But even though they're trapped, they're not close enough to actually carry out that catalysis reaction and transform them into ATP molecules. So once we go from this drug to this structure, the ATP molecule actually leaves and now we have this empty spot. And so in the final step, what happens is once the ATP leaves the ADP and the orthophosphate can actually enter this location and the cycle can basically repeat itself again. So we see that the rotation of the gamma subunit that basically lies within the inner cavity of the hexamer ring basically allows the interconversion of the beta subunits from one state to another state. And notice that at any given moment in time all the beta subunits exist in a particular distinct state. And that applies that any given two subunits, two beta subunits will never exist in the same identical state.