 [ Symptoms ] i have been receiving testtoserone injections due to low testosterone can they cause nodules lumpiness inside penis [ Disease ] testosterone can cause pain at the injection site and other symptoms but it is not injected into the penis peyronie is disease is a condition that leads to deformities of the shaft of the penis a curved penis or lumpsnodules along the shaft is often what is seen on exam and so you may want to see your urologist it is more common that you think men who do not engage in sex may not realize that the deformitieslumps exist since this is often not seen in a flaccid penis in some men this condition can cause pain difficulty with sex and erectile dysfunction while genetics and trauma have some association to peyronie is disease the exact cause of this condition is not known there are medications to treat the symptoms associated with the condition these include medications or surgery in severe cases