Kufor–Rakeb syndrome is associated with mutations in the ATP13A2 gene.[8] The inheritance pattern for KRS is autosomal recessive.[9] If a male and female carrier, who has one recessive allele for the ATP13A2 gene mutation and one dominant allele for the ATP13A2 gene, have a child, there is a 25% chance the child has KRS, a 50% chance the child is a carrier for KRS, and a 25% chance the child does not have KRS.[3]