|Retinal Pigment Epithelium (RPE) Detachment Signs and Symptoms
In most instances, serous detachment of the RPE occurs
asymptomatically. Only in those cases in which the macula is
affected will patients report blurred vision, metamorphopsia,
micropsia, or positive scotomas. Other associated clinical
findings may include induced hyperopia and delayed retinal
recovery time on the photostress test. Most individuals with RPE
detachment are male, between the ages of 20 and 60 years. The
history often reveals predisposing or concurrent ocular
conditions such as macular degeneration, idiopathic central
serous chorioretinopathy (ICSC), angioid streaks, presumed
ocular histoplasmosis syndrome (POHS), or hereditary choroidal
degeneration. In other cases, the condition occurs
idiopathically. RPE detachment appears ophthalmoscopically as
single or multiple, well-circumscribed round or oval lesions
within the posterior fundus. The lesions are typically dome-
shaped with slight elevation and appear yellow to orange in
color