And that's because these contain areas of hydrophobic regions that can actually interact with the core hydrophobic region of that membrane, as we'll see in our discussion in just a moment. On the other hand, peripheral proteins cannot interact as well with that hydrophobic core of the membrane. And so these peripheral proteins can actually dissociate under certain processes. For instance, gap junctions that will typically find, let's say, between cardiac cells are examples of integral proteins. And these gap junctions do not actually dissociate from the cell membrane. Under normal conditions, we actually have to mix these integral proteins with some type of nonpolar solution, for example, a detergent to actually remove those integral proteins.