Kapiʻolani was born December 31, 1834, in Hilo on Hawaiʻi Island to High Chief Kūhiō Kalanianaʻole of Hilo and High Chiefess Kinoiki Kekaulike of Kauaʻi, the daughter of King Kaumualiʻi, the last king of an independent Kauaʻi before its cession to Kamehameha the Great.[5] Her two younger sisters were Kapoʻoloku Poʻomaikelani (1839–1895), who married Hiram Kahanawai, and Kinoiki Kekaulike (1843–1884), who married David Kahalepouli Piʻikoi.[6]