The octanol-water partition coefficient (Kow) is correlated with the potential for a chemical to bioaccumulate in organisms; the BCF can be predicted from log Kow, via computer programs based on structure activity relationship (SAR) or through the linear equation:formula_2Where:formula_3 at equilibrium=== Fugacity capacity ===Fugacity and BCF relate to each other in the following equation:formula_4where ZFish is equal to the Fugacity capacity of a chemical in the fish, PFish is equal to the density of the fish (mass/length3), BCF is the partition coefficient between the fish and the water (length3/mass) and H is equal to the Henry's law constant (Length2/Time2)=== Regression equations for estimations in fish ===== Uses ===== Regulatory uses ===Through the use of the PBT Profiler and using criteria set forth by the United States Environmental Protection Agency under the Toxic Substances Control Act (TSCA), a substance is considered to be not bioaccumulative if it has a BCF less than 1000, bioaccumulative if it has a BCF from 1000–5000 and very bioaccumulative if it has a BCF greater than 5,000.