The family's heirs sold the rights,[3] and in the 14th century, Cetona was alternatingly ruled by Siena and Orvieto (until 1354), and, after a brief rule by Perugia, was annexed by Siena. An outer wall was built, containing two round towers (1458). Grand Duke Cosimo I de' Medici of Tuscany sold Cetona in 1556, to the marchese Chiappino Vitelli (1519–75), who made the fortress into a private residence, and built the piazza below it, today named Piazza Garibaldi.