 [ Symptoms ] can hydrocodone 5acetaminophen for pain be taken with ciprofloxacin antibiotic to treat infection if present  hydrocodone 5acetaminophen prescribed initially for back pain associated with enlarged prostate and ciprofloxacin prescribed for possible infection though clinically not detected [ Disease ] those medications are chemically compatible to be taken at the same time assuming you currently have clinical indications to take both it is never a good idea to self prescribe an antibiotic left over from a previous infection