The Safavid dynasty made Shi'a Islam the official state religion in the early sixteenth century and aggressively proselytized on its behalf. It is also believed that by the mid-seventeenth century most people in Iran, Iraq and the territory of the contemporary neighboring Republic of Azerbaijan had become Shi'as,[7] an affiliation that has continued. Over the following centuries, with the state-fostered rise of a Persian-based Shi'ite clergy, a synthesis was formed between Persian culture and Shi'ite Islam that marked each indelibly with the tincture of the other.