And under such conditions, the CETO coenzyme A will act as an allosteric inhibitor. It will bind onto the e two component of this complex and that will inhibit the activity of that complex. Likewise, NADH is also an Alstairic inhibitor to the complex because it binds onto the e three location of the complex. Also in activating its ability to actually catalyze this pyruvate decreboxylation step. Now, in addition to these regulatory pathways in eukaryotic cells, such as the cells of our body, we also have another important regulatory method. We actually use a type of covalent modification, namely for sporulation, to actually regulate the activity of this complex.