 [ Symptoms ] is diphenhydramine hci safe in pregnancy  i m 9 weeks pregnant i have nasal congestion i do not have a cough i have tried sudafed benedryl and tylenol cold after a week nothing is working i am unable to breathe through my nose which makes sleeping almost impossible i would like to try mucinex [ Disease ] ask you ob about mucinex since there are many types and combinations diphenhydramine is the generic name for benadryl your ob can provide you will a list of safe medications you can take during your pregnancy antihistamines like diphenhydraminebenadryl will not open up a stuffy nose they are used to dry a drippy nose try nasal saline sprays and a humidifier colds are not the only thing that can cause a stuffy nose when you are pregnant those raging hormones can also cause cold like stuffiness