Now, blood plasma consists predominantly of water molecules, and water is polar. And because glutamate is polar, glutamate has no problem interacting with the water molecules. And so that creates no problem because that glutamate would much rather interact with the polar molecules than any other nonpolar molecule. So the beta subunits of the normal hemoglobin, as shown in the following diagram, have a polar residue at a six position. And that means the glutamate has no problem interacting with the polar water molecules found in close proximity. Now, let's take a look at this diagram.