Kramer and Bertozzi recently described synthesis of mucin mimic glycopolypeptides based on native N-acetylgalactosylated poly(serines) (GalNAc-PS).[19] They described synthesis of controlled molecular weight glycopolypeptides in the massive size range of native mucins and prepared a small library of structures with varied chain lengths and glycosylation densities using NCA polymerization. These glycopolypeptides were found to have physical properties similar to native mucins in that their circular dichroism (CD) spectra indicated a very rigid extended conformation. Atomic force microscopy (AFM) studies of persistence length revealed that native glycosylation indeed results in a rigidification of the peptide backbone and these polymers have a nanorod-like structure