Getahun Dejene Yemane, Birhanu Bedada Korsa, Sebwedin Surur Jemal
Multilevel analysis of factors associated with pregnancy termination in Ethiopia
Annals of medicine and surgery (2012)
precision medicine pm raises key question know works number people health problem becomes small one n 1 present formative case norway norwegian board health supervision faced cancer patient improved treatment drug private health sector refused continued treatment public health service due lack clinical trial evidence board overturned decision arguing drug unambiguously documented work individual case aim provide indepth analysis case boards decision thereby illustrate elucidate key epistemological ethical issues developments pm provide analysis discussion using tools critical thinking concepts philosophy science medicine uncertainty evidence forms inference causation also examine case light history evidencebased medicine ebm case reflects epistemological shift medicine pm puts greater emphasis evidence arises individual patients treatment provided preexisting populationbased evidence pm may rely heavily abduction decide works qualitative rather quantitative judgements case also illustrates possible shift concept causation regularity accounts mechanistic process accounts discuss ethical implications shift traditional personalised ebm framework based abductions evidence arising individual case problems creating quantifiable reliable generalisable evidence promoting transparency accountability pm currently lacks clear criteria deciding works individual posing ethical challenges