Abstract Hybrid materials produced via the combination of functional polymers with inorganic nanostructured compounds, with the latter exhibiting size-dependent physical and chemical properties, have become a major area of research and technological development. The introduction of metal oxide nanoparticles in the polymeric nanocomposites has attracted the attention of researchers as advanced technological materials because of their unique optical, electronic, mechanical, and structural characteristics. This chapter mainly focuses on the preparation, properties, characterization, and applications of poly(vinyl chloride)/metal oxide composites. Also, the various manufacturing techniques, analysis of morphology, filler dispersion, interfacial interactions, etc. have been described.