The usage of the live attenuated strain of Mycobacterium Bovis, also known as Bacillus Calmette-Guérin (BCG), is a confirmed treatment for bladder cancer. BCG therapy is done by intravesical instillation (drug administration into the urinary bladder via a catheter) and has been used since 1970 on cancer patients.[5] Due to the necrotic and hypoxic regions of tumor cells (area of treatment resistance), drug delivery of chemotherapy can be impaired.