 [ Symptoms ] does ra cause fatigue  i am extremly tired all of the time i have ra can the fatigue be caused from ra or mexotrexate [ Disease ] i do not know i do not know anything about your boyfriend is medical history or have any why of examining him but based on what you have shared he needs to see a medical provider to make sure that he does not have a treatable infection epididymitis orchitis etc  that may be causing his difficulty