Patients with Norrie disease may develop cataracts, leukocoria (a condition where the pupils appear white when light is shone on them), along with other developmental issues in the eye, such as shrinking of the globe and the wasting away of the iris.[1] Around 30 to 50% of them will also have developmental delay/mental retardation, psychotic-like features, incoordination of movements or behavioral abnormalities.[1] Most patients are born with normal hearing; however, the onset of hearing loss is very common in early adolescence.[2] About 15% of patients are estimated to develop all the features of the disease.[3]