In 2016, the results of a Phase II Trial, in which Voskuhl participated, were released, detailing an experiment in which women with RRMS were treated daily with 8 mg estriol or placebo, combined with 20 mg injectable glatiramer acetate - an immunomodulator currently used to treat MS. It was found that women with the estriol treatment had significantly less relapses than the placebo group (0.25 relapses/year and 0.37 relapses/year, respectively), with similar amounts of serious adverse health events. The success of this trial convinced the authors to report that a Phase III Trial was warranted.[11]