 [ Symptoms ] what are the symptoms of crohn is disease [ Disease ] there are many things that can cause swelling below the knee known as edema it is usually a result of fluid retention and can be caused by several different health conditions cyclosporine has been associated with causing edema in less than 2 of the people that take it i suggest you contact the prescriber and notify himher of your father is swelling they can tell you how best to handle it considering his past medical history