So K minus one divided by K is equal to the product of these two concentrations divided by the enzyme substrate concentration. And this, from general chemistry, we define to be the equilibrium constant of the dissociation of the enzyme substrate complex. And because Km is equal to K minus one divided by K, which is the same thing as here, the equilibrium constant is equal to Km. So we conclude that the second meaning of the Michelis constant, as long as we make the assumption that K minus one is much greater than K two, so this reaction is much quicker than this reaction. We basically see that the Michaelis constant describes the likelihood of the dissociation of the substrate from the active side of that enzyme. So we see that if the Km value is very large, then that means our numerator term in the ratio is much greater than our denominated term.