So on top of using the energy charge value to help us determine which process predominates, the glucose levels in our blood can also be used to actually tell us which one of these two processes actually predominates glycolysis or gluconeogenesis. Now, the key element in this regulatory pathway, which is once again a reciprocal regulatory pathway and we'll see what that means in just a moment. The key element in this pathway is a bifunctional allosteric enzyme that contains two different types of domains. Now, Bifunctional simply means it has two different functions. In fact, the functions are essentially opposite functions and that's why we call it reciprocal. Now, allosteric means it contains special sites that combine allosteric effect or molecules that can basically affect the activity of that protein.