So how exactly is this reaction an ordered sequential reaction? So to see what we mean by that, let's take a look at the following five diagrams. So, in diagram A, we basically have the active side. This crevice is the active side of the lactate dehydrogenase. And what must happen is this coenzyme, the NADH, will bind into the active side of that enzyme first before the pyruvate actually binds. Only then, only when we bind the NADH into the active side, can the pyruvate actually move into the active side and bind into the active side.