In 1999 PSORT was the first published program to predict subcellular localization.[3] Subsequent tools and websites have been released using techniques such as artificial neural networks, support vector machine and protein motifs. Predictors can be specialized for proteins in different organisms. Some are specialized for eukaryotic proteins,[4] some for human proteins,[5] and some for plant proteins.[6] Methods for the prediction of bacterial localization predictors, and their accuracy, have been reviewed.[7]