 [ Symptoms ] can amoxicillin 500mg be taken the same time as minocycline 100 mg i take minocycline daily for acne but recently was prescribed amoxicillin for a infected rash on my nose since minocycline is the only med that worked on my acne problem i am concerned that not taking it for 10 days or so will only make my acne return [ Disease ] you probably want to talk with your doctor about an alternative the webmd interaction checker says this serious   use alternative potential for serious interaction regular monitoring by your doctor required or alternate medication may be needed amoxicillin oral + minocycline oral minocycline oral decreases effects of amoxicillin oral by opposing drug effects <link>