The Sisters of Mercy was founded by Catherine McAuley in Ireland in 1831, and her nuns went on to establish hospitals and schools across the world.[208] The Little Sisters of the Poor was founded in the mid-19th century by Saint Jeanne Jugan near Rennes, France, to care for the many impoverished elderly who lined the streets of French towns and cities.[209][210] In Britain's Australian colonies, Australia's first canonized Saint, Mary MacKillop, co-founded the Sisters of St. Joseph of the Sacred Heart as an educative religious institute for the poor in 1866, going on to establish schools, orphanages and refuges for the needy.[211] In 1872, the Salesian Sisters of Don Bosco (also called Daughters of Mary Help of Christians) was founded by Maria Domenica Mazzarello. The teaching order was to become the modern world's largest institute for women, with around 14,000 members in 2012.[5] Saint Marianne Cope opened and operated some of the first general hospitals in the United States, instituting cleanliness standards which influenced the development of America's modern hospital system.[212] Also in the United States, Saint Katharine Drexel founded Xavier University of Louisiana to assist African and Native Americans.[213]