So whenever our cells actually uptake sugar molecules, the first step in the breakdown of glucose in glucose metabolism is to phosphorylate glucose, is to basically transform the glucose into glucose six phosphates. So on the reactant side, we have the beta anomer of the cyclic form of glucose. So we have carbon 12345 and six. And this is the anameric carbon and it's the beta anomer because the hydroxyl group on carbon one points in the same direction as this group attached to carbon number five. So in the process of phosphorylation, when we transform glucose into glucose six phosphate, we essentially add the phosphoryl group onto carbon number six, as shown in this diagram. Now, what's the major difference between the glucose and the glucose six phosphate?