The game centers on Sadler, a Syrian Assassin (a Shia Islamic sect) who is on a journey to kill the Caliph. The intro sequence briefly covers the history of the Middle East from 622 CE, the first year of the Islamic calendar, including a brief description of the Hijra, up until 1104 CE, the year of Sadler's birth. The game then starts in Baghdad, where Sadler rescues Rumi, and follows Sadler to Persia and then Babylon, where he must defend the Euphrates River from pollution by an oil magnate, encounter the Assyrian queen Semiramis and Babylonian goddess Ishtar, and visit the Tower of Babel in search of unicorns, before heading to Alexandria, becoming baptised in a Jewish village, and searching for Ouroboros.