 [ Symptoms ] can staph infections come back  i had fallen on my knee which swelled tremendously then blistered in a couple of spots after being admitted to the hospital i was told that i had a staph infection some of the paperwork mentions septic is that the same thing and even though i am taking 3 000 mg of antibiotics a day can the infection come back [ Disease ] staph infection can come back by simply being re exposed again or by not properly cleaning wounds some species of staph live on our skin i do not know what kind of antibiotic you are taking but i trust the choice of medication is appropriate for the type of staph that you have