And the binding can either be covalent or non covalent. So all three types of these reversible inhibition processes are non covalent, but the Irreversible inhibition can be non covalent as well as covalent. So whenever you hear covalent bonding, that usually means Irreversible inhibition. So this diagram basically shows one form of Irreversible inhibition. So basically, we have this purple inhibitor binds to some location on the enzyme that blocks this substrate from binding onto the active side. And on top of that, this inhibitor, it will be very difficult to actually take that inhibitor off from our enzyme.