So we see that the liver pyruvate kinase is the l isosome, in contrast to the misozyme that we find in muscle cells. So the Lysosome predominates in liver cells, the Lpyruvate kinase responds to the same allosteric effects. So as we discussed a moment ago, ATP alanine and a fructose 116 bisphosphate. But in l isozymes, they also respond to covalent modification via the process of phosphorylation. So when the blood glucose levels are low, the phosphorylation process of this l is I, basically makes that molecule much less active. And this means more important tissue cells.