 [ Symptoms ] on antibiotics for 48 hours for fever + drainage is it ok to also take advil for a headache  48 hours ago i was prescribed antibiotics flonase and an expectorant   my fever seems to have dropped from a high of 102 0 the first night to ~ 99 98 8   99 6 today however my eyes hurt my sinuses seem inflamedsensitive to touch i would like to take advil for a headache any advice [ Disease ] sorry to hear you are going through this no fun assuming you are not allergic to ibuprofen advil and you are not taking any other non steroidal anti inflammatory agents naproxyn aspirin prescription pain relievers with nsaids in them you should be a ok to take some ibuprofen for the pain if you have any questions about this though feel free to ask your pharmacist first do not forget to take all of your antibiotics do not be that person who gets to the final two pills and decides it is too much of a hassle to finish the bottle do not do it take them all it is important feel better soon