So once with this process happens, if we examine Ubiquitin, the 48th residue of Ubiquitin is a Lysine. And that Lysine is used in the same way that we use the Lysine of this target protein to basically attach a second Ubiquitin molecule in this same fashion here. So if we study the structure of Ubiquitin, ubiquitin at its 48th position will have a Lysine. And that Lysine will contain this nitrogen atom that will be able to form a bond in the same fashion that we show here. And so we'll form an isoppeptide bond, and we'll attach a second ubiquitous, then a third ubiquitous, a fourth ubiquitous. And at that point, we target that protein for degradation.