Cytology is the name given to the branch of biology that deals with the formation, structure and functionality of the cells.[1] Liver cytology specializes in the study of liver cells. The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages).[2] The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules.[3] In the fetus, the liver works as a principal center for hematopoiesis, function that is later replaced by the bone marrow.