Jorge E Caviedes, James J Cimino
Towards the development of a conceptual distance metric for the UMLS
Journal of biomedical informatics
lassa fever viral haemorrhagic fever options diagnosis treatment also underresearched knowledge gaps epidemiology pointofcare bedside test diagnosing lassa fever adhering reassured criteria currently available urgently needed west african regions high lassa fever burden aimed assess validity feasibility rapid diagnostic test rdt confirm lassa fever people nigeria estimated diagnostic performance relasv panlassa rdt zalgen labs frederick md usa researchuseonly test compared rtpcr reference standard 217 participants federal tertiary hospital abakaliki nigeria recruited participants feb 17 2022 april 17 2023 rdt performed using capillary blood patient bedside using plasma laboratory performance test based reassured criteria assessed user friendliness rapidity robustness sensitivity specificity participants aged 0 85 years median age 330 years iqr 220443 24 participants younger 18 years 107 50 participants women 109 50 men one participant missing sex data although specificity panlassa rdt high 90 sensitivity bedside using capillary blood estimated 4 95 ci 114 15 min 10 322 25 min far target 90 laboratorybased rdt using plasma showed better sensitivity 46 3261 15 min 50 3664 25 min reach target sensitivity among 52 pcrpositive participants lassa fever positive rdt results associated lower cycle threshold values glycoprotein precursor gpc gene mean 303 sd 43 large l gene mean 323 37 vs gpc gene mean 245 39 l gene mean 280 36 personnel conducting bedside test procedure reported hindered inconvenient use full personal protective equipment long waiting procedures result could read panlassa rdt currently recommended diagnostic screening tool suspected lassa fever cases marked improvement sensitivity user friendliness needed rdt adopted clinically remains urgent need better lassa fever diagnostics promote safety inhospital care better disease outcomes lowresource settings mdecins sans frontires