 [ Symptoms ] can i cut bupropion 150mg in half [ Disease ] i guess the answer to your question is it depends on how much you are supposed to be taking you should always take prescription medications exactly as prescribed if you were prescribed bupropion 150mg daily then that is the dose you should take if you are experiencing side effects or want to decrease the dosage for some other reason you should consult your healthcare provider bupropion has two main uses as an antidepressant and as an aid to quit smoking it is almost always a bad idea to abruptly stop taking or reduce the dosage of an antidepressant medication stopping bupropion is best done under the care of a physician or other healthcare professional wishing you well