And as they move, they rotate and they cause the dimers to also rotate and move. And that creates a quarterly change in the quarterinary structure of that molecule. And that causes it to basically go from the T state to the relaxed state. It basically becomes less constrained, more relaxed, and the affinity of the active sides for the substrate molecule increases as this actually takes place. So once again, as the substrate binds, in this case, as the poly inhibitor binds onto the active side, it causes the two trimmers to move farther apart and rotate, which in turn causes the regulatory subunits to also move. And therefore, the entire structure seems to expand upon the binding of that substrate molecule to the active side.