Print friendly version Autoimmune lymphoproliferative syndrome
Other Names for this Disease - Autoimmune lymphoproliferative
syndrome type 1, autosomal dominant - Canale-Smith syndrome -
FAS deficiency See Disclaimer regarding information on this
site. Some links on this page may take you to organizations
outside of the National Institutes of Health. Autoimmune
lymphoproliferative syndrome (ALPS) is a disorder in which the
body cannot properly regulate the number of immune system cells
(lymphocytes). This results in the overproduction of
lymphocytes, which build up and cause enlargement of the lymph
nodes, liver and spleen. Affected individuals can have a variety
of autoimmune disorders, most of which damage the blood cells;
some of the autoimmune disorders associated with ALPS can also
damage the kidneys, liver, eyes, nerves, or connective tissues.
Other signs and symptoms may include skin rashes or
panniculitis; arthritis; inflammation of blood vessels
(vasculitis); mouth sores; premature ovarian failure; a