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ensure accuracy. The Children's Vaccine Initiative: Achieving
the Vision successive steps of development. This chapter
describes the various phases of vaccine development and a number
of obstacles that can arise in this process. These barriers can
discourage initial investment or prevent the vaccine from
advancing beyond a certain stage. At every step, commercial
manufacturers weigh the likelihood of product success against
its market potential. The decision-making process for the
development and production of vaccines should be guided by an
assessment of critical public health needs. Priorities should be
established and the desired vaccine characteristics should be
defined. In this way, the vast resources of the U.S. and
international public and private sectors can be directed to a
set of common and complementary goals. There ha