They started off the game with a 9-play, 70-yard drive in which Josh Allen rushed twice for 41 yards and completed 4/5 passes for 24, the last an 8-yard touchdown pass to tight end Dawson Knox. New England responded with a drive to the Bills 34, but defensive back Micah Hyde ended the drive by intercepting Mac Jones' pass in the end zone. Then Allen rushed for 6 yards and completed 5/7 passes for 62 yards, finishing the possession with an 11-yard scoring pass to Knox that gave Buffalo a 14–0 lead on the last play of the first quarter.