Lactucin and lactucopicrin were found to have analgesic effects comparable to those of ibuprofen, and sedative activity in measurements of spontaneous movements of the mice.[1] Some effects have also been credited to a trace of hyoscyamine in Lactuca virosa, but the alkaloid was undetectable in standard lactucarium.[2] A crude extract of the seeds was shown to have analgesic and anti-inflammatory effects in standard formalin and carrageenan tests of laboratory rats.