Ayal A. Aizer|Tyler J. Wilhite|Ming?Hui Chen|Powell L. Graham|Toni K. Choueiri|Karen E. Hoffman|Neil E. Martin|Quoc?Dien Trinh|Jim C. Hu|Paul L. Nguyen
Lack of reduction in racial disparities in cancer?specific mortality over a 20?year period
Zero to Three|Harvard University|Zero to Three|Harvard University|University of Connecticut|Dana-Farber Brigham Cancer Center|Brigham and Women's Hospital|Dana-Farber Cancer Institute|Dana-Farber Brigham Cancer Center|Brigham and Women's Hospital|Harvard University|Dana-Farber Cancer Institute|The University of Texas MD Anderson Cancer Center|Dana-Farber Brigham Cancer Center|Brigham and Women's Hospital|Dana-Farber Cancer Institute|Brigham and Women's Hospital|University of California, Los Angeles|Dana-Farber Brigham Cancer Center|Brigham and Women's Hospital|Dana-Farber Cancer Institute
authors knowledge remains unknown whether racebased differences cancer outcomes changed time current study authors assessed whether racial disparities cancerspecific mortality improved last 20 yearsthe surveillance epidemiology end results program used identify 2713474 patients diagnosed 1988 2007 either lung breast prostate colorectal cancer leading 3 causes cancerrelated mortality among sex exclusions 1001978 patients remained eligible analysis impact race cancerspecific mortality assessed using regression model fine gray interaction model evaluated trends timeafrican americans presented advanced stage disease p 001 underwent definitive therapy less often p 001 whites adjustment demographics year diagnosis african americans found higher estimates cancerspecific mortality whites cancers combined hazards ratio 128 95 confidence interval 126130 p 001 within individual cancer p 05 differences change significantly 1988 1997 1998 2007 except among patients breast cancer survival disparities increased findings remained significant adjustment stage disease presentation receipt definitive therapy hazards ratio breast cancer mortality african americans vs whites 137 19881997 153 19982007 p interaction 001the survival gap african americans closed time racebased differences outcome persist independent stage disease treatment suggesting additional strategies beyond screening improving access care research tumor biologies disproportionately affecting african americans needed improve survival african american patients cancer