Massa was the author of several works beginning with a book on the French Disease which is commonly equated to modern day syphilis in 1524, Liber morbo gallico which went through several editions. This was followed by a book on anatomy, Anatomiae Libri Introductorius, a book on fevers, the Liber de febre pestilentiali, a work in Italian, the La loica, divisa in sette libri, and a collection of his letters, Epistolae medicinales Printed collections of letters from physicians was a popular genre in the sixteenth century. The letter tended to be written diagnosis and treatment advice, but they touched on a variety of topics.