So for example, if we clog this region of the capillary, what that does is it increases the pressure on this side and that can push against the walls of the capillaries and that can lead to very painful swelling. On top of that, if we clogged this section then there will be poor blood flow in this region of our capillary and that can lead to poor circulation of the blood in the cardiovascular system. And this in turn can lead to an increased risk of stroke because stroke, remember, is the process by which we don't get enough blood and don't get enough oxygen to the brain. It also will increase the risk of bacterial and pathogenic infection because remember, the immune system of our body uses the cardiovascular system to transport the different types of antibodies and immune cells throughout our system. And so if our blood flow is poor, what that means is there is a decrease in the ability of that immune system to actually carry out its response. So once again, individuals with sickle cell anemia have abnormal hemoglobin molecules.