It reacts quickly to this rupturing within our blood, within our endothelial cell. So when the blood vessel ruptures it exposes a membrane glycoprotein on the damaged cell called the tissue factor TF which is actually attached to the membrane of that cell. Now TF binds to the active form of protein factor seven found in close proximity forming a dimer protein complex TF seven. This protein is a complex that is a serene protease. And now an inactive form of ten can come close to this complex and the complex basically lysis this or activates this inactive form into its active form. And the same thing is done with number nine, protein factor nine.