Doxsey S, et al. (2005) Centrosomes in cellular regulation. Annu
Rev Cell Dev Biol 21():411-34 Abstract: Centrosomes, spindle
pole bodies, and related structures in other organisms are a
morphologically diverse group of organelles that share a common
ability to nucleate and organize microtubules and are thus
referred to as microtubule organizing centers or MTOCs. Features
associated with MTOCs include organization of mitotic spindles,
formation of primary cilia, progression through cytokinesis, and
self-duplication once per cell cycle. Centrosomes bind more than
100 regulatory proteins, whose identities suggest roles in a
multitude of cellular functions. In fact, recent work has shown
that MTOCs are required for several regulatory functions
including cell cycle transitions, cellular responses to stress,
and organization of signal transduction pathways. These new
liaisons between MTOCs and cellular regulation are the focus of
this review. Elucidation of these and other previously
unappreciated centrosome funct