Plasma Component Reasons for Use factor VIII hemophilia A factor IX hemophilia B Factor X congenital deficiency factor XIII congenital deficiency PCC complex anticoagulant overdose factor II and factor X if Factor X not available deficiencies liver disease immunoglobulin passive prophylaxis immune deficiency disorders some types of immune thrombocytopenic purpura Guillain–Barré syndrome Polyneuropathies antithrombin III congenital deficiency disseminated intravascular coagulation fibrinogen congenital deficiency massive haemorrhage C1 inhibitor hereditary angioedema albumin hypoalbuminemia Ascites Restoring of blood volume in trauma, burns and surgery patients alpha-I-antitrypsin hereditary deficiencies emphysema and COPD cirrhosis