And actually it involves even more molecules than shown on the board. And what it also has is many different types of positive feedback loops. For instance, what Thrombin actually does is it not only activates fibrinogen into fibrin, as we'll discuss in detail in just a moment, thrombin also creates many different positive feedback loops. So it actually moves on to many of these zymogens and it further activates those zymogens into their active form. And what these different positive feedback loops do is they further amplify the number of Thrombon that we actually form. So that what happens is as soon as we have that rupture, we form many of these blood clots very quickly and very effectively, so that none of that blood plasma actually leaks out into the extracellular environment found outside that blood vessel that we can actually seal off that rupture very quickly and very effectively.