And this is what we know as the cooperative behavior of Alphaic enzymes such as aspartate transcarbomolase. And this mechanism can be described by using the concerted model which we actually use to describe the behavior of hemoglobin molecules. So based on this model, the activity of this aspartate transcarbomolase is all or nothing. It either exists in the T state in which this enzyme is inactive or it exists in the r state in which the enzyme is fully active. And it's the concentration of the substrate inside the cell that ultimately determines where the equilibrium will actually lie. And a high substrate concentration, the enzymes coronary structure will exist in the r state while at low substrate concentrations the enzymes coronary structure will exist in the T state.