Enyew Getaneh Mekonen, Belayneh Shetie Workneh, Tadesse Tarik Tamir, Alebachew Ferede Zegeye
Prompt treatment of fever and its associated factors among under-five children in sub-Saharan Africa: A multilevel analysis of evidence from 36 countries
PloS one
limitations explanatory clinical trial framework include high expense implementing explanatory trials restrictive entry criteria participants redundant logistical processes limitations result slow evidence generation responsive population health needs yielding evidence generalizable clinically integrated trials integrate clinical research routine care represent potential solution challenge opportunity support learning health systems operational design features clinically integrated trials include focused scope simplicity design requirements leveraging existing data structures patient participation entire trial process features designed minimize barriers participation trial execution reduce additional research burdens participants clinicians alike broad adoption scalability clinically integrated trials dependent part continuing regulatory healthcare system payer support analysis presents framework strengths challenges clinically integrated trials based multidisciplinary expert think tank panel discussion included representatives patient populations academia nonprofit funding agencies us food drug administration industry