Karatsev, who was unseeded and beat four seeded players to reach the final, joined Wayne Ferreira (1995) and Thomas Muster (1997) in this achievement.[4] As a result, he entered the top 30 of the ATP singles rankings for the first time in his career.[5] On 24 April 2021, Karatsev defeated World No. 1 Novak Djokovic on his home court at the Serbia Open for the biggest win of his career.[6] At the 2020 Summer Olympics, he won the silver medal with Elena Vesnina in mixed doubles.[7][8]