Promoted from 2021–22 Segunda División RFEF Relegated from 2021–22 Segunda División Promoted to 2022–23 Segunda División Relegated to 2022–23 Segunda Federación Ceuta Córdoba Eldense Intercity La Nucía Mérida Murcia Numancia Osasuna B Pontevedra Alcorcón Amorebieta Fuenlabrada Real Sociedad B Racing Santander Andorra Albacete Villarreal B Atlético Sanluqueño Betis Deportivo Costa Brava Extremadura (disqualified) Internacional (resigned due to economic problems) Sevilla Atlético Tudelano UCAM Murcia Valladolid Promesas Zamora