Plazomicin has been reported to demonstrate in vitro synergistic activity when combined with daptomycin or ceftobiprole versus methicillin-resistant Staphylococcus aureus, vancomycin-resistant S. aureus and against Pseudomonas aeruginosa when combined with cefepime, doripenem, imipenem or piperacillin/tazobactam.[1] It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii.[10] Plazomicin was found to be noninferior to meropenem.[11][12]