 [ Symptoms ] could vericose veins cause me to wake with an intense burning sensation in that area it seems every night i am awakened by a burning sensation in my leg i have what appear to be vericose veins in the same location [ Disease ] women are at greatest risk for depression around puberty post partum and around menopause statistically  these are times when estrogen levels falter i think serotonin and neurotrophic factors brain growth and health chemicals also falter this likely conveys some risk for depression let is face it these times are also stressful for women which raises depression risk given the recurrence of your depression i would suggest that whatever med you take next that resolves your depression stick with it much much longer to hopefully prevent future depressions