This study investigates how the quadruple helix (QH) innovation model functions in a regional renewable energy initiative in Uppsala, Sweden. The focus is on the collaboration between regional office representatives, researchers, consultants and civil society, and their involvement in the attempt to implement and commercialize an innovation within renewable energy for the renovation of an old bridge. The empirical material gathered for this study was based on interviews, conversations, and participant observation during workshops and meetings with different stakeholders. By applying a processual approach, this article illustrates how the QH configuration (university-industry-government and civil society) emerges and evolves, unfortunately into a failed collaboration and thus a closing down of a commercialization attempt. By analyzing interactions and events of the process, we discuss the coordination problems between the actors to better understand how the dynamics affect local governments’ attempts to spur a more innovative climate in the region. In our conclusion, we discuss how the processual approach, when applied, can offer a better understanding of the uncertain development of QH projects in knowledge-based societies and economies.