Labeled Probes and Detection Systems In PNA, the sugar phosphate
backbone of DNA/RNA has been replaced by a synthetic peptide
backbone keeping the distances between bases exactly the same as
in DNA/RNA. The increase in affinity is evident from the
increase in the Tm of 1-1.5 °C per base pair. Further, the PNAs
are very stable molecules. Experiments have shown virtually no
degradation by DNases, RNases, proteinases or peptidases. In
this section, you will find Dako's molecular pathology products
which are not intended for FISH. The probes are either
visualized using the GenPoint™ CSA System, In Situ Hybridization
Detection System, PNA ISH Dectection System or Chemiluminescent
System for Nucleic Acid Blotting. Human condyloma stained with a
HPV Type 11, DNA probe.