When Pizarro left Cuzco with Almagro and Manco Inca, for Jauja in pursuit of Quizquiz, Francisco left his younger brothers Gonzalo Pizarro and Juan Pizarro as regidores, and a ninety-man garrison in the city. The Pizarro brothers so mistreated Manco Inca that he ultimately tried to escape in 1535. He failed, was captured and imprisoned.