Transcytosis has been shown to be critical to the entry of Cronobacter sakazakii across the intestinal epithelium as well as the blood–brain barrier.[15] Listeria monocytogenes has been shown to enter the intestinal lumen via transcytosis across goblet cells.[16] Shiga toxin secreted by enterohemorrhagic E. coli has been shown to be transcytosed into the intestinal lumen.[17] From these examples, it can be said that transcytosis is vital to the process of pathogenesis for a variety of infectious agents.