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passages: document
passages: Influence of lime juice on the severity of sickle cell anemia . BACKGROUND AND OBJECTIVES The pain in sickle cell anemia ( SCA ) is often triggered by dehydration , acidosis , and fever that are usually due to malaria . Intake of lime juice was recently demonstrated to facilitate clearance of the malaria parasite . It was therefore sought to determine whether regular intake of lime juice will ameliorate crisis , especially recurrent bone pain . DESIGN In this preliminary , open-labeled , randomized study , the effects of lime juice on the clinical and some laboratory characteristics of children with SCA were tested . RESULTS Among the 113 children with SCA studied in two hospitals , the 58 receiving lime treatment had lower rates of significant painful episodes than the 55 without lime ( 37 versus 83 crises in 6 months , and 0.64±0.11 versus 1.51±0.34 average rates per child , p < 0.001 ) . Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) . The mean hematocrit of the subjects ( 26.23±2.03 % ) at the end of the study was also higher , p < 0.001 . However , transfusion rate , presence of hepatomegaly , splenomegaly , and jaundice was similar . Treatment with lime did not cause any significant side-effect . CONCLUSIONS Regular intake of lime juice may be of great therapeutic and nutritional relevance in children with SCA .
entities: 2669
entities: Intervention_Pharmacological
entities: lime juice
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entities: Intervention_Pharmacological
entities: lime juice
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entities: Intervention_Pharmacological
entities: lime juice
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entities: Intervention_Pharmacological
entities: lime juice
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entities: Intervention_Control
entities: without lime
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entities: Intervention_Pharmacological
entities: lime juice
entities: 2675
entities: Outcome_Pain
entities: recurrent bone pain .
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entities: Outcome_Pain
entities: significant painful episodes
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entities: Participant_Condition
entities: sickle cell anemia .
entities: 2678
entities: Participant_Age
entities: children
entities: 2679
entities: Participant_Condition
entities: SCA
entities: 2680
entities: Participant_Sample-size
entities: 113
entities: 2681
entities: Participant_Age
entities: children
entities: 2682
entities: Participant_Condition
entities: SCA
entities: 2683
entities: Participant_Age
entities: children
entities: 2684
entities: Participant_Condition
entities: SCA