Otherwise, we'll never find the water molecules inside the active side. And that means the environment in the active side is non polar. Now, what this microenvironment does is it brings the reactants very close together and it orients them in just the right orientation for that specific reaction to actually take place. And what it also does is it decreases the likelihood that other reactions take place and that decreases the likelihood that unwanted products are actually formed. So active sites typically create non polar microenvironments in which bonds can be formed and broken very easily. And unless water actually participates as a reactant in that biological reaction, it is usually excluded from that microenvironment from that active side.