New triple negative breast cancer research recently published in
the journal Cell appears to have identified a tumor suppressor
gene involved in TNBC development and progression. In this new
study, breast cancer researchers used a genetic screening
process to examine gene changes in triple negative breast cancer
cells. The investigators identified the gene PTPN12 as potent
tumor suppressor gene that appears to be linked to TNBC. The
researchers reported: - The PTPN12 gene powerfully inhibits the
growth of breast cells and their transformation into cancer
cells. - PTPN12 functions by blocking the action of multiple
growth factor enzymes involved in breast cancer development and
progression. - The PTPN12 gene is frequently inactivated in
triple negative breast cancer cells, thereby preventing it from
blocking tumor suppression. - Restoration of PTPN12
functionality inhibits the metastatic potential of TNBC cells. -
The tumorigenic and metastatic ability of TNBC cells can also be
inhibited by blocking the growth