 [ Symptoms ] can expressing gratitude towards my partner improve our relationship [ Disease ] the short answer to your question is yes the hydrocodone could possibly be contributing to your husband is sleeplessness i would suggest he go back to his health care provider and discuss his medications again to determine if this is the case hydrocodone is an opioid medication usually opiod medications depress certain central nervous system functions such as breathing typical side effects of opioid medications include sleepiness however a few people might experience what is called a paradoxical reaction to an opioid pain reliever this means their body responds in an opposite fashion to the drug so instead of becoming sleepy from taking an opioid for example a person could become stimulated instead it is not possible to diagnose a paradoxical reaction through a forum like this only your husband is health care provider can determine if this is happening with your spouse your husband should not stop taking the hydrocodone abruptly because this can have unpleasant side effects instead he would be well served to see his health care provider as soon possible to re evaluate his medications sorry you are going through this i hope it gets resolved quickly