 [ Symptoms ] why does ibu profen cause ankle swelling  my husband takes a lot of ibu profen for back pain and arthritis pain lately his ankles are swollen and itchy it is not pitting edema they are not discolored it has been 2 weeks he is in general good health [ Disease ] severe infections can occur in the large intestine but they are uncommon ulcerative colitis is also associated with a higher risk of colon cancer for that reason doctors recommend frequent colonoscopy examinations your doctor may discuss other risks with you