Well, they basically attach themselves to intermediate filaments found in the cytoplasm of the cell that are composed of a protein known as carotene. Now, they hold so Desmondomes hold two or more adjacent cells tightly together at a localized region. So on this diagram, for example, this is one Desmond, and this is the other Desmond. Notice these protrusions are our carotene intermediate filaments that are found in our cytoplasm of the cell, that are part of the cytoskeleton of that cell, and they connect directly to these localized regions known as desmosomes. Now, desmosomes themselves do not actually prevent the movement of molecules and ions such as water, but desmosomes are usually found in combination with Thai junctions. So if we have a tie junction and a desmosome found on the same side, that means the desmosome will basically hold the cell together, while the tide junctions will not allow the movement of molecules and ions across our cells.