Patients with schizophrenia may have some gray matter volume loss in both hemispheres of the brain.[8][non-primary source needed] The most significant losses are typically in the left thalamus and right caudate, and this loss extends into the cerebrum, parahippocampal gyrus, and the hippocampus.[8] There are increases in the temporal and parietal lobes, along with the anterior cerebellum.[8] When patients with schizophrenia are compared to healthy participants, there is a decrease in gray matter volume in prefrontal and temporal regions.[9][non-primary source needed] The only region in which the volume increases for gray matter is within the right cerebellum,[9] an area that contributes to the cognitive, affective, perceptual, and other deficits seen in schizophrenia.[10]