So decreasing the PH, which is the same thing as increasing the H plus ion, has the same effect as increasing the temperature of our solution inside our capillaries. Now, what about carbon dioxide itself? So we already discussed the Bore effect, and we said that the majority of the carbon dioxide produced by the cells is absorbed by the red blood cells. And then those red blood cells convert the majority of that CO2 into H plus ions and bicarbonate ions. But actually, a small percentage of that carbon dioxide, when it actually enters the red blood cells, goes on directly to the hemoglobin and binds directly to the hemoglobin at specific regions. And once CO2 binds onto the hemoglobin, what it does is it decreases hemoglobin's ability to bind to oxygen.