Zulfitri Azuan Mat Daud|Boniface Tubie|Marina Sheyman|Robert Osia|J. E. Adams|Sharon Tubie|Pramod Khosla
Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients
Wayne State University|Park Nicollet Clinic|Wayne State University|Park Nicollet Clinic|Park Nicollet Clinic|Park Nicollet Clinic|Park Nicollet Clinic|Wayne State University
chronic hemodialysis patients experience accelerated atherosclerosis contributed dyslipidemia inflammation impaired antioxidant system vitamin e tocotrienols possess antiinflammatory antioxidant properties however impact dietary intervention vitamin e tocotrienols unknown populationa randomized doubleblind placebocontrolled parallel trial conducted 81 patients undergoing chronic hemodialysis subjects provided daily capsules containing either vitamin e tocotrienolrich fraction trf 180 mg tocotrienols 40 mg tocopherols placebo 048 mg tocotrienols 088 mg tocopherols endpoints included measurements inflammatory markers creactive protein interleukin 6 oxidative status total antioxidant power malondialdehyde lipid profiles plasma total cholesterol triacylglycerols highdensity lipoprotein cholesterol well cholesterylester transfer protein activity apolipoprotein a1trf supplementation impact nutritional inflammatory oxidative status biomarkers time compared baseline within group oneway repeated measures analysis variance compared placebo group particular time point independent ttest however trf supplemented group showed improvement lipid profiles 12 16 weeks intervention compared placebo respective time points normalized plasma triacylglycerols cf baseline trf group reduced 33 mgdl p0032 36 mgdl p0072 12 16 weeks intervention significant improvement seen placebo group similarly normalized plasma highdensity lipoprotein cholesterol higher p005 trf group compared placebo week 12 week 16 changes trf group week 12 week 16 associated higher plasma apolipoprotein a1 concentration p002 lower cholesterylester transfer protein activity p0001trf supplementation improved lipid profiles study maintenance hemodialysis patients multicentered trial warranted confirm observations