Calls to US poison control centers related to e-cigarette exposures involved inhalations, eye exposures, skin exposures, and ingestion, in both adults and young children.[16] Minor, moderate, and serious adverse effects involved adults and young children.[2] Minor effects correlated with e-cigarette liquid poisoning were tachycardia, tremor, chest pain and hypertension.[17] More serious effects were bradycardia, hypotension, nausea, respiratory paralysis, atrial fibrillation and dyspnea.[17] The exact correlation is not fully known between these effects and e-cigarettes.[17] 58% of e-cigarette calls to US poison control centers were related to children 5 years old or less.[15] E-cigarette calls had a greater chance to report an adverse effect and a greater chance to report a moderate or major adverse effect than traditional cigarette calls.[15] Most of the e-cigarette calls were a minor effect.[15]