Much research has focused on the nonpolio enteroviruses 68 (EV-D68) and 71 (EV-A71), a common cause of hand, foot, and mouth disease in infants and young children, members of the enterovirus D and enterovirus A species, respectively, as suspected causes.[1] Some evidence supports a causal role of EV-D68.[12] Coxsackievirus A16 may also play a role in some cases.[13]