 [ Symptoms ] what is sapho synovitis acne pustulosis hyperostosis and osteitis syndrome [ Disease ] sapho synovitis acne pustulosis hyperostosis and osteitis syndrome is a chronic disorder that involves the skin bone and joints synovitis means inflammation of the joint lining synovium typically this causes warmth tenderness pain swelling and stiffness of involved joints arthritis acne is a skin condition featuring tiny areas of inflammation with pus formation at the hair follicles acne occurs most commonly on the face and upper back pustulosis is a very inflammatory skin condition resulting in large fluid filled blister like areas pustules typically on the palms of the hands andor the soles of the feet the skin of these areas peels and flakes exfoliates hyperostosis means abnormal excessive growth of bone the hyperostosis of the sapho syndrome frequently is located at the points of the bone where tendons attach osteitis means inflammation of the bone patients with sapho syndrome can develop inflammation of the sacroiliac joints sacroiliitis as well as inflammation of the spine spondylitis which leads to stiffness and pain of the neck and back