Increased DKA at presentation among newly diagnosed type 1 diabetes patients with or without COVID 19: Data from a multi site surveillance registry
To the Editor The severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) global pandemic has marked 2020. There have been initial reports on coronavirus disease 2019 (COVID 19) association with diabetes mellitus and diabetic ketoacidosis (DKA) Early diabetogenic effect of COVID 19 and glucose homeostasis is postulated to be due to the angiotensinconverting enzyme 2 mediated damage of the pancreatic islet cells, leading to hyperglycemia associated with underproduction of insulin. There might also be increased demand for insulin and increased insulin resistance related to cytokine release following COVID 19. An international registry has been established to further understand the different mechanisms and types of diabetes that might co occur during or after COVID 19. This report focuses on patients with newly diagnosed type 1 diabetes (T1D) simultaneously presenting with COVID 19 in comparison with a cohort of newly diagnosed patients that tested negative for COVID 19 during the same period.
Journal of diabetes