And then once factor twelve is activated it goes on to proteolytically activate factor eleven and that goes on to proteolytically activate factor nine. Now factor nine cannot by itself activate factor ten. What must happen is this protein that is not an enzyme. So factor eight basically interacts and stimulates this factor nine to go on and activate factor ten. And so ultimately what we see is this is the converging point of these two pathways. And these two pathways basically ultimately do the same exact thing.