Alessandro Giuliani
The application of principal component analysis to drug discovery and biomedical data
Drug discovery today
introduction fetal alcohol spectrum disorders fasd characterized variety multiple cognitive behavioral impairments intellectual attentional executive impairments commonly reported populations multiple neurodevelopmental disorders full scale intelligence quotient fsiq may proper measure intellectual abilities rarely interpreted fasd clinical practice heterogeneity cognitive profile deemed strong propose quantitative characterization heterogeneity strengths weaknesses profile differential analysis global cognitive fsiq elementary reasoning abilities large retrospective monocentric fasd sample methods using clinical cognitive data wechsler intelligence scale children 107 children fasd characterized subject heterogeneity variance scatter scaledcomposite scores searched strengths weaknesses specified intellectual functioning terms fsiq elementary reasoning general abilities index highest reasoning scaled score comparison standardization norms montecarlosimulated sample normalization data results performance children fasd lower subtests significant weakness working memory processing speed found increase variance scatter scores discordance assessment global cognitive functioning 28 borderline 23 deficient global elementary reasoning abilities 239 borderline 1514 deficient conclusion results question notion wisc profile heterogeneity fasd point working memory processing speed overimpairment global repercussions often preserved elementary reasoning abilities