FIV is known in other feline species, and in fact is endemic in some large wild cats, such as African lions. Three main clades of FIV are recognized as of 2006, FIV-Ple (lion), FIV-Fca (domestic cat), and FIV-Pco (puma).[6] The host boundaries are usually well-kept due to the limited types of APOBEC3 enzymes viral Vif can neutralize.[7]