When BR binds to the BRI1:BAK1 complex, BKI1 is released, and a phosphorylation cascade is triggered which results in the de-activation of another kinase, brassinosteroid insensitive 2 (BIN2). BIN2 and its close homologues inhibit several transcription factors. The inhibition of BIN2 by BR releases these transcription factors to bind to DNA and to enact certain developmental pathways.[16]