And now what happens? Instead of having allosteric activators, we have allosteric inhibitors that will bind onto isocitrate dehydrogenates and decrease its affinity for the isocitrate molecule. In fact, what will happen is the ATP molecules themselves will bind onto special region of ISOC citrate dehydrogenase and that will decrease the rate at which it will actually take place. On top of that, we also have NADH that will bind onto a special site of the isocitrate. It will kick off the NAD plus. And if there is no NAD plus bound to the isocitrate dehydrogenase enzyme.