Grayanotoxins are a group of closely related neurotoxins named after Leucothoe grayana, a plant native to Japan originally named for 19th century American botanist Asa Gray.[1] Grayanotoxin I (grayanotaxane-3,5,6,10,14,16-hexol 14-acetate) is also known as andromedotoxin, acetylandromedol, rhodotoxin and asebotoxin.[2] Grayanotoxins are produced by Rhododendron species and other plants in the Ericaceae family. Honey made from the pollen and nectar of these plants also contains grayanotoxins and is commonly referred to as mad honey. Consumption of the plant or any of its secondary products, including mad honey, can cause a very rare poisonous reaction called grayanotoxin poisoning, mad honey disease, honey intoxication, or rhododendron poisoning.[3] It is most frequently produced and consumed in regions of Nepal and Turkey as a recreational drug and traditional medicine.[4]