Now, why is that dangerous? Well, we think that high levels of ammonium inside our brain can essentially change the zamotogradient between the inside and the outside of the cell because high levels of ammonium will essentially increase the levels of Glutamine, because the enzyme Glutamine synthetase found in the brain essentially combines the ammonium with Glutamate to form Glutamine. And high levels of Glutamine basically changes the somatic gradient. And that can lead to brain swelling and brain damage. And that's why hyperamnemia is dangerous in infants who are born with defects in any one of these enzymes. So to explore more of this concept, let's take a look at some of these defects, some of these inborn deficiencies.