And so here, no reaction takes place. Now, if the inhibitor departs, then we form this enzyme substrate complex, and only then can it go on to form that particular product. So unlike in competitive inhibition, and unlike in non competitive inhibition, in non competitive inhibition, what the binding of the inhibitor does is it lowers the turnover number of that enzyme, kcat. So remember, the kcat value, the turnover number represents the number of substrate molecules that can be transformed into the product molecules over some period of time by a single enzyme. And what this inhibition does is it decreases that turnover number. So essentially, the v max is lowered, the turnover number is lowered, but the km value, the Mikhaila's constant value, actually doesn't change in non competitive inhibition.