Antibiotics: In early stages, penicillin or metronidazole are used in combination with topical antiseptic.[5] Improved nutrition and vitamins.[5] Non-adherent dressings and elevation of limbs.[5] Large infected ulcers may require debridement under anesthesia. Skin grafting may be helpful in advanced cases to ensure the lesion does not progress to chronic stage.[5] In extreme cases, amputation is necessary.