Now, the problem with Serene in this form shown here, is the side chain of Serene is in its alcohol form. And we know from organic chemistry that alcohols aren't very good nuclear files. So the problem here is this alcohol is not a strong nuclear file. And in the form we have it now, it will not be good enough nuclear file to attack that peptide bond. And so what must happen is the histidine and the aspartate must work together to transform this serine into a strong nuclear file. So what we essentially want to do is transform the alcohol into its conjugate base, valcoxide.