Smoking as a factor of immune deficiency deepening in patients with chronic obstructive pulmonary disease and chronic pancreatitis
The objective of the work to study the state of humoral link of the immune system in patients with chronic pancreatitis with concomitant COPD and without it. There were examined 90 patients with COPD in combination with chronic pancreatitis (45 women and 45 men) aged 35 86 years, mean age (56.42 4.11 years) and 43 with chronic pancreatitis. Among the examined individuals there were 32 persons with chronic pancreatitis and COPD I st. (35.5 and 58 persons with chronic pancreatitis and COPD II st. (64.5 Duration of the disease from 1 to 25 years, the combination of diseases from 1 to 10 years. There were 20 (22.2 active smokers among surveyed patients. The duration of the smoking 10 30 years, middle duration (22.75 1.20) years. The smoking experience of 9 patients was 10 20 packs/years, 11 more than 20 pack/years. Methods of examination: general clinical, laboratory, instrumental, questioning, testing, statistical methods. In patients with chronic pancreatitis without COPD, the level of all studied classes of Ig was significantly increased (IgG 10.4 IgA 13.1 IgM 45.9 P 0.05) Disbalance in immunoglobulines level was detected in patients with COPD with a significant decrease (P 0.05) in IgG and IgA levels (by 7.9 and 27.3 respectively) and IgM increased (by 76.7 This indicates an imbalance in the functioning of the cellular immune system with the formation of a secondary immune deficiency. The increase in the level of immune complexes in both groups (2.6 and 3.2 times, respectively) showed the presence of torpid inflammatory process in COPD. The presence of tobacco smoking in patients with chronic pancreatitis and COPD significantly deepened the changes in the immune system in comparison with non smokers.
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