Moreover, gain of chromosome 1q25 has been found to independent prognostic value for recurrence-free and overall survival.[4] Loss of 22q has been found in both sporadic and familial cases, supporting the presence of a tumor suppressor gene at this location.[17][18] However, loss of 22q is more common in the adult form than pediatric cases.[14][18][19] As NF2 is located on 22q12.2, it was hypothesized to be involved in the development of ependymoma.