Possible side effects of erythromycin are burning, redness or stinging of the eyes and blurred vision. If these symptoms persist and your condition does not improve, discontinue use of erythromycin and notify your physician as soon as possible. Erythromycin can also cause severe allergic reactions and you should discontinue use immediately if you notice the following symptoms:  Rash Hives Swelling Redness Chest tightness Difficulty breathing or wheezing Dizziness or lightheadedness Remove contact lenses and all eye makeup. Make sure that you have a mirror in front of you so you can see what you're doing or consider having a friend or family member help with application. . Always ensure that your hands are clean before using the ointment by washing them with soapy water. Washing your hands before touching your face and eyes can help to prevent further infection.  Ensure that you wash your hands thoroughly for at least twenty seconds with an emphasis on cleaning the areas in-between your fingers and under your fingernails.  Use warm running water and soap.

Summary:
Educate yourself about the possible side effects. Prepare to apply the medication. Wash your hands