 [ Symptoms ] if caught early can i take steps to prevent bedbugs from multiplying [ Disease ] there is a moderate interaction between skelaxin and geodon the drugs can depress the central nervous system and respiratory system especially in elderly or debilitated patients if your health care professionalprescriber feels that it is all right to take this combination you should be monitored carefully you should avoid hazardous activities requiring mental alertness and coordination until you know how these drugs will affect you the same interaction can be seen between skelaxin and unisom it is not advisable to take this combination if you are experiencing issues with sleep consult your health care professional to determine the root cause