So a mutation in the non coding region will not cause negative effects because the non coding region is not actually used to synthesize our proteins. But what about a mutation that takes place on the coating region? So he said that sometimes a mutation can take place, a point mutation can take place on our coating region and still not actually cause any harmful effect. It can still produce the same exact protein with the same exact structure and the same exact function. Well, the answer lies in the genetic code. Remember, the genetic code contains 64 codons, and we only have 24 amino acids.