There are no records of influenza affecting the New World in 1510,[1] even though numerous other European powers like France, England, and Portugal were sending their first fleets of ships to the New World after Spain. Influenza had previously afflicted the Isle of Santo Domingo (now Hispaniola) in 1493.[40] Amerindian populations sharp decline due to Spanish-imported diseases in these 1490s and early 1500s is however documented, most notably due to smallpox.