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| Unverricht-Lundborg disease (abbreviated ULD or EPM1) is the
most common form of an uncommon group of genetic epilepsy
disorders called the progressive myoclonus epilepsies. It is
caused due to a mutation in the cystatin B gene (CSTB). The
disease is named after Heinrich Unverricht, who first described
it in 1891, and Herman Bernhard Lundborg, who researched it in
greater detail in 1903. ULD onsets in children between the ages
of 6 and 16; there are no known cases in which the person was
older than 18. Most cases originate from the Baltic region of
Europe, though many have been reported from countries in the
Mediterranean. Onset of the disease is characterized by
myoclonic jerks and tonic-clonic seizures. Early cases often
resulted in the need of a wheelchair and death before the age of
24, but new treatments and medications have increased the life
expectancy of individuals with ULD, i