Vincristine, Dactinomycin, and Doxorubicin With or Without
Radiation Therapy or Observation Only in Treating Younger
Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I,
Stage II, or Stage III Wilms Tumor What is the purpose of this
trial? RATIONALE: Drugs used in chemotherapy, such as
vincristine, dactinomycin, and doxorubicin, work in different
ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Radiation therapy uses
high-energy x-rays to kill tumor cells. Giving these treatments
after surgery may kill any tumor cells that remain after
surgery. Sometimes, after surgery, the tumor may not need
additional treatment until it progresses. In this case,
observation may be sufficient. PURPOSE: This phase III trial is
studying vincristine, dactinomycin, and doxorubicin with or
without radiation therapy or observation only to see how well
they work in treating patients undergoing surgery for newly
diagnosed stage I, stage II, or stage III Wilms tumor. -