So ultimately the water molecule acts as a nucleophile, this carbon acts as an electrophile. And what happens is this nucleophilically attacks the carbon and ultimately displaces that amide bond, the peptide bond. And notice that the arrow pointing this way is longer than the arrow pointing in reverse. And what that means is equilibrium will lie towards the product side and that implies that the products are lower in energy and more stable than the reactants. So we see that even though this reaction is thermodynamically favorable, it doesn't take place at a very high rate without the use of the protease enzyme. Now, why doesn't it take place at a very high rate?