Now, if we have a high energy charge value inside our cells, so we have plenty of ATP molecules to go around and we don't want to produce any more ATP molecules, we see that ATP, as well as these two molecules produced, will act as allosteric inhibitors. So ATP, as well as succinctoenzyme A and NADH will basically act as allosteric inhibitors, binding them to special regulatory sites of this alpha keyoglutrade dehydrogenous enzyme and that will inhibit its activity. And so when we have plenty of ATP, the rate of the citric acid cycle is basically decreased. By inhibiting the activity of these two enzymes, we have isocytrate dehydrogenase, step three and alpha key to gluterate dehydrogenase. Now, in the case of inhibiting enzyme four of step four, we essentially increase the build up of the alpha ketoglutrate. And when we increase the concentration of alpha ketoglutrate, we can actually use the access alpha ketoglutrate to produce specific types of amino acids, as we'll discuss in the future lecture.