 [ Symptoms ] could strong ammonia spray cleaner cause sinus infection i was using a spray cleaner i made from a mixture of ammonia & water later my sinuses were dripping and when i put my head down or lay down i smell this strong odor i have been using simply saline and it helps for a while but comes back my sinuses are not congested or puffy and i do not have a fever [ Disease ] infections are caused by germs microorganisms like viruses or bacteria ammonia does not have germs but it can cause inflammation in the nasal membranes and sinuses i suspect you are experiencing a chemical inflammation not an infection