The disease in the lungs is characterized by enlargement of the tracheobronchial lymph nodes and infiltration of the lungs, sometimes leading to lung lobe consolidation and pleural effusion.[6] Signs and symptoms include cough, loss of appetite, weight loss, anemia, and difficulty breathing.[7] Seizures and rear limb weakness can be seen. Invasion of the bone marrow can cause pancytopenia.[8] Diagnosis requires a biopsy.