But as those substrate molecules and in this particular case, as the bi substrate analog, the polyp molecule begins to bind onto the active sites of the enzyme. What begins to happen is the primers basically begin to move away from one another. And as more and more active sites are filled, the trimmers move even farther. And as they move, they rotate and they cause the dimers to also rotate and move. And that creates a quarterly change in the quarterinary structure of that molecule. And that causes it to basically go from the T state to the relaxed state.