Eman Sutrisna
INTRODUCTION Plantain Plantago major L) is a wild plant that known as an old traditional medicine. This plant grows abundantly in many region in Indonesia but still be ignored. Plantago major L has a lot of active substances that show various pharmacological effects, such as anti hypertension, diuretic, antib iotic, anti fungal, anti viral, analgesic, anti inflammati on, anti gout arthritis, blood coagulation, hypoglicaem ic, anti dyspepsia, hepatoprotective, anti oxydant, ABSTRACT This study was to evaluate the effect of Plantago major L extract. on increasing of caspase 3 level on hyper gast inemic rat (Rattus norvegicus model. By experimental study and post test only w ith control group design 20 of rats was divided in to 4 groups. Group I as a negative contr ol was given aquadest per oral. Group II was given Plantago major L. extract 50mg/200gbw rat/day per oral. Group III was given Plantago major L. extract 100mg/200gbw rat/day per oral. Group IV was given Plantago major L. extract 200mg/200gbw rat/day per oral. Omeprazole and Ciprofibrate have been used to induce hypergastrinemia on rats as an anima l model. Blood sample was collected for measurement of gastrin and caspase 3 level after 2 month intervention. There w ere increasing of gastrin level of rats up to 3 4 t imes fold compared to normal level. Statistic analysis show that there we re significantly difference of caspase 3 level betw een groups (p= 0,041; 95%CI) Dose 200mg/200gBW rat/day per oral o f Plantago major L extract are most effective to increase the caspase 3 level. This research can be concluded tha t administration of Plantago major L extract. can increase caspase 3 level indicate that Plantago major L extract has proapoptotic effect on hypergastrinemi a rat (Rattus norvegicus model.