PGD-FISH possible outcomes No embryo transfer Not all embryos
may be suitable for biopsy. They may however, be suitable for
freezing or transfer. An answer is achieved from over 94% of all
embryos tested. For technical reasons, we may not get an answer
on an individual embryo and the genetic status of that embryo
will be unknown. These embryos may still be suitable for
clinical use. No embryos with desired genetics Embryos tested
and deemed abnormal or affected are unsuitable for transfer.
Hybridization Efficiency: The fluorescent probes need to find
matching regions on each chromosome to stick to. Occasionally,
the probe does not bind selectively to its target or cannot
reach the target to hybridise. This can result in seeing too
many or too few chromosomes in a nucleus. Not every cell in an
embryo may contain the same number of chromosomes – this is
called mosaicism. PGD cannot look at every cell in an embryo.
Therefore, the biopsy piece may not truly represent the rest of
the embryo.