 [ Symptoms ] my grandaughter appears to be missing a vaginal orifice is this a known condition  her pediatrician ordered a cream to be applied to the area when she was 3 yrs old but she would not tolerate it [ Disease ] hi hypothyroidism is very dangerous on your baby so your doctor should make sure to follow the guidlines which are first trimester tsh 0 1 – 2 5 miul second trimester tsh 0 2 – 3 0 miul third trimester tsh 0 3 – 3 0 miul he should make sure to control tsh if your gynecologist does not know the guidelines then tell him or switch him good luck