Chenglin Lou|Xiting Duan|Irène Altarelli|John A. Sweeney|Franck Ramus|Jingjing Zhao
White matter network connectivity deficits in developmental dyslexia
Shaanxi Normal University|Shaanxi Normal University|École Normale Supérieure - PSL|School for Advanced Studies in the Social Sciences|French National Centre for Scientific Research|Laboratoire de Sciences Cognitives et Psycholinguistique|University of Geneva|University of Cincinnati|École Normale Supérieure - PSL|School for Advanced Studies in the Social Sciences|French National Centre for Scientific Research|Laboratoire de Sciences Cognitives et Psycholinguistique|Shaanxi Normal University
number studies shown abnormal connectivity certain white matter pathways developmental dyslexia well correlations white matter pathways behavioral deficits however whether developmental dyslexia presents broader white matter network connectivity disruption currently unknown present study reconstructed white matter networks 26 dyslexic children 1161 131 years 31 agematched controls 1149 136 years using constrained spherical deconvolution tractography networkbased statistics nbs analysis performed identify network connectivity deficits dyslexic individuals network topological features measured based graph theory examine whether parameters correlate literacy skills whether explain additional variance previously established white matter connectivity abnormalities dyslexic children nbs analysis identified network connecting leftoccipitaltemporal cortex temporoparietal cortex decreased streamlines dyslexic children four network topological parameters clustering coefficient local efficiency transitivity global efficiency positively correlated literacy skills dyslexic children explained substantial proportion additional variance literacy skills beyond connectivity measures white matter pathways study first time reports disconnection local subnetwork left hemisphere dyslexia shows global white matter network topological properties contribute reduced literacy skills dyslexic children