And as a result, they will emerge first at the bottom of that column. Now, one analogy that I can give is, let's suppose we have a patch of grass and we have a race between an ant and a beetle. So an ant is a very tiny insect, and because of its very small size, it will have to take all the different pathways inside that grass. So it cannot take any shortcuts because of its very small size, but because of the size of the beetle, because the beetle simply cannot fit through the different tiny pathways where the end can fit, that beetle will make its way further to the end of that grass, the patch of grass, because of its larger size. And in the same analogous way, these larger proteins, because they can't fit in the tiny pores, they can take all those different pathways that our small protein can. These large proteins will make their way to the end, to the bottom of that column first.