Now, we can go back to this state by the action of phosphor protein phosphatase which uses a water molecule to hydrolyze that ester bond and remove that inorganic phosphate reforming state A. So we can basically cycle it between state A and state B. So let's begin by looking at state A. So in the unphosphorylated state, the PFK two domain, this one is active while this one is inactive. And we said that when this one is active its function is to phosphorylate some type of molecule. Now what molecule will basically an intermediate in the process of glycolysis and also an intermediate in the process of gluconeogenesis.