So a Nissan Mutation may or may not lead to problems. And an example where it does lead to problems is in sickle cell anemia. So sickle cell anemia is an example of a miscensed mutation that alters the structure of our hemoglobin. It basically changes our amino acid glutamic acid into a valium. And by changing our amino acid, that changes the three dimensional shape of the hemoglobin molecule. And it basically causes the hemoglobin molecules to aggregate with one another, and that can lead to many problems.