These hydrolytic enzyme, hydrolytic enzymes basically end up being transported out of the cell. And so in individuals with the eye cell disease will have a high concentration of these hydrolytic enzymes in our blood plasma, and the lysosomes are going to be deficient in these hydrolytic enzymes. And what happens if we don't have the hydrolytic enzymes inside the lysosomes? That means we're going to have an accumulation of all these different types of byproducts inside the lysosomes. So things like glyco, lipids and large carbohydrates and glycosaminoglycans will not be able to be broken down because of the absence of these hydrolytic enzymes. And that can lead to many, many negative problems inside our cells and inside our body.