But let's imagine that's phosphoride cascade. We discussed three different types of secondary mastery molecules. So we looked at IP Three, we looked at Dag, and we also looked at calcium. So we said that IP Three has to bind onto a calcium channel in the Er membrane to allow the calcium to move into the cytoplasm. And then the calcium, with the help of dad, must bind onto a special protein we call protein kinased and that activates protein kinase C. On top of that, calcium also actually goes on to bind to calm modulin to form the calcium calmodulent complex, which then which then goes on to activate those calamodulin dependent protein kinases. In the case of insulin signaling, we discussed how for the Pip Three dependent protein to actually begin to actually be able to activate protein kinase B, that Pip Three dependent protein kinase must actually bind Pip Three.