But now this becomes a leucine because the UG codon codes not for a valid but for a leucine. So basically, anytime we have a point mutation that takes place on the coating region and which does change the amino acid that is produced, this type of point mutation is known as a miscense mutation. So a point mutation in which one nucleotide is substituted for another, and this causes a change from one amino acid to another. This type of mutation is known as a miscense mutation. So this is shown in the diagram above. And one very common example of a point mutation known as a Nissan Mutation is sickle cell anemia, in which the hemoglobin that is formed is basically not as active as it should be.