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passages: document
passages: Psychological mediators of bupropion sustained-release treatment for smoking cessation . AIM The study aimed to test simultaneously our understanding of the effects of bupropion sustained-release ( SR ) treatment on putative mediators and our understanding of determinants of post-quit abstinence , including withdrawal distress , cigarette craving , positive affect and subjective reactions to cigarettes smoked during a lapse . The specificity of bupropion SR effects was also tested in exploratory analyses . DESIGN Data from a randomized , placebo-controlled clinical trial of bupropion SR were submitted to mediation analyses . SETTING Center for Tobacco Research and Intervention , Madison , WI , USA . PARTICIPANTS A total of 403 adult , daily smokers without contraindications to bupropion SR use . INTERVENTION Participants were assigned randomly to receive a 9-week course of bupropion SR or placebo pill and to receive eight brief individual counseling sessions or no counseling . MEASUREMENTS Ecological momentary assessment ratings of smoking behavior and putative mediators were collected pre- and post-quit . FINDINGS Results of structural equation and hierarchical linear models did not support the hypothesis that bupropion SR treatment improves short-term abstinence by reducing withdrawal distress or affecting the subjective effects of a lapse cigarette , but provided partial support for mediation by cigarette craving reduction and enhanced positive affect . Bupropion SR effects on point-prevalence abstinence at 1 month post-quit were also mediated partially by enhanced motivation to quit and self-efficacy . CONCLUSIONS Results provided some support for models of bupropion SR treatment and relapse and suggested that motivational processes may partially account for bupropion SR efficacy .
entities: 1425
entities: Intervention_Pharmacological
entities: bupropion sustained-release
entities: 1426
entities: Intervention_Pharmacological
entities: bupropion sustained-release ( SR )
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entities: Intervention_Pharmacological
entities: bupropion SR
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entities: Intervention_Pharmacological
entities: bupropion SR
entities: 1429
entities: Intervention_Pharmacological
entities: bupropion SR
entities: 1430
entities: Intervention_Pharmacological
entities: bupropion SR
entities: 1431
entities: Intervention_Control
entities: placebo
entities: 1432
entities: Intervention_Pharmacological
entities: Bupropion SR
entities: 1433
entities: Intervention_Pharmacological
entities: bupropion SR
entities: 1434
entities: Outcome_Mental
entities: Ecological momentary assessment ratings of smoking behavior and putative mediators
entities: 1435
entities: Outcome_Mental
entities: short-term abstinence
entities: 1436
entities: Outcome_Mental
entities: cigarette craving reduction
entities: 1437
entities: Outcome_Mental
entities: positive affect .
entities: 1438
entities: Outcome_Mental
entities: abstinence
entities: 1439
entities: Participant_Condition
entities: Madison , WI , USA
entities: 1440
entities: Participant_Sample-size
entities: 403
entities: 1441
entities: Participant_Condition
entities: adult , daily smokers without contraindications to bupropion SR use