Karl G Hill, Jennifer A Bailey, Christine M Steeger, J David Hawkins, Richard F Catalano, Rick Kosterman, Marina Epstein, Robert D Abbott
Outcomes of Childhood Preventive Intervention Across 2 Generations: A Nonrandomized Controlled Trial
JAMA pediatrics
pulmonary atresia intact ventricular septum paivs rare cardiac congenital lesion characterized imperforate pulmonary valve intact ventricular septum atrial level shunt although different management strategies establish source nonductal dependent pulmonary blood flow described studies assessed relationship therapeutic approach patient characteristics outcomes purpose study identify predictors mortality patients paivs neonates children paivs identified analysis 2012 kids inpatient database healthcare cost utilization project hospital admissions included cardiac catheterization andor surgical procedure analyzed identify demographics comorbidities outcomes identified 508 patients paivs hospital admissions included cardiac catheterization n 165 surgical procedures n 273 n 70 incidence mortality cohort 669 34508 univariable analysis demonstrated age less 12 months p 0001 nonelective admission p 0001 aki p 0001 sepsis p 0002 use ecmo p 0001 associated increased risk mortality difference observed type therapeutic approach p 0498 variables used multivariable logistic regression analysis develop predictive model mortality age less 12 months nonelective admission use ecmo children paivs predictors mortality interestingly type therapeutic approach influence mortality suggests patient characteristics method chosen provide pulmonary blood flow determine mortality