Now, once the binding takes place, now, these antigens that were released by the pollen particles can move on and bind onto the variable portion on our antibody as shown in this diagram in section five. And once this binding takes place these mast cells in the cytoplasm contain these granules, these tiny vesicles that carry special chemicals, special immune chemicals such as histamine. And once the antigen binds onto the antibody found on the membrane of these mast cells, these mast cells release these vesicles, these granules and in turn release the histamine and other immune chemicals. Now, what the histamine and these other chemicals do is they initiate an inflammation response and that dilates the blood vessels that carry blood to this area, to this infected area. So we say infected because this otherwise non harmful foreign substance was labeled as pathogenic by our immune system. And so this technically is an infected area to that particular individual because the immune system of that individual treats the pollen antigens as pathogenic.