|Citation||Rui, Y., Bai, J., Perrimon, N. (2010). Sarcomere
formation occurs by the assembly of multiple latent protein
complexes. PLoS Genet. 6(11): e1001208. (Export to RIS)|
|Publication Type||Research paper| |PubMed Abstract||The
stereotyped striation of myofibrils is a conserved feature of
muscle organization that is critical to its function. Although
most components that constitute the basic myofibrils are well-
characterized biochemically and are conserved across the animal
kingdom, the mechanisms leading to the precise assembly of
sarcomeres, the basic units of myofibrils, are poorly
understood. To gain insights into this process, we investigated
the functional relationships of sarcomeric protein complexes.
Specifically, we systematically analyzed, using either RNAi in
primary muscle cells or available genetic mutations, the
organization of myofibrils in Drosophila muscles that lack one
or more sarcomeric proteins. Our study reveals that the thin and
thick filaments are mutually dependent on each other