Throughout the years advances in research have shown that neural formation relies on interactions between extrinsic signaling factors and intrinsic transcription factors. Extrinsic signals involved are BMP, Wnt, and FGF and intrinsic transcription factors like SoxB1 related genes. Secreted proteins such as BMP and its antagonist Noggin and chordin act permissively to establish the fate of neural tissue in the dorsal ectoderm and enables the formation of the neural plate.[11]