Cameroon is blessed with a vast potential of renewable energy resources: solar, biomass, hydropower, wind and geothermal energies. These resources are currently poorly valorized. The country depends mainly on hydropower for its electricity supply and traditional biomass for its energy consumption. This dependency on hydropower causes acute power shortage nationwide, especially in remote communities where grid access is limited. Rural electrification is mainly conducted through costly grid extensions, small hydro and diesel plants with enormous health and environmental effects. This study assesses the feasibilities of hybrid renewable power systems for remote applications in Southern Cameroons using the climate data of Wum. HOMER was used to perform the comparative analysis. Nine hybrid systems were considered in this study based on the following components: PV module, wind turbine, micro-hydro turbine, diesel generator, battery, charge controllers, and inverters. Two energy sources and storage battery characterized each system. The PV/diesel/small hydro/battery was found to be the most viable economic system for Southern Cameroons with a 0.443$/kWh energy cost. The optimum system was proven to be very resilient to variations in streamflow, interest rate, fuel price, and PV cost. This outcome was found to be highly relevant to policy makers and investors in Cameroon.