So the phosphorusati three kinase contains a regulatory region, shown here, that attaches onto the phosphorylated residue of the IRS molecule. And once this attachment takes place, that causes the active side of this lipid kinase to move in in close proximity with respect to the membrane. So this is the active side of this phosphor nosetide kinase. And once that active side moves there, it causes the phosphorylation of a specific type of fat molecule that exists within the membrane known as Pip two. Now, when did we see Pip Two previously? Well, we actually spoke about Pip Two in our discussion on the phosphornosatide cascade.