 [ Symptoms ] is it safe to take hydroco 5325 and 5mg xanax  i was in an auto accident and broke my anklefoot wrist and had internal abdomonal injuries and was prescribed hydroco 5325 for pain i also suffer from anxiety and panic attacks and have been taking 5 mg of alprazolam per day are these two medications safe to take at the same time i take 1 hydroco 5325 tablet every 4 6 hours for pain and take 5mg alprazolam per day [ Disease ] it is definitely safe you want to be careful to see how they interact with each other at a time when you can lay down if necessary i take four 1 mg xanax a day and two 7 5325 mg of norco hydrocodone everyday make sure your doctors are aware of your medical history and all medications