This situation when we have a higher percentage of two three BPG, a higher concentration of two three BPG inside our blood. So how will increasing the amount of two three BPG affect the oxygen binding curve? Well, it will shift the curve to the right, as seen in the following diagram. And this will decrease the finity of hemoglobin for oxygen. And this means that hemoglobin will be able to unload and deliver more oxygen to the tissues. And that's exactly why at high altitudes, our body wants to increase the concentration of two three BPG over time because we don't want to continually put more stress on the heart and cause it to basically increase the rate at which it pumps.