And that's precisely what gives it a potential to form many hydrogen bonds and that allows it to actually interact in a much more stabilizing fashion with that substrate molecule. Number three is these protein kinases can easily adjust the rate at which the reaction takes place and the rate really depends on the physiological conditions found inside the cell. Number four is we have an abundance of these high energy ATP molecules that exist inside our cells until we can quickly and effectively use them to actually transfer those phosphoryl groups. Number six is again with the ATP molecule because the breakdown, the defaults formation of the ATP molecule is in fact an exergonic process. It releases an ample amount of free energy. That free energy is used to basically drive this reaction.