So carbon monoxide, as it turns out, is actually a competitive inhibitor of hemoglobin, and it competes with oxygen. And in fact, it is 250 times more likely to actually bind to the heme group of hemoglobin than oxygen. Now, by binding to hemoglobin, the carbon monoxide creates a conformational change that ultimately increases the affinity of hemoglobin for oxygen. It makes hemoglobin much more likely to bind oxygen. And what that means is, by binding to our hemoglobin Co, carbon monoxide ultimately causes the hemoglobin to not be that likely to release oxygen to the tissues. And so, as a result, the tissues will receive less oxygen.