So we see that the fact that we have these phosphate groups does two things. It essentially dictates what that three dimensional shape of that DNA molecule, an RNA molecule is in an aqueous environment and it also increases the resistance of our DNA molecule to hydrolysis. So it makes it much less susceptible to hydrolysis. So this process does not generally take place because these two negative charges essentially repel one another as a result of electrostatic repulsion. Now, the final components that we have to discuss, have left to discuss are the bases. So remember, any nucleotide consists of a phosphate group, a sugar molecule and a base.