The recent rise in the use of electronic cigarettes, many forms of which are designed to be refilled with nicotine-containing "e-liquid" supplied in small plastic bottles, has renewed interest in nicotine overdoses, especially in the possibility of young children ingesting the liquids.[27] A 2015 Public Health England report noted an "unconfirmed newspaper report of a fatal poisoning of a two-year old child" and two published case reports of children of similar age who had recovered after ingesting e-liquid and vomiting.[27] They also noted case reports of suicides by nicotine, where adults drank liquid containing up to 1,500 mg of nicotine.[27] They recovered (helped by vomiting), but an ingestion apparently of about 10,000 mg was fatal, as was an injection.[27] They commented that "Serious nicotine poisoning seems normally prevented by the fact that relatively low doses of nicotine cause nausea and vomiting, which stops users from further intake."[27] Four adults died in the US and Europe, after intentionally ingesting liquid.[28] Two children, one in the US in 2014 and another in Israel in 2013, died after ingesting liquid nicotine.[29]