Jessica A Malloy, Joya A Kemper, Stephanie R Partridge, Rajshri Roy
Empowering Young Women: A Qualitative Co-Design Study of a Social Media Health Promotion Programme
Nutrients
antipsychotics commonly prescribed treat range psychiatric conditions women reproductive age pregnancy including schizophrenia bipolar disorder anxiety depression autism spectrum disorder insomnia study aimed evaluate whether children exposed antipsychotic medication prenatally increased risk specific neurodevelopmental disorders learning difficulties populationbased cohort study used nationwide register data 1 january 200031 december 2020 pregnant women diagnosed psychiatric disorder liveborn singletons denmark finland iceland norway sweden cox proportional hazard regression yielded propensity scoreweighted hazard ratios ahrs 95 confidence intervals cis risk intellectual speech language learningdevelopmental disorders composite outcome listed disorders defined poor performance scoring within lowest quartile national school tests mathematics language arts estimated propensity scoreweighted risk ratios arrs using poisson regression analysed data denmark separately pooled results using random effects metaanalysis among 213302 children median followup 67 years 11 626 55 exposed antipsychotics prenatally adjusted risk estimates suggest increased risk neurodevelopmental disorders ahr 106 95 ci 094120 composite outcome poor academic performance arr 104 95 ci 091118 mathematics 100 95 ci 087115 language arts results generally consistent across individual medications trimesters exposure sibling sensitivity analyses findings large multinational cohort study suggest little increased risk child neurodevelopmental disorders learning difficulties prenatal exposure antipsychotics findings assist clinicians women managing mental illness pregnancy study funded nordforsk nordic program health welfare nordic pregnancy drug safety studies project 83539 research council norway international pregnancy drug safety studies project 273366 research council norway centres excellence funding scheme project 262700 unsw scientia programme awards ps46019 ps46019a