Now, once we initiate the process of DNA replication, how exactly do we actually synthesize those new data strands? So basically we use a protein known as DNA polymerase. What DNA polymerase does is it takes the free nucleotides that are found in the environment and it attaches these nucleotides by using phosphodia ester bonds. So basically it catalyzes. DNA polymerase catalyzes the formation of phosphol diester bonds. But before DNA polymerase actually begins the process of synthesis another protein enzyme known as primates, which is an RNA polymerase has to actually create something called the RNA primer.