Definition: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
Input: Aim of this study was to de termine and furthe r characte rize the se rum aminope ptidase -M in childre n with live r dise ase s. Based on our ne w assay, we have shown two fractions of the e nzyme . Activity of the ® rst fraction is e xpre sse d in undilute d se rum at pH adjuste d from 8.5 (pH of storage d se rum) to 7.4. Activity of the se cond fraction (cryptic activity) appe ars in the serum (pH 7.4) as a result of dilution and/or addition of aniline naphthale ne sulfonic acid. In childre n with Alagille syndrome , e xtrahe patic biliary duct atre sia, Byle r's dise ase , and acute hepatitis due to he patitis B virus infection, activitie s of both fractions are highly elevate d as compare d to healthy childre n or those with chronic viral he patitis. More over, se rum aminopeptidase -M se ems to re¯e ct othe r aspe cts of the pathological proce ss than those re¯ected by the alanine aminotransfe rase and g -glutamyltranspe ptidase . Due to incre ase d activity and broad substrate speci® city, the e nzyme se e ms to be also a cofactor of chole stasis and he patitis.

Further Studies on Aminopeptidase-M in Blood in Children with Cholestatic Liver Diseases and Viral Hepatitis