passages: 2177
passages: document
passages: Chronic vasodilator therapy with flosequinan in congestive heart failure . This study was conducted to determine the long-term effect of flosequinan , a new orally administered arterial and venous dilator , on the clinical course of patients with moderate to severe congestive heart failure . Seventeen patients on chronic digitalis and diuretic therapy were randomized to receive either flosequinan ( n = 9 ) or placebo ( n = 8 ) in a double-blind fashion . Changes in symptomatology , exercise performance , and left ventricular function were assessed serially during the two-month treatment period . During the course of therapy , a modest improvement in the symptom scores and functional classification of the flosequinan-treated patients was observed . Flosequinan evoked a significant increase in maximal exercise capacity . While long-term flosequinan administration also effected a progressive increase in resting heart rate , it did not consistently improve indices of left ventricular systolic function . The addition of chronic vasodilator therapy with flosequinan to standard digitalis-diuretic regimens is capable of inducing clinical improvement in patients with moderate to severe chronic heart failure . Trials involving larger patient populations will be necessary to confirm the results of this preliminary study and to determine the extent of clinical improvement , subpopulations benefited , role in heart failure therapeutics , and so forth .
entities: 2178
entities: Intervention_Pharmacological
entities: flosequinan
entities: 2179
entities: Intervention_Pharmacological
entities: flosequinan
entities: 2180
entities: Intervention_Pharmacological
entities: flosequinan
entities: 2181
entities: Intervention_Control
entities: placebo
entities: 2182
entities: Intervention_Pharmacological
entities: Flosequinan
entities: 2183
entities: Intervention_Pharmacological
entities: flosequinan
entities: 2184
entities: Intervention_Pharmacological
entities: flosequinan
entities: 2185
entities: Outcome_Other
entities: long-term effect
entities: 2186
entities: Outcome_Physical
entities: symptomatology
entities: 2187
entities: Outcome_Physical
entities: exercise performance
entities: 2188
entities: Outcome_Physical
entities: left ventricular function
entities: 2189
entities: Outcome_Physical
entities: symptom scores
entities: 2190
entities: Outcome_Physical
entities: functional classification
entities: 2191
entities: Outcome_Physical
entities: maximal exercise capacity .
entities: 2192
entities: Outcome_Physical
entities: resting heart rate
entities: 2193
entities: Outcome_Physical
entities: left ventricular systolic function .
entities: 2194
entities: Participant_Condition
entities: congestive heart failure .
entities: 2195
entities: Participant_Condition
entities: patients with moderate to severe congestive heart failure .
entities: 2196
entities: Participant_Sample-size
entities: Seventeen
entities: 2197
entities: Participant_Condition
entities: patients on chronic digitalis and diuretic therapy
entities: 2198
entities: Participant_Condition
entities: patients with moderate to severe chronic heart failure .