Iron Catalyzed Highly Enantioselective Hydrosilylation of Unactivated Terminal Alkenes.
The iron catalyzed highly Markovnikov type selective and enantioselective hydrosilylation of terminal aliphatic alkenes with good functional group tolerance is developed. This operationally simple protocol uses earth abundant transition metal catalyst, readily available aliphatic alkenes and hydrosilanes to construct valuable chiral organosilanes with better than 99% ee in most cases. The chiral aliphatic alkan 2 ol and chiral dihydroxysilane as an analogue of ketone could be efficiently synthesized via further derivatization of chiral organosilanes without any racemization.
Journal of the American Chemical Society