Main mucopolysaccharidoses Type[1] Common name Other names OMIM Gene Locus Deficient enzyme Accumulated products Symptoms Incidence MPS IH Hurler syndrome 607014 IDUA 4p16.3 α-L-iduronidase Heparan sulfate Dermatan sulfate Intellectual disability, micrognathia, coarse facial features, macroglossia, retinal degeneration, corneal clouding, cardiomyopathy, hepatosplenomegaly 1:100,000[2] MPS IH/S Hurler–Scheie syndrome 607015 MPS IS Scheie syndrome Formerly: Mucopolysaccharidosis type V 607016 MPS II Hunter syndrome 309900 IDS Xq28 Iduronate sulfatase Heparan sulfate Dermatan sulfate Intellectual disability (similar, but milder, symptoms to MPS I).