 [ Symptoms ] will a cortisone shot cause indigestion or heartburn [ Disease ] corticosteroid injections commonly are given to relieve pain in the joints such as the elbow or the neck the medication works by reducing inflammation which in turn can relieve pressure on a nerve and reduce pain a corticosteroid shot for joint or soft tissue pain should not cause any side effect like indigestion generally speaking the medication stays in the local area of the injection and does not travel throughout the body corticosteroids also can be administered by injection into a vein this type of injection is used to treat an allergic reaction or asthma while it is unlikely this type of steroid injection would cause indigestion it is not impossible if you received a cortisone shot for joint pain then your heartburn likely is not related hope this helps