O2 03 02 Preliminary cross sectional and longitudinal cortical thickness analyses of MRI data from the Alzheimer's disease neuroimaging initiative (ADNI) using morphometry birn methods
healthy controls, were analyzed using voxel based analysis and high dimensional pattern classification. Diagnostic sensitivity and specificity of spatial patterns of regional brain atrophy found to be characteristic of AD and FTD were determined via cross validation and via split sample methods. Results: Complex spatial patterns of relatively reduced brain volumes were identified, including temporal, orbitofrontal and cingulate regions, which were predominately characteristic of either AD or FTD. These patterns provided 100% diagnostic accuracy, when used to separate AD or FTD from healthy controls. The ability to correctly distinguish AD from FTD averaged 84.3% All estimates of diagnostic accuracy were determined via cross validation. Conclusion: ADand FTD specific patterns of brain atrophy can be detected with high accuracy using high dimensional pattern classification of MRI scans obtained in a typical clinical setting.
Alzheimer's Dementia