passages: 2009
passages: document
passages: [ Efficacy of paliperidone extended-release tablets in the improvement of social functions in schizophrenics : a randomized and controlled study ] . OBJECTIVE To explore the efficacy of paliperidone extended-release tablets in the improvement of social functions in schizophrenics . METHODS A total of 81 schizophrenics were randomly divided into study group with paliperidone extended-release tablets and control group with risperidone for a 12-week treatment . They were assessed and analyzed by positive and negative symptoms scales ( PANSS ) , social disability screening schedule ( SDSS ) and treatment emergent symptom scale ( TESS ) at baseline , 6 ( th ) weekend and 12 ( th ) weekend . RESULTS In study group , the factors and total scores of PANSS in the 12 ( th ) weekend of treatment [ ( 12.0 ± 2.8 ) , ( 12.1 ± 3.6 ) , ( 26.2 ± 5.0 ) , ( 50.2 ± 8.7 ) ] were all significantly lower than those at baseline [ ( 24.7 ± 5.3 ) , ( 23.8 ± 3.6 ) , ( 45.0 ± 2.9 ) , ( 93.5 ± 6.8 ) ] ( t = 9.60-16.78 , P < 0.05 ) . In study group , the positive factor , negative factor and total scores of PANSS in the 12 ( th ) weekend of treatment [ ( 12.0 ± 2.8 ) , ( 12.1 ± 3.6 ) , ( 50.2 ± 8.7 ) ] were all significantly lower than those in the 6 ( th ) weekend of treatment [ ( 14.2 ± 1.8 ) , ( 14.6 ± 2.4 ) , ( 56.5 ± 6.4 ) ] ( t = 2.58-4.26 , P < 0.05 ) . In the 12 ( th ) weekend of treatment , the factors and total scores of PANSS in study group [ ( 12.0 ± 2.8 ) , ( 12.1 ± 3.6 ) , ( 26.2 ± 5.0 ) , ( 50.2 ± 8.7 ) ] were all significantly lower than those in control group [ ( 16.9 ± 4.9 ) , ( 18.7 ± 5.3 ) , ( 32.5 ± 5.1 ) , ( 68.1 ± 13.0 ) ] ( t = -4.28 -- 5.67 , P < 0.05 ) . In study group , the total scores of SDSS in the 12 ( th ) weekend of treatment ( 5.93 ± 2.78 ) were significantly lower than those at baseline ( 13.9 ± 3.4 ) ( t = 10.83 , P < 0.05 ) . In study group , the total scores of SDSS in the 12 ( th ) weekend of treatment ( 5.9 ± 2.8 ) were significantly lower than those in the 6 ( th ) weekend of treatment ( 7.6 ± 2.9 ) ( t = 5.21 , P < 0.05 ) . But there was no significant improvement in control group ( t = 1.88 , P > 0.05 ) . In the 12 ( th ) weekend of treatment , the total scores of SDSS in study group ( 5.9 ± 2.8 ) were significantly lower than those in control group ( 8.8 ± 2.9 ) ( t = -4.49 , P < 0.05 ) . No severe adverse effect was reported in either group . CONCLUSION Paliperidone extended-release tablets are effective to improve social functions and psychiatric symptoms of schizophrenics .
entities: 2010
entities: Intervention_Pharmacological
entities: paliperidone
entities: 2011
entities: Intervention_Pharmacological
entities: paliperidone
entities: 2012
entities: Intervention_Pharmacological
entities: paliperidone
entities: 2013
entities: Intervention_Pharmacological
entities: risperidone
entities: 2014
entities: Outcome_Mental
entities: social functions
entities: 2015
entities: Outcome_Mental
entities: social functions
entities: 2016
entities: Outcome_Physical
entities: positive and negative symptoms scales ( PANSS )
entities: 2017
entities: Outcome_Physical
entities: social disability screening schedule ( SDSS )
entities: 2018
entities: Outcome_Physical
entities: treatment emergent symptom scale ( TESS )
entities: 2019
entities: Outcome_Physical
entities: factors and total scores of PANSS
entities: 2020
entities: Participant_Condition
entities: schizophrenics
entities: 2021
entities: Participant_Condition
entities: schizophrenics .
entities: 2022
entities: Participant_Sample-size
entities: 81
entities: 2023
entities: Participant_Condition
entities: schizophrenics