Now, antithrombin three can also form complexes with many other factors. So if we think back to the intrinsic pathway, we know that intrinsic pathway contains factor twelve, factor eleven, factor nine, and these three factors can also be inhibited by antithrombin three. And antithrobin three can also inhibit factor ten, which is basically that converging point between the extrinsic and the intrinsic pathway. It's the beginning of that final common pathway. So we see that antithrombin three is a glycoprotein that resembles the structure of alpha one antitrypsin. Now it binds with very high affinity to thrombin and it activates its activity and it also blocks it forms complexes with other factors of the intrinsic pathway and the final common pathway.