Tsitsipas played in his first ATP main draw at the 2017 Rotterdam Open, where he lost his debut match to the eventual champion Jo-Wilfried Tsonga.[29] He also made his Grand Slam debut later that year as a qualifier at the French Open, but lost to Ivo Karlović in his first match.[30] After losing in qualifying at the US Open, Tsitsipas won his first Challenger title in Genova.[31] Overall, he qualified for a tour-best eight events during the season, including Wimbledon and the Shanghai Masters.[30] However, he did not win a tour-level match until the very end of the season when he defeated fellow Next Gen player Karen Khachanov in Shanghai.[32] At the European Open in Belgium the following week, Tsitsipas reached his first ATP semifinal as a qualifier.