What opens two strands of dna?
chromosome
replication
adenylate
helicase
DNA replication. The two DNA strands are opened by helicase. The strands are held open by a single strand of binding proteins, preventing premature reannealing. Topoisomerase solves the problem caused by tension generated by winding/unwinding of DNA. This enzyme wraps around DNA and makes a cut permitting the helix to spin and relax. Once DNA is relaxed, topoisomerase reconnects broken strands. DNA primase synthesizes a short RNA primer which initiates the Okazaki fragment. Okazaki fragments are attached by DNA ligase.