So, as always, we have the red blood cell, and this is the alveolus of our lung. Now, what's happening inside our lungs? Well, inside our lungs, the oxygen is moving down its concentration gradient from the alveolus and into the red blood cell. Now, by the Haldane effect, so again, we have this Haldane effect taking place. And by this Haldane effect, because we increase the concentration of oxygen inside our red blood cell, we decrease hemoglobin's ability to bind carbon dioxide and H plus ions. So as O two binds to hemoglobin, it basically decreases hemoglobin's affinity for H plus and CO2.