Siebold was banished from Japan in 1829 but managed to provide for Ine and her mother and arranged for his students and associates to care for them. Ine's reputation grew after she became a doctor of Western medicine, and she won the patronage of the feudal lord Date Munenari. She studied in various parts of Japan under numerous teachers, one of whom impregnated her—likely having raped her—resulting in her only daughter; she never married.