Hyperimmunoglobulin E syndrome Hyperimmunoglobulin E syndrome is
a rare, inherited disease that causes problems with the skin,
sinuses, lungs, bones, and teeth. Job syndrome; Hyper IgE
syndrome Hyperimmunoglobulin E syndrome is also called Job
syndrome, after the biblical character Job whose faithfulness
was tested by an affliction with draining skin sores and
pustules. People with this condition have long-term, severe skin
infections. The symptoms are usually present in childhood, but
because the disease is so rare, it often takes years before a
correct diagnosis is made. Recent research suggests that the
disease is often caused by a genetic change (mutation) -- a
change in the STAT3 gene on chromosome 4. How this gene
abnormality causes the symptoms of the disease is not well
understood. However, people with the disease have higher-than-
normal levels of an antibody called IgE. - Bone and tooth
defects, including fractures and losing the baby teeth late -
Skin abscesses and infection - Repeated sinus infecti