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One of the biggest advantages of running in place is that it doesn’t require much space—in fact, you really only need to be able to take 1-2 steps in a single direction! Once you’ve found a satisfactory place to post up, clear the area of any nearby furniture or other objects to free up enough room to move comfortably.  For maximum comfort and ease, choose a space that’s about one-and-a-half times as wide as your own body from shoulder to shoulder. An uncluttered garage, basement, workshop, or game room can work well for this purpose. Before you jump right into your workout, take a few minutes to loosen up your muscles and joints and get your blood pumping. A few rounds of high knees, deep lunges and dynamic stretches like swing kicks and hip rotations will help prepare your body for the more demanding activity to come.  Your warmup should last at least 5-10 minutes, and target every part of your body you’ll be using during your run.  An intelligent warmup routine will improve your performance and help prevent injury. Running in place isn’t much different from running normally—simply root yourself in place and begin pumping your legs up and down. Land lightly on the balls of your feet with each step, and don’t forget to keep your arms moving to steady yourself, as well.  Face forward and stay tall throughout your run. Try not to let your shoulders slouch or your head drop toward your chest. Even though you’re not covering any ground, it’s still important to be mindful of your form in order to avoid picking up bad habits. If you get tired of shuffling along in the same manner after a while, you can make things more interesting by modifying your technique to change direction. Take high, leaping steps every now and then like you’re attempting to clear a low obstacle, or bound from side to side as though you were running tires. Be careful not to get your feet crossed up while playing around with your footwork. Take things up to the next level by increasing your speed or lifting your knees higher and higher with each step. You could also try pausing periodically to work in some squats, tuck jumps, or other bodyweight resistance exercises. Any variation that makes your run harder will give you more bang for your buck.  Pick up a pair of light dumbbells to turn your run into a total-body workout. Just remember to take a break after a minute or 2 so that you don't strain your shoulder.  Limit difficult movements to short bursts to avoid tiring yourself out too fast. For instance, you might run normally for 2-3 minutes, then break into a “sprint” for 30 seconds before returning to a normal pace.

Summary:
Pick out a suitable spot. Warm up with a few active movements. Focus on proper form. Switch up your pattern of movement. Increase your intensity.