In 2007, Dr. John Sotos proposed that Lincoln had multiple endocrine neoplasia type 2B (MEN2B).[44] This hypothesis suggests Lincoln had all the major features of the disease: a marfanoid body shape, large, bumpy lips, constipation, hypotonia, a history compatible with cancer—to which Sotos ascribes the death of Lincoln's sons Eddie, Willie, and Tad, and probably his mother. The mole on Lincoln's right cheek, the asymmetry of his face, his large jaw, his drooping eyelid, and pseudodepression are also suggested as manifestations of MEN2B.