And that will basically or that can cause damage and harm to the cells of our body. And so what happens is the buildup of the H plus ions essentially inhibits the activity of the third enzyme, phosphor Fructacion age, which essentially catalyzes the most important step, the commitment step of glycolysis. And if this enzyme is inhibited, that causes the inhibition of hexokinase and that essentially causes the process of glycolysis to stop. And so we're not going to be able to actually spring for very long for this exact reason? Because Glycolysis stops and our skeletal muscle tissue will not be able to get the ATP molecules that they actually need to continue the process of running. Now, this is especially important for those skeleton muscle cells which are found far away from the blood vessels.