Now the first way by which or the first method by which our body is able to actually shut down the Glucagon signal transduction pathway that initiates the Glycogen breakdown is to stop releasing the hormones that initiate this process in the first place. So in this particular case, it's glucagon. So Glucagon is no longer released. And what that means is glucagon can no longer act as a primary messenger and so this pathway will no longer be initiated. Now, the second method is the G protein. So the G proteins involved in this particular pathway, namely this G protein shown here, actually contains an intrinsic Gtpa's activity.