### Question
What does significant nexus mean?


### Answer
**Significant nexus** has the following meaning in *40 CFR § 300.5*:

> that a water, including wetlands, either alone or in combination with other similarly situated waters in the region, significantly affects the chemical, physical, or biological integrity of a water identified in paragraphs (1)(i) through (iii) of this definition. 

#### Citation:
  - *40 CFR § 300.5*
  - Heading: **Subpart A—Introduction**

