So to see what we mean, let's take a look at the following diagram. So this cell, this cell and this cell and this cell, they all took up those plasmids, but this cell did not take up the plasmid. Now because these cells have the plasmids and each plasma contains that blue gene, these four cells will all have resistance to antibiotics. But this last cell that did not take up the plasmid, it will not have resistance to drugs. And so if we expose this last cell to antibiotics, it will die off. In fact, that's exactly what we do in the next step in step four.