But also nearby alpha domains on other structures, on other seven TM domains will also expel that GDP and bind the GTP. So a single Epinephrine can cause many G proteins to exchange the GTP for the GDP and this causes an Amplification effect. This is the first level of Amplification. The second level will discuss in just a moment. So once this takes place, once the Epinephrine binds onto its side, it causes a conformational change that allows this structure to expel that GDP and instead of that, basically bind the GTP and that decreases the affinity of this G alpha protein to this structure and this dimer. And so they dissociate.