Xin Xia, Ying-Hua Li, Yi Liu, Zheng Su, Rui Qin, Zhao Liu, Ying Xie, Zhen-Xiao Huang, Xin-Mei Zhou, An-Qi Cheng, Jin-Xuan Li, Xiao-Wen Wei, Qing-Qing Song, Liang Zhao, Dan Xiao, Chen Wang
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toddlers conceived fertility treatment higher risk failing screening tool autism spectrum disorders asd toddlers conceived treatment compared children conceived infertility treatment children conceived infertility treatment ovulation induction without intrauterine insemination oiiui assisted reproductive technologies art appeared higher odds failing asd screening however results inconclusive need replication although studies examined risk asd art show association results mixed thus studies needed clarify association upstate kids study populationbased prospective cohort study children born new york state 2008 2010 children screened asd using modified checklist autism toddlers mchat ages 18 24 months new york state livebirth registry used identify newborns conceived without fertility treatment 13 ratio frequency matched region birth 18 24 months 3183 3063 mothers respectively completed mchat questionnaire current analysis included 2586 singletons 1296 twins mchat information 18 andor 24 months multivariable logistic regression generalized estimating equations gee used estimate odds ratios aor 95 confidence intervals ci adjustment covariates maternal age education plurality found 200 52 115 30 children failed mchat 18 24 months respectively associations use infertility treatment failing mchat 18 andor 24 months positive inconclusive failed exclude association 18 months aor 171 95 ci 081361 24 months aor 178 95 ci 066481 18 24 months aor 153 95 ci 078299 relationships oiiui art mchat failure 18 andor 24 months similar using fertility treatment vitro fertilization intracytoplasmic sperm injection consistently positively inversely associated mchat failure time point 18 months aor 120 95 ci 051283 24 months aor 093 95 ci 037231 18 24 months aor 109 95 ci 050260 mchat screening tool used asd risk assessment therefore mchat failure indicate asd diagnosis addition power detect associations small magnitude finally nonresponse followup may bias results despite lack precision positive associations art mchat failure suggest larger populationbased studies longer followup needed supported intramural research program eunice kennedy shriver national institute child health human development nichd contracts hhsn275201200005c hhsn267200700019c sponsor played role study design data collection data analysis interpretation writing manuscript decision submit article publication conflicts interest declare applicable