However, their subsequent offspring will lack tetracycline in the wild and never mature.[11] Field trials were conducted in the Cayman Islands, Malaysia and Brazil to control the mosquitoes that cause dengue fever. In April 2014, Brazil’s National Technical Commission for Biosecurity approved the commercial release of the modified mosquito.[12][13] The FDA is the lead agency for regulating genetically-engineered mosquitoes in the United States.[14] The review by its Center for Veterinary Medicine of a genetically engineered protein to increase the milk output of dairy cows took nine years. In the 1990s, it began a nearly 20 year review of a genetically engineered Atlantic salmon which was approved in 2015.[15][16][17]