The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype
Abstract The aim of this study was to evaluate the effect of hormone therapy (HT) in the endothelial function of 46,XY disorders of sexual development (DSD) patients with female phenotype. Biochemical and ultrasound measurements were performed in 20 patients at initiation of oral 2 mg 17b estradiol/1 mg norethisterone acetate, and after 6 months of therapy. Lipid profile, including total cholesterol (TC) LDL, HDL, triglycerides (TG) and Atherogenic Index of Plasma (AIP) as well as levels of VE Cadherin, E Selectin, Thrombomodulin and vWf were determined. Ultrasonographic examinations included evaluation of flow mediated dilatation (FMD) and measurement of Carotid and Femoral Intima Media Thickness (IMT) HT raised HDL (35.4 mg/dl versus 40.1 mg/dl, p 0.019) while lowering TG (166 mg/dl versus 109 mg/dl, p 0.026) and AIP (0.24 versus 0.04, p 0.007) No changes were noted in TC and LDL (215.7 mg/dl versus 192.25 mg/dl and 87.46 mg/dl versus 76.35 mg/dl, respectively) There was significant reduction of VE Cadherin (4.05 ng/ml versus 2.20 ng/ml, p 0.002) and E selectin (73.98 ng/ml versus 56.73 ng/ml, p 0.004) No change was observed in Thrombomodulin and vWf (11.76 ng/ml versus 13.90 ng/ml and 80.75% versus 79.55% respectively) FMD improved significantly (5.4% versus 8.15% p 0.003) while only carotid bulb IMT decreased significantly (0.65 mm versus 0.60 mm, p 0.018) Overall, HT was found to improve biochemical and ultrasound markers of endothelial function in 46,XY DSD patients with female phenotype. Chinese abstract Ben Shi Yan Zhi Zai Ping Gu Ji Su Zhi Liao (HT)Dui Xing Fa Yu Yi Chang Nu Xing Biao Xing Huan Zhe (46,XY)Nei Pi Gong Neng De Ying Xiang Dui 20Ming Huan Zhe Jin Xing Sheng Hua He Chao Sheng Ce Liang ,Zhi Liao De Chu Shi Kou Fu Ji Liang Wei 2mg 17b Ci Er Chun /1mgCu Suan Gui Nuo Tong ,Zhi Liao 6Ge Yue Hou ,Ce Ding Qi Zhi Lei Dai Xie (Bao Gua Zong Dan Gu Chun [TC] LDL, HDL, Gan You San Zhi [TG] Xie Jiang Zhi Dong Mai Zhou Yang Ying Hua Zhi Shu [AIP],Yi Ji Xie Guan Nei Pi Gai Nian Dan Bai EXuan Ze Su Xie Shuan Diao Jie Dan Bai He vWFYin Zi Chao Sheng Jian Cha Bao Gua Xie Liu Jie Dao De Xie Guan Kuo Zhang (FMD)He Jing Dong Mai He Gu Dong Mai Nei Zhong Mo Hou Du (IMT)De Ce Liang HTTi Gao Liao HDLShui Ping (35.4mg/dlHe 40.1mg/dl,p=0.019),Tong Shi Jiang Di TG(166mg/dlHe 109mg/dl,p=0.026)He AIP(0.24He 0.04, p=0.007) TCHe LDLWei Jian Dao Ming Xian Bian Hua (Fen Bie Wei 215.7 mg/dlHe 192.25 mg/dl,87.46 mg/dlHe 76.35 mg/dl) Xie Guan Nei Pi Gai Nian Dan Bai (4.05 ng/mlHe 2.20 ng/ml, p=0.002) He EXuan Ze Su (73.98 ng/mlHe 56.73 ng/ml, p=0.004)Xian Zhu Jiang Di Xie Shuan Diao Jie Dan Bai He vWFYin Zi Wei Jian Ce Dao Ming Xian Bian Hua (Fen Bie Wei 11.76 ng/mlHe 13.90 ng/ml and 80.75%He 79.55% FMD Xian Zhu Ti Gao (5.4%He 8.15% p=0.003) Er Zhi You Jing Dong Mai Dou Bu IMTXian Zhu Jiang Di (0.65mm He 0.60 mm, p=0.018) Zong Zhi ,HTBei Fa Xian Ke Yi Ti Gao Xing Fa Yu Yi Chang Nu Xing Biao Xing Huan Zhe (46,XY)Nei Pi Gong Neng De Sheng Hua He Chao Sheng Jian Ce Biao Ji
Gynecological endocrinology the official journal of the International Society of Gynecological Endocrinology