In 1914, Margaret married her fellow student Harry Clarke, much to the surprise of their family and acquaintances.[5] The couple moved into a flat at 33 North Frederick Street. They had three children, Michael, David and Ann.[1] Harry's brother, Walter married Margaret's sister Mary in 1915.[6] Clarke became the director of the Harry Clarke Stained Glass Studios following the death of her husband in 1931.[4] Clarke died in Dublin 31 October 1961, and is buried in the Redford cemetery, Greystones, Co. Wicklow.[1] She is commemorated with a blue plaque at her birthplace in Newry.[7]