So about 10% of the CO2 molecules, once they're inside the red blood cell, will bind direct to the hemoglobin and will travel to the lungs by being bound to that hemoglobin. Now, the remaining percentage, so we have 5% here, 10% here. So the remaining 85% of the carbon dioxide will combine with water and by the enzymatic activity of the special enzyme we call carbonic anhydrates, the carbonic anhydrates will catalyze the conversion of these two molecules into carbonic acid. Now, because carbonic acid is a relatively good acid, it will dissociate into H plus ions and bicarbonate ions. Now, the H plus ions will create part of the Bore effect. And so they will bind on special regions onto hemoglobin, and that will decrease the affinity of hemoglobin for oxygen, allowing hemoglobin to unload even more oxygen molecules to the exercising tissue.