And finally, we have termination. So all these pathways, even though they're very important in actually carrying out some type of physiological effect, they must be regulated and controlled correctly. Because if they are not regulated and controlled correctly, if they're not shut down at the proper times, they can cause damage to our body. And as we'll see in the next lecture, they can actually lead to cancer. Now, what are some common ways by which these pathways are actually shut down? Well, one way is for the primary messenger to actually dissociate from the side of that particular receptor.