Daniela Stadler, Constanze Helbig, Klaus Wuchner, Jürgen Frank, Klaus Richter, Andrea Hawe, Tim Menzen
Challenges in the analysis of pharmaceutical lentiviral vector products by orthogonal and complementary physical (nano)particle characterization techniques
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
evening chronotype known associated various chronic diseases cardiovascular risk factors metabolic syndrome group conditions together raise risk coronary heart disease diabetes stroke serious health problems studies published association chronotype metabolic syndrome unselected population data conflicting results aim study evaluate association chronotype metabolic syndrome population level using unselected northern finland birth cohort 1966 nfbc1966 database study population consists nfbc66 participants n5113 57 female age 46 years chronotype determined shortened morningnesseveningness questionnaires expressed morning 44 intermediate 44 evening types 12 metabolic syndrome determined according definition international diabetes federation oneway anova kruskalwallis test chisquared tests used compare chronotype groups followed logistic regression analysis adjusted alcohol consumption smoking marital status level education leisuretime physical activity women prevalence metabolic syndrome statistically significantly higher evening type group23 24 34 morning intermediate evening groups respectively p0001 logistic regression analysis evening chronotype associated higher risk metabolic syndrome 15 ci 95 12 20 populationbased birth cohort study evening chronotype independently associated higher prevalence metabolic syndrome women