 [ Symptoms ] suffering from anxiety restlessness and taking clonazepam & mirtazapine i had depression & panic attacks for the last 7 years need a second opinion [ Disease ] depression anxiety restlessness and panic attacks are best respond to a combination of a selective serotonin reuptake inhibitors ssris and benzodiazepines mirtazapine is not the most efficient ant depressant and it is not a true ssri as fluoxetine paroxetine citalopram and sertraline are i recommend 20 to 40mg of paroxetine slowly titrated up from 10mg and 1mg of either clonazepam or ativan lorazepam every 8 hours as needed for anxiety glaucoma precludes use of any anticholinergics such as hydroxyzine or benadryl diphenhydramine ssris are also at times likely to make glaucoma worse but a preliminary trial is always worth it revert back to a psychiatrist online for further help   > <link>