Prostate cancer kills around 35,000 men yearly, and about 220,000 men are diagnosed with prostate cancer per year, in North America alone.[100] Prostate cancer is the second leading cause of cancer-caused fatalities in men, and within a man's lifetime, one in six men will have the disease.[100] Alterations in histone acetylation and DNA methylation occur in various genes influencing prostate cancer.[101] More than 90% of prostate cancers show gene silencing by CpG island hypermethylation of the GSTP1 gene promoter, which protects prostate cells from genomic damage that is caused by different oxidants or carcinogens.[102] Real-time methylation-specific polymerase chain reaction (PCR) suggests that many other genes are also hypermethylated.[102] Gene expression in the prostate may be modulated by nutrition and lifestyle changes.[103]