 [ Symptoms ] what are the long term effects of estrogen overdose in a dog  my dog was on synthetic estrogen for about 5 years i used over the counter estroven for humans 12 pill daily my 1st vet was ok with it she is been off the estrogen for 2 yrs we have seen 3 more vets since issues are she is bald except for her head and her rear joints are deteriorating fast she is 9 yrs old no success in help for baldness or joint issues could long term od of estroven be the cause [ Disease ] it is possible that the estroven may not have had the protective effects that the vet intended there is not any real estrogen in it just plant estrogens and a lot different herbs to calm menopause symptoms that could be part of a cause of the issues here is a great article on exactly what is in estroven <link>