The Isthmus Department, or Department of Panama (Spanish: Departamento de Panamá), was one of the departments of the Republic of Gran Colombia and later of the Republic of Colombia. It was created in 1824 and named after the Isthmus of Panama. It covered the territory of what is now the country of Panama and some coastal territories farther northward along the Caribbean shoreline of present-day Costa Rica and Nicaragua (Mosquito Coast).