Dr. Mease's published contributions to medical knowledge, however, were less significant than his contributions to several other fields. In addition to several medical works, Mease edited the well-received Domestic Encyclopedia (1803–04) and the two volume Archives of useful knowledge (1811–12), but he remains best known for this seminar 372-page volume, "The Picture of Philadelphia", and his 1807 Geological Account of the United States, which was among the earliest geological treatises by an American.