Karine Bilodeau, Cynthia Henriksen, Camila Aloisio Alves, Lynda Piché, Jacinthe Pepin, Virginia Lee, Marie-France Vachon, Nathalie Folch, Marie-Pascale Pomey, Nicolas Fernandez
Learning to provide humanistic care and support in the context of chronic illness: Insights from the narratives of healthcare professionals in hemato-oncology
European journal of oncology nursing : the official journal of European Oncology Nursing Society
neurodegenerative diseases alzheimers disease ad follow slowly progressing dysfunctional trajectory large presymptomatic component many comorbidities using preclinical models largescale omics studies ranging genetics imaging large number processes might involved ad pathology different stages levels identified sheer number putative hypotheses makes almost impossible estimate contribution clinical outcome develop comprehensive view pathological processes driving clinical phenotype traditionally bioinformatics approaches provided correlations associations processes phenotypes focusing causality new breed advanced quantitative modeling approaches use formalized domain expertise offer new opportunities integrate different modalities outline possible paths toward new therapeutic interventions article reviews three different computational approaches possible complementarities process algebras implemented using declarative programming languages maude facilitate simulation analysis complicated biological processes comprehensive coarsegrained level modeldriven integration data knowledge based openbel platform using reverse causative reasoning network jump analysis generate mechanistic knowledge new mechanismbased taxonomy disease finally quantitative systems pharmacology based formalized implementation domain expertise finegrained mechanismdriven quantitative predictive humanized computer model propose strategy combine strengths individual approaches developing powerful modeling methodologies provide actionable knowledge rational development preventive therapeutic interventions development computational approaches likely required progress understanding treating ad