 [ Symptoms ] how often should i change my sheets [ Disease ] if you are wearing pajamas changing sheets once a week is fine if you are not wearing pajamas or sleeping in the nude then you will probably want to be changing them at least twice a week a lot of people when they change their sheets they do not wash their mattress pad and so that is another thing that people do you need to have a couple of mattress pads that you can rotate in and out and change more often