognitive Composite Score was computed by averaging relevant T-scores. Age effects were found for most uncorrected T-score values, with expected linear effects at 18–65 years and an additional quadratic component reflecting steeper declines at older ages (>65 years). Overall test–retest reliability was high. Conclusion: The results from this control group of healthy volunteers offer a useful platform for analysis of patient-oriented research studies that use these cognitive tests. Acknowledgement: Supported by Ortho-McNeil Janssen Scientific Affairs, L.L.C.