About Site Map Contact Us |A service of the U.S. National
Library of Medicine®| On this page: Reviewed April 2013 What is
the official name of the LRP2 gene? The official name of this
gene is “low density lipoprotein receptor-related protein 2.”
LRP2 is the gene's official symbol. The LRP2 gene is also known
by other names, listed below. Read more about gene names and
symbols on the About page. What is the normal function of the
LRP2 gene? The LRP2 gene provides instructions for making a
protein called megalin, which functions as a receptor. Receptor
proteins have specific sites into which certain other proteins,
called ligands, fit like keys into locks. Together, ligands and
their receptors trigger signals that affect cell development and
function. Megalin has many ligands involved in various body
processes, including the absorption of vitamins A and D, immune
functioning, stress response, and the transport of fats in the
bloodstream. Megalin is embedded in the membrane of cells that
line the surfaces and ca