Physicists and chemists are apt to be more interested in changes in entropy as a system spontaneously evolves away from its initial conditions, in accordance with the second law of thermodynamics, rather than an unchanging probability distribution. As the minuteness of Boltzmann's constant kB indicates, the changes in S / kB for even tiny amounts of substances in chemical and physical processes represent amounts of entropy that are extremely large compared to anything in data compression or signal processing. In classical thermodynamics, entropy is defined in terms of macroscopic measurements and makes no reference to any probability distribution, which is central to the definition of information entropy.