Now, let's move on to uncompetitive inhibition. In this type of inhibition, the only time the inhibitor can bind onto that enzyme is when the substrate is bound to that enzyme. So we have the substrate collides and binds into the active site of the enzyme. And once we form the enzyme substrate complex, that creates a conformational change that creates this brand new pocket, the allosteric site that the inhibitor can now bind to. Now, in the absence of the inhibitor, the enzyme substrate complex will simply form the product, and then the product will dissociate. But in the presence of the inhibitor, that inhibitor will bind onto that brand new allosteric site found on the enzyme substrate complex, and that will form the enzyme substrate inhibitor complex.