Chloe Verducci|Fizza Hussain|Elizabeth Donner|Brian D. Moseley|Jeffrey Buchhalter|Dale C. Hesdorffer|Daniel Friedman|Orrin Devinsky
SUDEP in the North American SUDEP Registry
Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati|Columbia University Irving Medical Center|University of Calgary|Hospital for Sick Children|University of Cincinnati
h3objectiveh3 obtain medical records family interviews deathrelated reports sudden unexpected death epilepsy sudep cases better understand sudep h3methodsh3 cases referred north american sudep registry nasr october 2011 june 2018 reviewed cause death determined consensus review available medical records death scene investigation reports autopsy reports nextofkin interviews reviewed cases sudep seizure type eeg mri sudep classification adjudicated 2 epileptologists h3resultsh3 237 definite probable cases sudep among 530 nasr participants sudep decedents median age 26 range 170 years death 38 female 143 sufficient information 40 generalized 60 focal epilepsy sudep affected full spectrum epilepsies benign epilepsy centrotemporal spikes n 3 1 intractable epileptic encephalopathies n 27 11 93 sudeps unwitnessed 70 occurred apparent sleep 69 patients prone 37 cases sudep took last dose antiseizure medications asms reported lifetime generalized tonicclonic seizures gtcs lt10 33 0 4 h3conclusionsh3 nasr participants commonly clinical features previously associated sudep risk young adult age asm nonadherence frequent gtcs however sizeable minority sudep occurred patients thought treatment responsive benign epilepsies results emphasize importance sudep education across spectrum epilepsy severities aim make nasr data biospecimens available researchers advance sudep understanding prevention