Khaketla was appointed as a senator by Prime Minister Pakalitha Mosisili in 2002 and served as Minister of Communications, Science and Technology from 2002 until 2004.[1] At the 2007 election, she lost her seat but was elected to the National Assembly as one of the Lesotho Congress for Democracy members on a party list for proportional representation submitted by the National Independence Party.[4] She served as Minister of Education and Training from 2007 until 2012.