So to see what we mean, let's take a look at the following diagram. So we have the DNA helicase that binds at the origin of replication. Eventually it moves a certain distance and it ends up at the location known as the fork of replication. The fork of replication is basically the location of our DNA helicase. So we can imagine that DNA helicase moves in the left directions towards the left along the x axis we have the DNA gyrase that basically induces those negative super coils that decreases the stress involved with unwinding. And we have the SSB proteins, the single stranded binding proteins that basically act to make sure that those two single strands do not reassociate with one another.