Research in the 1960s and 1970s produced the first problem-solving program, or expert system, known as Dendral.[7] While it was designed for applications in organic chemistry, it provided the basis for the subsequent system MYCIN,[8] considered one of the most significant early uses of artificial intelligence in medicine.[8][9] MYCIN and other systems such as INTERNIST-1 and CASNET did not achieve routine use by practitioners, however.[10]