 [ Symptoms ] is it safe to take st john is wort while taking lipitor [ Disease ] st john is wort has the potential to decrease the efficacy of lipitor so it is not suggested that you take st john is wort with lipitor without consulting your health care professional as a pharmacist i generally steer my patients away from st john is wort it is taken for depression and depression is a condition that should not be self treated it requires a thorough evaluation and the help and advice of a professional