This paper is concerned with the scientific change of nano-revolution with an aim to discuss and evaluate the scientific progress of nanotechnology in some Asian countries. Nanotechnology is now a science and technology (S&T) priority area for many Asian countries with the governments' efforts to put the results of nanotechnology development to commercialisation. The national policy for nanotechnology is to change the existing technology system and bring about an industrial revolution. Under the pressure of competition, the key to a success would lie in how each country could find the right application to focus on in order to survive through international competitions. This paper reviews specific targeted research activities of nanotechnology in some Asian countries—Thailand, Malaysia, Singapore, China, South Korea, Taiwan, and Japan. The paper finally recommends policy implications to encourage national innovativeness and effective commercialisation.