Abstract This chapter examines the manner in which CO2-derived fuels, synthesised using renewable energy, can help with decarbonisation of several sectors. Three areas are discussed: the electrical generation system, transport fuels and energy for heating. In addition, the advantages and disadvantages of such CO2-derived fuels are considered with respect to other energy storage technologies. An introduction to the variations in daily demand on an electrical grid is illustrated by considering a single day experienced by the Spanish grid and the concept of a “generation mix” is presented. Synthetic fuels for transportation are explored alongside alternatives to the internal combustion engine, such as fuel cells and batteries. Finally, the area of heat provision, where CO2-derived fuels can be expected to play a vital role is introduced.