To reduce the risk of adverse events, high-potency glucocorticoid should not be applied on the face, intertriginous areas, areas with thin layers of skin (e.g. the perineum, armpit) in children.[21][22][23] Moreover, high-potency glucocorticoid should be applied to skin only once a day and should not be used for more than fourteen days.[24] Even low-potency topical glucocorticoids are able to cause adverse effects in children when used for prolonged periods of time.