Nicola Luigi Bragazzi|Vincenza Gianfredi|Milena Villarini|Roberto Rosselli|Ahmed Nasr|Amr Mahmoud Hussein|Mariano Martini|Masoud Behzadifar
Vaccines Meet Big Data: State-of-the-Art and Future Prospects. From the Classical 3Is (“Isolate–Inactivate–Inject”) Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview
University of Genoa|University of Perugia|University of Perugia|Azienda Sanitaria Locale Roma 3|University of Milano-Bicocca|University of Parma|University of Genoa|Iran University of Medical Sciences
vaccines public health interventions aimed preventing infectionsrelated mortality morbidity disability vaccines successfully designed infectious diseases preventable preexisting neutralizing specific antibodies communicable diseases additional immunological mechanisms elicited achieve full protection new vaccines particularly urgent nowadays society economic growth globalization immigration leading emergencereemergence old new infectious agents animalhuman interface conventional vaccinology socalled vaccinology 10 officially born 1796 thanks contribution edward jenner entering twentyfirst century vaccinology shifted classical discipline serendipity pasteurian principle three isolate inactivate inject played major role science characterized rational design plan vaccinology 30 shift possible thanks big data characterized different dimensions high volume velocity variety data big data sources include new cuttingedge highthroughput technologies electronic registries social media social networks among others current minireview aims exploring potential roles well pitfalls challenges big data shaping future vaccinology moving toward tailored personalized vaccine design administration