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permission - MicroRNA Regulation of NAC-Domain Targets Is
Required for Proper Formation and Separation of Adjacen...
Current Biology, Volume 14, Issue 12, 22 June 2004, Pages
1035-1046 Allison C Mallory, Diana V Dugas, David P Bartel and
Bonnie Bartel SummaryBackground: MicroRNAs (miRNAs) are ∼21
nucleotide (nt) RNAs that regulate gene expression in plants and
animals. Most known plant miRNAs target transcription factors
that influence cell fate determination, and biological functions
of miRNA-directed regulation have been reported for four of 15
known microRNA gene families: miR172, miR159, miR165, and
miR168. Here, we identify a developmental role for
miR164-directed regulation of NAC-domain genes, which encode a
family of transcription factors that includes CUP-SHAPED
COTYLEDON1 (CUC1) and CUC2.Results: Expression of a
miR164-resistant version of CUC1 mRNA from the CUC1 promoter
causes alte