Yi Liu, Runyu Yang, Hui Feng, Yue Du, Bingyu Yang, Mengyao Zhang, Pengcheng He, Bohan Ma, Fan Niu
Adverse events reporting of XPO1 inhibitor - selinexor: a real-word analysis from FAERS database
Scientific reports
current evidence suggests potential heightened vulnerability smokers severe coronavirus disease covid19 outcomes study aimed analyze clinical outcomes mortality related tobacco use cohort hospitalized brazilian covid19 patients retrospective cohort study analyzed adults hospitalized covid19 brazil using sivepgripe database official data reported public private healthcare facilities monitoring severe acute respiratory syndrome cases brazil inclusion criteria patients 18 years age positive rtqpcr test sarscov2 analysis focused inhospital mortality considering smoking exposure variable included covariates age gender comorbidities smoking history collected selfreported field database statistical analyses included descriptive statistics crude odds ratios multivariable binary logistic regression study included 2124285 covid19 patients among 44774 21 smokers average age smokers higher neversmokers 653 years vs 597 years clinical outcomes revealed smokers higher rates intensive care unit admission 516 vs 372 neversmokers invasive ventilatory support 315 vs 202 neversmokers higher mortality 427 vs 318 never smokers multivariable analysis smokers demonstrated heightened risk death aor 123 95 ci 119125 large populationalbased cohort study confirms current evidence underscore critical importance recognizing smoking substantial risk factor adverse outcomes covid19 patients