The Sisters Brothers Theatrical release poster Directed by Jacques Audiard Produced by Rosa Attab Pascal Caucheteux Michael De Luca Allison Dickey John C. Reilly Screenplay by Jacques Audiard Thomas Bidegain Based on The Sisters Brothers by Patrick deWitt Starring John C. Reilly Joaquin Phoenix Jake Gyllenhaal Riz Ahmed Rutger Hauer Music by Alexandre Desplat Cinematography Benoît Debie Edited by Jonathan Amos Juliette Welfling Paul Machliss Production company Why Not Productions Annapurna Pictures Page 114 Productions Distributed by Annapurna Pictures Release date 2 September 2018 (2018-09-02) (Venice) 21 September 2018 (2018-09-21) (United States) Running time 121 minutes[1] Country United States France Language English