Mebarid®, an ayurvedic formulation, was tested for its anti-diarrhoeal, anti-ulcer and anti-motility activities in animals. Mebarid® was investigated at four dose levels of 125, 250, 500mg/kgBW and 1g/kgBW The methods of castor oil-induced diarrhoea and pylorus-ligation-induced ulcers in rats were used to evaluate the anti-diarrhoeal and anti-ulcer activity, respectively, while charcoal meal test in mice was the method used for testing its anti-motility effect. Mebarid® was found to have significant activity in all the three models. Thus, it can be concluded that Mebarid® possesses anti-diarrhoeal, anti-motility and anti-ulcer activities and can prove beneficial in the treatment of above gastrointestinal disorders.