The altarpiece of the large chapel in the southern aisle enshrines the most celebrated art treasure of the church—a white marble sculpture of the Madonna and Child created by Michelangelo around 1504. Probably meant originally for Siena Cathedral, it was purchased in Italy by two Brugean merchants, the brothers Jan and Alexander Mouscron, and in 1514 donated to its present home. The sculpture was twice recovered after being looted by foreign occupiers—French revolutionaries c.