And what that means is this protein has to be positioned in the proper orientation so that the proper side can actually interact with the ATP molecule. And this has to be positioned in the proper orientation because we want to move the sodium this way and the potassium this way, and not in the opposite direction. And so we see that the proper positioning of this protein within the membrane determines its functionality. And this cell as a whole must be able to actually use the ATP and pump these in the proper directionality to basically establish that electrochemical gradient. And so we see that asymmetry is very important to the functionality of the cell membrane. Now, when we synthesize these proteins in the ribosomes of our cell, these proteins as well as lipids actually are placed into the membrane in an asymmetric fashion.