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passages: document
passages: Atomoxetine in autism spectrum disorder : no effects on social functioning ; some beneficial effects on stereotyped behaviors , inappropriate speech , and fear of change . UNLABELLED Abstract Objective : The objective of this study was to investigate the short-term treatment effects of atomoxetine on autism spectrum disorder ( ASD ) symptoms in children and adolescents with both ASD and attention-deficit/hyperactivity disorder ( ADHD ) . METHODS A total of 97 patients 6-17 years of age , with ASD and ADHD , were treated with 1.2 mg/kg/day of atomoxetine during an 8 week double-blind placebo-controlled period . Here , we investigated effects on two parent-based secondary outcome measures , the Aberrant Behavior Checklist ( ABC ) and the Children 's Social Behavior Questionnaire ( CSBQ ) . RESULTS After 8 weeks of double-blind treatment , atomoxetine administration was associated with significant treatment effects on the ABC subscales Hyperactivity , Inappropriate Speech , and Stereotypic Behavior , and on the CSBQ subscale Fear for Changes . CONCLUSIONS Our study results indicate no beneficial effects of atomoxetine on social functioning . However , atomoxetine may ameliorate restricted and stereotyped behaviors and communication . This study has been registered in ClinicalTrials.gov ( www.clinicaltrials.gov ) under registration number NCT00380692 .
entities: 3081
entities: Intervention_Pharmacological
entities: Atomoxetine
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entities: Intervention_Pharmacological
entities: atomoxetine
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entities: Intervention_Pharmacological
entities: atomoxetine
entities: 3084
entities: Intervention_Control
entities: placebo-controlled
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entities: Intervention_Pharmacological
entities: atomoxetine
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entities: Intervention_Pharmacological
entities: atomoxetine
entities: 3087
entities: Outcome_Mental
entities: social functioning ;
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entities: Outcome_Mental
entities: stereotyped behaviors
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entities: Outcome_Mental
entities: inappropriate speech
entities: 3090
entities: Outcome_Mental
entities: fear of change
entities: 3091
entities: Outcome_Mental
entities: ABC subscales Hyperactivity
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entities: Outcome_Mental
entities: Inappropriate Speech
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entities: Outcome_Mental
entities: Stereotypic Behavior
entities: 3094
entities: Outcome_Mental
entities: CSBQ subscale Fear for Changes
entities: 3095
entities: Outcome_Mental
entities: stereotyped behaviors
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entities: Outcome_Mental
entities: communication
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entities: Participant_Condition
entities: autism spectrum disorder :
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entities: Participant_Age
entities: children and adolescents
entities: 3099
entities: Participant_Condition
entities: ASD and attention-deficit/hyperactivity disorder ( ADHD )
entities: 3100
entities: Participant_Sample-size
entities: 97
entities: 3101
entities: Participant_Age
entities: 6-17 years of age
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entities: Participant_Condition
entities: ASD and ADHD