Markos Khouzam was born in Akhmim, Sohag Governorate, Egypt and studied in Cairo in 1898. He was sent on a religious mission to Beirut, Lebanon in 1905 and became a priest on 30 April 1911 and was appointed in August 1926 as a pastor for Abou Korkas, and ordained as bishop on 30 November 1926 and archbishop of Tayibe, Dakahlia Governorate in Egypt.