Eng has received numerous awards and honours including election to the American Society of Clinical Investigation, the Association of American Physicians, a Fellow of AAAS, and the Doris Duke Distinguished Clinical Scientist Award. Eng received the 2005 ATA Van Meter Award, the 2006 Ernst Oppenheimer Award of The Endocrine Society and the 2006 American Cancer Society John Peter Minton, MD, PhD Hero of Hope Research Medal of Honour, 2014 James Ewing Lecturer of the Society of Surgical Oncology and the 2014 AACR-WICR Charlotte Friend Memorial Lecturer. In 2018 Eng was awarded a Medal of Honour for Clinical Research by the American Cancer Society "for her leadership in personalized care, translating genomic and cellular analysis to clinical practice."[10] Eng has also received the Stefanie Spielman Breast Cancer Research Award.[2]