Emily R Zier, W David Bradford
To attend or not to attend? The effect of school-immunization exemption policies on enrollment rates for prekindergarten, kindergarten and elementary aged youth
Vaccine
resistance cancers treatments chemotherapy largely arise due cell mutations mutations allow cells resist apoptosis inevitably lead recurrence often progression aggressive cancer forms sustainedlow dose therapies considered alternative maximum tolerated dose treatments whereby smaller drug dosage given longer period time however understanding impact presence treatmentresistant clones may new treatment modalities crucial validating therapeutic avenue study moran process used capture stochastic mutations arising cancer cells inferring treatment resistance model used predict probability cancer recurrence given varying treatment modalities simulations predict sustainedlow dose therapies would virtually ineffective cancer nonnegligible probability developing subclone resistance tendencies furthermore calibrating model vivo measurements breast cancer treatment herceptin model suggests standard treatment regimens ineffective mouse model using simple moran model possible explore likelihood treatment success given nonnegligible probability treatment resistant mutations suggest robust therapeutic schedules