Cleveland Clinic grew out of the surgical practice of Frank J. Weed, MD, at 16 Church Street on the near west side of Cleveland.[1] Weed died in 1891.[2] The practice was purchased by his two assistants, Frank E. Bunts, MD, and George Washington Crile, MD. In 1892, they brought Crile’s cousin, William E. Lower, MD, into the practice.[3] In 1897, they moved their practice to the Osborn Building on Prospect Avenue in downtown Cleveland.[1][4] Crile, Lower and Bunts all became professors at Cleveland medical schools, and each would be elected president of the Academy of Medicine.[5]