The structures of several interesting ion channels are now in the public domain. For example, the crystal structure of a glutamate-gated chloride channel in complex with ivermectin was reported in 2011 and represents a starting point for the design of novel insecticides. This structure led to a homology model for a related γ-aminobutyric acid (GABA)–gated chloride channel and a binding mode for the meta-diamides, another insecticide class.[1]