So the tyrosine kinase receptors like the EGF receptor here, if the cell actually builds too many of these proteins and inserts too many of these proteins into the membrane of that cell, what that will do is increase the likelihood that the cell will activate the pathway at an inappropriate time. And so this access number, the excess amount of these receptors, the access amount of these receptors in a cell membrane can basically lead to the production of these cancer cells. So, overexpression of tyrosine kinase receptors can also lead to cancer of the epithelial cells. For instance, we have cancers like breast cancers, ovarian cancers, colorectal cancers and so forth. So any place we have these epithelial cells, this can actually cause this type of cancer. So, if a cell expresses too many receptors, that access receptors may stimulate growth at inappropriate times.