Yaakov Stern|Eric Zarahn|Christian Habeck|Roee Holtzer|Brian C. Rakitin|Alan Prem Kumar|Joseph Flynn|Jason Steffener|Truman R. Brown
A Common Neural Network for Cognitive Reserve in Verbal and Object Working Memory in Young but not Old
Columbia University|Columbia University|Albert Einstein College of Medicine|Yeshiva University|Columbia University|Columbia University
epidemiologic evidence suggests cognitive reserve cr mitigates effects aging cognitive function goal study see whether common neural mechanism cr could demonstrated brain imaging data acquired performance 2 tasks differing cognitive processing demands young elder subjects scanned functional magnetic resonance imaging fmri performing delayed item response task used either letters 40 young 18 old shapes 24 young 21 old difficulty load manipulated varying number stimuli presented encoding loaddependent fmri signal corresponding trial component stimulus presentation retention delay probe task letter shape regressed onto 2 putative cr variables canonical variates analysis applied resulting maps regression coefficients separately trial component summarize imaging datacr relationships latent brain pattern noted stimulus presentation phase manifested similar relationships loadrelated encoding activation cr variables across letter shape tasks young elder age group spatial pattern could represent general neural instantiation cr affected aging process