Handan Wand, Sarita Naidoo, Vaneshree Govender, Tarylee Reddy, Jayajothi Moodley
Preventing Stunting in South African Children Under 5: Evaluating the Combined Impacts of Maternal Characteristics and Low Socioeconomic Conditions
Journal of prevention (2022)
biliary atresia ba neonatal fibroinflammatory cholangiopathy ductular reaction key pathogenic feature predicting poor survival mucosalassociated invariant mait cells enriched human liver display multiple roles liver diseases aimed investigate function mait cells ba first analyzed correlations liver mait cell clinical parameters survival alanine transaminase bilirubin histological inflammation fibrosis two public cohorts patients ba us china kaplanmeier survival analysis spearman correlation analysis employed survival data clinical parameters respectively next obtained liver samples peripheral blood ba control patients bulk rna sequencing flow cytometry analysis immunostaning functional experiments mait cells finally established two vitro coculture systems one rhesus rotavirus rrv infected coculture system model immune dysfunction human ba validated single cell rna sequencing multicellular system composed biliary organoids lx2 mait cells evaluate role mait cells ductular reaction liver mait cells ba positively associated low survival ductular reaction moreover liver mait cells activated exhibited wound healing signature highly expressed growth factor amphiregulin areg cell receptor tcrdependent manner antagonism areg abrogated proliferative effect ba mait cells cholangiocytes biliary organoids rrv infected coculture system recapitulated immune dysfunction human ba disclosed rrvprimed mait cells promoted cholangiocyte proliferation via areg induced inflammation fibrosis multicellular system mait cells exhibit wound healing signature depending tcr signaling promote ductular reaction via areg associated advanced fibrosis predictive low survival ba work funded national natural science foundation china grant 82001589 92168108 national key rd program china 2023yfa1801600 basic applied basic research foundation guangdong 2020a1515110921