S H Lavanya, L Kalpana, R M Veena, V D Bharath Kumar
Role-play as an educational tool in medication communication skills: Students' perspectives
Indian journal of pharmacology
recent findings linkage high blood pressure bp later development dementia given new prospects cerebral targetorgan damage hypertension added substance concept preventable senility aim study analyze impact hypertension circadian bp profile disturbed glucose metabolism cognitive function study population consisted 999 seventyyearold men populationbased cohort study uppsala sweden followed respect cardiovascular risk factors since age 50 years age 70 24hour ambulatory bp monitored together measurements insulin sensitivity glucose tolerance serum lipids lipoproteins cognitive function assessed minimental state examination trailmaking test high diastolic bp baseline predicted later impaired cognitive performance even excluding men previous stroke n 70 crosssectional measurements age 70 showed high 24hour bp nondipping insulin resistance diabetes related low cognitive function relationships hypertension cognitive impairment strongest untreated men data general population healthy elderly men indicate hypertension associated metabolic disturbances might susceptibility factors cognitive disorders findings add support possibilities intervention early stages cognitive decline ie manifest dementia