And notice it is not phosphorylated. But under certain conditions we have a kinase that is actually attached onto the e two component of the complex. This kinase is stimulated and we'll see what stimulates it. In just a moment, it is stimulated to transfer a phosphoryl group from ADP from ATP onto the e one component of the complex and that essentially forms this phosphorylated state and that inactivates the activity of e one. So remember, the e one component of the complex actually catalyzes step one and step two of Pyruvate decarboxylation. It essentially stimulates the e one, stimulates oxidative decarboxylation of Pyruvate into that acetyl component to ultimately form that acetyl coenzyme A.