 [ Symptoms ] can you get metal poisoning from a knee replacement  i had a knee replacement in 2005 i then had extensive blood work that showed a nickel allergy that was off the chart my surgeon then did my second knee replacement without using nickel in the joint i have never had relief in either knee now i have all the symptoms of metal poisoning could that be what is wrong with me if that could be it what would the treatment be thanks [ Disease ] knee and hip replacements consisting of metal on metal may cause a condition called metallosis this side effect happens when rubbing of the metal implanted surfaces results in chromium and cobalt particles accumulating in the blood stream to toxic levels some cobalt & chromium is normally found in the blood stream to carry out routine cellular actions the recommended treatment for metallosis is a complete surgical revision removing the implant and installing a new implant of the knee or hip