The river basin of the Mezen comprises vast areas in the east and north-east of Arkhangelsk Oblast and in the west of the Komi Republic. The town of Mezen, the urban type settlements of Usogorsk and Kamenka, as well as the administrative center of Udorsky District, the selo of Koslan all are located on the banks of the Mezen. The administrative center of Leshukonsky District, the selo of Leshukonskoye, is located on the Vashka River several kilometers upstream from the confluence of the Vashka and the Mezen and is connected with the right bank of the Mezen by a ferry crossing.