 [ Symptoms ] what other medications are used for treating migraine headaches [ Disease ] narcotics and butalbital containing medications sometimes are used to treat migraine headaches however these medications are potentially addictive and are not used as initial treatment they are sometimes used for individuals whose headaches fail to respond to over the counter medications but who are not candidates for triptans either due to pregnancy or the risk of heart attack and stroke in patients with severe nausea a combination of a triptan and an antinausea medication for example prochlorperazine compazine or metoclopramide reglan may be used when nausea is severe enough that oral medications are impractical intravenous medications such as dhe 45 dihydroergotamine prochlorperazine compazine and valproate depacon are useful