And once bound, they will not dissociate very easily from the enzyme. And these inhibitors are known as Irreversible inhibitors. They have a very high affinity for the enzyme. So one very common misconception about Irreversible inhibition is that these inhibitors always bind Covalently by forming covalent bonds between the enzyme and the inhibitor. And that is simply not true. There are examples of molecules that inhibit Irreversibly, and yet they only form non covalent bonds.