Antonia V. Bennett|Bryce B. Reeve|Ethan Basch|Sandra A. Mitchell|Mathew Meeneghan|Cláudio L. Battaglini|Abbie E. Smith?Ryan|Brett Phillips|Thomas C. Shea|William A. Wood
Evaluation of pedometry as a patient-centered outcome in patients undergoing hematopoietic cell transplant (HCT): a comparison of pedometry and patient reports of symptoms, health, and quality of life
University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|National Cancer Institute|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill
evaluated pedometry novel patientcentered outcome enables passive continuous assessment activity may provide information consequences symptomatic toxicity complementary selfreportadult patients undergoing hematopoietic cell transplant hct wore pedometers completed pro assessments transplant hospitalization 4 weeks 4 weeks postdischarge patient reports symptomatic treatment toxicities single items proctcae httphealthcaredeliverycancergovproctcae symptoms physical health mental health quality life promis global10 httpnihpromisorg assessed weekly 7day recall likert scales compared individually pedometry data summarized average daily steps per week using linear mixed modelsthirtytwo patients mean age 55 sd 14 63 male 84 white 56 autologous 43 allogeneic completed mean 46 sd 15 range 18 evaluable assessments regression model coefficients indicated withinperson decrements average daily steps associated increases pain 852 852 fewer steps per unit increase pain score p 0001 fatigue 886 p 0001 vomiting 518 p 001 shakingchills 587 p 001 diarrhea 719 p 0001 shortness breath 1018 p 005 reduction carrying social activities 705 p 001 physical activities 618 p 001 global physical health 101 p 0001 global mental health quality lifein small sample hct recipients severe symptoms impaired physical health restrictions performance usual daily activities associated statistically significant decrements objectively measured daily steps pedometry may valuable outcome measure validation anchor clinical research