I can tell you a few things about artificial sweeteners!
Alot of artificial sweeteners look nothing like sugar (in terms of their chemical makeup) and have very different properties.
Most are also sweeter than sugar (sometimes by a factor of hundreds)
so in the packets, you will find that they come along with alot of other, inert ingredients.
I found this link for you that lists various artificial sweeteners and their properties.
Since most of them are nothing like sugar, you can't do certain things to them: such as heating to high temperatures or for example caramelizing.
The link I gave you mentions which artificial sweeteners are safe for eg.
baking and includes some natural subsitutes as well.
I'm not really familiar with their health aspects, but I found this link that discusses health issues with artificial sweeteners.
Hope this is useful to you!
cooking.stackexchange.com/users/94/Kryptic
For baking I try to use honey instead of sugar where ever I can.
However, honey is expensive so I use for recipes that needs lots of sugar rather brown or raw sugar.
For cooking honey works very well too.
It often even enhances the overall flavour when a good honey is used.
I personally do not use artificial sweetener.
I don't like the taste, and I am not sure if it is shown that they do not have unintended side-effects.
Especially, aspartame is very controversial in this sense.
cooking.stackexchange.com/users/62/txwikinger
The various artificial sweeteners and stevia can in general not be used to feed yeast or produce caramel.
Most are much sweeter than sugar.
They are controversial in regards to health effects, but then so is sugar.
The various "raw" sugars can have very different flavor profiles, as an example dark muscovado sugar often imparts a licorice note.
Agave syrup is somewhat "in" because of relatively low GI and should be added to the list.
cooking.stackexchange.com/users/1220/Krister Olsson
Splenda, besides giving you the runs, is very hard to bake with.
My wife had gestational diabetes so we tried baking with splenda and nothing turned out right.
Splenda has no nutritional value.
Raw sugar is great, but it has a slightly different taste than processed sugar, similiar to brown sugar.
Artificial sweetners would probalby have similar issues to splenda, but I've never tried them outside of sweetening tea.
cooking.stackexchange.com/users/61/Bryant
There's a lot of variety, mainly depending on whether you want something else
that's sweet or something that's sweet and has no calories.
Honey, molasses, maple syrup, brown sugar, raw sugar, cane sugar, and (per above) date syrup are all sweet and caloric.
Honey, molasses, maple syrup and date syrup are more viscous (goopy).
Brown sugar is just regular sugar mixed with molasses.
Raw sugar is like granulated sugar but not bleached.
As for non-caloric sweeteners, you have splenda, xylitol, reb-a (Truvia), erythritol, stevia, and aspartame.
Splenda is made from sugar and the most similar functionally, although it's not identical.
Xylitol is natural but has a cooling aftertaste that doesn't work well in many dishes.
Rebiana is chemically similar to stevia's active compound and sounds good but doesn't work as well as it says; it's also mixed with fillers and erythritol.
Erythritol is a form of fermented glucose.
Stevia is a plant extract that has great sweetness but a lingering aftertaste; some preparations add bulk, but the liquid itself is much sweeter by volume than sugar.
Aspartame (nutrasweet) is chemical death, and I recommend you cut it out of your diet.
cooking.stackexchange.com/users/1443/Ocaasi
Artificial sweeteners - particularly those that are "zero-calorie" - are mostly fillers such as dextrose anyway.
Depending which particular filler they use, it may cause unexpected results in your recipe.
Under the Splenda brand they offer a bulk product that (they claim) can be used interchangeably for sugar in cooking and baking.
We typically use it half-and-half with real sugar.
cooking.stackexchange.com/users/106/GalacticCowboy
Use glucose sugar for confectionary making as it does not cause crystalisation as you will find occurs if you use normal cane sugar
cooking.stackexchange.com/users/15392/Doug Sewell
Such as:   Splenda  Artificial Sweeteners  Sugar "In the Raw"  Honey  Stevia  Molasses   Can they be used interchangeably in recipes or do they have to be used at different proportions?Aside from nutritional differences, can I expect drastically different flavors?
What are the advantages and disadvantages of various sugars/substitutes?
cooking.stackexchange.com
<substitutions><sugar>
cooking.stackexchange.com/questions/266
cooking.stackexchange.com/users/123/Ryan Elkins
Honey, syrups and raw, brown or cane sugar can be used for cooking, and often enhance the flavour. Artificial sweeteners and Stevia are often far sweeter than sugar and are hard to bake with. In general, they cannot be used to feed yeast or make caramel. Glucose syrup is good for confectionary making as it does not crystallise like sugar. Artificial sweeteners are generally not good for baking and are much sweeter than sugar. Only honey, raw and brown sugar are god for cooking.
Most artificial sweeteners are a lot sweeter than sugar. Honey is a good choice for baking except for glucose syrup which is good in confectionary making. Artificial sweeteners are hard to bake with Raw, brown and cane sugar are all sweet and have a lot of calories. They also have a slightly different taste.