Marcello Tonelli|Natasha Wiebe|Bruce Guthrie|Matthew T. James|Hude Quan|Martin Fortin|Scott Klarenbach|Peter Sargious|Sharon E. Straus|Richard Lewanczuk|Paul E. Ronksley|Braden Manns|Brenda R. Hemmelgarn
Comorbidity as a driver of adverse outcomes in people with chronic kidney disease
University of Calgary|University of Alberta|University of Dundee|University of Calgary|University of Calgary|Université de Sherbrooke|University of Alberta|Alberta Health Services|University of Toronto|Alberta Health Services|University of Calgary|University of Calgary|University of Calgary
chronic kidney disease ckd associated poor outcomes perhaps due high burden comorbidity studies ckd populations focus concordant comorbidities cause ckd hypertension diabetes often accompany ckd heart failure coronary disease less known burden mental health conditions discordant conditions concordant still clinically relevant like dementia cancer retrospective populationbased cohort study 530771 adults ckd residing alberta canada 2003 2011 validated algorithms applied data provincial health ministry assess presenceabsence 29 chronic comorbidities linkage comorbidity burden adverse clinical outcomes mortality hospitalization myocardial infarction examined median followup 48 months comorbidities classified three categories concordant mental healthchronic pain discordant median number comorbidities 1 range 015 substantial proportion participants 3 5 comorbidities 25 7 respectively concordant comorbidities associated excess risk hospitalization discordant comorbidities mental health conditions thus discordant comorbidities mental health conditions well concordant comorbidities important independent drivers adverse outcomes associated ckd