So mast cells are these immune cells, part of our adaptive immune system which basically release an important glycos aminoglycan known as heparin. And heparin is this negatively charged glycos aminoglycan that basically enhances the activity of antithrombin three. It stimulates antithrombin three to basically form these irreversible inhibited complexes with not only thrombin but all these other factors. So factor twelve, factor eleven, factor ten and factor nine. So heparin acts as an anticoagulant by stimulating the binding of antithronbin three to thrombin and the other serum proteases, these ones that we mentioned just a moment ago. Now what do we mean by anticoagulant?