So we have a low amount here, a high amount here. Energy will tend to move this way right from a high amount to a low amount until we reach thermal equilibrium, until the two sides have an equal amount of energy. And this describes the highest entropy, the highest mathematical probability of our system. Now, for every physical and for every biological reaction, these two thermodynamical laws must be obeyed. Now, we can even use these laws to explain many different reactions and phenomena that exist in biochemistry. For example, we can use the second law of thermodynamics to basically explain the hydrophobic effect.