Hierarchical hollow CuS@MoS2 microcbues are prepared via an effective strategy. The synthesis mechanism of hollow CuS@MoS2 microcubes is based on the transformation from Cu2O to CuS and the precipitation formation of MoS2 at the same time. The hollow microspheres are characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. CuS@MoS2 hollow microcbues can deliver a reversible specific capacity of 912mAhg−1 after 200 cycles at a specific density of 500mAg−1, and maintain good rate capability from 500 to 4000mAg−1. This hollow frame contributes greatly for the alleviation of mechanical stress during electrochemical cycling, and buffers volume change of active materials. Meanwhile, hollow structure shortens the diffusion distance of lithium ions, and thus is beneficial for its rate performance. Furthermore, hybrid materials are also a valid way to improve the electrochemical property of transition metals sulfides. Therefore, the prepared CuS@MoS2 microcubes present enhanced electrochemical performance. The reported strategy is general, fast and can also be possibly applied for the fabrication of other advanced hollow materials used in the energy and environmental filed.