Bonnie Y Ohye, Rafaella J Jakubovic, Rebecca Zakarian, Eric Bui
Staying Strong with Schools: Testing an Elementary School-Based Intervention for Military-Connected Children
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
sarscov2 employs spike proteins receptor binding domain rbd enter host cells rbd constantly subjected immune responses requiring efficient binding host cell receptors successful infection however understanding rbds biophysical properties contribute sarscov2s epidemiological fitness remains largely incomplete comprehensive approach comprising largescale sequence analysis sarscov2 variants identification fitness function based binding thermodynamics unravel relationship biophysical properties rbd variants contribution viral fitness developed biophysical model uses statistical mechanics map molecular phenotype space characterized dissociation constants rbd ace2 lycov016 lycov555 regn10987 s309 onto epistatic fitness landscape validate findings experimentally measured machine learning ml estimated binding affinities coupled infectivity data derived populationlevel sequencing analysis reveals model effectively predicts fitness novel rbd variants account epistatic interactions among mutations including explaining later reversal q493r study sheds light impact specific mutations viral fitness delivers tool predicting future epidemiological trajectory previously unseen emerging lowfrequency variants insights offer greater understanding viral evolution also potentially aid guiding public health decisions battle covid19 future pandemics