CDC Perinatal Hepatitis B Virus Infection Case Definition
Perinatal hepatitis B in the newborn may range from asymptomatic
to fulminant hepatitis. HBsAg positivity in any infant aged
>1–24 months who was born in the United States or in US
territories to an HBsAg-positive mother Comment: Infants born to
HBsAg-positive mothers should receive hepatitis B immune
globulin (HBIG) and the first dose of hepatitis B vaccine within
12 hours of birth, followed by the second and third doses of
vaccine at 1 and 6 months of age, respectively. Postvaccination
testing for HBsAg and anti-HBs (antibody to HBsAg) is
recommended from 3 to 6 months following completion of the
vaccine series. If HBIG and the initial dose of vaccine are
delayed for >1 month after birth, testing for HBsAg may
determine if the infant is already infected. Abbreviations: CDC,
Centers for Disease Control and Prevention; HBsAg, hepatitis B
surface antigen; anti-HBs, antibody to HBsAg; HBIG, hepatitis B
immune globulin. SOURCE: CDC, 2009a.