And notice that this ligand, the primary Messer, binds onto this region on the outside. And once it binds, it creates a conformational change that in some cases basically causes a portion of that protein on the intracellular side to basically detach. And that can lead to other processes as we'll see in lectures to come. So this is basically step number two. The formation of that receptor primary messenger or ligand complex is what we call step two. And what happens in step two is that message that is stored in that primary messenger is now transduced passed down to that cell.