For example, STAT1 can enable the transcription of genes which inhibit cell division and stimulate inflammation.[1] Also, STAT4 is able to activate NK cells (natural killer cells), and STAT5 can drive the formation of white blood cells.[2][21] In response to cytokines, such as IL-4, JAK-STAT signalling is also able to stimulate STAT6, which can promote B-cell proliferation, immune cell survival, and the production of an antibody called IgE.[2]