 [ Symptoms ] how is anemia diagnosed [ Disease ] the lack of intimacy can be very complicated so i think it would be good to address the issue as a couple during one of her counseling sessions you may need to convince her to do this the cause could be related to her depression of course but can also be related to her self image many antidepressant medications can affect libido so a review of her medications may be in order perhaps changing some of them to a type that does not have sexual side effects you and your wife can rediscover sexual intimacy again but it may take time patience and some sexual counseling do not give up on her or be frustrated this can be fixed