Now, in both of these cases, there is some type of genetic mutation in proteins known as paroxins. And these proteins, called paroxins, are basically responsible for actually forming the paroxysome. So in patients, in individuals with these genetic conditions, the paroxysomes don't actually form correctly or don't form at all. And so what that means is these very long chain fatty acids will not be broken down, and they will increase in concentration in those individuals. In addition, paroxysomes have other functions. For instance, paroxysomes also synthesize those lipid molecules that are found in the myelin sheath around neurons, around the axons of neurons.