And this leads us directly into property number two. Active sites are responsible for stabilizing the transition state as well as forming and breaking the particular bonds involved in that chemical biological reaction. So inside the active side, we have those residues responsible for actually stabilizing and lowering the energy of the transition state. And this is precisely what speeds up that particular reaction. In addition, we have those catalytic groups that are responsible for stimulating the breaking of bonds and the forming of bonds. Now, property number three active sites create a microenvironment.