At Clark University, Margaret met Leonard Blaine Nice (referred to by his middle name) and they married in 1908. Blaine served as an instructor in physiology for two years at Harvard Medical School following which the family moved to Norman, Oklahoma where Blaine had accepted a faculty position in physiology and pharmacology at the university.[4] They had five children, Constance, born 1911, Marjorie, 1912, Barbara, 1916, Eleanor, 1918, and Janet, born 1922.