 [ Symptoms ] what would cause nightly chills and fever and then during the day the symptoms go away and return at night [ Disease ] if you have been out of the country recently you may need to have a tuberculin skin test tuberculosis can cause night sweats chills cough fatigue fever as well as other things or can be asymptomatic the skin test is not painful just a bit uncomfortable because they create a tiny blister under your skin and check it 48 hours later for a reaction you might be taking medication that causes these side effects best advice is to just go see your doctor to make sure you do not have any infections