The pterygomandibular space is the area where local anesthetic solution is deposited during an inferior alveolar nerve block, a common procedure used to anesthetize the distribution of the inferior alveolar nerve. Rarely, pathogenic micro-organisms from the mouth may be seeded into the pterygomandibular space during this injection and cause a needle tract infection of the space.[1] It is also occasionally reported that the needle breaks off and is retained in the pterygomandibular space during this injection.[3] Minor oral surgery is then required to remove the fractured needle.[3] Due to its high vascularity, injections into the pterygomandibular space carry a high risk of intravascular injection (injecting into a blood vessel).[4] Another possible complication of an inferior alveolar nerve block occurs when the needle is placed too deep, passing through the pterygomandibular space and into the parotid gland behind. Branches of the facial nerve (which gives the motor supply to the muscles of facial expression) run through the substance of the parotid gland and so this is manifest as a transient facial palsy.