The genes for the biosynthesis of PZN were first reported in 2008.[4] The natural product was then isolated in 2011 from Bacillus amyloliquefaciens.[5] The structure of PZN was solved later that year by two independent research groups, primarily through high-resolution mass spectrometry and NMR spectroscopy.[6][7] In 2013, various biomimetic chemical synthesis studies of PZN were reported, including a total synthesis.[8]