Cooperativity well, let's suppose we're going from this state to this state. So we essentially bump up our temperature. And once we increase our temperature, what begins to happen is a certain segment of that protein begins to become unstable. And some of those bonds holding that segment together begin to break. Now, as that segment and that localized region on that protein becomes unstable because it is connected to other segments of that protein, it disrupts these interactions with the other segments, and that causes those other segments to basically break down as well. So we have one segment breaking down causes, let's say, a second segment to also break down.