For instance, if we have an embolism that takes place in the coronary artery that can lead to a heart attack and obviously, a heart attack is very, very dangerous. So there is a very, very fine line between thrombosis and hemorrhage. And to prevent either one of these from taking place and damaging our organs and tissues our body must be able to very precisely and very effectively regulate the coagulation cascade. And so previously, we discussed the activation of this process. Now we're going to discuss the inhibition. So how exactly do we down regulate and inhibit the different enzymes involved in the coagulation cascade process?