So we said that we could actually terminate the pathway by inactivating that receptor protein. In this case, it's the EGF receptor. Now, in some cases we see that over expression of these tyrosine kinase domains. So the tyrosine kinase receptors like the EGF receptor here, if the cell actually builds too many of these proteins and inserts too many of these proteins into the membrane of that cell, what that will do is increase the likelihood that the cell will activate the pathway at an inappropriate time. And so this access number, the excess amount of these receptors, the access amount of these receptors in a cell membrane can basically lead to the production of these cancer cells. So, overexpression of tyrosine kinase receptors can also lead to cancer of the epithelial cells.