Systematic ICM analysis of biological systems reveals the supramolecular segregation law that describes the principle of order of large, hierarchically organized biomolecular networks in situ (toponome).[6] The ICM is the core technology for the systematic mapping of the complete protein network code in tissues (human toponome project).[2] The original ICM method [1] includes any modification of the bleaching step. Corresponding modifications have been reported for antibody retrieval [7] and chemical dye-quenching [8] debated recently.[9][10] The Toponome Imaging Systems (TIS) and Multi-Epitope-Ligand cartographs (MELC) represent different stages of the ICM technological development. Imaging Cycler Microscopy received the American ISAC best paper award in 2008 for the three symbol code of organized proteomes.[11]