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Once people drinking alcohol begin to show signs of physical impairment, first get them to stop drinking any more alcohol. Some beginning signs of physical impairment are slurred speech, slow or clumsy movements, swaying, dropping objects (e.g., goods, money, keys) or forgetting thoughts in mid-sentence.  To get someone to stop drinking, try talking to them calmly as a friend. Tell them that you think they may have had too much to drink and that you are worried, so it would make you feel better if they would quit drinking for the night. Appeal to their sense of friendship if you have to — that they are doing you a favour by not drinking anymore. If they refuse to quit drinking, consider taking more drastic measures. If you are in a bar, tell the bartender that you think the intoxicated person has been drinking too much and ask the bartender to quit serving them alcohol. If you are in a private space like a house, try to hide all the remaining alcohol. The drunk person will not be as observant as usual because of their dulled senses, so it should be relatively easy for you to hide the alcohol without them noticing. If a person shows a loss of motor control, function or poor coordination, they must not be left alone as they could become a danger to themselves or others. Stumbling or swaying, having difficulty with depth perception, and dropping things repeatedly or having difficulty picking them up are signs that the person has progressed to this level. If you notice someone is very intoxicated and they are in a public place like a bar or restaurant, try to help them get home so he can go to bed and sleep it off. You can offer the person a ride yourself, call a cab for them, offer to call a friend, or call a drunk ride service if one is available in your area. Drinking and driving is extremely dangerous — to the drunk driver themselves and to everyone who crosses paths with them. Sometimes people make poor decisions when they have had too much to drink, or aren’t able to correctly gauge their own level of drunkenness, so they choose to drive when they shouldn’t. To prevent someone from driving drunk you can try helping them get home another way, by notifying the bartender or the police, or even by stealing their car keys. People can be a danger to themselves when they are intoxicated. This is especially true if the intoxicated person is well past the point of minor drunkenness. There are many dangers to be considered — for example, people have been known to die from choking on their own vomit while they were intoxicated. So if you help someone who is drunk get home, try to make sure they are sleeping on their side so they won’t be able to choke if the person ends up vomiting. If you see a person who is heavily intoxicated but this seems to be out of character for them, or notice they only had a single drink, it is possible that they have been roofied. This means that someone has slipped a drug in their drink (usually the sedative Rohypnol) that will cause them to lose some muscle control and, in effect, be unable to resist if he is assaulted. Alcohol poisoning is a very serious condition that results from drinking more alcohol than your body can handle. In a worst case scenario, this can result in death. If you think someone you know has alcohol poisoning, seek emergency medical attention immediately. These are some symptoms of alcohol poisoning:  Vomiting Seizures Confusion Slowed breathing Passing out Pale skin There are a number of different medical conditions which may cause a person to appear drunk. For instance, someone suffering a stroke may have a drooping face, slurred speech, confusion, dizziness, difficulty walking, and so on.  If the person displays symptoms of being drunk but has not been drinking, these signs appear out of nowhere, or you are simply unsure, you can perform a few simple tests to see if the person is having a stroke. Ask them to smile, to raise both arms over their head, and to speak a simple sentence. If part of the person's face droops or their smile is asymmetrical, if one arm seems to drift downward, and/or if they cannot repeat the sentence or seems to be searching for words, they may be having a stroke and needs emergency medical assistance. A person with diabetes may display what could be interpreted as "drunk behaviour" when they are, in fact, experiencing ketoacidosis, which occurs when the body doesn't have enough insulin and there is a build up of acids called ketones in the bloodstream. If you also notice the person has fruity-smelling breath and they have not been drinking fruit-flavoured drinks, they may be experiencing ketoacidosis and needs immediate medical help.  Disorders like Parkinson’s disease, multiple sclerosis and ataxia all affect movement and may cause a person to appear drunk or have difficulty maintaining their balance. Don't assume that someone who has difficulty keeping their balance is intoxicated.

Summary:
Try to get the person to stop drinking. Keep them company. Get the person home. Prevent the person from driving. Make sure the person is safe. Seek medical attention if you think the person has alcohol poisoning. Keep other causes in mind.