She was the daughter of Kusumoto Taki, who was a courtesan from Nagasaki; and the German physician Philipp Franz von Siebold, who worked on Dejima, an island foreigners were restricted to during Japan's long period of seclusion from the world. Ine was also known as O-Ine and later in life took the name Itoku (伊篤). In Japanese she is often called Oranda O-Ine ("Dutch O-Ine") for her association with Dejima and its Dutch-language Western learning.