And if the alphagy proteins cannot be activated, they cannot go on and activate those adenylus cyclaces. Now, under what conditions will the epinephrine actually dissociate? Well, let's use a bit of chemistry. Let's discuss Lusciously's Principle. So, according to Lucid Liar's principle, if the concentration of the free epinephrine molecules found in the surrounding area decreases. To basically compensate for that decrease in the free floating epinephrine concentration.