The town was once the location of the Château d'Issy, destroyed in 1871, former home of the Princes of Conti. On 1 January 1860, the city of Paris was enlarged by annexing neighboring communes. On that occasion, about a third of the commune of Issy-les-Moulineaux was annexed to Paris, and forms now the neighborhood of Javel, in the 15th arrondissement of Paris.