Now, where exactly do we find our desmosomes? Well, desmosomes are located in tissue that undergoes a constant state of stretching and experiences a constant state of pressure. And one example is the skin. So when I pull my skin, what basically keeps the cells together are our decimosomes, and what allows water not to get inside are basically the tide junctions. Another location of Desmondomes in is the intestinal tissue, and we'll see why they're important when we discuss the intestinal system. So, basically, in animal cells, there are three major ways by which our individual cells connect to one another.