And likewise, only in the open state can the submune actually bind the ADP and orthophosphate reactants. Now, in the loose state it actually has the ADP and the orthophosphate bound to it. But because in the loose state the reactants are not brought close enough, they will not be able to react to form the ATP molecules. But in the ten state the structure is constrained and the ATP and the orthophosphate are brought close enough to actually synthesize that ATP molecules. And I have to emphasize the following important points. In the ten state or in the loose state these two states will not release the ATP molecules or the ADP and orthophosphate molecules they're only released in the open confirmation.