Now, one thing I'd like to point out about the active side of the enzyme, wherever that active side is, we have these three negative charges on this polymolecule. And the fact that we have three negative charges basically implies that inside the active side of this enzyme we'll find residues that contain positive charges. So basically, those positive charges in the residue interact with the negative charges of this bi substrate analog molecule, the poly molecule. So the next question is what exactly did scientists see when they mixed the poly with this enzyme? Well, what they saw was where that poly actually bound to was at the interface between any pair of these catalytic chains within that primer. So the poly inhibitor binds onto a region located on the boundaries of each pair of catalytic subunits in any one of those catalytic trimmers.