Because of this resonance stabilization, the electrons fluctuate around the carbon and nitrogen as a result of the double bond character and that essentially electrostatically repels the electrons of that water molecule. And therefore in order for this reaction to actually take place at a high enough rate inside our body and in order for us to be able to quickly and effectively break down these peptide bonds we have to use these enzymes, these proteases. Proteases. As we'll see in the next several electros actually make water a much better nucleophile and they make the carbon a much better electrophile. They make these reactants much more reactive and that facilitates this hydrolysis reaction. Now we can actually categorize proteases into different categories.