Later, skin on the centre of the carbuncle softens and peripheral satellite vesicles appear, which rupture discharging pus and give rise to cribriform appearance.[1][6] As the impending infection develops, itching may occur. There may be localized erythema, skin irritation, and the area may be painful when touched. Sometimes more severe symptoms may occur, such as fatigue, fever, chills, and general malaise as the body fights the infection.[6]