Rebecca L. Koscik|Sara E. Berman|Lindsay R. Clark|Kimberly D. Mueller|Ozioma C. Okonkwo|Carey E. Gleason|Bruce P. Hermann|Mark A. Sager|Sterling C. Johnson
Intraindividual Cognitive Variability in Middle Age Predicts Cognitive Impairment 8–10 Years Later: Results from the Wisconsin Registry for Alzheimer’s Prevention
University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|Geriatric Research Education and Clinical Center
abstract objectives intraindividual cognitive variability iicv shown differentiate groups normal cognition mild cognitive impairment mci dementia study examined whether baseline iicv predicted subsequent mild moderate cognitive impairment cognitively normal baseline sample methods participants 4 waves cognitive assessment drawn wisconsin registry alzheimers prevention wrap n 684 53666 baseline age 9110 years followup 70 female 746 parental history alzheimers disease primary outcome wave 4 cognitive status cognitively normal vs impaired determined consensus conference impaired included early mci n 109 clinical mci n 11 dementia n 1 primary predictors included two iicv variables based standard deviation set scores 6 factor iicv 4 test iicv iicv variable tested series logistic regression models determine whether iicv predicted cognitive status exploratory analyses distributionbased cutoffs incorporating memory executive function iicv patterns used create test mci risk variable results results similar iicv variables higher iicv associated greater risk subsequent impairment covariate adjustment adjusting memory executive functioning scores contributing iicv iicv significant mci risk variable also predicted risk impairment conclusions iicv middleage predicts subsequent impairment weaker risk indicator memory executive function scores contributing calculation exploratory analyses suggest potential incorporate iicv patterns risk assessment clinical settings jins 2016 22 10161025