Waste byproducts these carbon dioxide, because they are not soluble in our blood plasma, are ultimately moved into the red blood cells where we use carbonic anhydrates to transform the carbon dioxide into H plus ions and bicarbonate ions, which are soluble in our blood plasma. Now, recall from basic chemistry that what determines the PH of anything of our blood plasma, in this case, is the concentration of H plus ions of hydrogen ions inside our blood plasma. So the more carbon dioxide molecules we have inside the blood plasma, the more of these H plus ions we will have inside our blood plasma. So when the tissue is exercising, it produces more CO2 molecules, which ultimately ends up with produces more H plus ions. And because we have a higher concentration of H plus ions, that will make our blood plasma more acidic, thereby lowering the PH of the blood plasma. And this effect is known as the Bore Effect.