Hypertension Thromboembolic (both venous and arterial) events Haemorrhagic events (including cerebral haemorrhage) GI perforations and fistula Thyroid function, it is advised that thyroid function is measured initially and then periodically during treatment with axitinib. Stop treatment 24 hours prior to surgery due to potential clotting changes Proteinuria, it is advised that proteinuria is monitored initially and then periodically during therapy Elevated liver enzymes reported, it is advised that AST, ALT and bilirubin are regularly monitored during treatment with axitinib Moderate hepatic impairment requires dose reduction