 [ Symptoms ] how long does it take for a methylprednisolone injection to take effect i got it 30 hours ago for an ear infection they have an cortisporin ear drop waiting for me at the pharmacy should i pick it up now or give the infection more time to work [ Disease ] maybe not alarmed but concerned any time that you have a mole that is changing gotten darker bigger uglier or whatever it would be in your best interest to see a dermatologist the concern of course would be that a benign mole has become more suspicious of a skin cancer often the only way that a dermatologist can be sure is to biopsy or remove it many moles make innocent benign changes but unfortunately so do become malignant rather than be alarmed or lose any sleep see a specialist or your primary care medical provider to be sure