 [ Symptoms ] do antidepressants help arthritis pain i was on lexapro for a number of years to treat the symptoms of menopuse i recently stopped taking lexapro and am experiencing greater than average pain everyday i do have osteo arthiritis has anyone experienced this and is there anything i can take to combat the pain i am taking ibuprofen and it barely helps at all [ Disease ] talk to your doctor about prescription nsaids antideppressants are not usually the course of standard for oa