Definition: Given the Question and Answer pair, detect whether the answer is acceptable or not. Denote acceptable answer as "yes", otherwise denote as "no". An acceptable answer is consistent with the context in question, detailed, long, and uses general knowledge of English. Answers that are not definite and suggest a variety of options are not acceptable answers.
Input: Question: When it comes to cities and boats named after saints, it seems that "Santa" is always female and "San" is always male. e.g. Male Saints: San Diego, San Francisco, San Antonio Female Saints: Santa Barbara, Santa Maria So why isn't "Santa Claus" a woman like all the other "Santa"s? 
Answer: The city names you quote are all derived from Spanish, where "San" (or "Santo", as @tchrist clarifies below) is the male inflection and "Santa" the female one. However, Santa Claus isn't derived from Spanish, but from Dutch, where it was originally rendered as Sante Klaas, and was modified to Santa when it was adopted into English (and from English, to the rest of the world). Here's Etymonline's take on it: from dialectal Dutch Sante Klaas, from Middle Dutch Sinter Niklaas "Saint Nicholas," English, like all other languages, borrows words from many sources, and they often carry over remnants of their original grammar or usage, even when it makes for inconsistent usage in English.

yes