VEGF family Type Function VEGF-A Angiogenesis [citation needed] ↑ Migration of endothelial cells ↑ mitosis of endothelial cells ↑ Matrix metalloproteinase activity ↑ αvβ3 activity creation of blood vessel lumen creates fenestrations Chemotactic for macrophages and granulocytes [citation needed] Vasodilation (indirectly by NO release) [citation needed] VEGF-B Embryonic angiogenesis (myocardial tissue, to be specific)[13] VEGF-C Lymphangiogenesis [citation needed] VEGF-D Needed for the development of lymphatic vasculature surrounding lung bronchioles [citation needed] PlGF Important for Vasculogenesis, Also needed for angiogenesis during ischemia, inflammation, wound healing, and cancer. [citation needed]