 [ Symptoms ] what kinds of medications affect sperm counts  my boyfriend is taking lisinopril metformin tramadol naproxen hydrochlorothiazide ferrous sulfate diltiazem hcl and furosemide [ Disease ] if your boyfriend is concerned about how his medications affect his sperm counts he should really talk with his health care professional lifestyle factors such as smoking using illicit drugs and being over  or under weight can all adversely affect male fertility as well