So the question is how do intermolecular bonds, how does the reaction solvent and how does thermodynamics basically influence this reaction, the formation of the double helix of DNA. So let's begin with the intermolecular interaction. So the question is how exactly do these intermolecular interactions drive the formation of the double helix? So let's take a look at the following diagram that basically describes a portion of our double helix. So this is the deoxyribo sugar, and for simplification purposes, I've omitted the hydroxyl group. So no hydroxyl groups are found on these sugar molecules.