So let's discuss low energy charge conditions. Remember that energy charge, loosely speaking is simply the ratio of ATP to A and P inside our cells. And so if we have low energy charge values within our skeleton muscle cells, we have a low ATP concentration relative to A and P. And what that means is our cells want to produce more ATP molecules and so they want to break down glycogen to glucose to use the glucose via glycolysis to form ATP. And so what happens is when the cell contains a low level of ATP compared to amp, the ANP adenosine monophosphate will actually act as an allosteric activator of phosphorase B. It will bind to an allosteric site on phosphorase B in the T state because the T state is the state that predominates for phosphorase B. And what it does is it basically shifts the equilibrium towards the r state.