Lueders began her NASA career in 1992[6] in the propulsion lab at the White Sands Test Facility. As only the second woman to work at the facility,[2] Lueders started as the depot manager of the Space Shuttle program Orbital Maneuvering System and Reaction Control Systems. She has also held several managerial positions within the International Space Station Program Office at NASA Johnson Space Center in Houston, Texas.[6]