Due to the structural complexity of the moenomycins, total synthesis has proved difficult, with only one total synthesis reported so far. Some of the largest challenges include fashioning the glycosidic linkages with stereochemical control and site-specifically decorating the oligosaccharide with pendant functionality. Understanding that the majority of variation within the moenomycin family derives from differences within the oligosaccharide unit, Kahne and lab has designed an efficient and flexible total synthesis of moenomycin A that gives access to analogues as well as other members of the moenomycin family.[9]