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searches - My saved topics - My newsletter Sequencing by
hybridization Sequencing by Hybridization is a class of methods
for determining the order in which nucleotides occur on a strand
of DNA. Typically used for looking for small changes relative to
a known DNA sequence. The binding of one strand of DNA to its
complementary strand in the DNA double-helix (aka hybridization)
is sensitive to even single-base mismatches when the hybrid
region is short or is specialized mismatch detection proteins
are present. This is exploited in a variety of ways, most
notable via DNA chips or microarrays with thousands to billions
of synthetic oligonucleotides found in a genome of interest plus
many known variations or even all possible single-base
variations. This technology has lar