Toxicosis potential is usually determined more by the multitude
of related factors than by actual toxicity of the toxicant.
Exposure-related, biologic, or chemical factors regulate
absorption, metabolism, and elimination, and thus, influence
observed clinical consequences. Factors Related to Exposure Dose
is the primary concern; however, the exact intake of toxicant is
seldom known. Duration and frequency of exposure are important.
The route of exposure affects absorption, translocation, and
perhaps metabolic pathways. Exposure of a toxicant relative to
periods of stress or food intake may also be a factor. Following
ingestion of some toxicants, emesis may occur if the stomach is
empty, but if partly filled, the toxicant is retained and
toxicosis can occur. Environmental factors, such as temperature,
humidity, and barometric pressure, affect rates of consumption
and even the occurrence of some toxic agents. Many mycotoxins
and poisonous plants are correlated with seasonal or climatic
changes. For example, the