Naltrexone, an opioid receptor antagonist, is frequently prescribed to patients suffering from alcohol use disorder, with moderate effectiveness.[20] Studies have demonstrated that naltrexone reduces the stimulating and heightens the aversive sedative effects of alcohol in individuals at-risk for alcohol use disorder, contributing to decreases in self-reported subjective high and liking of alcohol.[21][22][23] Only one study has reported on the effects of naltrexone on SR in a sample of participants with alcohol dependence: naltrexone, in comparison to a placebo, attenuated subjective stimulation within 10 minutes of administration of a moderate dose of alcohol, but not thereafter.[24]