They can be detected using Janus green B or enzimo-histochemistry. Hepatocytes possess multiple Golgi complexes, and have large numbers of peroxisomes, which can be detected with immunohistochemistry. Smooth endoplasmic reticulum can be extensive and may contain enzymes involved in degradation and conjugation of toxins and drugs, and other enzymes involved in the synthesis of cholesterol and lipoproteins.[2]