And these H plus ions and CO2 ions can actually bind to the allosteric site found on hemoglobin. And once they bind, they create a conformational change, a change in the three dimensional structure of hemoglobin. And what this does is it decreases the ability of hemoglobin to actually bind to oxygen. And by decreasing our hemoglobin's ability to bind to oxygen, we ultimately shift the entire oxygen hemoglobin dissociation curve to the right, as seen in the following diagram. And this is known as the Bore Effect. So by increasing the concentration of carbon dioxide, we ultimately increase the concentration of H plus ions, and that makes our blood more acidic.