Mature osteoblasts are differentiated precursor cells found in the bone marrow. MSCs are typically found in the bone marrow stroma.[33] MSC differentiation is induced by a cocktail of morphogens and other factors. Human MSCs have been shown to differentiate with a cocktail of dexamethasone, isobutyl methyl xanthine, insulin and rosiglitazone (a peroxisome proliferator-activated receptor γ2 (PPAR-γ2) agonist) in vitro.[31]