 [ Symptoms ] left flank pain but colonoscopy and cystoscopy found nothing what could be causing the pain   [ Disease ] significant weight loss can also affect the fat pads around your cheeks and eyes creating a hollowedwrinkled appearance your next step other than regaining your weight would be to have an evaluation by your plastic surgeon or dermatologist your surgeon may recommend fillers fat transfer or stem cell micro injections to restore volume to your face