- Wolfgang Pernice - Imperial College London - 18 Courtfield
Gardens - SW5 0PD - London, UK - 2nd, BS, Imperial College
London, life sciences I think the major directions we could take
the project into are the following: - Using a micriobial
organism as a bio-detector and/or bio-filter. Several ideas were
already discussed during the first two brain-storming sessions,
with focus on public water-systems or dialysis. The combination
of detection and filtering approaches would allow to build uppon
the results of previous iGEM teams, such as the camebridge 2009
project. For example a water-filter approach could include a
recombinant, bio-film-forming bacterial species which
endocytoses, or otherwise sequesters contaminants in water-
circuits. The accumulation of target molecules in/on the cell
could be used as trigger to induce loss of bio-film attachment
so that the "loaded" cell can be filtered out by a secondary,
mechanical filter. Additionally, the receptor could be linked to
a signalling pathway leading to th