Nisha Nigil Haroon|Peter C. Austin|Baiju R. Shah|Jianbao Wu|Sudeep S. Gill|Gillian L. Booth
Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study
University of Toronto|Institute for Clinical Evaluative Sciences|University of Toronto|Institute for Clinical Evaluative Sciences|Institute for Clinical Evaluative Sciences|Institute for Clinical Evaluative Sciences|Queen's University|University of Toronto|Institute for Clinical Evaluative Sciences
objective study whether diabetes onset late life risk factor dementia research design methods conducted populationbased matched cohort study using provincial health data ontario canada seniors n 225045 without newly diagnosed diabetes n 668070 april 1995 march 2007 followed march 2012 new diagnosis dementia cox proportional hazards modeling used compare risk dementia groups adjusting baseline cardiovascular disease chronic kidney disease ckd hypertension risk factors results period observed 169114 new cases dementia individuals diabetes modestly higher incidence dementia 268 vs 262 per 100 personyears without diabetes fully adjusted cox model risk dementia 16 higher among subgroup diabetes hazard ratio hr 116 95 ci 115118 adjusted hrs dementia 120 95 ci 117122 114 95 ci 112116 among men women respectively among seniors diabetes risk dementia greatest prior cerebrovascular disease hr 203 95 ci 188219 peripheral vascular disease hr 147 95 ci 119182 ckd hr 144 95 ci 138151 one hospital visits hypoglycemia hr 173 95 ci 162184 conclusions populationbased study newly diagnosed diabetes associated 16 increase risk dementia among seniors preexisting vascular disease severe hypoglycemia greatest risk factors dementia seniors diabetes