So we have 1234 of these regulatory sites that the cyclic adenosine monophosphate can actually bind to. Now, once that CMP binds onto all of these regulatory sites so we have four CMP molecules binding to four of these sites. What happens is that creates a conformational change that allows the R two complex. So this entire brown section to actually dissociate from these two green sections. And so what happens is these active sites which are occupied in the inactive form basically become unoccupied. They become free.