So if you remember, alpha one antitrypsin is that irreversible inhibitor that inhibits elastase as well as trypsin. Well, in the same exact way, antithrombin three basically binds to the acticide and inhibits the activity of thrombin. And by inhibiting thrombin, we basically inhibit the final common pathway and we inhibit the formation of blood clots. Now, antithrombin three can also form complexes with many other factors. So if we think back to the intrinsic pathway, we know that intrinsic pathway contains factor twelve, factor eleven, factor nine, and these three factors can also be inhibited by antithrombin three. And antithrobin three can also inhibit factor ten, which is basically that converging point between the extrinsic and the intrinsic pathway.