And once again, increasing the concentration of two, three BPG will cause a rise work shift on our oxygen hemoglobin dissociation curve. So we see that increasing four of these different things will shift the curve to the right, and that will make it more likely for a hemoglobin to unload that oxygen and deliver more oxygen to the cells of our tissues. So we have increase in H plus ion concentration, increase in temperature, increase in the concentration of CO2, and increase in two, three BPG. That all creates a ripe work shift in the hemoglobin dissociation curve. Now, the final factor I'd like to discuss is carbon monoxide. Now, carbon monoxide is actually produced naturally inside our body, but it is produced in very, very small amounts.