And once the GTP is bound, it activates the g protein, causes it to actually dissociate from this orange glucagon receptor. And once this g protein dissociates, it moves on onto adenylate cyclist. And what it does is it stimulates adenylit cyclase and enzyme to basically begin the catalyzation the transformation of ATP molecules into cyclic amp molecules. Now, cyclic Amp molecules are secondary messengers whereas the Glucagon hormones are primary messengers in this Glucagon signal transduction pathway. And so what cyclic Amp molecules do is they move on and bind onto the inactive version of PKA. So blue means inactive and red means active.