Bone marrow: Pancytopenia with superadded infection usually implies a poor prognosis. Anemia can be due to a number of factors and does not necessarily imply bone marrow infiltration. Lymph node: Enlargement of the liver in 20%, spleen in 30% and lymph nodes in 50% of Histiocytosis cases.[24] Endocrine glands: Hypothalamic pituitary axis commonly involved.[25] Diabetes insipidus is most common.[26] Anterior pituitary hormone deficiency is usually permanent.[27] Lungs: some patients are asymptomatic, diagnosed incidentally because of lung nodules on radiographs; others suffer from chronic cough and shortness of breath.[28] Less frequently gastrointestinal tract, central nervous system, and oral cavity.[29]