On the suggestion that the gonococcus was one of the organisms
susceptible to sulfanilamide, it was decided to treat gonorrheal
vaginitis in children by oral administration of sulfanilamide in
further search for a simple and effective method of handling
this therapeutic problem. After encouraging results had been
obtained in cases of vaginitis, sulfanilamide was applied to the
treatment of gonorrheal urethritis in boys and of gonorrheal
conjunctivitis. This report summarizes the results of treatment
with sulfanilamide in 9 cases of conjunctivitis, in 5 cases of
urethritis in boys and in 22 cases of vaginitis in girls since
May 1937. Diagnosis of gonococcic infection was made on the
basis of the finding of gram-negative intracellular diplococci,
morphologically typical of gonococci, in smears from the eyes,
urethra or vagina. Gonococcic complement fixation tests made on
admission were positive in about two thirds of the patients.
Cultures for gonococci were not available to