Schultheis MT, Manning K, Weisser V, Blasco A, Ang J, Wilkinson ME. Vision and driving in multiple sclerosis. Objective To examine the relationship between measures of visual dysfunction and driving performance in persons with multiple sclerosis (MS). Design Between-group comparison. Setting All data were collected in an outpatient research setting. Participants Persons (N=66) with MS of the relapsing remitting type (26 self-reporting visual difficulties; 40 self-reporting no visual difficulties) and 26 age- and sex-matched healthy controls. Interventions Not applicable. Main Outcome Measures Measures of vision included visual acuity, depth perception, and color perception. Driving was measured using documented accident/violation rate and self-reported driving behaviors. Results Quantitative analysis only revealed that MS persons with self-reported visual difficulties performed significantly worse than healthy controls on color perception (Kruskal-Wallis; χ2 2=8.89, P=.01). There were no group differences on driving behaviors, and correlational analysis revealed a lack of relationship between the selected visual (visual acuity, depth perception, color perception) and driving performance measures (documented accident/violation rate and self-limiting driving behaviors). Conclusions Persons with MS who self-reported difficulties with vision had acceptable visual acuity, despite demonstrating impairment in color perception. The fact that visual acuity remains the most common measure for visual fitness to drive remains problematic. There is a need to further define measures of visual dysfunction relevant to driving among this clinical population.