Now, when our blood pressure increases, when our blood volume increases, the increase in the blood volume can basically create a negative feedback loop and that will basically go on and cause our Rena to stop being secreted by the kidney. So let's take a look at the following diagram that basically describe summarizes the renal angiotestin aldosterone system. So let's suppose inside our blood, we have a low volume of blood plasma, we have low blood pressure, and that means we have a low profusion rate inside our kidneys. So this will basically cause special types of cells, known as juxtaglomeroth cells inside the kidneys to release our enzyme known as Rena. And at the same time, liver cells produce and release a zymogen known as angiotensinogen into the bloodstream. And when these two mix, the Renan will basically cleave our angiotensinogen and form angiotensin one.