 [ Symptoms ] i have a fib and the dr recommends an ablasion does medicare cover this procedure [ Disease ] several medications may help fight knee pain and in some cases the inflammation that can cause joint swelling and discomfort they include acetaminophen tylenol this is the first medication to try as a knee oa osteoarthritis treatment say arthritis specialists that is because it is relatively safe compared to other pain relievers although too much can cause liver damage acetaminophen does not lessen inflammation nonsteroidal anti inflammatory drugs nsaids these can help relieve pain and fight inflammation that may be adding to your pain there are prescription nsaids your doctor can prescribe available over the counter ibuprofen advil motrin ib ketoprofen orudis kt and naproxen aleve are among your other options for pain relief other analgesics when other pain relievers fail to control pain your doctor may prescribe stronger analgesics these include tramadol ultram and acetaminophen with codeine tylenol with codeine