The 1510 flu is suspected of originating in East Asia,[1] possibly China.[2] Gregor Horst writes in Operum medicorum tombus primus (1661) that the disease came from Asia and spread along trade routes[1] before attacking the Middle East and North Africa. German medical writer Justus Hecker suggested the 1510 influenza most likely came from Asia because of the historical nature of other influenzas to originate there in more recent pandemics.[3]