So we when the PH of our blood changes, the hemoglobin's ability to bind to oxygen also changes. And this ultimately changes the oxygen hemoglobin dissociation curve. And this effect, as we'll see in just a moment, is known as the Bohr effect, which was named after the scientist who essentially described it, Christian Bohr. Now, let's begin by discussing what actually affects the PH of our blood plasma. Well, recall that inside our cells of our tissues, the cells undergo many type of metabolic processes, for example, cellular respiration. And when cells undergo these processes, the major byproduct waste byproduct that is produced is carbon dioxide.