Marian Loveday|Kristina Wallengren|James C.M. Brust|John P. Roberts|Anna Voce|Bruce Margot|Jacqueline Ngozo|Iqbal Master|Gail H. Cassell|Nesri Padayatchi
Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa
South African Medical Research Council|Montefiore Medical Center|Albert Einstein College of Medicine|Centers for Disease Control and Prevention|University of KwaZulu-Natal|Harvard University|Centre for the AIDS Programme of Research in South Africa
kwazulunatal south africa predominantly rural province high burden tuberculosis tb multidrugresistant tb mdrtb human immunodeficiency virus hiv infectionto determine effective care model comparing mdrtb treatment outcomes communitybased sites traditional care central specialised hospitala nonrandomised observational prospective cohort study comparing communitybased centralised care patients communitybased sites closer home easier access care homebased care available treatment initiationfour communitybased sites treated 736 patients 813 treated centralised hospital total 1549 patients overall 75 hiv coinfected community 76 vs hospitalised 73 p 045 86 received antiretroviral therapy community 91 vs hospitalised 82 p 022 multivariate analysis mdrtb patients likely successful treatment outcome treated communitybased site adjusted 143 p 001 however outcomes four communitybased sites heterogeneous site 1 demonstrating homebased care associated increased treatment success 72 compared success rates 5260 three sitescommunitybased care mdrtb patients effective care central specialised hospital homebased care increased treatment success