This leads to irregular tissue growth in organs and various other diseases.[1] 83% of COACH syndrome carriers presented with either one or two mutations on the MKS3 gene, and findings suggest this is where most of the symptoms can be accredited. CC2D2A and RPGRIP1L genes may also have some minor contributions, with around 8.7% reporting a mutation on the CC2D2A gene and 4.3% on the RPGRIP1L gene. These three genetic mutations reportedly cover 96% of families suffering from COACH syndrome.[14]