In 1202 the comune gained local autonomy, remaining nevertheless a dependency of Lucca. In the 14th century Uzzano, like other comuni of the Valdinievole, passed under the dominion of Florence, with which it was joined until the unification of Italy, when it was returned to the jurisdiction of Lucca, and the separated by the creation of the province of Pistoia (1928). In 1963, the southern section of Uzzano was separated to form the comune of Chiesina Uzzanese.