 [ Symptoms ] my husband is taking neurotin and percocet his father gave him three otc sleep aids last night is it ok to mix them [ Disease ] without knowing the exact medication his father gave him it is really hard to say whether or not the combination is safe for your husband to take keep in mind while over the counter medications are readily available safety is still important there are still drug drug interactions that can occur toxicities with taking too much and it is important to take medications whether prescription or over the  counter for the right reasons most over the counter sleep aids contain diphenhydramine as the active ingredient if he was given 3 pills he could have taken too much another thing to keep in mind is that many sleep aids contain a pain reliever such as acetaminophen or ibuprofen if he is taking percocet which contains oxycodone and acetaminophen he could be taking too much acetaminophen which can be very toxic mixing over the counter medications with prescription medications is not as simple as one would think it is really important to check with a medical professional to make sure there is no duplication or drug drug interactions