This paper presents a novel lithium-ion cell model, which simulates the current voltage characteristic as a function of state of charge (0%–100%) and temperature (0–30 °C). It predicts the cell voltage at each operating point by calculating the total overvoltage from the individual contributions of (i) the ohmic loss η 0 , (ii) the charge transfer loss of the cathode η CT,C , (iii) the charge transfer loss and the solid electrolyte interface loss of the anode η SEI/CT,A , and (iv) the solid state and electrolyte diffusion loss η Diff,A/C/E . This approach is based on a physically meaningful equivalent circuit model, which is parametrized by electrochemical impedance spectroscopy and time domain measurements, covering a wide frequency range from MHz to μHz. The model is exemplarily parametrized to a commercial, high-power 350 mAh graphite/LiNiCoAlO2-LiCoO2 pouch cell and validated by continuous discharge and charge curves at varying temperature. For the first time, the physical background of the model allows the operator to draw conclusions about the performance-limiting factor at various operating conditions. Not only can the model help to choose application-optimized cell characteristics, but it can also support the battery management system when taking corrective actions during operation.