|Classification and external resources| Clinical appearance of
Crouzon Syndrome. Crouzon syndrome is a genetic disorder known
as a branchial arch syndrome. Specifically, this syndrome
affects the first branchial (or pharyngeal) arch, which is the
precursor of the maxilla and mandible. Since the branchial
arches are important developmental features in a growing embryo,
disturbances in their development create lasting and widespread
effects. This syndrome is named after Octave Crouzon, a French
physician who first described this disorder. He noted the
affected patients were a mother and her daughter, implying a
genetic basis. First called "craniofacial dysostosis", the
disorder was characterized by a number of clinical features.
This syndrome is caused by a mutation in the fibroblast growth
factor receptor II, located on chromosome 10. Now known as
Crouzon syndrome, the disease can be described by the
rudimentary meanings of its former name. What occurs in the
disease is that an infant's skull and facial bones,