Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye, and affects roughly 1.2 to 3 million people each year.[1] Acanthamoeba are protozoa found nearly ubiquitously in soil and water, and can cause infections of the skin, eyes, and central nervous system.[2] Infection of the cornea by Acanthamoeba is difficult to treat with conventional medications, and Acanthamoeba keratitis (AK) may cause permanent visual impairment or blindness, due to damage to the clear portion of the front of the eye (called the cornea) or through damage to other structures important to vision.[3][4] Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK) has tested effects of diverse drugs and biocides in AK.[5]