This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states. ↑ Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (2012). "Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms".