Philomelion was probably a Pergamene foundation on the great Graeco-Roman Highway from Ephesus to the east, and to its townsmen the Smyrniotes wrote the letter that describes the martyrdom of Polycarp. Cicero, on his way to Cilicia, dated some of his extant correspondence there; and the place played a considerable part in the frontier wars between the Byzantine emperors and the Sultanate of Rum.