Numerous toxicology studies have been conducted over the past 40 years on PBO examining the full range of potential toxic effects.[12] These studies were conducted in accord with regulatory requirements put forth by the United States EPA or other international agencies. Many were conducted following United States EPA Good Laboratory Practices (GLPs), a system of processes and controls to ensure the consistency, integrity, quality, and reproducibility of laboratory studies conducted in support of pesticides registration. The following types of studies have been conducted in support of PBO registration: