Abstract The final chapter of this book gives a review on the status of the direct alcohol fuel cell technologies and foresees the research and development trends for the next future. A section devoted to advanced modeling includes two-dimensional and three-dimensional modeling and the new trend one-dimensional plus two/three-dimensional modeling. This section precedes a comparison between the different technologies available for portable applications, DAFCs, and Lithium batteries. The DAFCs codes and standards and environmental effects, emissions, and Life Cycle Assessment are briefly addressed. The chapter ends pointing out the remaining challenges and outlining the next decade. In what concerns portable applications, DAFC can compete with batteries, but the research on these systems must be directed toward the operation with higher fuel concentrations or even pure fuel (alcohol crossover needs to be reduced) to take advantage of the high alcohols′ specific energy and to reduce the system volume and weight.