David J. Hyman|Kalu I. Ogbonnaya|Addison Taylor|K.L. Ho|Valory Pavlik
Ethnic differences in nocturnal blood pressure decline in treated hypertensives
Baylor College of Medicine|Baylor College of Medicine|Baylor College of Medicine|Baylor College of Medicine|Baylor College of Medicine
lack nocturnal decline blood pressure bp associated severe end organ damage hypertensives blacks appear less likely whites 10 drop nighttime bp dipping little information available relationship treatment regimens ethnic group classification dipping treated hypertensive patient populations obtained 24h ambulatory bp readings 438 adult white n 103 black n 200 hispanic n 135 treated hypertensives tycos monitors connected patients homes usual morning medication dose time research assistants administered qualityoflife questionnaire recorded patients drug regimen observed patients take morning dose monitors programmed record bp every 30 min dippers defined persons drop 10 decline average daytime 0800 2200 compared nighttime 0000 0400 bp logistic regression modeling used assess relationship demographic treatment variables probability dipping twentyfourhour average bp similar three ethnic groups however absence systolic dip significantly common black hispanic men white men black v white 1154 95 ci 392 3401 hispanic v white 732 95 ci 247 2168 ethnic group differences probability systolic dipping among women absence diastolic dip approximately twice common blacks hispanics whites marked genderbyethnicgroup interaction magnitude association 10 commonly prescribed antihypertensives single drug positively associated nocturnal bp decline later versus earlier morning dose time onceaday dosing associated absence dipping treated black hispanic hypertensives less likely dip nonhispanic whites particular drug positively associated dipping