DHA has been reported to induce an increased tolerance for pain without binding to opioid receptors.[1] Researchers have hypothesized that stimulation of FFA1 by DHA could accelerate the release of endorphins, which is how DHA could induce an increased tolerance to pain.[11] DHA binds to FFA1, which could activate a signaling cascade that leads to Ca2+ influx, which then leads to accelerated endorphin release and novel pain control.[11] Again, additional research must be done to fully understand the mechanism and to prove these hypotheses, but the implications could provide additional targets for pain control in individuals.