Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Foot-and-mouth disease virus (FMDV) leader protein (L pro ) is a papain-like proteinase, which plays an important role in FMDV pathogenesis. L pro exists as two forms, Lab and Lb, due to translation being initiated from two different start codons separated by 84 nucleotides. L pro self-cleaves from the nascent viral polyprotein precursor as the first mature viral protein. In addition to its role as a viral proteinase, L pro also has the ability to antagonize host antiviral effects. To promote FMDV replication, L pro can suppress host antiviral responses by three different mechanisms: (1) cleavage of eukaryotic translation initiation factor 4 γ (eIF4G) to shut off host protein synthesis; (2) inhibition of host innate immune responses through restriction of interferon-α/β production; and (3) L pro can also act as a deubiquitinase and catalyze deubiquitination of innate immune signaling molecules. In the light of recent functional and biochemical findings regarding L pro , this review introduces the basic properties of L pro and the mechanisms by which it antagonizes host antiviral responses. © 2015 Liu et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/

Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses