So we pour the proteins into our funnel, and it travels into this column section that contains our beats. What exactly will happen? Well, let's suppose we have three proteins of varying sizes. So we have a small green protein, we have an intermediate size red protein, and we have a large protein. Now, those tiny proteins, because of their small size, they will be able to fit into the internal structure of these beads. And so what that means is these tiny green proteins will be able to fit into the crevices, the pores inside our bead, and they will spend more time traveling inside our bead, these red intermediate proteins, because of their slightly larger size, sometimes they will be able to fit into the pores, but sometimes they will not.