Messina made an appearance on the Emmy award-winning The Marvelous Mrs. Maisel alongside Alex Borstein as younger son in an Italian immigrant family[1][3] Between 2018 and 2021, Messina played Cal Stone on NBC's science fiction drama Manifest as a young boy struggling with terminal leukaemia and a passenger on the mysterious returning airplane Flight 828.[4][3][4] Messina has made appearances in commercials for Eliquis and MVP Health.[1] Messina is a member of SAG-AFTRA, which has strict rules about children working on set; Messina has private tutoring on site to keep up with schoolwork.[4]