The story involves a powerful new substance called Iso-8 and Norman Osborn's attempts to supplant S.H.I.E.L.D. There are five missions to stop Osborn on his worldwide terror spree.[1] The original story is based on the Dark Reign storyline and was written by Frank Tieri and Alex Irvine.[10] Irvine also wrote other player versus environment events of the game, such as “Webbed Wonder,” where Spider-Man teams up with Howard the Duck to find out Aunt May's whereabouts.[11]