At Vilcabamba the state known as the Neo-Inca State was established by Manco, and Vilcabamba became the capital of the state until the death of Tupaq Amaru in 1572. From there, he continued his attacks against the Wankas (one of the most important allies of the Spaniards), having some success after fierce battles, and to the highlands of present-day Bolivia, where after many battles his army was defeated. After many guerrilla battles in the mountainous regions of Vilcabamba, Manco was murdered in 1544 by supporters of Diego de Almagro who had previously assassinated Francisco Pizarro and who were in hiding under Manco's protection.