While when this goes from the loose state to the 10th state these two reactants are brought close enough for them to begin producing the ATP molecules and this structure. In the open state these reactants can easily leave and enter this structure. But once this conformational change takes place and we enter the loose state these two reactants are now trapped in this conformation. But even though they're trapped, they're not close enough to actually carry out that catalysis reaction and transform them into ATP molecules. So once we go from this drug to this structure, the ATP molecule actually leaves and now we have this empty spot. And so in the final step, what happens is once the ATP leaves the ADP and the orthophosphate can actually enter this location and the cycle can basically repeat itself again.