By the time Ruysch was eighteen she was producing and selling independently signed works.[2] She would also have known and consorted with the flower painters Jan and Maria Moninckx, Alida Withoos, and Johanna Helena Herolt-Graff, who all were about her age and who worked for the hortus owner Agnes Block and who, like her father, also worked with the plant collectors Jan and Caspar Commelin.