 [ Symptoms ] how long does it take medication to enter your blood stream how does it take a oxycodone 30 to enter your blood stream [ Disease ] the general answer to your question is it depends on the medication every drug works differently i think what you are referring to is the peak concentration point sometimes called the point of peak effectiveness  that is the point in time at which a medication is most concentrated in your bloodstream in the case of oxycodone the medication is released almost immediately after you take it it reaches peak effectiveness within a couple of hours and then gradually tapers off over the course of about 24 hours always follow the dosing instructions on any bottle of narcotics like oxycodone if you take too much oxycodone you can stop breathing obviously that is bad if you have any questions about your prescription medications you can always call a pharmacist many pharmacies are open 24 hours a day and a pharmacist will be happy to answer any questions you have about how to take your medications hope this helps