Carlos Blanco|Mark Olfson|Mayumi Okuda|Edward V. Nunes|Shang-Min Liu|Deborah S. Hasin
Generalizability of clinical trials for alcohol dependence to community samples
Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University
growing concern results tightly controlled clinical trials individuals alcohol use disorders may generalize broader community samples assess proportion communitydwelling adults alcohol dependence would eligible typical alcohol dependence treatment study developed new simple method applied standard set eligibility criteria commonly used alcohol outcome studies large n 43093 representative us adult sample interviewed facetoface national epidemiologic survey alcohol related conditions nesarc found approximately onehalf 505 individuals dsmiv diagnosis alcohol dependence n 1484 794 sought treatment n 185 excluded one study criteria individual study criteria excluded 09 482 overall sample 08 437 treatmentseeking sample overall sample lack motivationcompliance financial situation criteria excluded largest percentage individuals treatmentseeking subsample comorbid medical conditions legal problems excluded largest proportions individuals study provides new method assess generalizability clinical trials gives evidence typical clinical trials alcohol dependence likely exclude adults disorder community care support notion clinical trials recruit pure rather typical patients clinical trials carefully evaluate effects selected eligibility criteria generalizability results