Dustin Albert|Daniel W. Belsky|Des Crowley|Shawn J. Latendresse|Fazil Al?ev|Brien P. Riley|Cuie Sun|Danielle M. Dick|Kenneth A. Dodge
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial
abstract early interventions preferred method addressing behavioral problems highrisk children often modest effects identifying sources variation intervention effects suggest means improve efficiency one potential source variation genome conducted genetic analysis fast track randomized control trial 10yearlong intervention prevent highrisk kindergarteners developing adult externalizing problems including substance abuse antisocial behavior tested whether variants glucocorticoid receptor gene nr3c1 associated differences response fast track intervention found europeanamerican children variant nr3c1 identified singlenucleotide polymorphism rs10482672 associated increased risk externalizing psychopathology control group children decreased risk externalizing psychopathology intervention group children variation nr3c1 measured study associated differential intervention response africanamerican children discuss implications efforts prevent externalizing problems highrisk children public policy genomic era