And in this structure, the active sites have a high affinity for the substrate molecule. And so what that means is the rate of activity of this enzyme when the enzyme's quadinary structure is in the r state will be much higher than compared to that T state. And that's exactly why, at high concentration of substrate, the activity of that enzyme will be high because it exists in that r state. So what's actually taking place is upon the binding of the substrate molecules into the active sides. The active sides found on the different catalytic trimers basically begin to interact with one another and they cooperate with one another. And that's exactly what shifts entire curve from one side of the equation to the other side of the equation.