So it's the mano six phosphate that acts as the marker that basically is used to direct the hydrolytic enzymes to the lysosomes. And so normally, if this process takes place correctly and the hydrolytic enzymes are actually properly phosphorylated via this process, only then will they actually end up in the lysosomes. And only then will the lysosomes actually be able to carry out their process. Now, what happens in individuals that have the eye cell disease? Well, in individuals with the eye cell disease, this phosphate transferase cannot actually create the mano six phosphate. So what happens is, when the hydrolytic enzymes end up inside the Golgi apparatus, that mano sugar remains unmodified.