Severe Acute Respiratory Syndrome Coronavirus 2 related Acute on chronic Liver Failure
Dear Editor Acute on chronic liver failure (ACLF) is a condition associated with hepatic and extrahepatic organ failure with high short term mortality. The data regarding severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) related ACLF (S ACLF) are scarce. Whether patients with cirrhosis are at a high risk of developing ACLF after coronavirus disease 2019 (COVID 19) needs further elucidation. Here, we report our observation of patients with COVID 19 and ACLF (as per European Association for the Study of the Liver Chronic Liver Failure (EASLCLIF) definition) We prospectively collected the clinical and laboratory data between 1st June and 10th October of 2020. Fifty seven (2.3% of 2460 patients with COVID19 had underlying cirrhosis, and 60% of patients had cirrhosis related symptoms at presentation. The clinical and laboratory data are described in Table 1. Patients with S ACLF (35% had significantly prolonged hospital stay (14.7 17.3 days vs. 5.4 5.3 days, p 0.004) severe COVID 19 illness (25% vs. 3% p 0.03) need for intensive care unit (45% vs. 11% p 0.003) and higher mortality
Journal of Clinical and Experimental Hepatology