 [ Symptoms ] how long does imodium stay in your system due to the type of colon surgery i had i have chronic diarrhea sometimes i was told i could take imodium prior to going out to meet friends for the day as a cautionary measure  how long does imodium stay in your system [ Disease ] in adults imodium can be taken up to four times a day for two days for the managment of diarrhea it will likely remain in your system for at least a half day but the effects of this drug are not the same in all people some people require taking this medication after each loose bowel movement up to four times a day while others may not need such a high dose any beneficial response would likely be highly individualized if your surgeon recommended this medication for your particular condition heshe would likely be the best source for a patient specific recommendation