passages: 3230
passages: document
passages: The effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement in patients undergoing laparatomy . OBJECTIVES To evaluate and compare the effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement , adverse effects , patients ' satisfaction , mobilization , time to first defecation and time to discharge in patients undergoing laparotomy . METHODS Eighty patients ( 18 to 65 years of age ) undergoing elective laparotomy were randomly divided into four groups ( n=20 in each group ) : group C , placebo capsules and normal saline infusion perioperatively ( control ) ; group L , placebo capsules and lidocaine 1 mg⁄kg intravenous bolus dose followed by 2 mg⁄kg⁄h infusion until skin closure ; group P , 150 mg oral pregabalin and normal saline infusion perioperatively ; and group PL , 150 & nbsp ; mg oral pregabalin and lidocaine 2 mg⁄kg⁄h infusion until skin closure . Hemodynamic parameters , visual analogue scale ( VAS ) scores , analgesic consumption , side effects , time to mobilization , time to first defecation , time to discharge and patients ' satisfaction were recorded . RESULTS VAS scores of group L , group P and group PL were lower than group C ( P < 0.05 ) . Morphine consumption of group P and group PL was lower than group C ( P < 0.05 ) . Incidence of nausea in group C was higher than group L and group PL . Time to first defecation and mobilization were shorter in group L and group PL compared with group C ( P < 0.05 ) . CONCLUSION Preoperative oral pregabalin and perioperative intravenous lidocaine infusion decreased postoperative VAS scores . Preoperative oral pregabalin decreased morphine requirement and perioperative intravenous lidocaine infusion hastened gastrointestinal motility and mobilization , and decreased the incidence of nausea in patients undergoing laparotomy . Therefore , preoperative pregabalin with or without lidocaine provides superior pain relief in patients undergoing laparatomy .
entities: 3231
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3232
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3233
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3234
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3235
entities: Intervention_Control
entities: placebo
entities: 3236
entities: Intervention_Control
entities: normal saline infusion
entities: 3237
entities: Intervention_Control
entities: placebo
entities: 3238
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3239
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3240
entities: Intervention_Control
entities: normal saline infusion
entities: 3241
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3242
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3243
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3244
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3245
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3246
entities: Intervention_Pharmacological
entities: lidocaine
entities: 3247
entities: Intervention_Pharmacological
entities: pregabalin
entities: 3248
entities: Outcome_Other
entities: postoperative morphine requirement
entities: 3249
entities: Outcome_Other
entities: postoperative morphine requirement
entities: 3250
entities: Outcome_Adverse-effects
entities: adverse effects
entities: 3251
entities: Outcome_Other
entities: patients ' satisfaction
entities: 3252
entities: Outcome_Physical
entities: mobilization
entities: 3253
entities: Outcome_Physical
entities: time to first defecation
entities: 3254
entities: Outcome_Other
entities: time to discharge
entities: 3255
entities: Outcome_Other
entities: Morphine consumption
entities: 3256
entities: Outcome_Physical
entities: Time to first defecation
entities: 3257
entities: Outcome_Physical
entities: mobilization
entities: 3258
entities: Outcome_Other
entities: morphine requirement
entities: 3259
entities: Participant_Condition
entities: patients undergoing laparatomy .
entities: 3260
entities: Participant_Sample-size
entities: Eighty
entities: 3261
entities: Participant_Age
entities: 18 to 65 years of age
entities: 3262
entities: Participant_Condition
entities: undergoing elective laparotomy