His mechanical limbs use endorphins to counteract the pain of being attached to his body, which he enjoys. When he injures two muggers on a date, this horrifies Mary Jane and in the resulting battle with Spider-Man his tentacles are fused together, and the fusion begins to kill him. In the script, Octavius is the creator of the genetically-altered spider from the first film, and gives Peter an antidote to remove his powers: this means when Octavius is dying with his tentacles, he wants to extract Spider-Man's spine to save himself.