 [ Symptoms ] how do i kinow if the pain in my calf is a blood clot  i have had pain in the center of my calf for about 48 hours it is not red or hot but the pain feels like a charlie horse that will not go away [ Disease ] for people with diabetes it is so important to check for interactions between your diabetes medications and any prescription or nonprescription medications before use ibuprofen can put a strain on your kidneys which could already be happening because of your diabetes if your doctor has prescribed ibuprofen he most likely checked your kidney function first and knows that the ibuprofen is safe for you to use while taking prescription ibuprofen it is important not to take any nonprescription nsaids such as medications that contain ibuprofen or naproxen aleve