Defensin Beta 108B (DEFb118B) , Belongs to the beta-defensin
family. Specifically expressed in testis. Low expression is
detected also in liver.Beta defensins are a family of mammalian
defensins. The beta defensins are antimicrobial peptides
implicated in the resistance of epithelial surfaces to microbial
colonization. Defensins are 2-6 kDa, cationic, microbicidal
peptides active against many Gram-negative and Gram-positive
bacteria, fungi, and enveloped viruses, containing three pairs
of intramolecular disulfide bonds. On the basis of their size
and pattern of disulfide bonding, mammalian defensins are
classified into alpha, beta and theta categories. Every
mammalian species explored thus far has beta-defensins. In cows,
as many as 13 beta-defensins exist in neutrophils. However, in
other species, beta-defensins are more often produced by
epithelial cells lining various organs.