passages: 1489
passages: document
passages: Trial design challenges when combining medication and parent training in children with pervasive developmental disorders . This paper presents the rationale for a 24-week , randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance , irritability and adaptive functioning . In this model , medication reduces tantrums , aggression and self-injury ; parent training promotes improvement in noncompliance and adaptive functioning . Thus , medication and parent training target related , but separate , outcomes . At week 24 , the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse . Both symptom reduction and functional improvement are important clinical treatment targets . Thus , experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice .
entities: 1490
entities: Intervention_Pharmacological
entities: medication
entities: 1491
entities: Intervention_Educational
entities: parent training
entities: 1492
entities: Intervention_Pharmacological
entities: risperidone
entities: 1493
entities: Intervention_Educational
entities: structured parent training
entities: 1494
entities: Intervention_Pharmacological
entities: risperidone
entities: 1495
entities: Outcome_Mental
entities: noncompliance
entities: 1496
entities: Outcome_Mental
entities: irritability
entities: 1497
entities: Outcome_Mental
entities: adaptive functioning
entities: 1498
entities: Outcome_Mental
entities: tantrums
entities: 1499
entities: Outcome_Mental
entities: aggression
entities: 1500
entities: Outcome_Mental
entities: self-injury
entities: 1501
entities: Outcome_Mental
entities: noncompliance and adaptive functioning .
entities: 1502
entities: Outcome_Mental
entities: symptom
entities: 1503
entities: Outcome_Mental
entities: functional
entities: 1504
entities: Participant_Age
entities: children
entities: 1505
entities: Participant_Condition
entities: pervasive developmental disorders