 [ Symptoms ] sprained left ankle for a year and a half ligament injury synovitis with effusion [ Disease ] unfortunately there is no easy or natural solution for deep laugh lines and forehead wrinkles you may start with topical retinoid creams which are vitamin a derivatives you can get them from your dermatologist or over the counter as retinol creams however your best results may be obtained with botulinum toxin injections andor laser skin resurfacing