 [ Symptoms ] glipizide vs metformin as a medication for type 2 diabetes  i understand that glipizide stimulates the production of more insulin by the pancreas in order to control blood sugar levels in type 2 diabetes that metformin helps to decrease insulin resistance helping the body to absorb the sugar taking it out of the blood faster which is better will the pancreas eventually stop production of insulin from constant over stimulation by taking glipizide daily is there a down side to metformin also [ Disease ] i would see an ent an ear nose and throat specialist for consultation on possible tonsil removal oral rinses may help but it sounds like an ent issue