We proposed and tested a new and novel arrangement for a direct methanol fuel cell consisting of one inlet for a methanol solution and four outlets for oxidant gas (air), in both the anode and cathode flow fields. It utilizes different operating temperatures of 40°C and 60°C, and different methanol solution flow rates of 5mlmin−1, 10mlmin−1, and 20mlmin−1. Test results indicate a significant reduction in produced CO2 gas in the anode flow channels and product water in the cathode flow channels; consequently, cell performance can be greatly improved. Furthermore, methanol crossover can also be avoided and reduced.