So, when these cells are carrying out more metabolic processes at a greater rate, we produce thermal energy. And that thermal energy essentially stimulates the hemoglobin to become much less likely to bind to oxygen so that they can unload that oxygen at a greater rate so that the cells can receive the oxygen they need to continue carrying out the metabolic processes. Now, the next question is how will this affect the oxygen hemoglobin dissociation curve? Well, let's take a look at the following diagram. The Y axis is the percent saturation of hemoglobin and it ranges from zero to one ZeroZero. Now, the X axis is the partial pressure of oxygen within our tissue given in millimeters of mercury.