Myoungock Jang, Margaret Grey, Lois Sadler, Sangchoon Jeon, Soohyun Nam, Hee-Jung Song, Robin Whittemore
Obesity-risk behaviours and their associations with body mass index (BMI) in Korean American children
Journal of clinical nursing
investigate pharmacokinetics efficacy convulsive dose articaine hydrochloride goat kids experimental prospective study total 18 n 6 animals per experiment male saanen goat kids 24 weeks old study consisted three experiments first determined pharmacokinetics articaine following intravenous administration articaine hydrochloride 8 mg kg1 second experiment investigated anaesthetic efficacy pharmacokinetics following cornual nerve block using 15 articaine hydrochloride anaesthesia horn buds evaluated using response pinprick test noncompartmental analysis used final experiment determined convulsive dose articaine corresponding plasma concentration following intravenous infusion articaine hydrochloride 4 mg kg1 minute1 data shown mean standard deviation mean terminal halflife t12z mean volume distribution steady state vdss mean plasma clearance cl articaine following intravenous administration 066 hour 381 l kg1 533 l hour1 kg1 respectively cornual nerve block mean maximum plasma concentration articaine 587 ng ml1 022 hour mean t12z 126 hours anaesthesia horn buds observed within 4 minutes following cornual nerve block mean dose required produce convulsions 1624 mg kg1 mean convulsive plasma concentrations articaine articainic acid 9905 1517 ng ml1 respectively intravenous administration 8 mg kg1 articaine hydrochloride cause adverse effects pharmacokinetic data suggest articaine rapidly eliminated cleared cornual nerve block using 15 articaine hydrochloride alleviated response acute nociceptive stimulus disbudding articaine hydrochloride appears safe effective local anaesthetic disbudding goat kids