Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: ABSTRCT 29 Given the scale and rapid spread of severe acute respiratory syndrome coronavirus 2 30 (SARS-CoV-2, known as 2019-nCov) infection , the ongoing global 31 SARS-CoV-2 outbreak has become a huge public health issue. Rapid and precise 32 diagnostic methods are thus immediately needed for diagnosing COVID-19, 33 providing timely treatment and facilitating infection control. A one-step reverse 34 transcription loop-mediated isothermal amplification (RT-LAMP) coupled with 35 nanoparticles-based biosensor (NBS) assay (RT-LAMP-NBS) was successfully 36 established for rapidly and accurately diagnosing COVID-19. A simple equipment 37 (such as heating block) was required for maintaining a constant temperature (63°C) 38 for only 40 min. Using two designed LAMP primer sets, F1ab (opening reading frame 39 1a/b) and np (nucleoprotein) genes of SARS-CoV-2 were simultaneously amplified 40 and detected in a 'one-step' and 'single-tube' reaction, and the detection results were 41 easily interpreted by NBS. The sensitivity of SARS-CoV-2 RT-LAMP-NBS was 12 42 copies (each of detection target) per reaction, and no cross-reactivity was generated 43 from non-SARS-CoV-2 templates. Among clinically diagnosed COVID-19 patients, 44 the analytical sensitivity of SARS-CoV-2 was 100% (33/33) in the oropharynx swab 45 samples, and the assay's specificity was also 100% (96/96) when analyzed the clinical 46 samples collected from non-COVID-19 patients. The total diagnosis test from sample 47 collection to result interpretation only takes approximately 1 h. In sum, the 48 RT-LAMP-NBS is a promising tool for diagnosing the current SARS-CoV-2 49 infection in first line field, public health and clinical laboratories, especially for 50 resource-challenged regions. 51

Title Page: 1 Reverse transcription loop-mediated isothermal amplification combined with 2 nanoparticles-based biosensor for diagnosis of COVID-19 3 4 Laboratory of Pediatric Respiratory Infection Disease, National Clinical Research