Given that a larger number of subjects or iterations enhances an experiment’s ability to detect all of the relevant effects, which bolsters confidence in the result, outcomes of small studies tend to imply significant uncertainty – unless the intervention’s effects are potent. Enrichment allows researchers to perform smaller, more informative trials by helping them to design studies that will show a high “relative treatment difference” between the drug and whatever it is being compared to (often a placebo, but sometimes another treatment).