Gudrun Rohde, Sølvi Helseth, Milada Hagen, Hilde Timenes Mikkelsen, Siv Skarstein, Kristin Haraldstad
The relationship between gender, psychosocial factors, pain, health literacy and health-related quality of life in parents of Norwegian adolescents one year into the COVID-19 pandemic
BMC public health
integrated approach based qbd pat provides systematic innovative framework product development manufacturing quality risk management context significance outcome design experiments selection product design robust commercial manufacturing process design space overall control strategy remains vital success drug product throughout life cycle paper aims discussing selected recent doe case studies conducted qbdbased integrated qbdpatbased development solid oral formulations process improvement studies main focus paper highlight rationales importance design selection development applications mathematical models statistical tools analyzing doe pat data developing design space control strategy improved process monitoring total 25 case studies includes 9 pat application studies discussed paper cover 11 manufacturing processes commonly utilized solid dosage forms two case studies relevant selection packaging design solid dosage forms also briefly discussed complete scope overall successful modern qbd approach highly important conducted analyzed logical sequence involves designs phaseappropriate qualitydriven facilitate statistical chemometric thinking development stage approach result higher regulatory flexibility along lower economic burden life cycle product irrespective regulatory path used nda anda