And eventually he saw what happened is because this denatured enzyme was in the presence of oxygen, the oxygen in the air was able to basically reform those disulfide bonds. So it oxidized those disulfide bonds, reform those disulfide bonds. And eventually, because the urea was also removed at the same time, the non covalent interactions also reformed. And we reformed the proper secondary and tertiary structure of that particular enzyme. So initially, we place this native enzyme with access Beter mechatoethanol and ate molar urea. And what happens is our enzyme is denatured.