Well, by increasing the levels of Arginine, we essentially will replace the arginine. So we will increase the levels of Arginine. And by increasing the concentration of this reactant, we'll increase the rate of reaction five. And so by increasing the rate of this reaction, we produce the only thing that we need in step number two. And so essentially, if we continually replace the Arginine, we give the patient the arginine, we drive this reaction. And so that will allow step two to take place and that will also allow step three to take place, because once we produce the citrulline, by combining this molecule and this molecule, we essentially combine the aspartate with citrulline to combine Arginosuxanate.