The prevalence of mental disorders is growing in Europe. It is important to identify persons at risk, screen them and undertake a triage for stepped care procedures (DMP) for ambulatory and inpatient treatments. A responder/non-responder-analysis should identify those patients who could benefit from the different treatment procedures and who need specialised and intensive psychosomatic and psychtherapeutic care, also to be cost efficient. We therefore looked at characteristics, diagnoses, treatment histories, symptom load, motivational and social factors, personal traits, strain and stresses, regulation capacities, psychobiological features and other aspects in 3825 patients, who were administered to a newly founded Centre of Excellence for Psychosomatics and Psychotherapy in Austria. All patients were diagnosed according ICD-10 and DSM-IV, answered questionnaires within a standardised core battery, underwent somatic and psychological diagnostic procedures and then received treatments according to the international guidelines for mental and psychosomatic disorders. We closely looked at effect sizes of the treatments on different levels and administered a modified regression analyses (GAM), as well as additional factor and latent cluster analysis, to identify factors and moderator variables predicting therapeutic outcome. Symptom load, dimensions of personality and interpersonal problems are critical factors in predicting outcome.