Now, let's begin by focusing on sequential reaction. So what do we mean by sequential reaction? Well, in a sequential reaction, the defining property of a sequential reaction is basically the presence of a ternary structure. And a ternary structure is a structure in which the active side of the enzyme is filled with the two substrate molecules A and B. So the defining property of sequential reactions is that all the substrates, the two substrates A and B, have to bind to the active site of the enzyme to form the ternary structure that consists of the enzyme and the two substrates before the catalysis process can actually take place. And we can convert those reactants into the products.