And as a result of the formation of these fibers inside red blood cells the healthy biconcave shape of the red blood cells will transform into this abnormal sickle shape. Now, what exactly will that do? Well, let's take a look at the following diagram. So we have this blood capillary and we have the deviation in the blood capillary as shown. Now, these are the normal healthy biconcave red blood cells and because of their bi concave nature they will easily and effectively be able to squeeze through the tiny capillaries of our cardiovascular system and they will not bind, they will not aggregate to one another. Now, when the red blood cells transform their biconcave shape into the sickle shape, these sickle shaped red blood cells will begin to aggregate and that can lead to clogging of these capillaries.