John C. Reilly as Eli Sisters, hitman, Charlie's brother Aldo Maland as Young Eli Sisters Joaquin Phoenix as Charlie Sisters, hitman, Eli's brother Theo Exarchopoulos as Young Charlie Sisters Jake Gyllenhaal as John Morris, a detective assigned to bring Warm to the Sisters Brothers Riz Ahmed as Hermann Kermit Warm, a chemist who has concocted a formula for finding gold Rutger Hauer as Commodore, the Sisters Brothers' boss Carol Kane as Mrs. Sisters, the mother of the Sisters Brothers Rebecca Root as Mayfield Ian Reddington as The Father Richard Brake as Rex Allison Tolman as Girl Mayfield Saloon