 [ Symptoms ] for several weeks my right cheek has been swollen and painful with white spots on the lining is this oral cancer [ Disease ] it makes sense to take them at same time each day but it is not 100 necessary antidepressants are made to work with each tablet for example if you take it one day you are not depressed and if you miss a day you get depressed they are not onoff switches the idea is to take antidepressants every day so they build up in your system and then they start to work 4 6 weeks later as a cumulative effect over time 