Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: We have synthesized and characterized a series of compounds containing the 3azatetracyclo[5.2.1.1 5,8 .0 1,5 ]undecane scaffold designed as analogs of amantadine, an inhibitor of the M2 proton channel of influenza A virus. Inhibition of the wild-type (wt) M2 channel and the amantadine-resistant A/M2-S31N and A/M2-V27A mutant ion channels were measured in Xenopus oocytes using two-electrode voltage clamp (TEV) assays. Most of the novel compounds inhibited the wt ion channel in the low micromolar range. Of note, several compounds inhibited the A/M2 V27A mutant ion channel, one of them with submicromolar IC 50 . None of the compounds was found to inhibit the S31N mutant ion channel. The antiviral activity of three novel dual wt and A/M2-V27A channels inhibitors was confirmed by influenza virus yield assays. Amantadine; cage compounds; influenza A virus; M2 proton channel; drug design c MCC: minimum cytotoxic concentration, or concentration producing minimal alterations in cell morphology after 72 hr incubation with compound. d CC 50 : 50% cytotoxic concentration, as determined by the MTS cell viability test. Values shown are the mean of 2-3 determinations. J Med Chem.

3-Azatetracyclo[5.2.1.1 5,8 .0 1,5 ]undecane derivatives: from wild- type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant NIH Public Access