Cancer and Iron - Other groups - Chromatin and Cell Fate - DNA
Bank - Epigenetic Mechanisms of Cancer and Cell Differentiation
- Cancer Genetics and Epigenetics - Computational Biology and
Bioinformatics - Cancer and Iron - ICO-IMPPC Joint Program -
Genetic Diagnostics - Genetic Variation and Cancer - Genomics
and Bioinformatics - Regulatory Genomics - ABO Histo-Blood
Groups and Cancer Iron is an essential micronutrient for both
benign and neoplastic cells. An adequate balance of iron is
critical for health, since iron deficiency leads to anemia, a
major world-wide public health problem, and iron overload
increases the oxidative stress of body tissues leading to
inflammation, cell death, system organ dysfunction, and cancer.
Hereditary Hemochromatosis (HH) is a genetic disorder caused by
excessive iron absorption. This disease is one of the most
common recessive genetic disorders in the Caucasian population
and is mainly due to mutations in the HFE gene. Elevated iron
stores are linked to an increased risk of