So all we want to do with our protein is change one amino acid in that protein to a different amino acid. How exactly can we carry out this process? Well, we can use a protein process in recombinant DNA technology known as side directive mutagenesis, also known as oligonucleotide directive mutagenesis. So proteins can be modified at a single amino acid by using this process we call side directive mutagenesis. Now, to demonstrate how this process works, let's suppose we have a protein and we want to change an amino acid glutamate to the amino acid aspartate in that protein. How exactly can we do this?