So factor eight is a protein that plays a crucial role in the intrinsic pathway of the blood clot and cascade. And there are two important roles, as we discussed just a moment ago. So rule number one is it actually plays an important role in actually completing the intrinsic pathway. So we see that at the final step of the intrinsic pathway, it's this antihmophilic factor, factor eight, that must stimulate, interact with this factor nine to basically go on and convert the Xymogen factor ten form into its active form. Now, if this molecule is destroyed, if there is some type of mutation or if it's missing altogether, then this will not be stimulated and will not be able to actually activate this factor ten. And so if that doesn't take place, then the entire intrinsic pathway basically slows down its impairment.