 [ Symptoms ] my husband recently passed away what should i do with all of his leftover prescription medication [ Disease ] this is another great question medications should be disposed of in a safe and environmentally protective manner there are several steps you can take to protect children and pets from potentially harmful effects 1  pour medications into a sealable bag crush it or add water to dissolve it 2  add kitty litter sawdust or coffee grounds to the plastic bag 3  seal the plastic bag and put into trash 4  remove and destroy all personal information from medication containers prior to recycling or throwing them away there is a small number of medications the fda recommends disposal by flushing for more information about safe medication disposal please visit <link>