Modest cellular immune responses were observed only in HSV seronegative individuals.[15] Monoclonal Antibody Therapy / HDIT101 Heidelberg ImmunoTheraputics GmbH Claudia Kunz, PhD Monoclonal Antibody Therapy / HDIT101 - Clinical Trial #NCT04165122 Phase II HUMANIZED IgG1 KAPPA MONOCLONAL ANTIBODY, Percentage of days with lesion(s) per treatment group, except the lesion episode at randomization, calculated as the number of days with lesion divided by the number of study days after IMP infusion. A lesion is defined as presence of lesion with HSV lesion score 2-7. https://www.clinicaltrialsregister.eu/ctr-search/trial/2019-000880-26/DE UB-621 United BioPharma N/A UB-621 - Clinical Trial #NCT03595995 Phase II Detailed Description: A Two-Stage, Randomized, Double-Blind, Dose-Ranging, Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 on HSV Shedding in Adults With Recurrent Genital HSV-2 Infection. VC2 Louisiana State University Gus Kousoulas Live-attenuated HSV vaccine with small deletions in UL20 and UL53 Preclinical The VC2 vaccine prevents HSV infection of neuronal axons and establishment of latency in animal models such as mice, guinea pig and rhesus monkeys.[16][17][18] R2 Thyreos LLC[19] Gregory Smith, Gary Pickard, Ekaterina Heldwein Live-attenuated HSV vaccine mutated in R2 coding region of UL37 Preclinical A single-dose vaccine effective in mice and rats against multiple neuroinvasive herpesviruses including HSV.[20] HSV-2 ΔgD-2 Albert Einstein College of Medicine William Jacobs Jr & Betsy Harold Live-attenuated HSV-2 vaccine with US6 (gD) deleted Preclinical Combats HSV-1 & HSV-2 in mice[21] HSV-2 Trivalent Vaccine[22] Perelman School of Medicine at the University of Pennsylvania Harvey Friedman[23] & Sita Awasthi HSV-2 subunit trivalent vaccine (containing gC2, gD2, gE2) Preclinical Reduced shedding to 0.2% in animals[24] G103[25] Immune Design HSV-2 subunit trivalent vaccine (containing gD, pUL19, pUL25) Preclinical Prophylactic immunization completely protected against lethal intravaginal HSV-2 infection in mice[26] GV2207[27] GenVec ?