And so what that means is because they are insoluble there is no way our cells and the body can actually break them down and denature them by the same method as it normally does. And because our cells cannot break them down eventually the aggregate proteins will somehow cause the death of the cell killing off the cells of our body and eventually that individual. So to gain some insight into how prions actually function let's take a look at the following molecule. The following protein that normally exists in the brain cells of our body, in our neurons, in the brain. So PRP, as shown in the following diagram is a normal protein that is found in the brain. And under certain conditions, for example, if some type of mutation takes place this protein can actually miss fold into this protein known as PrPSc.