And once it binds with the P loop structure, that creates a localized change in conformation. And that localized chain creates a more extensive change in the entire structure of that particular enzyme. And in particular if we examine the purple region, this is known as the lid domain of the kinase. As it binds onto the pilot, this basically closes down just like a lid closes on top of a can. And so, in the same way, this lid basically closes down and it induces a conformational change that traps that ATP molecule in the proper orientation so that now the other substrate, the NMP, can bind onto the active side. And it binds in such a way so that the terminal phosphoryl group of the ATP is in close proximity and in the proper orientation with respect to this and MP molecule.