Mirtazapine is considered to be relatively safe in the event of an overdose,[1] although it is considered slightly more toxic in overdose than most of the SSRIs (except citalopram).[53] Unlike the tricyclic antidepressants, mirtazapine showed no significant cardiovascular adverse effects at 7 to 22 times the maximum recommended dose.[3] Case reports of overdose with as much as 30 to 50 times the standard dose described the drug as relatively nontoxic, compared to tricyclic antidepressants.[54][55]