 [ Symptoms ] can my teenage daughter safely take ibuprofen and nyquil at the same time [ Disease ] there are a number of different products available in the nyquil product line and they have different active ingredients it is always important to read the label of the particular product you are interested in to verify the ingredients contained in that product nyquil may contain a pain relieverfever reducer and when it does it typically contains acetaminophen if acetaminophen is in your product it may provide adequate relief for your daughter is symptoms however not all nyquil products have a pain relieverfever reducer in them and your daughter may take ibuprofen for another reason or may find that the acetaminophen in the nyquil is not sufficient for her problem in these cases then it would then be fine to take both ibuprofen and nyquil together