Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate
Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2 chloro N (3 methylisoxazol 5 yl) acetamide (5 10 and 15 at 70 80 degC for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 degC for 7 h to afford the corresponding (SCN) These were stirred with Deflazacort drug to achieve the Deflazacort loading (SCN) which, compressed with calcium starch glycolate (CaSgly) to give the corresponding tablets. The pH 2. 1 and concentration of SCN 10 /CaSgly (1:4) was found to be important parameters in controlling the release profiles.
Fibers and Polymers