So this diagram basically shows one form of Irreversible inhibition. So basically, we have this purple inhibitor binds to some location on the enzyme that blocks this substrate from binding onto the active side. And on top of that, this inhibitor, it will be very difficult to actually take that inhibitor off from our enzyme. And this is the major difference between reversible and irreversible. So Reversible basically means once we bind our enzyme or once we bind our inhibitor to the enzyme, we can easily dissociate it. And the bonding is always non covalent, but in this case, it can be covalent or non covalent, and once we bonded, we cannot dissociate it very easily.