 [ Symptoms ] the doctor prescribed augmentin es for my son is ear infection & cough it was left unrefrigerated at night is it safe [ Disease ] while it is best to keep augmentin refrigerated at all times to maintain efficacy i am uncertain as to whether or not the efficacy was compromised because it was left out of the refrigerator all night it does not become dangerous to use after it has been left out of the refrigerator but it may not work to cure your son is infection and could prolong his illness to be on the safe side i would suggest getting a new prescription without knowing anything else about your son is situation i would say that is the way to ensure he continues to get the most effective form of the medication