 [ Symptoms ] does naproxen affect blood pressure my blood pressure is usually in the 12572 range but lately it has risen by 20 points for both numbers i started taking naproxen a couple of months ago in place of aspirin it worked better for my mild arthritis my weight diet exercise schedule have not changed in the last 6 months but for some reason my blood pressure has risen i am 70 yo and in good health is naproxen the reason  thanks [ Disease ] it looks like it can and there is even a webmd article about it good catch medications that cause high blood pressure non steroidal anti inflammatory drugs nsaids nsaids include both prescription and over the counter medication they are often used to relieve pain or reduce inflammation from conditions such as arthritis however nsaids can make your body retain fluid and decrease the function of your kidneys this may cause your blood pressure to rise even higher putting greater stress on your heart and kidneys nsaids can also raise your risk for heart attack or stroke especially in higher doses common nsaids that can raise blood pressure include ibuprofen  advil motrin  naproxen  aleve naprosyn  here is the whole article <link>