So when we go between these two structures, the native state, the three dimensional functional state and our denatural state, that protein must actually follow these different intermediate structures. Now, an important point must be emphasized. So let's suppose we take the protein and we denature it once. So the first time around, it goes through this specific structure A, this specific structure B, and then it ends up in its denatured state. Now, let's suppose we reform this same native protein and now we denature it once again. So the second time around, that protein will not go through a molecule that looks exactly like B and it will not go through a molecule that looks exactly like A.