Gilbert R. Kaats|Harry G. Preuss|Harry A. Croft|Samuel C. Keith|Patti L. Keith
A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium
Integrative Health Technologies (United States)|Georgetown University Medical Center|Georgetown University|Integrative Health Technologies (United States)|Integrative Health Technologies (United States)
us surgeon generals report bone health suggests americas bonehealth jeopardy issued call action develop bonehealth plans incorporating components 1 improved nutrition 2 increased health literacy 3 increased physical activityto conduct comparative effectiveness research cer study comparing changes bone mineral density healthy women over40 aboveaverage compliance following one three bone health plans incorporating sgs three componentsusing openlabel sequential design 414 females 40 years age tested 176 agreed participate follow one three different bonehealth programs one plan contained bonehealth supplement 1000 ius vitamin d3 750 mg plantsourced form calcium one year two plans contained plant form calcium differing amounts vitamin d3 added bone health ingredients along components designed increase physical activity health literacy group completed baseline ending dxa bone density scans 43chemistry blood test panels 84item quality life inventory qol changes subjects annualized percent change bmd baseline using selfreports adherence subjects rankordered dichotomized compliant partially compliant based median rating comparisons also made treatment groups two theoretical ageadjusted expected groups nonintervention group group derived review previously published studies nonplant sources calciumthere significant differences baseline bmd volunteered versus completed per protocol pp lost attrition among subjects completing per protocol significant differences three groups baseline measurements bmd weight age body fat fatfree mass suggesting treatment groups statistically similar baseline three treatment groups subjects average compliance significantly greater increases bmd compared two expectedchange reference groups group following nutritionally comprehensive plan outperformed two groups three groups statistically significant differences baseline ending blood chemistry tests qol selfreportsthe increases bmd found three treatment groups cer stand marked contrast previous studies reporting interventions calcium vitamin d3 reduce agerelated losses bmd increase bmd increased compliance resulted increased bmd levels adverse effects found blood chemistry tests selfreported quality life daily tracking reports plans tested suggest significant improvement traditional calcium vitamin d3 standard care