Accurate chromosome segregation at each cell division is one of
the most fundamental processes in a living organism. This
complex process requires the coordination of cytoskeletal
components such as microtubules and microtubule motor proteins
that form the mitotic spindle with the replication and
attachment of chromosomes to the segregation apparatus. Both the
high fidelity of chromosome segregation and genome integrity are
essential for normal development and cellular propagation. The
ease of genetic and molecular manipulations to address the
mechanism of chromosome segregation n the context of a live cell
makes the budding yeast an excellent model system to address the
mechanism of spindle assembly and the maintenance of genome
integrity in mitosis. Our lab takes a broad approach to
understanding mitosis in yeast. Recent projects in the lab have
addressed the role of plus end microtubule binding proteins such
as Bim1 and microtubule motor proteins on spindle integrity and
the contribution of pericentric chr