And this is known as hyperventilation. And it also puts stress on the heart by increasing the rate at which the heart actually pumps. Now, although these are useful immediately, they're not very useful in the long term because this puts a lot of stress on the heart. So these responses, although they're effective immediately, they're not actually very safe and they're not very effective. And so a much more safer and a much more effective and efficient way, a much more long term response is to actually increase the concentration of a molecule we call 23 BPG. And we'll see why that is in just a moment.