And what that means is to bring those residues close together, that entire enzyme has to fold and form this particular three dimensional shape. And to fold and bring those residues that are far apart close together, we have to fold different ways and many times to basically form the active side. So it turns out the entire enzyme basically creates a scaffolding system that supports and stabilizes that small section, the active side that is actually used by the enzyme to catalyze that particular chemical reaction. So the active side is much smaller than the actual size of the enzyme. So the remaining portion of the enzyme acts to create, stabilize and support the active side by bringing the residues that are far apart closer together to basically catalyze the reaction and bind the substrate. Now, in addition, we can have other sites on the enzyme outside of the active side that also play an important role in actually regulating the functionality of that particular enzyme.