And the coenzymes are usually vitamin derivatives. So we have two main types of coenzymes. So coenzymes can be further subdivided into these two groups. We have the Co substrates, which are basically coenzymes that bind to our enzyme via loosely held bonds while our prosthetic group is basically the coenzyme that binds to the enzyme via tightly held bonds for example, Covalent bonds. So let's discuss in more detail what the difference between these Cofactors are. So metal ions include the minerals such as magnesium, zinc and potassium and so forth while our coenzymes are basically vitamin derivatives and this includes biotin and Thiamin Pyrophosphate.