 [ Symptoms ] going on a long flight with a cold need to sleep sudafed with xanax or sudafed with nyquil  i have a cold and i am going on a very long flight i need to sleep would i be better off taking sudafed with xanax or sudafed with nyquil [ Disease ] absolutely no sudafed sudafed is a stimulant like coffee the xanax is fine if prescribed for you but avoid coffee tea and that sudafed if you want to sleep hopefully the flight will be smooth and your seat mates quiet respectful and non snoring