So recall in our discussion of the hypothalamus and our anterior pituitary gland, we said that the anterior pituitary gland releases a hormone known as our adrenal corticotropic hormone or ACTH. And ACTH is itself released and stimulated by a hormone released by the hypothalamus known as the corticotropic releasing factor. So the Hypothalamus stimulates the release of corticotropic releasing factor which basically stimulates the interior pituitary gland to release ACTH. And then ACTH enters our bloodstream and travels down into our adrenal cortex, an adrenal gland, and basically stimulates the release of our corticosteroids, such as, for example, cortisol. Now, the way that our concentration of cortisol and other corticosteroids is maintained in our blood is via a negative feedback loop. And what that basically means is these corticosteroids, as the concentration of these steroids increases inside our blood, they can travel back up to our hypothalamus and they can basically inhibit the release of these molecules, specifically of ACTH.