And finally, in the EGF signaling pathway, we said that the GRB two must be able to bind and attach onto that EGF receptor to actually act as the adaptive protein and allow the attachment of the SOS. And only then can the SOS actually activate that Rasp protein which goes on to activate raft, which then goes on to activate the mex and the IRCS and so forth. So interactions play very important roles in these signal transduction pathways. And finally, we have termination. So all these pathways, even though they're very important in actually carrying out some type of physiological effect, they must be regulated and controlled correctly. Because if they are not regulated and controlled correctly, if they're not shut down at the proper times, they can cause damage to our body.