The earliest known use of venom is medicine dates back to 380 B.C. in ancient Greece.[5] Aristotle's "Historia Animalium", describes how venom can be used in the production of antidotes for the venom.[5] During the height of the Roman empire, there is evidence of venom being added into medicine used to treat smallpox, leprosy, fever, and wounds.[5] Despite this, early uses of venom were primarily involved in the process of making antidotes.