Cagayan River, often called the Cagayan de Oro River, is one of the rivers draining the northern central part of the island of Mindanao in the Philippines. The river has its headwaters in the Kalatungan Mountain Range and Kitanglad Mountain Range found in the central part of the province of Bukidnon. It traverses the municipalities of Talakag, Baungon and Libona, connecting tributaries along the way.