 [ Symptoms ] i have not had a voice for 7 weeks and a sore throat and really sore neck [ Disease ] that is a great question and i am glad you are asking it so many people do not stop to think about possible drug interactions with over the counter medications good for you your best bet is to ask your pharmacist he or she will have your entire medication profile available and can tell you if alka seltzer plus is appropriate for you if not your pharmacist can recommend something that will work for you hope this helps