 [ Symptoms ] why does ibu profen cause ankle swelling  my husband takes a lot of ibu profen for back pain and arthritis pain lately his ankles are swollen and itchy it is not pitting edema they are not discolored it has been 2 weeks he is in general good health [ Disease ] if you take ib is for a long period of time they will raise your b p if your b p get is too high and that way for a period of time it will make them swell