Inside cells, amifostine detoxifies reactive metabolites of platinum and alkylating agents, as well as scavenges free radicals.[1][2] Other possible effects include accelerated DNA repair,[1] induction of cellular hypoxia,[1] inhibition of apoptosis,[2] alteration of gene expression[2] and modification of enzyme activity.[2] Amifostine is believed to radioprotect normal tissue via Warburg-type effects.[3]