 [ Symptoms ] i am having daily diarrhea for almost 3 weeks now after eating at jack in the box is it time to see a doctor [ Disease ] sure you can quit taking premarin estrogen replacement if you would like be prepared for a potential onslaught of menopause symptoms if you do so among the symptoms you might experience if you stop taking estrogen are hot flashes sometimes called hot flushes irritability vaginal dryness night sweats i do not list those to try to sway you against going off the estrogen i only list them so you do not get caught off guard i would recommend talking to your doctor about ways to taper off the estrogen gradually in order to minimize possible side effects your doctor also will be a valuable source of information regarding both the benefits and the risks of hormone replacement therapy hrt  for you given your unique medical history best wishes to you