And so what we form is this larger abnormal chromosome. And the way that we call it is because we have a fusion of a segment of 21 onto 14, we call this chromosome 1421. So a segment of DNA on chromosome 21 can basically break off and reattach onto a non homologous chromosome, chromosome 14. And the fuse chromosome, this abnormal chromosome, is called chromosome 1421. So when the individual, when the Zygote basically gains this particular chromosome here, that individual, the Zygote, still has 46 of these chromosomes. But the 14th one, this one, is abnormal because it contains this duplication, this duplicated portion of the gene.