The following protein that normally exists in the brain cells of our body, in our neurons, in the brain. So PRP, as shown in the following diagram is a normal protein that is found in the brain. And under certain conditions, for example, if some type of mutation takes place this protein can actually miss fold into this protein known as PrPSc. Now, what's the major difference between this protein here and this protein here? Well, one major difference is the fact that this protein consists predominantly of alpha helixes but in this case it consists predominantly it has a very high content of beta pleated sheets. So when this misfolding process takes place instead of forming all these alpha helixes we form these betappleted sheets.