Primary biliary cirrhosis is a disease of the liver marked by
the slow destruction of the bile ducts. When this ducts are
damaged bile builds up in the liver and over time damages the
tissue. Over time primary biliary cirrhosis can result in liver
failure. The cause of the disease us unknown at this time, but
research indicates that there is an immunological basis for the
disease, making it an autoimmune disorder. Signs and symptoms -
pruritus (itchy skin) - jaundice (yellowing of the eyes and
skin) - xanthalasmas (focal collections of cholesterol in the
skin) - fluid retention Diagnosis of primary biliary cirrhosis
can be made using radiological studies, lab tests, and/or doing
a liver biopsy. Liver function tests may show a high serum
alkaline phosphatase. Mitochondrial antibodies are seen in 95%
of the cases (M2 antibodies are more specific). ANF and SMA
antibodies may also be elevated. Symptomatic treatment of
pruritus with cholestyramine. Immunosuppressive therapy in
advanced cases. Liver transplantation