Amitraz (development code BTS27419) is a non-systemic acaricide and insecticide[1] and has also been described as a scabicide. It was first synthesized by the Boots Co. in England in 1969.[2] Amitraz has been found to have an insect repellent effect, works as an insecticide and also as a pesticide synergist.[3] Its effectiveness is traced back on alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.[4] Therefore, it leads to overexcitation and consequently paralysis and death in insects. Because amitraz is less harmful to mammals, amitraz is among many other purposes best known as insecticide against mite- or tick-infestation of dogs.[1] It is also widely used in the beekeeping industry as a control for the Varroa destructor mite, although there are recent reports of resistance (driven by overuse and off label use)reference needed here, questionable statement.