That active side is actually quite small compared to the overall structure and size of that particular enzyme. The question is why? Well, if we examine the residues involved in the active side, those residues are usually found very far away, apart from one another on that primary sequence of the polypeptide chain. And what that means is to bring those residues close together, that entire enzyme has to fold and form this particular three dimensional shape. And to fold and bring those residues that are far apart close together, we have to fold different ways and many times to basically form the active side. So it turns out the entire enzyme basically creates a scaffolding system that supports and stabilizes that small section, the active side that is actually used by the enzyme to catalyze that particular chemical reaction.