So they form this bond at the same time, some type of nearby residue acts as a base and usually the residue is glutamate. So this acts as a base and basically grabs off the h. It pulls the h away from this oxygen and that transforms the oxygen into a much better nuclear file. So it creates that hydroxide. And now this can act as a nucleophile attacking the carbon of the carbonyl and once again forming a tetrahedral intermediate. And then following several steps, we basically collapse and break apart that tetrahedral intermediate and eventually we hydrolyze that peptide. Bond now, one example of a metalloprotease that is found inside our body is carboxy peptidase a.