HER2 targeted biological macromolecule modified liposomes for improved efficacy of capecitabine in breast cancer.
Chitosan, a biological macromolecule is gaining research attention in recent years for its tumor targeting potential by improving cell uptake. The present research reports the beneficial effects of surface modified chitosan and tumor homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using cholesterol THP conjugate (CTHP CAP LPs) to achieve active targeting through HER2 receptors. THP CAP LPs significantly improved the specificity and efficacy of CAP by improving cell uptake, cytotoxicity and tumor regression in tumor bearing mice. THP CAP LPs, therefore, is a promising approach to improve the anticancer effects of CAP.
International journal of biological macromolecules