 [ Symptoms ] is toe twitching numbness in hand and weak arms a sign of ms  my three toes beside my big toe on my left foot twitch at random times and it only lasts a couple of minutes but no matter what i do i cant stop it this happens a few times a month also my right hand goes numb at least 4 or 5 times a day i have noticed the past month or so that my arms are becomming so extremely weak i can barely change my 2 year old is clothes anymore becaue my arms get so weak and my muscles in my arms hurt there is probably a rational explination for all of these symptoms right [ Disease ] yes i am sure there is a rational explanation for this the problem is you will not get that explanation unless you see a medical professional for a physical exam before i jumped to a conclusion of multiple sclerosis ms i would think in terms of less scary explanations like a problem with a disc in your neck that might account for the arm weakness muscle twitching can be caused by several things including a mild potassium deficiency is the toe twitching related to the arm weakness maybe maybe not your primary health care provider is in the best position to start putting all the pieces of this puzzle together because he or she knows your medical history current medications and supplements and so on i would suggest you call and make an appointment to get the ball rolling toward a diagnosis meanwhile i would not get too worried about this being something scary like ms we will both hope it is something easily explained and easily treated wishing you all the best