Now, what happens when the insulin actually binds? So insulin is the primary messenger of this particular pathway and the insulin shown in orange binds into this cavity that is created by these two alpha units. And once the insulin actually moves in these two structures the alpha units actually close in. And as they close in, they seal off this region so that the insulin cannot actually detach. On top of that, they also cause these two beta subunits to basically move closer together. Now, as these two beta subunits move closer together the activation region of one of the beta subunits actually moves into the active side of the other beta Subun.