Currently there are also four other proteins that are affected by the deletion of TFAP2A gene as well. One is L249P, this protein changes to cause a conformational space change with a substituted proline. Furthermore, a change in the R254W and R255G proteins results in a replacement of a charged polar side chain by a nonpolar side chain,[clarification needed] and lastly, an alteration in the G262E protein results in a nonpolar side chain being replaced by a charged polar side chain.[1]