Let's suppose now our cells are contracting. And if the cells are contracting, we are using up ATP molecules and our energy charge value in the cell will drop. And if the energy charge value drops, we're going to have a relatively high concentration of molecules such as ADP. And the ADP adenine diphosphate will actually go on and inhibit the activity of kinase. In addition, Pyruvate will also inhibit the activity of kinase. And the kinase found on the E two component will no longer phosphorylate that Pyruvate dehydrogenase complex.