So our tigunctions blocks the lateral movement of integral proteins from the apical side of the cell membrane. To the basil lateral side of that cell membrane. This means, or this makes sure that the proper endocytotic and exoptototic processes actually take place on the correct side. So on this side we usually have of the endocytotic process, on this end we usually have the exocytotic process. For example, if water actually wants to get in on the lumen side, it has to pass via our passive diffusion and then leave this side via, once again, passive diffusion. But if some other large molecule wants to get in, for example, a sugar molecule, it has to actually get in through our integral protein on this side and then get out through another integral protein on the bottom side.