And because that active side is occupied, it cannot bind to substrate molecules and so it is not active. But if our concentration of cyclic Amp inside our body begins to increase, what happens is those CMP molecules will begin to bind onto these allosteric sites. And once bound to all four allosteric sites, that creates conformational changes that causes these pseudosubra sequences to dissociate from the active sites and that produces this R two complex. So notice that these two regulatory R subunits do not actually dissociate. They remain bound together. But these two green catalytic subunits basically dissociate.