Annachiara Marra|Pratik P. Pandharipande|Timothy D. Girard|Mayur B. Patel|Christopher G. Hughes|James C. Jackson|Jennifer L. Thompson|Rameela Chandrasekhar|E. Wesley Ely|Nathan E. Brummel
Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness*
Vanderbilt University Medical Center|University of Naples Federico II|Vanderbilt University Medical Center|University of Pittsburgh|Vanderbilt University Medical Center|Vanderbilt University Medical Center|Vanderbilt University Medical Center|VA Tennessee Valley Healthcare System|Vanderbilt University|Vanderbilt University|Vanderbilt University Medical Center|Geriatric Research Education and Clinical Center|Vanderbilt University Medical Center
objectives describe frequency cooccurring newly acquired cognitive impairment disability activities daily livings depression among survivors critical illness evaluate predictors free postintensive care syndrome problems design prospective cohort study setting medical surgical icus five us centers patients patients respiratory failure shock excluding preexisting cognitive impairment disability activities daily livings interventions none measurements main results 3 12 months hospital discharge assessed patients cognitive impairment disability depression categorized patients eight groups reflecting combinations cognitive disability mental health problems using multivariable logistic regression modeled association age education frailty durations mechanical ventilation delirium severe sepsis odds postintensive care syndrome free analyzed 406 patients median age 61 years acute physiology chronic health evaluation ii 23 3 12 months one postintensive care syndrome problems present 64 56 respectively nevertheless cooccurring postintensive care syndrome problems ie two domains present 25 3 months 21 12 months postintensive care syndrome problems three domains present 6 3 months 4 12 months years education associated greater odds postintensive care syndrome free p lt 0001 3 12 mo severe frailty associated lower odds postintensive care syndrome free p 0005 3 mo p 0048 12 mo conclusions multicenter cohort study one postintensive care syndrome problems present majority survivors cooccurring problems present one four education protective postintensive care syndrome problems frailty predictive development postintensive care syndrome problems future studies needed understand better heterogeneous subtypes postintensive care syndrome identify modifiable risk factors