EXOSC3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6 Identifiers Aliases EXOSC3, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, CGI-102, Exosome component 3 External IDs MGI: 1913612 HomoloGene: 6867 GeneCards: EXOSC3 Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.2 Start 37,766,978 bp[1] End 37,801,437 bp[1] Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,316,613 bp[2] End 45,342,732 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exoribonuclease activity • protein binding • RNA binding Cellular component • transcriptionally active chromatin • cytosol • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • cell nucleus • cytoplasm • exosome (RNase complex) • nucleolus • nucleoplasm Biological process • nuclear polyadenylation-dependent tRNA catabolic process • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • regulation of mRNA stability • polyadenylation-dependent snoRNA 3'-end processing • DNA deamination • nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription • CUT catabolic process • nuclear polyadenylation-dependent rRNA catabolic process • positive regulation of isotype switching • isotype switching • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U4 snRNA 3'-end processing • rRNA processing • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 51010 66362 Ensembl ENSG00000107371 ENSMUSG00000028322 UniProt Q9NQT5 Q7TQK4 RefSeq (mRNA) NM_016042 NM_001002269 NM_025513 NM_001362788 RefSeq (protein) NP_001002269 NP_057126 NP_079789 NP_001349717 Location (UCSC) Chr 9: 37.77 – 37.8 Mb Chr 4: 45.32 – 45.34 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse