 [ Symptoms ] i am taking prednisone can i take benadryl too  i have a severe case of poison ivy and have been prescribed 80mg of prednisone i am still itching at night and having trouble sleeping someone told me that taking 2 benadryl tablets 12 hour before going to bed will help me get a good nights sleep with no itching  is it safe to take them together [ Disease ] most helpful answer yes you can take antihistamines like benadryl while taking prednisone i have the same issue i asked the dermatologist and my pcp and they both said it would be safe it helped me sleep much better