William G Kearns, J Georgios Stamoulis, Joseph Glick, Lawrence Baisch, Andrew Benner, Dalton Brough, Luke Du, Bradford Wilson, Laura Kearns, Nicholas Ng, Maya Seshan, Raymond Anchan
The Application of Knowledge Engineering via the Use of a Biomimetic Digital Twin Ecosystem, Phenotype-Driven Variant Analysis, and Exome Sequencing to Understand the Molecular Mechanisms of Disease
The Journal of molecular diagnostics : JMD
maternal antenatal depression experienced around conception pregnancy may adversely affect child development study explores three potential mechanisms effects antenatal depression childrens developmental delays 23 years gestational age child continued depressive symptoms postnatally interrupted breastfeeding practices mothers n 2888 3450 children including 2303 singletons 1147 multiples upstate kids cohort provided data linked hospital discharge data combined mothers reports identify women moderate severe antenatal depression gestational age extracted birth certificates mothers completed depression screener 4 months postpartum reported breastfeeding practices 4 12 months postpartum completed developmental delay screener children 24 30 36 months unadjusted path analysis models mothers antenatal depression postnatal depressive symptoms breastfed fewer months translated children likely developmental delays gestational age mediator effects similar across girls boys singletons twins largely held adjusting covariates main limitations relatively advantaged sample reliance maternal report maternal antenatal depression may impact child development continued depressive symptoms postpartum period reduced breastfeeding duration suggesting additional targets intervention