It basically becomes less constrained, more relaxed, and the affinity of the active sides for the substrate molecule increases as this actually takes place. So once again, as the substrate binds, in this case, as the poly inhibitor binds onto the active side, it causes the two trimmers to move farther apart and rotate, which in turn causes the regulatory subunits to also move. And therefore, the entire structure seems to expand upon the binding of that substrate molecule to the active side. And so as the active sides become filled, we see that the tank state, the T state, transitions into the r state, and the equilibrium basically shifts. So to see what we mean, let's take a look at the following diagram. So we have this equilibrium that exists between the T state and the r state.