The squadron embarked for the Middle East in April 1941; its personnel initially consisted solely of ground crew, who joined the pilots of No. 260 Squadron RAF to form No. 260/450 Squadron, which briefly operated Hawker Hurricane fighters in Syria. It was not until February 1942 that No. 450 Squadron, now with its own pilots and equipped with Curtiss P-40 Kittyhawk fighters, commenced operations in earnest. Over the next 15 months, it fought in the North African and Tunisian Campaigns in both fighter and fighter-bomber roles, claiming 49 German and Italian aircraft destroyed in the air and earning the nickname "The Desert Harassers".