CD40LG Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ALY, 1I9R, 3LKJ, 3QD6 Identifiers Aliases CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand External IDs OMIM: 300386 MGI: 88337 HomoloGene: 56 GeneCards: CD40LG Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,648,193 bp[1] End 136,660,390 bp[1] Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A6|X 31.21 cM Start 57,212,143 bp[2] End 57,224,042 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • cytokine activity • CD40 receptor binding • tumor necrosis factor receptor binding • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • external side of plasma membrane • intracellular • cell surface • extracellular space Biological process • leukocyte cell-cell adhesion • positive regulation of interleukin-12 production • regulation of immunoglobulin secretion • immunoglobulin secretion • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • platelet activation • positive regulation of endothelial cell apoptotic process • B cell proliferation • isotype switching • immune response • regulation of immune response • B cell differentiation • inflammatory response • T cell costimulation • positive regulation of NF-kappaB transcription factor activity • activation of JUN kinase activity • positive regulation of interleukin-4 production • positive regulation of interleukin-10 production • positive regulation of T cell proliferation • regulation of receptor activity Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 959 21947 Ensembl ENSG00000102245 ENSMUSG00000031132 UniProt P29965 P27548 RefSeq (mRNA) NM_000074 NM_011616 RefSeq (protein) NP_000065 NP_035746 Location (UCSC) Chr X: 136.65 – 136.66 Mb Chr X: 57.21 – 57.22 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse