Chiusa di Pesio is located at the beginning of the Pesio Valley (its altitude ranges from 575 metres of the main town up to over 2,600 metres of the highest peaks). The main hamlets are San Bartolomeo and Vigna, located in the highest part of the valley, and Combe, Santa Maria Rocca and Abrau which are located more in the plain. Pesio River crosses the whole valley and its spring is called "Pis" (at 1,500 meters above sea level).