And once we form the enzyme substrate complex, that creates a conformational change that creates this brand new pocket, the allosteric site that the inhibitor can now bind to. Now, in the absence of the inhibitor, the enzyme substrate complex will simply form the product, and then the product will dissociate. But in the presence of the inhibitor, that inhibitor will bind onto that brand new allosteric site found on the enzyme substrate complex, and that will form the enzyme substrate inhibitor complex. And once this complex is formed, no reaction will take place. And that's because once the inhibitor binds onto the enzyme substrate complex, it will keep that substrate inside that active side, and that active side will not be able to catalyze the transformation of that substrate into that particular product. Now, this leads us directly into point number one.