Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Background: current tools to predict the severity of respiratory syncytial virus (RsV) infection might be improved by including immunological parameters. We hypothesized that a combination of inflammatory markers would differentiate between severe and mild disease in RsV-infected children. Methods: Blood and nasopharyngeal samples from 52 RsVinfected children were collected during acute infection and after recovery. Retrospectively, patients were categorized into three groups based on disease severity: mild (no supportive treatment), moderate (supplemental oxygen and/or nasogastric feeding), and severe (mechanical ventilation). clinical data, number of flow-defined leukocyte subsets, and cytokine concentrations were compared. results: children with severe RsV infection were characterized by young age; lymphocytopenia; increased interleukin (IL)-8, granulocyte colony-stimulating factor (G-csF), and IL-6 concentrations; and decreased chemokine (c-c motif ) ligand (ccL-5) concentrations in plasma. The combination of plasma levels of IL-8 and ccL-5, and cD4 + T-cell counts, with cutoff values of 67 pg/ml, 13 ng/ml, and 2.3 × 10 6 /ml, respectively, discriminated severe from mild RsV infection with 82% sensitivity and 96% specificity. conclusion: This study demonstrates that the combination of cD4 + T-cell counts and IL-8 and ccL-5 plasma concentrations correlates with disease severity in RsV-infected children. In addition to clinical features, these immunological markers may be used to assess severity of RsV infection and guide clinical management.

cd4 + t-cell counts and interleukin-8 and ccl-5 plasma concentrations discriminate disease severity in children with rsV infection RSV Monoinfection Is Associated With Disease Severity, Irrespective of Viral Load