And in this inactive form, both of these active sites are basically occupied by regions of the regulatory subunits. And the sequence of amino acids found on the regulatory subunit that binds onto the active side is known as the pseudosubstrate sequence. So in this R two C two complex it's the pseudosubstrate sequence of the R subunits that binds onto the active side and occupies that active side. And because that active side is occupied, it cannot bind to substrate molecules and so it is not active. But if our concentration of cyclic Amp inside our body begins to increase, what happens is those CMP molecules will begin to bind onto these allosteric sites. And once bound to all four allosteric sites, that creates conformational changes that causes these pseudosubra sequences to dissociate from the active sites and that produces this R two complex.