Now, previously we saw how the energy charge value within the cell, the ratio of ATP to amp can actually be used to regulate the process of glycolysis and gluconeogenesis. So we can use the energy charge of the cell to basically tell us if glycolysis or glucomaogenesis actually predominates. Now, although that's true for liver cells and for kidney cells, because they regulate and maintain glucose levels, they also can use the glucose levels in the blood to basically determine whether glycolysis or gluconeogenesis actually predominate. So on top of using the energy charge value to help us determine which process predominates, the glucose levels in our blood can also be used to actually tell us which one of these two processes actually predominates glycolysis or gluconeogenesis. Now, the key element in this regulatory pathway, which is once again a reciprocal regulatory pathway and we'll see what that means in just a moment. The key element in this pathway is a bifunctional allosteric enzyme that contains two different types of domains.