 [ Symptoms ] what time of day is best to take an anti depressent can it be taken with my rx for hypothyroid  i have been taking 25 mcg of synthroid for over a year i started taking 10 mg of lexapro in january and can not decide if i should take my synthroid in the morning and lexapro at night or if they should be taken at the same time i have gained about 10 pounds since starting lexapro and am finding it difficult to lose as i have no energy and feel tired all the time [ Disease ] i do not know i guess you will just have to wait and find out cannabis is fat bound can can be detected for several weeks but this is variable depending on the amount you use and how well your body eliminates it variable some urine tests are more sensitive than others too