The current research tried to investigate the differences in the strategies and Coping Reactions in relation to the Control Source among individuals.In this correlational research, 70 Epilepsy Patients were selected randomly and invited by the East Azerbaijan Epilepsy Association to the central building. Then the Router s’ Control Source test and Billing and Mousse s’ Coping Reaction questionnaire were distributed among them.A significant relationship was found between the Control Source and each of the Coping Reaction s’ different variables (cognitive, inhibitory and behavioral) among the Epilepsy Patients (p<0.05). Moreover, the Control Source can significantly predict each of these three Coping Reactions.The results of this study confirm the hypotheses that claim the existence of a relationship between the psychological variables(Control Source)and Coping strategy. Moreover, these results can be beneficial to those researchers that are trying to find some patterns based on the prevention and treatment of behavioral and psychological disorders.