Response to Uptake of microplastics and related health effects: a critical discussion of Deng et al. Scientific reports 7: 46687, 2017
We would like to thank Dr. Braeuning and other potential readers for their interests in our paper named "Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure" (Deng et al. 2017) After carefully reviewing the critical discussion (Braeuning 2018) there are two main concerns in regard to whether microplastics used in our study could enter mouse tissues and the biomarkers including serum metabolites and tissue histological changes were appropriate to elucidate the biological responses induced by microplastics. We try to respond to these concerns by elucidating the following scientific questions:
Archives of Toxicology