 [ Symptoms ] are there less expensive generics for nexium for long term use [ Disease ] currently nexium does not have a generic available on the market however it belongs to the proton pump inhibitor drug class which includes several generics both prescription and over the counter strength for over the counter there are two medications available which are prilosec omeprazole and prevacid lansoprazole prescription medications that have generics available are prevacid lansoprazole and protonix pantoprazole [check with your] insurance company to see what medications in the same drug class are covered