Definition: In this task, you're given a statement and three sentences as choices. Your job is to determine which sentence can be inferred from the statement. Incorrect choices change the meaning in important ways or have details that are not mentioned in the statement. Indicate your answer as 1,2, or 3 corresponding to the choice number of the selected sentence.
Input: Statement: The leptin breakthrough spurred efforts to manipulate the brain's hunger centers. Choices:  1. Efforts to manipulate the brain's hunger centers have been spurred.  2. The leptin breakthrough is the missing link scientists have been searching for. 3. There have never been any efforts to manipulate the brain's hunger centers.

1