Infectious disease, e.g., influenza, primary HIV infection, malaria, Ebola, infectious mononucleosis, gastroenteritis, Lyme disease, Dengue Various skin inflammations, e.g., boils, abscess Immunological diseases, e.g., lupus erythematosus, sarcoidosis, inflammatory bowel diseases, Kawasaki disease, Still disease, Horton disease, granulomatosis with polyangiitis, autoimmune hepatitis, relapsing polychondritis[39] Tissue destruction, which can occur in hemolysis, surgery, infarction, crush syndrome, rhabdomyolysis, cerebral bleeding, etc. Reaction to incompatible blood products Cancers, most commonly kidney cancer and leukemia and lymphomas Metabolic disorders: gout, porphyria Inherited metabolic disorder: Fabry disease[40]