Via its weak progestogenic and androgenic activity, through activation of the PR and AR in the pituitary gland, danazol produces antigonadotropic effects.[18] Although its does not significantly affect basal luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in premenopausal women (and hence does not profoundly suppress gonadotropin or sex hormone levels like other, stronger antigonadotropins do),[26] the drug prevents the mid-cycle surge in the levels of these hormones during the menstrual cycle.[9][15][20][27][28] By doing this, it suppresses increases in estrogen and progesterone levels at this time and prevents ovulation.[15][20][27][28]