The team qualified for the sixth time for the CONCACAF Champions League, in the 2019 edition.[16] In the Round of 16, Los Guerreros achieved an 11-2 win on aggregate against Honduran side Marathón.[17] In the following stage, Santos Laguna defeated the New York Red Bulls in both legs, by 2-0 and 4-2 respectively.[18] In the semi-finals, however, the team lost 5-3 on aggregate against Tigres UANL and failed to advance to the finals.[19]