Support for the Differentiator Model is mixed, perhaps reflecting the paucity of studies designed to test the model itself or record SR over both limbs of intoxication.[1][2] Both oral and intravenous alcohol administration studies reported that FH+ subjects experienced elevated sensitivity to stimulating effects of alcohol along rising BAC, without the corresponding attenuation of sedative effects as BAC fell.[3] A study using an intravenous alcohol clamping method (participants were titrated to a BAC of .06 g/dl whereupon alcohol was infused to maintain a stable BAC for the duration of the study) reported that FH+ subjects experienced heightened stimulation on the ascending limb of intoxication, consistent with the Differentiator Model.[10] However, FH+ subjects reported decreased stimulation during clamping, indicative of acute tolerance.