Vanderlan O Batista|Michael Kellner|Roberto Salvatori|Walter Lisboa Oliveira|André Faro|L Santos|Enaldo Vieira de Melo|Alécia A Oliveira-Santos|Carla R. P. Oliveira|Viviane C. Campos|Cynthia S. Barros-Oliveira|Elenilde G. Santos|Nathalie Oliveira de Santana|Keila R Villar-Gouy|Ângela C. Leal|Rivia S Amorim|Diana Simões|Manuel H. Aguiar?Oliveira
Cognitive performance during senescence in untreated congenital isolated GH deficiency
Universidade Federal de Sergipe|Technical University of Munich|Universität Hamburg|University Medical Center Hamburg-Eppendorf|Johns Hopkins Medicine|Johns Hopkins University|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe|Universidade Federal de Sergipe
individuals untreated isolated gh deficiency ighd due mutation ghrh receptor gene itabaianinha brazil increased insulin sensitivity normal life expectancy extended health span ie period life free disabilities hypothesize prolonged health span accompanied delayed cognitive decline senescence test hypothesis administered literacyindependent cognitive assessment lica 15 ighd individuals aged 50 years 15 controls matched age sex years education percentage illiteracy individuals negative hiv syphilis serology differences serum levels folate vitamin b12 tsh two groups free t4 higher ighd group ighd subjects higher total lica score controls 215 227 vs 2042 181 without reaching statistical significance scores memory visuoconstruction language calculation similar two groups better attention 95 14 vs 83 11 p 001 executive function 383 48 vs 351 25 p 003 scores ighd mancova revealed group age significant effect lica variables partial eta squared 0455 power 0812 p 002 effect verified attention partial eta squared 0216 power 0749 p 001 executive function partial eta squared 0154 power 0570 p 003 conclusion ighd senescence associated similar total cognitive performance better attention executive function controls