So let's begin with injection with the micro pipette. So we essentially have this very, very small instrument called a micro pipette that contains a very small diameter. And we can essentially hold the nucleus of the cell. So let's suppose this is the nucleus of our mouse cell. We can hold the nucleus on one end with some type of instrument, for example a larger pipet, we can hold this in place while at the other end we poke with a special type of micropipet that contains that DNA fragment that we want to inject. And so by injecting this nucleus of the cell can essentially accept and incorporate that DNA molecule into its genome.