Wnt also has inhibitors like noggin to allow for the formation of dorsal tissue. In order to aid in proper development fish have an organizer center called the Nieuwkoop center.[9] Anterior and posterior axis formation seems to be the result of interplay of FGFs, Wnt, and retinoic acid. FGFs, retinoic acid, and Wnts are required to turn on posterior genes.[8]