The surface area to volume ratio (SA:V) of a cell imposes upper limits on size, as the volume increases much faster than does the surface area, thus limiting the rate at which substances diffuse from the interior across the cell membrane to interstitial spaces or to other cells. Indeed, representing a cell as an idealized sphere of radius r, the volume and surface area are, respectively, V = (4/3)πr3 and SA = 4πr2. The resulting surface area to volume ratio is therefore 3/r.