Mirtazapine in combination with an SSRI, SNRI, or TCA as an augmentation strategy is considered to be relatively safe and is often employed therapeutically,[1] with a combination of venlafaxine and mirtazapine, sometimes referred to as "California rocket fuel".[59][60] Several case reports document serotonin syndrome induced by the combination of mirtazapine with other agents (olanzapine,[61] quetiapine,[62] tramadol and venlafaxine[63]).