 [ Symptoms ] can caffeine cause a false positive on a drug test  a client of mine tested positive today for amphetamines using a 10 panel urine dip test is it possible he had a false positive he claims to take tylenol with caffeine for migraines every morning [ Disease ] a positive test for amphetamines will not be falsely influenced by caffeine or acetaminophen there is another reason most likely that your client took an amphetamine or a medications containing a similar drug but it is not this one