It becomes more relaxed, so it becomes less constrained. And what that means is the active sites of the other active sites, which are unoccupied will basically increase the affinity for the substrate molecule and they will be much more likely to actually bind onto those Units. And what that means is, because we have more than one active site, those active sites will basically be able to interact with one another as a result of these structural changes that take place upon the binding of that substrate molecule to the active side of the enzyme. substrate molecules. And so ultimately, as more of the active sites become filled with those substrate molecules, the equilibrium basically shifts to the r state. And what that means is at a high concentration of substrate, when most of the active sites will be filled by the substrate molecule, all the enzymes will exist predominantly in the r state.