 [ Symptoms ] is it safe to take diflucan with amoxicillin and clavulanate potassium  i am afraid to get c diff ugh  a retired nurse  i was first prescribed clindomycin which did not work i took the whole course then the doctor put me on the amoxicillin time release tabs i want to take diflucan for yeast overgrowth but do not know if it is safe [ Disease ] it is safe if you have a yeast infection and really need it difulcan is not a preventative