Amino acid N-carboxyanhydrides, also called Leuchs' anhydrides, are reactive derivatives of amino acids. They are used in the field of biomaterials for their applications in drug delivery, gene therapy, antibiotics, and tissue engineering.[1][2] Typically, these compounds are derived from amino acids by treatment with triphosgene, phosgene, PCl5, and other halogenating reagents. NCAs can be used to prepare polypeptides through ring-opening polymerization, a practical approach for large-scale production of polypeptides where sequence specificity is less important than bulk physical properties.[1][2] These compounds find application in biochemistry, biomedical engineering, and nanotechnology due to their propensity for polymerization upon treatment with nucleophiles, hexamethyldisilazane, and transition metals to create polypeptides.[3][4][5][6] Evidence suggests that these compounds might be involved in abiogenesis.[3]