So we essentially see that these ligand gated ion channels respond to the binding of special types of stimulating molecules. In this particular case, these transmembrane proteins, which also allow the movement of these ions across the cell, a membrane, respond to a change in the electric potential difference between the two sides of the membrane. So in a change of the membrane voltage, So let's suppose this is some particular voltage gated ion channel. For instance, one Voltage gated ion channel that We're Going To focus on in detail is the Sodium Voltage gated ion channel. And this voltage gate ion channel exists across the axon membrane of neurons, and it plays a very important part in actually generating and propagating action potentials along the exxon of that neuron. So this is our sodium voltage gated ion channel.