Diagnostic values of measurements of QRS complex duration, plasma B type natriuretic peptide and high sensitive C reactive protein in patients with heart failure
Objective To investigate the diagnostic values of measurements of QRS complex duration,plasma B type natriuretic peptide BNP) and high sensitive C reactive protein hs CRP)in patients with chronic heart failure.Methods A total of 150 patients with chronic heart failure were admitted,and 45 patients without heart failure were choosed as controls.QRS complex duration,plasma BNP,hs CRP concentration,left ventricular ejection fraction LVEF) and NYHA functional classification of the patients were measured.Results The QRS complex duration,and the plasma levels of BNP and hsCRP were higher in CHF group than those in the control group (P 0.05) and were elevated with the increase of the NYHA functional classification.The QRS complex duration and plasma levels of BNP were correlated positively with NYHA functional classification in CHF P 0.05) and were correlated negatively with LVEF.There was no relationship between plasma hs CRP and NYHA functional classification,LVEF (P 0.05).Conclusions QRS complex duration and the levels of plasma BNP and hs CRP concentration are mcreased with severity of NYHA classification.QRS complex duration and plasma BNP are related more closely to heart function,and were effective biological parameters for assessing heart dysfunction and guiding treatment in CHF. Key words: Chronic heart failure; QRS complex duration; B type natriuretic peptide; C reactive protein