 [ Symptoms ] what is the most effective way of removing blackheads from the nose and t zone and keeping them away [ Disease ] the best way to remove blackheads is to have a dermatologist do it they use a small instrument called a comedone extractor also retin a and differin are two potent anti blackhead comedolytic prescriptions available discs with glycolic and salicylic acid are also helpful in preventing comedones a k a blackheads from forming