Sanjrani was elected to the Senate of Pakistan as an independent candidate on general seat from Balochistan in 2018 Pakistani Senate election.[4][5] He took oath as Senator on 12 March 2018.[6] On the same day, he was elected as 8th Chairman of the Senate of Pakistan.[3][6] He received 57 votes out of total 103 votes cast and defeated Raja Zafar ul Haq, a candidate of the Pakistan Muslim League (N) who obtained 46 votes. Sanjrani was voted into chairman position by the Pakistan Peoples Party, Muttahida Qaumi Movement, Pakistan Tehreek-e-Insaf and independent Senators from Balochistan and the Federally Administered Tribal Areas. He became the first ever Chairman of the Senate who hailed from province of Balochistan[7] and became the youngest-ever Chairman of the Senate at the age of 39.[8] He was relatively lesser known figure in Pakistan's political spectrum prior to being elected as Chairman of the Senate.[7][9][10]