Experimental AD4-H5-VTN Vaccine in Healthy Volunteers -
Adenoviruses typically cause cold or pink eye symptoms. These
viruses may be used in vaccines to help stimulate an immune
system response. Researchers want to test an adenovirus vaccine
called the AD4-H5-VTN to see if it produces a strong enough
immune response. AD4-H5-VTN may then be used as part of vaccines
to prevent diseases such as malaria or HIV. However, because the
vaccine may cause cold symptoms, the people who receive the
vaccine and members of their household must take part in the
study. - To test the safety and effectiveness of the AD4-H5-VTN
vaccine. - Healthy volunteers between 18 and 45 years of age. -
Household members or intimate contacts of the volunteers between
18 and 65 years of age. People in households with young children
or persons with immune system problems will not be allowed on
this study. - Participants will be screened with a physical exam
and medical history. They will have blood and urine tests. They
will also answer quest