Contact: Michael Mullaney Rensselaer Polytechnic Institute
Caption: A new study from Rensselaer Polytechnic Institute
shows, for the first time, how the little-understood protein
osteocalcin plays a significant role in the strength of our
bones. A healthy bone is seen on the left. In the case of a
slip, trip, or fall, the force of the impact on a bone
physically deforms a pair of joined proteins, osteopontin and
osteocalcin, and results in the formation of nanoscale holes
within the bone’s mineral structure, as seen in the middle.
These holes, called dilatational bands, function as a natural
defense mechanism, and help to prevent further damage to the
surrounding bone. However, if the force of the impact is too
great--or if the bone is lacking osteopontin, osteocalcin, or
both--the bone will crack and fracture, as seen on the right.
Findings of the study could lead to new strategies and
therapeutics for fighting osteoporosis and lowering the risk of
bone fracture. Usage Restrictions: Please include image cred