Published in Gene Therapy Weekly, November 2nd, 2006 Study 1:
According to recent research from the United States, adenoviral
p53 gene therapy is promising for cancer. "Mutations in the p53
gene are the most frequent genetic alterations in human tumours,
occurring in approximately 50% of all cancers. The p53 protein
is pivotal in maintaining genetic integrity after DNA damage,
and alterations in the p53 pathway, including mutations in the
p53 gene, greatly increase the probability of tumor formation,"
wrote D.I. Gabrilovich and colleagues, University of Southern
Florida. "Gene therapy using adenoviral p53 has emerged... Want
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