CGRP stands for Calcitonin Gene-Related Peptide. It is a
calcitonin group compound made up of polymers of amino acid
monomers. CGRP is manufactured in the human body in the nerve
cells (neurons) of the central nervous system and the peripheral
nervous system. Research – New Migraine drugs In The Pipeline
(1) So what is the function of CGRP? Of the many functions, CGRP
is a powerful vasodilator and it contributes significantly in
the transmission of pain message through the body. It is also
believed to play a critical role in cardiovascular homeostasis
as well as in processing noxious stimuli that has the potential
to damage the tissues of the heart. The development of drugs
which are essentially CGRP receptor antagonist is in the
pipeline aimed at helping migraineurs the world over cull the
pain of their migraine episodes. How does the CGRP receptor
antagonist do this? It has been observed that during the onset
of a migraine attack, CGRP binds to CGRP receptors and activates
these receptors which then transmi