This is especially true in low phenotype chromosomal instability,[2] where the changes are subtle. The number of cell divisions undergone by a cell population should be related to the rate of chromosomal change.[2] A chromosomal instability assay should measure not only whole chromosome change rates, but also the partial chromosomal changes such as deletions, insertions, inversion and amplifications to also take into account segmental aneuploidies.[2] This provides a more accurate determination of the presence of chromosome instability.