 [ Symptoms ] no period after using depo should i be concerned  got my first depo shot on november 2 2011 my last shot was july 1st or 3rd 2012 and i bled that whole time i was on the shot and after i stopped getting the shot i have not had a period since [ Disease ] no not at all your doctor should have told you this is the main side effect i didnt have one for 10 years unless i missed my shot or had a spot here and there