Lindsay R. Clark|Annie M. Racine|Rebecca L. Koscik|Ozioma C. Okonkwo|Corinne D. Engelman|Cynthia M. Carlsson|Sanjay Asthana|Barbara B. Bendlin|Rick Chappell|Christopher R. Nicholas|Howard A. Rowley|Jennifer M. Oh|Bruce P. Hermann|Mark A. Sager|Bradley T. Christian|Sterling C. Johnson
Beta?amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study
University of Wisconsin–Madison|University of Wisconsin–Madison|Institute on Aging|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center
abstract introduction present study investigated relationship betaamyloid cognition late middleaged cohort risk alzheimers disease ad methods one eightyfour participants mean age 60 72 parental history ad completed c11pittsburgh compound b positron emission tomography scan serial cognitive evaluations global measure burden calculated composite scores assessing learning delayed memory executive functioning computed results higher associated classification psychometric mild cognitive impairment mci followup p lt 01 linear mixed effects regression results indicated higher associated greater rates decline delayed memory p lt 01 executive functioning p lt 05 apolipoprotein e apoe 4 status moderated relationship cognitive trajectories p values lt01 discussion individuals risk ad greater late middle age associated increased likelihood mci followup steeper rates cognitive decline