Now, what's the major difference between this protein here and this protein here? Well, one major difference is the fact that this protein consists predominantly of alpha helixes but in this case it consists predominantly it has a very high content of beta pleated sheets. So when this misfolding process takes place instead of forming all these alpha helixes we form these betappleted sheets. Now, what's the big deal about betappleted sheets? Well, because we have a high content of beta pleated sheets these molecules will have a high potential will have a high propensity of binding to other molecules that also contain beta pleated sheets. Why is that?