Dengue is a life threatening disease prevalent in several developed as well as developing countries like India. This is a virus born disease caused by breeding of Aedes mosquito. Datasets that are available for dengue describe information about the patients suffering with dengue disease and without dengue disease along with their symptoms like: Fever Temperature, WBC, Platelets, Severe Headache, Vomiting, Metallic Taste, Joint Pain, Appetite, Diarrhea, Hematocrit, Hemoglobin, and how many days suffer in different city. In this paper we discuss various algorithm approaches of data mining that have been utilized for dengue disease prediction. Data mining is a well known technique used by health organizations for classification of diseases such as dengue, diabetes and cancer in bioinformatics research. In the proposed approach we have used WEKA with 10 cross validation to evaluate data and compare results. Weka has an extensive collection of different machine learning and data mining algorithms. In this paper we have firstly classified the dengue data set and then compared the different data mining techniques in weka through Explorer, knowledge flow and Experimenter interfaces. Furthermore in order to validate our approach we have used a dengue dataset with 108 instances but weka used 99 rows and 18 attributes to determine the prediction of disease and their accuracy using classifications of different algorithms to find out the best performance. The main objective of this paper is to classify data and assist the users in extracting useful information from data and easily identify a suitable algorithm for accurate predictive model from it.