 [ Symptoms ] how is crohn is disease different from ulcerative colitis [ Disease ] while ulcerative colitis causes inflammation only in the colon colitis andor the rectum proctitis crohn is disease may cause inflammation in the colon rectum small intestine jejunum and ileum and occasionally even the stomach mouth and esophagus the patterns of inflammation in crohn is disease are different from ulcerative colitis except in the most severe cases the inflammation of ulcerative colitis tends to involve the superficial layers of the inner lining of the bowel the inflammation also tends to be diffuse and uniform all of the lining in the affected segment of the intestine is inflamed unlike ulcerative colitis the inflammation of crohn is disease is concentrated in some areas more than others and involves layers of the bowel that are deeper than the superficial inner layers therefore the affected segments of bowel in crohn is disease often is studded with deeper ulcers with normal lining between these ulcers