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ensure accuracy. Prudent Practices in the Laboratory: Handling
and Disposal of Chemicals Glove boxes generally operate under
negative pressure, so that any air leakage is into the box. If
the material being used is sufficiently toxic to require the use
of an isolation system, the exhaust air will require special
treatment before release into the regular exhaust system. These
small units have a low airflow; therefore, scrubbing or
adsorption (or both) can be easily accomplished. Some glove
boxes operate under positive pressure. These boxes are commonly
used for experiments for which protection from atmospheric
moisture or oxygen is desired. If positive-pressure glove boxes
are used with highly toxic materials, they should be thoroughly
tested for leaks before each use. Also, a method to monitor the
integrity of the system (such as