 [ Symptoms ] can cold sores come back in only 1 spot all the time i get a sore on my bottom lip about twice a year its always in the exact same spot right in the center of my bottom lip it starts as a lump inside the lip and the next day it works its way from the inside of my lip to the center on the outside it takes a few weeks to get rid of it i find that if i keep it dry and do not use lip balm then it goes away faster [ Disease ] that is the nature of this herpetic beast it does come back often in the exact same spot or in close proximity this characteristic often helps clinicians make the diagnosis