And that is they can release Renan independently without being stimulated by the maculodeensa cells. So basically, this apparatus, the juxtaglomero apparatus, contains special types of cells that can sense a drop in blood volume, a drop in blood pressure, and these cells release Renan into our blood system. So if we take a look at the following diagram, a low blood volume, a low blood pressure, and a low kidney perfusion rate basically positively stimulates the kidneys to produce and release our renal enzyme into our bloodstream. Now, at the same exact time, the liver, the cells inside the liver basically produce a xiaomogen enzyme known as angiotensinogen. Now, this is released into our bloodstream. And when this angiotensinogen mixes with our Renan, the Rena basically cleaves this zymogen at a specific location on that amino acid sequence and it activates the angiotensinogen into the angiotensin one form.