Desiree Byrd|Robert P Fellows|Susan Morgello|Donald Franklin|Robert K. Heaton|Reena Deutsch|J. Hampton Atkinson|David B. Clifford|Ann C. Collier|Christina M. Marra|Benjamin B. Gelman|J. Allen McCutchan|Nichole A. Duarte|David M. Simpson|Justin C. McArthur|Igor Grant
Neurocognitive Impact of Substance Use in HIV Infection
Icahn School of Medicine at Mount Sinai
determine serious confound substance use su might studies hivassociated neurocognitive disorder hand examined relationship su history neurocognitive impairment nci participants enrolled central nervous system hiv antiretroviral therapy effects research study excluding cases behavioral evidence acute intoxication histories factors independently could account nci eg stroke baseline demographic medical su neurocognitive data analyzed 399 participants potential su risk nci determined following criteria lifetime su diagnostic statistical manual mental disorders fourth edition diagnosis selfreport marked lifetime su positive urine toxicology participants divided 3 groups follows su n 134 nonsyndromic su n 131 syndromic su n 134 matched literacy level nadir cd4 depressive symptoms although approximately 50 participants diagnosed hand multivariate analysis covariance neurocogntive summary scores covarying urine toxicology revealed significant effect su status correlational analyses indicated weak associations lifetime heroin dosage poor recall working memory cannabis cocaine use better verbal fluency data indicate hiv neurocognitive effects seen frequency without historic substance abuse cases equated factors might contribute nci therefore studies neuroaids treatment need exclude cases however effects acute su current su disorders hand require study