Expression and clinical significance of Her 2/neu and NF kBp65 in gastric carcinoma
Objective:The expression and clinical significance of Her 2/neu and NF kBp65 in gastric carcinoma tissue is investigated.Methods:The expressions of Her 2/neu and NF kBp65 were tested by PV 9000 immunohistochemical technique in 80 cases of gastric cancer and 30 cases of adjacent normal tissue,the relationship between their expression and clinicopathological features of gastric carcinoma was analyzed.Results:The positive rates of Her 2/neu in gastric carcinoma and adjacent normal tissue were respectively 17.3% and 3.3%(P0.05),over expression of Her 2/neu was significantly correlated with the degree of histodifferentiation and lymphatic metastasis(P0.05).The positive rates of NF kBp65 in gastric carcinoma and adjacent normal tissue were respectively 58.7% and 11.4%(P0.05),expression of NF kBp65 was significantly correlated with degree of histodifferentiation,the depth of invasion and lymphatic metastasis(P0.05).Her 2/neu was positively correlated with NF kBp65 in gastric cancer tissue.Conclusion:High expressions of Her 2/neu and NF kBp65 were significantly correlated with development of gastric carcinogenesis.Combining detection of Her 2/neu and NF kBp65 expression is meaningful to guide molecule targeted therapy and evaluate the prognosis of patients.