And once this complex is formed, no reaction will take place. And that's because once the inhibitor binds onto the enzyme substrate complex, it will keep that substrate inside that active side, and that active side will not be able to catalyze the transformation of that substrate into that particular product. Now, this leads us directly into point number one. Uncompetitive inhibitors actually decrease the VMAX value, and that's because they decrease the number of enzyme substrate complexes that are efficient, that are functional, that can actually convert the substrate into that particular product. So uncompetitive inhibitors bind to the enzyme substrate complex and decrease the total number of functional enzymes. And we can see how that affects VMAX by looking at this particular equation.