Across the globe, the Southern Africa Development Community has set a goal of eliminating malaria from its four southernmost members – Botswana, Namibia, South Africa, and Swaziland – by 2015. To do so, they are in active discussions with their northern neighbors, and innovative cross-border collaborations are being developed, building on the model of the highly successful partnership between Mozambique, South Africa, and Swaziland.