Some small studies have suggested that imipramine, clomipramine and taurine may be useful in the treatment of myotonia.[1] However, due to the weak evidence and potential side effects such as cardiac arrhythmias, these treatments are rarely used. A recent study in December 2015 showed that a common FDA approved antibiotic, Erythromycin reduced myotonia in mice.[20] Human studies are planned for erythromycin. Erythromycin has been used successfully in patients with gastric issues.[21]