Gottlieb Haberlandt first pointed out the possibilities of the culture of isolated tissues, plant tissue culture.[4] He suggested that the potentialities of individual cells via tissue culture and also suggested that the reciprocal influences of tissues on one another could be determined by this method. Since Haberlandt's original assertions methods for tissue and cell culture have been realized, leading to significant discoveries in Biology and Medicine. His original idea presented in 1902 was called totipotentiality: “Theoretically all plant cells are able to give rise to a complete plant.”[5][6][7]