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Purchase an appropriate enema. Use the correct, lubricated syringe. Prepare your environment and materials.

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The best kind of enemas are specifically prepared for cats. These contain dioctyl sodium sulfosuccinate in glycerine like Feline Pet-Ema ®. The dioctyl sodium sulfosuccinate draws water into the feces causing it to soften. The glycerin portion helps in lubricating the rectum. You can easily find cat enemas for sale online.  Alternatively, consider using warm water or mineral oil. You can also use warm water or mineral oil. Warm clean water is the cheapest and safest option since it's not likely to cause dehydration. Mineral oil is also relatively safe, can easily lubricate the rectum, and help small hardened stools pass. But, it can affect levels of fat soluble vitamins (like vitamin D) and should be avoided in cats with underlying kidney disease. If you use water or mineral oil, know that it can take time before the stool softens since it does not draw water from the intestines like sodium-based enemas do. It also lacks lubricating properties. Expect it to take several flushes into the rectum before the feces softens and slowly comes out (from a few minutes to 2 hours).  Never use Fleet enemas or any other enema containing sodium phosphate. Cats can absorb sodium and phosphate molecules from these enemas into their blood and tissues. This can lead to a severe electrolyte imbalance and dehydration, which could be life-threatening. If you're purchasing a prepared enema kit, it will come with the correct syringe. If you are using water or mineral oil as an enema, use a 10-25 mL syringe and a soft feeding tube attached to its end. The tips of feeding tubes are rounded, soft and can prevent damage during insertion. Always lubricate the end of the syringe or feeding tube. Place a light coating of lubricant (like KY Jelly or Vaseline) on the end of the syringe or feeding tube. Your bathroom is a great place to do enemas because your cat is familiar with the place, it is enclosed, and the cleaning will be confined to a small place afterwards. Clean all the surfaces and assemble your materials. An enema can be a messy procedure. You may want to lay out some towels, absorbent pads, or newspaper on the bathroom floor. You'll be best off wearing clean, plastic gloves. It's important that this process is hygienic for you, too.