ANTI INFLAMMATORY ACTIVITY TEST OF ETHANOLIC EXTRACT OF BANANA LEAF (Musa paradisiaca L. ON CARRAGEENAN INDUCED PAW EDEMA IN WHITE RATS (Rattus norvegicus L.
Anti inflammatory activity test of ethanolic extract of banana leaf (Musa Paradisiaca L. on carrageenan induced paw edema in white male rats (Rattus novergicus L. has been conducted. It was aimed to investigate and to determine the anti inflammatory activity and its effective dose. The extract was prepared by maceration method using ethanol 96% Anti inflammatory activity test was performed in five different groups. Each group consisted of 5 rats. The 1st group (negative control) was given 0.5% CMC Na suspension; the 2nd group (positive control) was given diclofenac sodium 9 mg/KgBW; the 3rd, 4th, and 5th groups were successively given the banana leaf extract as much as 500, 750 and 1000 mg/KgBW. Each rat was then induced by 1% carrageenan and tested using subplantar method. The inflamed paw diameter was measured using a calliper while the inflamed paw volume using pletysmometer. The measurements were done for 6 hours long with intervals of 60 minutes. The data was statistically analyzed using ANOVA (analysis of variance) The results showed that the negative control had a significant difference with the other treatment groups which did not show any anti inflammatory effect. In conclusion, ethanolic extract of banana leaf has effective anti inflammatory activity at a dose of 750 mg/KgBW. Keywords: Ethanolic Extract, Banana (Musa paradisiaca L. Anti inflammation, Carrageenan, Inflamed Paw diameter, Inflamed Paw Volume.