Biffle regressed in 2006, missing the Chase for the Cup despite winning twice at Darlington Raceway and Homestead-Miami Speedway (both of which were tracks at which he had also won in the previous season). He finished 13th in the standings, third-best of the drivers not to qualify for the Chase. He also missed the Chase the following year, in a season marred by the No. 16 team's new primary sponsor Ameriquest Mortgage suffering financial difficulty and having to sell off a number of its race sponsorships.