So if we look in the following diagram, we have this active side. And what the active side does is when it actually binds onto that substrate, it essentially closes off ever so slightly and it creates this microenvironment that is predominantly nonpolar. In fact, the only time we're going to find water molecules inside the active side is when the water molecule is actually a participant or reactant in that particular chemical reaction. Otherwise, we'll never find the water molecules inside the active side. And that means the environment in the active side is non polar. Now, what this microenvironment does is it brings the reactants very close together and it orients them in just the right orientation for that specific reaction to actually take place.