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| |style="background: #F8EABA; text-align: center;"
colspan="2"||Bradykinin| |style="background: #F8EABA; text-
align: center;" colspan="2"|| Except where noted otherwise, data
are given for| materials in their standard state (at 25 °C, 100
kPa) Infobox disclaimer and references In humans, bradykinin is
broken down by three kininases: angiotensin-converting enzyme
(ACE), aminopeptidase P (APP), and carboxypeptidase N (CPN),
which cleave the 7-8, 1-2, and 8-9 positions, respectively .
Bradykinin is a potent endothelium-dependent vasodilator, causes
contraction of non-vascular smooth muscle, increases vascular
permeability and also is involved in the mechanism of pain. In
some aspects, it has similar actions to that of histamine, and
like histamine is released from venules rather than arterioles.
Bradykinin is also thought to be the cause of the dry cough in
some patients on angiotensin con