So once again, 23 BPG is not the only atmosphericic effect that improves the efficiency of hemoglobin. Hydrogen ions and carbon dioxide are also allosteric effectors that increase the amount of oxygen that is released by hemoglobin in the exercising tissues of our body. And this effect is known as the Bore effect. So the Bore effect is basically the ability of hydrogen ions and carbon dioxide to bind onto the hemoglobin molecule, stabilizing its T state and decreasing its affinity for oxygen, thereby shifting the curve to the right side. And to see what we mean by this, let's take a look at the following diagram. So, this diagram describes three different oxygen binding curves for hemoglobin under three different conditions.