Lawrence Mbuagbaw|Theresa Aves|Beverley Shea|Janet Jull|Vivian Welch|Monica Taljaard|Manosila Yoganathan|Regina Greer-Smith|George Wells|Peter Tugwell
Considerations and guidance in designing equity-relevant clinical trials
McMaster University|Impact|McMaster University|Impact|University of Ottawa|Ottawa Hospital|Ottawa Hospital|University of Ottawa|Bruyère|Ottawa Hospital|Bruyère|University of Ottawa|University of Ottawa|University of Ottawa
health research documented disparities health health outcomes within populations disparities unfair avoidable may referred health inequities trials attend factors related health inequities limited understanding build consideration health inequities trials due consideration health inequities important inform design conduct reporting trials research build evidence effectively address health inequities importantly ensure inequities aggravated paper discuss approaches integrating health equityconsiderations randomized trials using progress plus framework place residence raceethnicityculturelanguage occupation gender religion education socioeconomic status social capital plus includes context specific factors cover formulation research questions ii two specific scenarios relevant trials health equity iii describe progress plus characteristics may influence trial design conduct analyses guidance intended support trialists designing equityrelevant trials lead better design conduct analyses reporting addressing two main issues avoid aggravating inequity among research participants produce information useful decisionmakers concerned health inequities