In September 2016, Mandhana was signed up for a one-year deal with Brisbane Heat for the Women's Big Bash League (WBBL), and along with Harmanpreet Kaur, became one of the first two Indians to be signed up for the League.[16] Playing against Melbourne Renegades in January 2017, she fell awkwardly while fielding after bowling the final ball of her over hurting her knee. She was ruled out of the rest of the tournament which she ended having scored 89 runs in 12 innings.[17][18]