Stemming the spread of cancer Okayama University's Masaharu Seno
and colleagues have demonstrated in vitro the development of
cancer stem cells (CSCs) from a type of normal stem cell exposed
to their hypothetical microenvironment of a tumor. Cancer stem
cells (CSCs) have been proposed as an explanation for the spread
of cancer. These cells are tumorigenic and have the capacity of
both self-renewal and differentiation into a range of various
cell types. In this concept, malignant tumors provide
heterogeneous aspects derived from CSCs as well as normal stem
cells provide tissue specific phenotype in response to their
microenvironment. Spheroid GFP.Researchers have now demonstrated
in vitro the development of CSCs from a type of normal stem cell
exposed to their hypothetical microenvironment of a tumor. The
results are the work of a group of scientists led by Masaharu
Seno, a professor of Okayama University, with his collaborators
in China and the US. The researchers cultured mouse induced
pluripotent stem (miPS