The total synthesis of a number of natural alkaloids – pilocarpine, pilozinin, alkaloids of propane series (tropine, cocaine), arecoline, eserine, emetine, psyhotrine, emataliine, cinchonamine, tubocurarine and other alkaloids of curare (magnolin, magnolamine, dauricine). For this work, Professor N. A. Preobragensky in 1952 was awarded the Stalin Prize of the first degree; The synthesis of physiologically active derivatives of piperidine (anesthetics, analgesics, and other drugs), technology development and industrial development of high-output painkiller "promedol"; Academician A. N. Bashkirov for the first time in the world and the Soviet Union in 1959 has been implemented industrial technology for production of higher aliphatic alcohols on the basis of a synthesis of hydrogen and carbon monoxide (the so-called "oxosynthesis technology"); Development of technology for the production of vitamins A1, B1, B2, E, C and K1; Create rubbers based on new types of caoutchouc, operating at high and low temperatures in harsh operating conditions.