The Roman Plague of 590 was an epidemic of plague that affected the city of Rome in the year 590.[1] Probably bubonic plague, it was part of the first plague pandemic that followed the great plague of Justinian, which began in the 540s and may have killed more than 100 million Europeans[2] before spreading to other parts of the world[3] and which lasted until the end of Late Antiquity. The plague was described by the bishop and chronicler Gregory of Tours and later chronicler Paul the Deacon.[1]