Medicinal plants are widely used in non-industrialized societies, mainly because they are readily available and cheaper than modern medicines. The annual global export value of the thousands of types of plants with suspected medicinal properties was estimated to be US$2.2 billion in 2012.[3] In 2017, the potential global market for botanical extracts and medicines was estimated at several hundred billion dollars.[2] In many countries, there is little regulation of traditional medicine, but the World Health Organization coordinates a network to encourage safe and rational usage. Medicinal plants face both general threats, such as climate change and habitat destruction, and the specific threat of over-collection to meet market demand.[2]