 [ Symptoms ] my psa and free psa have been rising but not consistently [ Disease ] endometriosis refers to the presence of uterine lining tissue living outside of the uterine cavity it can be associated with pain adhesions infertility bladder or bowel symptoms etc or none of the above one of the key words to describe endometriosis is unpredictable it may respond to one medication today and not tomorrow the treatment depends on a patients goals resources history etc  clomiphene citrate [clomid] is in the family of medications called selective estrogen receptor modulators it is a very weak estrogen in many estrogen responsive tissues that means that clomid can block or reduce the body is response to natural estrogen since natural estrogen causes the lining of the uterus to grow potent estrogens may also cause endometriosis implants to grow as well in the sense that clomid would blunt this response we would not expect clomid to make endometriosis worse if we are using it to treat a patient with infertility