 [ Symptoms ] prescribed prednisone five 10 mg once daily for 2 days do i take 5 at once prednisone 10mg tablets 5tablets by mouth once daily for 2 days then 4 for 2 days then 3 for 2 days then 2 for 2 days then 1 for 2 days my question is do i take the dosage i e 5 tablets at one time or through out the day [ Disease ] it may be best to take them all at once in the mornings they can keep you awake