Jinhong Zhao, Bing-Long Wang, Xiaoping Qin, Yuanli Liu, Tingfang Liu
Core Elements of Excellent Hospital Leadership: Lessons from the 5 Top-performing Hospitals in China
International journal for quality in health care : journal of the International Society for Quality in Health Care
address limitations alginate gelatin separate hydrogels partially oxidized alginate alginate dialdehyde ada usually combined gelatin prepare adagel hydrogels hydrogels offer tunable properties controllable degradation suitable stiffness 3d bioprinting tissue engineering applications several processing variables affect final properties hydrogel including degree oxidation gelatin content type crosslinking agent addition 3dprinted structures pore size possible addition filler make hydrogel composite also affect final physical biological properties study utilized datasets 13 research papers encompassing 33 unique combinations ada concentration gelatin concentration cacl2 microbial transglutaminase mtg concentrations crosslinkers pore size bioactive glass bg filler content one identified target property hydrogels stiffness utilizing extreme boost xgb machine learning algorithm create predictive model understanding combined influence parameters hydrogel stiffness stiffness adagel hydrogels notably affected ada gel ratio higher gelatin content different ada gel concentrations weakens scaffold likely due presence unbound gelatin pore size inclusion bg particulate filler also significant impact stiffness smaller pore sizes higher bg content lead increased stiffness optimization adagel composition inclusion bg fillers key determinants tailor stiffness 3d printed hydrogels found analysis available data