Yuhan Luo, Chi Young Oh, Beth St Jean, Eun Kyoung Choe
Interrelationships Between Patients' Data Tracking Practices, Data Sharing Practices, and Health Literacy: Onsite Survey Study
Journal of medical Internet research
1 inferred network provide good predictions relative experimental data 2 network inference algorithm applied within certain network model framework yield networks accurate relative criterion goodness first issue concerns scientific validation second concerns algorithm validation paper consider inferential validation relative controllability inference procedure applied data generated gene regulatory network intervention procedure designed inferred network well perform true network reasoning behind criterion purpose use gene regulatory networks design therapeutic intervention strategies concerned network fidelity per se ability design effective interventions based inferred network consider problem perspectives stationary control involves designing control policy applied time based current state network decision procedure time independent objective control policy optimally reduce total steadystate probability mass undesirable states phenotypes equivalent optimally increasing total steadystate mass desirable states based criterion compare several proposed network inference procedures see inference procedure may perform poorer inference procedure relative inferring full network structure perform better relative controllability hence one aiming specific application may wise use objectivebased measure inference validity