Tueni was assassinated by a car bomb on 12 December 2005 in Mkalles, an industrial suburb of Beirut, while he drove from his home in Beit Meri (Mount Lebanon) to his newspaper's offices in Beirut's Martyrs' Square.[3] Two of his bodyguards were also killed in the blast.[16] He was the seventh target in a series of assassinations of politicians, journalists and security personnel that had begun in Lebanon in 2005.[17]