The Jerome Lab run by Dr. Keith Jerome at the Fred Hutchinson Cancer Research Center has looked at using zinc finger nuclease as well as endonuclease to prevent HSV from replicating. Most recently Dr. Jerome and his lab were able to demonstrate cleavage of latent HSV in a living organism, which is vital to disabling the virus.[96] The lab is now looking at ways to better optimize the process, including using CRISPR-Cas9, with several years of work expected before clinical trials are considered.[97]