The influence of an applied mechanical pressure on the electrochemical performance and the aging of 1.4 Ah graphite/NMC622 stacked Lithium-ion battery cells (LiBs) is investigated comprehensively on the electrode and the full cell level. Pressure dependent ionic pore resistance measurements reveal an increase of the ionic pore resistance in both, the anode and the cathode of 6% and 2.9%, respectively at a pressure of 0.84 MPa. Compressibility measurements expose an interesting nonlinearity of the compressibility and the number of layers in an electrode stack, which must be considered for the cell application. The applied pressure improves the electrical contact in the cell. However, by the increase of both, the ionic pore resistance and the charge transfer resistance, the reversible capacity loss is strongly dependent on the applied C-rate during the cycling. For C-rates above 0.8C the polarization losses of the compressed cells are around 7.3% in comparison to 2.1% for the uncompressed cells. Contrariwise, for C-rates below 0.8C the compression of the cells is beneficial and leads to a capacity increase of 2.0% compared to the uncompressed cells. The subsequent post-mortem analysis demonstrates the negative influence of the absence of a homogeneous pressure distribution within the uncompressed cells.