It is the parent lineage to the E-Z830 and E-V257 subclades, and defines their common phylogeny. The former is predominantly found in the Horn of Africa and the Middle East, whereas the latter is most frequently observed in North Africa, with its E-M81 subclade observed among the ancient Guanche of the Canary Islands. E-Z827 is also found at lower frequencies in Europe, and in isolated parts of Southeast Africa.