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vaccination programs rolled across globe contain mitigate spread covid19 infection recently programs limited adults older population thereby limiting children getting vaccinated recently malaysian government rolled vaccination children aged 511 years however certain factors might affect vaccination uptake among children study explores factors influencing parents hesitancy vaccinate children malaysia nationwide online crosssectional convenience sampling survey april 21 2022 june 3 2022 conducted study used descriptive statistics inform vaccine hesitancy among parents crosstabulation performed calculate frequency percentage vaccine hesitancy quality life ehealth literacy 5c psychological antecedents vaccination among parents children 511 years malaysia graphical methods used portray levels ehealth literacy levels 5c psychological antecedents vaccination study used bivariate multivariate analysis understand relationship vaccine hesitancy sociodemoeconomic factors quality life ehealth literacy 5c psychological antecedents 382 participants almost onethird 33 participants reported vaccine hesitancy children 5cs psychological antecedents vaccination around one quarter 2696 reported disagreement confidence vaccination almost half 5236 reported disagreement vaccination complacency threefifths 6099 reported vaccination constraint one quarter 2592 reported calculation antecedent almost onethird reported disagreement collective responsibility antecedent 2592 chisquare test revealed gender employment status parents covid19 vaccination status significantly associated p005 vaccine hesitancy among parents assessing influence transactional ehealth literacy communication component contained significant association p005 among 5c psychological antecedents confidence calculation collective responsibility significantly associated p005 vaccine hesitancy parents secondary 880 ci 2443179 p005 postsecondary 521 ci 2101341 p005 tertiary education 677 ci 2252035 p005 significantly higher likelihood vaccine hesitancy primary education highly educated parents skeptical likely perceive vaccine unsafe ineffective children critical disseminate required information vaccine safety educated group