So eventually that will kill off many nerve cells in our brain. In fact, if we examine the brain of an individual that has Kryitzfeld Yakub disease we'll see that the brain will resemble a sponge in the sense that it will contain many holes because those holes are a result of the fact that many nerve cells have died because these aggregates have killed off those cells. So in the case of CJD. These proteins end up killing off many of the nerve cells, which eventually degenerates the mental capability and the brain function of that particular individual. And patients with these conditions develop a sponge like brain that basically resembles a sponge in the sense that it contains many holes. And those holes come from the fact that these aggregate molecules kill off the different types of cells, different types of nerve cells inside our brain.