And in this particular reaction, we're always going to find that it's the lactate that leaves first, followed by that NAD plus molecule. So in an order sequential reaction, to actually catalyze the transformation of the reactants into the products, we have to form the termary structure, this complex in which the active site contains those two substrates. And we also have to basically bind these two reactants into the active site in a specific order. And once we form the products, those two products must be released also at a specific order. And this is in contrast to random sequential reactions. So now let's focus on random sequential reactions.