Role of p53 Gene in Metabolism Regulation in Patients With Li-
Fraumeni Syndrome This study will examine metabolic and
biological factors in people with Li-Fraumeni syndrome, a rare
hereditary disorder that greatly increases a person's
susceptibility to cancer. Patients have a mutation in the p53
tumor suppressor gene, which normally helps control cell growth.
This gene may control metabolism as well as cancer
susceptibility, and the study findings may help improve our
understanding of not only cancer but also other conditions, such
as cardiovascular function. Healthy normal volunteers and
patients with the Li-Fraumeni syndrome and their family members
may be eligible for this study. Candidates must be at least 18
years of age, in overall good health and cancer-free within 1
year of entering the study. Participants undergo the following
procedures: " Blood tests for routine lab values and for
research purposes. " ECG and echocardiogram (heart ultrasound)
to evaluate heart structure and function. " Resting and