### Question
Can you define what significant nexus means?


### Answer
**Significant nexus** is defined as the following in *40 CFR § 401.11*:

> that a water, including wetlands, either alone or in combination with other similarly situated waters in the region, significantly affects the chemical, physical, or biological integrity of a water identified in paragraphs (l)(1)(i) through (iii) of this section. 

#### Citation:
  - *40 CFR § 401.11*
  - Heading: **Title 40—Protection of Environment > PART 401—GENERAL PROVISIONS > CHAPTER I—ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)**

