Gene Expression and Inflammation in Overweight Subjects This
study will look at gene expression (whether particular sets of
genes are activated ["turned on"] or deactivated ["turned off"])
in overweight people as compared to non-overweight individuals.
It will also investigate the potential role of inflammatory and
protective substances that are produced naturally by the body
within fat tissue. Findings from the study may lead to the
development of ways to predict who will respond best to diet
therapy. Healthy individuals between 25 and 45 years of age may
be eligible for this study. Overweight subjects must have a BMI
of 25 to 40, and non-overweight control subjects a BMI of 19 to
24.9. Candidates are screened with a medical history, physical
examination, blood tests and electrocardiogram (EKG). They are
instructed to record their dietary intake for a 3-day period and
to collect their urine for a 24-hour interval. Participants have
their food records reviewed a week after the screening visit.
They are then s