Gonococcal infections, including urethritis, cervicitis,
epididymitis, and proctitis, are a significant cause of
morbidity among sexually active men and women. The treatment of
these sexually transmitted infections (STIs) has evolved over
the years, mainly due to the emergence of antibiotic resistance.
Urogenital, anogenital, pharyngeal, and ocular gonococcal
infections that are not associated with bacteremic or ascending
spread of the pathogen to other organs are considered
uncomplicated. This topic will address the treatment of these
gonococcal infections, with a focus on urogenital infections. In
2012, the United States Centers for Disease Control and
Prevention updated their guidelines on the treatment of
Neisseria gonorrhoeae . The information in this topic is largely
consistent with those guidelines, as well as the 2010 sexually
transmitted disease (STD) treatment guidelines . The clinical
manifestations and diagnosis of gonorrhea are discussed
elsewhere. The treatment of complicated infections, such as