passages: 4091
passages: document
passages: Salbutamol or mist in acute bronchiolitis . BACKGROUND The role of bronchodilators in the treatment of bronchiolitis remains controversial . METHODS A double-blind , placebo controlled trial was performed to evaluate the clinical response to nebulized salbutamol . One hundred and fifty-six infants aged between 7 weeks and 24 months who had had an episode of wheezing and other signs and symptoms of bronchiolitis were randomized to three groups as follows : ( i ) nebulized salbutamol was administered to 52 patients in group I at a dose of 0.15 mg/kg in 2 mL saline ; ( ii ) saline was nebulized to 52 patients in group II and ( iii ) in group III 52 patients received mist in a tent . All three groups were administered oxygen during the procedures . Treatment was repeated with the same agent after 30 min if the respiratory score was 5 or more . Respiratory rate , heart rate , oxygen saturation and presence of cyanosis , wheezing , retractions were recorded before and after each treatment . RESULTS The decrease in the respiratory score was 5.2 +/- 1.8 , 0.82 +/- 2.4 and 1.7 +/- 1.3 in group I , II and III , respectively . The decrease in group I was significantly higher than in the other groups . Heart rate was similar between groups . Oxygen saturation decreased in group I without reaching statistical significance . CONCLUSIONS Salbutamol was shown to be effective and safe in the treatment of acute bronchiolitis .
entities: 4092
entities: Intervention_Pharmacological
entities: Salbutamol
entities: 4093
entities: Intervention_Control
entities: mist
entities: 4094
entities: Intervention_Pharmacological
entities: salbutamol
entities: 4095
entities: Intervention_Pharmacological
entities: salbutamol
entities: 4096
entities: Intervention_Control
entities: saline
entities: 4097
entities: Intervention_Control
entities: saline
entities: 4098
entities: Intervention_Control
entities: mist
entities: 4099
entities: Intervention_Pharmacological
entities: oxygen
entities: 4100
entities: Intervention_Pharmacological
entities: Salbutamol
entities: 4101
entities: Outcome_Physical
entities: Respiratory rate , heart rate , oxygen saturation and presence of cyanosis , wheezing , retractions
entities: 4102
entities: Outcome_Physical
entities: respiratory score
entities: 4103
entities: Outcome_Physical
entities: Heart rate
entities: 4104
entities: Outcome_Physical
entities: Oxygen saturation
entities: 4105
entities: Outcome_Other
entities: effective
entities: 4106
entities: Outcome_Other
entities: safe
entities: 4107
entities: Participant_Condition
entities: acute bronchiolitis .
entities: 4108
entities: Participant_Sample-size
entities: One hundred and fifty-six
entities: 4109
entities: Participant_Age
entities: infants aged between 7 weeks and 24 months
entities: 4110
entities: Participant_Condition
entities: had an episode of wheezing and other signs and symptoms of bronchiolitis