So in that particular reaction, that the enzyme catalyzes, once that substrate is inside the active side, when the reaction takes place inside the active, active side, what the active side does is it stabilizes the transition state and decreases the energy of that transition state. And that's exactly what lowers the activation energy that gives energy of activation. So enzymes catalyze reactions by stabilizing the transition state within that particular reaction. And remember, transition states are these structures that are so high in energy that they exist only for a very short period of time. So in that energy diagram, the transition state is the topmost portion of that energy diagram. Now, previously we discussed different types of enzyme inhibitors and we said that a very good enzyme inhibitor is an inhibitor that resembles the structure of that substrate.