 [ Symptoms ] will there be any adverse interactions between accutane 40mgday and the workout supplement creatine 5gday  im a 22 year old athletic male [ Disease ] probably not but please ask your dermatologist    someone who uses accutane on a regular basis for patients over the counter supplements like creatine were not likely tested against prescription medications like accutane so there is little or no data about interactions creatine does not really do that much as far as muscle building your exercise regime is the most critical element not your supplements