So we see that at the final step of the intrinsic pathway, it's this antihmophilic factor, factor eight, that must stimulate, interact with this factor nine to basically go on and convert the Xymogen factor ten form into its active form. Now, if this molecule is destroyed, if there is some type of mutation or if it's missing altogether, then this will not be stimulated and will not be able to actually activate this factor ten. And so if that doesn't take place, then the entire intrinsic pathway basically slows down its impairment. And what that means is we will not amplify the effects, the formation of the blood clots. We're not going to be able to form as many blood clots as we want. We're not going to be able to form them quickly enough.