 [ Symptoms ] can i take tylenol pm while taking mobic for arthritis [ Disease ] tylenol pm contains acetaminophen pain aid and diphenhydramine antihistamine mobic belongs to the nonsteroidal anti inflammatory nsaids drug class which also has pain aid properties if you are looking for a specific sleep aid more questions for assessment need to be asked in order to appropriately answer this question if you are just looking for a sleep aid only and for temporary relief then consider taking diphenydramine alone especially if mobic is controlling the pain associated with arthritis determining the cause of a sleep issue and working with your health care provider is important in selecting an appropriate aid dose and frequency of use