The combination was approved for medical use in the United States in 1960.[1] It is available as a generic medication and over the counter.[2] In the United States the wholesale cost per is dose is US$0.31.[5] In 2016 it was the 298th most prescribed medication in the United States with more than a million prescriptions.[6] It is sold under the brand name Lomotil among others.[1] The medication is in Schedule V in the United States.[5]