This protein is hemoglobin. So normally, hemoglobin binds oxygen in the lungs and it unloads that oxygen in the tissues of our body and then it returns back into our lungs to pick up more oxygen. Now, in individuals with sickle cell anemia, what happens is the amino acid number six on the beta subunit chain. Remember, hemoglobin consists of two alpha units and two beta units. So in individuals with sickle cell anemia, the glutamic acid amino acid at position number six on the beta subunit hemoglobin is replaced by valium. And what that does is it changes the hydrophobic properties of hemoglobin.