So let's focus on number one. So we said our cells can terminate by using these Gtpas activity G proteins. So this Rasp protein has a certain gene in the DNA that expresses it. Now let's suppose the gene is a normal gene and that means this will be a normal protein. But what happens if that gene that encodes for this structure is actually mutated in some way? And let's suppose we mutate that gene in such a way so that this molecule loses its ability to basically hydrolyze the GTP back into GDP.