Nazeer Khan, Yasmin Mumtaz
Attitude of teaching faculty towards statistics at a medical university in Karachi, Pakistan
Journal of Ayub Medical College, Abbottabad : JAMC
recessive gjb2 variants common genetic cause hearing loss may contribute progressive sensorineural hearing loss snhl aim study build realistic predictive model gjb2related snhl using machine learning enable personalized medical planning timely intervention patients snhl confirmed biallelic gjb2 variants nationwide cohort 2005 2022 included different data preprocessing protocols computational algorithms combined construct prediction model randomly divided dataset training validation test sets ratio 72820 repeated process ten times obtain average result performance models evaluated using mean absolute error mae refers discrepancy predicted actual hearing thresholds enrolled 449 patients 2184 audiograms available deep learning analysis snhl progression identified models independent age sex genotype average hearing progression rate 061 db hl per year best mae linear regression multilayer perceptron long shortterm memory attention model 442 438 434 476 db hl respectively long shortterm memory model performed best average mae 434 db hl acceptable accuracy 4 years developed prognostic model uses machine learning approximate realistic hearing progression gjb2related snhl allowing design individualized medical plans recommending optimal followup interval population