Dec. 4, 2012 Selective targeting of the neurotransmitter that
differentially affects brain cells that control the two distinct
functions of the pancreas may allow for new medication therapies
for conditions such as diabetes, dyspepsia and gastro-esophageal
reflux, according to Penn State College of Medicine researchers.
"This study differs from what's been reported previously about
brain neurons that control the gastrointestinal tract," said R.
Alberto Travagli, professor, Department of Neural and Behavioral
Sciences, and lead investigator. "It provides further support to
the idea that separate nerve pathways regulate the diverse
functions of organs along the upper gastrointestinal tract." The
pancreas has two functional parts: one that releases digestive
enzymes, and one that releases hormones like insulin and
glucagon. The vagus nerve, which originates in the brain,
regulates both of these pancreatic functions. This nerve detects
chemical and biological changes that occur along the
gastrointestinal tract an