Now these very tiny blue regions, these structures are basically the pancreatic lipase, the proteolytic enzymes that break down our fats, the lipids into our fatty acids and glycerol. Now, lipase are water soluble and that means they cannot actually mix with the fat globules. Now the problem here is because of the very large size of the fat globules our livease molecules cannot actually access the inside portion of the fat globules because they cannot dissolve into these fat globules. And that means they cannot actually cleave the majority of the ester bonds that basically hold the triglycerides, the lipids together. In other words, the pancreatic lipase can only cleave the bonds the lipids found on the surface of the fat globules and they have no way of actually getting inside those fat globules. Now this makes the efficiency and the rate at which lipase actually cleans the bonds very, very low.