Now, before we discuss this medical condition and before we actually discuss what causes it, let's remember the blood clot in cascade and what it actually is. Well, whenever there is some type of trauma inside our blood vessel, so, for example, we have a cut or we have some type of rupture in the endothelium of a blood vessel in our cardiovascular system that basically initiates the blood clot and cascade. And what the blood clot cascade is and what it does is so it basically consists of these many proteins and enzymes that work together to coordinate the formation of blood clots. And these blood clots are basically mesh like networks of these individual fiber molecules that basically create the mesh like structure that ultimately forms the blood clots. And these blood clots can basically coagulate and they can seal off that rupture, that cut, and that prevents the leakage of blood out of that blood vessel and into that surrounding tissue. Now, if we actually examine the blood clot in cascade, we'll see that there are two important pathways.