 [ Symptoms ] can nicotine replacements be dangerous if taken for and extended period of time [ Disease ] you ask an interesting question when used as directed for smoking cessation nicotine replacements such as gum and patches probably can be safely used for an indefinite period of time however it is possible to abuse nicotine replacement products by exceeding the maximum dosage in this case a person could cause himherself harm over the long run it is worth noting also that nicotine itself is kind of a bad actor  it can cause slow wound healing among many other physiological effects it can deplete the body is vitamin c stores anyone who uses tobacco products or uses nicotine replacement products should take a vitamin c supplement in my opinion wishing you well