And this sulfonated product isn't able to actually interact with the active side of the elastase very well. And so we see what smoking does is as a result of the presence of these oxidizing agents, it changes or mutates the structure of the alpha one antitrypsone. So that isn't able to bind to the active side of elastase very well. And what that means is we'll have a higher concentration of elastase inside our lungs. And a higher concentration of active elastase means that's going to destroy the tissue found in the alveoli of the lungs. And by destroying the tissue that changes the elasticity of those alveoli and that will make it much more difficult to breathe, we're going to have to breathe harder to exchange the same volume of air.