Kamishiraishi entered the entertainment industry after winning the Toho Cinderella Audition in 2011 and is represented by Toho Entertainment. She made her acting debut in 2012, and has since appeared in films such as Haruta & Chika (2017) and A Forest of Wool and Steel (2018), for which she won a Newcomer of the Year award at the 42nd Japan Academy Film Prize. She has also done voice acting, such as in Mirai (2018) and Pokémon the Movie: Secrets of the Jungle (2020), and appeared in television dramas, including the NHK taiga drama Idaten (2019) and The Files of Young Kindaichi (2022).