Steven Paul Woods|Matthew Dawson|Erica Weber|Sarah A. Gibson|Igor Grant|J. Hampton Atkinson
Timing is everything: Antiretroviral nonadherence is associated with impairment in time-based prospective memory
University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego
abstract nonadherence combination antiretroviral arv therapies cart highly prevalent significantly increases risk adverse human immunodeficiency virus hiv disease outcomes current study evaluated hypothesis prospective memorya dissociable aspect episodic memory describing ability execute future intentionplays important role successful cart adherence seventynine individuals hiv infection prescribed least one arv medication underwent comprehensive neuropsychological neuromedical evaluation prior completing 1month observation cart adherence measured electronic medication monitoring nonadherent individuals n 31 demonstrated significantly poorer prospective memory functioning compared adherent persons n 48 particularly index timebased prom ie elevated loss time errors deficits timebased prospective memory independently predictive cart nonadherence even considering possible influence established predictors adherence general cognitive impairment eg retrospective learning memory psychiatric comorbidity eg depression findings extend nascent literature showing impairment timebased prospective memory significantly increases risk medication nonadherence therefore may guide development novel strategies intervention jins 2009 15 4252