 [ Symptoms ] i take toprol xl 100 and lipitor 10 can i take advil with them [ Disease ] you are smart to ask questions about drug interactions many people do not think about how over the counter medications may affect their prescription meds so good for you in terms of toprol xl and lipitor you do not need to worry about an adverse reaction with advil ibuprofen ibuprofen is a non steroidal anti inflammatory drug nsaid it is a different class of medication than your blood pressure and cholesterol meds that said i do not know what other medications you might be taking it is possible ibuprofen would react with one of them i also know nothing about your health history i am providing general information only your best bet is to ask any pharmacist about drug interactions they are the pros in this regard if possible ask the pharmacy that fills your prescription meds they have your complete medication history and can give you very accurate information about what over the counter drugs are safe for you to take wishing you well