But if we have high levels of isocitrate, we're also going to see an accumulation of citrate molecules and this will promote fatty acid synthesis. So high levels of ATP and high levels of citrate molecules basically stimulates the process of fatty acid synthesis. And that makes sense because we need ATP and we need citrate to actually begin the process of fatty acid synthesis. So once again, what actually promotes what stimulates fatty acid synthesis? Well, when the level of ATP in the matrix is high, this means that we no longer need to actually synthesize any more ATP. And therefore the ATP will create a negative feedback loop that will inhibit isocitrate dehydrogenase.