1968 WHO Programme established. International ADR terminology and drug dictionary 1969 Definition of ADR 1978 Operations transferred to the UMC; setting-up of relational ADR database. Regular WHO Programme member meetings 1981 Computerised version of WHO Drug Dictionary available to all 1982 ATC classification coding of all medicinal products 1985 International expert review panel created 1991 On-line WHO database search programme available to national centres 1991 Definitions of adverse event, side effect and causality assessment terms 1993 Windows-based client server program for online database searches 1993 Regular training and educational activities 1994 Methodology for use of denominator data for calculation of ADR reporting rates 1997 Knowledge-detection tool for automated signal detection (BCPNN) 1997 Promotion of communication as a necessary discipline in pharmacovigilance : the 'Erice Declaration' 1998 Internet discussion group for national centres 2001 Start of VigiBase Online project (now VigiFlow) 2002 New database system (VigiBase) 2004 Pattern recognition using the BCPNN on health databases to find safety information.