 [ Symptoms ] i have had a sore throat for 4 days and it is not strep with no other symptoms could it be throat cancer [ Disease ] if you are a smoker or have other risk factors cancer of the throat is always a possibility but with a sore throat for only four days    one that is strep negative    the most likely culprit is a plain ol respiratory virus these viruses tend to last a week so hang in there a bit longer if your sore throat persists consider getting a blood test for mono andor see an ent for an exam if you are a smoker stop smoking