One explanation for this phenomenon is that the experiences of elevated intoxication constitutes a feedback mechanism, which prompts drinking cessation. Low-level responders need to consume more alcohol than high responders to achieve a similar level of intoxication and experience the aversive effects of alcohol; consequently, these individuals must consume more alcohol to trigger the negative feedback loop.[1][2] Escalating alcohol consumption may ultimately contribute to the development of tolerance, which further dampens sensitivity to alcohol's unpleasant effects. Notably, there is no population-level demarcation separating low from high responders and so level of response is arbitrarily defined (generally in terciles) within a given sample.[3]