Jean Bousquet|Christian Jørgensen|M. Dauzat|Alfredo Cesario|T. Camuzat|Rodolphe Bourret|Nicolas Best|Josep M. Antó|Frédéric Abécassis|P Aubas|A. Avignon|Mélanie Badin|Jean Bousquet|Hubert Blain|Arnaud Bourdin|J. Bringer|William Camu|Guilhaume Cayla|David J. Costa|Philippe Courtet|Jean Paul Cristol|Pascal Demoly|J.-E. de La Coussaye|Pierre Fesler|Farés Gouzi|Jean?Christophe Gris|B. Guillot|Maurice Hayot|Claude Jeandel|O. Jonquet|Laurent Journot|Sylvain Lehmann|Gwenaelle Mathieu|Jacques Morel|G. Ninot|J. Pélissier|Marie Christine Picot|F. Radier-Pontal|Jean-Marie Robine|M. Rodier|François Roubille|Ariane Sultan|Anne Wojtusciszyn|Charles Auffray|Rudi Balling|Cristina Bárbara|Anne Cambon?Thomsen|Niels Chavannes|Alexander Chuchalin|George Crooks|Antoni Dedeu|Leonardo Fabbri|Judith García-Aymerich|Jawad Hajjam|Elisabete Melo Gomes|Susana Palkonen|F. Piette|Christophe Pison|David Price|Boles?aw Samoli?ski|Holger J. Schünemann|Peter J. Sterk|Panayiotis Yiallouros|Josep Roca|Philippe Van de Perre|Jacques Mercier
Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies
University of Montpellier|University of Montpellier|University of Montpellier|University of Montpellier
chronic diseases diseases long duration slow progression major ncds cardiovascular diseases cancer chronic respiratory diseases diabetes rheumatologic diseases mental health represent predominant health problem century prevention control ncds priority world health organization 2008 action plan united nations 2010 resolution european union 2010 council novel trend management ncds evolving towards integrative holistic approaches ncds intertwined ageing european innovation partnership active healthy ageing eip aha prioritised ncds tackle totality order reduce burden societal impact proposed ncds considered single expression disease different risk factors entities innovative integrated health system built around systems medicine strategic partnerships proposed combat ncds includes understanding social economic environmental genetic determinants well molecular cellular mechanisms underlying ncds ii primary care practicebased interprofessional collaboration iii carefully phenotyped patients iv development unbiased accurate biomarkers comorbidities severity follow patients v socioeconomic science vi development guidelines vii training viii policy decisions results could applicable countries adapted local needs economy health systems paper reviews complexity ncds intertwined ageing gives overview problem proposes two practical examples systems medicine medall applied allergy ncd comorbidities macvialr reference site european innovation partnership active healthy ageing keywords chronic disease comorbidities health system systems medicine patient active healthy ageing medall macvialr