Small bowel lipomas are rare gastrointestinal (GI) benign neoplasms, representing approximately 2–3% of nonmalignant tumors of the intestinal tract. They are usually asymptomatic. However, lesions exceeding 2 cm in diameter can cause nonspecific clinical manifestations or symptoms. When symptoms are clinically present, one of the most common is obscure GI bleeding. Capsule endoscopy is the first-line diagnostic tool in most cases with obscure GI bleeding. Recently, a video capsule for colon evaluation (second-generation colon capsule endoscopy (CCE2)) has been released (PillCam Colon; Given Imaging, Yoqneam, Israel) that potentially offers the opportunity to explore both the small bowel and the colon during one examination. Here is demonstrated capsule endoscopy visualization of a giant lipoma that caused a longstanding obscure GI bleeding. This article is part of an expert video encyclopedia.