2007 Progress Report - Executive Summary Medication empowers the
biological system (body, organ or cell) to combat infections or
genetic defects in an attempt to bring the system back to a
homeostatic state. Drug cocktails, which simultaneously affect
several pathways of the overall system, have been shown to be
extremely powerful in controlling complex diseases such as AIDS,
the HIV infection. Figure on the right shows the historical AIDS
clinical data that illustrates the revolutionary impact of using
drugs in combination, noting the nearly 60% reduction of deaths
after the appearance of the first HIV drug combination in 1995.
However, the roadblock is finding a cocktail with the most
effective drug concentration from millions of possible
combinations, a proverbial daunting task of finding a needle in
the haystack. The Center for Cell Control (CCC,
CenterForCellControl.org) has demonstrated that smart search
algorithms can efficiently identify the most potent drug
cocktail in tens of iterations from a large