And we'll see that in this step, as we'll see in just a moment, this actually creates that entire sealing process, whereas seal off that active side completely. So we go from the open confirmation to the closed confirmation. And what this also does is upon the binding of the oxalo acetate to the active side of the citrate sentase, it creates an additional binding site in that active side that can now bind the CETO coenzyme A. So we see that once the oxyloacetate binds to the active side, it creates conformational changes that induces the opening of a binding site, the creation of a binding site that can bind the CETO coenzyme A. And what it also does is it basically shifts the catalytic residues in the actuide in their proper orientation, which can basically begin this aldol condensation step. So once again, the enzyme first binds the oxalo acetate into the active side, which causes the conformational changes in the structure.