Now, what happens in individuals that have the eye cell disease? Well, in individuals with the eye cell disease, this phosphate transferase cannot actually create the mano six phosphate. So what happens is, when the hydrolytic enzymes end up inside the Golgi apparatus, that mano sugar remains unmodified. And so what that means is the protein Glycosylation process does not take place correctly. And because we have the unmodified mannose, because we don't have the mano six phosphate, those hydrolytic enzymes do not actually know that they should go into the lysosome. And so what happens in individual with the eye cell diseases?