At first, the primary antagonist was originally going to be featured in the first Spider-Man film where he is played by Ed Harris which was planned in the early draft of the script, but instead appeared in this sequel where Chris Cooper, Christopher Walken, and Robert De Niro were at additionally considered for the role of Doctor Octopus;[15] Molina was cast as Octavius in February 2003 and underwent physical training for the role.[16] Raimi had been impressed by his performance in Frida and also felt he had the physicality.[17] Molina only briefly discussed the role and was not aware that he was a strong contender,[9] and was excited, being a big fan of Marvel Comics.[19] Although he was not familiar with Doc Ock, Molina found one element of the comics that he wanted to maintain, and that was the character's cruel, sardonic sense of humor.[20] Rosemary Harris as May Parker: Ben Parker's widow and Peter's aunt.[21] Donna Murphy as Rosalie Octavius: Otto's wife and assistant.[22]