So we see that although this reaction is thermodynamically favorable, it occurs at an extremely slow rate. And this has to do with the double bond character of peptide bonds. In this diagram we see that the resonance stabilized structure of peptide bonds make the carbon, this carbon here less susceptible to nucleophilic attack by water. Because of this resonance stabilization, the electrons fluctuate around the carbon and nitrogen as a result of the double bond character and that essentially electrostatically repels the electrons of that water molecule. And therefore in order for this reaction to actually take place at a high enough rate inside our body and in order for us to be able to quickly and effectively break down these peptide bonds we have to use these enzymes, these proteases. Proteases.