Suk Hwan Kim, Jiho Lee, Inbo Oh, Yeonsuh Oh, Chang Sun Sim, Jin-Hee Bang, Jungsun Park, Yangho Kim
Allergic rhinitis is associated with atmospheric SO2: Follow-up study of children from elementary schools in Ulsan, Korea
PloS one
widespread use highthroughput sequencing techniques leading rapidly increasing number diseaseassociated variants unknown significance candidate genes integration knowledge concerning genetic protein well functional conservational aspects necessary exhaustive assessment relevance prioritization clinical functional studies investigating role human disease collect necessary information multitude different databases accessed data extraction original sources commonly userfriendly requires advanced bioinformatics skills leads decreased data accessibility relevant number potential users clinicians geneticist clinical researchers present argus httpsargusurzuniheidelbergde standalone webtool simple extraction intuitive visualization multilayered gene protein variant variant effect prediction data argus provides interactive exploitation data within seconds known gene human genome contrast existing online platforms compilation variant data argus complements visualization chromosomal exonintron structure protein domain annotation clinvar gnomad variant distributions well positionspecific variant effect prediction score modeling argus thereby enables timely assessment protein regions vulnerable variation single amino acid resolution provides numerous applications variant protein domain interpretation well design vitro experiments