All matches were initially scheduled to be played between 15 and 23 April 2021. One match involving two teams from the Egyptian Second Division was moved to 8 March 2021 to avoid scheduling conflicts, while unconfirmed matches (involving winning teams from Round of 32 fixtures featuring Al Ahly, Pyramids and Zamalek) were postponed to a later date. This round includes two teams from the Egyptian Second Division, Coca-Cola and Petrojet, the lowest ranking sides left in the competition.