And so that will result in excessive bleeding. Now, the other reason why the impairment of this factor aid is so negative is because thrombin actually uses this to create a very important positive feedback loop, as we discussed just a moment ago. So thrombin essentially depends on factor eight, on the presence of factor eight to create the positive feedback loop that greatly amplifies the number of factor ten that we actually activate. And that in turn amplifies how much of the blood clots we actually can form, how many of the blood clots we can form. So two important functions of factba eight. Factba eight interacts with proteolytic enzyme factor nine and stimulates it to basically go on and activate factor X, which is needed to ultimately coagulate the blood and form the blood clots because it's this molecule, factor X, that initiates the final common pathway that is used to form those blood clots.