Tri modal imaging of gold dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study.
Aim: To examine the multimodal contrasting ability of gold dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR) computed tomography (CT) and intravascular ultrasound (IVUS) imaging. Materials methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x ray diffraction and Fourier transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments. Results: The contrast enhancing ability of Au*MNPs was shown to be concentration dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal. Conclusion: We demonstrated that Au*MNPs showed concentration dependent contrast enhancing ability in MRI and CT imaging, and for the first time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri modal imaging based theragnostics.
Nanomedicine