Yuanjing Li, Mingqi Wang, Lin Cong, Tingting Hou, Lin Song, Xiang Wang, Lin Shi, Serhiy Dekhtyar, Yongxiang Wang, Yifeng Du, Chengxuan Qiu
Lifelong Cognitive Reserve, Imaging Markers of Brain Aging, and Cognitive Function in Dementia-Free Rural Older Adults: A Population-Based Study
Journal of Alzheimer's disease : JAD
earlyonset colorectal cancer eocrc defined diagnosis younger age 50 years increasing socalled red flag signs symptoms among individuals often missed leading diagnostic delays improved recognition presenting signs symptoms associated eocrc could facilitate timely diagnosis impact clinical outcomes report frequency presenting red flag signs symptoms among individuals eocrc examine association eocrc risk measure variation time diagnosis sign symptom presentation pubmedmedline embase cinahl web science searched database inception may 2023 studies reported sign symptom presentation time sign symptom presentation diagnosis patients younger age 50 years diagnosed nonhereditary crc included data extraction quality assessment performed independently duplicate included studies using preferred reporting items systematic reviews metaanalyses reporting guidelines joanna briggs institute critical appraisal tools used measure risk bias data frequency signs symptoms pooled using randomeffects model outcomes interest pooled proportions signs symptoms patients eocrc estimates association signs symptoms eocrc risk time sign symptom presentation eocrc diagnosis 12 859 unique articles initially retrieved 81 studies 24 908 126 patients younger 50 years included common presenting signs symptoms reported 78 included studies hematochezia pooled prevalence 45 95 ci 4050 abdominal pain pooled prevalence 40 95 ci 3545 altered bowel habits pooled prevalence 27 95 ci 2233 hematochezia estimate range 52540 abdominal pain estimate range 1360 anemia estimate range 21108 associated higher eocrc likelihood time signs symptoms presentation eocrc diagnosis mean range 64 18137 months 23 studies median range 4 2087 months 16 studies systematic review metaanalysis patients eocrc nearly half individuals presented hematochezia abdominal pain onequarter altered bowel habits hematochezia associated least 5fold increased eocrc risk delays diagnosis 4 6 months common findings highlight need identify concerning eocrc signs symptoms complete timely diagnostic workup particularly individuals without alternative diagnosis sign symptom resolution