Poser diagnosis of CDMS was initially reported to have a sensitivity of 87% respect postmortem autopsy examination.[5] Poser criteria were published in 1983 and their sensitivity increased with time. For example, in 1988 a 94% specificity vs. postmortem analysis was reported [6]Anyway, in initial cases, the sensitivity was low respect pathologically defined MS because around 25% of MS cases are silent MS cases.[7]