Zeke and Luther was set in the northern part of Gilroy, California, specifically in the fictional area of Pacific Terrace, which is stated frequently throughout the series. Gilroy was also mentioned occasionally in the Disney Channel series Even Stevens, which was also created by Zeke and Luther co-creator Matt Dearborn. The episode "Bros Go Pro" was made available to download for free on iTunes in the beginning of June, two weeks before the show's television premiere.