 [ Symptoms ] i recently burned my upper thigh really bad now it is itching it is keeping me up at night how can i stop the itching  i burned my upper thigh with boiling soup the emergency room said it was almost 3rd degree in some places it has been 2 weeks since the incident and now it itches so bad it is driving me crazy i need to sleep how can i stop the itching [ Disease ] i am so sorry to hear you are going through this burns can be very painful and the healing process can be uncomfortable too it is important not to scratch or pick at the burn site while it heals because this can lead to scarring i hope the emergency room gave you some written instructions on how to care for your burn here is a link to a webmd article about burn care but this mainly refers to mild burns to your question if the itching is keeping you up at night and assuming you are a healthy individual you can try taking an over the counter antihistamine such as benadryl diphenhydramine it not only will calm down the itching but will make you feel drowsy read the label instructions very carefully and take this only as directed i hope you are receiving follow up care for your burn please see your health care provider regularly until it is fully healed your provider will be able to provide specific instructions on how to care for your burn feel better soon