Eric S Martinez, David Redding
An osteopathic orientation to interprofessional education
Journal of osteopathic medicine
objective study evaluate clinical presentations adverse outcomes coronavirus disease 2019 covid19 patients systemic sclerosis ssc assess impact ssc features clinical course covid19 multicenter retrospective study ssc patients covid19 included clinical features ssc along detailed covid19 data extracted medical records patient interviews study included 112 patients mean age 514 128 years 902 female sscassociated interstitial lung disease ild evident 571 patients findings revealed hospitalization 255 respiratory support 163 intensive care unit admission 36 mortality rate 27 among ssc patients covid19 risk factors respiratory failure identified univariate analysis included ild 749 95 ci 1633446 1 comorbidity 455 95 ci 1391488 higher physician global assessment score last outpatient visit 273 95 ci 122610 use mycophenolate time infection 516 95 ci 1791499 notably 1 comorbidity emerged sole significant predictor need respiratory support covid19 578 95 ci 1142923 early postcovid19 period 17 patients reported progression raynaud phenomenon 106 developed new digital ulcers furthermore progression new onset dyspnea cough detected 283 114 patients respectively study suggests potential association adverse outcomes covid19 sscrelated ild severe disease activity use mycophenolate additionally highlights comorbidities independent risk factor need respiratory support covid19 cases