When we mix it with bile, emulsification takes place, and we break down the fat globule into these individual molecules we call emulsion droplets. Inside these emulsion droplets, we still have many of these triglycerides molecules that we actually have to break down. But now the surface area greatly increases, and these pancreatic light based molecules can actually attach onto the surface of these emulsion droplets. Now, the question is, if our emulsion droplets are hydrophobic, and since our pancreatic lipase is hydrophilic, how exactly does the lipase bind onto the surface of our emulsion droplets? Well, basically, with the help of a special type of molecule known as colepase cholipase is amphithetic. It has a hydrophobic and a hydrophilic region.