SHP-2. SHP-2 has a very similar structure to SHP-1, but unlike SHP-1, SHP-2 is produced in many different cell types - not just blood cells.[40] Humans have two SHP-2 proteins, each made up of 593 and 597 amino acids.[2] The SH2 domains of SHP-2 appear to play an important role in controlling the activity of SHP-2.