Brandon A. Kohrt|Carol M. Worthman|Kerry J. Ressler|Kristina B. Mercer|Nawaraj Upadhaya|Soniya Koirala|M K Nepal|V. D. Sharma|Elisabeth B. Binder
Cross-cultural gene? environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response:<b><i>FKBP5</i></b>polymorphisms and childhood trauma in South Asia
Duke Institute for Health Innovation|Duke University|Emory University|Emory University|Howard Hughes Medical Institute|Emory University|HealthNet TPO|Tribhuvan University Teaching Hospital|Tribhuvan University Teaching Hospital|Emory University|Max Planck Institute of Psychiatry
despite increased attention global mental health psychiatric genetic research dominated studies highincome countries especially populations european descent objective study assess single nucleotide polymorphisms snps fkbp5 gene population living south asia among adults nepal depression assessed beck depression inventory bdi posttraumatic stress disorder ptsd ptsd checklistcivilian version pclc childhood maltreatment childhood trauma questionnaire ctq fkbp5 snps genotyped 682 participants cortisol awakening response car assessed subsample 118 participants 3 days fkbp5 tagsnp rs9296158 showed main effect depressive symptoms p 003 interaction rs9296158 childhood maltreatment predicted adult depressive symptoms p 002 ptsd childhood maltreatment associated endocrine response individuals homozygous allele demonstrated negative car overall hypocortisolaemia rs9296158 aa genotype childhood maltreatment group p 0001 study replicated findings related fkbp5 depression ptsd geneenvironment studies take differences prevalence cultural significance phenotypes exposures account interpreting crosscultural findings