So what happens is the deprotonated aspartic acid, the aspartate shown here, uses its negative charge to transform the water into a better nuclear file. So we essentially create a hydroxide and then the protonated version of the residue, the spartic acid, uses the partially positive hydrogen to basically interact with that partially negative oxygen of the carbonyl. And that creates a good electrophile. And now the reaction can take place at a relatively high rate. Now, two examples of aspartate proteases that we're going to focus on in future lectures is Renmin, and this is basically the enzyme that is used to control blood pressure as well as pepsin. And this is one of the digestive enzymes that is found in our digestive system.