FASN Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XKT, 2CG5, 2JFD, 2JFK, 2PX6, 3HHD, 3TJM, 4PIV, 4W82, 4W9N, 4Z49, 5C37 Identifiers Aliases FASN, fatty acid synthase, Fasn, A630082H08Rik, FAS, OA-519, SDR27X1, Fatty acid synthase External IDs MGI: 95485 HomoloGene: 55800 GeneCards: FASN Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,078,333 bp[1] End 82,098,332 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 84.56 cM Start 120,805,846 bp[2] End 120,824,547 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • transferase activity • enoyl-[acyl-carrier-protein reductase (NADPH, A-specific) activity] • 3-hydroxypalmitoyl-[acyl-carrier-protein dehydratase activity] • 3-hydroxyoctanoyl-[acyl-carrier-protein dehydratase activity] • protein homodimerization activity • catalytic activity • [acyl-carrier-protein S-acetyltransferase activity] • hydrolase activity, acting on ester bonds • [acyl-carrier-protein S-malonyltransferase activity] • 3-hydroxyacyl-[acyl-carrier-protein dehydratase activity] • fatty acid synthase activity • myristoyl-[acyl-carrier-protein hydrolase activity] • enoyl-[acyl-carrier-protein reductase (NADPH, B-specific) activity] • protein binding • 3-oxoacyl-[acyl-carrier-protein reductase (NADPH) activity] • drug binding • NADPH binding • lyase activity • identical protein binding • oleoyl-[acyl-carrier-protein hydrolase activity] • oxidoreductase activity • 3-oxoacyl-[acyl-carrier-protein synthase activity] • acyl-[acyl-carrier-protein hydrolase activity] • hydrolase activity • palmitoyl-[acyl-carrier-protein hydrolase activity] • phosphopantetheine binding • 3-oxo-pimeloyl-[acp methyl ester reductase activity] • RNA binding • cadherin binding • 3-oxo-glutaryl-[acp methyl ester reductase activity] Cellular component • Golgi apparatus • membrane • melanosome • plasma membrane • glycogen granule • mitochondrion • extracellular exosome • cytoplasm • cytosol Biological process • cellular response to interleukin-4 • pantothenate metabolic process • lipid metabolic process • biosynthetic process • fatty acid metabolic process • mammary gland development • fatty acid biosynthetic process • osteoblast differentiation • acetyl-CoA metabolic process • metabolism • positive regulation of cellular metabolic process • oxidation-reduction process • regulation of cholesterol biosynthetic process • fatty-acyl-CoA biosynthetic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 2194 14104 Ensembl ENSG00000169710 ENSMUSG00000025153 UniProt P49327 P19096 RefSeq (mRNA) NM_004104 NM_007988 RefSeq (protein) NP_004095 NP_032014 Location (UCSC) Chr 17: 82.08 – 82.1 Mb Chr 11: 120.81 – 120.82 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse