And what that means is CO2 molecules will not generally dissolve in the blood plasma. Why is that? Well, because blood plasma consists predominantly of water molecules, which are polar. And polar water molecules do not mix very well with nonpolar CO2 molecules. So only about 5% of the carbon dioxide, a very small portion, will remain dissolved in the blood plasma. And the remaining 95% of the carbon dioxide will move across the cell membrane of the red blood cell and into the environment found inside the red blood cell into the cytoplasm of the red blood cell.