Round Matchups Round of 16 (Group winners host second leg) West Region Runner-up Group A vs. Winner Group B Runner-up Group B vs. Winner Group A Runner-up Group C vs. Winner Group D Runner-up Group D vs. Winner Group C East Region Runner-up Group E vs. Winner Group F Runner-up Group F vs. Winner Group E Runner-up Group G vs. Winner Group H Runner-up Group H vs. Winner Group G Quarter-finals (Matchups and order of legs decided by draw, involving four round of 16 winners each in West Region and East Region) West Region QF1 QF2 East Region QF3 QF4 Semi-finals (Winners QF1 and QF3 host first leg, Winners QF2 and QF4 host second leg) West Region SF1: Winner QF1 vs. Winner QF2 East Region SF2: Winner QF3 vs. Winner QF4 Final (Winner SF1 host first leg, Winner SF2 host second leg, as reversed from previous season's final) Winner SF1 vs. Winner SF2