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permission - Mixed-species malaria infections in humans Trends
in Parasitology, Volume 20, Issue 5, 1 May 2004, Pages 233-240
Mayfong Mayxay, Sasithon Pukrittayakamee, Paul N Newton and
Nicholas J White AbstractMixed-species malaria infections are
often not recognized or underestimated. In Asia, surveys usually
report that <2% of infections are mixed, whereas therapeutic
studies in vivax or falciparum malaria have demonstrated a high
prevalence (up to 30%) of infection with the other malaria
species during convalescence, suggesting covert co-infection. In
epidemiological studies, a high prevalence of cryptic mixed-
malaria species infection has been detected by sensitive PCR
techniques. Concurrently infecting malaria species are mutually
suppressive with Plasmodium falciparum tending to dominate
Plasmodium vivax, but P. vivax attenuating the severity of P.
falciparum. There is evidence for some