Cinnamon S. Bloss|Nathan E. Wineinger|Burcu F. Darst|Nicholas J. Schork|Eric J. Topol
Impact of direct-to-consumer genomic testing at long term follow-up
Scripps (United States)|Scripps Institution of Oceanography|Scripps Research Institute|Scripps Health|Scripps Research Institute|Scripps Health|Scripps Research Institute|Scripps Health|Scripps Research Institute|Scripps Clinic Medical Group|Scripps Health
empirical data inform debate surrounding use regulation directtoconsumer dtc genomewide disease risk tests study aimed determine long term psychological behavioural clinical impacts genomic risk testing common diseasethe scripps genomic health initiative prospective longitudinal cohort study adults purchased navigenics health compass commercially available genomic test web based assessments administered baseline short 3 months long term 1 year followup2240 participants completed either followups subset 1325 completed long term followup significant differences baseline anxiety p050 fat intake p034 exercise p039 long term followup 968 sample test related distress longitudinal linear mixed model analyses consistent results crosssectional analyses screening test completion associated sharing genomic test results physician 360 shared p0001 perceived utility test 615 high perceived utility p0002 associated genomic risk estimate values themselvesover third dtc genomic test recipients shared results physician approximate 1 year followup period sharing associated higher screening test completion genomic testing associated long term psychological risks participants reportedly perceived test high personal utility