 [ Symptoms ] why does not hydrocodone show up in your urine  i take 4 10 mg hydrocodone pills a day and i have tested negative on the last two urine test at my doctors office so they had to send it off for testing the last time i had 3 pills within a 6 hour period and it had been about 2 hours from my last pill and i still tested negative how is this possible [ Disease ] severe infections can occur in the large intestine but they are uncommon ulcerative colitis is also associated with a higher risk of colon cancer for that reason doctors recommend frequent colonoscopy examinations your doctor may discuss other risks with you