Tibet would be de facto independent from the mid-14th century on, for nearly 400 years.[48] In spite of the weakening of central authority, the neighbouring Ming Dynasty of China made little effort to impose direct rule, although it had nominal claims of the Tibetan territory by establishing the U-Tsang Regional Military Commission and Do-Kham Regional Military Commission in 1370s. They also kept friendly relations with some of the Buddhism religious leaders known as Princes of Dharma and granted some other titles to local leaders including the Grand Imperial Tutor.[49][50]