Ho joined Temasek Holdings as a Director in January 2002 and became its Executive Director in May 2002.[6] The then-chairman of Temasek Holdings, former Cabinet minister S. Dhanabalan, said Ho was the best person for the job because of "a willingness on her part to take calculated risks[7]". She assumed the role of Chief Executive Officer of Temasek on 1 January 2004.