Genetically modified plants must be safe for the environment and suitable for coexistence with conventional and organic crops. A major hurdle for traditional nuclear genetically modified crops is posed by the potential outcrossing of the transgene via pollen movement. Initially it was thought that, plastid transformation, which yields transplastomic plants in which the pollen does not contain the transgene, not only increases biosafety, but also facilitates the coexistence of genetically modified, conventional and organic agriculture.