Aside from temperature and carbon dioxide. Another fact that that influences and affects hemoglobin's ability to bind oxygen and therefore affects the oxygen hemoglobin dissociation curve is something known as two three bifoxoglycerate, or simply two, three BPG. So two, three BPG is a three car carbon sugar that is an intermediate in the process of glycolysis. So when we break down sugar, specifically glucose, into Pyruvate molecules to form ATP, in the process of cellular respiration, we essentially form the two three BPG as an intermediate. Now, when our cells are exercising, when they have a relatively high rate of metabolism, they can produce an excess amount of two, three BPG. And some of these two three BPG molecules can ultimately leave these exercising cells and enter the capillaries that are found next to these exercising cells.