 [ Symptoms ] what are the side effects of taking a proton pump inhibitor for a long time [ Disease ] and one that i was just asked the other day at the pharmacy long term use of proton pump inhibitors ppis appears safe and all of the studies addressing long term use have a follow up of 10 years or less there is still a need for studies that look at long term use    over 10 years if you have any questions talk to your pharmacist we are happy to help