They can use water to hydrolyze those bonds, releasing that inorganic phosphate and reforming this initial state of the molecule. And so in this state, the enzyme is active and can catalyze Pyruvate decarboxylation. So we see that the complex basically moves back and forth between the active and the inactive state. And this is the major method by which the cells of our body actually regulate pyruvate carboxylation and in turn regulate the citric acid cycle. Now, what types of conditions actually favor this state and what types of conditions actually favor this state? So let's suppose we're in a skeleton muscle cell and in that skeleton muscle cells we are at a resting condition.