The Lancet, Volume 376, Issue 9741 , Pages 568 - 570, 21 August
2010 doi:10.1016/S0140-6736(10)60896-3Cite or Link Using DOI
This article can be found in the following collection: Public
Health Rotavirus: realising the potential of a promising vaccine
In 2006, two studies that described the efficacy and safety of
two new oral rotavirus vaccines were joint winners of The
Lancet's Paper of the Year. 1—3 These trials had been done in
infants in high-income and middle-income countries in the
Americas and Europe, but no efficacy data were available for
infants in low-income populations in Africa and Asia where 85%
of the more than 500 000 deaths from rotavirus occur. 4 Unlike
parenteral vaccines, live oral vaccines have behaved differently
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