Huanhong Li, Jianhua Xu, Jonathan B Wiener
Comparing Environmental Risk Regulations in China and the United States
Risk analysis : an official publication of the Society for Risk Analysis
information physical association proteins extensively used studying cellular processes disease mechanisms however complete experimental mapping human interactome remain prohibitively difficult near future present map predicted human protein interactions distinguishes functional association physical binding network classifies 5 million protein pairs predicting 94009 new interactions high confidence experimentally tested subset predictions using yeast twohybrid analysis affinity purification followed quantitative mass spectrometry thus identified 462 new proteinprotein interactions confirmed predictive power network independent experiments address potential issues circular reasoning distinctive feature work analysis physical interactome unravels subnetworks mediating different functional physical subunits cell finally demonstrate utility network analysis molecular mechanisms complex diseases applying genomewide association studies neurodegenerative diseases analysis provides new evidence implying tomm40 factor involved alzheimers disease network provides highquality resource analysis genomic data sets genetic association studies particular interactome available via hprint web server wwwprintdborg