Well, let's take a look at the following diagram. So, we basically have 625 milliliters of blood volume enters this glomerulus every single minute. And every single minute 125 ML/minute is actually cleared. Now, because this substance is assumed to be freely filtered, that means 125 ML/minute is actually filtered. So that means as it passes across the tubular section of the nephron, because none of it is actually reabsorbed and none of it is secreted by these peritubular capillaries back into our tubule, the filtrate that means the renal clearance is simply equal to our globe Maryal filtration rate of 125. So this quantity of blood plasma that enters this tubular section of the capillary is completely cleared of that substance.