Katherine Heigl as Tully Hart, a famous host of a daytime talk show known as The Girlfriend Hour Ali Skovbye as Young teenage Tully London Robertson as Young Tully 1970 Sarah Chalke as Kate Mularkey, Tully's best friend since they were 14 years old and a housewife who is trying get back in the workforce while going through a divorce Roan Curtis as Young teenage Kate Ben Lawson as Johnny Ryan, Kate's husband and the producer of The Girlfriend Hour Beau Garrett as Cloud, Tully's free-spirited drug-addicted single mother Yael Yurman as Marah Ryan, Kate and Johnny's teenage daughter