Anxiety has been estimated to have a prevalence in PD affected people around 30%-40% (however up to 60% has been found).[1][2] Anxiety can often be found during "off" periods (periods of time where medication is not working as well as it did before) with PD affected people suffering from panic attacks more frequently compared to the general population. Both anxiety and depression have been found to be associated with decreased quality of life.[10][51] Symptoms can range from mild and episodic to chronic with potential causes being abnormal gamma-aminobutyric acid levels as well as embarrassment or fear about their symptoms/disease.[10][51] Risk factors for anxiety in PD are disease onset under age 50, women, and "off" periods.[10]