Otto-Heinrich Drechsler (1 April 1895 – 5 May 1945) was the General Commissioner of Latvia for the Nazi Germany's occupation regime (Reichskommissariat Ostland) during World War II. In this capacity, he played a role in setting up the Riga ghetto and was implicated in the extermination of the Latvian Jews. He committed suicide on 5 May 1945, after being captured by the British forces.