W T Butler, W A Thomson, C T Morrissey, L M Miller, Q W Smith
Baylor's program to attract minority students and others to science and medicine
Academic medicine : journal of the Association of American Medical Colleges
study aimed investigate association irritable bowel syndrome ibs parkinsons disease pd utilizing prospective cohort study mendelian randomization dataset contained substantial cohort 426911 participants uk biobank discussing association ibs pd cox proportional hazards models casecontrol analysis adjusting covariates age gender ethnicity education level univariate cox regression model risk pd reduced ibs patients hr 0774 95ci 06250956 p 0017 statistical significance diminished three models adjusting variables subgroup analyses ibs patients less likely develop pd patients diagnosed ibs 2000 also lower risk hr 0633 95ci 04030994 p 0047 subsequently developing pd addition matched five healthy control participants based gender age end study ibs patient diagnosed followup period logistic regression results or1239 95ci 08961680 p 0181 showed ibs associated risk pd mendelian randomization find significant evidence causal relationship ibs parkinsons disease 0801 95ci 05701278 p 0204 overall suggest ibs status associated risk developing pd findings provide valuable insights clinical management resource allocation patients ibs