CH391L/S2013 Taylor Pursell Feb 27 2013 |Line 29:||Line 29:|
Revision as of 03:16, 24 February 2013 Identification of Early
Replicating Fragile Sites that Contribute to Genome Instability.
Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT,
Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R,
Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.
Cell. 2013 Jan 22. pii: S0092-8674(13)00008-1. Replication and
Fragile Sites The eukaryotic genome is divide into regions which
are programmed to replicate at different times during S-phase of
the cell cycle. Gene products important to the cell, or active
genes, are replicated in the first half of s-phase, or are
associated with early replication, while inactive genes are
replicated during the second half of S-phase and are associated
with late replication site firing . Chromosomal fragile sites
which are specific stretched of genetic material that are prone
to gaps and breaks following replication leading to chromosome
instability; these frag