Now, once we form this phosphorylated state, it is no longer active. But under certain circumstances we can inactivate the kinase and activate another molecule known as a phosphatase. So remember, phosphatase is our enzymes that reverse the effects of kinases. They can use water to hydrolyze those bonds, releasing that inorganic phosphate and reforming this initial state of the molecule. And so in this state, the enzyme is active and can catalyze Pyruvate decarboxylation. So we see that the complex basically moves back and forth between the active and the inactive state.