McIntire is well known for having replaced Ward Bond, upon Bond's sudden death in November 1960, as the star of NBC's Wagon Train. He played Christopher Hale, the leader of the wagon train (and successor to Bond's character, Seth Adams) from early 1961 to the series' end in 1965. He also replaced Charles Bickford, upon Bickford's death in 1967, as ranch owner Clay Grainger (brother of Bickford's character) on NBC's The Virginian for four seasons.