Another way is if these two ligands actually dissociate. When the two ligands dissociate, the entire diameter basically breaks apart into monomers and in that particular case it is not as active as in this particular case. And so what that means is that will decrease the activity of this signal transduction pathway. So this is the normal way by which the pathway actually is terminated. But what happens in the abnormal case? How can an abnormality in each one of these cases, one, two, three, actually lead to the production of tumors and eventually cancer?