Fabrication of b cyclodextrin containing AIE active polymeric composites through formation of dynamic phenylboronic borate and their theranostic applications
Since the first discovery by Tang in 2001, aggregation induced emission (AIE) phenomenon has attracted considerable research interest in various fields. In this contribution, AIE active composites (named as An HPG b CD) have been fabricated via conjugation of AIE active compound An B(OH)2 and hyperbranched polyglycerol functionalized b cyclodextrin (HPG b CD) based on dynamic phenyl borate for the first time. The potential biomedical applications of these AIE active composites for biological imaging and drug delivery applications were further explored. The successful preparation of An HPG b CD composites was confirmed through a series of characterization techniques. The An HPG b CD composites possess great water dispersibility, low cytotoxicity, excellent fluorescence properties and uniform size and morphology, which make them promising for cell imaging. Furthermore, the cavities of An HPG b CD composites could be utilized for loading with doxorubicin for drug delivery applications. In conclusion, we have developed a novel method for fabrication of AIE active An HPG b CD composites through formation of dynamic phenylboronic borate between b cyclodextrin containing hyperbranched polyglycerol and phenylboronic containing AIE dye. These AIE active composites are of great potential in biological imaging and drug delivery applications.
Cellulose