What it depends on is the type of enzyme that we are dealing with. So the MACA's constant basically gives us information about the affinity or the traction of the enzyme to our substrate. So a very low Km value for any given enzyme means that the enzyme has a very high affinity for the substrate. Because a low Km means a small amount, a small quantity of concentration of substrate basically is required to fill up exactly half of our enzyme actives. And conversely, a high Km value, a high mecalus constant for a given enzyme means that we need a lot of substrate to actually fill exactly half of those active sites of our enzyme. So basically, these are the three factors that play a role in effecting the activity and the functionality of the enzyme.