Khushboo Bisht, Bharathi Mohan, Basavaraj Jatteppanavar, Hannah Theresa Sony, Shailendra Handu, Minakshi Dhar
An observational study of root-cause analysis of medication errors in elderly with methotrexate toxicity
Expert opinion on drug safety
analysis functional neuroimaging data aims unveil spatial temporal patterns interest existing analysis methods fall two categories fully datadriven approaches reliant prior information eg stimulus time course using stimulus signal directly help identify activated brain areas known relationship stimuli brains response exhibits nonlinear timevarying characteristics relying completely stimulus signal describe brains temporal response leads restricted interpretation brain function paper present new technique called evoked component analysis eca leverages prior information defined extent achieved including general linear model glm design matrix regulatory term estimating factor matrices space time alternating minimization approach apply eca 2d swept3d functional ultrasound fus experiments conducted mice decomposing 2d fus data employ glm regularization various intensities emphasize role prior information furthermore show incorporating multiple hemodynamic response functions within design matrix provide valuable insights regionspecific characteristics evoked activity finally use eca analyze swept3d fus data recorded five mice engaged two distinct visual tasks swept3d fus images 3d brain sequentially using moving probe resulting different slice acquisition time instants show eca estimate factor matrices fine resolution slice acquisition time instant yield higher tstatistics compared glm correlation analysis subjects