Prolonged stress can disturb the immune, digestive, cardiovascular, sleep, and reproductive systems.[10] Other symptoms people may experience include anxiety,[10] depression,[11] sadness,[10] anger,[10] irritability,[10] social isolation, headache,[10] skin problems, menstrual problems,[12] abdominal pain, back pain and difficulty concentrating.[13] Other symptoms include panic attacks or a panic disorder.[11] Chronic stress can increase an individual's risk for psychiatric disorders and some physical disorders such as cardiovascular diseases, high blood pressure, and diabetes.[10][11]