A 23-year-old Asian male presented with edema, new-onset
hypertension, hematuria, and proteinuria. He reported a sore
throat 8 days prior. There was no history of hypertension or
diabetes mellitus. Physical examination revealed BP 168/100, 1+
lower extremity edema, and no rash. Lab tests revealed a serum
creatinine of 1.9 mg/dL, 24hr urine protein 2.5 g/day, positive
ASLO, microhematuria, negative ANA, depressed C3, normal C4,
negative HBsAg & HCV Ab, hct 36%, and serum albumin 3 g/dL. SPEP
and UPEP showed no evidence of a monoclonal spike. Kidneys
measured 12.6 & 12.4 cm in length by ultrasound. RENAL BIOPSY
FINDINGS: Acute post-infectious glomerulonephritis. Acute post-
infectious glomerulonephritis (APIGN) is an immune complex-
mediated glomerular disease which classically follows group A
streptococcal infection of the upper respiratory tract or skin
in children, but may also occur after other bacterial
infections, in both children and adults. Childhood APIGN
typically presents with nephritic syndrome, hypoc