So, if we begin with glutamate, glutamate can simply be metabolized directly into alpha key gluterate. But if we have either one of these four amino acids shown here, they must first be metabolized into glutamate, and then glutrimate is in turn metabolized into alpha ketoglutrate. So this is the strategy that our cells employ. So let's take a look at how glutamate can be transformed into alpha ketoguterate. So what's the difference between glutamates and alpha ketoglutrates? Well, on the glutamate, we have this alpha amino group, but on the alpha ketoglutrate, we don't.