Now, eventually they form even larger aggregates. And eventually these aggregates, because they cannot be broken down by the cells of our body by the same exact methods will basically affect the efficiency and the efficiency and the different types of functions that take place in our cells. And the cells in this case are the brain cells, the nerve cells found inside our brain. So eventually that will kill off many nerve cells in our brain. In fact, if we examine the brain of an individual that has Kryitzfeld Yakub disease we'll see that the brain will resemble a sponge in the sense that it will contain many holes because those holes are a result of the fact that many nerve cells have died because these aggregates have killed off those cells. So in the case of CJD.