A Comprehensive Look at HIV-Related Fatigue Fatigue, also known
as asthenia or prostration, is an unusual and prolonged
tiredness, exhaustion, or lack of energy. It often develops
slowly and worsens over time. Fatigue may be intermittent or
chronic. Chronic fatigue is persistent exhaustion that is not
associated with exertion and that may not be relieved by rest.
According to Lisa Capaldini, M.D., of the University of
California at San Francisco (UCSF), fatigue can be divided into
physical, psychological, and emotional components. Physical
fatigue is associated with activity. People with this type of
fatigue may experience muscle weakness, limb heaviness, or
soreness. They may be unable to perform daily physical tasks
such as shopping or preparing meals; those with severe fatigue
may even find it difficult to get out of bed or carry on a
conversation. Physical fatigue is often related to a specific
physical malfunction, such as heart, lung, endocrine (hormone),
or nervous system problems. People with psycholo