 [ Symptoms ] will polycystic kidney disease cause a drug test to test positive for codeine  i am a veteran who just tested positive in drug screen for codeine i have only taken my medication that follows 1 oxycontin   1 pill 10 mg 3xday 2 roxicodone   2 pills 5 mg 4xday 3 dextroamphetamine   2 pills 15 mg 1day 4 alprazolam   1 pill 5 mg less than 15month  if pkd can not what could have [ Disease ] you are on plenty of narcotic and controlled medications but polycystic kidney disease will not cause a positive test for codeine unfortunately i do not know anything about you or your medical history to help you determine why you tested positive