No. In about half of the Alagille syndrome cases, the child
inherits the gene mutation from a parent. The other half are
what we call "new mutations," meaning the mutation occurred in
the gene, either when an egg or sperm cell was being made or in
one of the first cells of the developing embryo. While parents
whose children are diagnosed with Alagille syndrome often recall
things that happened during the pregnancy, such as falls or
exposures to chemicals or medications, it's important to
remember that nothing you do can cause or prevent these new
mutations from occurring; they happen as a part of the natural
cell division process. A person who has Alagille syndrome as a
result of a new mutation has a 50 percent chance of passing that
mutation on to his or her offspring. The child who does inherit
a Jagged1 mutation will have some Alagille syndrome
manifestations, but there is no way to predict how severely
affected he or she will be. The severity of Alagille syndrome
varies widely in children with Jagged1 mut