And so by increasing the rate of this reaction, we produce the only thing that we need in step number two. And so essentially, if we continually replace the Arginine, we give the patient the arginine, we drive this reaction. And so that will allow step two to take place and that will also allow step three to take place, because once we produce the citrulline, by combining this molecule and this molecule, we essentially combine the aspartate with citrulline to combine Arginosuxanate. Now, once we form this, by replacing this, the reaction still can't go this way, but luckily, our body has a way to actually eliminate Arginosuxanate. And so ultimately our body will get rid of that extra ammonium by combining the ammonium into this molecule and then continually forming citrulline. And then the second amino group will come from aspartate.