Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the chicken MHC is simple and compact with a single dominantly expressed class I molecule that can determine the immune response. In addition to providing useful information for the poultry industry and allowing insights into the evolution of the adaptive immune system, the simplicity of the chicken MHC has allowed the discovery of phenomena that are more difficult to discern in the more complicated mammalian systems. This review discusses the new concept that poorly expressed promiscuous class I alleles act as generalists to protect against a wide variety of infectious pathogens, while highly expressed fastidious class I alleles can act as specialists to protect against new and dangerous pathogens. An enormous body of knowledge about the MHC and MHC molecules has been amassed over the past 50 years, mostly due to work on humans and important biomedical model species like mice [1]. This information is extremely detailed, complex but well integrated, and crucially important both for basic scientific understanding of immune and autoimmune responses and for practical medical applications, including transplantation [2, 3] . What is the point of trying to understand the MHC in non-mammalian vertebrates, when there is such rich and relevant knowledge for placental mammals? Highlights

Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens