For example, if a given hemoglobin molecule is bound to two carbon monoxide, that means only two oxygen can actually bind onto the hemoglobin versus the four oxygen in the normal case. So what this does is it decreases the oxygen carrying capacity of the hemoglobin inside our blood plasma, and that's why we have the drop in this curve. And that means, because we have a decrease in oxygen carrying capacity, once again, less oxygen will be ultimately delivered to the tissues of our body. So, two effects are in place. We have a drop in the curve, which is a result of the actual binding of the Co to our hemoglobin. It decreases the oxygen carrying capacity.