Manoj Murhekar|P Kamaraj|Muthusamy Santhosh Kumar|Siraj Ahmed Khan|Ramesh Reddy Allam|Pradip Barde|Bhagirathi Dwibedi|Suman Kanungo|Uday Mohan|Suman Sundar Mohanty|Subarna Roy|Vivek Sagar|Deepali Savargaonkar|Babasaheb V. Tandale|Roshan Kamal Topno|Gajanan Sapkal|C. P. Girish Kumar|R. Sabarinathan|Velusamy Saravana Kumar|Sailaja Bitragunta|Gagandeep Singh Grover|P V M Lakshmi|Chandra Mauli Mishra|Provash Chandra Sadhukhan|Prakash Kumar Sahoo|Shweta Singh|Chander Prakash Yadav|Asha Bhagat|Rashi Srivastava|Elangovan Ramya Dinesh|T. Karunakaran|C Govindhasamy|T Daniel Rajasekar|A. Jeyakumar|Suresh Arunachalam|D Augustine|Pankaj Kumar|Rajesh Kumar|Shanta Dutta|G S Toteja|Nivedita Gupta|Sanjay Mehendale
Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey
National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|Regional Medical Research Centre|Science Health Allied Research Education|National Institute for Research in Tribal Health|Regional Medical Research Centre|National Institute of Cholera and Enteric Diseases|King George's Medical University|National Institute for Implementation Research on Non-Communicable Diseases|Post Graduate Institute of Medical Education and Research|National Institute of Malaria Research|ICMR-National Institute of Virology|Rajendra Memorial Research Institute of Medical Sciences|ICMR-National Institute of Virology|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|Science Health Allied Research Education|Post Graduate Institute of Medical Education and Research|King George's Medical University|National Institute of Cholera and Enteric Diseases|Regional Medical Research Centre|King George's Medical University|National Institute of Malaria Research|ICMR-National Institute of Virology|ICMR-National Institute of Virology|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|National Institute of Epidemiology|Indian Council of Medical Research|Post Graduate Institute of Medical Education and Research|National Institute of Cholera and Enteric Diseases|National Institute for Implementation Research on Non-Communicable Diseases|Indian Council of Medical Research|Indian Council of Medical Research
backgroundthe burden dengue virus denv infection across geographical regions india poorly quantified estimated agespecific seroprevalence force infection number infections indiamethodswe communitybased survey 240 clusters 118 rural 122 urban selected 60 districts 15 indian states five geographical regions enumerated cluster randomly selected andriod application developed specifically survey 25 individuals age groups 58 years 917 years 1845 years sampled minimum 11 individuals age group 25 randomly selected individuals age group visited houses individuals consented survey included study age inclusion criterion purpose enumeration individuals residing household 6 months included sera tested centrally laboratory team scientific technical staff igg antibodies denv use indirect elisa calculated age group specific seroprevalence constructed catalytic models estimate force infectionfindingsfrom june 19 2017 april 12 2018 randomly selected 17 930 individuals three age groups blood samples collected tested 12 300 individuals 58 years n4059 917 years n4265 1845 years n3976 overall seroprevalence denv infection india 487 95 ci 435540 increasing 283 215362 among children aged 58 years 410 324501 among children aged 917 years 562 490631 among individuals aged 1845 years seroprevalence high southern 769 691832 western 623 553688 northern 603 493705 regions estimated number primary denv infections constant force infection model 12 991 357 12 825 12813 130 258 agedependent force infection model 8 655 425 7 243 6309 545 052 among individuals aged 545 years 30 indian states 2017interpretationthe burden dengue infection india heterogeneous evidence high transmission northern western southern regions survey findings useful making informed decisions introduction upcoming dengue vaccines indiafundingindian council medical research