This paper reports the synthesis of highly loaded SnO2/mesoporous carbon (MC) nanohybrid through a facile chemical solution process and subsequent annealing methodology, by using a novel three-dimensional (3D) MC as a buffering and conducting matrix. Owing to its unique structural characteristics, the MC–SnO2 nanohybrid anode exhibits markedly improved cycling stability and rate capability compared to pure SnO2 nanoparticles, facilitating its application in advanced Li-ion batteries (LIBs) with long cycle life and high power density.