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passages: document
passages: Randomised trial of text messaging on adherence to cardiovascular preventive treatment ( INTERACT trial ) . BACKGROUND About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed . We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment . METHODS 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages ( Text group , 151 ) or not being sent them ( No text group , 152 ) . Texts were sent daily for 2 weeks , alternate days for 2 weeks and weekly thereafter for 22 weeks ( 6 months overall ) , using an automated computer programme . Patients were asked to respond on whether they had taken their medication , whether the text reminded them to do so if they had forgotten , and if they had not taken their medication to determine if there was a reason for not doing so . At 6 months , use of medication was assessed . RESULTS Two patients were lost to follow-up , providing data on 301 for analysis . In the No text group 38/151 ( 25 % ) took less than 80 % of the prescribed regimen ( ie . stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up ) compared to 14/150 patients ( 9 % ) in the Text group - an improvement in adherence affecting 16 per 100 patients ( 95 % CI 7 to 24 ) , p < 0.001 . The texts reminded 98/151 patients ( 65 % ) to take medication on at least one occasion and lead to 20/151 ( 13 % ) who stopped taking medication because of concern over efficacy or side-effects , resuming treatment . CONCLUSIONS In patients taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease , text messaging improved medication adherence compared with no text messaging . TRIAL REGISTRATION Controlled-Trials.com ISRCTN74757601 .
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entities: Intervention_Educational
entities: text messaging
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entities: Intervention_Educational
entities: text messages ( Text
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entities: Intervention_Control
entities: not being sent them
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entities: Intervention_Educational
entities: Text
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entities: Intervention_Educational
entities: text messaging
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entities: Intervention_Control
entities: no text messaging .
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entities: Outcome_Mental
entities: adherence
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entities: Outcome_Mental
entities: adherence
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entities: Outcome_Mental
entities: adherence
entities: 3114
entities: Outcome_Mental
entities: medication adherence
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entities: Participant_Sample-size
entities: 303
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entities: Participant_Condition
entities: patients taking blood pressure and/or lipid-lowering medications
entities: 3117
entities: Participant_Condition
entities: taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease