After the annexation of Mari in the northwest and Ešnunna in the east, there was no buffer against the increasing power of the Hittite Empire and the Kassite tribes in the Zagros. It was impossible for the successors of Hammurabi to fight against all these enemies at the same time, and they started to lose their grip. These enemies sometimes invaded Babylonia, and in 1595 BCE the Hittite king Mursilis I advanced along the Euphrates, sacked Babylon, and even took away the statue of the supreme god of Babylonia, Marduk, from its temple, the Esagila.