Mease was born on August 11, 1771, the son of Philadelphians John and Esther (Miller) Mease. After receiving his bachelor's degree from the University of Pennsylvania in 1787, he continued in medical school there, receiving his M.D. in 1792. Early in his medical career, Mease published several articles, and he served as a surgeon for nine months during the War of 1812.[3]