 [ Symptoms ] taking monocycline50mg twice a day and terbinafine250mg twice a day do they interact with each other  im taking minocycle 50mg twice a day for my acne and the terbinafine 250mg twice a day for toe fungus do they interact is it okay with taking these two medicines [ Disease ] you are smart to think about potential drug interactions whenever you have questions about prescription medications you can check with a pharmacist pharmacists represent a great resource for all types of drug related questions including potential interactions in fact it is a good idea to get all of your prescriptions filled at the same pharmacy that way the pharmacist is more likely to catch potential drug interactions before you even receive the pills i am not a pharmacist myself but i do not believe there is any interaction between minocycline and terbinafine oral one is an antibiotic and the other an antifungal generally i believe these two drug classes play nice together however you should ask your healthcare provider if your provider knew you were taking minocycline he or she would not prescribe terbinafine unless it was safe to do so wishing you well