The Alexandria School of Medicine is one of the oldest empirical educational institutions in the history of medicine initiated during the Hellenistic period in the city of Alexandria 311 BC. At one historical juncture, in Egypt, they united all the different medical doctrines that originated in the East and in Alexandria (increasingly resembling a cosmopolitan city), and merged into one universal "critical mass of knowledge" the Alexandrian empirical school.[1] As the Alexandria School grows more developed Medical Schools in Knossos and in Knidos over time lost their meaning and significance.