 [ Symptoms ] can you take tylenol and benedryl together  i am taking tylenol for my sprained ankle and benadryl for night allergies i get allergy shots so my allergies have recently gotten worse [ Disease ] yes they can be taken together there are much better medications for allergies than benadryl which only lasts 4 hours why not try genertic claritin zyrtec or allegra they can last a whole day