So when the IP three is cleaved, it is readily able to dissolve in that aqueous cytoplasm. And what it does is it moves on to a special ligand gated calcium ion channel that is found on the membrane of the endoplasmic reticulum. So this is one calcium channel, a second calcium channel. And so these IP three molecules, the nosatoll one, four, five triphosphates, go on and bind onto a special location on these ligand gated calcium channels. And when they bind, they cause a conformational change that opens up that internal passageway. And now what happens is because we have a high calcium concentration in the Er lumen and a low concentration in the cytoplasm, it causes these calcium ions to move down their electrochemical gradient from the lumen into the cytoplasm.