Growth Hormone and Endothelial Function in Children Objective:
This study is designed to determine whether growth hormone
treatment in children 8 to 18 years of age alters function of
the lining of the arteries. This may play a role in increasing
or decreasing the risk of heart disease. Methods. Twenty
children, for whom growth hormone therapy will be otherwise
provided, will be studied before and 3 months after starting
growth hormone. Subjects can be on other hormonal replacements
but no other medications. Each study will be done in the fasting
state. The blood vessel function will be determined by measuring
the change in forearm blood flow before and after blocking flow
to the arm for 5 minutes. Blood will be drawn after the test to
measure glucose, insulin and fats. Growth Hormone Deficiency
Drug: growth hormone |Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety Study Intervention Model: Single
Group Assignment Masking: Open Label Primary Purpose: Treatment
|Official Title:||Growth