And actually, as we'll see in the next lecture what cytokines also do is they actually bridge the innate immune system with adaptive immune system it basically promotes the interaction between the two different divisions of our immune system. While the histamine, what that does is it actually dilates our blood vessels and it also makes the capillaries more permeable to water. Now, along with the mass cells we have these basicil cells which are granulocytes and which travel within our blood. And what the basic fields also do is they also release that histamine. So the histamine causes the dilation of blood vessels leading to that infected area and that is why we have this area of redness along our cut because the redness is caused by the flow of blood into that infected area. Now the capillaries are also affected as a result of that histamine and the capillaries in that infected area essentially become more leaky, become more permeable to that water, to that blood plasma and this ultimately causes the process of swelling which we call edema.