 [ Symptoms ] is sudafed pe for sinus headache safe for pregnant women [ Disease ] before using over the counter products during pregnancy it is especially important to talk to your ob gyn andor your pharmacist pain relievers such as acetaminophen are generally safe during pregnancy and may help with sinus headaches if congestion is a major issue it is safest to use a nasal spray that works locally rather than taking a pill that will travel throughout your system talk with your health care professional before taking anything while pregnant