The Syrian town was refounded as a Hellenistic military settlement by Seleucus I Nicator in c. 303 BC, named Edessa after the ancient capital of Macedonia, perhaps due to its abundant water, just like its Macedonian eponym.[2][3][4][5] It was renamed Callirrhoe or Antiochia on the Callirhoe (Ancient Greek: Ἀντιόχεια ἡ ἐπὶ Καλλιρρόης; Latin: Antiochia ad Callirhoem) in the 2nd century BC (found on Edessan coins struck by Antiochus IV Epiphanes, r.