So this implies that because they have a high km value, they have a low affinity for the glucose substrate molecules and will only uptake the glucose at high blood glucose levels. So, after we eat a carbohydrate rich meal, now let's move on to glute four. So, glute four we actually find in our muscle cells and adipose tissue, so fat cells of our body, and the km value of these transporters is around five millimolar. So it's not as low as these two and it's not as high as this. And actually, these glute four membrane proteins are sensitive to the insulin. So the insulin is able to actually stimulate these muscle cells and adipose tissue cells, so fat cells to express more of these glute four on the membrane of these cells.