Ho started her career as an engineer with the Ministry of Defence of Singapore in 1976.[5] In 1983, she became the Director of Defence Materiel Organisation, the defence procurement agency of the Ministry, and concurrently held the position of Deputy Director of Defence Science Organisation. She joined Singapore Technologies in 1987 as Deputy Director of Engineering, and took on various senior responsibilities before becoming its President and Chief Executive Officer in 1997.[2] She is credited with repositioning and growing the group in the five years that she led it.