The question is why? What makes this process so effective and so convenient? Well, there are seven things that have listed several reasons that I've listed on the board. So let's quickly go through each one of these reasons and let's begin with reason number one. So in the process of phosphorylation, what we actually do is we transform a neutral residue to a residue, modified residue that contains a negative charge. And because of the presence of the negative charge, it can basically break the old interactions and form better interactions, more stabilized interactions.