Intervertebral Disk Mediated Postoperative Epidural Fibrosis Experimental Model and Methods of Prevention
The etiology and pathogenesis creates a lot of discussion, and selection of methods of treatment and prevention continues. In this study we used 36 male Wistar rats, each weighing 250 30 g; LIV laminectomy with dura mater exposition was done in 12 rats, and then, 0.3 cc of elements of suspension of autologous intervertebral disk were implicated on dura mater. In 12 animals laminectomy was followed by application of a 5 x 6 mm sheet of ReperenTM on the exposed duraTM. Histological assessment of the lumbar spine of rats observed that the elements of autologous intervertebral disk play the role of inflammation trigger, which cause postoperative scar and epidural fibrosis. In another part of the experimental study we revealed that ReperenTM to prevent excessive epidural fibrosis. So, the experimental model and methods of prevention postoperative epidural fibrosis can be widely used in experimental medicine for research of epidural scar adhesion pathogenesis and for searching the ways of treatment and prevention of the disease in human.