Background: The purpose of the present study was to characterize the association between cognition, clinical symptoms and social functioning and anatomical cerebral deficits in a sample of schizophrenia outpatients using voxel-based morphometry (VBM). Methods: Participants were 6 schizophrenia outpatients and 8 matched (sex ,age) healthy comparison subjects. Both patients and healthy controls were assessed using VBM. Cognitive status was assessed by standardised neuropsychological test battery. Psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Social functioning was assessed using Life Skills Profile (LSP). Results: (preliminar results) Decreased gray matter volume was observed in schizophrenia patients in left medial temporal gyrus, left insula and bilateral superior temporal gyri (uncorrected data). Discussion: These preliminar findings revealed volume loss in the the left medial temporal gyrus, left insula and bilateral superior temporal gyri in schizophrenia outpatients.