 [ Symptoms ] can my blood pressure medication cause cold feet i have been on blood pressure meds approx 2yrs [ Disease ] artificial sweeteners including splenda sucralose are considered safe and are a good option for limiting caloric intake there is actually no evidence in humans that any artificial sweetener is dangerous to our health other sweeteners include equal aspartame and sweetn low saccharin there are also many generic alternatives stevia truvia is an herbal sugar substitute while early studies suggested a possible link between aspartame and cancer other research has refuted that and it is also considered safe