Publisher Summary This chapter reviews the findings of functional imaging of brain aging using two main approaches: studies of “resting” brain perfusion and metabolism; and activation studies. Aging affects the activation pattern underlying the process of encoding of faces; aged subjects do not show the right hippocampus and left prefrontal activation observed in young subjects. Also, the activation patterns do not differ significantly during the face recognition task, and there are no age differences in reaction time, but significant differences are found in recognition performances. Instead of the activation in the anterior prefrontal region observed in young subjects, elderly people show posterior frontal activation, in the vicinity of Broca's area. The statistical parametric mapping method has been used in aging studies to map the significant linear correlations between a given study variable and the age of the subjects. This method is highly suited for the investigation of the effects of aging on brain perfusion and metabolism because it allows a systematic, voxel-by-voxel analysis of the entire brain volume; a pictorial, visually straightforward representation of the findings; and a precise anatomical localization of the significant changes referenced to Talairach's system, permitting objective comparison between studies.