The notion of transplanting adult stem cells to treat or even
cure age-related macular degeneration has taken a significant
step toward becoming a reality. In a study published today in
Stem Cells, Georgetown University Medical Center researchers
have demonstrated, for the first time, the ability to create
retinal cells derived from human-induced pluripotent stem cells
that mimic the eye cells that die and cause loss of sight. Age-
related macular degeneration (AMD) is a leading cause of visual
impairment and blindness in older Americans and worldwide. AMD
gradually destroys sharp, central vision needed for seeing
objects clearly and for common daily tasks such as reading and
driving. AMD progresses with death of retinal pigment epithelium
(RPE), a dark color layer of cells which nourishes the visual
cells in the retina. While some treatments can help slow its
progression, there is no cure. The discovery of human induced
pluripotent stem (hiPS) cells has opened a new avenue for the
treatment of degenerative di