So the Pyruvate is transformed into acetyl coenzyme A via pyruvate carboxylation. The citrate then is produced. And once the citrate is produced, it is isomerized into isocitrate. The isocitrate is then transformed into alpha key to gluterate by the activity of isocytrade dehydrogenase. Now, if we want to produce more ATP molecules, we want to increase the rate of the citric acid cycle. So ATP produces a positive feedback loop that essentially increases the activity of this isoctrade dehydrogenase enzyme.