Sara Donetto, Shari Ortiz Baddan Sochandamandou, Maria Camila Garcia Duran, Philipp Hessel, Annie Zimmerman, Ricardo Araya Baltra, Fabio Idrobo
It's a delicate topic': Stigma, capabilities and young people's mental health in post-conflict Colombia
Global public health
study aimed comprehensively investigate neuroanatomical alterations associated idiopathic mnires disease md using voxelbased morphometry surfacebased morphometry techniques primary objective explore nuanced changes gray matter volume cortical thickness fractal dimension gyrification index sulcal depth md patients compared healthy controls hc additionally sought develop machine learning classification model utilizing neuroimaging features effectively discriminate md patients hc total 55 patients diagnosed unilateral md 70 hc enrolled study voxelbased morphometry surfacebased morphometry employed analyze neuroimaging data identify structural differences two groups selected neuroimaging features used build machine learning classification model distinguishing md patients hc analysis revealed significant reductions gray matter volume md patients particularly frontal cingulate gyri distinctive patterns alterations cortical thickness observed brain regions associated emotional processing sensory integration notably machine learning classification model achieved impressive accuracy 84 distinguishing md patients hc models precision recall md hc demonstrated robust performance resulting balanced f1scores receiver operating characteristic curve analysis confirmed discriminative power model supported area curve value 092 comprehensive investigation sheds light intricate neuroanatomical alterations md observed gray matter volume reductions distinct cortical thickness patterns emphasize diseases impact neural structure high accuracy machine learning classification model underscores diagnostic potential providing promising avenue identifying md patients findings contribute understanding mds neural underpinnings offer insights research exploring functional implications structural changes