 [ Symptoms ] can i mix vicodin with fioricet [ Disease ] let is look at the ingredients of each of these medications separately vicodin contains hydrocodone and acetaminophen fioricet contains acetaminophen butalbital and caffeine i would be cautious in using both products in order to prevent overdosing of acetaminophen this medication while safe as an over the counter medication can cause damage to the liver at extreme doses if you need to take both medications consult your local pharmacist to discuss the correct dose for you