- The use of several DNA sequence polymorphisms (normal
variants) that are near or within a gene of interest to track
within a family the inheritance of a disease-causing mutation in
that gene Definition from: GeneReviews from the University of
Washington and the National Center for Biotechnology Information
- A gene-hunting technique that traces patterns of heredity in
large, high-risk families, in an attempt to locate a disease-
causing gene mutation by identifying traits that are co-
inherited with it. Definition from: Office of Rare Diseases at
the National Institutes of Health See also Understanding Medical
Terminology.