So let's suppose our pathogen makes its way into our tissues and releases its pathogenic antigen. Now, at this particular moment in time, we have never actually seen our immune system has never actually seen this particular antigen. And what that means is we're going to have no corresponding antibodies in our body, in our blood, that can actually bind to that particular antigen. So at least in the beginning, our concentration of antibody that is specific for that antigen will be zero. Now, right away when we're infected, the innate immune system kicks in and we can have the process of inflammation take place that essentially prevents that infection from spreading to other parts of our body. But our adaptive immune system will actually take time to take into effect.