The novel explores how world history might have been different if the Black Death plague had killed 99% of Europe's population, instead of a third (because fewer cats/more rats). Divided into ten parts, the story spans hundreds of years, from the army of the Muslim conqueror Timur to the 21st century, with Europe being re-populated by Muslim pioneers, the indigenous peoples of the Americas forming a league to resist Chinese and Muslim invaders, and a 67-year-long world war being fought primarily between Muslim states and the Chinese and their allies. While the ten parts take place in different times and places, they are connected by a group of characters that are reincarnated into each time but are identified to the reader by the first letter of their name being consistent in each life.