Oxygen diffusion-enhancing compounds are thought to act by exerting hydrophobic forces that interact with water molecules.[9] These interactions result in greater hydrogen bonding among water molecules, which constitute the majority of the blood plasma medium.[9][10] As hydrogen bonding increases, the overall molecular structure of water in the plasma becomes more lattice-like, a phenomenon known as structure building.[11][12] Structure building reduces resistance to the movement of oxygen through plasma via diffusion.[11] Since blood plasma offers the major barrier for oxygen to move from the red blood cells and into the tissues,[5] the more structured character of water imparted by the oxygen diffusion-enhancing compound will enhance movement into tissues.[9][13]