 [ Symptoms ] i have been on depoprovera for 4 months for the last month i have been spotting often what could be happening [ Disease ] this is a good question you can always ask your pharmacist an increase in appetite and weight gain are side effects of prevacid if you have gained a reasonable amount of weight i would suggest speaking with your health care provider if you need to stay on the medication you will probably need to make some lifestyle changes including diet and exercise