 [ Symptoms ] does xanax show up in hair sample [ Disease ] only women who no longer have a uterus should consider using estrogen alone therapy et for women with a uterus the option they might consider is estrogen plus progestogen therapy ept progestogen is needed to protect the uterus and balance the effects of estrogen using et alone for 5 or more years can more than triple the risk of developing cancer of the uterus but adding progestogen prevents the uterine lining endometrium from thickening and greatly reduces the cancer risk then of course each woman must determine with her healthcare provider if ept is right for her