Magnus Ö. Ulfarsson|G. Bragi Walters|Ómar Gústafsson|Stacy Steinberg|Ana Isabel Silva|Orla Doyle|Michael Brammer|Daníel F. Guðbjartsson|Sunna Arnarsdóttir|Guðrún A. Jónsdóttir|Rósa S. Gísladóttir|Gyða Björnsdóttir|Hannes Helgason|Lotta M. Ellingsen|Jónas G. Halldórsson|Evald Sæmundsen|Berglind Stefánsdóttir|Lina Jönsson|Valgerdur Kristin Eiriksdottir|Guðný Eiríksdóttir|G H Johannesdottir|Unnur Unnsteinsdóttir|Birna Jónsdóttir|Brynja B. Magnúsdóttir|Patrick Sulem|U. Thorsteinsdottir|Engilbert Sigurðsson|Daniel Brandeis|Andreas Meyer?Lindenberg|Hreinn Stefánsson|Kári Stéfansson
15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia
deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|Cardiff University|King's College London|King's College London|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|University of Iceland|University of Iceland|University of Iceland|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|National University Hospital of Iceland|deCODE Genetics (Iceland)|deCODE Genetics (Iceland)|National University Hospital of Iceland|University of Zurich|Central Institute of Mental Health|University Hospital Heidelberg|Heidelberg University|deCODE Genetics (Iceland)|University of Iceland
abstract several copy number variants associated neuropsychiatric disorders variants shown also influence cognitive abilities carriers unaffected psychiatric disorders previously associated 15q112bp1bp2 deletion specific learning disabilities larger corpus callosum investigate much larger sample effect 15q112bp1bp2 deletion cognitive structural functional correlates dyslexia dyscalculia report deletion confers greatest risk combined phenotype dyslexia dyscalculia also show deletion associates smaller left fusiform gyrus moreover tailored functional magnetic resonance imaging experiments using phonological lexical decision multiplication verification tasks demonstrate altered activation left fusiform left angular gyri carriers thus using convergent evidence neuropsychological testing structural functional neuroimaging show 15q112bp1bp2 deletion affects cognitive structural functional correlates dyslexia dyscalculia