Q-interactive is a digital system built to support and enhance a clinician’s use of individually administered tests such as the WISC-V. This type of computer-assisted testing is distinct from the more familiar computer-administered testing in which the examinee sees test items on a computer screen and answers using a keyboard, mouse, or touchscreen. This chapter describes the Q-interactive system, explains how it was conceived and developed, gives an overview of its research base including findings for the WISC-V, and explores some of the implications of the system for the science and practice of clinical assessment.