Majida Mramel, Mustafa El Alaoui, Rachid El Janati Idrissi
Barriers to clinical learning skills development among midwifery students and newly qualified midwives in Morocco: A qualitative study
Belitung nursing journal
microbiome differential abundance analysis remains challenging problem despite multiple methods proposed literature excessive zeros compositionality metagenomics data two main challenges differential abundance analysis propose novel method called analysis differential abundance pooling tobit models adapt overcome two challenges adapt uniquely treats zero counts leftcensored observations facilitate computation enhance interpretation adapt also encompasses theoretically justified way selecting nondifferentially abundant microbiome taxa reference hypothesis testing generate synthetic data using independent simulation frameworks show adapt consistent false discovery rate control higher statistical power competitors use adapt analyze 16s rrna sequencing saliva samples shotgun metagenomics sequencing plaque samples collected infants cohra2 study results provide novel insights association oral microbiome early childhood dental caries