 [ Symptoms ] does an amoxicillin allergy mean i can not take oxacillin  can i take oxacillin with an amoxicillin allergy even though i took penicillin throughout my childhood without any problems [ Disease ] if you are allergic to amoxicillin you should avoid all drugs in the penicillin class this would include oxacillin it is entirely possible to have taken a penicillin in childhood without any adverse reaction and then develop an allergy later in life that is because allergies develop upon repeated exposure to an allergen in other words almost no one is allergic to penicillin the first time they are exposed most people exhibit an allergic reaction on some subsequent exposure you should be sure to note your penicillin allergy on your medical record a severe allergic reaction to penicillin can result in death for most needs there are other antibiotics that can be used in place of a penicillin wishing you well