So individuals with taste act disease typically begin showing symptoms by age one and usually die before age five. So this is a very, very dangerous type of Autosole recessive disease. Now, these individuals, individuals that are homozygous recessive, basically are individuals that lack the gene that codes for a special enzyme that breaks down fats in the brain cells of our body. And because those lipids, those fats, are not broken down properly, they basically build up, they accumulate in the lysosomes of our brain cells. And that accumulation eventually leads to many different types of problems. For example, blindness as well as mental disabilities.