And the second important function of factor eight is thrombin creates a positive feedback loop, stimulating factor eight, swimming around in the blood to interact with factor nine, which causes an amplification effect. And this is basically this positive feedback loop that I just discussed just a moment ago. So we basically see that in individuals with classic hemophilia, there is some type of mutation. In fact, the eight, or in some cases, factor eight is missing entirely. And so what that means is the impairment of factor eight greatly impedes this process, the intrinsic pathway. And if the intrinsic pathway does not function properly, we cannot amplify, we cannot create these blood clots quickly enough.