Pharmacokinetic parameters of Axitinib[1] Bioavailability Tmax Cmax AUC Vd Plasma protein binding Metabolising enzymes t1/2 Excretion routes 58% 2.5-4.1 hr 27.8 ng/mL 265 ng•h/mL 160 L >99% Mostly CYP3A4 and CYP3A5.