Flaviane Cristina Rocha Cesar, Lizete Malagoni de Almeida Cavalcante Oliveira, Mariana Cristyen Galvão, Ana Luiza Andrade Lacerda
How Do Healthcare Professionals Develop the Communication Process to Promote Patients' Health Literacy?
International journal of environmental research and public health
identification spatiotemporally restricted ca2 signals ca2 sparks instrumental understanding cardiac ca2 homeostasis highspeed 2d confocal imaging enables acquisition ca2 sparks highcontent information full appreciation constrained lack unbiased easytouse analysis tools developed software toolset unbiased automatic ca2 spark analysis huge data sets subcellular ca2 signals ispark developed scanner detector independent myocytes hearts subjected various degrees hypertrophy acquired 5000000 ca2 sparks 14 mice isparkenabled analysis large ca2 spark data set showed highly organized distribution ca2 sparks present healthy cells disarrayed concomitant development aberrant transverse tubules disease severity thus ispark represents versatile universal tool analyzing local ca2 signaling healthy well diseased aberrant local ca2 signal transduction results unbiased analysis large data sets provide deeper insight possible mechanisms contributing onset progression cardiac diseases hypertrophy