 [ Symptoms ] how long does it take for a methylprednisolone injection to take effect i got it 30 hours ago for an ear infection they have an cortisporin ear drop waiting for me at the pharmacy should i pick it up now or give the infection more time to work [ Disease ] hello dr i think i need to give you a little more information 9 days ago i went to the er at 3am because of pain in my ear they said i had a middle ear infection and prescribed me augmentin that did not work so well so i went to my doctor yesterday morning and she gave me the injection and said that i had a middle and inner ear infection she called the eardrops into the pharmacy in case the injection didnt work she also gave me a nasal spray nasacort and zyrtec i am just wondering how long i should wait for this injection to work before i go grab these drops