 [ Symptoms ] my girlfriend took 400mg ibuprofen this morning and 400mg tylenol at 6 est can she take either again  migraines and a bit of a tooth ache still from a removed impacted premolar [ Disease ] ibuprofen can be given every six hours tylenol can be given every four hours while i am not a fan of using both many clinicians allow their patients to do it and many people safely do it on their own personally i think just one or the other is sufficient but migraines assuming she has a true medically diagnosed migraine not all bad headaches are migraines then she may need to take something stronger something different or at least a more appropriate dose i assume that your girlfriend is an adult with an adult weight so a consultation with her medical provider would seem a appropriate do not take more than the recommended maximum adult dose of either one of these over the counter medications