And so let's begin with the high blood glucose levels. So let's suppose we just ate a meal that is rich in carbohydrates and so we break down the carbohydrates into the individual glucose molecules and that means the concentration of glucose in the blood essentially rises. And as it rises that signals the release of insulin hormone molecules. And insulin basically goes on and creates some type of signal cascade that essentially ultimately activates a molecule known as phosphoprotein, phosphatase. And this is the same molecule that we basically discussed here. Remember the phosphoprotein, phosphatase is the enzyme that catalyzes the transformation of the Bifunctional enzyme from B state to the A state.