Theodora Megale Komnene (Greek: Θεοδώρα Μεγάλη Κομνηνή), also known as Despina Khatun (Persian: دسپینا خاتون‎; from the Greek title Despoina and Mongol and Türk title Khatun, both meaning "Lady, princess, queen"), was the daughter of John IV of Trebizond and Bagrationi who married the Aq Qoyunlu ruler Uzun Hasan in 1458. She became the mother of Martha (Halima) who became the mother of first Safavid king, Shah Ismail I.