Authors of uDISCO (from “ultimate imaging of solvent-cleared organs“) enhance a shrinkage of tissue, a common bystander effect of dehydration of sample in first step of clearing. They used tert-butanol instead of THF for dehydration and also different solution for imaging, which preserve fluorescence better than DBE. Thank to shrinkage of the tissue, they can observe large samples up to size of whole mouse body.[1] It is worth to mention that uDISCO was highlighted by media worldwide including New York Times,[26] Wall Street Journal,[27] Business Insider,[28] Nature and Science[29] magazines.