Now in addition, what we don't show is these many different types of positive feedback loops that we also have in this particular cascade. And as I mentioned earlier, for instance we have Throb and that creates many different types of positive loops and so it goes back to many of these zymogens and it basically activates the zymogens even further so that ultimately we amplify the number of blood clots that we form at the end. So in addition Throbbin creates many positive feedback loops that further amplifies the formation of the blood clots. Now as we see we have many examples of zymogen. So we have this is a zymogen, this is a zymogen, these are zymogens and so forth. Now the Zymogen that we actually studied very well is this zymogen here.