The episode opens with Stewie revealing his ability to travel across parallel universes to Brian. The first universe that they decide to visit, after having questioned the origin of Stewie's pedigree pig, is said to exist in a world where Christianity is absent.[21] In this universe, everything is seemingly years in advance of the 21st century; Quagmire is able to take a single pill and be instantly cured of the AIDS virus, and flying cars and buildings surround them.[22] As the two travel through the universe, they come upon Stewie's older sister Meg, who has become significantly more attractive. While they watch her walk down the street, the 1984 single "Drop Dead Legs" by Van Halen plays.[23] Playing on the nonexistence of Christianity, Brian and Stewie visit the Sistine Chapel and discover that a large collection of photos of American actress Jodie Foster has been substituted for The Creation of Adam painting by Michelangelo, who was fired and replaced by John Hinckley.[21]