 [ Symptoms ] i take bupropion and i want to take nyquil for my cold is that safe [ Disease ] you can take nyquil occasionally for a cold while taking bupropion there are no dangerous drug interactions between the two medications i am answering based off of research i just did on drug interactions because of my own after effects nyquil inhibits the liver enzyme that breaks down dextromethorphan which means that this cough suppressant stays in your system for a long period of time personally i am finding it unpleasant and consider myself illegal to drive if nyquil as no effect on your sleepiness or balance you may be ok i am basically dizzy for a prolonged period bah i even proof read and missed it *bupropion* inhibits the enzyme that breaks down the cough suppressant only correction needed on my above statement