And so what that means is once the blood vessel actually is cut, once the endothelium ruptures, the blood clots do not form at a high enough rate, and so excessive bleeding may occur. And this is exactly why hemophilia A is a bleeding disorder. So in individuals with hemophilia A, when they essentially cut a blood vessel, this is basically what takes place. And this is why it actually takes place. And the final thing I'd like to mention is, as you might know from basic biology, hemophilia A is actually a sex linked recessive trait. And that's exactly why male individuals basically are those that have an express the hemophilia a because it's a sex link recessive trait.