As a result he entered the top 50 at World No. 48 in the singles rankings on 19 April 2021. At the French Open, Davidovich Fokina reached his first Grand Slam quarterfinals following wins over 15th-seeded Casper Ruud and Federico Delbonis.[4] This successful run improved his career-high ranking to World No. 35 in singles on 14 June 2021.