Those with more severe symptomatology had more metabolic abnormality and shorter slow wave sleep (SWS). Our findings suggest clinical symptoms as linked with heavier body weight, wider neck circumference, elevated blood pressure, and shorter SWS. Further studies are warranted to confirm the preliminary finding and to elucidate the underlying mechanism
Schizophrenia, a psychiatric disorder causing deterioration of cognitive and daily function, is associated with obesity and metabolic syndrome, rendering patients vulnerable to morbidity and mortality[1].1 Biological factors, lifestyle, and antipsychotics all contribute to obesity of patients[2], [3], which influences their sleep quality[4]. Prevalence of poor sleepers among schizophrenics is around 45%, related to adverse events of medication and accompanying depression and psychological distress [5], [6]. Metabolic abnormality and sleep disturbance seem correlated. Consequently, these patients reportedly have poor life quality; correlation between clinical symptoms and sleep quality remains unclear. We hypothesize patients with severe clinical symptoms as more likely to have metabolic abnormality and sleep disturbance.
