 Recently, the use of polymer-supported bimetallic catalysts to reduce the cost of direct methanol fuel cells (DMFCs) and increase the efficiency of catalysts has been considered. In this work, the preparation of platinum–palladium supported on polyaniline-doped camphorsulfonic acid/graphene (Pt–Pd@ PANI-CSA/graphene) nanocomposites as an anode material in DMFCs is reported. PANI-CSA/graphene nanocomposite was prepared from aniline-doped CSA and graphene by in situ polymerization in ice water. In order to characterize the structure and the surface properties of prepared materials, Fourier transform infrared spectrum (FTIR), X-ray diffraction spectroscopy (XRD), and scanning electron microscopy (SEM) techniques were employed. The electrochemical properties of the nanocatalysts were evaluated through cyclic voltammetry (CV) and chronoamperometry (CA) measurements. The results suggested that PANI-CSA/graphene nanocomposite as a support material had an especially positive effect on the electrocatalytic activity of Pt–Pd for methanol oxidation reaction (MOR) in alkaline media. Also the results of chronoamperometric studies showed that Pt–Pd@ PANI-CSA/graphene was more stable than unsupported Pt–Pd for methanol electrooxidation.