Medicina (Buenos Aires) versión ISSN 0025-7680 Research
conducted in recent years represents a new dawn of knowledge for
the risk factors of schizophrenia, and genome-wide approaches
have revolutionized the field of genetic mapping of
schizophrenia. The aggregate genetic data increasingly support a
combination of rare and common genetic variation in
schizophrenia, a major role for polygenic inheritance, and a
genetic overlap (pleiotropy) of schizophrenia and other
psychiatric disorders, such as bipolar disorder and autism. A
main challenge for the field is the translation of established
genetic associations into a better pathophysiological
understanding of schizophrenia. The current and upcoming
resequencing programs - both exomes (all exons) and full genomes
- and genome-wide transcriptional analyses will allow a more
thorough dissection of the molecular genetics of the disorder.
Palabras llave : Schizophrenia; Genetics; Genome; Etiology; SNP;
CNV; Polygenic; GWAS; Epidemiology.