 [ Symptoms ] is there any over the counter medicine for severe headaches besides excedrin migraine that makes you jittery [ Disease ] excedrin migraine is a nonprescription medication that contains acetaminophen aspirin and caffeine each excedrin migraine tablet contains 65 mg of caffeine the label will direct you to take 2 tablets at one time which is about the same as drinking 1 to 1 12 cups of coffee anacin is another nonprescription pain reliever that contains caffeine 32 mg as well as aspirin the label suggests 2 tablets of anacin as well which would be like drinking a little less than 1 cup of coffee