In fact, when we'll discuss the signal transduction pathways and we'll look at G proteins, we'll see that G proteins are examples of these peripheral proteins, they can actually dissociate from that membrane and then go on and carry out some important type of process inside our body. So once again, integral proteins come in two types. We have transmembrane proteins that span the entire membrane, and we also have these integral proteins that only partially interact with that particular hydrophobic region. That means they don't actually span the entire membrane, as shown here. In either case, these integral proteins are attached permanently via these strong hydrophobic nonpolar interactions. And so what that means is, by changing the PH or adding some type of salt, for instance, sodium chloride, these integral proteins cannot actually dissociate from the membrane.