As reported in an annual update of progress against UK targets, factors such as levels of infectious disease domestically or internationally, weather and vaccine availability can all affect antibiotic use.[141] For example, the Scottish salmon farming sector worked with Government and researchers to introduce a vaccine for the disease Furunculosis (Aeromonas salmonicida) in 1994, which significantly reduced the need for antibiotic treatments,[142] but the trout sector is still without an effective vaccine for this disease.