Bernd Blobel, Frank Oemig, Pekka Ruotsalainen, Mathias Brochhausen, Mauro Giacomini
The Representational Challenge for Designing and Managing 5P Medicine Ecosystems
Studies in health technology and informatics
digital twin defined virtual representation physical asset enabled data simulators realtime prediction optimization monitoring controlling improved decision making recent advances computational pipelines multiphysics solvers artificial intelligence big data cybernetics data processing management tools bring promise digital twins impact society closer reality digital twinning important emerging trend many applications also referred computational megamodel device shadow mirrored system avatar synchronized virtual prototype doubt digital twin plays transformative role design operate cyberphysical intelligent systems also advance modularity multidisciplinary systems tackle fundamental barriers addressed current evolutionary modeling practices work review recent status methodologies techniques related construction digital twins mostly modeling perspective aim provide detailed coverage current challenges enabling technologies along recommendations reflections various stakeholders