Miguel Ángel Aguilar-Jurado, Pedro Gil-Madrona, Juan Francisco Ortega-Dato, David Zamorano-García
Effects of an Educational Glass Recycling Program against Environmental Pollution in Spain
International journal of environmental research and public health
resting state functional magnetic resonance imaging rfmri offers insight synchrony within brain networks altered disease states individual diseaserelated variability intrinsic connectivity networks may influence interpretation rfmri data used personalized approach designed account individual variation spatial location correlation maxima evaluate rfmri differences parkinsons disease pd patients showed cognitive decline remained cognitively stable cognitively stable controls compared fmri data participant groups studied baseline 18 months later using networkbased statistics nbs calculations mean inter intranetwork connectivity within predefined functional networks nbs analysis showed pd participants remained cognitively stable showed exclusively baseline predominantly followup increased intranetwork connectivity whereas decliners showed exclusively reduced intranetwork inter ventral attention default mode connectivity comparison control group evaluation mean connectivity regions interest rois within priori networks showed decliners consistently reduced internetwork connectivity ventral attention somatomotor visual striatal networks reduced intranetwork connectivity ventral attention network striatum cerebellum findings suggest specific functional connectivity covariance patterns differentiate pd cognitive subtypes may predict cognitive decline increased intra internetwork synchrony may support cognitive function face pdrelated network disruptions