Bagot’s uses a multidisciplinary approach to research stress and depression. In her Behavioral Neurogenomics Laboratory and as a primary investigator at the Ludmer Centre for Neuroinformatics and Mental Health, she combines molecular, cellular, and behavioral technology, including in vitro electrophysiology, in vivo optogenetics, in vivo calcium imaging, and next-generation sequencing in rodent behavioral models, to investigate the genomics and circuit changes that may drive depressive behaviors.[3]