Cystic Fibrosis and the Digestive System Children with CF have
an abnormality in the function of a cell protein called the
cystic fibrosis transmembrane regulator (CFTR). CFTR controls
the flow of water and certain salts in and out of the body's
cells. As the movement of salt and water in and out of cells is
altered, mucus becomes thickened. In the digestive system, CF
mainly affects the pancreas. The pancreas is an organ that
secretes substances which aid in digestion and control the
levels of blood sugar. As a result of the abnormality in the
function of the cystic fibrosis transmembrane regulator (CFTR),
the secretions from the pancreas become thick and lead to an
obstruction of the ducts. This obstruction then causes a
decrease in the secretion of digestive enzymes from the
pancreas. A child with CF has difficulty absorbing fats, some
proteins, and fat-soluble vitamins A, D, E, and K. The problems
with the pancreas can become so severe that some of the hormone
cells in the pancreas can be destroyed. This