Another factor is temperature. So increasing or decreasing the temperature of our blood plasma can affect hemoglobin's ability to bind to oxygen and therefore affect the oxygen hemoglobin. This association curve. And this will be the focus of this lecture. Now, before we actually discuss how increasing or decreasing the temperature effect hemoglobin, let's discuss where this increase in temperature actually comes from. So, inside the cells of our exercising tissue, these exercising cells are carrying out more metabolic processes such as cellular respiration.