So we essentially took a tumor, we extracted cancer cells from that tumor and then we grew those cancer cells in a petri dish. Now, the cancer cells were exposed to some type of drug and what we saw happen was initially the drug carried out its effect and killed off some of those cancer cells. But over time, what happened was those cancer cells gained multidrug resistance MDR. And what that means is they gained the ability to not only resist that particular drug that we were using, but also resist closely related drugs to that initial drug that we began with. And that is what we call multidrug resistance, the ability to resist many different types of drugs. Now, the question was what exactly allowed these cancer cells to actually gain multidrug resistance?