And what that means is we have to input a lot of energy to actually overcome this reverse activation barrier. And we simply don't have that much energy under normal conditions inside our cells at a PH of seven and at the normal body temperature, we don't have enough energy for this reaction to actually take place. In fact, to actually break the peptide bond inside our body, we have to use special enzymes that basically decrease this activation barrier. So once again, if the dipeptide bond, if the dipeptide formation as described in this diagram is energetically unfavorable, why doesn't the reverse reaction take place spontaneously? And naturally in our body. Well it turns out that the activation energy is simply too high, it's simply too great.