And by the way, because the phosphatases turn off the activity of these pathways and that essentially decreases the likelihood that tumor growth will actually take place, these genes that code for phosphatases are also known as tumor suppressing genes. And the phosphatase themselves are known as tumor suppressing molecules because it's a result of these molecules that tumors do not actually develop. So phosphatases are called tumor suppressing molecules because they inactivate proteins and enzymes that drive that signal transduction pathway. And for this reason, we call the genes that code for phosphatases tumor suppressing genes. Now, what happens if both of these genes are for some reason inactivate or for some reason mutated or blocked? So it could be some type of chromosomal abnormality, so a deletion, an insertion, a movement to some other chromosome, and so forth.