During her tenure as first lady, Moïse served as president of the Fondasyon Klere Ayiti, a community development organization focused on civic education and women's issues.[4] In October 2017, she became president of coordination for Global Fund in Haiti – CCM, which aims to alleviate HIV/AIDS, malaria, and other public health diseases in Haiti.[4] Moïse also advocated new investments in the Haitian arts and crafts industry in an effort to boost local artisans.[4]