 [ Symptoms ] can a vaginal yeast infection irritate the area around the urethra  i was recently treated in the er for a severe infection from a finger injury that was speading up to my wrist i was given 2 antibiotic injections and home course of two oral antibiotics within a few days i began showing vaginal swelling irritation and itching after finishing the pills i have the typical yeast discharge and the area around the urethra is red swollen and tender can this cause other problems and travel up the urethra [ Disease ] yeast can most definitely irritate the urethra if you have a vaginal yeast infection use a topical yeast cream and smear on this area as well this can even be mixed with some 1 hydrocortisone cream to help with the irritation it is not likely to travel up your urethra but it can definitely irritate this delicate tissue