 [ Symptoms ] im on blood thinner what can i take for a headache [ Disease ] most helpful answer that is an excellent question and i am glad you asked first of all it is important to realize experiencing a severe headache while taking a blood thinner can be a sign of a medical emergency especially if it is accompanied by sudden weakness dizziness confusion or the inability to speak clearly in that case you should call 911 as you probably know all the over the counter headache remedies called non steroidal anti inflammatory drugs nsaids have blood thinning properties therefore it may not be a good idea to combine them with a prescription anticoagulant blood thinner nsaids include aspirin ibuprofen and naproxyn read the label of any brand name medication to see if it contains any of these so what does that leave you with acetaminophen tylenol is the primary over the counter pain reliever that does not contain an nsaid assuming you are not allergic to it you can try taking plain acetaminophen to see if that helps your headache your best bet is to call your medical provider to find out what he or she recommends for a simple headache when you are taking a blood thinner wishing you all the best