Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts in its native host, the North American rabbit genus Sylvilagus. These horn-like warts may be the original basis for the urban legends of the American antlered rabbit the Jackalope and European Wolpertinger.[18] European domestic rabbits (genus Oryctolagus) can be transiently infected with CRPV in a laboratory setting.