The signal going across the synapses could be modeled either as a deterministic or a stochastic process based on the application (See Section 3.7). Another anatomical complication is when a population of neurons, such as a column of neurons in visionary system, needs to be handled. This is done by considering the collective behavior of the group (Kotter, R., Nielson, P., Dyhrfjeld-Johnson, J., Sommer, F. T., & Northoff, G. (2002)[25]).