Stig-Johan Wiklund, Katharine Thorn, Heiko Götte, Kimberley Hacquoil, Gaëlle Saint-Hilary, Alex Carlton
Going beyond probability of success: Opportunities for statisticians to influence quantitative decision-making at the portfolio level
Pharmaceutical statistics
genuinely new discovery transcends existing knowledge despite many analyses systems neuroscience neglect test new speculative hypotheses benchmark empirical facts analyses inadvertently use circular reasoning present existing knowledge new discovery discuss problem confound key results estimate affected three thousand studies network neuroscience last decade suggest future studies reduce problem limiting use speculative evidence integrating existing knowledge benchmark models rigorously testing proposed discoveries models conclude summary practical challenges recommendations