He is Executive Vice President, Global Research and Chief Scientific Officer at Vertex Pharmaceuticals.[4] Prior to joining Vertex in 2014, he was at the Broad Institute of Harvard and MIT,[5] and was a Professor of Genetics and Medicine at Harvard Medical School, and in the Department of Biology at Massachusetts Institute of Technology. He was also a faculty member in the Department of Molecular Biology, Center for Human Genetic Research, and the Diabetes Unit, all at Massachusetts General Hospital. He was one of four Founding Core Members of the Broad Institute, and served as the Institute's Deputy Director, Chief Academic Officer, and Director of the Program in Medical and Population Genetics.[6][7]