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Many experts on dog behavior recommend that a dog be exercised before travelling, or before being engaged in any activity that might get the dog restless and agitated. A well-exercised dog will be very inclined to rest because it has burned off its excess energy. Therefore, it's a good idea to schedule a brisk 30-minute walk before taking off. Your dog’s favorite blanket or toys contain a lot of familiar scents, and will reduce anxiety when the dog is brought to an unfamiliar place. Supplements containing casein, a protein found in milk, may be calming for some dogs. Try a supplement such as Zylkene if you want to try a gentle, natural approach to soothing anxiety.These supplements come in a variety of forms, such as capsules and chews. Studies have shown that pheromones are present in all mammals during the nursing stage. In dogs, this is the hormone secreted by the puppies’ mother, so when the puppies smell this hormone it calms them and reassures them that mom is around.  Examples of products that contain this hormone are: Adaptil® collar and spray, Sentry® Calming collar, and Comfort Zone® Diffuser with Dog Appeasing Pheromone. These products are very easy to use. The collars are simply placed on the dog’s neck to provide a sustained release of the pheromone which lasts for a month. Diffusers are simply plugged into a socket, and the pheromone is slowly and continuously released for a month. This type of product is ideal for rooms. Spray preparations can be used to spray cages, cars, or any carrier where the dog is placed. Melatonin is a hormone produced by the pineal gland. It is a sleeping hormone that causes the animal to have a good rest at night. It has a seasonal variation in animals and humans, increasing when there are fewer hours of daylight in winter.  Melatonin has sedative and anticonvulsant properties, and it regulates body rhythms and reproductive cycles. It is mainly used in the treatment of separation anxiety in dogs, and other stressful or frightening conditions like noise anxieties brought about by fireworks or thunder storms. Give this drug to your dog before travelling and/or before introducing your dog to a potentially frightening situation. An example of a product containing Melatonin is K9 Choice ™ Melatonin 3 mg tablets. The dose is 3 mg for every 35–100 pounds (16–45 kg) body weight, twice a day. For smaller dogs below 35 pounds (16 kg), the dose is 1.5 mg of melatonin, and for larger dogs greater than 100 pounds (45 kg), the dose is 6 mg twice times a day. Herbal pills and oils prepared specifically for dogs are commercially available. Examples include Dorwest Herbs™ Scullcap and Valerian tablets. This herbal medicine preparation can be used for the relief of anxiety, restlessness, excitability, and travel behavioral problems, and can even be used as a supporting supplement for epilepsy. It has been proven effective in dogs with noise phobias, travel anxiety, and hyperactivity.  Skullcap and Valerian Tablets are safe for long term and short term use and can be given from 2 months of age onwards. The dose for Dorwest Herbs™ Scullcap and Valerian tablets is 1 to 2 tablets per 5 kilograms (11 lb) of body weight daily. For one off occasions, use 2 tablets per 5 kilograms (11 lb) of body weight 12 hours before and again 2 hours before the desired effect is required. Skullcap and valerian are not recommended for pregnant or lactating females. Vetzyme Stay Calm Liquid®: this herbal oil is composed of a unique blend of chamomile and ginger oils. Research has shown that these 2 herbs posses calming, soothing, and relaxing properties. The dose is 2.5 millilitres (0.51  tsp) of the oil mixed into the dog’s food daily. Do this by mixing 1 teaspoon each of German chamomile, skullcap and catnip. Place these in a cup and set aside.  Heat .5 cups (120 mL) of water to boiling and pour this over the cup of herbs. Leave and let it steep for 6 minutes, then strain the liquid and pour 3 tablespoons (44 mL) of honey into the concoction. Store the mixture at room temperature for 24 hours before giving it to the dog.

Summary:
Make sure your dog gets plenty of exercise. Bring your dog’s favorite toys, blanket or rug when travelling. Offer your dog a casein supplement. Use products that contain appeasing pheromones. Use melatonin supplements. Try calming herbal agents. Prepare your own herbal concoction.