Alexandre Vivot|M. Maria Glymour|Christophe Tzourio|Philippe Amouyel|Geneviève Chêne|Carole Dufouil
Association of Alzheimer’s related genotypes with cognitive decline in multiple domains: results from the Three-City Dijon study
Inserm|Bordeaux Population Health|Centre Hospitalier Universitaire de Bordeaux|Harvard University|Bordeaux Population Health|Centre Hospitalier Universitaire de Bordeaux|Inserm|Inserm|Pasteur Institute of Lille|Bordeaux Population Health|Centre Hospitalier Universitaire de Bordeaux|Inserm|Bordeaux Population Health|Centre Hospitalier Universitaire de Bordeaux|Inserm
several genetic polymorphisms associated late onset alzheimers disease load limited evidence whether polymorphisms predict intermediary stage outcomes cognitive changes prospective communitybased studies aim evaluate whether polymorphisms previously established predictors load also predict worse cognitive function accelerated decline across multiple cognitive domains analyzed data 3cdijon study 4931 respondents aged 65 examined 5 times 10 years neuropsychological assessment evaluated associations polymorphisms apoe cr1 bin1 clu picalm abca7 ms4a6a cd33 ms4a4e cd2ap level change 5 neuropsychological tests assuming dominant effect model optimize measurement used mixed regression model latent process cognitive domain global cognition mini mental state examination verbal fluency isaacs set test visual memory benton visual retention test information processing trail making test b literacy national adult reading test apoe associated accelerated decline global cognition verbal fluency two nonapoe genetic polymorphisms associated cognitive decline cr1 associated rate change verbal fluency bin1 associated rate change global cognition large prospective populationbased study dementiafree individuals cognitive domains associated established load risk alleles consistent associations global cognition verbal fluency