So activated protein kinases can be used to regulate many different enzymes and many different reaction pathways. And this can lead to an amplification effect in which we essentially amplify the amount of final product that we produce. Now, number six is whenever this reaction takes place because essentially what we're doing is we're defosphorylating this ATP molecule and the breakdown of the ATP molecule is a very exergonic reaction. It releases energy. We see that this process is in fact thermodynamically stable and the energy of the product is lower than the energy of the reactants. And in fact, about half of the energy, half of the free energy that is released in the defasphorylation of this ATP molecule is stored inside this protein phosphoryl group complex.