And what that means is they have a very high affinity for the substrate molecule of the glucose. And under these normal blood concentrations of glucose, these two transporters are continually on and they're continually moving these glucose molecules down their concentration gradient. Now, let's talk a bit more about the glute three. So the glute three are these molecules that also generate the basal uptake rate, but we also find them predominantly in the nerve cells found inside our brain, in the neurons. We find them in the membrane of the dendrites, as well as the axons of the nerve cells of the brain. Now, why is it important that we have a high concentration of these glute three in the brain?