Well, let's suppose we have a diabetic individual and a diabetic individual forgets to take their insulin. What happens? Well, basically, after a meal, we're going to have high levels of glucose inside our blood, a condition known as hyperglycemia. Now, if we don't have any insulin, then that means the liver cannot actually absorb that glucose, because remember, the insulin is used to upregulate the absorption of glucose into the liver. If we have no insulin, we cannot absorb the glucose. So if we can't absorb the glucose into the liver cells, the pedicides, what that means is we're going to decrease the level of oxalo acetate inside our liver cells.