Steve Bennett
Investigation of Environmental and Host-related Risk Factors for Tuberculosis in Africa. II. Investigation of Host Genetic Factors
accompanying paper j epidemiol 2002155106673 authors describe design large multicenter study carried three west african countries investigation roles environmental hostrelated factors development tuberculosis paper authors review evidence host genetic factors play role susceptibility tuberculosis describe three components study designed investigate effect host genetic factors development tuberculosis casecontrol familybased association studies candidate genes analysis affected relative pairs screen human genome areas linkage disease authors also address number methodological issues arise effects consanguinity halfsiblings nonpaternity lastly review opportunities assess geneenvironment interaction framework study light current methodological knowledge consideration issues may useful design studies genetic susceptibility infectious diseases particularly carried developing countries