And in this reaction, that enzyme, when the substrate is inside the active side, the enzyme will catalyze the transformation of the substrate into the product and we form our product and the product dissociates from the active side. And the rate constant of this reaction is given by k two. Now, let's focus on just this reaction here. So in this reaction, we essentially have a certain rate law. And the rate law, the expression that describes the rate at which this reaction takes place is given by this equation here. So the V knot, the rate at which the enzyme catalyzes this reaction, is equal to the product of the rate constant, k two, and the concentration of the enzyme substrate complex Es.