During the journey the astronauts would be subject to radiation, which would require a means to protect them. Cosmic radiation and solar wind cause DNA damage, which increases the risk of cancer significantly. The effect of long-term travel in interplanetary space is unknown, but scientists estimate an added risk of between 1% and 19% (one estimate is 3.4%) for men to die of cancer because of the radiation during the journey to Mars and back to Earth.