So translocation can also lead to down syndrome. But in an individual that has down syndrome due to translocation, that individual actually contains the normal number of chromosomes 46. But one of those chromosomes is actually abnormal. So not all down syndrome cases are due to trisomy 21, although the majority are due to trisomy 21. About 4% of the individuals with down syndrome actually still have the normal number of chromosomes 46, but one of them is abnormal as a result of the process we call chromosomal translocation. So for example, let's suppose we have the following two normal pairs of chromosome.