Naved Alam, Warisha Mariam
Impact of tobacco habits on poor oral health status among bone-factory workers in a low literacy city in India: A cross-sectional study
PloS one
alzheimers disease ad broadly characterized neurodegeneration pathology accumulation cognitive decline considerable variation progression clinical symptoms pathology humans highlighting importance genetic diversity study ad address analyze cell composition amyloidbeta deposition 6 14monthold adbxd mouse brains utilize analytical quint workflow suite software designed support atlasbased quantification expand deliver highly effective method registering quantifying cell pathology changes diverse disease models applying expanded quint workflow quantify nearglobal agerelated increases microglia astrocytes amyloidbeta identify strainspecific regional variation neuron load understand individual differences cell composition affect interpretation bulk gene expression ad combine hippocampal immunohistochemistry analyses bulk rnasequencing data approach allows us categorize genes whose expression changes response ad cell andor pathology loaddependent manner ultimately study demonstrates use quint workflow standardize quantification immunohistochemistry data diverse mice providing valuable insights regional variation cellular load amyloid deposition adbxd model