In human dentistry, the maxillary canine is the tooth located laterally (away from the midline of the face) from both maxillary lateral incisors of the mouth but mesial (toward the midline of the face) from both maxillary first premolars. Both the maxillary and mandibular canines are called the "cornerstone" of the mouth because they are all located three teeth away from the midline, and separate the premolars from the incisors. The location of the canines reflect their dual function as they complement both the premolars and incisors during mastication, commonly known as chewing.