|CMT causes degeneration of the peripheral nerves, leading to
muscle weakness in the body’s extremities.| Charcot-Marie-Tooth
disease (CMT) is a neurological disorder named after the three
physicians who first described it in 1886 — Jean-Martin Charcot
and Pierre Marie of France, and Howard Henry Tooth of the United
Kingdom. CMT causes damage to the peripheral nerves, which carry
signals from the brain and spinal cord to the muscles, and relay
sensations, such as pain and touch, to the brain and spinal cord
from the rest of the body. There are a number of types of CMT.
CMT causes muscle weakness and atrophy, and some loss of
sensation in the feet, the lower legs, the hands and the
forearms. It also often causes contractures (stiffened joints
due to abnormal tightening of muscles and associated tissues),
and sometimes, curvature of the spine (scoliosis). At the severe
end of the CMT spectrum, the disease can affect nerves other
than those that go to and from the extremities. If the nerves
that go to and from t