 [ Symptoms ] is frolic acid necessary when taking vitamin b12 1000 methylcobalamin daily i currently take 1000 mcg b12 methylcobalamin daily now i am reading you should combine it w frolic acid is it necessary to add [ Disease ] it depends on why you are taking it if it is for b12 deficiency then you take vitamin b12 but with a doctor is guidance to monitor blood levels if you are taking it for high blood levels of homocysteine or to prevent age related macular degeneration then you take a combination of b12 folic acid and pyridoxine for more information on dosing side effects and interactions see this link