And so what that means is the protein Glycosylation process does not take place correctly. And because we have the unmodified mannose, because we don't have the mano six phosphate, those hydrolytic enzymes do not actually know that they should go into the lysosome. And so what happens in individual with the eye cell diseases? These hydrolytic enzyme, hydrolytic enzymes basically end up being transported out of the cell. And so in individuals with the eye cell disease will have a high concentration of these hydrolytic enzymes in our blood plasma, and the lysosomes are going to be deficient in these hydrolytic enzymes. And what happens if we don't have the hydrolytic enzymes inside the lysosomes?