Juffali was born in Jeddah on 30 April 1955,[5] the son of Ahmed Abdullah Juffali (1924–1994),[6] the founder of E. A. Juffali and Brothers, one of Saudi Arabia's largest companies.[7] This wealthy and secretive family was from Unayzah, Al-Qassim.[8] The Al-Juffali are members of Bani Khalid dynasty, rulers of Eastern Arabia during the early 1600s to the late 1800s after military defeats against the Saudis.[9] The Family are most notable for being direct descendants of Khālid ibn al-Walīd.