Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: We report in this work that a cellular and humoral autoreactive response can be induced against liver-speci®c self-determinants by repeated immunization with a chimeric tissue-speci®c selfantigen carrying a heterologous T h epitope. Epitope spreading rendering the autoimmune reaction independent of the presence of the cognate heterologous help is also demonstrated. Although neutrophil in®ltrates can be demonstrated in the livers of treated mice, no clinical sign of organ damage is observed. These ®ndings suggest that breakage of tolerance by this means leads the process only up to the next checkpoint in the progression of autoimmune disease and that further events are required to precipitate functional organ impairment.

Lack of patent liver autoimmunity after breakage of tolerance in a mouse model