Richard N. Jones|Jennifer J. Manly|M. Maria Glymour|Dorene M. Rentz|Angela L. Jefferson|Yaakov Stern
Conceptual and Measurement Challenges in Research on Cognitive Reserve
Beth Israel Deaconess Medical Center|Harvard University|Columbia University Irving Medical Center|Harvard University|Brigham and Women's Hospital|Massachusetts General Hospital|Harvard University|Boston University|Columbia University Irving Medical Center|Columbia University
cognitive reserve broadly conceived encompasses aspects brain structure function optimize individual performance presence injury pathology reserve defined feature brain structure andor function modifies relationship injury pathology performance neuropsychological tasks clinical outcomes reserve challenging study two reasons first reserve hypothetical construct direct measures reserve available proxy variables latent variable models used attempt operationalize reserve second vivo measures neuronal pathology widely available challenging develop test models involving risk factor injury pathology moderator reserve outcome performance clinical status neither risk factor moderator measured directly discuss approaches quantifying reserve latent variable models emphasis application analysis data observational studies increasingly latent variable models used generate composites cognitive reserve based multiple proxies review theoretical ontological status latent variable modeling approaches cognitive reserve suggest research strategies advancing field