Now, the same exact alosteric molecules that we spoke about in our discussion of skeleton muscle cells also are applied to these pyruvic kinases found in liver cells. So essentially, if we have high concentrations of ATP, the ATP creates a negative feedback loop that binds until Pyruvate kinase and diminishes its activity, inhibits its activity in the same way that ATP inhibits the phosphor fructokinase. Now, because Pyruvate also forms, let's say, building blocks such as amino acids. If we have because Pyruvate forms alanine, if we have high amounts of alanine, that will also create a negative feedback loop which will go on and essentially diminish the activity, inhibit the activity of pyruvate kinase. But if we have low levels of glucose, low levels of ATP inside our cells, then the fructose one six bisphosphosphate will go on to create a positive feedback loop and stimulate activity of pyruvate kinase. So this is the same exact mechanism that is used by pyruvate kinases found in skeleton muscle cells.