Computational modeling of seizure spread on a cortical surface
In the field of computational epilepsy, neural field models helped to understand some large scale features of seizure dynamics. These insights however remain on general levels, without translation to the clinical settings via personalization of the model with the patient specific structure. In particular, a link was suggested between epileptic seizures spreading across the cortical surface and the so called theta alpha activity (TAA) pattern seen on intracranial electrographic signals, yet this link was not demonstrated on a patient specific level. Here we present a single patient computational study linking the seizure spreading across the patient specific cortical surface with a specific instance of the TAA pattern recorded in the patient. Using the realistic geometry of the cortical surface we perform the simulations of seizure dynamics in The Virtual Brain platform, and we show that the simulated electrographic signals qualitatively agree with the recorded signals. Furthermore, the comparison with the simulations performed on surrogate surfaces reveals that the best quantitative fit is obtained for the real surface. The work illustrates how the patient specific cortical geometry can be utilized in The Virtual Brain for personalized model building, and the importance of such approach.