Likewise, if we increase the concentration of the enzyme we have more active sites and so more likelihood that the substrate will be transformed into the product. And finally, what about KCAD divided by Km? What exactly is the meaning behind KCAD divided by Km, the rate constant of this reaction? Well, it turns out that this is what we actually use to measure the catalytic efficiency of enzymes. So how enzymes or how efficient are enzymes in catalyzing a certain type of substrate? So let's remember what Kcat means and let's remember what Km means because if we remember what these two quantities mean individually, we can then basically decipher what the meaning is behind this ratio.