And so as the active sides become filled, we see that the tank state, the T state, transitions into the r state, and the equilibrium basically shifts. So to see what we mean, let's take a look at the following diagram. So we have this equilibrium that exists between the T state and the r state. Now, before we add any polymolecules, when they are not present in the environment, in the absence of the polysubstrate or the actual substrate, the aspartate or the carbo moyl phosphate, the coronary structure exists in the T state. And in this state, the enzyme has a low affinity for the subtract molecules and will display a low catalytic activity. On the other hand, as we begin to add the polymer molecules, they begin to slowly add into the active sides found in those catalytic primers.