And some of those bonds holding that segment together begin to break. Now, as that segment and that localized region on that protein becomes unstable because it is connected to other segments of that protein, it disrupts these interactions with the other segments, and that causes those other segments to basically break down as well. So we have one segment breaking down causes, let's say, a second segment to also break down. And that second segment, by breaking down, causes a third segment in close proximity to also break down. And so these different segments of the protein structure, as they begin to break down, they cooperate with one another to basically unfold that entire protein structure. And so eventually, because of this cooperative nature, we have this really sharp rise in the amount of protein that are denatured.