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passages: document
passages: Effect of simvastatin on hemostasis in patients with isolated hypertriglyceridemia . BACKGROUNDS/AIMS Elevated triglyceride levels seem to predispose to the earlier development and accelerated progression of coronary artery disease . In our study , we assessed for the first time whether simvastatin treatment affects coagulation and fibrinolysis in patients with isolated hypertriglyceridemia . METHODS The study included 39 patients with elevated triglyceride levels and peripheral artery sclerosis , treated for 90 days with either simvastatin ( 40 mg daily ) or placebo . Plasma lipids , glucose homeostasis markers and hemostasic variables were assessed at baseline and after treatment . RESULTS Simvastatin , but not placebo , administered to these patients reduced plasma levels/activity of fibrinogen ( from 3.5 ± 0.4 to 2.8 ± 0.3 g/l , p < 0.01 ) , factor VII ( from 144.2 ± 16.9 to 112.5 ± 14.0 % , p < 0.01 ) and plasminogen activator inhibitor-1 ( from 76.9 ± 13.5 to 50.2 ± 9.2 ng/ml , p < 0.001 ) , without a significant reduction in von Willebrand factor levels , and tended to prolong the prothrombin and partial thromboplastin times . CONCLUSION Our results suggest that statin treatment produces a multidirectional effect on coagulation and fibrinolysis in patients with isolated hypertriglyceridemia and that this treatment may bring some benefits to patients with elevated triglyceride levels .
entities: 2869
entities: Intervention_Pharmacological
entities: simvastatin
entities: 2870
entities: Intervention_Pharmacological
entities: simvastatin
entities: 2871
entities: Intervention_Pharmacological
entities: simvastatin
entities: 2872
entities: Intervention_Control
entities: placebo .
entities: 2873
entities: Intervention_Pharmacological
entities: Simvastatin
entities: 2874
entities: Intervention_Control
entities: placebo
entities: 2875
entities: Outcome_Physical
entities: coagulation and fibrinolysis
entities: 2876
entities: Outcome_Physical
entities: Plasma lipids , glucose homeostasis markers
entities: 2877
entities: Outcome_Physical
entities: hemostasic variables
entities: 2878
entities: Outcome_Physical
entities: plasma levels/activity of fibrinogen
entities: 2879
entities: Participant_Condition
entities: patients with isolated hypertriglyceridemia .
entities: 2880
entities: Participant_Condition
entities: patients with isolated hypertriglyceridemia .
entities: 2881
entities: Participant_Sample-size
entities: 39
entities: 2882
entities: Participant_Condition
entities: patients with elevated triglyceride levels and peripheral artery sclerosis