After waiting impatiently for the end of his regency by the Egyptian Pharaoh Hatshepsut, he immediately responded to a revolt of local rulers near Kadesh in the vicinity of modern-day Syria. As Egyptian buffer provinces in the land of the Amurru along the border with the Hittites attempted to change their vassalage, Thutmose III dealt with the threat personally. The Canaanites are thought to have been allied with the Mitanni and Amurru from the region of the two rivers between the headwaters of the Orontes and the Jordan.