 [ Symptoms ] what are common side effects from medications used to treat headaches [ Disease ] over the years i have seen side effects from every medication we use for headaches verapamil seems to cause the least problems as side effects from this medication tend to be mild when they occur and go away quicly when you stop it most common side effect is constipation probably 5 of my patients and may 1 in 200 300 patients has puffy ankles from this i have only had 1 in every 500 1000 patients rough guess get light headache or fatigued on verapamil propranolol causes fatiguelight headedness in probably 5 10 of patients that i have tried it on and in some people can increase the chance of depression on average topamax causes tingling in the hands in 50 of patients weight loss in 20 not usually a bad thing and trouble thinking in about 2 this is at the doses used for headache prevention thanks for your reply