He was returned to the Senate in 1842, serving until 1848, when he resigned to run for governor, hoping his election would help Zachary Taylor win Kentucky's vote in the 1848 presidential election. Taylor was elected, but Crittenden refused a post in his cabinet, fearing he would be charged with making a "corrupt bargain", as Clay had been in 1825. Following Taylor's death in 1850, Crittenden resigned the governorship and accepted Millard Fillmore's appointment as attorney general.