And what that means is if we continually increase the concentration of S, the substrate, it will eventually approach and reach very closely the maximum velocity of that enzyme mixture. And so what we see happen is when the concentration of the substrate is very high, that is when the value of S, the concentration of substrate is much greater than the Km value for that enzyme mixture, we see that our blue curve will essentially reach that maximum velocity. Now remember, Km is basically the concentration of the substrate at which the enzyme operates at exactly half of the maximum velocity. So if Km is this x value, the concentration of the s, then if we check out the Y coordinate, that will be exactly midway between the zero velocity value and the VMAX value as shown in the following diagram on the following curve. So we see that when Km is much, much smaller than the concentration of the substrate in that environment, we see that our enzyme mixture is operating at a maximum velocity. And this is equivalent to saying that all the active sites in the enzyme mixture are filled and so the enzyme's velocity is at a maximum.