So the Delta S of our system is negative. Now, we know, according to thermodynamics this is only possible if this reaction releases enough energy to compensate for that decrease in entropy. And this is exactly what happens at room temperature or at body temperature inside our cells. This reaction is actually spontaneous because even though the entropy of the system decreases, there's so much heat, so much energy released into the surroundings that that increases the entropy of the surroundings by a greater amount than the decrease of the entropy of the system. And so what that means is the change in entropy of the Universe is positive. Because if this is greater than this, then this is a positive value.