In fact, the eight, or in some cases, factor eight is missing entirely. And so what that means is the impairment of factor eight greatly impedes this process, the intrinsic pathway. And if the intrinsic pathway does not function properly, we cannot amplify, we cannot create these blood clots quickly enough. And so what that means is once the blood vessel actually is cut, once the endothelium ruptures, the blood clots do not form at a high enough rate, and so excessive bleeding may occur. And this is exactly why hemophilia A is a bleeding disorder. So in individuals with hemophilia A, when they essentially cut a blood vessel, this is basically what takes place.