 [ Symptoms ] does metformin cause low libido in men i am currently taking 500 mgm of metformin twice a day for border line diabetes type 2 in addition i take lipitor 20 gms at night plus 1 25 gms of altace ramipril  i have very low desire for sex i am 65 years old and had a triple coronary by pass about 5 years ago i am still physically active and exercise 30 mins on an elliptical 3to4 times a week are the medications i am taking the cause of low libido [ Disease ] if the hives do not clear up fairly quickly or if they are accompanied by difficulty breathing your wife should seek immediate medical attention these can be the signs of a severe allergic reaction to something    food medication etc if your wife gets hives occasionally as some people do and they are not accompanied by other symptoms then i would suggest she speak to her doctor about getting a prescription specifically for the hives there are medications other than benadryl that are used to treat hives in terms of combining antihistamines i would suggest you speak to a pharmacist while benadryl diphenhydramine has a different chemical composition than zyrtec cetirizine they still are both the same class of medication generally we try not to combine medications of the same class unless specifically directed to do so by a physician i hope that gives you some clarity