Disease identification in public health monitoring routinely employs analyte detection systems capable of discriminating mixtures of analytes, toxins, cells and/or bacteria in medical and/or environmental solutions. The development of smart sensors capable of discriminating such compounds has become increasingly important for clinical, environmental, and health applications. While some sensors have been fashioned for single analyte detection, methods and systems that facilitate rapid screening of multiple clinical components are needed, serving as triggers for potential epidemics or more specific confirmatory testing. In public health applications, there is like need for immediate collection of geocoded data tagged by disease identification characteristics, with corresponding alerting capabilities. In this technology review we propose one promising model for using a combination of emerging systems-based technologies in multi sensor cartridges, integrated with GPS-enabled, alert-capable mobile phone devices.