 [ Symptoms ] can a methylprednisolone injection in the spine cause muscle spasms  i had an steroid methylprednisolone injection in the sacroiliac joint 3 days ago and am now having severe muscle spasms at night mostly in the legs but in my fingers as well does this steroid have anything to do with the spasms [ Disease ] in my opinion you are experiencing signs of panic attack did you experience any sever stress lately or are you afraid of an incoming situation like exam mat be in my opinion it physcological you need to see a psychiatric doctorgood luck