The efficacy of the clinical treatment for A. bovis lesions is not always successful,[1] but conventional treatment plans involving combinations of broad-spectrum antibiotics and concurrent administration of iodide solutions have demonstrated success in reducing the inflammation and spread of the lesion.[20] Initial treatment involves surgical debridement of purulent and soft-tissue lesions followed by daily cleaning and flushing of the infection site with saline and povidone-iodine solution, respectively, for about 1 week.[21] Treatment success has been noted individually for both potassium iodide oral solution,[22] and for intravenous sodium iodide,[23] as well as when used conjunctively.[24] However, frequent treatment with iodide may lead to toxicity, and monitoring for clinical signs of iodine toxicity should be included throughout the course of treatment.[25] Consequently, administration of iodide should be either reduced or discontinued if such signs of toxicity are observed.[25] Antibiotic combinations of intramuscular penicillin and streptomycin are commonly used for 5–7 days, and have been widely associated with treatment success.[21] Additional antibiotics such as oxytetracycline, florfenicol, and cloxacillin have also demonstrated sensitivity.[20][25]