While scars are associated with the desmoplastic response of various cancers, not all scars are associated with malignant neoplasms.[3] Mature scars are usually thick, collagenous bundles arranged horizontally with paucicellularity, vertical blood vessels, and no appendages.[3] This is distinguished from desmoplasia in the organization of the tissue, the appendages, and orientation of blood vessels. Immature scars are more difficult to distinguish due to their neoplastic origins.[3] These scars are hypercellular with fibroblasts, myofibroblasts, and some immune cells present.[3] The immature scars can be distinguished from desmoplasia by immunohistochemical staining of biopsied tumors that will reveal the type and organization of cells present as well as whether recent trauma has occurred to the tissue.[17]