It has been used as a gastric stimulant to test for maximal production of gastric secretion activity.[1] The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome where there is excess acid production, in this case driven by over production of gastrin. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease.[2] It is also used in diagnosis of gastritis in association with a test for secretin activity.