Despite the toxic effects to mammalian cells, mastoparan is also a potential antibiotic template due to its potent antimicrobial activity. In design study performed by Irazazabal and co-workers (2016),[4] it was demonstrated that the inclusion of an isoleucine and an arginine residue at positions 5 and 8 respectively [I5, R8], dramatically reduced the toxicity of mastoparan, turning it into a potentially valuable drug for fighting infectious disease.