Pancrealipase contains the pancreatic enzymes lipase, amylase,
and protease. It is derived from the pancreatic tissues of
swine. These enzymes help digest and absorb fats, proteins, and
carbohydrates. Pancrealipase is used to treat dogs and cats with
exocrine pancreatic insufficiency. Several formulations are
available, including oral capsules, tablets, and delayed-release
capsules and tablets. The powdered forms can be added to food,
and the dosage adjusted to maintain normal feces. Antacids may
diminish the efficacy of pancrealipase, while H2-receptor
antagonists may increase the amount of pancrealipase that
reaches the duodenum. Ursodiol, also known as ursodeoxycholic
acid, is a naturally occurring bile acid. It suppresses hepatic
synthesis and secretion of cholesterol and decreases intestinal
absorption of cholesterol. Reducing cholesterol saturation
allows solubilization of cholesterol-containing gallstones.
Ursodiol also increases bile flow and reduces the hepatotoxic
effect of bile salts by decreasing