Absence of the septum pellucidum occurs in septo-optic dysplasia, a rare developmental disorder usually characterized by abnormal development of the optic disk and pituitary deficiencies.[6] Symptoms of septo-optic dysplasia are highly variable and may include vision difficulties, low muscle tone, hormonal problems, seizures, intellectual problems, and jaundice at birth.[6] Management is directed at the symptoms a person is affected with.[6]