Mingueza made his first team debut for Barcelona on 24 November 2020, as a replacement for the injured Gerard Piqué, starting the 4–0 2020–21 UEFA Champions League group stage victory against Dynamo Kyiv at the NSC Olimpiyskiy in Kyiv.[4] Five days later, he made his La Liga debut in a 4–0 win against Osasuna at Camp Nou.