Definition: Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.
Input: Abstract: Recent evidence shows tetracyclines have anticollagenolytic activity that may be clinically effective in disease treatment. This led us to use systemic tetracycline (oral tetracycline hydrochloride 1 g daily divided into 4 doses) as adjunctive therapy in treating 18 patients with persistent corneal epithelial defects. Fourteen of 18 patients healed their defects; within 48 hours (9 patients) and within two weeks (the other 5 responding patients). Two patients showed no effect and two showed disease progression.

Systemic tetracycline hydrochloride as adjunctive therapy in the treatment of persistent epithelial defects.