 [ Symptoms ] can acid reflux cause sleepless nights and disruptive breathing and constant burping [ Disease ] no not really i mean it is best to take all medications on a close schedule in other words if a medication is taken once every 24 hours or daily it is a good idea to try to take it exactly every 24 hours but as nurses our guideline is you can administer a medication within a one hour window on either side of the appointed time and still be considered on schedule  that means you could take the blood pressure pill at the 23 hour mark or the 25 hour mark and still be considered on schedule  but honestly take a daily pill within a four hour window probably is not going to cause any problems i would try not to make a habit of it but if that is what works for you today you should be fine hope this helps