Example: Drug Metabolism and SNPs in CYP2C9 CYP2C9 genetic
variants are a good example of how SNPs can be linked to
abnormal drug metabolism. CYP2C9 is an important cytochrome P450
protein that works in the liver to metabolize drugs. Genetic
variation in the gene for this protein can alter this
metabolism. As many as 40 percent of persons carry a SNP that
produces a deficient CYP2C9 protein. Deficiencies in this
protein can impair the metabolism of as many as 1 in 5
medications currently on the market. Fortunately, technology
makes it possible for a person to discover the drug metabolism
variants that he or she carries. This information can then
inform drug selection.