The greatest use of the term since its coinage has been in relation to the annual Bioneers conference founded by Ausubel and his wife Nina Simons and held annually in San Rafael, California, and its participants. However, in recent years the term or derivations has seen increasing use independent of the Bioneers organization, suggesting an increasing acceptance of the term in popular usage. For example, a 2005 article on the use and manufacture of biodiesel fuels in northern California was titled "Bioneering Biodiesel."[2] An April 2007 symposium and art exhibition at University of California, Irvine focused on food production, consumption, and distribution was called "Bioneering: Hybrid Investigations of Food."[3]