On mid-September, Jorge Martín, the Moto2 rider has missed both Misano rounds, becoming the first rider in all classes who has tested positive for virus.[79] In the second Misano round he has replaced by Mattia Pasini. On mid-October, Valentino Rossi has missed both Aragon rounds due to tested positive for the SARS-CoV-2 virus, becoming the first premier class rider who has tested positive for virus.[80] Their team has decided not to field a replacement for Rossi before Teruel round, making the team has decided to line up only his teammate, Maverick Viñales.[81] As Rossi missed the race (along with defending champion Marc Márquez who was absent since Andalusian Grand Prix due to his crash on the previous round), the first Aragon race marked the first time since 1999 at Rio de Janeiro when no current or former premier class Champion will line up on the grid.[82] On Moto3 class in the same venue, Tony Arbolino, despite testing negative for COVID-19, was forced to miss the Aragon Grand Prix as he had come into close contact with an infected passenger on his flight after the French Grand Prix and was required to self-isolate as a result. He was not replaced for that event and was back to racing at the Teruel Grand Prix.[83] On the early November, three days before the European Grand Prix at Valencia, Tech3 rider Iker Lecuona was forced to sit out of the race, due to Andorran quarantine rules for close contact with individuals who tested positive for the SARS-CoV-2 virus.