Cross and Odenkirk introduced most episodes as semi-fictionalized versions of themselves, before transitioning to a mixture of live sketches and pre-taped segments. The show featured a number of alternative comedians as both cast members and writers, including Sarah Silverman, Paul F. Tompkins, Jack Black, Tom Kenny, Mary Lynn Rajskub, Brian Posehn, Jerry Minor, Scott Aukerman, and Dino Stamatopoulos.