And what that means is we'll have a higher concentration of elastase inside our lungs. And a higher concentration of active elastase means that's going to destroy the tissue found in the alveoli of the lungs. And by destroying the tissue that changes the elasticity of those alveoli and that will make it much more difficult to breathe, we're going to have to breathe harder to exchange the same volume of air. So we see that smoking brings oxidizing agents into the alveoli of the lungs. These agents can interact with the methionine 358 of alpha one antitrupsin and oxidize it. And this will decrease the ability of the inhibitor to bind into the active site of the last days, because it's this methionine 358 that is responsible for actually interacting with that active side of elastase.