When the enzymes activity, the velocity of the enzyme is exactly half of the maximum velocity and at this point, exactly half of the active sites on the enzyme mixture in the enzyme mixture are actually filled with the substrate. Now, and this must be emphasized, we can only use this second meaning as long as we remember that we made this assumption because this entire work is only meaningful if this is actually used. So if this is true, if K one is much greater than K two. And what that means is if a dissociation of the enzyme complex going this way takes place at a much higher rate than the enzyme substrate complex dissociation going this way, then in that particular case the mechanics constant also describes the likelihood that the substrate will dissociate from the enzyme. If Km is high, that means our dissociation constant is high. And so our equation will shift towards the right side.