Aysegül Ilgaz, Ayse Dagistan Akgöz, Sebahat Gözüm
Impaired perception of cardiovascular risk and health literacy in individuals with high cardiovascular diseases risk from different socioeconomic levels in Antalya, Turkey
Australian journal of primary health
subjective wellbeing swb important measure mental health status previous research shown physical activity affect individuals wellbeing yet underlying molecular mechanism remains clarified study aim evaluate potential interactions mitochondrial genes physical activity pa well combined effects individual wellbeing swb phenotype data uk biobank enrolled study including nine aspects workjob satisfaction health satisfaction family relationship satisfaction friendships satisfaction financial situation satisfaction ever depressed whole week general happiness general happiness health belief life meaningful made analysis aspects separately firstly mitochondriawide association studies miwas conducted assess association mitochondrial single nucleotide polymorphisms snp aspect swb interaction analysis mitochondrial dna mtdna mutation pa performed evaluate joint effect swb status meanwhile two analysis made female male group separately well total samples control possible confounding factors including gender age townsend deprivation index tdi education alcohol consumption smoking habits 10 principal components miwas analysis identified 45 mtsnps associated 9 phenotypes swb example m15218a g mtcyb health satisfaction phenotype total subjects genderspecific analyses found 30 mtsnps females 58 males involving 13 mtgenes mtdnapa interaction analysis also identified 10 significant mtdnapa interaction sets swb instance m13020 c mtnd5 associated swb financial situation satisfaction phenotype subjects p 000577 addition miwas analysis identified 12 mtgene variants associated swb mtnd1 mtnd2 however mtdnapa interactions detected 7 mtdna affecting psychiatric disorders occurring friendships satisfaction phenotype m3394 c mtnd1 study results suggest implication interaction mitochondrial function physical activity risk psychiatric disorder development