SC Cambuur[2] (promoted after a five-year absence), Go Ahead Eagles and NEC Nijmegen (both promoted after a four-year absence) were promoted from the 2020–21 Eerste Divisie. ADO Den Haag (relegated after thirteen years in the top flight), VVV-Venlo (relegated after four years in the top flight) and FC Emmen (relegated after three years in the top flight) have been relegated to 2021–22 Eerste Divisie.