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Input: "The conventional approach to developing flu vaccines today is one in which we perform surveillance worldwide " said David Topham  director of the New York Influenza Center of Excellence and professor of microbiology and immunology at the University of Rochester in New York.
"We collect the viruses that are circulating in people " said  Topham  who was not involved in the new study . Those viruses then typically are studied in ferrets    he  said.
"We create an antigenic map of each virus and determine how similar or different that is than the (current) vaccine strain  and if it's different enough from the vaccine strain then we select that virus to be in  next year's vaccine " Topham  said. In other words  they make their best guess on what strains will be most likely to spread and cause illness based on surveillance data
On the other hand  the new study suggests "using high-throughput sequencing methods and genetic engineering to rationally design a virus to use as a vaccine "  he  said. "I thought it was a very innovative and comprehensive approach."
The new study acted like "rocket science" compared with the conventional approach used to develop flu vaccines   he  said.
So what does the future hold for flu vaccines and where could this new approach fit in? There has been a shift among researchers around the world to focus on developing universal vaccines   Topham  said.
"These  for influenza  would be vaccines that would last for at least five years and protect against 75% of the viruses that are out there "  he  said. "There are many ways that we might be able to achieve that. This approach that's described in this paper is just one approach."

Flu vaccine: Could this be a better way to build one?