The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass.[10] Moderate toxicity occurs at doses up to 300 mg/kg, severe toxicity occurs between 300 and 500 mg/kg, and a potentially lethal dose is greater than 500 mg/kg.[11] Chronic toxicity may occur following doses of 100 mg/kg per day for two or more days.[11]