And so what that means is the active sites in these catalytic triumphs are going to have a low affinity for that substrate molecules. And so at low substrate concentrations, the substrate molecules are not going to be likely to be bound to those active sites. And so that will create a low catalytic rate, a low catalytic activity. Now, when we begin to increase the substrate concentration inside the cells of our body, the substrate molecules will begin to bind onto the active side. So let's suppose one substrate molecule binds onto one of the active sides of this enzyme. And once the binding takes place, what that does is it shifts the equilibrium of this entire equation slightly to the right side, from the T state to that r state.