Dark skin offers great protection against UVR because of its eumelanin content, the UVR-absorbing capabilities of large melanosomes, and because eumelanin can be mobilized faster and brought to the surface of the skin from the depths of the epidermis.[1] For the same body region, light- and dark-skinned individuals have similar numbers of melanocytes (there is considerable variation between different body regions), but pigment-containing organelles, called melanosomes, are larger and more numerous in dark-skinned individuals. Keratocytes from dark skin cocultured with melanocytes give rise to a melanosome distribution pattern characteristic of dark skin.[52][53] Melanosomes are not in aggregated state in darkly pigmented skin compared to lightly pigmented skin.