Lurasidone is contraindicated in individuals who are taking strong inhibitors of the liver enzyme CYP3A4 (ketoconazole, clarithromycin, ritonavir, levodropropizine, etc.) or inducers (carbamazepine, St. John's wort, phenytoin, rifampicin etc.).[20] The use of lurasidone in pregnant women has not been studied and is not recommended; in animal studies, no risks have been found.[21] Excretion in breast milk is also unknown; lurasidone is not recommended for breastfeeding women.[22] In the United States it is not indicated for use in children.[23]