 [ Symptoms ] can a herpes blister refill after youve popped it  i messed with what seemed like an inflamed fordyce spot if it was a herpes blister would it reform a closed bump or would it simply turn into a lesion as if it popped on its own [ Disease ] yes a herpetic blister vesicle can re fill with fluid do not pop them scratch them or otherwise mess with a herpetic lesion they will dry up in their own time on their own without your help are you sure this is a herpetic lesion many vesicles can mimic herpes