The redox behavior of the polypyrrole films in the presence of LiClO4 salt in different solvents like propylene carbonate (PC), N,N-dimetilformamide (DMF), methanol (MetOH), ethanol (EtOH), acetonitrile (ACN) and water was investigated using simultaneous electrochemical quartz crystal microbalance and cyclic voltammetry experiments. Both charge and mass changes during redox processes were rationalized in terms of multiple regression considering some solvent parameters and ionic transport characteristics. The electroactivity of PPY modified electrodes increase in the sequence PC<DMF<EtOH<MetOH<ACN<water. Also the mass gains in the sequence PC<water<EtOH<DMF<MetOH<ACN, showing clearly the influence of the solvent physico-chemical nature on the electroactivity and electroneutralization processes.