This suggests that specific brain regions are specifically engaged in the post-processing of sequential information. This is further supported by the fact that regional CBF (rCBF) during post-training REM sleep are modulated by the level of high-order, but not low-order learning obtained prior to sleep. Therefore, brain regions that take part in a learning process are modulated by both the sequential structure of the learned material (increased activation in cuneus), and the amount of high-order learning (rCBF).[30]