And that in turn amplifies how much of the blood clots we actually can form, how many of the blood clots we can form. So two important functions of factba eight. Factba eight interacts with proteolytic enzyme factor nine and stimulates it to basically go on and activate factor X, which is needed to ultimately coagulate the blood and form the blood clots because it's this molecule, factor X, that initiates the final common pathway that is used to form those blood clots. And the second important function of factor eight is thrombin creates a positive feedback loop, stimulating factor eight, swimming around in the blood to interact with factor nine, which causes an amplification effect. And this is basically this positive feedback loop that I just discussed just a moment ago. So we basically see that in individuals with classic hemophilia, there is some type of mutation.