 [ Symptoms ] is it safe to take 1000 mg tylenol 500 mg ibuprofen and 675 mg of aspirin 4 5 times a day  i am 56 years old and i have had two strokes i have pain in my knees lower and upper spine due to damage and arthritic pain in various joints i also tend to get sinus headaches almost daily in other words i am in constant pain some days cold & damp worse than others my doctor has me taking 1000 mg acetominaphen 500 mg ibuprofen and 675 mg aspirin 4 to 5 times a day is this safer than taking 5 mg vicodin 4 5 times a day [ Disease ] see your gynecologist there could be a discoverable reason why you are having painful sex so you will not have to use emla an anesthetic cream