And that decreases the affinity of the hemoglobin for oxygen. And that shifts the entire curve towards the right side. So from this black curve to this blue curve. And so we see that inside our red blood cells, we have this allosteric effector, the two three BPG molecule that binds onto a location other than the heme group. So it binds towards the center. And the entire purpose of it is to basically stabilize the t state, make the t state more stable and lower in energy, and that drives the curve towards the right side, decreasing the affinity of hemoglobin for oxygen.