Dermagraft is a US Food and Drug Administration (FDA) approved
skin substitute that helps heal diabetic foot ulcers. These
ulcers are serious wounds that occur most often in the skin over
the ball of the foot or on the bottom of the big toe. Helping to
Grow New Skin Dermagraft is a dissolvable mesh material that
contains human connective tissue cells called fibroblasts.
Dermagraft is placed directly on the ulcer, where the mesh and
fibroblasts are gradually absorbed. Fibroblasts produce many of
the same factors found in healthy skin. As the fibroblasts
attach and grow in the wound, they help replace and rebuild the
damaged parts in the foot. Dermagraft can be used on the
following types of ulcers: - Full-thickness diabetic foot ulcers
that have been present for longer than six weeks - Ulcers that
extend deeper into the skin where the blood vessels are, but do
not involve tendon, muscle, joint capsule, or bone When Not to
Use Dermagraft There are certain cases when Dermagraft should
not be used, such as: - Inf