Revolutionizing immunology with single cell RNA sequencing
The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Identifying heterogeneity of immune cells is the key to understanding the immune system. Advanced single cell RNA sequencing (scRNA seq) technologies are revolutionizing our ability to study immunology. By measuring transcriptomes at the single cell level, scRNA seq enables identification of cellular heterogeneity in far greater detail than conventional methods. In this review, we introduce the existing scRNA seq technologies and present their strengths and weaknesses. We also discuss potential applications and future innovations of scRNA seq in immunology.
Cellular Molecular Immunology