Iron poisoning is an iron overload caused by a large excess of iron intake and usually refers to an acute overload rather than a gradual one. The term has been primarily associated with young children[1] who consumed large quantities of iron supplement pills, which resemble sweets and are widely used, including by pregnant women; approximately 3 grams is lethal for a two-year-old.[2] Targeted packaging restrictions in the US for supplement containers with over 250 mg elemental iron have existed since 1978, and recommendations for unit packaging have reduced the several iron poisoning fatalities per year to almost zero since 1998.[3][4] No known cases of iron poisoning have been identified that are associated with iron mining.[citation needed]