We have expanded and implemented an algorithm for selecting power supplies into a turnkey MATLAB code, “POWER” (power optimization for wireless energy requirements). Our algorithm uses three approaches to system design, specifying either: (1) a single, aggregate power profile; (2) a power system designed to satisfy several power ranges (micro-, milli- and Watt); or (3) a power system designed to be housed within specified spaces within the system. POWER was verified by conducting two case studies on hearing prosthetics: the TICA (LZ 3001) (Baumann group at the Tübingen University) and Amadeus cochlear implant (CI) (WIMS-ERC at the University of Michigan) based on a volume constraint of 2cm3. The most suitable solution identified by POWER for the TICA device came from Approach 1, wherein one secondary cell provided 26,000 cycles of 16h operation. POWER identified Approach 2 as the solution for the WIMS-ERC Amadeus CI, which consisted of 1 cell for the microWatt power range and 1 cell for the milliWatt range (4.43cm3, ∼55% higher than the target volume), and provided 3280 cycles of 16h operation (including re-charge of the batteries). Future work will be focused on continuously improving our present tool.