So we see that hydrogen ions and carbon dioxide together create the Bore effect, which actually shifts that entire oxygen binding curve of fumiglopin towards the right side. And what that means is it decreases the affinity of hemoglobin for oxygen. And what that means is it allows the hemoglobin to actually unload and release more oxygen to the tissues of our body. And to see how much more is actually released, let's take a look at this graph. So, let's begin inside the lungs. So, inside the lungs, we basically have a concentration of oxygen of about 100 mercury.