About Site Map Contact Us |A service of the U.S. National
Library of Medicine®| On this page: Reviewed September 2008 What
is the official name of the NLRP12 gene? The official name of
this gene is “NLR family, pyrin domain containing 12.” NLRP12 is
the gene's official symbol. The NLRP12 gene is also known by
other names, listed below. Read more about gene names and
symbols on the About page. What is the normal function of the
NLRP12 gene? The NLRP12 gene provides instructions for making a
protein called monarch-1. Monarch-1 is a member of a family of
proteins called nucleotide-binding domain and leucine-rich
repeat containing (NLR) proteins, which are found in the fluid
inside cells (cytoplasm). Monarch-1 is found mainly in certain
types of white blood cells. NLR proteins are involved in the
immune system, helping to regulate the immune system's response
to injury, toxins, or invasion by microorganisms. Unlike most
NLR proteins that promote increased activity by the immune
system, monarch-1 stops (inhibits)