From 1933, the company, with expanded production facilities, concentrated its business activities exclusively around the Berlin area. In 1938, a Temmler chemist in Berlin synthesised Pervitin (methamphetamine-hydrochloride), the pharmaceutical drug was then manufactured and dispensed over-the-counter to the public as a central nervous system and circulatory system analeptic, psychiatric performance enhancing stimulant and to induce or extend wakefulness to treat narcolepsy.[2][3] Pervitin was made available and packaged in thirty tablet oral dosage form, and in six 1ccm glass ampulla form as an intramuscular or intravenous injectable. The company became especially known for the introduction of its methamphetamine-hydrochloride preparation brand Pervitin, which the company produced from 1938 up until 1988.[2]