And this destabilizes the T state of that deoxy hemoglobin. Now, what does this actually mean physiologically? Well, if the T state is destabilized, there's only one thing that the deoxy hemoglobin molecule can do. So if this is very unstable, then that will shift the equilibrium towards the product side, where the product side is the Rstate. And the Rstate is the structure of that hemoglobin that is very likely to actually bind oxygen. So what that means physiologically, in the absence of the two three BPG molecule as a result of the electrostatic repulsion that takes place inside the center of that hemoglobin that drives the hemoglobin towards the R state.