And as we increase the concentration of glucose six phosphate due to the inhibition of PFK, that increase in concentration will inhibit the hexokinase. And this same exact regulatory mode is actually used by skeleton muscles as well. So just as in skeleton muscle cells, glucosex phosphate is also an allosteric inhibitor to hexokinase. And this is the process that allows the phosphor fructokinase to actually communicate with the hexokinase and essentially tell it to turn off that first step in glycolysis. And once these two irreversible steps are essentially turned off, that greatly diminishes the rate at which the glycolytic pathway actually takes place. Now, there is one important difference between hexokinases in liver cells and hexokinases in skeletal muscle cells.