And ultimately our body, instead of ridding itself of ammonium via urea, it will rid itself of ammonium by getting rid of the our genosuxinate. Now let's explore anodeficiency and let's focus on step number one and step number two. So let's suppose if we have a problem either in carbon mole phosphate synthetase or ornathine transcarbolus, what would happen now? Well, notice that reaction one and two are before this cycle actually takes place. So if we just follow this circular arrow here, if we have a problem here or here, it's before the cycle takes place. And so by replacing any one of these intermediates citrulline, this molecule Arginine, this molecule that will do nothing in a person with carbon oil phosphate deficiency or, ornithine transcarbol deficiency.