Philip D'Arcy Hart Philip Montagu D’Arcy Hart, CBE, (25 June
1900 – 30 July 2006) was a British medical researcher and
pioneer in tuberculosis treatment. Grandson of Samuel Montagu,
1st Baron Swaythling, he became a consultant physician at
University College Hospital at the age of 34. Three years later,
he joined the Medical Research Council (MRC), and became
involved with much of the MRC's early research into dust
diseases in coal miners. He was a member of the MRC Streptomycin
in Tuberculosis Trials Committee; their study evaluating the use
of streptomycin in treating tuberculosis is generally accepted
as the first randomized clinical trial. At the age of 71, Hart
published a seminal paper in the Journal of Experimental
Medicine, showing the intracellular pathogen Mycobacterium
tuberculosis avoids destruction in the cell's lysosomes by
circumventing these organelles altogether—a trick now known to
be used by many other intracellular pathogens. In 1941, Hart
married Ruth Meyer, later a medical gynaecologist.