Chaga has been used as a folk remedy in Russia and Siberia since the 16th century.[75] According to the Memorial Sloan–Kettering Cancer Center, "no clinical trials have been conducted to assess chaga's safety and efficacy for disease prevention or for the treatment of cancer, cardiovascular disease, or diabetes". They caution that the mushroom extract can interact with other drugs.[76] Juice Plus – a branded line of dietary supplements containing concentrated fruit and vegetable juice extract.