Article: Traffic in San Francisco can be pretty bad at peak times, so try to plan your departure around it. To do that, you’ll want to leave very early - around 6:00 am - or later, between 10:00 am and 3:00 pm.  There might be traffic on the weekends as well, but it will be harder to predict. Check for real-time traffic reports online or tune into a TV or radio station report for an update before you leave. This will tell you exactly how to get onto the Golden Gate Bridge and which exit to take to get to your specific hotel or winery in Napa. You can also ask a friend or hotel concierge for specific directions. Use an app that contains traffic information so that you can avoid major backups. The easiest way to drive from San Francisco to Napa is also one of the most scenic. You’ll get to take the US 101 freeway across the famous Golden Gate Bridge, enjoying beautiful views across the San Francisco Bay. Try to avoid taking the bridge from 4:00 pm to 6:00 pm, which is when traffic gets the most congested. Use Exit 460A and follow signs for Napa/Vallejo. Hwy 121 will turn into Hwy 12, skirting the southern edge of Sonoma. Continue until it forks, taking the Hwy 121 exit. And continuing north towards Napa. Hwy 29 travels straight along the four main towns in Napa. Take the turn-off for the town you’re visiting or staying in and enjoy your day in Napa!
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Leave before or after rush hour on a weekday. Plot out your trip on a map or GPS device. Take the Golden Gate Bridge north. Connect from US Hwy 101 to CA Hwy 37 East. Continue east on Hwy 37 until turning off on CA Hwy 121. Turn left onto CA Hwy 29 to arrive in Napa Valley.