And once they bind, they will create a conformational change in the structure of this phosphoralase A of the liver. And it will basically shift the equilibrium toward the T state. In the T state, the enzyme is not active, it has low activity, and so it will not break down glycogen into glucose. And that makes sense because after we ingest the meal rich in sugar molecules. We don't want to produce and release any more glucose molecules into the blood. Now, what about when we have low blood glucose levels?