For instance, gap junctions that will typically find, let's say, between cardiac cells are examples of integral proteins. And these gap junctions do not actually dissociate from the cell membrane. Under normal conditions, we actually have to mix these integral proteins with some type of nonpolar solution, for example, a detergent to actually remove those integral proteins. But the peripheral proteins can easily be removed by, for example, changing the PH or adding some type of salt solution, because what that does is it disrupts those ionic or hydrogen bonds that exist between the peripheral proteins and that cell membrane, as we'll see in just a moment. So we see that integral proteins bond to the membrane extensively via extensive hydrophobic regions. And we even have integral proteins that span the entire width of that bilayer membrane.