An international team of scientists has discovered a novel
genetic trait that protects its carriers against the deadliest
forms of malaria, while people without the trait are more likely
to succumb to its fatal consequences. This trait — a mutation or
“polymorphism” in the NOS2 gene — controls the production of
nitric oxide, a small chemical that can kill parasites and
prevent malaria disease. From Duke University:Genetic Variant
Protects People Against Malaria DURHAM, N.C. — An international
team of scientists has discovered a novel genetic trait that
protects its carriers against the deadliest forms of malaria,
while people without the trait are more likely to succumb to its
fatal consequences. This trait — a mutation or “polymorphism” in
the NOS2 gene — controls the production of nitric oxide, a small
chemical that can kill parasites and prevent malaria disease.
Results of their study are published in the Nov. 9, 2002, issue
of The Lancet. The genetic variant explains why some people with
malaria have only