On the other hand, if Km is actually small, then that means we have a small concentration of the enzyme and the substrate in its individual form compared to the complex form. And so if the Km is small, equilibrium will lie to the left side. So we have a lot of the enzyme substrate complex and that means the substrate will bind strongly and tightly to the active side of the enzyme. So if Km is small, the enzyme binds tightly to the substrate and the substrate will tend to remain bound to the active side. So we see that we can actually give two different meanings to the Mikalus constant. So physiological meaning number one is the Km describes the concentration of that substrate.