Karima Lalani, Meredith O'Neal, Simone Lee Joannou, Bhanumathi Gopal, Tiffany Champagne-Langabeer
Helping Frontline Workers in Texas-A Framework for Resource Development
International journal of environmental research and public health
lowincome countries insufficient evidence hematological clinical cytogenetic molecular profiles among new cml patients therefore performed study among newly confirmed cml patients tikur anbesa specialized hospital tash ethiopia determine hematological clinical cytogenetic molecular profiles confirmed cml patients tertiary care teaching hospital addis ababa ethiopia facilitybased crosssectional study conducted evaluate hematological clinical cytogenetic molecular profiles confirmed cml patients tash august 2021 december 2022 structured questionnaire used collect patients sociodemographic information medical history physical examination blood samples also collected hematological cytogenetic molecular tests descriptive statistics used analyze sociodemographic hematological clinical cytogenetic molecular profiles study participants total 251 confirmed new cml patients recruited study majority patients male 151 602 chronic cp cml 213 847 median age 36 years median iqr wbc rbc hgb plt counts 2177 155623074 x103l 32 27236 x106l 93 8211 gdl 324 211499 x 103l respectively patients leukocytosis 928 956 992 patients developed anemia hyperleukocytosis neutrophilia respectively fatigue abdominal pain splenomegaly weight loss common signs symptoms observed among cml patients approximately 861 study participants philadelphia chromosome positive ph according fluorescence situ hybridization fish p210 major breakpoint protein transcript detected qualitative polymerase chain reaction pcr quantitative real time polymerase chain reaction pcr presentation cml patients presented hyperleukocytosis neutrophilia anemia tash addis ababa fatigue abdominal pain splenomegaly weight loss common signs symptoms observed cml patients cml patients diagnosed fish p120 detected cml patients diagnosed pcr majority cml patients arrive referral center advanced signs symptoms better decentralize service peripheral health facilities