And so eventually they will essentially die. And what that means is these Vibrio cholerate are in fact acid labile. And finally, as we'll see in just a moment, these bacterial cells actually affect the activity of G protein coupled signal transduction pathways as we'll see in this diagram, in just a moment. So before we look at the details of this mechanism of infection, look to actually discuss how these bacterial cells can make their way into the, into our body. So let's suppose we're in some third world country where they basically don't have some type of filtration system that basically filters the drinking water. And so you end up drinking contaminated water or eating contaminated food that contains this bacterial cell.