And so these phosphatases can influence and shut down this protein, these proteins, these proteins and also these two structures here which are actually part of that EGF receptor. And finally we can terminate the pathway by inactivating that receptor of the pathway. And actually we already spoke about one way by which we can inactivate is by removing these phosphoryl groups. Another way is if these two ligands actually dissociate. When the two ligands dissociate, the entire diameter basically breaks apart into monomers and in that particular case it is not as active as in this particular case. And so what that means is that will decrease the activity of this signal transduction pathway.