So, do we have a skeletal fluorosis epidemic on our hands? If
not, why? Telling me that a substance can cause bad effects at
chronic high-doses is not telling me anything at all, because
poison = dose. I am highly skeptical about the dangers of
fluoride, but it's also difficult to find non-ADA sponsored
studies about it. However, while access to fluoridated drinking
water has positive effects on dental health, the characteristics
of fluoride metabolism mean that fluoride consumption may have
implications for the kidney. The calcified tissues in the human
body contain 99% of the body burden of fluoride and most of this
is non-exchangeable. Absorption of fluoride is rapid and
extensive, with about 50% of the absorbed fluoride becoming
associated with calcified tissues within 24 h and the remainder
being excreted in the urine. In infants and young children, the
amount of fluoride retained in calcified tissues is >50% of the
ingested daily amount. The renal clearance of fluoride is high,
around 30–40 ml/min in he