And what that means is glucagon can no longer act as a primary messenger and so this pathway will no longer be initiated. Now, the second method is the G protein. So the G proteins involved in this particular pathway, namely this G protein shown here, actually contains an intrinsic Gtpa's activity. And what that basically means is sometime after this process actually turns on the G protein, the G protein itself has the ability to hydrolyze the GTP back into GDP. And what that does is it turns off the G protein, the G protein returns back to this location here. And once the G protein dissociates from adenylate cyclist, that turns off the catalytic activity of adenylate cyclase and that stops transforming ATP into camp.