The Lancet, Volume 357, Issue 9255 , Page 532, 17 February 2001
doi:10.1016/S0140-6736(05)71685-8Cite or Link Using DOI Tying
the genetic sequence to human disease Of the 35 000 genes
sequenced by the human genome project, just 923 are “disease
genes” according to David Valle (Johns Hopkins University School
of Medicine, Baltimore, MA, USA) in his analysis paper ( Nature
2001; 409 : 853—55). Most of these are responsible for rare
single-gene disorders, and as Jaakko Kaprio (University of
Helsinki, Finland) points out, “the complexity of even single-
gene disorders such as cystic fibrosis suggests that the path
from structural knowledge to practical applications ... This
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