But the hydrophobic effect is that predominant force. So, as I mentioned earlier, most proteins exist in aqueous solutions and most proteins form in aqueous solutions. And what that basically means is we have the hydrophobic effect that takes place. So remember, what the hydrophobic effect tells us is if we take non polar molecules, hydrophobic molecules, and place them into a solution where water is that dominant molecule, because water is a polar molecule, what will happen is we'll find that those non polar molecules will basically aggregate together to form larger systems, larger chunks of nonpolar molecules. And that's because that system that is formed is thermodynamically stable. Now, what does that have to do with the folding of the proteins and the formation of the tertiary structure?