The relevance of behavioral endpoints in animal seizure models to clinical epilepsy is outlined and enhanced in the present review by linking specific preclinical dependent measures with a quality-of-life scale that serves as an index of the health and welfare of patients with epilepsy (Quality of Life in Epilepsy inventory). This preclinical-to-clinical translation is possible based on existing literature within at least three behavioral domains: (1) physical and motor actions, (2) affective and emotional responses to environmental challenge, and (3) social, sexual, and parental functions. Face valid commonalities in observable behaviors are emphasized with the goal of engaging basic and applied researchers in collaborative research projects to accelerate the pace of discovery in the behavioral phenotyping of epilepsy field.