On 31 July 2021 Macclesfield played their first competitive match, a 1–0 win at home against Burscough in the NWCFL Premier Division played in front of a restricted capacity sell-out crowd of 2,018; Leon Arnasalam scored the only goal.[12] The club's first away match was on 3 August, a 4–4 draw at Winsford United, also in the NWCFL Premier Division, with Tom Clare scoring all four Macclesfield goals.[13] On 7 August Macclesfield played their first FA Cup match, beating Burscough 4–0 in the Extra Preliminary Round, but were then knocked out of the FA Cup in the Preliminary Round losing 6–4 at Squires Gate.[14]