 [ Symptoms ] is there a risk of liver damage if i take acetaminophen with my prescription pain medicine oxycodone  i have suffered for many years with low back pain in the past two years i have had to start taking prescription pain relievers currently i am taking roxycodone 15mg on as needed basis my dr said i could take over the counter pain relievers with the roxys if i was still experiencing pain i know there is a risk of liver damage more so with one than the other acetaminophen or ibuprofen so which is the best for me to take with my prescription pain meds thank you [ Disease ] due to the fact that my dr had me on 10650 hydrocodoneacetaminophen 8 x day for a few years my liver test were extreamly high he even called me personally and asked if i was alive not funny at the time he switched me to 10mg oxycodone and no acetaminophen what so ever ibuprofen is all i am allowed though my case may be rare i do not recommend acetaminophen to be taken daily ever be sure you know the warning signs as i was vomiting alot and very tired all the time for no reason