Interviewee: Frederick Sanger. Frederick Sanger talks about the
differences between sequencing proteins and sequencing DNA.
(DNAi Location: Manipulation > Techniques > Sorting and
sequencing > Interviews > Sequencing proteins and DNA) You know,
at first we tried to use the methods we'd used for proteins and
to some extent these worked. But it was, turned out to be a very
different problem because the proteins have twenty components,
twenty amino acids, and all different. Whereas the nucleic acids
just have the four components, the mononucleotides, and you have
to work out sequencing on that. And the methods used for
proteins were not generally applicable. For instance they were,
the amino acids were all very different chemically, so you could
work out methods for separating them. Whereas the nucleic acids
only had the four components, which were rather similar and so
you knew, had to use quite different methods. sanger dna
sequencing,sanger sequencing,frederick sanger,manipulation
techniques,nucleic acids,ami