And what the phosphatases do is they essentially move onto the target proteins and they remove those phosphoryl groups that were placed by all these different protein kinases. For instance, these phosphatases can remove these phosphoryl groups here and that essentially inactivates this part of the pathway and so it cannot continue and as a result it is shut down. And so anywhere I have an asterisk, that basically means we're dealing with a protein kinase. And so these phosphatases can influence and shut down this protein, these proteins, these proteins and also these two structures here which are actually part of that EGF receptor. And finally we can terminate the pathway by inactivating that receptor of the pathway. And actually we already spoke about one way by which we can inactivate is by removing these phosphoryl groups.