 [ Symptoms ] can i give my 2 year old hylands baby cough syrup and then bynadryl a few hours later for her runny nose and sneezing [ Disease ] assuming you adhere to the proper doses these two medications are compatible please be advised that children can have a paradoxical effect with benadryl in other words an antihistamine like benadryl that would make you sleepy can make a two year old hyper and more active this may not be desirable at bedtime do not forget that saline nose drops or sprays and the use of a cool mist humidifier at bedtime is also very helpful for colds