 [ Symptoms ] i take methotrexate and humira is it safe for me to take schizandra i take methotrexate2 5mg x7per week humeria40mg every 2 weeks for ra i want to know know if it is safe to start taking scizandra fruit [ Disease ] schisandra has the potential to interact with many different medications    either increasing or decreasing the medication is effects in the body be very careful taking this with your medications and do not take it without first checking with your doctor as with many supplements we do not have enough information to know what effects it may have particularly in someone on medications like humira and methotrexate medscape com its a site for physicians has a free drug interaction checker that is really helpful here is a link <link> i hope this helps