passages: 35
passages: document
passages: Anti-emetic efficacy of prophylactic granisetron compared with perphenazine for the prevention of post-operative vomiting in children . We have compared the efficacy of granisetron with perphenazine in the prevention of vomiting after tonsillectomy with or without adenoidectomy in children . In a prospective , randomized , double-blind study , 90 paediatric patients , ASA I , aged 4-10 years , received granisetron 40 mg kg-1 or perphenazine 70 mg kg-1 ( n = 45 each ) intravenously immediately after an inhalation induction of anaesthesia . A standard general anaesthetic technique was employed throughout . A complete response , defined as no emesis with no need for another rescue antiemetic , during the first 3 h ( 0-3 h ) after anesthesia was 87 % with granisetron and 78 % with perphenazine ( P = 0.204 ) . The corresponding incidence during the next 21 h ( 3-24 h ) after anaesthesia was 87 % and 62 % ( P = 0.007 ) . No clinically serious adverse events were observed in any of the groups . We conclude that granisetron is a better anti-emetic than perphenazine for the long-term prevention of post-operative vomiting in children undergoing general anaesthesia for tonsillectomy .
entities: 36
entities: Intervention_Pharmacological
entities: granisetron
entities: 37
entities: Intervention_Pharmacological
entities: perphenazine
entities: 38
entities: Intervention_Pharmacological
entities: granisetron
entities: 39
entities: Intervention_Pharmacological
entities: perphenazine
entities: 40
entities: Intervention_Pharmacological
entities: granisetron
entities: 41
entities: Intervention_Pharmacological
entities: perphenazine
entities: 42
entities: Intervention_Pharmacological
entities: granisetron
entities: 43
entities: Intervention_Pharmacological
entities: perphenazine
entities: 44
entities: Intervention_Pharmacological
entities: granisetron
entities: 45
entities: Intervention_Pharmacological
entities: perphenazine
entities: 46
entities: Outcome_Physical
entities: Anti-emetic
entities: 47
entities: Outcome_Other
entities: efficacy
entities: 48
entities: Outcome_Physical
entities: prevention
entities: 49
entities: Outcome_Other
entities: efficacy
entities: 50
entities: Outcome_Physical
entities: complete response , defined as no emesis with no need for another rescue antiemetic
entities: 51
entities: Outcome_Physical
entities: corresponding incidence
entities: 52
entities: Outcome_Adverse-effects
entities: adverse events
entities: 53
entities: Outcome_Physical
entities: long-term prevention
entities: 54
entities: Outcome_Physical
entities: post-operative vomiting
entities: 55
entities: Participant_Age
entities: children .
entities: 56
entities: Participant_Condition
entities: tonsillectomy with or without adenoidectomy
entities: 57
entities: Participant_Age
entities: children
entities: 58
entities: Participant_Sample-size
entities: 90
entities: 59
entities: Participant_Age
entities: paediatric patients
entities: 60
entities: Participant_Age
entities: ASA I
entities: 61
entities: Participant_Age
entities: aged 4-10 years
entities: 62
entities: Participant_Age
entities: children undergoing general anaesthesia
entities: 63
entities: Participant_Condition
entities: for tonsillectomy