Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Background: SARS-CoV entry into target cells is a unique and complex process. Results: Cell entry mediated by SARS-CoV S was strongly inhibited after knockdown of PI4KB. Conclusion: PI4KB is required for SARS-CoV S-mediated entry, and this function is dependent on its kinase activity. Significance: Our results indicate a new function for PI4KB and suggest a new drug target for preventing SARS-CoV infection. Further research suggested that PI4P plays an essential role in SARS-CoV spike-mediated entry, which is regulated by the PI4P lipid microenvironment. We further demonstrate that PI4KB does not affect virus entry at the SARS-CoV S-ACE2 binding interface or at the stage of virus internalization but rather at or before virus fusion. Taken together, these results indicate a new function for PI4KB and suggest a new drug target for preventing SARS-CoV infection.

Phosphatidylinositol 4-Kinase III␤ Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry *