The hubs of the human connectome are generally implicated in the anatomy of brain disorders
See Sporns (doi:10.1093/brain/awu148) for a scientific commentary on this article. Brain networks contain a minority of highly connected hub nodes with high topological value and biological cost. Using network analysis of DTI data from healthy volunteers, and meta analyses of published MRI studies in 26 brain disorders, Crossley et al. show that lesions across disorders tend to be concentrated at hubs.
Brain a journal of neurology