 For the first time, Nd-MOF nanostructures were synthesized using a novel ultrasonic procedure. The final products were characterized by relevant techniques of X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, differential scanning calorimetry, Fourier-transform infrared spectroscopy, energy-dispersive X-ray mapping analysis, nuclear magnetic resonance, vibrating sample magnetometer, photoluminescence, and Brunauer–Emmett–Teller (BET) surface area analysis. Results showed that using ultrasonic irradiation can produce Nd-MOF samples with desirable physicochemical properties. It was found that the Nd-sample synthesized in optimum conditions has a high surface area of 1649 m2 g−1. This value expands the application of these novel materials in different fields such as electrochemical applications. The electrochemical cyclic voltammetry method was employed to study the behavior of DA on the proposed modified electrode. The results revealed high yields of these compounds in the electrooxidation of dopamine. The efficient synthesis route, novel physichochemical properties, and potential electrochemical applications developed in this study can be used as a novel protocol for other MOFs.