STAT3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AX3 Identifiers Aliases STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1 External IDs OMIM: 102582 MGI: 103038 HomoloGene: 7960 GeneCards: STAT3 Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,313,324 bp[1] End 42,388,568 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.82 cM Start 100,885,098 bp[2] End 100,939,540 bp[2] RNA expression pattern More reference expression data Gene ontology Molecular function • protein dimerization activity • CCR5 chemokine receptor binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein phosphatase binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • glucocorticoid receptor binding • protein binding • protein kinase binding • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • signal transducer activity • RNA polymerase II repressing transcription factor binding • identical protein binding • chromatin DNA binding • protein homodimerization activity Cellular component • cytoplasm • mitochondrion • nucleus • nuclear chromatin • plasma membrane • nucleoplasm • RNA polymerase II transcription factor complex • mitochondrial inner membrane • cytosol Biological process • movement of cell or subcellular component • negative regulation of glycolytic process • protein import into nucleus • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to organic substance • positive regulation of gene silencing by miRNA • cellular response to cytokine stimulus • radial glial cell differentiation • stem cell population maintenance • cellular response to hormone stimulus • regulation of mitochondrial membrane permeability • growth hormone receptor signaling pathway • miRNA mediated inhibition of translation • eye photoreceptor cell differentiation • positive regulation of metalloendopeptidase activity • temperature homeostasis • cell proliferation • response to leptin • response to ethanol • positive regulation of Notch signaling pathway • negative regulation of cell proliferation • response to cytokine • regulation of transcription, DNA-templated • glucose homeostasis • cytokine-mediated signaling pathway • negative regulation of cell death • transcription, DNA-templated • positive regulation of growth factor dependent skeletal muscle satellite cell proliferation • positive regulation of transcription, DNA-templated • negative regulation of hydrogen peroxide biosynthetic process • energy homeostasis • viral process • negative regulation of neuron death • sexual reproduction • phosphorylation • leptin-mediated signaling pathway • cellular response to organic cyclic compound • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of feeding behavior • nervous system development • positive regulation of ATP biosynthetic process • interleukin-6-mediated signaling pathway • intracellular receptor signaling pathway • acute-phase response • negative regulation of neuron migration • JAK-STAT cascade • response to estradiol • response to organic cyclic compound • eating behavior • somatic stem cell population maintenance • regulation of multicellular organism growth • aging • response to peptide hormone • cellular response to leptin stimulus • regulation of cell cycle • astrocyte differentiation • response to drug • signal transduction • positive regulation of transcription from RNA polymerase II promoter • JAK-STAT cascade involved in growth hormone signaling pathway • positive regulation of gene expression • negative regulation of stem cell differentiation • positive regulation of cell proliferation • mRNA transcription from RNA polymerase II promoter • inflammatory response • positive regulation of erythrocyte differentiation • T-helper 17 cell lineage commitment • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • interleukin-12-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 6774 20848 Ensembl ENSG00000168610 ENSMUSG00000004040 UniProt P40763 P42227 RefSeq (mRNA) NM_003150 NM_139276 NM_213662 NM_011486 NM_213659 NM_213660 RefSeq (protein) NP_003141 NP_644805 NP_998827 NP_035616 NP_998824 NP_998825 Location (UCSC) Chr 17: 42.31 – 42.39 Mb Chr 17: 100.89 – 100.94 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse