In large doses, atropine sulfate helped control the involuntary movements associated with klazomania in one patient; attempts to treat with a combination of phenobarbital and trihexyphenidyl (also known as Artane) were also made. Phenobarbital acts as an anticonvulsant and is generally used to treat seizures, while Artane is used to treat involuntary movements in Parkinson's disease; however, this combination was found to have no beneficial effect in treating klazomania.[2] Klazomania does not respond to anti-epileptic medications.[3]