 [ Symptoms ] can long term use of psych meds cause memory loss [ Disease ] psych meds is a pretty broad category that is hard to generalize about lithium is well known to cause problems with short term memory and associative fluency though stopping lithium or sometimes lowering the dose usually reverses this nardil is not known to cause cognitive problems and in fact antidepressants in general are not associated with cognitive problems other than the tricyclics which have anticholinergic effects