And this also helps prevent unwanted reactions. Now, property number four of active sites active sites actually only make up a very small portion, a very small component of that overall enzyme. So even though the enzyme is usually relatively large. That active side is actually quite small compared to the overall structure and size of that particular enzyme. The question is why? Well, if we examine the residues involved in the active side, those residues are usually found very far away, apart from one another on that primary sequence of the polypeptide chain.