In this sense, the transdisciplinary and biomimetics research of Javier Collado [11] on Big History represents an ecology of knowledge between scientific knowledge and the ancestral wisdom of native peoples, such as Indigenous peoples in Ecuador. According to Collado,[12] the transdisciplinary methodology applied in the field of Big History seeks to understand the interconnections of the human race with the different levels of reality that co-exist in nature and in the cosmos, and this includes mystical and spiritual experiences, very present in the rituals of shamanism with ayahuasca and other sacred plants. In abstract, the teaching of Big History in universities of Brazil, Ecuador, Colombia, and Argentina implies a transdisciplinary vision that integrates and unifies diverse epistemes that are in, between, and beyond the scientific disciplines, that is, including ancestral wisdom, spirituality, art, emotions, mystical experiences and other dimensions forgotten in the history of science, specially by the positivist approach.