Now we want to activate this molecule and so what our body does is when there is a rise in glucose levels in our blood that causes the uptake of glucose into the liver cells. And so the cytoplasmic glucose concentration increases within the liver cells following the ingestion of the meal that is rich in carbohydrates. And these phosphorlase A molecules basically serve as glucose sensors because they're able to actually bind the glucose molecule. So we have these two pockets on the phosphorlase A in the r state that can bind the glucose. And once the glucose is bound to these two sections, that causes the transformation of the phosphorase A in the R state, the active state into the inactive T state. So the glucose bind onto phosphorlase A.