And so the hemoglobin inside the blood plasma must be able to unload and release that oxygen with a greater likelihood. So that also means that the hemoglobin must bind to oxygen much less likely in order for the oxygen to actually get into these exercising cells. And that's exactly why when we have a higher temperature of the blood plasma, the hemoglobin becomes less likely to actually bind to oxygen and much more likely to release and unload that oxygen into this exercising tissue. So, when these cells are carrying out more metabolic processes at a greater rate, we produce thermal energy. And that thermal energy essentially stimulates the hemoglobin to become much less likely to bind to oxygen so that they can unload that oxygen at a greater rate so that the cells can receive the oxygen they need to continue carrying out the metabolic processes. Now, the next question is how will this affect the oxygen hemoglobin dissociation curve?