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Library of Medicine®| Mitochondrial neurogastrointestinal
encephalopathy disease (often shortened to MNGIE disease) On
this page: Reviewed June 2008 What is MNGIE disease?
Mitochondrial neurogastrointestinal encephalopathy (MNGIE)
disease is a condition that affects several parts of the body,
particularly the digestive system and nervous system. The major
features of MNGIE disease can appear anytime from infancy to
adulthood, but signs and symptoms most often begin by age 20.
The medical problems associated with this disorder worsen with
time. Abnormalities of the digestive system are among the most
common and severe features of MNGIE disease. Almost all affected
people have a condition known as gastrointestinal dysmotility,
in which the muscles and nerves of the digestive system do not
move food through the digestive tract efficiently. The resulting
digestive problems include feelings of fullness (satiety) after
eating only a small amount, trouble swa