Bone regeneration takes place during fracture healing and bone remodeling that takes place throughout life. Bone healing also tends to occur without scar formation and with full functional capacities being restored. Growth factors, such as bone morphogenic proteins (BMPs), are important in inducing the differentiation of MSCs during bone regeneration.[30] Bone regeneration in adults appears to mimic bone development during embryogenesis, except for the requirement of inflammation to initiate the regenerative process.[2] Another difference between bone development and regeneration is the decreased number of osteoprogenitor cells during regeneration.