At low concentrations (5-10%), as found in many over-the-counter products, glycolic acid (GA) reduces cell adhesion in the epidermis and promotes exfoliation. Low concentration makes possible daily application as a monotherapy or as part of a broader skin care management for such conditions as acne, photo-damage, wrinkling as well as melasma.[13][14] Care should be taken to avoid irritation to avoid the worsening of melasma or other pigmentary problems.