So this will be the topic of this lecture. Now, what exactly is renal clearance? Well, renal clearance of a given and substance basically tells us how much volume of blood plasma is completely cleared of that substance over some time period by our kidneys. And the units of renal clearance are milliliters the volume per minute, our time. So let's begin by taking a look at the simplified diagram of our nephron, the basic functional unit of our kidney. So we have the apharyine arterial that brings our blood vessels, that brings the blood plasma into the network of capillaries found inside the bow, its capsule known as the glomerylus.