### Question
How is the term supplement defined?


### Answer
The term **supplement** is defined in *21 U.S.C. § 379g* as the following:

> a request to the Secretary to approve a change in a human drug application which has been approved

#### Citation:
  - *21 U.S.C. § 379g*
  - Heading: **CHAPTER 9-FEDERAL FOOD, DRUG, AND COSMETIC ACT > SUBCHAPTER VII-GENERAL AUTHORITY > Part C-Fees > subpart 2-fees relating to drugs**

