Mary Ryder, Freda Browne
Changing the delivery of continuing professional education: An action research approach
Nurse education today
increased survival provided access development evolution antiretroviral drugs arv greatly increased life expectancy people living hiv pwh also led increased occurrence diseases morbidities related aging individuals multiple comorbidities simultaneous use multiple medications also known polypharmacy common rational use medications essential study aims describe pharmacotherapeutic profile estimate prevalence polypharmacy identify factors associated polypharmacy cohort adult pwh referral unit rio de janeiro brazil crosssectional study including pwh arv received least one medical prescription outpatienthospitalized 2019 described proportion prescribed medications according arv anatomical therapeutic chemical atc classes stratified age 50 vs 50 years polypharmacy defined 5 medications prescribed beyond arv logistic regression models assessed demographic clinical factors associated polypharmacy total 143306 prescriptions 4547 pwh analyzed median age 444 years iqr354541 1615 356 50 years total 2958 651 participants selfidentified cisgender man 1365 300 cisgender woman 224 49 transgender women selfdeclared blackpardo 2582 651 1984 440 completed elementary education less median time since hiv diagnosis 109 years iqr62177 frequently prescribed concomitant medications nervous system 648 antiinfectives systemic use 600 alimentary tract metabolism 459 cardiovascular system 400 respiratory system 371 prevalence polypharmacy 506 95ci 492521 model results indicated older selfidentify cisgender woman less education longer time since hiv diagnosis increased odds polypharmacy found high rates polypharmacy concomitant medication use cohort pwh brazil targeted interventions prioritized prevent interactions improve treatment especially among individuals using central nervous system cardiovascular medications well certain groups cisgender women older individuals lower education standardized protocols continuous review patients therapeutic regimens implemented