Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Objectives: The aims of this article were: to summarize the pharmacology, pharmacokinetics, and efficacy of daptomycin; to explore its safety profile', and to discuss its current and potential roles as an antimicrobial therapy Results: Phase III study results suggest no difference in efficacy or tolerability between daptomycin 4 mg/kg IV QD and vancomycin or semisynthetic penicillins for complicated skin and skin-structure infections. Animal studies suggest daptomycin may be useful for the treatment of endocarditis. Daptomycin is not indicated for pneunionia, with poorer outcomes than conventional treatnient. It is available as an IV niedication and exhibits 92% plasnia protein binding in vitro. In healthy adult humans, daptoniycin has a volume of distribution of 0.1 Ukg and a plasma elimination half-life of -9 hours, and is eliminated primarily by renal excretion (-54%). In patients with reduced renal function, including those receiving hemodialysis and peritoneal dialysis, the dose interval should be 48 hours. No dosage adjustnient appears to be necessary for mild to nioderate hepatic impairnient. The use of daptomycin in patients with severe hepatic irnpairnient has not been assessed. The niost comnionly reported adverse events include constipation, nausea, injection-site reactions, headache, and diarrhea. Patients should also be nionitored regularly for skeletal niuscle toxicity. Conclusions: Daptoniycin may be useful for complicated skin and skin-structure infections and gram-positive pathogens resistant to conventional antimicrobials. However, limited data are currently available for duration of treatment beyond 14 days and at doses >4 mg/kg QD. (Clin Ther.

New Drug Daptomycin: A Cyclic Lipopeptide Antimicrobial Agent