Introduction: The aim of this research was to investigate whether a battery of musculoskeletal tests could be used to prospectively identify injuries in Australian first class cricketers. Methodology: Musculoskeletal physiotherapy screening procedures consisting primarily of measures of joint range of motion were standardized across 6 states. These were then performed pre-season over 3 consecutive seasons from 2006–2008 giving 121,102 and 123 screens respectively. This information was then collated with injury surveillance data over the course of the three seasons and univariate (one way ANOVA) and multivariate (discriminant analysis) statistics were performed to determine whether it was possible to predict lower back/lower limb injury based on the screening results. Results/Conclusions: Players who suffered from lower back or lower limb injury were found to have significantly reduced left hip external rotation (p=0.002) and left ankle dorsiflexion (p=0.005) compared to the non injured group. They also exhibited significantly increased right 1st metatarsophalangeal extension (p=0.01) and shoulder/thoracic extension in prone (p=0.002). Using these variables it was possible to correctly classify 72% of the players into the injury and non injury groups. These results suggest that reduced range of hip and ankle motion may adversely affect the lower kinetic chain. In contrast, the excessive motion in the foot and through the thoracic region may represent an adaptation to reduced motion in other regions. These results also provide direction for rehabilitation programs designed to reduce injury and provide a means for monitoring the physical status of cricket athletes over the course of a season.