So one very common misconception about Irreversible inhibition is that these inhibitors always bind Covalently by forming covalent bonds between the enzyme and the inhibitor. And that is simply not true. There are examples of molecules that inhibit Irreversibly, and yet they only form non covalent bonds. So remember that the underlining, the defining point about Irreversible inhibitors is that they bind very strongly and so they will not let go of that enzyme very easily. That is what defines Irreversible inhibition. And once they bind, they change the confirmation.