So essentially, upon the binding of the glucose molecule or other monosaccharide onto the glucose transporter, a conformational change takes place that allows the movement of that glucose or other monosaccharide into the cytoplasm of that cell. So let's suppose we have a high concentration of glucose in the blood plasma, a low amount in the inside the cell. And so the glucose will move down into concentration gradient from the outside to the inside. So inside our body, to be able to fine tune the regulation of this biochemical process, we basically depend on different types of isozymes of glucose transporters. And in fact, we have over ten different isozymes of glucose transporters. And in this lecture, we're going to focus on the first five, perhaps the most important of these glucose transporter molecules.