About a quarter of those with Brugada syndrome have a family member who also has the condition.[1] Some cases may be due to a new genetic mutation or certain medications.[2] The most commonly involved gene is SCN5A which encodes the cardiac sodium channel.[3] Diagnosis is typically by electrocardiogram (ECG), however, the abnormalities may not be consistently present.[2] Medications such as ajmaline may be used to reveal the ECG changes.[2] Similar ECG patterns may be seen in certain electrolyte disturbances or when the blood supply to the heart has been reduced.[4]