Tansy Edwards|Anthony Scott|Gilbert Munyoki|Victor Mung’ala Odera|Eddie Chengo|Evasius Bauni|Thomas Kwasa|Josemir W. Sander|Brian Neville|Charles R. Newton
Active convulsive epilepsy in a rural district of Kenya: a study of prevalence and possible risk factors
London School of Hygiene & Tropical Medicine|Kenya Medical Research Institute|University of Oxford|University of Nairobi|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Epilepsy Research UK|University College London|Kenya Medical Research Institute|University College London
largescale studies epilepsy done subsaharan africa aimed estimate prevalence treatment gap possible risk factors active convulsive epilepsy kenyan people aged 6 years older living rural areawe undertook threephase screening survey 151408 individuals followed nested community casecontrol study treatment gap defined proportion cases active convulsive epilepsy without detectable amounts antiepileptic drugs bloodoverall prevalence active convulsive epilepsy 29 per 1000 95 ci 2632 adjustment nonresponse sensitivity prevalence 45 per 1000 4149 substantial heterogeneity noted prevalence evidence clustering treatment gap 703 659745 weak evidence difference sex area adjusted odds active convulsive epilepsy individuals increased family history nonfebrile convulsions odds ratio 33 95 ci 2447 p00001 family history febrile convulsions 146 63341 p00001 history seizure types 73 33164 p00001 previous head injury 41 2181 p00001 findings multivariable analyses children showed adverse perinatal events 57 26127 p00001 childs mother widow 51 24110 p00001 raised odds active convulsive epilepsysubstantial heterogeneity exists prevalence active convulsive epilepsy rural area kenya assessment prevalence treatment use demographic variation screening response helped identify groups targeted interventions adverse perinatal events febrile illness head injury potentially preventable associated factors epilepsy region