 [ Symptoms ] large hard mass in the back of my neck is it a sign of lymphoma [ Disease ] com multidrug resistant tb is when tb is resistant to more than one anti tb drug and at least isoniazid and rifampin drug resistant tb can occur when the drugs used to treat tb are misused or mismanaged if she does not complete a full course of tb treatment dictors prescribe the wrong treatment the wrong dose or length of time drugs are of poor quality the most important way to prevent the spread of it is to take all tb drugs exactly as prescribed by the specialist no doses should be missed and treatment should not be stopped early