 [ Symptoms ] i have the single transverse palmar crease on one hand does that mean i carry the downsyndrome gene even if i am not ds also does having this crease mean if i get pregnant my baby will be at risk of having down syndrome i do not have down syndrome and there is no history of it in my family but i have the crease and wondering if it will mean those questions i just asked [ Disease ] just wondering if he has ever had any problems with his heart that was the first thing that came to mind when i read your comment could be something more simple though i would keep trying to find out what is wrong i would get a second or even third opinon if needed <positive_smiley>