Now, when the concentration of the substrate molecule is low inside the cell, the entire coordinary structure of the enzyme exists predominantly in the T state, the ten state. So what do we mean by the ten states? Well, in the ten state of this enzyme, the two catalytic primers and these are the orange structures in this diagram are basically found in close proximity with respect to one another, and they create a very compact and very constrained structure. And so what that means is the active sites in these catalytic triumphs are going to have a low affinity for that substrate molecules. And so at low substrate concentrations, the substrate molecules are not going to be likely to be bound to those active sites. And so that will create a low catalytic rate, a low catalytic activity.