And once inside the matrix, before the pyruvate molecules can actually enter the citric acid cycle, they must be activated. And the way that we activate the pyruvate molecule is by removing a carbon dioxide and taking the remaining two carbon components of the pyruvate, known as the CETO group, and placing it onto a carrier molecule known as coenzyme A COA. So at the end of pyruvate decarboxylation that takes place in the matrix of the mitochondria, we form the CETO coenzyme A complex. Now, this activates the molecule and allows it to actually enter the citric acid cycle. So we see that pyruvate decarboxylation actually is the connection. It's the link between Glycolysis and the citric acid cycle of aerobic cell respiration.