On 23 February 2017, as a substitute replacing Kostas Manolas in the 46th minute of a 1–0 home defeat against Villareal in the round of 32 of the UEFA Europa League, he was sent off with a double yellow card in the 81st minute.[15] On 30 April he was sent off with a red card in the 93rd minute in Derby della Capitale against Lazio in a 3–1 home defeat.[16] Rüdiger finished his second season at Roma with 35 appearances and 4 assists.[3]