They bind to isocitrate dehydrogenase, and they turn off the activity of this enzyme. And so what that means is we cannot transform the isocitrate to alpha ketogrutrate. And so what happens once we turn off enzyme three? There is a build up of isocitrate, and Isacitrate is pretty much at equilibrium with citrate because this reaction is essentially at equilibrium. And so the isocitrate, once there's a build up of isocitrate, there will also be a build up of the citrate molecule. And the citrate molecule, as it builds up, it moves into the cytoplasm of our cells from the matrix of the mitochondria.