Hirano bodies were first described in the CA1 in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC).[1] Hirano bodies (Hb) are found mostly in the neuronal processes in the pyramidal layer in the Sommer’s sector (CA1) of the hippocampus, mostly arising from age related changes in the microfilament system.[2][2] Hirano bodies are often described as rod-shaped, crystal-like, and eosinophilic (pink after staining with haematoxylin and eosin). They are frequently seen in hippocampal pyramidal cells.[3] An experimental model of Hirano body formation has been reported, using a genetically altered strain of the slime mold Dictyostelium discoideum.[6]