And what that means is the entire coronary structure is constrained. And so the affinity of the heme groups for oxygen is very low. And in the same analogous way, because this allosteric enzyme basically exhibits cooperativity. It also exists in the T state as well as in the r state. So when the polyme molecule E is absent from the environment, that means none of the active sites are actually occupied. And so the entire coordinary structure of this enzyme will exist in the T state.