Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects.[6][7][8][9] However, in clinical trials, imipraminoxide was found to have a faster onset of action, slightly higher efficacy, and fewer and less marked side effects, including diminished orthostatic hypotension and anticholinergic effects like dry mouth, sweating, dizziness, and fatigue.[6][7][8][9][10][11]