In clinical pharmaceutical chemistry the aim is to understand biological transformations and processes associated with chemical entities inside the human body, and how those processes can be influenced with changes in chemical structures. The aim of clinical pharmaceutical chemistry is in addition to manage and manipulate clinical effects of different chemical structures, as well as to manage phenomena recognized in first-in-human studies. Typically clinical pharmaceutical chemistry has an important role in discovery, design and manipulation of new drug entities, and is vital especially in early clinical studies (such as Phase I studies).