The reconstruction of a damaged historic/modern urban system following a natural catastrophic event, even if sophisticated, complex and expensive can become an opportunity to apply innovative methods of urban regeneration oriented towards environmental sustainability. A research by the University of L'Aquila exploring the consequences of the 2009 earthquake in central Italy, both in analytical and design terms, is focused on this theme, applying innovative principles to the reconstruction project of the city of L'Aquila, capital of the Abruzzo Region (Italy). The study carries out an analysis of the earthquake effects on urban systems and mobility and proposes an operating strategy based on a multidisciplinary approach that integrates urban design and sustainable mobility strategies. In particular, it outlines the components of Strategic Projects that has been developed for the reconnection of the urban fragments created by the dispersion of the city after the earthquake, which has applied the principles of multi-modal sustainable mobility. The results of the study show that the post-quake reconstruction, if properly interpreted, can be a unique opportunity to conceive and construct the conditions to implement a new and more efficient urban sustainable transport model through advanced technologies based on outlining an innovative urban redesign approach.