And this only happens after we actually eat a meal rich in carbohydrate, so after we eat that carbohydrate rich meal, the blood glucose levels will rise. And that will allow these glue too to actually sense that increase in glucose levels, because they have a km value that is high, so they're not as effective in binding the glucose as these two other molecules. And that's important, because they don't need to be effective, because it's the brain cells and muscle cells of our body that need that glucose more than the liver cells. And so once we eat, it's these liver cells that begin to secrete the insulin. And the insulin, as we'll see in just a moment, actually goes on and affects glute four. So let's finish with glute two.