Developed by Uri Sivan, Erez Braun and Yoav Eichen from the Technion.[26] World's smallest DNA computing machine system – "the smallest biological computing device" ever constructed, according to Guinness Book of Records, which is composed of enzymes and DNA molecules capable of performing simple mathematical calculations and which uses its input DNA molecule as its sole source of energy. Developed in 2003 in the Weizmann Institute of Science by professor Ehud Shapiro and his team.[27][28]