Adla Bakri Hassan, Amgad El-Agroudy, Mohamed Hany Shehata, Maryam Abdulla Almoawda, Hani Salem Atwa
Adaptations of Clinical Teaching During the COVID-19 Pandemic: Perspectives of Medical Students and Faculty Members
Advances in medical education and practice
aim characterise indepth metabolic response aerobic exercise impact residual pancreatic beta cell function type 1 diabetes also aimed use metabolome distinguish individuals type 1 diabetes reduced maximal aerobic capacity exercise defined vo2peak thirty participants type 1 diabetes 3 years duration 30 control participants recruited groups differ age sex quantification peak stimulated cpeptide participants categorised undetectable 3 pmoll low 3200 pmoll high 200 pmoll residual beta cell function maximal aerobic capacity assessed vo2peak test differ control type 1 diabetes groups participants completed 45 min incline treadmill walking 60 vo2peak venous blood taken prior exercise immediately post exercise 60 min recovery serum analysed using targeted metabolomics metabolomic data analysed multivariate statistics define metabolic phenotype exercise type 1 diabetes receiver operating characteristic roc curves used identify circulating metabolomic markers maximal aerobic capacity vo2peak exercise health type 1 diabetes maximal aerobic capacity vo2peak inversely correlated hba1c type 1 diabetes group r2017 p0024 higher resting serum tricarboxylic acid cycle metabolites malic acid fold change 14 p0001 lactate fold change 122 p123105 differentiated people type 1 diabetes higher serum acylcarnitines ac ac c141 f value1225 p0001345 ac c12 f value11055 p00018 unique metabolic response exercise people type 1 diabetes cpeptide status differentially affected metabolic responses serum acs exercise ac c181 leverage 0066 squared prediction error 307 malic acidpyruvate ratio rested serum diagnostic maximal aerobic capacity vo2peak people type 1 diabetes roc curve auc 0867 95 ci 0716 0956 serum metabolome distinguishes high low maximal aerobic capacity diagnostic potential facilitating personalised medicine approaches manage aerobic exercise fitness type 1 diabetes