The estimated lower limit of a lethal dose of nicotine has been reported as between 30 and 60 mg.[7] Children may become ill following ingestion of one cigarette;[8] ingestion of more than this may cause a child to become severely ill.[5][9] The nicotine in the e-liquid of an electronic cigarette can be hazardous to infants and children, through accidental ingestion or skin contact.[10] In some cases children have become poisoned by topical medicinal creams which contain nicotine.[11]