However coinfection with malaria and HIV, especially among African women, does not respond well to the current combination therapies.[18] It is more pressing for trichuriasis that the recommended drugs fail to provide positive results.[19] A novel drug tribendimidine, which was approved in China by the CCDC for human use in 2004, has been subjected to clinical trials showing that they are highly effective against major human flukes, ascaris (>90% cure rate) and hookworm (>82%); however with low cure rate for whipworm (<37%).[20]