And again, I have to emphasize that the coenzyme we call acetyl COA is required for the CO2 to bind to that binding. And without it, that binding will not take place. And actually, as we'll discuss in more detail in a future lecture, this actually creates a very important, a very important regulatory point of the process of glucosegenesis. So remember this point because we're going to cover it again in a future lecture when we discuss how we actually regulate the process of gluconeogenesis. Now, by the way, this entire process, step one, takes place entirely in the matrix of the mitochondria of our cell. And that's because Pyruvate carboxylase is only found in the matrix of the mitochondria.