Bottom: Ottoman depiction of the siege of Nice by Matrakçı Nasuh. Date 6–22 August 1543[1] Location Nice, Savoy Result Ottomans and French sack Nice. Belligerents Holy Roman Empire Savoy Genoa Ottoman Empire France Commanders and leaders Charles V Charles III Andrea Doria Hayreddin Barbarossa Salah Rais François de Bourbon Strength 100 galleys 30,000 soldiers 50 galleys Casualties and losses 4 galleys 5,000 captives.