Andrés Cárdenas|Devin C. Koestler|E. Andrés Houseman|Brian P. Jackson|Molly L. Kile|Margaret R. Karagas|Carmen J. Marsit
Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic<i>in utero</i>
Corvallis Environmental Center|Health and Human Development (2HD) Research Network|Oregon State University|University of Kansas Medical Center|Corvallis Environmental Center|Health and Human Development (2HD) Research Network|Oregon State University|Dartmouth College|Corvallis Environmental Center|Health and Human Development (2HD) Research Network|Oregon State University|Dartmouth College|Hanover College|Dartmouth College
mercury arsenic known developmental toxicants prenatal exposures associated adverse childhood health outcomes could part mediated epigenetic alterations may also contribute altered immune profiles study examined association prenatal mercury exposure dna methylation white blood cell composition cord blood evaluated interaction prenatal arsenic exposure total 138 motherinfant pairs postpartum maternal toenail mercury prenatal urinary arsenic concentrations newborn cord blood assessed using illumina infinium methylation450 array white blood cell composition inferred dna methylation measurements doubling toenail mercury concentration associated 25 decrease 95 ci 50 10 estimated monocyte proportion increase 35 95 ci 10 70 bcell proportion observed females among top 100 cpgs associated toenail mercury levels ranked pvalue significant enrichment loci located north shore regions cpg islands p 0049 majority loci hypermethylated 85 among top 100 cpgs interaction arsenic mercury greater expected proportion loci located cpg islands p 0045 south shore regions p 0009 loci hypermethylated work supports hypothesis mercury may contributing epigenetic variability immune cell proportion changes suggests utero exposure mercury arsenic even low levels may interact impact epigenome