Many IGRs are labeled "reduced risk" by the Environmental Protection Agency, meaning that they target juvenile harmful insect populations while causing less detrimental effects to beneficial insects. Many beekeepers have reported IGR's negatively affecting brood and young bees. Unlike classic insecticides, IGRs do not affect an insect's nervous system and are thus more friendly to "worker insects" within closed environments.[2] IGRs are also more compatible with pest management systems that use biological controls.