It is estimated that Angelović was born in the early 1420s.[2] Most historians accept that Angelović was born in Novo Brdo in the Serbian Despotate, and that his father Mihailos was the son of either Alexios Angelos Philanthropenos or his son/nephew/brother Manuel, rulers of Thessaly.[3] T. Stavrides views it more probable that Manuel was his grandfather.[2] The only information on his father is that he lived in Serbia in the 1420s.[2] His mother's ancestry is the matter of debate. Chalkokondyles (1430–1470) called her Serbian, Kritoboulos (1410–1470), Greek, while there are various theories on her noble ancestry.[4] Angelović had a brother, Mihailo Anđelović, later a prominent Serbian statesman.[5]