Steven Wickens|Stephen C. Bowden|Wendyl D?Souza
Cognitive functioning in children with self?limited epilepsy with centrotemporal spikes: A systematic review and meta?analysis
University of Melbourne|St Vincent's Hospital|St Vincent's Hospital|University of Melbourne
well appreciated benign epilepsy centrotemporal spikes bects recently ects associated range cognitive behavioral disturbances despite improved understanding cognitive functioning ects date efforts quantitatively synthesize available literature within comprehensive cognitive frameworkthe present systematic review metaanalysis conducted according prisma guidelines fortytwo casecontrol samples met eligibility criteria comprising total 1237 children ects 1137 healthy control children univariate randomeffects metaanalyses conducted eight cognitive factors accordance cattellhorncarroll model intelligenceoverall children ects demonstrated significantly lower scores neuropsychological tests across cognitive factors compared healthy controls observed effects ranged 042 081 pooled standard deviation units largest effect longterm storage retrieval smallest effect visual processingthe results present metaanalysis provide first clear evidence children ects display profile pervasive cognitive difficulties thus challenge current conceptions ects benign disease limited specific localized cognitive effect