It activates factor eleven, it activates factor eight and it activates factor five. And this process amplifies, it produces even more of these dimer complexes that are needed to produce these blood clots. So Thrombin goes on to factor eleven, it takes the inactive form and it activates it. And what factor eleven does is it goes to activate factor nine and that ultimately creates more of these dimers as shown in this diagram. Now, Thrombin also activates factor eight. And factor eight essentially circulates in our blood and it attaches to this VWF factor, which basically stands for a Von Villebrand factor.