Off Label Use of Multitarget Stool DNA Testing in Primary Care.
INTRODUCTION We evaluated the off label use of multitarget stool DNA (mt sDNA) testing in the primary care setting. METHODS We reviewed all mt sDNA orders between July 1, 2018, and June 30, 2019, to determine the frequency of off label mt sDNA orders. RESULTS Nine hundred two patients with mt sDNA orders were evaluated, of which 160/902 patients (17.7% met at least 1 criterion for off label mt sDNA order. Increasing age was associated with off label order (Odds Ratio [OR] 2.32 [95% CI, 1.86 2.89] for every 10 year increase in age, P 0.0001) On multivariate analysis, increased age (OR 1.04 [1.02 1.06] P 0.001) and need for diagnostic colonoscopy (OR 2.9 [1.01 8.34] P 0.048) were associated with a positive mt sDNA result. DISCUSSION Off label mt sDNA testing is common, and further efforts are needed to educate patients and providers on appropriate use of mt sDNA for colorectal cancer screening.
The American journal of gastroenterology