Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Herpes simplex virus (HSV) isolates derived from the central nervous system of ten patients with HSV-l-induced encephalitis, one patient with multiple sclerosis, and 14 patients with HSV-2-induced meningitis were investigated for neurovirnlence by assaying the LDs0 after nose and intracerebrai (i.c.) inoculation of mice. HSV-1 encephalitis strains were significantly more virulent after nose inoculation (i.e. neuroinvasive) when compared with HSV-1 isolates from patients with oral lesions only, whereas HSV-2 meningitis strains were significantly more virulent after i.c. inoculation when compared with HSV-2 isolates from patients with genital lesions only. No correlation between high neurovirulence (defined as low LDs0 for both routes of infection) and replication in cell cultures of neuronal and non-neuronal cell lines was found, but the weakly neuruvirulent HSV-1 strain isolated from a patient with multiple sclerosis gave low replication yields. After nose inoculation, a highly neuroinvasive HSV-1 laboratory reference strain replicated to high titers in nose tissue, the trigeminal ganglia and brainslem, while a strain with low neuroinvasiveness but high i.c. virulence replicated less well in the brains|era. Neuroinvasiveness of the virus strain might be one factor of relevance in the pathugenesis of HSV-1 encephalitis in man.

Neurovirulence of Herpes Simplex Virus Types 1 and 2 Isolates in Diseases of the Central Nervous System