So we conclude that the second meaning of the Michelis constant, as long as we make the assumption that K minus one is much greater than K two, so this reaction is much quicker than this reaction. We basically see that the Michaelis constant describes the likelihood of the dissociation of the substrate from the active side of that enzyme. So we see that if the Km value is very large, then that means our numerator term in the ratio is much greater than our denominated term. And if the numerator term is large compared to our denominator, that means we have a high concentration of the enzyme and the substrate in its dissociated form. And that implies that the substrate does not bind very strongly to the active side of that enzyme. So we see that if Km is large, the enzyme binds weakly to the substrate and there is a high probability that the substrate will dissociate from the active site of the enzyme because Km describes the equilibrium constant.