It is unknown whether Ruysch was a member of the Amsterdam Guild of Saint Luke, but early signed works by her in the 1680s show the influence of Otto Marseus van Schrieck. By 1699 she and her family had moved to The Hague, where she was offered membership in the Confrerie Pictura as their first female member.[1] In 1701 she and her husband became members of The Hague Painter's Guild.