A receptor found on blood platelets whose importance as a
potential pharmaceutical target has long been questioned may in
fact be fruitful in drug testing, according to new research from
Michigan State University chemists. A team led by Dana Spence of
MSU's Department of Chemistry has revealed a way to isolate and
test the receptor known as P2X1. By creating a new, simple
method to study it after blood is drawn, the team has unlocked a
potential new drug target for many diseases that impact red
blood cells, such as diabetes, hypertension and cystic fibrosis.
Researchers can evaluate the receptor not only in developing new
drugs but also re-testing existing medications that could work
now by attaching to the receptor. "Scientists are always looking
for new 'druggable' receptors in the human body," Spence said.
"This receptor, P2X1, has long been viewed as not important in
platelets; our studies show that is not necessarily true. The
receptor is very active; you just need to be careful in working
with it." The