A Kansas State University research team has resolved a 40-year-
old debate on the role of iron acquisition in bacterial invasion
of animal tissues. The collaborative research—led by Phillip
Klebba, professor and head of the department of
biochemistry—clarifies how microorganisms colonize animal hosts
and how scientists may block them from doing so. The findings
suggest new approaches against bacterial disease and new
strategies for antibiotic development. The study—in
collaboration with Tyrrell Conway, director of the Microarray
and Bioinformatics Core Facilities at the University of
Oklahoma, and Salete M. Newton, Kansas State University research
professor of biochemistry—recently appeared in PLOS ONE. It
shows how iron acquisition affects the ability of bacteria to
colonize animals, which is the first stage of microbial disease.
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