And this usually leads to non functional proteins. Now, let's take a look at the other type of insertion deletion, known as a non frame shift mutations. So, on the other hand, an insertion or deletion of nucleotides that is a multiple of three will simply insert or remove a number of amino acids equaling to the number of new codons that are added or removed. And this is known as a non frame shift mutation because the reading frame is not actually shifted and because the majority of the amino acid in the sequence is actually unchanged. Now, let's move on to the second category known as point mutation. So, a point mutation, also known as a base pair mutation or a base pair substitution, is basically a change of a single nucleotide on that DNA template.