The major allergens in cow milk are αs1-, αs2-, β-, and κ-casein and the whey proteins α- and β-lactoglobulin.[1] The body may raise an antibody-based immuneresponse or a cell-based immune response to these allergens.[1] The reaction to cow milk is caused by IgE and non-IgE mediated responses, with the latter being the most frequent.[1] The non-IgE reactions involving the gastrointestinal tract are typically delayed while IgE reactions such as hives are much more immediate.[1]