So on top of increasing the levels of H plus ions in the blood and tissues, we're going to increase the amount of water that we release by the kidneys. So we essentially decrease the volume because we decrease the water concept in the blood, we increase the concentration of H plus ions in the blood. And what that does is it causes severe Ketoacidosis. And so this can basically damage tissues and cells of our body. For example, it can damage the central nervous tissue, the central nervous cells. And so we see that it's very important for type one diabetics to actually regulate their insulin, because if they don't regulate their insulin, they're going to basically get Ketoacidosis, which can be very damaging to the tissues.