And that thermal energy transfers from a higher temperature to a lower temperature via the process of heat. And that's exactly why we sometimes refer to this thermal energy simply as heat. So, as the blood plasma receives more energy from the cells, more thermal energy, it essentially increases in temperature, because the particles and molecules and cells within our blood plasma gain more kinetic energy. So we increase the temperature of the blood plasma within our capillary. So, now that we know where the increase in temperature actually comes from, let's discuss how our increase in temperature actually affects the ability of hemoglobin to bind to oxygen. So the question is, what would we expect to happen to hemoglobin's ability to bind to oxygen when we increase the temperature of the blood plasma that contains the red blood cells that are carrying those hemoglobin molecules?