 [ Symptoms ] what can cause blood and pus drainage from an adult is belly button for weeks even after heavy duty antibotics [ Disease ] this could be from an infection in the belly button like an ear infection or of more concern it could be from a deeper infection such as from a cyst or residual tract leftover from when you were in your mother is uterus called a urachal cyst or remnant of the urachus you need to see a general surgeon on rare occasions and this is very rare there can even be a cancer in the tract you may need a ct scan to get this looked at