This cascade consists of the extrinsic and the intrinsic pathways that work together to amplify the activation of an important seren protease known as Thrombin. And Thrombin is that serum protease that is needed to actually proteolytically activate fibrinogen, which then basically forms these aggregates we call fibrin molecules, which consist of this meshlike network that is used to actually seal off that particular clot. So that particular cut and these are known as blood clots. Now in addition, what we don't show is these many different types of positive feedback loops that we also have in this particular cascade. And as I mentioned earlier, for instance we have Throb and that creates many different types of positive loops and so it goes back to many of these zymogens and it basically activates the zymogens even further so that ultimately we amplify the number of blood clots that we form at the end. So in addition Throbbin creates many positive feedback loops that further amplifies the formation of the blood clots.