anti-glucocorticoids psychoactive drugs that up-regulate the GRII glucocorticoid receptor:[8] tricyclic antidepressants: Desipramine,[9][10] Imipramine,[9] and Amitriptyline[10] (SSRIs do not [10][11]) serotonin antagonists: Ketanserin[9] mood stabilizers: Lithium[9] corticotropin-releasing hormone (CRH) antagonists glutamate antagonists dehydroepiandrosterone (DHEA) small molecule brain-derived neurotrophic factor (BDNF) analogs stress reduction therapies and exercise.