In enzymology, an isovaleryl-CoA dehydrogenase (EC
126.96.36.199) is an enzyme that catalyzes the chemical reaction
- 3-methylbutanoyl-CoA + acceptor 3-methylbut-2-enoyl-CoA +
reduced acceptor Thus, the two substrates of this enzyme are
3-methylbutanoyl-CoA and acceptor, whereas its two products are
3-methylbut-2-enoyl-CoA and reduced acceptor. This enzyme
belongs to the family of oxidoreductases, specifically those
acting on the CH-CH group of donor with other acceptors. The
systematic name of this enzyme class is 3-methylbutanoyl-
CoA:acceptor oxidoreductase. Other names in common use include
isovaleryl-coenzyme A dehydrogenase, isovaleroyl-coenzyme A
dehydrogenase, and 3-methylbutanoyl-CoA:(acceptor)
oxidoreductase. This enzyme participates in valine, leucine and
isoleucine degradation. It employs one cofactor, FAD. Structural
studies  As of late 2007, only one structure has been solved for
this class of enzymes, with the PDB accession code 1IVH.