Now, we see that in non competitive inhibition, sometimes the enzymes will have that active side as well as that additional pocket, that additional allosteric space, regardless of whether or not that enzyme is actually bound onto that substrate inside the active side. So some enzymes have a permanent allosteric site that can buy inhibitors. And these inhibitors are known as non competitive inhibitors because they do not buy into the active side. And so they do not actually compete for the active site with that substrate. And so these non competitive inhibitors can bind to the enzyme regardless of whether or not the substrate is actually bound into the active site region. And this is shown in the following diagram.