passages: 1024
passages: document
passages: Interventions in the initial prodromal states of psychosis in Germany : concept and recruitment . BACKGROUND The Early Detection and Intervention Programme of the German Research Network on Schizophrenia ( GRNS ) investigates the initial prodromal phase of psychosis in a multidimensional approach . Two intervention strategies are being studied by two large-scale multicentre projects . AIMS To present the concept of the intervention studies , and to provide an interim report of the recruitment procedure . METHOD Comprehensive cognitive-behavioural therapy has been developed for patients in the " early initial prodromal state " . For patients in the " late initial prodromal state " the atypical neuroleptic amisulpride is explored . Both interventions are evaluated in randomised controlled trials using clinical management as the control condition . RESULTS Between January 2001 and March 2003 , 1212 individuals seeking help for mental health problems were screened for putative prodromal symptoms at four university centres . More than 388 individuals fulfilled criteria for both interventions and 188 ( 48.5 % ) gave informed consent to participate in the trials . CONCLUSIONS The screening procedure appears to be feasible and trial participation seems to be acceptable to a relevant proportion of people at increased risk of developing psychosis .
entities: 1025
entities: Intervention_Educational
entities: Comprehensive cognitive-behavioural therapy
entities: 1026
entities: Intervention_Pharmacological
entities: atypical neuroleptic amisulpride
entities: 1027
entities: Participant_Condition
entities: initial prodromal states of psychosis
entities: 1028
entities: Participant_Condition
entities: Germany
entities: 1029
entities: Participant_Condition
entities: " early initial prodromal state "
entities: 1030
entities: Participant_Condition
entities: " late initial prodromal state "
entities: 1031
entities: Participant_Sample-size
entities: 1212
entities: 1032
entities: Participant_Condition
entities: individuals seeking help for mental health problems
entities: 1033
entities: Participant_Sample-size
entities: More than 388 individuals fulfilled criteria for both interventions and 188 ( 48.5 % ) gave informed consent to participate in the trials .