High ESR/Low CRP[4] Low ESR/High CRP[4] Systemic lupus erythematosis Bone and joint infections Ischemic stroke Waldenstrom's macroglobulinemia Multiple myeloma IgG4 related disease Renal insufficiency Low serum albumin Urinary tract, GI, lung and bloodstream infections Myocardial infarction Venous thromboembolic disease Rheumatoid arthritis Low serum albumin