J M J Isautier, S Wang, N Houssami, K McCaffery, M E Brennan, T Li, B Nickel
The impact of breast density notification on psychosocial outcomes in racial and ethnic minorities: A systematic review
Breast (Edinburgh, Scotland)
cognitive impairment common neurological presentations wilsons disease wd various domains affected subclinical deficits reported patients hepatic presentations associations imaging abnormalities systematically tested aim determine neuroanatomical basis cognitive deficits wd performed 16item neuropsychological test battery magnetic resonance brain imaging 40 patients wd scores test compared patients neurological hepatic presentations normative data associations unified wilsons disease rating scale neurological examination subscores examined quantitative wholebrain multimodal imaging analyses used identify associations neuroimaging abnormalities chronically treated stable patients abstract reasoning executive function processing speed calculation visuospatial function scores lower patients neurological presentations hepatic presentations correlated neurological examination subscores deficits abstract reasoning phonemic fluency associated lower putamen volumes even controlling neurological severity half patients hepatic presentations poor performance memory faces cognitive flexibility associative learning relative normative data deficits associated widespread cortical atrophy andor white matter diffusion abnormalities subtle cognitive deficits patients seemingly hepatic presentations represent distinct neurological phenotype associated diffuse cortical white matter pathology may precede classical neurological phenotype characterized movement disorders executive dysfunction associated basal ganglia damage binary phenotypic classification wd may longer appropriate 2022 authors movement disorders published wiley periodicals llc behalf international parkinson movement disorder society