Chromosome 8, Monosomy 8p is a rare chromosomal disorder
characterized by deletion (monosomy) of a portion of the eighth
chromosome. Associated symptoms and findings may vary greatly in
range and severity from case to case. However, common features
include growth deficiency; mental retardation; malformations of
the skull and facial (craniofacial) region, such as a small head
(microcephaly) and vertical skin folds that may cover the eyes'
inner corners (epicanthal folds); heart (cardiac) abnormalities;
and/or genital defects in affected males. Additional
craniofacial features may also be present that tend to become
less apparent with age, such as a short, broad nose; a low, wide
nasal bridge; and/or a small jaw (micrognathia). In most cases,
Chromosome 8, Monosomy 8p appears to result from spontaneous (de
novo) errors very early in embryonic development that occur for
unknown reasons.