Elena Lammila-Escalera, Geva Greenfield, Reham Aldakhil, Hadar Zaman, Ana Luisa Neves, Azeem Majeed, Benedict Wj Hayhoe
Structured medication reviews for adults with multimorbidity and polypharmacy in primary care: a systematic review protocol
BMJ open
current knowledge radiobiology ascribes adverse biological effects ionizing radiation primarily induction dna doublestrand breaks dsbs supposed potentially lethal may converted lethal damage due misrepair soft ultrasoft xrays found bear elevated biological effectiveness cell killing compared conventional xrays 60co rays phenomenon qualitatively interpreted increased level dsb induction low energy photons however thorough quantitative reasoning lacking systematically compared relative biological effectiveness rbe relative dsb induction photons several hundreds ev mev although approximate twofold increase yields dsb low energy photons found calculation large number experimental measurements far enough account three fourfold increase rbe theoretical investigations show dsb complexity additional singlestrand breaks base damage within 10 base pairs increases notably low energy photons largely reconciles discrepancy rbe dsb induction theoretical results line accumulating experimental evidence complex dsbs refractory repair machinery may contribute predominantly formation lethal damage