 [ Symptoms ] i had my appendix removed about nine years ago i have been having pains every since [ Disease ] com most metals used in surgery are titanium which is used because it causes the least amount of allergic reactions per 100 000 patients but it is still possible to be allergic to it also many pins clips and sutures labeled and marketed as titanium actually have small impurities metals such as nickel which are more likely to cause allergic reaction