Due to the black-handed tamarin’s small size, they are considered prey by many other animals. Their predators include man, diurnal birds of prey, snakes, and various cat species including margay and ocelot, which are capable arboreal hunters.[15] Because black-handed tamarins have both aerial and terrestrial predators, they utilize any tree or bundled, thick foliage into which they can climb, and they maintain a group sleep system to keep safe while resting at night.[2]