 [ Symptoms ] do people with schizophrenia have faulty brain chemistry [ Disease ] it is likely that an imbalance in the complex interrelated chemical reactions of the brain involving the neurotransmitters dopamine and glutamate and possibly others plays a role in schizophrenia neurotransmitters are substances that allow brain cells to communicate with one another basic knowledge about brain chemistry and its link to schizophrenia is expanding rapidly and is a promising area of research