Spectralis HRA+OCT Imaging of the Retina With Autofluorescence
in Sickle Cell Disease To determine the retinal and choroidal
thickness in patients with sickle cell disease compared to age,
race matched population without sickle cell disease to allow a
better understanding of the clinical manifestations of sickle
cell retinopathy. The purpose of this research study is to
evaluate the relationship between sickle cell disease and the
eye. The research study is recruiting African American
population with or without Sickle Cell Disease. The investigator
in charge of this study is Dr E. Bowie. Approximately 60
subjects of both sexes will be enrolled at the Medical
University of South Carolina. About 10% of African Americans
have an abnormal hemoglobin gene. About 8% of African Americans
are heterozygous for Hb S. In the United States, sickle cell
anemia primarily occurs in the black population, with
approximately 0.2% of African American children afflicted by
this disease. The prevalence in adults is lower because