So we have the inactive version of adenylit cyclase. To activate it, we basically take that GTP form of the G protein. It goes on and binds, and that stimulates that cyclist to produce those cyclic amp molecules. After a few seconds to a few minutes, once the signal pathway basically carries out its physiological response, what happens is, because of this internal GTase activity, it takes a water molecule from that cytoplasm. And we have plenty of water molecules in a cytoplasm. So it's never a problem.