Beckwith-Wiedemann syndrome is a congenital (present from birth)
growth disorder that causes large body size, large organs, and
other symptoms. Causes, incidence, and risk factors: The cause
of Beckwith-Wiedemann syndrome is unknown, but it may be
genetic. Most cases are associated with a defect in chromosome
number 11. Infancy can be a critical period because of low blood
sugar (hypoglycemia ), omphalocele (when present), and an
increased rate of tumor development. Wilm's tumor and adrenal
carcinoma are the most common tumor's in patients with this
syndrome. Signs and tests: The signs of Beckwith-Wiedemann
syndrome include: - A ridge in the forehead caused by premature
closure of the bones (metopic ridge ) - Enlarged fontanelle
(soft spot) - Enlarged kidneys, liver, and spleen - Large size
(90th percentile) - Low blood sugar (hypoglycemia) Tests for
Beckwith-Wiedemann syndrome include: Infants with low blood
sugar may be treated fluids given through a vein ( intravenous
solutions). Defects in the abdominal w