The force involved is electric in nature. Now, when the enzyme binds with our substrate this complex is known as the enzyme substrate complex. So in most cases, for the enzyme to actually function effectively and efficiently another type of molecule, a non protein molecule, has to bind to our enzyme and this molecule is known as a Cofactor. So Cofactors are non protein molecules that basically optimize the activity of our enzyme. And Cofactors can be broken down into two categories. So we have our metal ions, which are basically inorganic cofactors and we have the coenzymes, which are the organic Cofactors.