So in the unphosphorylated state, the PFK two domain, this one is active while this one is inactive. And we said that when this one is active its function is to phosphorylate some type of molecule. Now what molecule will basically an intermediate in the process of glycolysis and also an intermediate in the process of gluconeogenesis. So fructose six phosphates and this phosphorylates fructose six phosphate into fructose two six bisphosphate. And we actually spoke about fructose 26 bisphosphate in the previous lecture. So we saw that fructose 26 bisphosphate is actually an allosteric effector molecule that affects the activity of enzymes in glycolysis as well as gluconeogenesis.