 [ Symptoms ] very cold and unable to warm up  i have been very cold for several days now to the point of shaking and unable to warm up even with multiple blankets and heaters the only time i can seem to get relief is in a hot shower [ Disease ] hi that looks like a separate issue may be there is no relation between your knee pain and your loss of appetite and fatigue… if your knee is locking out you should see an orthopedist to exclude a torninjured meniscus otherwise you can make some laboratory investigations as cbc and esr to rule out other pathology if found do your knees become hot is it one or both knees what aggravates the pain