Francisco de Almeida (1505–1509) and Afonso de Albuquerque (1509–1515), who followed da Gama to India, were instrumental in establishing the Império Colonial Português in Asia.[1] By the mid-16th century, the Portuguese managed to curtail the vital trade between Calicut and the Middle East. In the end of the century, Kochi was the dominant seaport in Kerala, having surpassed both Kannur and Calicut.[2] The Portuguese set about breaking the monopoly which Venetians and the Egyptians had so long enjoyed in the trade with Asia. The Egyptians and the Ottoman Turks realised the danger, but internal complications between them gave the Portuguese an opportunity.[60] Ponnani Muhammed Kunjali Marakkar was eventually executed by the combined effects of the Kingdom of Calicut and the Portuguese state in 1600.[4]