Michael Gossop|Francis Keaney|Duncan Stewart|E. Jane Marshall|John Strang
A Short Alcohol Withdrawal Scale (SAWS): development and psychometric properties
Maudsley Hospital|Maudsley Hospital|Maudsley Hospital|Maudsley Hospital|Maudsley Hospital
abstract twentyeight wistar rats treated orally 20 ethanol solution divided two groups adult group n 19 aged group n 9 consisting animals aged 4 12 months respectively beginning treatment neurons basal nucleus region counted percentage choline acetyltransferaseimmunoreactive cholinergic neurons determined adjacent sections acetylcholine release cholineacetyltransferase activity cerebral cortex assessed animals nutritional parameters ethanol treated animals monitored found normal chronic exposure ethanol result global neuronal loss loss cholinergic neurons basal nucleus region however greater expression chatimmunoreactivity basal nucleus region tendency toward increased chat activity cerebral cortex control treated aged animals compared respectively adult ones observed findings suggest adaptive changes aged rats response possible cholinergic hypofunction manifested decreased release acetylcholine stimulated conditions