Following the withdrawal of the University's autonomy by the Communist state, it was placed under the strict central control of the Ministry of Health, which even prescribed the extent of its participation in regional medical care. Meanwhile, medical research was starting to involve increasingly expensive areas, which consequently resulted in the University's lagging behind the world's wealthier nations. To make matters worse, there was a political trend of reclusion in the 1950s, due to the exclusive Soviet influence.