Human coronavirus 229E (HCoV-229E) is a species of coronavirus which infects humans and bats.[1] The infecting virus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor.[2] Along with Human coronavirus OC43, it is one of the viruses responsible for the common cold.[3][4] The species is a member of the genus Alphacoronavirus and subgenus Duvinacovirus.[5][6]