NIH Research Matters January 28, 2008 Genes Influence Blood
Lipid Levels and Heart Disease Risk Blood levels of lipids like
cholesterol and triglycerides are important risk factors for
coronary artery disease. Scientists know about certain lifestyle
factors—such as smoking, diet and physical activity—that affect
blood lipid levels, but the role of genetics hasn't been well
understood. A large study has now revealed more than 25 genetic
variants in 18 genes connected to blood cholesterol and lipid
levels. The finding may lead to new strategies for treating and
preventing coronary artery disease. Animal studies have revealed
that, when long-term memories are recalled, they become fragile
and changeable. New proteins must be produced to reconsolidate
retrieved memories and return them to long-term storage in the
brain. Recalling a memory, then, opens a window of opportunity
for that memory to be changed—what researchers call a
"reconsolidation window." Earlier studies showed that certain
drugs can block reconsol