 [ Symptoms ] what can you expect if you use lamictal to treat bipolar disorder [ Disease ] the formal research studies conducted by its manufacturer glaxosmithkline showed that a it had no value in acute mania b it had some modest value in bipolar depression especially if more severe but not treatment resistant c it prevented depressions and manias but did a better job preventing depressions than manias d it worked better in bipolar i than bipolar ii and e it had no clear benefit for anxiety symptoms apart from the risk of rash related to rapid dosing it also appears to have few side effects and is weight neutral