Inclusion complex of linalool and b cyclodextrin
Abstract( Linalool is a monoterpene alcohol which is present in the essential oils of several aromatic plants. Recent studies suggest that linalool has antimicrobial, anti inflammatory, anticancer, antioxidant, and antinociceptive properties in different animal models. The aim of this study was to prepare and characterize inclusion complexes of linalool with b cyclodextrin (b CD) Equimolar binary linalool/b CD systems were prepared by physical mixture, paste (PM) and slurry methods (SC) and characterized by differential scanning calorimetry, thermogravimetric analysis, FT IR spectroscopy, X ray diffractometry, Karl Fisher titration, and scanning electron microscopy. Thermal characterization indicates the occurrence of complexation, mainly in paste complexes, which is present in the interval from 140 to 280 degC a gradual mass loss (4.6 probably related to linalool loss. FT IR spectra showed changes that may be related to the formation of intermolecular hydrogen bonds between linalool and b CD. The new solid phase formed using the PM and SC methods, had a crystal structure which was different from the original morphology of b CD.
Journal of Thermal Analysis and Calorimetry