In 1754 the Jesuits surrendered control of the missions, but the Guaraní led by Sepé Tiaraju, refused to comply with the order to relocate. Efforts by the Spanish army in 1754 to forcefully remove the Guarani from the missions failed. On February 10, 1756, a combined force of 3,000 Spanish and Portuguese soldiers fought the Guaraní at the battle of Caiboaté.[2] It resulted in the death of 1,511 Guaraní, while the Europeans suffered only 4 deaths.