Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Using immunohistochemical techniques, we examined major histocompatibility complex (MHC) antigen expression on astrocytes, oligodendrocytes, and macrophages-microglia derived from surgically resected tissue from young adults and maintained in dissociated cell cultures supplemented with either fetal calf or human AB serum. The majority of these cells in culture expressed class I MHC antigens. MHC class II expression was observed on only a restricted proportion of astrocytes either under basal or induction conditions (,/-interferon, activated lymphocyte supernatants), on the majority of macrophagesmicroglia under inducing conditions, and not on oligodendrocytes. MHC class II expression on astrocytes in culture did not correlate with the extent of in situ gliosis or with in vitro cell morphology. MHC antigen expression was not detected in situ immunohistochemically. These data extend observations on the dissociation of in vivo and in vitro expression of MHC antigens on glial cells. The apparent greater expression of MHC class II antigens on macrophages-microgha compared to astrocytes raises the issue of the relative roles of each of these cell types in promoting immune reactivity under pathologic conditions. mechanisms contribute to lesion formation in some chronic demyelinating diseases of the CNS induced by viral infection in animals, and are postulated to participate in the pathogenesis of the human chronic demyelinating disease, multiple sclerosis (MS). The above pathologic conditions are characterized by accumulation of lymphocytes, macrophages-microglia, and reactive astrocytes in the region of demyelination. The contribution of each of the cell types present in the region of these lesions to promoting ongoing immune reactivg~y remains under active study. A major consideration with regard to specific cell types either promoting antigen-specific immune reactivity or becoming targets of antigen-0165-5728/89/$03.50

Immunohistochemical studies of adult human glial cells