Latera and its castle are known by documents from around the beginning of the 12th century. It began its long-lasting link with the Farnese family in 1408, when Pope Gregory XII conceded vicardom of the city to Ranuccio Farnese, creating with the namesake city of Farnese a Duchy independent from that of the nearby Castro. The Farnese reigned over Latera until 1650.