
Restoration for bone injuries created by infections, complicated fractures, and resection surgery which may require massive transplanted bones, has always been a quite complicated procedure that involves a battery of biological events [1]. Currently, alternative structures have traditionally been fabricated from autologous, heterologous or even synthetic materials [2]. Among them, the autologous is recognized to be the “gold standard” owing to its superior osteogenesis, living tissue with intact cells and conductive scaffold that supports and integrates with the original bone tissue with perfection. Nevertheless, the autologous method is not without its disadvantages. Autologous bone obtained from patients could cause donor site infection, persistent pain and other complications [3]. Without affecting the normal structure and function of donor site, the number of autologous bone is too restricted to meet the demand of clinical treatment [4]. Correspondingly, massive researches have concentrated on new biomaterials for replacing traditionally used materials as quickly as possible or ameliorating their properties of bone regeneration with greatness [5]. Furthermore, natural polymers have attracted most attention owing to their good biocompatibility.
