Layered structure LiNi0.8Co0.2O2 cathode material for lithium-ion batteries was synthesized by sintering the precursor, which was obtained from the corresponding metal acetate solution via a spray-drying method. The structure, morphology and reaction mechanism of the powders were characterized by means of XRD, SEM and TG-DTA. The electrochemical properties of the LiNi0.8Co0.2O2 cathode were also investigated by using a coin-type cell containing Li metal as the anode in a potential range of 3.0–4.3V. Upon sintering the spray-dried powders at 750°C for 24h, the LiNi0.8Co0.2O2 particles obtained are fine, narrowly distributed and well crystallized. As a result, the synthesized LiNi0.8Co0.2O2 has excellent electrochemical properties. The simple synthesis procedure is time and energy saving, and thus is promising for commercial application.