Next, the glucose six phosphate is transformed into glucose one phosphate by the activity of phosphor glucom Utase. Now, once we form the glucose one phosphate, we want to activate the molecule, make it much more reactive and increase its energy. And so what we do is we use UDP glucose pyrophosphorylase to basically transfer a group from UTP onto the glucose one phosphate and that kicks off a Pyrophosphate, as shown in this diagram. So we generate the UDP glucose and the Pyrophosphate. Now this reaction isn't really product favored. And to make it product favored to drive the formation of UDP glucose, the Pyrophosphate is cleaved by water into two orthophosphate molecules.