Chu S, et al. (1998) The transcriptional program of sporulation
in budding yeast. Science 282(5389):699-705 Abstract: Diploid
cells of budding yeast produce haploid cells through the
developmental program of sporulation, which consists of meiosis
and spore morphogenesis. DNA microarrays containing nearly every
yeast gene were used to assay changes in gene expression during
sporulation. At least seven distinct temporal patterns of
induction were observed. The transcription factor Ndt80 appeared
to be important for induction of a large group of genes at the
end of meiotic prophase. Consensus sequences known or proposed
to be responsible for temporal regulation could be identified
solely from analysis of sequences of coordinately expressed
genes. The temporal expression pattern provided clues to
potential functions of hundreds of previously uncharacterized
genes, some of which have vertebrate homologs that may function
during gametogenesis. |Status: Published||Type: Journal
Article||PubMed ID: 9784122| Topics ad