Water, being the most polar-solvent listed above, stabilizes the ionized species to a greater extent than does DMSO or Acetonitrile. Ionization - and, thus, acidity - would be greatest in water and lesser in DMSO and Acetonitrile, as seen in the table below, which shows pKa values at 25 °C for acetonitrile (ACN)[3][4][5] and dimethyl sulfoxide (DMSO)[6] and water.