On top of that, the st fructose 26 bisphosphate that inactivates this actually activates this. So this molecule is activated by these two Alastairs effectors and pyruvate kinase is activated by the build up of fructose six bisphosphate. Now, why does that actually make sense? Well, if these two molecules activate the activity of phosphorptokinase, we're going to basically create many more fructose one six bisphosphate. And as this molecule builds up in the concentration, it will depend on pyruvate kinase to transform these ultimately into pyruvate. And so to basically make sure we don't have a continual buildup of the fructose one six bisphosphate, it creates a positive feedback loop and the f 15 bisphosphate molecule actually activates that pyruvate kinase and that activates the process of glycolysis.