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Diatomaceous earth is an effective way to kill ladybugs before they can enter your garden. Wear goggles and a face mask, and generously spread the diatomaceous earth around each garden bed. You can also sprinkle diatomaceous earth around the outside of your house to prevent ladybugs getting inside.  Diatomaceous earth is safe for pets and children. However, it will kill other beneficial insects like honeybees. The goggles and face mask are only to prevent the powder being inhaled as it settles. Once it has settled, you can remove your safety gear. Deterring ladybugs from getting into your plants and home may be as simple as doing some gardening! Include plenty of mums in your garden, as these plants repel ladybugs. These protect neighboring plants and also deter ladybugs from entering your home through any doors or windows that are close by. Either plant the mums in the ground or in gardening pots and water them regularly to help them thrive. If the ladybugs in the garden are unmanageable, then an outdoor insecticide is an effective solution. Find an outdoor insecticide at your local gardening center and follow the manufacturer’s directions closely to apply it. Check the label before you begin to make sure that it's safe for any specific plants you may have, pets, and children.  Outdoor insecticides are commonly sold as either dusts, powders, or sprays. Always use gloves, a face mask, and goggles when applying outdoor insecticides.

Summary:
Sprinkle diatomaceous earth around the yard or garden perimeter. Plant Mums around your yard or garden to repel ladybugs. Use an outdoor insecticide if the infestation is difficult to control.