 [ Symptoms ] why is my anti depressantanxiety medication not working when i am on my period how do my hormones affect the drug  i am taking cymbalta for depression and anxiety and i have noticed that about a week before and during my menstrual cycle the medication seems to stop working and my mental state plummets i should mention that when i was not taking an anti depressant around my period was when i would feel most anxious and suicidal i do not have a family doctor and my psychiatrist is difficult to get ahold of i have not been able to have a physical check up in many years i am 21 [ Disease ] yes e coli can be one of the possible pathogens since this bacteria quite prevalent in the neighborhood