Well they release histamines and histamines when they move into our blood they dilate the blood vessel and that increases the flow of blood to this infected area. And that in turn as we'll see in just a moment brings more of the white blood cells that basically help protect this area. Now the other chemical that they release is heparin and heparin is basically an anticoagulant. And what that means is it decreases the blood clotting capability of our blood and that makes the blood more leaky and also increases the flow of blood to this area. On top of that these chemicals also make the capillaries more leaky and that means more blood can actually get into the tissue and that means more of these white blood cells can end up in the tissue that is infected by this pathogen. So these chemicals essentially initiate the process of inflammation that takes place in the innate immune system.