Introns in promoterhow is it possible? Posted 15 May 2012 -
09:38 PM Posted 09 June 2012 - 08:21 AM Posted 09 August 2012 -
01:53 AM Eukaryotes promoters are quite complex and some binding
sites for proteins that activate the transcription may actually
be downstream of the mRNA start position, or it may be that the
presensce of the first intron/exon increases the promoters
activity and is therefore considered part of the promoter
region. Many of the strongest mammalian promoters have introns
in them, Ubiquitin, Elongation factor alpha and chicken beta
actin (full length) all have introns in them. In fact, many
people add an intron upstream of their gene to prolong
expression in vivo. It makes a gene more like a natural gene and
decreases its chances of being methylated.