Mycoremediation is one of the biotechniques that recruits fungi to remove toxic pollutants from environment in an efficient and economical manner. Mushrooms, macro-fungi, are among the nature’s most important mycoremediators. Pleurotus species (also called oyster mushrooms) are considered to be the most popular and widely cultivated varieties worldwide and this might be attributed to their low production cost and higher yields. Apart from their nutritive and therapeutic properties, Pleurotus species have high biosorption potential due to their extensive biomass, i.e. mycelial production. The genus has been reported to accumulate high levels of heavy metals. The current state-of-the art review mainly summarises previous investigations carried out by researchers on different roles and mechanisms played by Pleurotus species on heavy metals mycoremediation.