Zeleke Dutamo Agde, Jeanette H Magnus, Nega Assefa, Muluemebet Abera Wordofa
The protocol for a cluster randomized controlled trial to evaluate couple-based violence prevention education and its ability to reduce intimate partner violence during pregnancy in Southwest Ethiopia
PloS one
mini mental state examination mmse cognitive test commonly used part evaluation possible dementiato determine diagnostic accuracy minimental state examination mmse various cut points dementia people aged 65 years community primary care settings undergone prior testing dementiawe searched specialised register cochrane dementia cognitive improvement group medline ovidsp embase ovidsp psycinfo ovidsp lilacs bireme alois biosis previews thomson reuters web science web science core collection including science citation index conference proceedings citation index thomson reuters web science also searched specialised sources diagnostic test accuracy studies reviews medion universities maastricht leuven wwwmediondatabasenl dare database abstracts reviews effects via cochrane library hta database health technology assessment database via cochrane library arif university birmingham uk wwwarifbhamacuk attempted locate possibly relevant unpublished data contacting researchers field first performed searches november 2012 fully updated may 2014 apply language date restrictions electronic searches use methodological filters method restrict search overallwe included studies compared 11item maximum score 30 mmse test cut point people undergone prior testing versus commonly accepted clinical reference standard allcause dementia subtypes alzheimer disease dementia lewy body dementia vascular dementia frontotemporal dementia clinical diagnosis included allcause unspecified dementia defined version diagnostic statistical manual mental disorders dsm international classification diseases icd clinical dementia ratingat least three authors screened citationstwo authors handled data extraction quality assessment performed metaanalysis using hierarchical summary receiveroperator curves hsroc method bivariate methodwe retrieved 24310 citations removal duplicates reviewed full text 317 fulltext articles finally included 70 records referring 48 studies synthesis able perform metaanalysis 28 studies community setting 44 articles 6 studies primary care 8 articles could extract usable 2 x 2 data remaining 14 community studies include metaanalysis studies community asymptomatic people whereas two six studies primary care conducted people symptoms possible dementia judged two studies high risk bias patient selection domain three studies high risk bias index test domain nine studies high risk bias regarding flow timing assessed studies applicable review question though concerns selection participants six studies target condition one studythe accuracy mmse diagnosing dementia reported 18 cut points community mmse score 10 1430 inclusive 10 cut points primary care mmse score 1726 inclusive total number participants studies included metaanalyses ranged 37 2727 median 314 interquartile range iqr 160 647 community pooled accuracy cut point 24 15 studies sensitivity 085 95 confidence interval ci 074 092 specificity 090 95 ci 082 095 cut point 25 10 studies sensitivity 087 95 ci 078 093 specificity 082 95 ci 065 092 seven studies adjusted accuracy estimates level education sensitivity 097 95 ci 083 100 specificity 070 95 ci 050 085 insufficient data evaluate accuracy mmse diagnosing dementia subtypeswe could estimate summary diagnostic accuracy primary care due insufficient datathe mmse contributes diagnosis dementia low prevalence settings used isolation confirm exclude disease recommend future work evaluates diagnostic accuracy tests context diagnostic pathway experienced patient investigators report undergoing mmse changes patientrelevant outcomes