Intratumoral accumulation of gut microbiota facilitates CD47 based immunotherapy via STING signaling
The gut microbiome modulates gut immunity and affects the host response to cancer immunotherapy, but how microbiota influence the tumor microenvironment remains unclear. This study reveals that some commensal gut microbiota accumulate inside the distal tumor microenvironment and facilitate CD47 blockade mediated immunity in a STING and interferon dependent fashion.
The Journal of experimental medicine