While all those amino acids that contain the polar side chains, for example Lysine or Arginine, Aspartate, and so forth, all these charged and polar amino acids will be found on the surface of that protein. So this is what we mean by the hydrophobic effect, essentially dictating the way that the tertiary structure is actually formed. So let's suppose, let's take a look at the following diagram. So, in this diagram, we have our protein. So let's suppose that these red regions here are hydrophobic regions. So let's label these as hydro.