 [ Symptoms ] why do over the counter migraine medicine make my face swell i used the kroger brand migraine medicine and it made my face swell i have not had a problem with any other headache medicine i was just wondering what could cause this [ Disease ] possibly a allergic reaction or maybe a med interference i have never been able to get any over the counter migraine meds to work besides excederine tension and i was put on fioricet which helped i would say a different ingredient whether inactive or active is in the off brand nothing really compares to the original