Well, the partial answer is the following because our cells begin to respond and they respond by producing a factor known as Hypoxia inducing transcription factor which is HIF One. Now, what exactly is the function of the Hypoxia inducing transcription factor? So as the name implies, what it does is it essentially affects transcription, it essentially affects the expression of specific genes. Now, what genes with this transcription factor actually affect? Well, it's the genes that code for proteins and enzymes involved in actually breaking down that glucose and uptaking the glucose into the cell. So things like glucose transporters and enzymes involved in Glycolysis are actually stimulated.