Co-infection with FIV, FeLV, and Candidatus Mycoplasma haemominutum is common. Although M. haemofelis infection can cause acute hemolytic anemia in otherwise healthy cats, immunosuppression, including that brought on by retroviral pathogenesis, increases susceptibility to the most severe effects of M. haemofelis infection. In some cases, infected cats may remain asymptomatic carriers until compromising of the immune system permits increased parasitemia and the onset of acute symptoms.