Intercalation/deintercalation of large size Na ion leads to serious electrode materials fragmentation that would be the main reason of Na-ion battery capacity fading. Herein, we reported a Na-ion battery cathode material composed of layer-structured VO2 (A) nanowires wrapped with graphene. The VO2 (A)/graphene nanostructure which effectively suppressed pulverization of VO2 (A) nanowires during cyclic charging and discharging exhibited prominent cycle stability and high specific capacity. A reversible capacity of 115 mA h g−1 was retained over 100 cycles at a high current density of 100 mA g−1. Comparing to the electrochemical performance of other vanadium oxides, VO2 (A)/graphene demonstrates a potential cathode material for Na-ion batteries.