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Start by stripping the bed of any sheets, blankets, or duvets. Put the bedding in the washing machine and clean them with detergent on the hottest water setting to kill germs. You should then dry them on the high heat setting to ensure there are no germs or bacteria on them. Use the upholstery attachment on your vacuum or a powerful handheld vacuum. Make sure the nozzle is clean, as you do not want to transfer any debris onto the mattress. Vacuum the crevices, seams, and folds in the mattress to remove any surface dirt or dust. Make sure you also vacuum the sides of the mattress, as dirt and dust can collect in this area as well. Use upholstery cleaner or make your own by mixing 1 teaspoon (4.9 ml) mild dish detergent and 1 cup (240 ml) of water in a spray bottle. Apply the spot cleaner to any stains and dab the area with a wet cloth. Most stains that are protein-based, like sweat, urine, and blood, should come off with a regular spot cleaner. Stains like red wine or coffee may be more difficult to remove and require stronger spot cleaner.

Summary:
Remove the bedsheets and wash them in the washing machine. Vacuum up any dirt, dust, or debris on the surface of the mattress. Apply spot cleaner on any stains on the mattress.