After a few seconds to a few minutes, once the signal pathway basically carries out its physiological response, what happens is, because of this internal GTase activity, it takes a water molecule from that cytoplasm. And we have plenty of water molecules in a cytoplasm. So it's never a problem. The water molecule is taken and basically is used to hydrolyze the GTP into GDP. And so we release a single phosphate molecule. And so once this is formed, the affinity of the G protein decreases for that adenocyclase, it basically dissociates and goes on and finds that dimer to form this trimmer protein.