In 2011, Khaketla was one of seven women ministers in the Cabinet, alongside: Mannete Ramali, Maphoka Motoboli, Mathabiso Lepono, Mphu Keneileo Ramatlapeng, Mpeo Mahase-Moiloa and Pontso Suzan Matumelo Sekatle.[6] On 30 March 2015 she was appointed Minister of Finance.