Definition: Compose a new way to ask the same question. The new question must be asking the exact same thing as the original question does. Without any other information, you should be able to tell that the original question and the new question are the same. Preserve bracketed phrases in your new question. You can change the rest of the question provided the above requirements are satisfied. The new question must have a natural, fluent formulation, as if it were composed by a native English speaker. You will be given three pieces of information to help you create better questions. Those are: "Answer": the answer to the question, e.g., "Honolulu". "Answer Type": the type of the answer, e.g., "Location". "Auxiliary Information" is a detailed description of some concepts mentioned in the question, if any.
Input: original question: Which disease or medical condition has been targeted by the trials of [Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder]?
answer: bipolar i disorder
answer type: Disease or medical condition.
auxiliary information: The purpose of this study is to compare the efficacy and safety of SPD417 in treating bipolar manic symptoms, when given once daily in the evening vs. twice daily.

The trials of [Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder] targeted what medical condition or disease?