And notice the arrow is much longer going this way than this way. And what that means is the binding is essentially irreversible. The equilibrium lies very far to the right side of this chemical reaction. Now the majority of the time when this binding takes place between the Irreversible inhibitor and the enzyme, the binding is via covalent bonds. But sometimes we can also have non Covalent bonds. So some inhibitors will bind to enzymes very tightly, either by covalent or non Covalent means.