And to see what we mean by that, let's take a look at the structure of our NMP kinase, namely the adenolid kinase. And so this is the domain that we basically spoke of earlier and this is our P loop. So what happens is once the magnesium binds onto the ATP molecule, that creates a correct conformation and then the ATP magnesium complex can move into the active side of this molecule and bind with that P loop structure. And once it binds with the P loop structure, that creates a localized change in conformation. And that localized chain creates a more extensive change in the entire structure of that particular enzyme. And in particular if we examine the purple region, this is known as the lid domain of the kinase.