The university was founded with the name "Collegio Cattolico della Santa Famiglia": the roots were in the 1941 "Scuola di Medicina", linked to the Asmara Hospital (then named "Regina Elena"). In the early years, the curriculum reflected Italian educational plans, and courses were taught in Italian with a view to preparing students to receive the "laurea" (degree) from a university in Italy. In 1958, members of the missionary congregation 'Piae Madres Nigritiae' or Comboni Sisters began private education classes for 10 Italian female students: the "Holy Family University Institute" was founded by the Italian Sister Marianora and Sister Fosca.