Juliana Dos Santos Müller, Ila Rocha Falcão, Maria Carolina Barreto Moreira Couto, Wendel da Silva Viana, Ivone Batista Alves, Denise Nunes Viola, Courtney Georgette Woods, Rita Franco Rêgo
Health-Related Quality of Life among Artisanal Fisherwomen/Shellfish Gatherers: Lower than the General Population
International journal of environmental research and public health
study neurotransmitter status children early epileptic developmental epileptic encephalopathy dee explore clinical response dopaminergic serotoninergic therapies group patients two hundred five patients 111 males 541 94 females 459 mean age 10 months onset epilepsy sd 1 year 1 month range 03 year epileptic encephalopathydee recruited including west syndrome ohtahara syndrome early myoclonic encephalopathy epilepsy infancy migrating focal seizures myoclonic encephalopathy nonprogressive disorders infantile spasms doose syndrome lennoxgastaut syndrome landaukleffner syndrome unclassified cerebrospinal fluid csf neurotransmitter studies patients medical records reviewed additionally present clinical data 10 patients low csf neurotransmitter levels received dopaminergicserotoninergic treatments abnormal neurotransmitter values identified 68 33 patients 5hydroxyindoleacetic acid 5hiaa deficit prevalent alteration 91 low csf 5hiaa levels significantly higher 1 3yearold children negative significant correlation found 5hiaa levels epilepsy duration csf study spearmans 0191 p0007 abnormalities deep grey matter associated low levels csf homovanillic acid 5hiaa ten patients low csf neurotransmitter levels received dopamine andor serotonin therapies six showed initial decrease seizure frequency severity maintained improvement neurodevelopmental skills considerable number patients showed neurotransmitter abnormalities age seizure onset duration epilepsy csf study principal factors related neurotransmitter depletion early monoamine supplementation would seem advisable neuroprotective strategy 5hydroxyindoleacetic acid homeostasis especially vulnerable patients epileptic encephalopathydevelopmental epileptic encephalopathy age seizure onset duration epilepsy determinants neurotransmitter depletion