 [ Symptoms ] is it safe to take diflucan during pregnancy  fluconazole diflucan at a single low dose is pregnancy class c which means risk to the developing baby cannot be ruled out [ Disease ] fluconazole diflucan at a single low dose is pregnancy class c which means risk to the developing baby cannot be ruled out in studies on animals and people when pregnant mothers took fluconazole in high doses 400 mgday for weeks or months birth defects in the newborn children and animals were sometimes seen at these doses fluconazole is considered pregnancy class d – meaning it should absolutely not be taken by a mom to be fluconazole is most often taken in a single smaller dose 150 mg once as treatment for a vaginal yeast infection there does not seem to be a significant risk to the developing baby from such a low dose of fluconazole talking with your obgyn doctor is the best way to decide if fluconazole is safe for you and your baby