Barry Smith, Sivaram Arabandi, Mathias Brochhausen, Michael Calhoun, Paolo Ciccarese, Scott Doyle, Bernard Gibaud, Ilya Goldberg, Charles E Kahn, James Overton, John Tomaszewski, Metin Gurcan
Biomedical imaging ontologies: A survey and proposal for future work
Journal of pathology informatics
evaluate advantage contractubex gel regards influence vascularisation pigmentation thickness surface size configuration elisticity postsurgical scars children cheilorinoplasty comparison absence systematized topical treatment prospective noninterventional observational multicentered parallel groups open controlled study included 60 patients aged 25 months older postsurgical scars first cheilorinoplasty 714 day operation patients randomized 2 groups 30 patients group patients get applications contractubex gel 3 times day morning afternoon evening accordance patient information leaflet ii group control group regular therapy postsurgical scars without treatment without application oils gels anticsarring action period medicine usage 9 months patient patient observation duration 18 months analysis primary well secondary efficacy criteria total grade based posas scale reported investigatorparent 3 6 12 18 months observation groups positive statistically significant dynamics registered time contractubex group results statistically significantly better control group positive dynamics achieved quickier main group contol group observe already 3 months therapy whole treatment observation phase 18 months therapy additionally conducted photodocumentation postsurgical scar development dynamics terms study confirms positive effect surgery absence visual data regarding keloids hyperthrophic scars formation patients groups adverse events pain itch burning longrun hyperemia registered whole period os study conducted study shown high efficacy safety contractubex usage treatment postsurgical scars children congenital cleft lip palate 25 months old statistically significant advantage therapy contractubex demonstrated comparison control group regular topical treatment obtained results allow recommend contractubex gel effective safe medicine treatment scarring surgeries kids directly sutures removal