Association of PIN3 16 bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta analysis
Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16 bp duplication polymorphism of TP53. The aim of our study was to evaluate the role of the PIN3 16 bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta analysis to better understand the correlation with data from other populations. We analyzed the PIN3 16 bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy Malian women using PCR. In addition, we performed a meta analysis of case control study data from international databases, including Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science. Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot. In the studied Malian patients, a significant association of PIN3 16 bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2 A2A2 vs. A1A1: OR 2.26, CI 95% 1.08 4.73; P 0.02) and additive (A2 vs. A1: OR 1.87, CI 95% 1.05 3.33; P 0.03) models, but not in the recessive model (P 0.38) In the meta analysis, nineteen (19) articles were included with a total of 6018 disease cases and 4456 controls. Except for the dominant model (P 0.15) an increased risk of breast cancer was detected with the recessive (OR 1.46, 95% CI 1.15 1.85; P 0.002) and additive (OR 1.11, 95% CI 1.02 1.19; P 0.01) models. The case control study showed that PIN3 16 bp duplication polymorphism of TP53 is a significant risk factor for breast cancer in Malian women. These findings are supported by data from the meta analysis carried out on different ethnic groups around the world.
BMC Medical Genetics