And that can lead to brain swelling and brain damage. And that's why hyperamnemia is dangerous in infants who are born with defects in any one of these enzymes. So to explore more of this concept, let's take a look at some of these defects, some of these inborn deficiencies. And let's begin with Argininosuxenase deficiency. So Arginosuxinase is the enzyme that essentially catalyzes step four, the conversion of Arginosuxanate to Arginine and also forming the fumarate. Now, normally what this does is this reaction continually replenishes the Arginine, which essentially keeps reaction five, which keeps reaction five going.