 [ Symptoms ] what is the relationship between estrogen and postpartum depression [ Disease ] having the blues after childbirth is so common it is considered normal however 10 to 25 of women experience a major depression within the first six months after childbirth the abrupt drop in estrogen after delivery seems like the obvious culprit    but this link has never been proved postpartum depression is treated like any other depression with antidepressants therapy or both some preparations of estrogen do show promise as a potential add on to these established treatments