However, in cases of low grade bacterial infections of bone and joints such as coagulase negative staphylococcus (CoNS), and systemic lupus erythematosus (SLE), ESR can be a good marker for the inflammation process. This could be due to the production of Interferon type I that inhibits the CRP production in liver cells during SLE. However, CRP is a better marker for other autoimmune diseases such as polymyalgia rheumatica, giant cell arteritis,[2] post-operative sepsis, and neonatal sepsis.