 [ Symptoms ] hemorrhoids after the cream was applied it went away but it has stopped working and this lump has become really hard doctor has prescribe this cream and in the past it had been working shrinking away or swollen has disappeared but in feb this occur again for him and he is been using this cream since but it has not shrink at all instead it became really hard lump whats the cause of the hardness and what should i do for my dad [ Disease ] this is a really good question and actually they can take methylprednisolone on an empty stomach or while they are fasting it is okay sometimes we recommend it to be taken with food because people complain of abdominal pain or an upset stomach with it and it is okay to take with the other two medications if they are using to help with their breathing as it might work with copd chronic obstructive pulmonary disease if you ever have any questions like this though whether or not you can take something with or without food or other opportunities where you may not be sure about it come and talk to the pharmacist ask us we will be more than happy to help you we are the medication experts