Some topical glucocorticoids can cause hypothalamic-pituitary axis (HPA) suppression.[15] Reasons that lead to suppression of the HPA include the use of high-potency glucocorticoids, long-term use, application to highly permeable areas, treatment of large areas, occlusion, changed skin barrier and young age.[15] Regular use of even mild glucocorticoids in young kids can lead to HPA suppression.[16]