And two three biphosphoglycerate is a naturally occurring intermediate in the process of glycolysis. So we produce two, three BPG when our cells use glucose and break down glucose for ATP. So within our cells that are exercising, they have a high rate of metabolism. They produce an excess of two, three BPG molecules. These molecules can pass along the membrane into the matrix, and then eventually, they end up within the blood plasma and move into the red blood cells. Now, once the two, three BPG are inside the red blood cells, they go on to directly interact with hemoglobin.