Luis-Javier Márquez-Álvarez, José-Ignacio Calvo-Arenillas, Estíbaliz Jiménez-Arberas, Miguel-Ángel Talavera-Valverde, Ana-Isabel Souto-Gómez, Pedro Moruno-Miralles
A Q-method approach to perceptions of professional reasoning in occupational therapy undergraduates
BMC medical education
reactive arthritis rea rare seronegative inflammatory arthritis lacks exquisite classification rheumatic autoimmunity rea solely established using differential clinical diagnosis patient cohorts pathogenic triggers linked enteric urogenital microorganisms eg salmonella shigella yersinia campylobacter chlamydia reported inflammatory bowel disease ibd idiopathic enteric disorder coevolved attuned present gut microbiome dysbiosis correlated genesis enteropathic arthropathies like rea gut microbes symbolically modulate immune system homeostasis elementary varied disease patterns autoimmune disorders gutmicrobiota axis structured core hostmicrobe interactions execute imperative role discerning etiopathogenesis rea ibd study predicts molecular signatures rea coevolved ibd enveloped hostmicrobe interactions microbemicrobe interspecies communication using synonymous gene expression data selective microbes utilized combinatorial approach concomitant insilico workpipeline experimental validation corroborate findings insilico analysis involving text mining metabolic network reconstruction simulation filtering hostmicrobe interaction docking molecular mimicry studies results robust drug targets biomarkers coevolved ibd rea cross validation targets biomarkers done targeted gene expression analysis following nonprobabilistic convenience sampling studies performed substantiate hostmicrobe disease network consisting proteinmarkersymptomdiseasepathwaydrug associations resulting possible identification vital drug targets biomarkers pathways inhibitors ibd reaour study identified nah antiporter nhaa kynureninase kynu robust early essential hostmicrobe interacting targets ibd coevolved rea vital hostmicrobe interacting genes proteins pathways drugs include adenosine deaminase ada superoxide dismutase 2 sod2 catalase cat angiotensin converting enzyme ace carbon metabolism folate biosynthesis methotrexate serve potential prognostictheranostic biomarkers signatures extrapolated stratify rea related autoimmunity patient cohorts pilot studies