The façade is preceded by a portico by Gherardo Silvani (1634), built by the Florentine people as vow for the liberation from the plague, and by a bell tower from the 13th century. The interior has a single nave; artworks include a Nativity by Domenico Passignano and a Vocation of St. Peter by Jacopo da Empoli. The presbytery is flanked by two niches by Michelozzo decorated by Luca della Robbia, housing the relics of the Holy Cross and the Madonna's image to which the sanctuary is devoted and, which, according to tradition, was painted by St. Luke himself.