Indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist.[6][7] It has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor via its action as a serotonin releasing agent.[8][9][10] The drug has been found to possess nootropic,[11][12] neuroprotective,[13][14][15][16] anticonvulsant,[17] and antidepressant-like effects in animal models.[13][6]