In 1882, Doyle partnered with his former classmate George Turnavine Budd in a medical practice in Plymouth, but their relationship proved difficult, and Doyle soon left to set up an independent practice.[1][27] Arriving in Portsmouth in June 1882, with less than £10 (£1100 in 2019[28]) to his name, he set up a medical practice at 1 Bush Villas in Elm Grove, Southsea.[29] The practice was not successful.