In December 2020, Piastri announced that he would continue with Prema into Formula 2, replacing the departing Mick Schumacher and partnering Ferrari Driver Academy member Robert Shwartzman for the 2021 season.[33] Piastri finished fifth in his debut race. In the second race, Piastri started from sixth and made up places before overtaking fellow Alpine junior Zhou Guanyu on the final lap to take the lead, claiming his first Formula 2 race win.