In prostate cancers containing ETS-gene fusions (such as TMPRSS2-ERG), chromoplexy breakpoints are generally clustered within actively transcribed DNA and open chromatin. While chromothripsis is often associated with loss of DNA (“deletions”), regions of lost DNA may be smaller and less common in chromoplexy.[2] However, “deletion bridges” may be seen in chromoplexy that represent lost DNA at the fusion junctions of rearrangements. In at least some instances of prostate cancer, chromoplexy can occur in multiple subsequent rounds.[1] In contrast, multiple independent chromothripsis events have not been identified in single tumors.