Sonia L Rubens, Spencer C Evans, Stephen P Becker, Paula J Fite, Andrea M Tountas
Self-Reported Time in Bed and Sleep Quality in Association with Internalizing and Externalizing Symptoms in School-Age Youth
Child psychiatry and human development
several recent works using restingstate fmri suggest possible alterations restingstate functional connectivity mild traumatic brain injury however literature plagued various analysis approaches small study cohorts resulting inconsistent array reported findings study aimed investigate differences wholebrain restingstate functional connectivity adult patients mild traumatic brain injury within 1 month injury healthy control subjects using several comprehensive restingstate functional connectivity measurement methods analyses total 123 subjects 72 patients mild traumatic brain injury 51 healthy controls included standard fmri preprocessing pipeline used roiseedbased analyses conducted using 4 standard brain parcellation methods independent component analysis method applied measure restingstate functional connectivity fractional amplitude lowfrequency fluctuations also measured group comparisons performed measurements appropriate wholebrain multilevel statistical analysis correction significant differences age sex education hand preference groups well significant correlation measurements potential confounders found restingstate functional connectivity measurement revealed various regions connections different groups however corrected multiple comparisons results showed statistically significant differences groups terms restingstate functional connectivity across methods analyses although previous studies point multiple regions networks possible mild traumatic brain injury biomarkers study shows effect mild injury brain restingstate functional connectivity survived rigorous statistical correction study using subjectlevel connectivity analyses may necessary due subtle variable effects mild traumatic brain injury brain functional connectivity across individuals