And when the blood clot in cascade is initiated we produce these blood clots and the blood clots are used to create temporary seals along that area where the cut actually exists on that blood vessel. So we know that blood clots can be very, very beneficial. But on the other hand, if we form too many blood clots or if we can't break down the blood clots properly or if those blood clots escape that localized area where that injury took place that can lead to many, many problems. Now, one problem is thrombosis. So thrombosis is basically the process by which we form the blood clots. And if these blood clots are formed excessively they can basically escape into the cardiovascular system and eventually they can aggregate at the wrong place and that can block the flow of blood.