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passages: document
passages: Regional ventricular performance and exercise training in children and young adults after repair of tetralogy of Fallot : randomized controlled pilot study . BACKGROUND Public-health guidelines recommend patients with congenital heart disease to exercise . Studies have shown that patients with congenital heart disease can improve physical exercise capacity . The effect of training on regional ventricular performance has hardly been studied . We performed a pilot study to assess whether an exercise training program would result in adverse changes of regional ventricular performance in patients with corrected tetralogy of Fallot . METHODS AND RESULTS Multicenter prospective randomized controlled pilot study in patients with tetralogy of Fallot aged 10 to 25 years . A 12-week standardized aerobic dynamic exercise training program ( 3 one-hour sessions per week ) was used . Pre- and post-training cardiopulmonary exercise tests , MRI , and echocardiography , including tissue-Doppler imaging , were performed . Patients were randomized to the exercise group ( n=28 ) or control group ( n=20 ) . One patient in the exercise group dropped out . Change in tissue-Doppler imaging parameters was similar in the exercise group and control group ( change in right ventricle free wall peak velocity E ' exercise group , 0.8±2.6 cm/s ; control group , 0.9±4.1 ; peak velocity A ' exercise group , 0.4±2.4 m/s ; control group 4.6±18.1 cm/s ) . CONCLUSIONS This randomized controlled pilot study provides preliminary data suggesting that regional ventricular performance is well maintained during 3-month aerobic dynamic exercise training in children and young adults with repaired tetralogy of Fallot . This information might help patients adhere to current public-health guidelines . CLINICAL TRIAL REGISTRATION URL : http// : www.trialregister.nl . Unique identifier : NTR2731 .
entities: 3120
entities: Intervention_Physical
entities: exercise training
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entities: Intervention_Physical
entities: training
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entities: Intervention_Physical
entities: exercise training program
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entities: Intervention_Physical
entities: exercise training program
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entities: Intervention_Physical
entities: exercise
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entities: Intervention_Control
entities: control
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entities: Intervention_Physical
entities: exercise
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entities: Intervention_Physical
entities: exercise
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entities: Intervention_Control
entities: control
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entities: Intervention_Other
entities: exercise training
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entities: Outcome_Physical
entities: cardiopulmonary exercise tests , MRI , and echocardiography , including tissue-Doppler imaging
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entities: Outcome_Physical
entities: Change in tissue-Doppler imaging parameters
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entities: Participant_Age
entities: children and young
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entities: Participant_Condition
entities: adults after repair of tetralogy of Fallot
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entities: Participant_Condition
entities: patients with corrected tetralogy of Fallot .
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entities: Participant_Condition
entities: patients with tetralogy of Fallot
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entities: Participant_Age
entities: aged 10 to 25 years