Meyer returned to Singapore in 1873 and founded his own import-export business known as Meyer Brothers involved in the opium trade.[7] The firm grew to dominate all trade with India, linked by the two then flourishing Baghdadi Jewish communities of Calcutta and Singapore. Raphael Sassoon, born in Aleppo, and another Jewish pioneer was his partner in the firm and later also jointly a trustee of Maghain Avoth Synagogue on the island.[8]