Born into a tennis family where his mother was a professional on the Women's Tennis Association (WTA) tour and his father was trained as a tennis coach, Tsitsipas was introduced to the sport at age three and began taking lessons at age six. As a junior, he was ranked No. 1 in the world. He also became the third Greek player, and first Greek male in the Open Era, to win a junior Grand Slam title with a victory in the 2016 Wimbledon boys' doubles event.