The region borders Borkou Region to the north, Wadi Fira Region and Ouaddaï Region to the east, Sila Region to the south-east, Guéra Region to the south, Hadjer-Lamis Region to the south-west, and Bahr el Gazel Region to the west. The terrain is generally savannah grassland, merging into the Sahara Desert in the sparsely populated north of the region. Lake Fitri is located in the south-west of the region.