Background: The early positive component of MLAERPs, occurring between 35 and 90ms after the stimulus (P50), may reflect a preattentive stage of information processing, and has been widely evaluated in schizophrenia. Many studies have shown P50 gating deficits in schizophrenia patients. We explore the relationship between P50 sensory gating and neuropsychological measures. Methods: P50 gating was measured in hundred and sixty patients with schizophrenia (DSM-IV / SCID) and sixty four control subjects. All patients were community dwelling and clinically stable. Neuropsychological assessment. We used a neuropsychological battery described elsewere (Sanchez-Morla et al., 2009). Six cognitive domanins were examined: speed of processing, executive function, working memory, sustained attention, verbal memory and visual memory. Results: 1. The overall MANOVA (F(1,217)=34.3; p<0.0001) indicated significant differences in neuropsychological function among patients with schizophrenia and control group. 2. In the group of patients with schizophrenia, parametric and nonparametric correlations revealed no significant relationships between P50 gating and performance in any of the 21 primary neurocognitive variables and any of the 6 neurocognitive domains. Neither there was any significant correlation in the control group. 3. When compared neurocognitive measures (primary variables and domains) in patients among the lowest vs highest quartiles of P50 ratio, no significant differences were observed. Discussion: We failed to detect relationship between P50 gating and performance across neurocognitive measures. This lack of association is very consistent taking into account the substantial power afforded by this large cohort of patients with schizophrenia.