PMID 2898324. Cite journal Year of publication 1988 Title Orthomolecular therapy: its history and applicability to psychiatric disorders Journal Child Psychiatry Hum Dev Volume 18 Issue 3 Pages 133–50 DOI 10.1007/BF00709727 PMID 2898324 ↑ Ames BN, Elson-Schwab I, Silver EA (April 2002). "High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms".