So let's quickly go through each one of these reasons and let's begin with reason number one. So in the process of phosphorylation, what we actually do is we transform a neutral residue to a residue, modified residue that contains a negative charge. And because of the presence of the negative charge, it can basically break the old interactions and form better interactions, more stabilized interactions. And what that usually means is if this residue is found inside the active side of the enzyme, the presence of this modified phosphoryl group, what it basically does is it forms new interactions with, let's say, the substrate molecule. And that can in turn change the activity, the rate at which the enzyme actually catalyzes that particular reaction. So number one is this process gives a net negative charge and that's precisely what allows these new electric interactions to actually take place between this residue and that target substrate molecule.