At present, stakeholders wishing to develop land use and management change scenarios at the landscape scale and to assess their corresponding impacts on water quality, biodiversity and economic performance, must examine the output of a suite of separate models. The process is not simple and presents a considerable deterrent to making such comparisons and impedes the development of more sustainable, multifunctional landscapes. To remedy this problem, we developed the Landscapes Toolkit, an integrated modelling framework that assists natural resource managers, policy-makers, planners and local communities explore options for sustainable landscape development. The Landscapes Toolkit links spatially-explicit disciplinary models, to enable integrated assessment of the water quality, biodiversity and economic outcomes of stakeholder-defined land use and management change scenarios. We use the Tully–Murray catchment in the Great Barrier Reef region of Australia as a case study to illustrate the development and application of the Landscapes Toolkit. Results show that the Landscapes Toolkit strikes a satisfactory balance between the inclusion of component models that sufficiently capture the richness of some key aspects of social-ecological system processes and the need for stakeholders to understand and compare the results of the different models. The latter is a prerequisite to making more informed decisions about sustainable landscape development. The flexibility of being able to add additional models and to update existing models is a particular strength of the Landscapes Toolkit design. Hence, the Landscapes Toolkit offers a promising modelling framework for supporting social learning and adaptive management through participatory scenario development and evaluation as well as being a tool to guide planning and policy discussions at the landscape scale.