So we see that any deletion or insertion of a nucleotide that is not a multiple of three nucleotides will cause such a mutation, such a shift in the frame. And such a mutation is commonly known as a frame shift mutation. So we see that a frame shift mutation is caused when we have either an insertion or a deletion of a nucleotide or nucleotides that are not a multiple of three. But what exactly happens if the insertion or deletion occurs in a multiple of three? So let's suppose, let's consider what happens when we insert a three nucleotide sequence into this DNA antisense strand. Let's see what the end result will be.