And what these chemical agents do is they essentially decrease the ability of our immune system to actually fight off different infections including these grafts and organs that are transplanted into our bodies. So these chemical agents interfere with the processes of forming white blood cells. For example, they can interfere with the process of protein synthesis or DNA replication and that will greatly hinder the ability of our immune system to actually form any type of white blood cell. And so that suppresses the immune system and prevents it from actually mounting a defensive attack against that transplanted tissue or organ. Now, the major problem with this immunosuppression process is it's actually very dangerous. So as soon as we suppress our immune system we decrease its ability to find any type of to fight any type of infection.