And what that means is equilibrium will lie towards the product side and that implies that the products are lower in energy and more stable than the reactants. So we see that even though this reaction is thermodynamically favorable, it doesn't take place at a very high rate without the use of the protease enzyme. Now, why doesn't it take place at a very high rate? Well, as it turns out, water by itself is not a strong enough nucleophile to actually attack the carbon and the carbon is not a strong enough electrophile and this has to do with the strength of this amide bond. So as it turns out, this bond here shown as a single bond, is not actually a single bond. This peptide bond contains a double bond.