And so, in the next step, we are able to actually form that citral Co enzyme A. And once we form the citrus coenzyme A, that induces even more conformational changes that completely seal off these active sites. And by sealing off the active side, that basically prevents different types of competing reactions from actually taking place. So we see that in part four, the H plus ion of histidine 320 is given to the carbonyl group of the oxyloacetate, creating the strong, the good electrophile. Next, the pi bond of the ENL can act as a nuclear while taking the carbon of this oxylace, forming that intermediate, that citral coenzyme A. And once the citral coenzyme A is actually formed, that induces even more conformational change that essentially closes off and seals off the active side of the enzyme completely.