Given inherent heterogeneous nature of any given disease (i.e., the unique disease principle[2]), a single disease entity may be treated as disease subtypes.[3] This framework is well conceptualized in the interdisciplinary field of molecular pathological epidemiology (MPE).[4][5] Characterize the events as to epidemiological factors Predisposing factors Non-environmental factors that increase the likelihood of getting a disease. Genetic history, age, and gender are examples. Enabling/disabling factors Factors relating to the environment that either increase or decrease the likelihood of disease.