Monirah Albloushi, Aisha Namshan Aldawsari, Reem Alghamdi, Badr Alenazy, Hana Alanazi, Hissah Almutairi
Nurse Educator's experiences and challenges with online teaching: A qualitative descriptive study
Heliyon
although observational studies found positive negative association depression hypercholesterolemia findings mixed contradictory knowledge first study employs bidirectional mendelian randomization mr multivariable mr analysis extensive genomewide association studies gwas data examine causal effect depression hypercholesterolemia using summary statistics obtained gwas individuals european ancestry utilize bidirectional 2sample mr approach explore potential causal association hypercholesterolemia depressive symptoms multivariable mendelian randomization analysis used examine whether direct causal effect depression risk hypercholesterolemia affected traits associated increased risk hypercholesterolemia mr analysis utilized inverse variance weighted ivw mregger regression weighted mode weighted median methods data summary level depression acquired gwas involved 500199 participants used summary gwas datasets hypercholesterolemia including 206067 participants also used another gwas databases hypercholesterolemiat n 463010 validate results utilizing ivw discovered possibility 31 rise risk hypercholesterolemia due depression 131 95 ci 110157 p 002 found consistent causal effect depression hypercholesterolemia ivw analyses using different hypercholesterolemia datasets adjustment smoking physical activity obesity remains significant causal relationship depression hypercholesterolemia 125 95 ci 101154 p 040 however find evidence indicating hypercholesterolemia leads depression opposite direction directional pleiotropy observed mregger regression analysis additionally mrpresso analysis validated discoveries neither leaveoneout sensitivity test funnel plots revealed outliers unadjusted adjusted estimates depression consistent direct causal effect hypercholesterolemia study led improved comprehension causal connections hypercholesterolemia depression could aid prevention treatment hypercholesterolemia