And in this particular case, for adenylate kinase the magnesium must interact with these two oxygen atoms to give it the proper orientation and shape to basically be able to bind into the active side of that and MP kinase. Now, not only will the magnesium interact with two oxygen atoms of the triphosphate of the substrate, but the magnesium will also be stabilized by four different water molecules and that will give a stabilizing octahedral arrangement. So these are the two oxygens that come from the triphosphate group and these are the four oxygens. And so the partially negative oxygen of these water molecules will form bonds, coordinate bonds with this magnesium atom and this will stabilize that structure and create a conformational change that will basically bridge that active side structure and the structure of this particular substrate molecule. So the magnesium will interact with two oxygen atoms on the ATP molecule as well as four water molecules and the interaction will hold that substrate in a well defined conformation, a well defined shape that is suitable for the shape of the active side found in that enzyme. And so ultimately, we see that the metal ion serves as a bridge between the substrate molecule and the enzyme.