Remember, we have two beta chains in a single hemoglobin molecules, and both of those chains will have that abnormality. So glutamate at the 6th position is substituted to the valley in that same position. So in normal hemoglobin, glutamate six is a polar molecule, and normally it points to the surface, to the outside of the blood plasma. Now, blood plasma consists predominantly of water molecules, and water is polar. And because glutamate is polar, glutamate has no problem interacting with the water molecules. And so that creates no problem because that glutamate would much rather interact with the polar molecules than any other nonpolar molecule.