THE EFECT OF SMOKING IN PARATHYROID HORMONE (PTH) AND ALKALINE PHOSPHTASE (ALP)
Background: Smoking is one of the most common practices and believed to be associated with decreased bone density and calcium absorption therefore abnormalities of both PTH and ALP are expected in smokers. Objectives: This study was aimed to study the effect smocking in serum levels of PTH and ALP activity in comparison to healthy non smokers. Methods: this is a cross sectional study conducted during the period from August to December 2011. Blood samples were drawn from 50 apparently healthy cigarette smokers' volunteers (as test group) and 50 apparently healthy non smokers' volunteers' age, BMI and gender matched as control group. Serum levels of parathyroid hormone and ALP activity was analysed for both groups by using commercial reagent kits from DRG diagnostic and commercial reagent kits from Bio system Company by Selector E, respectively. Data were analysed using SPSS v 16. Results: The serum level of PTH in smokers (14.174+ 5.89 pg/ml) was significantly decreased than nonsmokers (26.874+ 11.8627 pg/ml) p.value <0.0001. The activity of ALP was significantly increased in smokers compared to non smokers (119.24+ 31.2 vs 89.70+ 20.28 u/l p.value 0.0001) In test group serum parathyroid hormone was negatively correlated,while alkaline phosphatase activity was positively correlated with both the duration of smoking (per years)and the number of cigarette smoked per day. Conclusion: From this study, it is concluded that; cigarette smoking is associated with low serum parathyroid hormone and increased serum alkaline phosphates activity and more alteration is expected with both increased duration of smoking per year and number of cigarettes smoked per day.