The gene for sexual differentiation in humans, called the testis determining factor (TDF),[13] is located on the short arm of the Y chromosome.[14][15] The presence or absence of the Y chromosome determines whether the embryo will have testes or ovaries. An abnormal number of sex chromosomes (aneuploidy) may can occur. This includes Turner's syndrome - a single X chromosome is present,[16] Klinefelter's syndrome - two X chromosomes and a Y chromosome are present, XYY syndrome and XXYY syndrome.