So we have a hole that forms in the membrane and that allows the blood to move from the lumen side and into the outside the tissue area, down its pressure gradient from a high pressure to a low pressure. Now, as soon as this endothelial cell is damaged, it will expose a special glycoprotein membrane known as TF, which stands for Tissue factor. Now, this glycoprotein wasn't there before. It's exposed only when we have this damaging taking place, when the endothelial cell is ruptured. Now, remember, we have all these other proteins floating around in close proximity. And as soon as the tissue factor is exposed on the membrane, what happens is another active form of another enzyme known as factor Seven, goes on and binds onto the tissue factor to form a dimer protein complex that now consists of two subunits known as tissue factor complex seven.