Type OMIM Gene Notes BrS1 601144 SCN5A NaV1.5 – α subunit of the cardiac sodium channel carrying the sodium current INa.[1] BrS2 611778 GPD1L Glycerol-3-phosphate dehydrogenase like peptide – reduced GPD1-L activity leads to phosphorylation of NaV1.5 and decreased INa.[6] BrS3 114205 CACNA1C CaV1.2 – α subunit of voltage-dependent calcium channel carrying the L-type calcium current ICa(L).