And to begin, let's actually look at this axon terminal of the presynaptic nerve cell. So along the axon HALOCK of this presynaptic nerve cell, an action potential is generated. And that action potential propagates all the way to the axon terminal of this cell. And once at the axon terminal, it basically stimulates the release of hundreds of these vesicles that carry acetylcholine molecules. So these vesicles containing acetylcholine are released into this area known as the synaptic cleft, and it travels along that synaptic cleft, and these acetylcholine ultimately end up binding onto special ligand gated I channels we call acetylcholine receptors, which are these protein membranes shown here. Now, when they bind, they cause the opening of these ligand gated ion channels.