Now, we also have this molecule known as methotrexate. And methotrexate is a competitive inhibitor to this substrate to this enzyme here. In fact, methotrexate is about 1000 times more likely to actually bind onto the active side of Dihydrofolate reductase than Dihydropholate itself. And so that's exactly why it will be much more likely to bind to the active side than the substrate. But if we increase the concentration of the substrate that will essentially outcompete that inhibitor for the active side and that will bring back the rate of the enzyme back to normal. Now, let's move on to uncompetitive inhibition.