Kentaro Oniki|Junji Saruwatari|Tomoko Izuka|Ayami Kajiwara|Kazunori Morita|Misaki Sakata|Koji Otake|Yasuhiro Ogata|Kazuko Nakagawa
Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects
Kumamoto University|Kumamoto University|Kumamoto University|Kumamoto University|Kumamoto University|Kumamoto University|Japanese Red Cross Kumamoto Hospital|Japanese Red Cross Kumamoto Hospital|Kumamoto University
normal weight subjects body mass index 25 kgm2 nonalcoholic fatty liver disease nafld likely coexist metabolic diseases patatinlike phospholipase 3 pnpla3 polymorphism rs738409 c444cg associated risk nafld andor renal dysfunction however influence weight status associations remains unknown aimed clarify associations pnpla3 polymorphism risk nafld andor renal dysfunction also paying careful attention weight status subjects crosssectional retrospective longitudinal studies 55 11 years followup conducted 740 393 japanese participants 612 105 675 60 years respectively health screening program among 591 subjects habitual alcohol intake andor hepatitis b c virus infections pnpla3 gg genotype associated risk nafld normal weight subjects odds ratio 95 ci 306 111843 p 005 among subjects carriers pnpla3 gg genotype normal weight lower egfr cc genotype partial regression coefficient se 326 148 p 005 associations replicated longitudinal analyses among overweight subjects none genotypes significantly associated crosssectional longitudinal analyses however power analyses small especially analyses among overweight subjects findings study suggest carriers pnpla3 gg genotype normal weight status nevertheless carefully monitored presence nafld andor renal dysfunction