Acrylamide grafted neem (Azadirachta indica) gum polymer: Screening and exploration as a drug release retardant for tablet formulation.
The study was initiated with the intent to synthesize acrylamide grafted neem gum polymer (AAm g NG) and screen its drug release retardation ability both in vitro and in vivo. Different batches (NGP 1 to NGP 9) of tablet formulation were prepared by varying polymer concentration using propranolol HCl and compared with HPMC K100 M and marketed SR tablets. FTIR study proved the grafting phenomenon and showed no incompatibility between AAm g NG and propranolol HCl. AAm g NG showed significant swelling and water retention capacity than NG. AAm g NG was found to be biodegradable and exhibited no toxicity to Artemia salina. After 12 h, NGP 6 showed non significant (p 0.05; f2= 90) percent drug release (80.52 3.41% compare to marketed formulation (79.65 4.08% Significant swelling of the matrix caused slower diffusion of the drug. NGP 6 and marketed formulation in rabbits showed the non significant difference between Cmax and Tmax, hence NGP 6 meets the requirement of sustained release tablets.
Carbohydrate polymers