THE NATIONAL ACADEMIES PRESS 500 Fifth Street, N.W. Washington,
DC 20001 NOTICE: The project that is the subject of this report
was approved by the Governing Board of the National Research
Council, whose members are drawn from the councils of the
National Academy of Sciences, the National Academy of
Engineering, and the Institute of Medicine. Support for this
project was provided by the American Diabetes Association;
American Society for Microbiology; Amgen, Inc.; Association of
American Medical Colleges; AstraZeneca Pharmaceuticals; Blue
Cross Blue Shield Association; Burroughs Wellcome Fund;
Department of Health and Human Services (Contract Nos.
N01-OD-4-2139 and 223-01-2460); Doris Duke Charitable
Foundation; Eli Lilly and Company; Entelos, Inc.; Genentech;
GlaxoSmithKline; March of Dimes Foundation; Merck & Co.; Pfizer
Inc.; and UnitedHealth Group. Any opinions, findings,
conclusions, or recommendations expressed in this publication
are those of the authors and do not necessarily reflect the view
of the o