The most common side effects reported in clinical trials include nausea, dizziness, headache, vomiting, sleepiness, and bed-wetting.[12][13] Some patients treated with sodium oxybate have also experienced moderate to significant weight loss. This may be due to the fact that sodium oxybate improves sleep architecture and increases the length of deep sleep stages, resulting in increased production of human growth hormone (HGH) and changes in energy metabolism.[14] The weight loss could also be due to decreased daytime appetite (experienced by many users) and the instructions to not eat for two hours before bedtime. Serious side effects, as listed on all prescriptions of sodium oxybate, can include hallucinations, agitation, severe mental confusion, abnormal thinking, disrupted sleep, and depression.