Now, what about the temperature? So when our cells are carrying out many metabolic processes, they don't only produce carbon dioxide as a byproduct, they also produce thermal energy. And this thermal energy is transferred into the blood plasma of our capillaries. And what it does is it increases the temperature of the environment within our capillaries. Now, by increasing the temperature of our solution, we ultimately affect the affinity of hemoglobin to oxygen. Because the hemoglobin is now at a higher temperature, it's moving at a higher kinetic energy.