 [ Symptoms ] my grandaughter appears to be missing a vaginal orifice is this a known condition  her pediatrician ordered a cream to be applied to the area when she was 3 yrs old but she would not tolerate it [ Disease ] these are most likely labial adhesions the cream is estrogen and will really help if you use it you only need to gently put a tiny amount on the area a few times a week in about a month all should appear normal again she will tolerate it if it is done gently this is a very sensitive area