Evaluation of human and non human primate antibody binding to pig cells lacking GGTA1/CMAH/b4GalNT2 genes
Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The b4GalNT2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan based species incompatibilities, we examined human and non human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate modifying genes.
Xenotransplantation