|Met proto-oncogene (hepatocyte growth factor receptor)|
Crystallographic structure of MET. PDB rendering based on 1r0p.
|External IDs||ChEMBL: GeneCards:| |RNA expression pattern|
c-Met (MET or MNNG HOS Transforming gene) is a proto-oncogene
that encodes a protein known as hepatocyte growth factor
receptor (HGFR). The hepatocyte growth factor receptor protein
possesses tyrosine-kinase activity. The primary single chain
precursor protein is post-translationally cleaved to produce the
alpha and beta subunits, which are disulfide linked to form the
mature receptor. MET is a membrane receptor that is essential
for embryonic development and wound healing. Hepatocyte growth
factor (HGF) is the only known ligand of the MET receptor. MET
is normally expressed by cells of epithelial origin, while
expression of HGF is restricted to cells of mesenchymal origin.
Upon HGF stimulation, MET induces several biological responses
that collectively give rise to a program known as invasive
growth. Abnormal MET activation in can