And what that means is instead of transferring the phosphoryl group onto the NMP, that phosphoryl group will be transferred onto the water molecule. And so what the enzyme does is it utilizes catalysis by proximity. It closes off the active side and keeps away the water molecules and so no competing reactions can actually take place. So once again, as the ATP magnesium substrate binds to the P loop, as this complex binds into this P loop here, it induces a local conformational change in the section and that causes a more extensive change. And so the lid domain essentially closes off and then the binding of that second substrate, the NMP molecule into the active side creates additional changes and this causes catalysis by proximity. So these changes in confirmation hold the two substrates close together so in close proximity and gives them the proper orientation that basically promotes the transfer of the phosphoral group.