Kesheng Wang, Chun Xu, Laurie A Theeke, Danqing Xiao, Xingguang Luo, Changchun Xie
Linear Mixed Model Analysis of Polygenic Hazard Score on Verbal Memory Decline in Alzheimer's Disease
Nursing research
adhesion g proteincoupled receptors adgrs recently become target intense research unique protein structure consists g proteincoupled receptor combined long adhesive extracellular domains suggests dual role cell signaling adhesion despite considerable progress understanding adgr signaling past years knowledge adgr protein networks still limited receptors interaction partners known thus far aimed identify novel adgrinteracting partners shed light cellular protein networks rely adgr function applied affinity proteomics utilizing tandem affinity purifications combined mass spectrometry analysis acquired proteomics data provides evidence adgrs functional roles synapses also intracellular membranes namely endoplasmic reticulum golgi apparatus mitochondria mitochondriaassociated membranes mams specifically found association adgrs several scaffold proteins membraneassociated guanylate kinases family elementary units secretase complex outerinner mitochondrial membrane mams regulators wnt signaling pathways furthermore nuclear localization adgr domains together physical interaction nuclear proteins several transcription factors suggests role adgrs gene regulation