On 8 January 1968, in Dacca, then in East Pakistan, Mufti Mahmud was one of the key leaders of Jamhoori Majlis-e-Amal that opposed Ayub Khan's regime. In the 1970 General Elections, Mufti Mahmud had a landslide victory against Zulfiqar Ali Bhutto in the Dera Ismail Khan constituency.[1]