Let's discuss Lusciously's Principle. So, according to Lucid Liar's principle, if the concentration of the free epinephrine molecules found in the surrounding area decreases. To basically compensate for that decrease in the free floating epinephrine concentration. We know that the epinephrine that is bound will begin to dissociate and we see that this process takes place with great likelihood only when that epinephrine, the free epinephrine concentration is low. So one method of inactivation involves the epinephrine actually dissociating out of that cavity. Of that seven TM receptor shown here, this is the cavity and this is a seven TM receptor.