2,4-Dinitrophenol (DNP) is a very dangerous thermogenic drug used for fat loss; it will give a dose-dependant increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain. This stops the mitochondria from producing adenosine triphosphate, releasing energy as heat.