 [ Symptoms ] what medications can cause a false positive on a psa test [ Disease ] several medications can decrease psa values but i am not aware of any that can raise psa medications that can decrease psa and thus possibly cause a false negative test include • finasteride and dutasteride these treat enlarged prostate finasteride is also used for male pattern baldness • anti inflammatory medicines also called nsaids this includes naproxen and ibuprofen • acetaminophen or tylenol • statins to treat high cholesterol • water pills or diuretics things that can increase psa values include • bph or enlarged prostate • prostate cancer • prostatitis infection of the prostate • recent sexual activity • recent urological procedures like cystoscopy • long distance bike riding if your psa value is elevated you should see a urologist and find out what is causing it find out more information about psa testing in the prostate cancer health center