Now, what happens if that polypeptide that initially begins with the correct primary sequence? What happens if it folds incorrectly? So normally if it folds incorrectly that means the final threedimensional structure of that polypeptide will not be correct. And because it's the three dimensional structure of the polypeptide that determines what the function of that polypeptide is the function of that final misfolded protein will not be the same. And usually these types of misfolded proteins are biologically inactive. And what that means is our cells will either denature and break down these proteins or refold them into the correct structure.