 [ Symptoms ] ive been on depo for 6 mnths now an after reciving my last shot i got sick what does this mean  i have been moody and some mornings i do not eat or i can not keep my food down from the night before really scared i have been healthy all my life be side of sport injuries [ Disease ] moody and loss of appetite does not necessarily mean it was caused by the depo provera injection there are hundreds of things that can cause these vague symptoms it may have just been a coincidence that the symptoms began after you last injection if the symptoms persist see your medical provider for a proper examination do not just assume it was the depo