On some of the first crewed missions, three types of medications that were taken into orbit were an anti-nausea, a pain-killer, and a stimulant.[30] By the time of ISS, space crew-persons had almost 200 medications available, with separate pill cabinets for Russians and Americans.[31] One of the many concerns for crewed Mars missions is what pills to bring and how the astronauts would respond to them in different conditions.[30]