A meta-analysis published in 2001 found a small but significant increased risk for men drinking more than 50 g/day of alcohol, with a slightly higher risk for men consuming more than 100 g/day.[86] Since that analysis, cohort studies in America have found increased risks for men drinking moderate amounts of spirits, and for ‘binge drinkers,[87] but moderate consumption of beer or wine has not been linked to an increased risk.[88][89][90]