Amanda Louize Félix Mendes, Brunna Thaís Luckwu de Lucena, Aline Menezes Guedes Dias De Araújo, Luciana Pimentel Fernandes de Melo, Leonardo Wanderley Lopes, Maria Fabiana Bonfim de Lima Silva
Teacher's voice: vocal tract discomfort symptoms, vocal intensity and noise in the classroom
CoDAS
hypothesized metabolic factors lifestyle factors socioeconomic factors may causal effect pelvic organ prolapse pop selected instruments corresponding genomewide association studies gwas identified independent single nucleotide polymorphisms strongly associated 12 potential risk factors summary statistics pop derived two gwas datasets serving discovery replication stage primary analysis involved use inversevariance weighting mendelian randomization mr method additional sensitivity mr analyses conducted univariable mendelian randomization uvmr analysis discovery replication stage provided evidence significant causal effects higher waisttohip ratio adjusted body mass index whradjbmi levels lower highdensity lipoprotein cholesterol hdlc levels lower educational attainment higher pop risk well suggestive positive causal effect triglycerides pop multivariable mendelian randomization mvmr analysis showed hdlc among three blood lipid fractions could reduce risk pop mediation analysis indicated hdlc may partially mediate effect whradjbmi pop risk causal effect educational attainment pop may mediated whradjbmi hdlc studys evidence supported causal relationship whradjbmi triglycerides hdlc educational attainment pop risk highlights clinicians may guide general female population control obesity blood lipid levels reduce risk pop