And once they express more of these glute four, they're able to actually uptake all those glucose molecules from the blood plasma following the ingestion of that carbohydrate rich meal. So glute four are found in the cells of muscle and adipose tissue, they have a km value, the maclus constant of about five millimolar and respond to insulin. And following food ingestion, muscle and fat cells express many more glute four membrane proteins to assist with glucose uptake. So we essentially ingest that food, our glucose levels basically rise, and the rise in glucose levels allow the liver cells and our kidney cells and other cells to basically uptake that glucose as a result of the action of this glue too. And the pancreas cells also uptake the glucose, sensing that glucose increase. And so the pancreas releases the insulin, which goes on to stimulate the muscle cells and fat cells to begin basically expressing more of these glute four, to uptake more of those glucose molecules to essentially bring that glucose level in the blood back to normal, back to a value of about five millimolar.