And when this takes place, the cell essentially stops uptaking the glucose from that blood from that nearby environment. And so when the hexokinase is turned off, the glucose will remain in the blood in that surrounding environment. And in this manner we see that the inhibition of the phosphor fructokinase by the ATP will ultimately inhibit the activity of the hexokinas. And finally, let's move on to the Pyruvate kinase. So pyruvate kinase is the enzyme that catalyzes the last process in glycolysis and this is also virtually irreversible. It only takes place in this direction.