Muhammed O. Afolabi|Joseph Okebe|Nuala McGrath|Heidi J. Larson|Kalifa Bojang|Daniel Chandramohan
Informed consent comprehension in <scp>A</scp>frican research settings
MRC Unit the Gambia|London School of Hygiene & Tropical Medicine|MRC Unit the Gambia|University of Southampton|London School of Hygiene & Tropical Medicine|MRC Unit the Gambia|London School of Hygiene & Tropical Medicine
previous reviews participants comprehension informed consent information focused developed countries experience shown ethical standards developed western values may appropriate african settings research concepts unfamiliar undertook review describe informed consent comprehension defined measured african research settingswe conducted comprehensive search involving five electronic databases medline embase global health ethxweb bioethics literature database belit also examined african index medicus google scholar relevant publications informed consent comprehension clinical studies conducted subsaharan africa 29 studies satisfied inclusion criteria metaanalysis possible 21 studies conducted direct comparison participants comprehension domains informed consent eligible studiescomprehension key concepts informed consent varies considerably country country depends nature complexity study metaanalysis showed 47 total 1633 participants across four studies demonstrated comprehension randomisation 95 ci 139809 similarly 48 3946 participants six studies understanding placebo 95 ci 190775 30 753 participants five studies understood concept therapeutic misconception 95 ci 46667 measurement tools informed consent comprehension developed little validation assessment comprehension carried variable times disclosure study information uniform definition informed consent comprehension exists form basis development appropriate tool measure comprehension african participantscomprehension key concepts informed consent poor among study participants across africa vital need develop uniform definition informed consent comprehension low literacy research settings africa essential step towards developing appropriate tools adequately measure informed consent comprehension may consequently suggest adequate measures improve informed consent procedure