Duc Quang Tran|Vaughn Barry|Ana G. Antun|Maria Ângela Gonçalves de Oliveira Ribeiro|Sidney F. Stein|Christine L. Kempton
Physician trust and depression influence adherence to factor replacement: a single?centre cross?sectional study
Emory University|Emory University|Emory University|Emory University|Emory University|Emory University
poor adherence factor replacement therapy among patients haemophilia lead joint bleeding eventual disabilitythe aim study determine patientrelated characteristics associated adherence factor replacement adults haemophiliaadults haemophilia recruited participate crosssectional study adherence measured using either validated hemophilia regimen treatment adherence scale veritaspro veritasprn questionnaire simple multiple regression analyses controlled confounding performed determine association patientrelated characteristics adherence factor replacement therapyof 99 subjects enrolled men 91 haemophilia 78 severe disease age ranged 18 62 years 95 functional health literacy 23 numerate mean adherence scores 456 sd 18 510 sd 15 prophylactic episodic regimen respectively lower score indicating better adherence multivariable analysis chronic medication longer duration followed haemophilia treatment centre higher physician trust better quality life associated higher adherence history depression associated lower adherencetwo potentially modifiable characteristics physician trust depression identified motivator barrier adherence factor replacement therapy promoting high level trust patient healthcare team well identifying treating depression may impact adherence factor replacement therapy accordingly reduce joint destruction