Researchers have discovered a large - and continually growing -
number of ways to significantly extend healthy and maximum life
span in mice. Here I'll list a selection of twelve of the most
interesting methods I've seen in past years. Note that I'm
omitting a number of studies that show only small (less than
10%) increases in maximum mouse life span, and also leaving out
some work in progress that looks likely to enhance life span.
For example, Cuervo's work on enhancing autophagy where we're
waiting on formal publication of mortality rate data, or
enhanced uncoupling protein studies that show median life span
increases but not maximum life span increases. But on with the
list: 1) Calorie Restriction, Intermittent Fasting, and
Methionine Restriction Imposition of calorie restriction in mice
has been shown to extend life span by around 40% even when
initiated comparatively late in life. See for example, the study
that is the present rejuvenation Mprize winner: Here we
demonstrate that CR initiated in 19-month