Clear fluid may come from the affected areas, which often thicken over time.[1] It typically starts in childhood with changing severity over the years.[1][2] In children under one year of age much of the body may be affected. As they get older the back of the knees and front of the elbows are the most common area for the rash. In adults the hands and feet are most affected.[2] Scratching worsens symptoms and affected people have an increased risk of skin infections.