And by interacting with the oxygen, they will create a conformational change in that substrate molecule. And by inducing that conformational change, they will create a shape. They will give the ATP molecule a shape that is appropriate for the shape of that active side. So we need the divilus metal atom to basically give the ATP substrate molecule the appropriate shape so that it can actually interim bind to the active side of that nucleocide monophosphate kinase. So before the NTP substrate, in this particular case, ATP can bind onto the active side of that kinase, the NTP must bind to a dive of metal atom such as magnesium or manganese. So what happens is two oxygens on this triphosphate interact with our magnesium atom so we have the alpha oxygens, we have the beta oxygens, these two, and then we have these are the gamma oxygens because this is the alpha phosphorus atom, the beta phosphorus atom and the gamma phosphorus atom.