So when a total of two EGF signal molecules, the primary messengers bind onto the extracellular region, they induce the dimerization arm of one monomer to stretch out and reach into the pocket of that second monomer which leads to the formation of that dimer structure. And this is what we basically show here. Upon the binding these reach out to interact and form this dimer structure and these also slightly change in confirmation and they also interact with one another. So let's now focus on what happens here. So the conformational changes here lead to conformational changes here. And so what happens here is this C terminal tail that we mentioned just a moment ago basically moves into the active side of that corresponding of that opposing unit.