Now, because of the instability of this intermediate, a special pocket, a special region on the Chimotryptin enzyme known as the oxyanion hole or oxyanine pocket, basically interacts with the negative charge on this oxygen. So inside the pocket we have these nitrogen atoms that contain H atoms. And these partially positive H atoms can interact with the fully negative oxygen atom. And so what the oxygenine nine hole does is it stabilizes this tetrahedral intermediate. Now, because of the instability of the tetrahedral intermediate, it's not going to exist for a very long time. And what that means is it's going to very quickly collapse.