Well, in some cases, we see that when that substrate actually binds onto the active side of the enzyme once the binding takes place, it creates conformational changes. And sometimes in some enzymes that conformational change actually creates a brand new pocket, a brand new region of space that can now bind some type of inhibitor molecule. And that inhibitor molecule can now bind into the space to form the enzyme substrate inhibitor complex. And once this complex is formed, that will essentially inhibit or block the activity of that enzyme. And this type of inhibition is known as uncompetitive inhibition. So in some cases, the binding and the substance to the active side changes the confirmation of the enzyme and creates a brand new pocket we call an allosteric side that was not previously there.