That means we no longer have the ability, this cell no longer has the ability to produce this MHC complex that is needed to actually display the self antigen. And in this particular case, our white blood cells. When they approach this otherwise healthy cell they will not notice those self antigens because the self antigens will not be able to bind onto the membrane because of the missing major histocompatibility complex. And therefore the wide blood cells will begin to attack these otherwise normal cells. So a genetic predisposition is believed to be one possible cause of autoimmunity. Research indicates that autoimmunity runs in the family or may run in the family and may be passed down to offspring from parent.