Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Background: Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Therefore, we tested in this study the concept of using S1P as a target to block efficient virus replication. We demonstrate that stable cell lines inducibly expressing S1P-adapted a 1 -antitrypsin variants inhibit the proteolytic maturation of GP-C. Introduction of the S1P recognition motifs RRIL and RRLL into the reactive center loop of a 1 -antitrypsin resulted in abrogation of GP-C processing by endogenous S1P to a similar level observed in S1P-deficient cells. Moreover, S1P-specific a 1 -antitrypsins significantly inhibited replication and spread of a replication-competent recombinant vesicular stomatitis virus expressing the Lassa virus glycoprotein GP as well as authentic Lassa virus. Inhibition of viral replication correlated with the ability of the different a 1 -antitrypsin variants to inhibit the processing of the Lassa virus glycoprotein precursor. Conclusions/Significance: Our data suggest that glycoprotein cleavage by S1P is a promising target for the development of novel anti-arenaviral strategies. Citation: Maisa A, Strö her U, Klenk H-D, Garten W, Strecker T (2009) Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted a 1 -Antitrypsin Variants. PLoS Negl Trop Dis 3(6): e446.

Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted a 1 - Antitrypsin Variants