As the pilot begins to bind onto the trim or active sides, the entire trimmers begin to move apart. As they move apart, they rotate, and they cause the movement of these regulatory sides. And so the entire molecule basically expands. It becomes more relaxed, so it becomes less constrained. And what that means is the active sites of the other active sites, which are unoccupied will basically increase the affinity for the substrate molecule and they will be much more likely to actually bind onto those Units. And what that means is, because we have more than one active site, those active sites will basically be able to interact with one another as a result of these structural changes that take place upon the binding of that substrate molecule to the active side of the enzyme.