Rodon signed for Premier League club Tottenham Hotspur on 16 October 2020 for a fee of around £11 million on a five-year contract.[6][7] Rodon made his Premier League debut for Tottenham Hotspur on 26 October 2020 after coming on as a substitute for Son Heung-min in the 93rd minute in the 1–0 win away against Burnley.[8] He made his first start for the club in the away match against Chelsea on 29 November as Toby Alderweireld was out injured, and helped keep a clean sheet in a 0–0 draw.[9][10]