Xinxin Wang, Shengnan Wang, Tingting Song, Kai Feng, Yongxin Li
Intergenerational Transmission of Mental Health Literacy and Its Mechanism: The Mediating Effect of Parent-Child Relationship and the Moderating Effect of School Mental Health Service
Psychology research and behavior management
impaired glucose tolerance measured fasting glucose glycated hemoglobin fasting insulin cardiovascular disease risk measured lowdensity lipoprotein cholesterol highdensity lipoprotein cholesterol triglycerides systolic blood pressure diastolic blood pressure causally related infertility genetic instruments suggest higher fasting insulin may increase infertility women observational evidence suggests shared etiology impaired glucose tolerance cardiovascular risk fertility problems study included twosample mendelian randomization mr analyses used genomewide association summary data publicly available biomarkers impaired glucose tolerance cardiovascular disease sexspecific genomewide association studies gwass infertility conducted norwegian mother father child cohort study 68 882 women average age 30 involved 81 682 pregnancies 47 474 male partners average age 33 55 744 pregnancies available genotype data provided selfreported information timetopregnancy use arts couples 12 infertile tried conceive 12 months used arts conceive applied inverse variance weighted method random effects pool data across variants series sensitivity analyses explore genetic instrument validity checked robustness genetic instruments lack unbalanced horizontal pleiotropy used methods robust population stratification findings corrected multiple comparisons bonferroni method eight exposures pvalue 000625 women increases genetically determined fasting insulin levels associated greater odds infertility 1 logpmoll odds ratio 160 95 ci 117 218 pvalue 0003 results robust sensitivity analyses exploring validity mr assumptions role pleiotropy cardiometabolic risk factors also evidence higher glucose glycated hemoglobin causing infertility women findings imprecise pass pvalue threshold multiple testing results lipids blood pressure close null suggesting cause infertility know underlying causes infertility woman man analyses involved couples conceived data circulating levels cardiometabolic risk factors opted conduct mr analysis using gwas summary statistics sexspecific genetic instruments cardiometabolic risk factors available results may affected selection misclassification bias finally characteristics study sample limit generalizability results populations noneuropean ancestry treatments lower fasting insulin levels may reduce risk infertility women moba cohort study supported norwegian ministry health care services norwegian ministry education research work supported european research council grant numbers 947684 101071773 293574 101021566 research council norway grant numbers 262700 320656 274611 southeastern norway regional health authority grant numbers 2020022 2021045 british heart foundation grant numbers chf2090003 aa18134219 open access funding provided norwegian institute public health funders role study design collection analysis interpretation data writing report decision submit article publication dal received research support national international government charitable bodies roche diagnostics medtronic research unrelated current work oaa consultant healthlytix rest authors declare competing interests exist na