So number One or A hormones are no longer released and B, G proteins have an intrinsic GCPA activity which allows them to basically turn themselves off. Now, what also happens is in the cytoplasm we basically have these proteins known as phosphodiestases. And these phosphodiaesterases, what they do is they begin to basically transform the CA and P cyclic adenosine monophosphate molecules into Amp. Remember, in the Glucagon signal transduction pathway that initiates Glycogen breakdown, the canp acts as a secondary messenger that is used to basically activate the inactive protein kinase Apka into the active version of PKA. But now that we are no longer producing cyclic Amp as a result of the inactivation of the adenaline cyclist, and because the CA and P are being transformed into A and P, the PKA is no longer activated. Now let's move on to D. So in D and E, what we basically want to do is we want to inactivate the phosphoralase kinase that is needed to activate the Glycogen phosphorase and we also want to inactivate the Glycogen phosphorase that is ultimately needed in step one of Glycogen breakdown.