A large number of stand-alone power systems that are based on fossil fuel or renewable energy (RE) based, are installed all over Europe. Such systems, often comprising photovoltaics (PV) and/or diesel generators provide power to communities or technical installations, which do not have access to the local or national electricity grid. The replacement of conventional technologies such as diesel generators and/or batteries with hydrogen technologies, including fuel cells in an existing PV-diesel stand-alone power system providing electricity to a remote community was simulated and optimised, using the hybrid optimisation model for electric renewables (HOMER) simulation tool. A techno-economic analysis of the existing hybrid stand-alone power system and the optimised hydrogen-based system was also conducted. The results of the analyses showed that the replacement of fossil fuel based gensets with hydrogen technologies is technically feasible, but still not economically viable, unless significant reductions in the cost of hydrogen technologies are made in the future.