So this is the carbon dioxide, the nonpolar carbon dioxide, and this is the terminal residue, the amino terminal residue. So, in the presence of a special enzyme, this is basically transformed into the following group known as the carbonate. So this carbonate contains a negative charge. And just like we form salt bridges, in this case, this can also form, the carbonate can also form a salt bridge, thereby stabilizing the entire T state structure of the deoxy hemoglobin. And by the same token, the stabilization of the deoxy hemoglobin's T state also shifts the curves to the right side, thereby decreasing the affinity of hemoglobin for oxygen and allowing to actually unload more o two molecules to the exercising tissue of our body. So this entire discussion basically is known as the Bore effect.