Ashraf Qazi was born as the only son to an ethnic Hazara father, Qazi Mohammad Musa,[3][4] and an Irish mother, Jennifer Musa.[5] His father belonged to the prominent Qazi family of Balochistan, whose notable members included Ashraf's paternal uncle, Qazi Muhammad Essa, a leading figure of the Pakistan Movement;[3] and Essa's son Qazi Faez Isa, a Supreme Court justice who formerly served as the Chief Justice of Balochistan High Court.[4] Ashraf's paternal grandfather served as the prime minister of the princely Kalat State.[3]