Osmia calaminthae is very poorly known and its conservation status is not currently documented by the United States Fish and Wildlife Service.[1][3][4] It is listed as a "species of greatest conservation need" by the Florida State Wildlife Action Plan,[3][4] and as of 2019 it has been listed as Critically Imperiled by NatureServe.[4] In 2015, a petition was filed to the US Fish and Wildlife Service to evaluate the conservation status for the bee, and its status is now under review.[3][4][5][6] The bee was described in 2011, and its habitat studied in 2016,[7] but its continued existence was unknown until it was rediscovered in March 2020.[3][4] Most of the known habitat for the bee is not protected and is subject to development.