Exercise and taurine in inflammation, cognition, and peripheral markers of blood brain barrier integrity in older women.
Immunosenescence contribute to increase the blood brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti inflammatory effect of exercise and taurine supplementation on peripheral markers of BBB, inflammation, and cognition of elderly women. Forty eight elderly women (age, 83.58 6.9 years) participated in the study, and were allocated into combined exercise training (CET: n 13) taurine supplementation (TAU: n 12) exercise training associated with taurine (CET+TAU: n 11) or control (CG: n 12) groups. Exercise was applied twice a week (multi modal exercise) Taurine ingestion was 1.5 g. once a day. Participants were evaluated before and after 14 weeks of intervention. Plasma levels of interleukin (IL) 1b, IL 1ra, IL 6, IL 10, IL 17, tumor necrosis factor alpha (TNF a) and serum concentration of S100b and neuron specific enolase (NSE) were determined. The mini mental state examination (MMSE) was also applied. Concentrations of S100b were maintained in all intervention groups, while a subtle increase in the CG was found. NSE levels increased only in TAU group (p 0.05) CET reduced TNF a, IL 6, and IL 1b/IL 1ra, IL 6/IL10, and TNF a/IL 10 ratios (p 0.05) TAU decreased the IL 1b/IL 1ra ratio (p 0.05) MMSE score increased only in the CET+TAU group (p 0.05) Multiple regression analysis showed that there was a trend for changes in IL 1b and the Charlson Comorbidity Index to be independently associated with changes in S100b. Exercise and taurine decreased inflammation, and maintained the BBB integrity in elderly women. Exercise emerged as an important tool to improve brain health even when started at advanced ages.
Applied physiology, nutrition, and metabolism Physiologie appliquee, nutrition et metabolisme