 [ Symptoms ] i completed at 14 day round of prilosec otc two weeks ago is it be ok to start another 14 day round [ Disease ] this is a great question if you have completed a 14 day round of prilosec otc and your heartburn is not resolved you need to see a health care provider for additional evaluation if you heartburn is resolved you should continue to use dietarylifestyle modifications you should only repeat the 14 day treatment course of prilosec otc every four months if needed