J. Farren|N. Mitchell?Jones|Jan Y Verbakel|D. Timmerman|Maria Jalmbrant|T. Bourne
The psychological impact of early pregnancy loss
Queen Charlotte's and Chelsea Hospital|Imperial College London|Imperial College Healthcare NHS Trust|Queen Charlotte's and Chelsea Hospital|Imperial College London|Chelsea and Westminster Hospital NHS Foundation Trust|KU Leuven|University of Oxford|KU Leuven|Queen Charlotte's and Chelsea Hospital|Imperial College London|Queen Charlotte's and Chelsea Hospital|Imperial College London|Imperial College Healthcare NHS Trust|KU Leuven
early pregnancy loss epl common event scope longterm personal societal impact three decades worth published evidence profound psychological sequelae significant proportion women however wide variety outcomes screening instruments assessment timings geographical locations makes challenging form coherent picture morbidity within whole group subgroupsthis review aims investigate three questions 1 evidence depression anxiety posttraumatic stress disorder ptsd following miscarriage ectopic pregnancy women andor partners 2 intensity duration conditions compare without losses 3 patients found highest risk psychopathology answers questions salient daytoday clinical interactions experiencing epl whose psychological needs may prioritized also form basis tailoring healthcare policy terms screening treating associated psychological morbiditythe following databases searched start database july 2017 medline ovid interface 1948 onwards embase classic embase ovid interface 1947 onwards psychinfo ovid interface 1806 onwards search strategies developed using medical subject headings mesh concepts psychological morbidity anxiety depression ptsd pregnancy loss miscarriage ectopic pregnancy first expanded boolean operator linked together using included studies prospective cohort design including women men following epl majority experienced losses 24 weeks gestation reporting standardized psychometric measures anxiety depression posttraumatic stress disorder timing followup specified standardized across participants manuscript quality risk bias assessed using newcastleottawa scalewe found evidence significant depression anxiety first month following epl women partners also shown display depression anxiety albeit generally lower level also evidence posttraumatic stress symptoms relating epl three studiesin view high frequency epls significantly contribute overall burden psychopathology within population recognition impact important severely affected individuals may screened treated appropriately research establish risk factors promptly identify treat patients optimize management crucial