Tricyclic anti-depressant overdose Synonyms TCA poisoning, TCA overdose, TCA toxicity Chemical structure of the tricyclic antidepressant amitriptyline Specialty Emergency medicine Symptoms Elevated body temperature, large pupils, irregular heart beat, seizures[1] Usual onset Within 6 hours[2] Causes Accidental or purposeful[2][3] Treatment Supportive, sodium bicarbonate, lipid emulsion[2] Frequency Relatively common[1][4] Deaths 270 per year (UK)[1]