Now, why would we want this extra mode of regulation in our liver cells? Because again, the liver cells under, let's say, starvation conditions don't actually need that glucose as much as, for example, brain cells do. And so what that means is if we have very low amounts of glucose in the blood, our pyruvate kinases will be disabled via this phosphorylation, and that will make sure that the glucose molecules are not uptaken by the liver cells and they actually reach the brain cells and the muscle cells, the cells that actually need them more than the liver cells. So we see that the liver pyruvate kinase is the l isosome, in contrast to the misozyme that we find in muscle cells. So the Lysosome predominates in liver cells, the Lpyruvate kinase responds to the same allosteric effects. So as we discussed a moment ago, ATP alanine and a fructose 116 bisphosphate.