Androgenic side effects are of concern, as some women taking danazol may experience unwanted hair growth (hirsutism), acne, irreversible deepening of the voice,[9] or adverse blood lipid profiles.[15] In addition, breast atrophy and decreased breast size may occur.[9] The drug may also cause hot flashes, elevation of liver enzymes, and mood changes.[15] Some patients who use danazol experience weight gain and fluid retention. Due to its side effects, danazol is seldom prescribed continuously beyond six months.