 [ Symptoms ] can prozac prescribed for post natal depression cause weight gain only in the stomach region  i take 40 mg of prozac once a day i also have the mirena iud no other medication but over xmas i took a pregnancy test negative because my tummy is looking so pronounced it seemed a bit far fetched but it was very noticeable i got my period the next day now i have tender breasts but no other symptoms of pregnancy i had very bad nausea and migraines with my first 2 children my tummy is still massive i usually weigh 112 lbs i am weighing closer to 120 lbs any ideas thanks [ Disease ] absolutely changes in appetite and weight is a common side effect for prozac and many other antidepressants and may very well be the cause of your gaining weight