The production of organic solvents like acetone, butanol, and isopropanol through fermentation was one of the very first things to be produced by using bacteria, since achieving the necessary chirality of the products is easily achieved by using living systems.[8] Solvent fermentation uses a series of Clostridia bacterial species. Solvent fermentation at first was not as productive as it is used today. The amount of bacteria required to yield a product was high, and the actual yield of product was low.