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Wait for the length of time specified by the instructions.

Article:
Depilatory creams usually work in 10 minutes or less, but it’s always good to check the instructions for the one you’re using.  Wipe off the cream immediately if you experience a burning sensation. Any pain means you’ve left the product on too long or your skin is too sensitive.  You may want to do an allergy test 24 hours before you intend to use the depilatory cream. Put a small amount of the cream on your forearm for the length of time recommended by the instructions. Remove and check for any redness. Do not use the cream if you have a reaction.