So, since enzymes active sites essentially stabilize the structure of the transition state, then that must imply that a much more effective and a much better inhibitor of an enzyme would be an inhibitor that resembles not the structure of the substrate, but rather the structure of that transition state. And these types of inhibitors are known as transition state analogues or transition state inhibitors. So we see that these transition state analogs are molecules that resemble the structure of the transition state. And because enzymes ultimately stabilize the energy and the structure of the transition state, these are very, very potent, very effective inhibitors. So let's take a look at two examples. So let's begin by examining an enzyme found in bacterial cells known as proline raysimase.