This work presents a novel fuel sensor-less control scheme for a liquid feed fuel cell system that operates under dynamic loading conditions and is suitable for portable power sources. The proposed technique utilizes the operating characteristics of a fuel cell, such as voltage, current and power, to control the supply of liquid fuel and regulate its concentration. As verified by systematic experiments, this scheme controls effectively the supply of fuel under dynamic loading conditions and pushes the system toward higher power output. The primary features and advantages of sensor-less fuel control are as follows. When the fuel concentration sensor is excluded, the cost of a liquid feed fuel cell system is decreased and system volume and weight are reduced, thereby increasing specific energy density and design simplicity, and shortening system response time. Notably, temperature compensation for measurement data is unnecessary. With a decreased number of components, the control scheme improves durability and reliability of liquid feed fuel cells. These advantages will help commercialization of liquid feed fuel cells as portable power sources.