 [ Symptoms ] does prednisone oral have longterm side effects i took prednisone and methotrexate for 5 years for a virus [ Disease ] tonsils that have an abscess can certainly burst severely enlarged tonsils from mono may seem deflated once they retreat back to their pre mono size i have no way of seeing your tonsils as you know so i cannot blindly determine if what you are seeing is normal or not you would need to see your medical provider for an examination