So our liver, and to a smaller extent, our kidneys, undergo the urea cycle. And this cycle allows us to transform this toxic molecule, ammonium, into a less toxic form, urea, which is then transported via the bloodstream into our kidneys, where this molecule is eliminated by the kidneys via urine. And this is the only way by which our body can actually eliminate this ammonium, the byproduct of amino acid metabolism from our body. So what do you think would happen if there is some type of defect or deficiency in any one of the enzymes involved in the urea cycle? Well, since this is the only way by which we rid the body of ammonium, that implies a deficiency in any one of these enzymes will decrease the ability of our liver body to actually eliminate ammonium. And that will drive the levels of ammonium inside our body up.