Second, this reduction may also impair the secretion of antimicrobial proteins and peptides.[5] Considering presence of many proteins and peptides with established antiviral properties in saliva, some of which can potentially inhibit virus replication especially coronavirus, it gives the impression that the protective effect of these salivary proteins against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be the same.[6] Therefore, hyposalivation could be a potential risk factor for acute respiratory infection. It may expose patients at high risk of getting coronavirus disease (COVID-19). However, further investigations are crucial to prove this hypothesis.[6]