It will be very tense and very constrained. And so that means the affinity of all the active sites for the substrate will be low. And so it will display a low catalytic activity. But as those substrate molecules and in this particular case, as the bi substrate analog, the polyp molecule begins to bind onto the active sites of the enzyme. What begins to happen is the primers basically begin to move away from one another. And as more and more active sites are filled, the trimmers move even farther.