A 17-day pilot study investigating potential PM exposures of an elderly population was conducted near Baltimore, Maryland. Collection of residential indoor, residential outdoor, and ambient monitoring data associated with the subjects living at a common retirement facility was integrated with results from a paired epidemiological pilot study. This integration was used to investigate the potential pathophysiological health effects resulting from daily changes in estimated PM exposures with results reported elsewhere. Objectives of the exposure study were to determine the feasibility of performing PM exposure assessment upon an elderly population and establishing relationships between the various exposure measures including personal monitoring. PM2.5 was determined to be the dominant outdoor size fraction (0.83PM2.5/PM10 mass ratio by dichot monitoring). Individual 24-h PM1.5 personal exposures ranged from 12 to 58μgm−3. Comparison of data from matched sampling dates resulted in mean daily PM1.5 personal, PM2.5 outdoor, and PM1.5 indoor concentrations of 34, 17, and 17μgm−3, respectively. Activity patterns of the study population indicated a generally sedentary population spending a mean of 96% of each day indoors. Future studies would benefit from the use of a consistent sampling methodology across a larger number of PM measurement sites relevant to the elderly subjects, as well as a larger personal PM exposure study population to more successfully collect data needed in matched epidemiological-exposure studies.