The entorhinal cortex is the first area of the brain to be affected in Alzheimer's disease; a recent functional magnetic resonance imaging study has localised the area to the lateral entorhinal cortex.[1] Lopez et al.[2] have shown, in a multimodal study, that there are differences in the volume of the left entorhinal cortex between progressing (to Alzheimer's disease) and stable mild cognitive impairment patients. These authors also found that the volume of the left entorhinal cortex inversely correlates with the level of alpha band phase synchronization between the right anterior cingulate and temporo-occipital regions.