In view of the high theoretical specific capacity of 946 mAh/g, Sb2S3 anode materials have been considered as competitive candidates for high performance lithium ion batteries (LIBs). However, pure Sb2S3 usually suffers from inferior cyclicity because of the extremely large volume expansion upon Li+ uptake and release processes when applied as electrode in LIBs. Combining Sb2S3 with carbonaceous materials would reduce the volume change effect and thus maintains high capacity and substantially improves the cycling performance. Herein, ultrafine Sb2S3 nanoparticles embedded in mesoporous hollow carbon spheres (MHCS) are successfully prepared based on a facile hydrothermal method using MHCS as the microreactor for lithium ion storage, which delivers a desirable specific capacity of 745.3 mAh/g at a current density of 100 mA/g after 160 cycles, and displays prominent rating capability. The outstanding electrochemical performance is due to the mesoporous and unique hollow feature of MHCS, which not only facilitates the electron transfer and Li+ diffusion, but also confines the growth of Sb2S3.