Danazol is known to bind to two steroid hormone carrier proteins: sex hormone-binding globulin (SHBG), which binds androgens and estrogens; and transcortin (corticosteroid-binding globulin), which binds progesterone and cortisol.[9][18] Binding of danazol to SHBG is considered to be more important clinically.[18] By occupying SHBG and transcortin, danazol increases the ratio of free to plasma protein-bound testosterone, estradiol, progesterone, and cortisol.[9][18] The following table shows the difference in testosterone levels in untreated premenopausal women and women treated with danazol:[18]