The first season, titled Medici: Masters of Florence, takes place in 1429, the year Giovanni de' Medici, head of the family, died. His son Cosimo de' Medici succeeds him as head of the family bank, the richest bank of Europe at that time, and fights to preserve his power in Florence. The second season, titled Medici: The Magnificent, takes place 35 years later and tells the story of Cosimo's grandson Lorenzo de' Medici (known as the Magnificent).