During either process, proteins follow a partly defined pathway that consists of these intermediate states. And so what we see in this particular case, we have two intermediate states, but we could also have five intermediate states, ten intermediate states and so forth. And what these intermediate states basically describe is that is they describe energy states. So what that means is when a protein folds or unfolds, it doesn't actually follow a precisely defined pathway, but it follows a partially defined pathway. And what that means is when the protein, let's say, unfolds, it goes from a very stable native state into a less stable state that has its own energy into a higher energy state. So this is even less stable than this and finally into this final state that is less stable than either one of these states.