 [ Symptoms ] what is a good otc treatment for eczema [ Disease ] over the counter treatments for eczema include anti itch products that contain diphenydramine or hydrocortisone and moisturizing lotions such as cetaphil eucerin aquaphor and their generics for more severe cases over the counter regimens may need to be supplemented with a stronger steroid cream seek medical advice if over the counter treatments do not help to control your symptoms or your lesions become worse