María Teresa Vidán|Vendula Blaya?Nováková|E. Sánchez|Javier Ortíz|José A. Serra?Rexach|Héctor Bueno
Prevalence and prognostic impact of frailty and its components in non?dependent elderly patients with heart failure
Universidad Complutense de Madrid|Hospital General Universitario Gregorio Marañón|Hospital General Universitario Gregorio Marañón|Agencia de Evaluación de Tecnologías Sanitarias|Instituto de Salud Carlos III|Hospital Universitario Ramón y Cajal|Hospital General Universitario Gregorio Marañón|Hospital General Universitario Gregorio Marañón|Universidad Complutense de Madrid|Universidad Complutense de Madrid|Spanish National Centre for Cardiovascular Research|Hospital Universitario 12 De Octubre
aims aim study evaluate prevalence clinical features independent impact frailtya geriatric syndrome characterized decline physiological systemsand components prognosis heart failure hf hospitalization methods results frailhf prospective cohort study including 450 nondependent patients 70 years old hospitalized hf frailty screened according biological phenotype criteria low physical activity weight loss slow walking speed weak grip strength exhaustion independent influence frailty mortality functional decline readmission risks calculated adjusted hf characteristics comorbidities mean age 80 6 years 76 fulfilled frailty criteria frail patients older often female showed differences chronic comorbidities lvef ntprobnp levels slow walking speed discriminative component frail 892 nonfrail patients 26 overall 1year survival 89 nonfrail group 75 frail subjects p 0003 adjusting age gender chronic acute comorbidities nyha ntprobnp frail patients showed higher risks 30day functional decline odds ratio 220 95 confidence interval ci 119408 1year allcause mortality hazard ratio hr 213 95 ci 107423 1year readmission 196 95 ci 114334 association individual components 1year adjusted mortality risk hr 214 95 ci 105439 low physical activity hr 177 95 ci 095329 slow walking speed conclusion frailty highly prevalent even among nondependent elderly hf patients independent predictor early disability longterm mortality readmission individual frailty components may useful risk prediction