Born and raised in San Juan, Puerto Rico, Residente developed an interest in art, music, and left-wing politics at an early age. He studied art at the Savannah College of Art and Design in Savannah, Georgia, returning to Puerto Rico in 2003 to work on music with his step-brother, Visitante, with whom he formed Calle 13. Early in his career, his sarcastic and self-deprecating lyrical style garnered both praise and controversy.