Cagla Akay-Espinoza, Sarah E B Newton, Beth A Dombroski, Asha Kallianpur, Ajay Bharti, Donald R Franklin, Gerard D Schellenberg, Robert K Heaton, Igor Grant, Ronald J Ellis, Scott L Letendre, Kelly L Jordan-Sciutto
Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
crosssectional analysis investigates neuromotor functions two independent cohorts approximately 45 65yearold individuals different 18yearold adolescents using zurich neuromotor assessment2 zna2 total 186 individuals zurich longitudinal studies zls born 1950s mean age 651 years sd 12 year range ages 590675 years n 151 82 males 1970s mean age 436 years sd 13 year range ages 408466 years n 35 16 males tested zna2 14 motor tasks combined 5 motor components fine motor pure motor balance gross motor associated movements motor performance measures converted standard deviation scores sdss using normative data 18yearold individuals reference motor performance 45yearold individuals remarkably similar 18yearolds sds 022 025 apart associated movements 049 sds 65yearolds showed lower performance 18yearolds components zna2 smallest difference observed associated movements 067 sds largest gross motor skills 229 sds higher body mass index bmi associated better performance gross motor skills 45yearolds worse performance 65yearolds educational years positive effects gross motor skills ages exception associated movements neuromotor functions measured zna2 similar 45 18yearolds contrast age 65 years neuromotor components show significantly lower function norm population 18 years evidence found lastinfirstout hypothesis functions developed later adolescence associated movements gross motor skills vulnerable agerelated decline