Khulusi's work mediated modern European and American developments in scholarship. He extended the academic tradition of comparative literature, publishing Dirasat fi al-Adab al-Muqarin wa al-Mathahib al-Adabia (Studies in Comparative Literature and Western Literary Schools) in 1957, and al-Tarjama al-Tahlilia (Analytical Translation) in the same year. Although concentrating on literary and historical scholarship, Khulusi also published novels, short stories and poetry during this period.