The second level will discuss in just a moment. So once this takes place, once the Epinephrine binds onto its side, it causes a conformational change that allows this structure to expel that GDP and instead of that, basically bind the GTP and that decreases the affinity of this G alpha protein to this structure and this dimer. And so they dissociate. Now, this structure basically goes on and binds until another transmembrane protein, an enzyme found in the membrane known as adenylate cyclase, which is shown here. So the adenylate cyclist basically contains twelve membrane spanning alpha helices found in that membrane. And then we also have two domains found on the intracellular side.