While the most significant, but highly unlikely, health consequences to atmospheric radiation exposure include death from cancer due to long-term exposure, many lifestyle-degrading and career-impacting cancer forms can also occur.[21][22] A cancer diagnosis can have significant career impact for a commercial pilot. A cancer diagnosis can ground a pilot temporarily or permanently. International guidelines from the International Commission on Radiological Protection (ICRP) have been developed to mitigate this statistical risk.[23][24][25] The ICRP recommends effective dose limits of a 5-year average of 20 mSv per year with no more than 50 mSv in a single year for non-pregnant, occupationally exposed persons, and 1 mSv per year for the general public.