So thrombin has a dual purpose. It not only actually forms the blood clots, but it also is responsible for inhibiting the coagulation process by activating protein C, because what protein C does is it breaks down and digests two important stimulating proteins, part of that coagulation cascade, namely factor five and factor eight. Now, factor five, if we remember from the previous several lectures, is basically that stimulating protein that binds onto factor ten and that activates thrombin. On the other hand, we have factor eight, which is also known as the antihemophilic factor. And this is responsible for binding onto factor nine, which activates factor X into its active form. So protein C is responsible for essentially inhibiting the intrinsic pathway, while tissue factor pathway inhibitor is responsible for inhibiting the extrinsic pathway.