So before the binding actually took place, we see that we have two domains and these two domains are found relatively far apart. But when that glucose moves into this pocket, the active side of the hexokinase, these two lobes, these two domains basically rotate about twelve degrees inward. And as they rotate, they essentially create this induced fit for the glucose. And that means the glucose will fit snugly inside this region. So as it essentially closes in, it basically squeezes all the water molecules out of this region. And so once we form this structure, we have this induced fit, this perfect fit, and all the water molecules have been removed from the active side.