Now, what is the importance of proxosomes if we have those mitochondria to basically help us undergo the fatty acid oxidation process, why do we need paroxysomes in the first place? Well, to answer that condition, we can basically study a set of genetic disorders that are known as the Zellwegger spectrum syndromes. Now, the Zellwegger syndrome is the very severe form of the Zellwegger spectrum syndrome, while the Adrenal leukodystrophy is a slightly less severe form. Now, in both of these cases, there is some type of genetic mutation in proteins known as paroxins. And these proteins, called paroxins, are basically responsible for actually forming the paroxysome. So in patients, in individuals with these genetic conditions, the paroxysomes don't actually form correctly or don't form at all.