Kamrun Nahar Koly, Jobaida Saba, Enryka Christopher, Anan Nisat Nabela Hossain, Taslima Akter, Zakia Rahman, Helal Uddin Ahmed, Julian Eaton
Assessment of the feasibility of a community-based mental health training programme for persons with disabilities by non-specialists from different stakeholders' perspectives in Bangladesh
BMC health services research
cognitive impairment widespread feature schizophrenia affecting nearly 80 patients prior research linked anticholinergic burden psychiatric medications cognitive deficits however impact anticholinergic burden medications physical morbidity remains underexplored study aimed evaluate anticholinergic burden psychiatric physical medications patients schizophrenia assess impact cognitive function total 178 patients schizophrenia recruited assessments included ad hoc questionnaire collecting demographic clinical data anticholinergic burden evaluated using cumulative drug burden index cdbi participant cognitive function assessed using matrics psychopathology measured using panss cdss cains cgis statistical analysis included students ttests anova pearson correlations multiple linear regressions average cdbi 13 sd 09 model developed explained 4080 variance variable greatest weight cdbi b 11148 p 0010 negativeexpression b 2740 p 0011 negativeexperiential b 1175 p 0030 symptoms also associated lower global cognitive score however years education b 5140 p 0001 cigarettes per day b 1331 p 0001 predicted better global cognitive score study identified specific predictors global cognition schizophrenia anticholinergic burden emerging strongest factor findings underscore importance considering anticholinergic burden treatments addition negative symptoms designing interventions optimize maintain cognitive function patients schizophrenia