So we see that these two Ketone bodies will increase the levels of H plus ions in the blood, and that will, in turn, increase the H plus ion concentration in the tissue. In addition, what will also happen is as a result of ketonuria, the release of these Ketone bodies in the kidneys, what will happen is osmosis will take place inside the kidneys. And so we're going to release much more water than usual. So on top of increasing the levels of H plus ions in the blood and tissues, we're going to increase the amount of water that we release by the kidneys. So we essentially decrease the volume because we decrease the water concept in the blood, we increase the concentration of H plus ions in the blood. And what that does is it causes severe Ketoacidosis.