Samantha L Quaife|Mamta Ruparel|Jennifer Dickson|Rebecca J. Beeken|Andy McEwen|David R Baldwin|Angshu Bhowmik|Neal Navani|Karen Sennett|Stephen W. Duffy|Jane Wardle|Jo Waller|Sam M. Janes
Lung Screen Uptake Trial (LSUT): Randomized Controlled Clinical Trial Testing Targeted Invitation Materials
University College London|University College London|University College London|University College London|University of Leeds|Nottingham University Hospitals NHS Trust|Homerton University Hospital|University College Hospital|University College London|Queen Mary University of London|University College London|Queen Mary University of London|University College London|King's College London|University College London
rationale low uptake lowdose computed tomography ldct lung cancer screening particularly current smokers low socioeconomic position compromises effectiveness equityobjectives compare effect targeted lowburden stepped invitation strategy versus control uptake hospitalbased lung health check appointments offering ldct screeningmethods twoarm blinded betweensubjects randomized controlled trial 2012 participants selected 16 primary care practices using criteria 1 aged 60 75 years 2 recorded current smoker within last 7 years 3 prespecified exclusion criteria contraindicating ldct screening groups received stepped sequence preinvitation invitation reminder letters primary care practitioner offering prescheduled appointments key manipulation accompanying leaflet intervention groups leaflet targeted psychological barriers provided lowburden information mimicking concept uk ministry transports annual vehicle test mot lungsmeasurements main results uptake 526 difference intervention 523 control 529 groups unadjusted odds ratio 098 95 confidence interval ci 082116 adjusted 098 95 ci 082117 analyses current smokers less likely attend adjusted 070 95 ci 056086 former smokers socioeconomic deprivation significantly associated lower uptake control group p 001conclusions intervention improve uptake regardless trial arm uptake considerably higher previous clinical realworld studies particularly given samples predominantly lower socioeconomic position smokers strategies common groups including lung health check approach could represent minimum standardclinical trial registered wwwclinicaltrialsgov nct02558101 registered prospectively international standard registered clinicalsocial study n21774741