As a result, transfusion of HbF in younger populations can prevent and slow the progression of sickle cell retinopathy.[1] Hydroxyurea administration - Hydroxyurea is a drug that can be used as an alternative method of increasing fetal haemoglobin levels in the blood of a patient with sickle cell disease.[2] Hydroxyurea also provides the benefit of reducing inflammation.[3] Haematopoetic stem cell transplantation - This process is more commonly known as a bone marrow transplant.