 [ Symptoms ] what can i do if my prenatal vitamin makes me nauseous [ Disease ] there is a drug interaction between gabapentin and hydrocodone in which when taken together the bioavailability of hydrocodone is reduced by as much as 22 but the bioavailability of gabapentin is increased by as much as15 to avoid this interaction since you already seem to be having side effects from the gabapentin you should take the hydrocodone at least an hour before you take the gabapentin this will allow you the pain killing effects while avoiding a major interaction i am not a nurse but the other answer from the nurse was incorrect in this case when in doubt try several drug interaction checkers they are all over the web cheers