If we have because Pyruvate forms alanine, if we have high amounts of alanine, that will also create a negative feedback loop which will go on and essentially diminish the activity, inhibit the activity of pyruvate kinase. But if we have low levels of glucose, low levels of ATP inside our cells, then the fructose one six bisphosphosphate will go on to create a positive feedback loop and stimulate activity of pyruvate kinase. So this is the same exact mechanism that is used by pyruvate kinases found in skeleton muscle cells. But again, we have a very important difference in skeleton muscle cells. We actually have an isozyme of pyruvate kinase known as M isozyme, where M you can think of stands for muscle, while inside our liver cells we have the L isozyme for the pyruvate kinase. So essentially, inside the liver cells, we have both l and misozymes.