When used in combination with an anticoagulant or antiplatelet drug, saw palmetto extract can increase the risk of bleeding by enhancing the anticoagulation or antiplatelet effects. Some examples of anticoagulant and antiplatelet drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs (NSAIDs), and warfarin. Therefore, the combination of saw palmetto extract with anticoagulant or antiplatelet drugs should be used with caution.[1]