Aniridia is an eye disorder characterized by a complete or
partial absence of the colored part of the eye (the iris). These
iris abnormalities may cause the pupils to be abnormal or
misshapen. Aniridia can cause reduction in the sharpness of
vision (visual acuity) and increased sensitivity to light
(photophobia). Aniridia may occur either as an isolated eye
abnormality or as part of the Wilms tumor-aniridia-genital
anomalies-retardation (WAGR) syndrome.People with aniridia can
also have other eye problems including increased pressure in the
eye (glaucoma), clouding of the lens of the eye (cataracts), or
underdevelopment of the structures that carry information from
the eyes to the brain (optic nerves). Individuals with aniridia
may also have involuntary eye movements (nystagmus) or
underdevelopment of the region at the back of the eye
responsible for sharp central vision (foveal hypoplasia). Many
of these eye problems contribute to progressive vision loss in
affected individuals. The severity of symptoms is t