Source Newsroom: University of Michigan Health System Newswise —
ANN ARBOR, Mich. – A University of Michigan Health System study
provides new clues about the health-damaging molecular changes
set in motion by eating high-fat foods. A better understanding
of the body’s response to indulgent eating could lead to new
approaches for treating diabetes and metabolic syndrome. High-
fat foods can contribute to obesity, which increases the risk
for developing type 2 diabetes. The researchers learned a key
protein called Bcl10 is needed for the free fatty acids – which
are found in high fat food and stored in body fat -- to impair
insulin action and lead to abnormally high blood sugar. In the
laboratory study, mice deficient in Bcl10 were protected from
developing insulin resistance when fed a high-fat diet. The
findings will be published May 31 in Cell Reports. Insulin helps
control blood sugar, but insulin resistance can lead to the
abnormally high blood sugar levels that are the hallmark of
diabetes. Insulin resista