sentences: Hybrid learning methods use theoretical knowledge of a domain and a set of classified examples to develop a method for accurately classifying examples not seen during training. The challenge of hybrid learning systems is to use the information provided by one source of information to offset information missing from the other source. By so doing, a hybrid learning system should learn more effectively than systems that use only one of the information sources. KBANN(Knowledge-Based Artificial Neural Networks) is a hybrid learning system built on top of connectionist learning techniques. It maps problem-specific “domain theories”, represented in propositional logic, into neural networks and then refines this reformulated knowledge using backpropagation. KBANN is evaluated by extensive empirical tests on two problems from molecular biology. Among other results, these tests show that the networks created by KBANN generalize better than a wide variety of learning systems, as well as several techniques proposed by biologists.