Genetic determinants of the immune response to malaria (CP2)
This consortial project seeks to discover human genetic factors
that influence the antibody response to malaria parasite
antigens, focusing particularly on antigens that are under
strong consideration for vaccine development. Each partner study
has conducted epidemiological surveys that attempt to correlate
levels of infection and clinical illness with measurements of
the immune response to malaria. The partner studies differ in
their epidemiological study design and in the precise variables
that are measured, but what all have in common is that they have
provided samples of serum and DNA to a central repository. This
allows all partner studies to share genetic data and anti-
malarial antibody measurements made in a reference laboratory
using a common set of laboratory protocols. - Burkina Faso: The
Centre National de Recherche et de Formation sur le Paludisme
are completing longitudinal and cross-sectional surveys in 4
villages. Study>> - Kenya: The