Samaneh Nematzadeh, Zohreh Shahhosseini, Mahmood Moosazadeh, Zeinab Hamzehgardeshi
Sexual health literacy level and its related factors among married medical sciences college students in an Iranian setting: a web‑based cross‑sectional study
Reproductive health
alzheimers disease ad chronic progressive degenerative disease characterized cognitive dysfunction including verbal memory loss studies lacking examining longitudinal effect polygenic hazard score rey auditory verbal learning testdelayed total avdeltot score common measure verbal memory key step analyzing longitudinal changes cognitive measures using linear mixed model lmm choosing suitable covariance structure study aims determine association polygenic hazard score avdeltot score accounting repeated measures covariance structure avdeltot scores collected baseline 12 months 24 months 36 months 48 months 283 participants ad 347 cognitive normal 846 mild cognitive impairment alzheimers disease neuroimaging initiative bayesian information criterion statistic used select best covariance structure 10 covariance structures longitudinal analysis avdeltot scores multivariable lmm used investigate effect polygenic hazard score status low vs medium vs high changes avdeltot scores adjusted age gender education apoe4 genotype baseline minimental state examination score oneway analysis variance revealed significant differences avdeltot scores minimental state examination scores polygenic hazard scores among ad diagnoses baseline bayesian information criterion favored compound symmetry covariance structure lmm analysis using multivariate lmm apoe4 allele high polygenic hazard score value significantly associated avdeltot declines significant polygenic hazard score status followup visit interactions discovered findings provide first evidence effect polygenic hazard score status apoe4 allele declines verbal memory people ad