So after the reaction takes place, the energy must be more dispersed and more spread out than before that reaction actually took place. And what that means is, for this to actually be true, the right side of the equation, the delta S of the universe, must always be a positive value, right? So this is the same thing as saying this. Now, this quantity, the right side of the equation, is going to be a positive value only if this quantity here, the delta S of the system, is greater than this quantity here. If this is greater than this, then when we take the difference of these two values, this will be a positive value. So we see that according to the second law of thermodynamics, in any real biological process, the entropy of the universe must always increase as per this equation.