Dorsett D (2007) Roles of the sister chromatid cohesion
apparatus in gene expression, development, and human syndromes.
Chromosoma 116(1):1-13 Abstract: The sister chromatid cohesion
apparatus mediates physical pairing of duplicated chromosomes.
This pairing is essential for appropriate distribution of
chromosomes into the daughter cells upon cell division. Recent
evidence shows that the cohesion apparatus, which is a
significant structural component of chromosomes during
interphase, also affects gene expression and development. The
Cornelia de Lange (CdLS) and Roberts/SC phocomelia (RBS/SC)
genetic syndromes in humans are caused by mutations affecting
components of the cohesion apparatus. Studies in Drosophila
suggest that effects on gene expression are most likely
responsible for developmental alterations in CdLS. Effects on
chromatid cohesion are apparent in RBS/SC syndrome, but data
from yeast and Drosophila point to the likelihood that changes
in expression of genes located in heterochromatin could contr