So the fact that some of these skeletal muscle cells are found far away from blood vessels. So that problem is actually fixed by this same hisIF one molecule because it stimulates the vascular and the file growth fact, the VEGF, to basically stimulate the growth of those blood vessels so that these blood vessels can actually permeate into these hard to reach places that we find these skeleton muscles in. So again, if we continually exercise, we have some type of anaerobic exercise that stimulates the release of the HIF One molecule, the Hypoxia inducing transcription factor one that basically stimulates the expression of the genes that code for proteins and enzymes involved in the process of glycolysis and also code for glucose transporters. On top of that, it also stimulates the VEGF molecule to basically go on and stimulate the growth of those blood vessels and that ultimately increases our endurance and allows us to basically carry out that process much more effectively and much more efficiently. Now, exercise, as it turns out, is not the only process that uses this particular type of mechanism. Another very important and very dangerous thing that uses this mechanism is cancer.