Khan lost in the 1954 East Bengali legislative election.[1] In 1962, he was elected uncontested a member of the National Assembly of Pakistan. He joined the cabinet led by President Ayub Khan becoming the Minister for Health, Labour and Social Welfare.[3] During his ministry, seven medical colleges were established in East Pakistan and MBBS condensed course for the LMF doctors was introduced and the Institute of Postgraduate Medicine and Research (now Bangabandhu Sheikh Mujib Medical University) was established.[3] After two months, on 28 October 1962, he was appointed as the governor of East Pakistan.[3]