So this is the hemoglobin, this is the beta one, beta two, and these are the alpha subunits. And if we examine at the corners of these two beta subunits, there are these residues that carry positive charges. And these positive charges basically repel one another. And this destabilizes the T state of that deoxy hemoglobin. Now, what does this actually mean physiologically? Well, if the T state is destabilized, there's only one thing that the deoxy hemoglobin molecule can do.