Francesca Buttini, Stavroula Rozou, Alessandra Rossi, Varvara Zoumpliou, Dimitrios M Rekkas
The application of Quality by Design framework in the pharmaceutical development of dry powder inhalers
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
stability timing key daily routine behaviors workingdoing housework sleeping eating engaging social interactions ie behavioralsocial rhythms contributes health study examined whether behavioralsocial rhythms associated cardiovascular disease cvd risk factors retired night shift workers retired day workers explored whether past night shift work exposure moderated association total 154 retired older adults participated study multiple logistic regression models used examine associations behavioralsocial rhythms cvd risk factors independent variables included social rhythm metric srm5 score actigraphy restactivity rhythm intradaily variability iv interdaily stability dependent variables metabolic syndrome prevalence five individual components regular behavioralsocial rhythms associated lower odds prevalent metabolic syndrome srm odds ratio 057 95 confidence interval ci 035088 iv 400 95 ci 186858 042 95 ci 024073 two individual components body mass index srm 056 95 ci 037085 iv 284 95 ci 159507 042 95 ci 026068 highdensity lipoprotein cholesterol srm 049 95 ci 030080 iv 249 95 ci 125496 035 95 ci 019066 past shift work history moderate association behavioralsocial rhythms metabolic syndrome behavioralsocial rhythms related cvd risk factors retired adults regardless prior night shift work exposure older retired workers may benefit education interventions aiming increase behavioralsocial rhythm regularity