A Court Jew,[2] he was appointed the Lord of Tiberias,[3] with the expressed aim of resettling Jews in Ottoman Syria and encouraging industry there; the attempt failed, and, later, he was appointed to the Duke of Naxos.[4] Nasi also brought about war with the Republic of Venice, at the end of which Venice lost the island of Cyprus to the Ottomans. After the death of Selim, he lost influence in the Ottoman Court, but was allowed to keep his titles and pension for the remainder of his life.