Number one is it makes the glucose more polar by adding that negative charge and this traps the glucose inside the cell. So the negatively charged phosphate group prevents the glucose from moving across the cell membrane because that membrane transport protein cannot actually attach to the glucose six phosphate because of this altered structure. Now the second reason is to begin destabilizing this molecule that increases its energy, makes it more reactive. So the addition of a charged moiety onto the glucose destabilize the structure of that glucose and increases its energy. And this makes it more reactive and more likely to actually undergo and continue glycolysis. Now let's focus in on the hexokinase.