This spreading may lead to larger tumors that would result in the inability to swallow.[4] Aesophageal webs – thin membranes located in the esophagus. Abnormalities can cause constrictions within the esophagus. Globus pharyngis – commonly referred to as lumps in ones throat [5] Myasthenia gravis – the thymus gland is thought to be necessary for the deletion of auto-reactive T cells, and seems to have an important role in the pathogenesis of myasthenia gravis.