So once again, if the dipeptide bond, if the dipeptide formation as described in this diagram is energetically unfavorable, why doesn't the reverse reaction take place spontaneously? And naturally in our body. Well it turns out that the activation energy is simply too high, it's simply too great. And at the conditions of our body temperature and neutral physiological PH, this reaction simply does not take place. So we conclude the following three facts about peptide bonds and the biosynthesis of peptide bonds. So peptide bonds form via a dehydrolysis reaction.