And what that means is we will not amplify the effects, the formation of the blood clots. We're not going to be able to form as many blood clots as we want. We're not going to be able to form them quickly enough. And so that will result in excessive bleeding. Now, the other reason why the impairment of this factor aid is so negative is because thrombin actually uses this to create a very important positive feedback loop, as we discussed just a moment ago. So thrombin essentially depends on factor eight, on the presence of factor eight to create the positive feedback loop that greatly amplifies the number of factor ten that we actually activate.