### Question
How is the term major change defined?


### Answer
The term **major change** is defined in *21 U.S.C. § 350a* as the following:

> given to such term in section 106.30(c)(2) of title 21, Code of Federal Regulations (as in effect on August 1, 1986), and guidelines issued thereunder.

#### Citation:
  - *21 U.S.C. § 350a*
  - Heading: **CHAPTER 8-NARCOTIC FARMS > SUBCHAPTER IV-FOOD**

