And so once we eat, it's these liver cells that begin to secrete the insulin. And the insulin, as we'll see in just a moment, actually goes on and affects glute four. So let's finish with glute two. So this implies that because they have a high km value, they have a low affinity for the glucose substrate molecules and will only uptake the glucose at high blood glucose levels. So, after we eat a carbohydrate rich meal, now let's move on to glute four. So, glute four we actually find in our muscle cells and adipose tissue, so fat cells of our body, and the km value of these transporters is around five millimolar.