What happens next is some type of group. For example, a phosphoryl group from the molecule A can be transferred onto the active side of that enzyme and that modifies that enzyme. And that's why we have this asterisk the start symbol on top of this intermediate. So in this intermediate, once we transfer the group onto the enzyme, we transform A into product C. And now the product C can be released from that complex. And so now we have this modified complex E with the star on top. Now, next, the second substrate B goes and binds into the active side of that enzyme to form this intermediate.