AIRE Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LRI, 1XWH, 2KE1, 2KFT Identifiers Aliases AIRE, AIRE1, APECED, APS1, APSI, PGA1, autoimmune regulator External IDs OMIM: 607358 MGI: 1338803 HomoloGene: 327 GeneCards: AIRE Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 44,285,838 bp[1] End 44,298,648 bp[1] Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 78,030,022 bp[2] End 78,043,610 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • histone binding • chromatin binding • transcription cofactor activity • translation regulator activity • metal ion binding • protein binding • identical protein binding • transcription regulatory region DNA binding • zinc ion binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • intracellular • nuclear body • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • negative thymic T cell selection • humoral immune response • immune response • regulation of translation • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • peripheral T cell tolerance induction • central tolerance induction to self antigen • chemokine production • positive regulation of transcription, DNA-templated • thymus epithelium morphogenesis • regulation of thymocyte migration Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 326 11634 Ensembl ENSG00000160224 ENSMUSG00000000731 UniProt O43918 Q9Z0E3 RefSeq (mRNA) NM_000383 NM_000658 NM_000659 NM_001271549 NM_001271550 NM_001271551 NM_001271552 NM_001271553 NM_001271554 NM_001271555 NM_001271556 NM_001271557 NM_001271558 NM_001271559 NM_009646 RefSeq (protein) NP_000374 NP_001258478 NP_001258479 NP_001258480 NP_001258481 NP_001258482 NP_001258483 NP_001258484 NP_001258485 NP_001258486 NP_001258487 NP_001258488 NP_033776 Location (UCSC) Chr 21: 44.29 – 44.3 Mb Chr 10: 78.03 – 78.04 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse