Summarize this article:

Only switch the hammer to a full cock position when you are ready to fire.  If you do not plan to fire the revolver immediately, then you should rest it over the empty chamber of the gun. If no chamber has been left empty, then rest it on a safety notch in between two nipples or on a safety pin. Note that it is not safe to carry the revolver with the hammer in its half cocked position over a loaded chamber. Aim the gun down range at a safe target. Pull the trigger to fire the revolver.  You should be able to continue firing until all of the chambers have been emptied. Keep count of your shots as you fire. Make sure that all of your shots have fired before you set the gun down or reload it. Wait at least one minute before reloading the revolver. Doing so allows any remaining sparks to burn out. When the revolver is ready to reload, you can reload it by following the same procedure outlined in the "Loading the Revolver" section.

Summary:
Fully cock the hammer. Aim and fire. Wait one minute before reloading.