Please use this identifier to cite or link to this item:
http://hdl.handle.net/1959.13/42976 - Potential roles of
erythropoietin in the management of anaemia and other
complications diabetes - The University of Newcastle. Faculty of
Health, School of Medicine and Public Health - Erythropoietin
(EPO) is a haematopoietic cytokine, mainly generated in the
renal cortex, and its secretion and action is impaired in
chronic kidney disease (CKD). Early renal damage in diabetes
mellitus (DM) is usually not detected because diabetes-induced
nephron hypertrophy maintains glomerular filtration rate (GFR)
and an elevated plasma creatinine concentration is a relatively
late manifestation of diabetic nephropathy. However, anaemia
occurs more frequently in subjects with DM when compared with
those with non-DM renal disease. While reduced production and a
blunted response to EPO occurs in DM with early renal damage,
other factors including chronic inflammation, autonomic
neuropathy and iron deficiency are also important. Alth