Arti Hurria|Sunita K. Patel|Joanne Mortimer|Thehang Luu|George Somlo|Vani Katheria|Rupal Ramani|Katherine Hansen|Tao Feng|Carolyn Chuang|Cheri Geist|Daniel Silverman
The Effect of Aromatase Inhibition on the Cognitive Function of Older Patients With Breast Cancer
City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|City Of Hope National Medical Center|University of California, Los Angeles|University of California, Los Angeles
introduction study evaluated association aromatase inhibitor ai therapy cognitive function 6month period cohort patients aged 60 years compared agematched healthy control group evaluated changes regional cerebral metabolism measured positron emission tomography pet scans brain done subset patient cohort patients methods thirtyfive patients 32 evaluable 35 healthy controls recruited study patients breast cancer completed neuropsychological battery selfreported memory questionnaire geriatric assessment initiation ai therapy 6 months later agematched healthy control participants completed assessments time points patient group results significant decline cognitive function seen among individuals receiving ai pretreatment 6 months later compared healthy controls pet cohort period standardized volume interest statistical parametric mapping analyses detected specific changes metabolic activity baseline followup uniquely ai patients significantly medial temporal lobes conclusion although patients undergoing ai treatment changes neuropsychological performance compared healthy controls 6month period regionally specific changes cerebral metabolic activity identified interval patient group additional longitudinal followup needed understand potential clinical implications findings