Now, when the epinephrine concentration drops in the outside bind lashes layers principle to basically compensate for that drop in concentration of the free epinephrine, that epinephrine that is bound actually dissociates. So if we have a high concentration of epinephrine in that extracellular environment in its free form, it will not be likely to dissociate. And that's why we actually have to depend on this second method. So in the second method we have a special protein kinase we call the beta Adrenergic receptor kinase and it's basically a kinase protein which means it uses ATP to actually add or phosphorylate that particular protein. So the beta Adrenergic receptor kinase uses ATP to actually phosphorylate the carboxyl terminal side of this protein which is found on the intracellular side. And so we essentially add these negatively charged phosphate groups onto this structure and that decreases its affinity to basically go on and activate these alphagy proteins.