Now, why would our beta cells actually be destroyed? Well, one reason is because of an autoimmune disease. So basically, in some individuals, and this is genetic in some individuals, our own immune cells, immune system cells, actually destroy our beta cells. And this can lead to type one diabetes. Now let's move on to the more common diabetes, the type two diabetes. So in people with type two diabetes, their insulin receptors on the target cell membrane have lost their ability to actually bind correctly and associate correctly with the insulin.