CD40 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI Identifiers Aliases CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule External IDs MGI: 88336 HomoloGene: 954 GeneCards: CD40 Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,118,272 bp[1] End 46,129,863 bp[1] Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.38 cM Start 165,055,627 bp[2] End 165,072,948 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • antigen binding • signal transducer activity • protein binding • tumor necrosis factor-activated receptor activity • enzyme binding • ubiquitin protein ligase binding • receptor activity • protein domain specific binding Cellular component • cytoplasm • integral component of membrane • intracellular membrane-bounded organelle • membrane • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • CD40 receptor complex • extracellular exosome • external side of plasma membrane • extracellular space • neuronal cell body • varicosity Biological process • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • protein kinase B signaling • protein complex assembly • regulation of immunoglobulin secretion • positive regulation of protein kinase C signaling • immune system process • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • immune response • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • positive regulation of transcription from RNA polymerase II promoter • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 958 21939 Ensembl ENSG00000101017 ENSMUSG00000017652 UniProt P25942 P27512 RefSeq (mRNA) NM_001250 NM_001302753 NM_152854 NM_001322421 NM_001322422 NM_001362758 NM_011611 NM_170702 NM_170703 NM_170704 RefSeq (protein) NP_001241 NP_001289682 NP_001309350 NP_001309351 NP_690593 NP_001349687 NP_035741 NP_733803 NP_733804 NP_733805 Location (UCSC) Chr 20: 46.12 – 46.13 Mb Chr 2: 165.06 – 165.07 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse