### Question
What is the definition of significant aggravation?


### Answer
The definition of **significant aggravation** is as follows in *42 U.S.C. § 300aa*:

> any change for the worse in a preexisting condition which results in markedly greater disability, pain, or illness accompanied by substantial deterioration of health

#### Citation:
  - *42 U.S.C. § 300aa*
  - Heading: **CHAPTER 6-THE CHILDREN'S BUREAU > SUBCHAPTER XIX-VACCINES > Part 2-National Vaccine Injury Compensation Program > subpart d-general provisions**

