Marwa Y Shaheen, Amani M Basudan, Abdulrahman M Almubarak, Abeer S Alzawawi, Fatemah M Al-Ahmari, Hajer A Aldulaijan, Hani Almoharib, Nahed Y Ashri
Dental Students' Perceptions Towards E-learning in Comparison With Traditional Classroom Learning
Cureus
bone metastasis common consequence advanced prostate cancer bisphosphonates used manage symptoms currently curative treatments available altered tumour cell glycosylation hallmark cancer important driver malignant phenotype prostate cancer sialyltransferase st6gal1 upregulated studies show st6gal1mediated aberrant sialylation nglycans promotes prostate tumour growth disease progression monitor st6gal1 tumour serum samples men aggressive prostate cancer using vitro vivo models investigate role st6gal1 prostate cancer bone metastasis st6gal1 upregulated patients prostate cancer tumours spread bone promote prostate cancer bone metastasis vivo mechanisms involved multifaceted involve modification premetastatic niche towards bone resorption promote vicious cycle promoting development m2 like macrophages regulation immunosuppressive sialoglycans furthermore using syngeneic mouse models show inhibiting sialylation block spread prostate tumours bone study identifies important role st6gal1 26 sialylated nglycans prostate cancer bone metastasis provides proofofconcept data show inhibiting sialylation suppress spread prostate tumours bone highlights sialic acid blockade exciting new strategy develop new therapies patients advanced prostate cancer prostate cancer research mark foundation cancer research medical research council prostate cancer uk