Design , synthesis and biological evaluation of new classes of thieno [ 3,2-d ] pyrimidinone and thieno [ 1,2,3 ] triazine as inhibitor of vascular endothelial growth factor receptor-2 ( VEGFR-2 ) .
O O O O O O O O O O B-MAT I-MAT I-MAT I-MAT I-MAT O B-MAT I-MAT I-MAT I-MAT I-MAT O O O O O O O O O O O O