Mor Gregorios Joseph was born as the youngest of four children to Srambikkal Pallithitta Geevarghese and Saramma in Perumpilly, Mulanthuruthy. He is the grandchild of the cousin of Geevarghese Gregorios of Parumala. Joseph had his primary education at Perumpally Primary School and high school education from Mulanthuruthy High School.