Oprah Winfrey as Mrs. Which Reese Witherspoon as Mrs. Whatsit Mindy Kaling as Mrs. Who Storm Reid as Meg Murry, a gifted young girl Levi Miller as Calvin O'Keefe, Meg's classmate and friend Deric McCabe as Charles Wallace Murry, Meg's prodigious adoptive 6-year-old brother Chris Pine as Dr. Alexander Murry, Meg and Charles Wallace's long-lost father Zach Galifianakis as The Happy Medium Michael Peña as Red[10] David Oyelowo as the IT, Red's true diabolical form[10] Gugu Mbatha-Raw as Dr. Kate Murry, Meg and Charles Wallace's mother André Holland as Principal James Jenkins[10] Rowan Blanchard as Veronica Kiley[10] Bellamy Young as Camazotz Woman[10] Conrad Roberts as Elegant Man[10] Yvette Cason as a teacher[10] Will McCormack as another teacher[10] Daniel MacPherson as Calvin's Father[10]