Michael S. Wolf|Terry C. Davis|Laura M. Curtis|Stacy Cooper Bailey|Jo Ann Pearson Knox|Ashley R. Bergeron|Mercedes Abbet|William H. Shrank|Ruth M. Parker|Alastair J.J. Wood
A Patient-Centered Prescription Drug Label to Promote Appropriate Medication Use and Adherence
Northwestern University|Louisiana State University Health Sciences Center Shreveport|Northwestern University|University of North Carolina at Chapel Hill|Northwestern University|CVS Health (United States)|Emory University|Cornell University
patient misunderstanding prescription drug label instructions common cause unintentional misuse medication adverse health outcomes limited literacy english proficiency greater riskto test effectiveness patientcentered drug label strategy including universal medication schedule ums improve proper regimen use adherence compared current standardtwoarm multisite patientrandomized pragmatic trialenglish spanishspeaking patients eight community health centers northern virginia received prescriptions centralfill pharmacy 1 30 years age 2 diagnosed type 2 diabetes andor hypertension 3 taking 2 oral medicationsa patientcentered label pcl strategy incorporated evidencebased practices format content including prioritized information larger font size increased white space notably instructions conveyed ums uses standard intervals expressing take medicine morning noon evening bedtimedemonstrated proper use multidrug regimen medication adherence measured selfreport pill count 3 9 monthsa total 845 patients participated study 856 cooperation rate patients receiving pcl demonstrated slightly better proper use drug regimens first exposure 769 vs 701 p 006 9 months 859 vs 774 p 003 effect pcl significant englishspeaking patients 221 95 ci 113431 spanish speakers 119 95 ci 063224 overall intervention improve medication adherence however significant benefits pcl found among patients limited literacy 508 95 ci 1152237 medications taken 2 times day 277 95 ci 117653a simple modification pharmacygenerated labeling minimal investment required offer modest improvements regimen use adherence mostly among patients limited literacy complex regimens trial registration clinicaltrialsgov nct00973180 nct01200849