So we suppose that the enzyme substrate complex dissociates into E and S much more rapidly and much more readily than E into P. And what this basically implies is the value of K two is much smaller than the value of K minus one. Because if this rate is much greater, that implies that K minus one must be much greater than K two. And if K minus one is assumed to be much larger than K two we can simplify this equation in the following way. So the MCA les constant Km is equal to so K minus one plus K two divided by K one. And because K minus one this quantity is much greater than K two. For example, let's say if this is 1 million and this is one, then 1 million plus one doesn't really change the value of K minus one by too much.