Autosomal recessive hyper IgE syndrome Other Names for this
Disease - AR hyperimmunoglobulin E syndrome - DOCK8 deficiency -
HIES autosomal recessive - Hyper Ig E syndrome, autosomal
recessive In contrast to AD-HIES, the AR variant is further
characterized by extreme hypereosinophilia (increase in the
eosinophil count in the bloodstream); susceptibility to viral
infections such as Herpes simplex and Molluscum contagiosum;
involvement of the central nervous system; T-cell defects; and a
high death rate. The dental, skeletal, connective tissue, and
facial features present in AD-HIES are absent in AR-HIES. AR-
HIES is inherited in an autosomal recessive fashion and is
caused by mutations in the DOCK8 gene. - Woellner C & Grimbacher
B. Autosomal recessive hyper IgE syndrome. Orphanet.
http://www.orpha.net/consor/cgi-
bin/OC_Exp.php?lng=EN&Expert=169446. Accessed June 2, 2011. -
Hyper-IgE Recurrent Infection Syndrome, Autosomal Recessive.
Online Mendelian Inheritance of Man (OMIM). Autosomal recessive
hyper IgE synd