 [ Symptoms ] is it safe to take ibuprofen with vicodin or is tylenol safer [ Disease ] please do not take tylenol  acetaminophen  with vicodin hydrocodone apap because vicodin contains tylenol already it is very easy to exceed the maximum daily limit of acetaminophen by combining these two drugs and high doses of acetaminophen may lead to liver damage if the hydrocodone is not controlling your pain i would suggest you speak with your health care provider from a pharmacology standpoint there is no harm in combining ibuprofen with hydrocodone but ibuprofen is a blood thinner so if you are taking hydrocodone to control post surgical pain for example your doctor may not want you taking a blood thinner like ibuprofen also your health care provider may not want you taking ibuprofen based on other medications you currently take your past medical history and many other factors so in a nutshell i would suggest you simply put a call in to your provider for guidance on what medications are safe for you to take for pain control wishing you all the best