Cinnamon S. Bloss|Laura Ornowski|Elana Silver|Michele Cargill|Vance Vanier|Nicholas J. Schork|Eric J. Topol
Consumer perceptions of direct-to-consumer personalized genomic risk assessments
Scripps Research Institute|Scripps Health|Scripps Research Institute|Scripps Health|Scripps Clinic|Navigen (United States)|Navigen (United States)|Navigen (United States)|Scripps Health|Scripps Research Institute|Scripps Research Institute|Scripps Health|Scripps Clinic
evaluate consumer perceptions directtoconsumer personalized genomic risk assessments assess extent consumer characteristics may associated attitudes toward testingadult participants aged 1885 years age purchased personalized genomic risk test subsidized rate administered webbased health assessment included questions regarding perceptions attitudes toward undergoing testingassessments obtained 3640 individual study participants 497 expressed overall concerns undergoing testing logistic regression analysis revealed women likely express concerns odds ratio 120 95 confidence interval ci 104 139 individuals employed health care organization 123 95 ci 104 146 younger age 097 95 ci 096098 higher education 109 95 ci 104 114 higher trait anxiety 128 95 ci 120137 also significantly associated expressing concerns related testing attitudes regarding disclosure genetic risk nonpreventable disease also assessed none individuals sample indicated would definitely want know risk total 824 indicated would want knowamong individuals undergo directtoconsumer genetic testing approximately half still express concerns processexperience given concerns vary among different subgroups consumers clinical validity utility tests demonstrated tailored genetic education counseling services may benefit