So initially we begin to break down these bonds, these non covalent interactions, so that eventually we go from the native state to intermediate state A, where all of these bonds are essentially broken down. Now, in the process, by breaking down these bonds here, we change the shape of our molecule and we cause other bonds to begin to break as well. So other segments of that protein molecule begin to break down as well. So for example, these bonds here are affected and so they break down as well. And so these bonds begin to break down. So in this particular case, we begin to break down our tertiary state.