Proteinase 3 (PR3) is a serine protease and antibodies to PR3
are termed PR3-ANCA. Approximately 80-90% of patients with
Wegener’s granulomatosis manifest PR3-ANCA. PR3-ANCA also occurs
in other systemic vasculitides, e.g. microscopic polyangiitis
and focal and extracapillary necrotizing glomerulonephritis. As
the clinical spectrum of ANCA‑related diseases increases and
further target antigens are identified and characterised,
antigen-specific ELISAs using highly purified antigen extracts
may play a valuable role in the identification of disease sub-
types. The Wieslab® PR3-ANCA test kit is an enzyme-linked
immunosorbent assay (ELISA) for detection and quantitation of
IgG antibodies to proteinase 3 (PR3) in human sera. The assay is
used to detect antibodies in a single serum specimen. The
results of the assay are to be used as an aid to the diagnosis
of granulomatosis with polyangiitis (Wegener’s granulomatosis).
The analysis should be performed by trained laboratory
professionals. FOR IN VITRO DIAGNOSTIC USE.