 [ Symptoms ] i want to take nyquil but can i take it if i am taking buproprion [ Disease ] never take paxil or prozac and nyquil as these two drugs triple the dose of nyquil in your system and can hurt your heart and you bupropion only has a mild interaction in a very very small percentage of people and is safe to mix if you are really worried take the nyquil but use one third less than the dose suggested on the nyquil bottle