Progress, and Applications of the Human Genome Project Sponsored
by the U.S. Department of Energy Human Genome Program Human
Genome News Archive Edition In this issue... Also available in
pdf. 1997 Santa Fe Highlights In the News Deciphering the
function of each human gene is a daunting prospect that will
continue far past the projected 2005 deadline for completing the
Human Genome Project. Researchers use model organisms such as
the laboratory mouse to help guide these explorations. In Santa
Fe, Eddy Rubin (Lawrence Berkeley National Laboratory) and
Monica Justice (Oak Ridge National Laboratory) discussed the
value of detailed comparative mouse and human linkage maps and
the technologies available for manipulating the mouse genome.
Rubin described an in vivo approach for tracking down gene
function. His group has generated YAC and P1 transgenic mice
panels that contain defined contiguous regions of the human
genome. The mice are assessed for a phenotype attributed to a
candidate genomic region such as the hu