In just a moment, it is stimulated to transfer a phosphoryl group from ADP from ATP onto the e one component of the complex and that essentially forms this phosphorylated state and that inactivates the activity of e one. So remember, the e one component of the complex actually catalyzes step one and step two of Pyruvate decarboxylation. It essentially stimulates the e one, stimulates oxidative decarboxylation of Pyruvate into that acetyl component to ultimately form that acetyl coenzyme A. Now, once we form this phosphorylated state, it is no longer active. But under certain circumstances we can inactivate the kinase and activate another molecule known as a phosphatase. So remember, phosphatase is our enzymes that reverse the effects of kinases.