So that will cause a medical condition we call hyperammonemia, high levels of ammonia inside our blood. Now, this is a very dangerous condition and it's especially devastating in infants who are born with defects in any one of these enzymes. So if an infant is born with the defect in any one of these enzymes, that will drive the levels of ammonium leading to this condition. Now, why is that dangerous? Well, we think that high levels of ammonium inside our brain can essentially change the zamotogradient between the inside and the outside of the cell because high levels of ammonium will essentially increase the levels of Glutamine, because the enzyme Glutamine synthetase found in the brain essentially combines the ammonium with Glutamate to form Glutamine. And high levels of Glutamine basically changes the somatic gradient.