Information processing and information flow occur in the course of an organism's development and throughout its lifespan.[2] The essence of computation is information processing, and the essence of biological information processing is control of the molecular events inside a cell.[3] Genome informatics introduces computational techniques and applies them to derive information from genome sequences.[4] Genome informatics includes methods to analyze DNA sequence information and to predict protein sequence and structure.[4] Methods of studying a large genomic data include variant-calling, transcriptomic analysis, and variant interpretation.[5] Genome informatics can analyze DNA sequence information and to predict protein sequence and structure.[4] Genome informatics dealing with[6] microbial and metagenomics, sequencing algorithms, variant discovery and genome assembly, evolution, complex traits and phylogenetics, personal and medical genomics, transcriptomics, genome structure and function.[6] Genoinformatics refers to genome and chromosome dynamics, quantitative biology and modeling, molecular and cellular pathologies.[7] Genome informatics also includes the field of genome design.