But if we have plenty of ATP inside our body, the cell must signal somehow for the citric acid cycle to actually decrease its activity. In fact, it also has to signal for glycolysis to actually decrease its activity. And so what happens is ACP and NADH act as allosteric inhibitors. They bind to isocitrate dehydrogenase, and they turn off the activity of this enzyme. And so what that means is we cannot transform the isocitrate to alpha ketogrutrate. And so what happens once we turn off enzyme three?