Findings by King and colleagues, which are largely corroborated by a recent meta-analysis, suggest that the Differentiator Model best characterizes heavy drinkers at risk for developing alcohol use disorder.[1][2] Specifically, over the course of several studies, heavy drinkers reported greater positive SR on the ascending limb of intoxication and lower negative SR on the descending limb, in relation to light drinkers.[11] Increased sensitivity to alcohol's stimulating effects along rising BAC and muted sensitivity to alcohol's sedative effects along waning BAC were subsequently predictive of future increases in binge drinking, blackouts, hangovers and alcohol use disorder symptomatology.[2][12][13]