Publisher Summary This chapter provides an insight into general principles associated with the transportation of hazardous substances. Transportation of a chemical between the supplier and/or agent and the user may introduce special risks in addition to those which can arise from the inherent chemical and physical properties. Comprehensive labeling and identification procedures and information supply aim to avoid any confusion over the nature of the chemical and recommended handling, storage, and emergency procedures. However, different parties have to oversee, and take responsibility for, the chemical at different stages during its movement between sites, for example loading/storage, transport by various methods, storage in transit, and unloading. Moreover, third parties can be prone to injury, and property or the environment can be subjected to damage if loss of containment occurs.