 [ Symptoms ] i am really confused what can cause my cholesterol to get that high [ Disease ] hi for a woman of your age its definitely abnormal to have such high cholesterol levels and sudden weight gain this may happen due to hormonal changes caused by endocrinal changes occuring in the body if you have a positive family history then these levels will be on high range even if you dont have positive family history u need to start on good cholesterol reducing tablets weight loss can be due to thyroid disturbances take iodine salts in large amount get a second opinion from a good endocrinologist thanks