Next-generation sequencing technologies provide enormous throughput but lower accuracies than older sequencing methods. When sequencing a single genome, the intrinsic lower accuracy of these methods is far more than compensated for by the ability to cover the entire genome multiple times in opposite directions from multiple start points, but this capability provides no improvement in accuracy when sequencing a diverse mixture of genomes. The question will be, how can sequencing errors be distinguished from actual diversity in the collected microbial samples?[1]