 [ Symptoms ] i am titrating down from seraquel having awful but expected side effects bp rose to unexpected 14096 is this dangerous  took seraquel dosage from 300 to nothing over about two months also discontinued wellbutrin from 150 to nothing in two weeks all this was after receiving 6 weeks tms am still taking lithium 300 mg gabapentin 300 mg trazodone 50 mg i had been taking propranolol 50 mg but missed a week is worth in error i am a 35 year old female [ Disease ] i hope you have not taken yourself off your medications without medical supervision that is dangerous and unwise no one should stop taking antipsychotic and antidepressant medications without talking it over with their psychiatrist and developing a plan to deal with any crises that arise to answer your question i do not know of any medical reason why your blood pressure would spike due to tapering off seroquel or wellbutrin however you could experience greater feelings of stress after discontinuing those medications and this could lead to an increase in blood pressure if your blood pressure reading was elevated only one time it is probably nothing to be concerned about if you are noticing it remains elevated consistently then you should make an appointment with your doctor for an evaluation generally speaking consistently elevated pressures in the 140 range do constitute hypertension high blood pressure that said 140 is considered the low end of the high blood pressure scale this does not mean it should go untreated however wishing you well