Vitamin D, an inflammatory activity marker for spondyloarthritis?
Summary In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow up of the patient. Purpose The aim of this study is to determine the association between 25 hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis. Methodology This study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of Hospital General Universitario de Ciudad Real between September 2016 and September 2018 is under consideration. The association between 25 hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level. Results Initial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA) Twenty eight percent of patients showed increased levels of acute phase reactants, and 82% exhibited 25 hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95% 2.92 21.23, p 0.0001) Conclusion In this study, an association was found between those patients with spondyloarthritis who had a 25 hydroxyvitamin D deficiency and disease activity. Despite these results, a 1 year follow up of these patients using two or more measurements of activity and 25 hydroxyvitamin D levels would be needed to corroborate these data.
Archives of Osteoporosis