Diseases, both real and fictional, play a significant role in both literary and science fiction, some like Huntington's disease and tuberculosis appearing in many books and films. Pandemic plagues threatening all human life, such as The Andromeda Strain, are among the many fictional diseases described in literature and film. Science fiction takes an interest, too, in imagined advances in medicine.[7][8] The Economist suggests that the abundance of apocalyptic fiction describing the "near annihilation or total extinction of the human race" by threats including deadly viruses rises when general "fear and unease", as measured by the Doomsday Clock, increase.[9]