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Before you can start installing the acrylic print with standoff bolts, decide where you'd like to place it on the wall. If the acrylic print is large, have someone help you. Position the acrylic print on the wall where you'd like it to be placed and use a level to make sure all of the sides are even. For large prints, have the second person hold the acrylic print up against the wall while you use the level, or vice versa. When you order an acrylic print from a company, they should have drilled holes into the acrylic print in each of the corners for you. After the print is positioned on the wall, use a pencil to trace the edges of each pre-drilled hole so that you'll know where to place the anchors. You should end up with 4 circles on the wall.  If you're installing a large acrylic print, have one person hold the print up against the wall while you trace the holes. You can put the acrylic print down once you've finished tracing the holes. The circles that you outlined are where you'll place each anchor. Use a drill to drill in each anchor, making sure they're flush against the wall. If your acrylic print didn't come with anchors, you can purchase drywall anchors at a home improvement store or online. Standoff bolts come in 2 main pieces. Unscrew the standoff cover and set it down for safe keeping — this is the smaller of the 2 main pieces. Take the base of the standoff bolt, or the larger piece, and put a wall screw through it so that it's ready to be installed into the wall. Standoff bolts should come with your acrylic print if you ordered this type of installment. Position the base of the standoff against the wall, right on top of the anchor. Using the wall screw that you slid through the base, drill the base into the wall. Make sure that it's nice and tight against the wall so that it can support the weight of the acrylic print. Repeat this process with all of the other standoff bases, making sure they're all drilled into the wall snugly. Position the acrylic print onto the wall, lining up the bolts where the pre-drilled holes are in the acrylic print. Have someone else hold the acrylic print on the wall so that you're free to attach the covers, or vice versa. The standoff bolts should come with slim, clear protective washers. Place those on the standoff caps before screwing them into the bases. When screwing in the caps, don't tighten them completely. Use a level to make sure that your acrylic print is straight, and make any necessary adjustments. Once you're satisfied with the position of the print, tighten the standoff caps so that they won't come undone.

Summary:
Position the acrylic print on the wall and make sure it's level. Mark the 4 pre-drilled holes using a pencil. Drill the anchors into the wall where the circles are drawn. Unscrew the standoff bolt and slide the wall screw through the base. Use a drill to attach the standoff bolt to the wall. Place the acrylic print on the wall using the bases to line it up. Put on the protective washers and screw the caps into the bases. Check to make sure the print is level and tighten the caps.