And so when that conformational change in the g alpha Q protein takes place, that's that essentially constricts this side where the GDP is found, it squeezes it out to the GDP leaves, but at the same time, it creates a pocket or region that has a high affinity for GTP guanosine triphosphate. And so a guanosine triphosphate found in a cytoplasmic side basically swimming around. And when it gets close to the cavity, as a result of that electromagnetic attraction, it will be pulled into this cavity and that will basically induce a change in the structure. And once the GTP binds the affinity of this structure here. So this G alpha Q protein decreases in affinity and does not want to bind to these two domains. And so it detaches from these two structures and also from this seven transmembrane region.