Cari Jo Clark, Gemma Ferguson, Soham Subedi, Arti Lad, Alexandria Ree Hadd, Binita Shrestha, Abbie Shervinskie, Shweta Tomar, Holly Baker
Social norms, diffusion, and women's risk of intimate partner violence in Nepal: Impact assessment of a social and behavior Change communication intervention (Change Starts at home)
SSM - population health
immunoglobulin igg antibodies coordinate immune effector responses selectively binding target antigens interacting various effector cells via fc receptors fc domain igg promote inhibit distinct effector responses across several different immune cell types variation based subclass fc domain glycosylation extensive characterization interactions revealed inclusion certain fc subclasses glycans results distinct immune responses immune response however igg produced mixtures fc domain properties antigenigg immune complexes likely almost always comprised combination fc forms whether mixed composition influences immune effector responses examined measured fc receptor binding immune complexes mixed fc domain composition found binding properties mixedcomposition immune complexes fell along continuum corresponding pure cases binding quantitatively matched mechanistic binding model except several lowaffinity interactions mostly involving igg2 found affinities interactions different previously reported binding model could used provide refined estimates affinities finally demonstrated binding model predict effectorcell elicited platelet depletion humanized mice model inferring relevant effector cell populations contrary previous view igg2 poorly engages effector populations observe appreciable binding avidity insufficient amounts observe immune effector responses overall work demonstrates quantitative framework reasoning effector response regulation arising igg mixed fc composition binding behavior mixed fc immune complexes blend binding properties constituent igg speciesan equilibrium multivalent binding model generalized incorporate immune complexes mixed fc compositionparticularly lowaffinity iggfc receptor interactions immune complexes provide better estimates affinitiesthe fcr binding model predicts effectorelicited cell clearance humanized mice