Francesco Casanova, Qu Tian, Daniel S Williamson, Yong Qian, David Zweibaum, Jun Ding, Janice L Atkins, David Melzer, Luigi Ferrucci, Luke C Pilling
MRI-derived brain iron, grey matter volume, and risk of dementia and Parkinson's disease: Observational and genetic analysis in the UK Biobank cohort
Neurobiology of disease
evidence revealed 60 deaths underdeveloped nations linked adoption unhealthy lifestyles transtheoretical model ttm considered useful interventional approach smoking cessation drug addiction weight control however effectiveness improving changes dietary pattern physical activity alcohol consumption reported study aimed evaluating effectiveness ttmbased health education intervention promotion lifestyle changes among adults metabolic syndrome experimental design 352 participants metabolic syndrome allocated intervention control groups participants randomly assigned receive either standard cvd care ttm stagebased lifestyle modification intervention 12months lifestyle patterns assessed baseline endpoint mean difference subtotal ttm concept scores pre post intervention evaluated using paired ttest chisquare test independence used detect group differences categorical data participants preaction stage change dietary intake patterns physical activity habits baseline assessment difference groups intervention groups total level change toward adopting healthy lifestyle markedly p 0001 improved control group endpoint mean scores intervention groups stage change selfefficacy pros cons decisional balance improved significantly p 0001 baseline mean scores control groups pros cons decisional balance stage change also considerably p 005 improved baseline endpoint ttm based health education intervention effective improving participants lifestyles includes diet physical activity health care providers particularly nurses implement ttm stagedmatched educational intervention individuals risk cardiovascular diseases