PICCs can be used for intravenous delivery of total parenteral nutrition (TPN), chemotherapy, antibiotics or other medications, and can also be used for blood sampling if the lumen is 4 French or larger in size (Arrow and Bard manufacturers guidelines). To maintain patency, PICC management should include regular flushing with normal saline and "locking" with Heparin or normal saline when not in use. The type of locking procedure depends on the type of PICC and bung; Groshong PICCs have a three-way valve at the tip so the use of a heparin lock is not necessary, and there are no clamps on the external length.