Metotreksat'in Karaciger ve Bobrekte Neden Oldugu Hasarda Oksidatif Stresin Rolu
Ozet Metotreksat (MTX) bazi kanser hastalarinin vazgecilmez ilacidir. Fakat MTX'in olusturdugu yan etkiler, doz kisitlamasina veya tedavinin sonlandirilmasina goturebilir bu da hastanin sag kalimini azaltir. Bu sebeple MTX'in en onemli yan etkilerinden olan hepatotoksisite ve nefrotoksisitenin olusum mekanizmasinin bilinmesi ve buna karsi onlemlerin alinmasi oldukca onemlidir. Yapilan bircok calisma ile MTX'in sebep oldugu hepatotoksisite ve nefrotoksisitede genellikle reaktif oksijen turleri (ROT)'nin meydana getirdigi oksidatif hasar sorumlu tutulmustur. Bu nedenle de olusacak bu yan etkilerden korunmak icin antioksidan ajanlarla birlikte kullanilmasi gerekliligi on plana cikmistir. Anahtar Kelimeler Antioksidan; Metotreksat; Oksidatif Stres; Reaktif Oksijen Turleri Abstract Methotrexate (MTX) is one of the indispensable chemotherapeutic agents for cancer patients. But, MTX induce some adverse effects such as nephrotoxicity and hepatotoxicity. Thus cause dose limitations and terminate the cancer therapy. This will cause decrease in the survival of cancer patients. Hence, we aimed to summarize the MTX's action mechanism on hepatotoxicity and nephrotoxicity, which of those are most known adverse effects of MTX. However, taking precautions in MTX treatment is crucial in chemotherapy. According to the literatures, reactive oxygen species (ROS) triggered oxidative stress is responsible in MTX induced hepatotoxicity and nephrotoxicity. Hence, the MTX treatment must be accompanied with antioxidants to protect the patients from those adverse effects. Keywords Antioxidant; Methotrexate; Oxidative stress; Reactive Oxygen Species