Fetal pain, its existence and its implications are debated politically and academically. According to the conclusions of a review published in 2005, "Evidence regarding the capacity for fetal pain is limited but indicates that fetal perception of pain is unlikely before the third trimester."[33][34] However, developmental neurobiologists argue that the establishment of thalamocortical connections (at about 6-1/2 months) is an essential event with regard to fetal perception of pain.[35] Nevertheless, the perception of pain involves sensory, emotional and cognitive factors and it is "impossible to know" when pain is experienced, even if it is known when thalamocortical connections are established.[35] Some authors [36] argue that fetal pain is possible from the second half of pregnancy: “The available scientific evidence makes it possible, even probable, that fetal pain perception occurs well before late gestation” wrote KJS Anand in the journal of the IASP.[37]