Alcohol has been used as an antiseptic at least as early as 1363 with evidence to support its use becoming available in the late 1800s.[10] Alcohol-based hand sanitizer has been commonly used in Europe since at least the 1980s.[11] The alcohol-based version is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[12] The wholesale cost in the developing world is about 1.40 to 3.70 USD per liter bottle.[13][5]