 [ Symptoms ] can you take ibuprofen & mucinex fast max which contains acetaminophen at the same time [ Disease ] assuming you are not allergic to any of the ingredients in these medications the combination should be fine it is ok to mix ibuprofen acetaminophen and guaifenesin mucinex because they are in different drug classes you are wise to ask this question because you should never take products that cause you to double up on medications like acetaminophen and ibuprofen acetaminophen overdose can happen fairly quickly and have very negative effects on the liver too much ibuprofen can cause internal bleeding so good for you always read the label of over the counter medications and if you have questions about what you can and can not combine ask the pharmacist wishing you well