And that charged molecule will not want to lose those energetically favorable interactions and enter an environment in which it cannot form those same energetically stabilizing bonds. So a charged or a very polar molecule will not be able to dissolve and travel across the cell membrane because to do so, that means it must lose these hydrogen bonds, interactions between the water molecules, and then into an environment in which it cannot form those same stabilizing bonds. So we see that this also means that charged or very polar molecules did not readily pass across the membrane because such molecules, one, lose the strong interactions with water that exist in that salvation shell, that cage of water molecules. And two, they cannot form those same stabilized interactions with the hydrocarbon tails found inside the core of that bilateral membrane. So we see that ions such as sodium ions, potassium ions or chloride ions have a very low permeability. They cannot pass across that cell membrane as shown in the following diagram.