The vaccine has proven to be safe as far as is known there have been no side effects or other documented issues. The vaccine is administered locally to the infected areas and also given in the arm if the infection is mild. In a study it has been suggested that an immunogenic peptide pool containing epitopes that can be effective against all the high-risk HPV strains circulating globally and 14 conserved immunogenic peptide fragments from 4 early proteins (E1, E2, E6 and E7) of 16 high-risk HPV types providing CD8+ responses.[140][141][142][143][144]