Christine Graham, Ayanda Gina, Janet Seeley, Yougan Saman
Development of a questionnaire to assess mothers' knowledge, attitudes and practice with regard to childhood hearing loss and Universal Newborn Hearing Screening
International journal of pediatric otorhinolaryngology
adaptive stress response pathways srps restore cellular homeostasis following perturbation may activate terminal outcomes like apoptosis autophagy cellular senescence disruption exceeds critical thresholds srps hold key vital cellular tipping points targeted therapeutic interventions assessed biomarkers toxicity hence developing public database chemicals perturb srps enable new datadriven tools improve public health report automated textmining pipeline used build curate first version database started 100 reference srp chemicals gathered published biomarker studies bootstrap database second used information retrieval find cooccurrences reference chemicals srp terms pubmed abstracts determined pairwise mutual information thresholds filter biologically relevant relationships third applied thresholds find 1206 putative srp perturbagens within thousands substances library integrated networkbased cellular signatures lincs assign srp activity lincs chemicals domain experts manually review least three publications 1206 chemicals 181805 total abstracts accomplish efficiently implemented machine learning approach predict srp classifications texts prioritize abstracts 5fold crossvalidation testing corpus derived 100 reference chemicals artificial neural networks performed best f1macro 0678 prioritized 2479181805 abstracts expert review resulted 457 chemicals annotated srp activities independent analysis enriched mechanisms action chemical use class supported textmined chemical associations p 005 heat shock inducers linked hsp90 dna damage inducers topoisomerase inhibition database enable novel applications lincs data evaluate srp activities develop tools biomedical information extraction literature