An integrated stress model is developed to study the cycling effect on the commercial Li x C6 electrode, which has bridged the stress/strain analysis with the battery internal multi-transport processes. A Li x C6-Li y Mn2O4 cell is utilized as a physical base, and the battery charging-discharging induced SEI film growth are included in the model development. The important factors including depth of discharge, charging-discharging rate, cooling conditions, end of battery charge voltage as well as the particle packing pattern are investigated in the cycling operation. Results show that both the thermal stress and the chemical stress increase with the battery cycling, and the maximum local stresses are present in the middle of the Li x C6 particles and the interfaces. The potential of fracture can be raised by the elevated battery temperature and lithium concentration gradient. A denser packed Li x C6 electrode can reduce the maximum local stress in the electrode particles, and can improve the stability of the electrode structure in the cycling by flattening the local stress/strain distribution.