No. of children Mother/couple Notes 69 Mrs. and Mr. Vassilyev (1st wife).[1] Vassilyev and his first wife hold the record for the most children a couple has parented. She gave birth to a total of 69 children – sixteen pairs of twins, seven sets of triplets and four sets of quadruplets – between 1725 and 1765, in a total of 27 births. 67 of the 69 children born were said to have survived infancy.