Now, because this substance is assumed to be freely filtered, that means 125 ML/minute is actually filtered. So that means as it passes across the tubular section of the nephron, because none of it is actually reabsorbed and none of it is secreted by these peritubular capillaries back into our tubule, the filtrate that means the renal clearance is simply equal to our globe Maryal filtration rate of 125. So this quantity of blood plasma that enters this tubular section of the capillary is completely cleared of that substance. Now, what's an example of such a substance? Well, one example that is not naturally found in our body, but our doctors use to study the global filtration rate is known as insulin. So inulin or inulin is this polysaccharide that we can basically ingest into our body and which is basically follows this pathway as described.