Epco Hasker, Younoussa Assoumani, Andriamira Randrianantoandro, Stéphanie Ramboarina, Sofie Marijke Braet, Bertrand Cauchoix, Abdallah Baco, Aboubacar Mzembaba, Zahara Salim, Mohammed Amidy, Saverio Grillone, Nissad Attoumani, Sillahi Halifa Grillone, Maya Ronse, Koen Peeters Grietens, Mala Rakoto-Andrianarivelo, Hanitra Harinjatovo, Philip Supply, Rian Snijders, Carolien Hoof, Achilleas Tsoumanis, Philip Suffys, Tahinamandranto Rasamoelina, Paul Corstjens, Nimer Ortuno-Gutierrez, Annemieke Geluk, Emmanuelle Cambau, Bouke Catharina de Jong
Post-exposure prophylaxis in leprosy (PEOPLE): a cluster randomised trial
The Lancet. Global health
extant research indicates children adolescents autism spectrum disorder asd without intellectual disability id often experience difficulty comprehending written texts unexpected comparison cognitive abilities study investigated development two key skills narrative inference abilities support higher level text comprehension relation lexicalsemantic knowledge asd symptomatology age three questions addressed 1 nature narrative inference skill development time 2 relation narrative inference development lexicalsemantic knowledge asd symptomatology age 3 initial narrative inferencing skills development skills predict reading comprehension outcomes methods data 81 children adolescents asd without id fiq 75 ages 816yearsold timepoint 1 collected 15month intervals across three timepoints asd symptomatology assessed ados2 standardized narrative retelling inference reading comprehension lexicalsemantic knowledge cognitive assessments administered latent growth curve models conducted examine narrative inference skill development conditional growth models fit examine relation growth trajectories covariates lexicalsemantic knowledge asd symptomatology age well reading comprehension distal outcome narrative retelling skills followed linear trajectory growth relative strength sample inference skills well average declined time relative agenormed standard scores lexicalsemantic knowledge explained significant heterogeneity initial narrative inference skills whereas asd symptomatology related initial narrative retelling abilities age related initial inference abilities timepoint 3 reading comprehension skill average range significantly explained initial narrative retelling inference abilities results study indicate narrative retelling inference skills important successful reading comprehension individuals asd without id lexicalsemantic knowledge underpins skills furthermore observation asd symptom severity associated narrative retelling skills consistent hypothesis problems narrative reading skills associated autism phenotype finally inference skill particular challenge individuals sample although age positively associated better performance assessmentimplications findings suggest narrative inference skills addition lexicalsemantic knowledge important target beginning elementary grades improve reading comprehension outcomes children adolescents asd without id