Mass spectral studies of N oxides of chemical weapons convention related aminoethanols by gas chromatography/mass spectrometry after silylation
N Alkylaminoethanols, N,N' dialkylaminoethanols, and triethanolamine are the hydrolyzed products or precursors of V agents/nitrogen mustards. These compounds are prone to undergo oxidation in environmental matrices. Detection of the oxidized products provides a clue for the presence of parent amine compounds and it is an important task in the verification process of chemical weapons convention. Gas chromatography/mass spectrometry is the technique of choice for the detection of most of the chemical warfare agents; however, it is ideal to develop gas chromatography/mass spectrometry techniques for all the possible degradation products of chemical warfare agents as well. In general, the N oxides of amines are expected to be thermally unstable; hence, the gas chromatography/mass spectrometry analysis of the N oxides of triethanolamine, N alkyldiethanolamines and N,N' dialkylaminoethanols is not explored. In this study, the N oxides of chemical weapons convention related aminoethanols (13 compounds) were successfully silylated and then analyzed by gas chromatography/mass spectrometry under electron ionization and chemical ionization techniques. The electron ionization mass spectra showed abundant molecular ions and structure indicative fragment ions including [M (O+CH2CH2OH) The alkyl groups attached to nitrogen resulted in structure specific fragment ions that enable differentiation of isomeric compounds. The methane/chemical ionization spectra showed considerably abundant [M+H] >10% and the expected adduct ions. The retention indices of all the compounds were calculated using Van den Dool's formula. The gas chromatography/mass spectrometry data together with retention index values could be used for unambiguous identification of the N oxides of aminoethanols during off site analysis or proficiency tests.
European journal of mass spectrometry