So ultimately this structure as well as this structure go on to basically initiate many different types of cell processes that ultimately create that physiological effect. And in the instance, in the case of angiotensin two receptor, that final physiological effect is the increase or the decrease in the blood pressure in the cardiovascular system. So this is what the phosphorotide signaling pathway actually does. So once again, let's quickly review this pathway. So the first step is the binding of the primary messenger to the active side, not the active site, the location on that protein. And when that takes place, it initiates the removal of the GDP from this G protein and this GTP replaces it.