Andressa Crystine da Silva Sobrinho, Grace Angelica de Oliveira Gomes, Carlos Roberto Bueno Júnior
Developing a Multiprofessional Mobile App to Enhance Health Habits in Older Adults: User-Centered Approach
JMIR formative research
studies conducted relationship depression thyroid diseases function causal relationship remains unclear using summary statistics genomewide association studies european east asian ancestry conducted 2sample bidirectional mendelian randomization estimate association mdd thyroid function european normal range tsh t4 t3 ft4 tpoab levels tpoabpositives east asian t4 thyroid diseases hypothyroidism hyperthyroidism hashimotos thyroiditis used mediation analysis evaluate potential mediators alcohol intake antidepressant association calculate mediated proportions observed significant causal association mdd hypothyroidism p 894 105 hyperthyroidism p 868 103 hashimotos thyroiditis p 397 105 among european ancestry mediated alcohol intake alcohol intake versus 10 years previously hypothyroidism p 0026 hashimotos thyroiditis p 0042 alcohol intake frequency hypothyroidism p 0015 antidepressant hypothyroidism p 0008 hashimotos thyroiditis p 0010 among east asian ancestry pmddhypothyroidism 0016 direction different pmddhyperthyroidism 0438 pmddhashimotos thyroiditis 0496 evidence bidirectional causal association thyroid function mentioned mdd among ancestry p 005 importantly observed significant causal association mdd risk hypothyroidism hyperthyroidism hashimotos thyroiditis among european ancestry alcohol intake antidepressant mediators prevention hypothyroidism hashimotos thyroiditis attributable mdd