Phosphine mediated sequential annulations of allenyl ketone and isocyanide: a bicyclization strategy to access a furan fused eight membered ring and a spirocycle.
Phosphine mediated cascade annulations of allenyl ketone and isocyanide have been disclosed. Two molecular allenyl ketones work as different four carbon synthons to form two rings, respectively, and thus enables the efficient synthesis of a furan fused eight membered ring and a spirocycle.
Chemical communications