 [ Symptoms ] was on 150 effexor xr increased to 225  my depression is worst  sweating alot   not sleeping am i having an overdose  depression has gotten severe and sleep only 1 to 3 hours a day what should i do [ Disease ] if you suspect you have overdosed on any medication contact a poison control center or emergency room immediately us residents can call the us national poison hotline at 1 800 222 1222 canada residents can call a provincial poison control center if at the current dosage you feel this medication is not helping or you notice worsening depressionother psychiatric conditions unusual behavior changes including possible suicidal thoughtsattempts or other mentalmood changes including newworsening anxiety panic attacks trouble sleeping irritability hostileangry feelings impulsive actions severe restlessness very rapid speech contact your prescribing doctor it is especially important to watch for the above symptoms when a new antidepressant is started or when the dose is changed for more information <link> take care