So if this is very unstable, then that will shift the equilibrium towards the product side, where the product side is the Rstate. And the Rstate is the structure of that hemoglobin that is very likely to actually bind oxygen. So what that means physiologically, in the absence of the two three BPG molecule as a result of the electrostatic repulsion that takes place inside the center of that hemoglobin that drives the hemoglobin towards the R state. And it's the R state that becomes very likely to bind oxygen. And that's exactly why the pure hemoglobin has a very high affinity for oxygen. And that's exactly why the black curve is to the left with respect to that blue curve.