Definition: In this task, you're given a statement, and three sentences as choices. Your job is to determine which sentence clearly disagrees with the statement. Indicate your answer as '1', '2', or '3' corresponding to the choice number of the selected sentence.
Input: Statement: The test may make them think twice about medicines that take the fun out of patients' lives. Choices:  1. All of the test-takers are well prepared for the test. 2. They are taking a medical test that could cover medicine's effect on patients. 3. There are no medicines with negative effects on patients' lives.

3