In August 2016, Kamishiraishi made her first stage play appearance in the Tours Musical troupe production of Anne of Green Gables, becoming the youngest actress ever in the troupe to play main character Anne Shirley,[16] which had also been portrayed by Mone the previous year.[17] The next year, she made her feature film debut in Haruta & Chika and became friends with female lead Kanna Hashimoto.[18][19] She also starred in the musical adaptation of Kiki's Delivery Service as main character Kiki,[17] and played the lead character in an original stage sequel of The Girl Who Leapt Through Time.[20]