Pyloroplasty can be performed on a narrowed or thickened pylorus, but also on a normal pylorus.[3] Pyloroplasty is used to treat those who have complications causing a blockage of the pylorus, commonly peptic ulcers.[2] It also can be performed on patients at high risk for gastric or peptic ulcer disease (PUD).[4] Pyloroplasty is almost never performed by itself; it is most commonly paired with another procedure like a vagotomy.[3]