Pu Shang|Gordon G. Liu|Xin Zheng|P. Michael Ho|Shuang Hu|Jing Li|Zihan Jiang|Xi Li|Xueke Bai|Yan Gao|Chao Xing|Yun Wang|Sharon?Lise T. Normand|Harlan M. Krumholz
Association Between Medication Adherence and 1?Year Major Cardiovascular Adverse Events After Acute Myocardial Infarction in China
China Pharmaceutical University|Chinese Academy of Medical Sciences & Peking Union Medical College|Peking University|China Pharmaceutical University|Chinese Academy of Medical Sciences & Peking Union Medical College|University of Colorado Denver|Chinese Academy of Medical Sciences & Peking Union Medical College|Chinese Academy of Medical Sciences & Peking Union Medical College|Chinese Academy of Medical Sciences & Peking Union Medical College|Peking Union Medical College Hospital|Chinese Academy of Medical Sciences & Peking Union Medical College|Chinese Academy of Medical Sciences & Peking Union Medical College|Chinese Academy of Medical Sciences & Peking Union Medical College|Chinese Academy of Medical Sciences & Peking Union Medical College|Harvard University|Yale New Haven Hospital|Harvard University|Yale University|Yale New Haven Hospital|Yale New Haven Health System
background secondary prevention acute myocardial infarction ami requires longterm guidelinedirected medical therapy however level medication adherence factors associated poor adherence extent good adherence reduce adverse events ami china remain uncertain methods results 2013 2014 4001 ami patients aged 18 years discharged alive 53 hospitals across china mean age 605117 years 227 female good adherence defined taking medications aspirin blockers statins clopidogrel angiotensinconverting enzyme inhibitorsangiotensinreceptor blockers 90 time prescribed cox models assessed association good adherence timevarying covariate 1year cardiovascular events ami common medications aspirin 822 statins 805 243 patients prescribed medications followup 1year event rates higher patients 251 95 ci 197306 versus taking 1 medications 66 95 ci 576734 overall rate good adherence 529 good adherence associated lower risk 1year events adjusted hazard ratio 061 95 ci 049077 common reason poor adherence belief ones condition improvedno longer required medication comorbidities lower education level associated poor adherence conclusions good adherence reduced 1year cardiovascular event risk ami half cohort good adherence national efforts improve ami outcomes china focus medication adherence educating patients importance cardiovascular medications reducing risk recurrent events clinical trial registration url httpwwwclinicaltrialsgov unique identifier nct01624909