Yu Fan, Liang Zhou, Xiyuan Chen, Jinghua Su, Shaoling Zhong
Determinants and outcomes of health-promoting lifestyle among people with schizophrenia
BMC psychiatry
cognitive dysfunction correlated seizure control chronic epilepsy newly diagnosed epilepsy potentially makes good marker predicting disease course seizure control however lack prospective studies examining role cognitive dysfunction predicting seizure recurrence earliest stages disease following first unprovoked seizure ufs new onset epilepsy noe thirty three adult participants fs18 noe15 halifax first seizure clinic hfsc completed cognitive screening assessment baseline typically 3 months following diagnosis seizurerecurrence evaluated one year initial hfsc visit cognitive impairment defined least one zscore impaired range 15 relative published test norms documented 76 patients seizure recurrence followup 55 without seizure recurrence speedexecutive functions memory frequently affected domains impaired performance noted 35 29 entire sample respectively although seizure recurrence vs nonrecurrence groups differ significantly likelihood impairment specific cognitive domains regression model seizure recurrence included years education baseline mood anxiety scores normal vs abnormal baseline mri impaired vs unimpaired function six cognitive domains significant overall 2 10 2404 p 007 r2n 77 regression model longer significant cognitive variables removed subtle cognitive dysfunction especially domains executive functions memory prevalent individuals earliest stages epilepsy addition abnormal mri eeg findings baseline far less prevalent fs noe cognitive factors show promise helping predict seizure recurrence populations