 [ Symptoms ] my frenulum tore so i decided to cut it off [ Disease ] you are wise to ask this question whenever someone is taking a pain reliever especially a narcotic it is good to consider whether or not an over the counter medication may interact with it i can not tell if you are referring to oxycodone or oxycontin but either way unisom should not interact with it the main ingredient in unisom that makes you sleep is a big whopping antihistamine it is not benadryl diphenhydramine but a relative of that however different over the counter sleep aids may contain a different active ingredient from unisom your best bet is to ask the pharmacist which sleep aid you can safely take with your pain reliever wishing you well