Systemic means affecting the entire body, rather than a single
organ or body part. For example, systemic disorders such as high
blood pressure or systemic diseases such as influenza affect the
entire body. An infection that is in the bloodstream is called a
systemic infection. An infection that affects only one body part
or organ is called a localized infection. Linda J. Vorvick, MD,
Medical Director and Director of Didactic Curriculum, MEDEX
Northwest Division of Physician Assistant Studies, Department of
Family Medicine, UW Medicine, School of Medicine, University of
Washington. Also reviewed by A.D.A.M. Health Solutions, Ebix,
Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz,
Stephanie Slon, and Nissi Wang.