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saved searches - My saved topics - My newsletter A homeobox is a
DNA sequence found within genes that are involved in the
regulation of development (morphogenesis) of animals, fungi and
plants. Genes that have a homeobox are called homeobox genes and
form the homeobox gene family. They were discovered
independently in 1983 by Walter Jakob Gehring and his colleagues
at the University of Basel, Switzerland, and Matthew Scott and
Amy Weiner, who were then working with Thomas Kaufman at Indiana
University in Bloomington. Homeobox genes encode transcription
factors which typically switch on cascades of other genes. The
homeodomain binds DNA in a specific manner. However, the
specificity of a single homeodomain protein is usually not
enough to recognize only its desired targe