This study investigates the possibility of using and developing hydrokinetic power to supply reliable, affordable and sustainable electricity to rural, remote and isolated loads in rural South Africa where reasonable water resource is available. Simulations are performed using the Hybrid Optimization Model for Electric Renewable (HOMER) and the results are compared to those from other supply options such as standalone Photovoltaic system (PV), wind, diesel generator (DG) and grid extension. Finally the paper points out some major challenges that are facing the development of this technology in South Africa.