Abded Mshiho was born in the village of Qal’at Mara, east of Mardin, in 1854 and at the age of 12, in 1866, he joined the Monastery of Mor Hananyo where he began his education. Seven years later, in 1873, he entered the monastic orders, becoming a monk. In 1875, Abded Mshiho was ordained as priest, and in 1886, he was consecrated as a bishop.