Coloboma of the eye is visible in the retina as "hole" in its structure, and causes low vision, possible sensitivity to light and variance in size of the eyeball.[11][12] The build-up of tissue in the liver, known as hepatic fibrosis, may cause symptoms such as jaundice, ascites, abnormal bleeding and enlarged spleen.[13] Kidney complications in the form of polycystic kidney or nephronophthisis is estimated to affect 77% of patients suffering from COACH syndrome, and is therefore a highly significant symptom of the disease.[4]