 [ Symptoms ] ear canal itch and red for a month allergic reaction of neomycin polymyxin drops continuation  i was diagnosed with otitis externa on my right ear and was prescribed with neomycin polymixin after 2 doses my other ear feels strange and the doctor not ent told me to apply the drops next day i got severe itch all over my body and stopped the drops  i went to several ent used many topical and oral antibiotics but the infection has not cleared up one month there is severe itch and redness is it possible that the neo poly drops caused a skin rash in that case no antibiotics would work [ Disease ] an allergic reaction to neomycin is actually quite common i see this on occasion with neomycin containing eardrops your doctor needs to prescribe something else for you as well as treat the allergic response one more consideration since you have had this problem for a month is that the cause may not be bacterial you could easily have a fungal infection in your ear canal requiring an entirely different treatment