NITROALKENES IN DIVERSE SYNTHESIS OF HETEROCYCLIC COMPOUNDS WITH TWO OR THREE HETEROATOMS: RECENT ADVANCES
This chapter highlights the literature of one of the most privileged substrates in the field of heterocyclic chemistry. Nitroalkenes as versatile organic substrates have been used extensively in direct and diverse synthesis of heterocyclic compounds. We review here the applications of nitroalkenes and their derivatives such as nitrostyrenes, Morita Baylis Hillman (MBH) acetates or bromides of nitroalkenes, 1,1bis(methylthio) 2 nitroethylene, and nitroepoxides in the synthesis of heterocyclic scaffolds with two or three heteroatoms. Following a brief introduction about nitroalkenes, synthetic routes to access heterocyclic scaffolds, exclusively diverse heterocyclic motifs containing two or three heteroatoms such as imidazoles, pyrazoles, triazoles, thiazoles, thiazines, isoxazolines, pyrimidines, imidazopyridines, benzodiazepines as well as bicyclic compounds have been summarized. These significant molecules were synthesized through various synthetic strategies including multi component reactions, Michael addition reactions, [m+n] cycloadditions, asymmetric processes, MBH reaction and cascade/domino/tandem protocols.