 [ Symptoms ] i had swelling in feet ankles and legs low hemoglobin now swelling again [ Disease ] most helpful answer has your brother seen a medical professional for the symptoms you describe he obviously was diagnosed with an enlarged spleen and fatty liver disease but has he been seen for the vomiting and weight loss if your brother vomits up everything he eats or drinks he is at serious risk for dehydration you should not allow vomiting to go unchecked for any period of time unfortunately a forum like this is not a place to receive a diagnosis it is impossible to tell what is going on with your brother without doing a physical examination and possibly some lab tests could the vomiting burping loss of appetite and weight loss be related to the enlarged spleen probably not could they be related to the liver problems maybe or they could indicate some other illness or disease entirely your brother needs to see a doctor to find out for sure any time a person is experiencing symptoms like unexplained weight loss we get a little concerned it could be something minor or it could be something serious there is no way to tell without a physical exam wishing you well these all symptoms may be due to liver disease for the clarification of spleen involvement get his blood tested for complete blood count you need to see an expert who may examine your brother and provide proper diagnosis