Trimethylglycine (TMG), also called betaine, is a substance
manufactured by the body. It helps break down another naturally
occurring substance called homocysteine. In certain rare genetic
conditions, the body cannot dispose of homocysteine, resulting
in its accumulation to extremely high levels. This, in turn,
leads to accelerated cardiovascular disease and other problems.
Oral TMG is an FDA-approved treatment for this condition. It
"methylates" homocysteine, removing it from circulation.
Meaningful, but not altogether consistent, evidence suggests
that the relatively slight elevation of homocysteine that can
occur in healthy people is also harmful.6 On this basis, it has
been suggested that TMG might reduce heart disease risk in
healthy people as well. However, this has not been proven, and
TMG has shown the potential for having adverse effects on
cholesterol profile, which could counter any possible benefit
via homocysteine. Note: TMG is similar chemically to betaine
hydrochloride, but it has entirely diff