USC consists of five campuses in different areas of Metro Cebu – the Downtown Campus (formerly the Main Campus) along P. del Rosario St.; the Talamban Campus (TC) along Gov. Manuel Cuenco Ave., Brgy. Talamban; the North Campus (formerly the Boys High Campus) along Gen. Maxilom Ave; the South Campus (formerly the Girls High) along corners J. Alcantara St. (P. del Rosario Ext.) and V. Rama Avenue; and the newest is the Montessori Academy along F. Sotto Drive (at the back of USC North Campus).