DNA mutations of the tumor homing bacteria in the body can lead to problems like extreme infection and failure of therapy as the genes that are expressed will be different and cause the bacteria to become non-functional. Incomplete tumor lysis or colonization by the bacteria can lead to delayed treatment and will necessitate the use of other cancer treatments such as chemotherapy or a combination of more. Delayed or combined treatment causes many effects on the body such as vomiting, nausea, loss of appetite, fatigue, and hair loss.[8]