 [ Symptoms ] what are the long term side effects of depo provera  i used depo provera as birth control for several years now i started when i was 19 and love that i have no period i stopped for about a year and tried the patch which i did not care for when i got back on the depo i gained a bit of weight my symptoms include fatigue muscle soreness and weakness high blood pressure and weight control issues most of the fat is around my waist i believe the hormonal cycle may be effecting my health a lot and need to know my other options now 29 [ Disease ] many of the symptoms you describe are vague and could be due to a number of things including provera some of the common side effects of this medication include weight gain weak bones headaches fatigue swelling these symptoms could also be caused by a number of things such as thyroid problems its best to see your doctor to get evaluated and to discuss your concerns regarding contraception there are many options available