Now, the majority of these spleen cells will not have the ability to actually build that antibody of choice, but some of these will be the plasma cells that produce the antibody of choice. And so, as we'll see in step three, we're going to want to screen these different types of plasma cells and we want to find those plasma cells that basically produce that particular antibody of interest. Now, in the second step, what we want to do is now we want to transform them into cancer cells. And the way that we transform these normal spleen cells, healthy spleen cells, into cancer cells is by mixing them with the multiple myeloma cancer cells. So if we mix these orange cancer cells with these normal purple cancer cells, the two types of plasma cells will essentially fuse in a solution of polyethylene glycol. And once they fuse, we essentially transform these healthy plasma cells in purple into these cancerous plasma cells known as hybridoma cells.