Malihe Sadat Moayed, Amir Vahedian-Azimi, Keivan Gohari-Moghadam, Mohammad Asghari-Jafarabadi, Željko Reiner, Amirhossein Sahebkar
A Modified Physical Disability Screening Model after Treatment in the Intensive Care Unit: A Nationwide Derivation-Validation Study
Journal of clinical medicine
status prostatespecific antigen psa screening unclear china evidence regarding optimal frequency interval serial screening prostate cancer pca disputable study aimed depict status psa screening explore optimal screening frequency pca china 13year prospective cohort study conducted using chinese electronic health records research yinzhou studys data set total 420941 male participants aged 45 years included january 2009 june 2022 diagnosis pca cancerspecific death allcause death obtained electronic health records vital statistic system hazard ratios hrs 95 cis estimated using cox regression analysis cumulative rate ever psa testing 179 average annual percent change aapc 87 95 ci 36140 past decade china people older age higher bmi higher waist circumference tobacco smoking alcohol drinking behaviors higher level physical activity medication use comorbidities likely receive psa screening whereas lower education level widowed status less likely receive test people receiving serial screening 3 times 67 higher risk pca detection hr 167 95 ci 148188 64 lower risk pcaspecific mortality hr 036 95 ci 018070 28 lower risk overall mortality hr 072 95 ci 067077 people following serial screening strategy least every 4 years 25 higher risk pca detection hr 125 95 ci 113136 70 hr 030 95 ci 016057 23 hr 077 95 ci 073082 lower risks pcaspecific allcause mortality respectively study reveals low coverage psa screening china provides first evidence benefits general chinese population findings study indicate receiving serial screening least every 4 years beneficial overall pcaspecific survival studies based nationwide population longterm followup warranted identify optimal screening interval china