 [ Symptoms ] can i take midol while taking naproxen and amoxicillin [ Disease ] i would suggest discontinuing the naproxen temporarily if you choose to take midol naproxen belongs to a class of drugs called nonsteroidal anti inflammatory drugs nsaids midol is a combination drug some of its preparations also contain an nsaid in fact midol extended relief contains naproxyn in general it is not a good idea to combine drugs within the same class for example taking two different types of nsaids such as aspirin and ibuprofen is not usually a good idea since midol and naproxyn both contain nsaids i would not recommend taking both i hope this helps