The first HPV vaccine became available in 2006. As of 2014, 58 countries include it in their routine vaccinations, at least for girls.[1] They are on the World Health Organization's List of Essential Medicines, the most important medication recommended for a basic health system.[7] The wholesale cost is about 47 USD a dose as of 2014.[8] In the United States it cost more than 200 USD.[9] Vaccination may be cost effective in the developing world.[10]