 [ Symptoms ] i have two holes in my chest that blow bloody bubbles when i breathe [ Disease ] mania symptoms to some degree occur during depressive syndromes in about 23 of people with bipolar i or ii disorder depressive symptoms likewise often occur during manic or hypomanic episodes if a full syndrome of both poles exists at the same time technically in bipolar i disorder that is called a mixed episode such things likely also often happen in bipolar ii disorder but technically again the psychiatric nosology system does not for some reason identify that as a bona fide entity mixed hypomania most authorities believe that in the presence of any mania symptoms depressive symptoms worsen if antidepressants are used and mixed episodes are fundamentally thought of as variants of mania rather than depression