Giacomo Scaioli, Manuela Martella, Giuseppina Lo Moro, Alessandro Prinzivalli, Laura Guastavigna, Alessandro Scacchi, Andreea Mihaela Butnaru, Fabrizio Bert, Roberta Siliquini
Knowledge, Attitudes, and Practices about Electronic Personal Health Records: A Cross-Sectional Study in a Region of Northern Italy
Journal of medical systems
alzheimers disease ad common form agerelated dementia leading decline memory reasoning social skills numerous studies investigated genetic risk factors associated ad less attention given identifying brain imagingbased measure ad risk study introduces novel approach assess mild cognitive impairment mci stage ad risk using neuroimaging data referred brainwide risk score brs incorporates multimodal brain imaging begin first categorized participants open access series imaging studies oasis3 cohort two groups controls cn individuals mci next computed structure functional imaging features oasis data well uk biobank data resting functional magnetic resonance imaging fmri data computed functional network connectivity fnc matrices using fully automated spatially constrained independent component analysis structural mri data computed gray matter gm segmentation maps evaluated similarity participants neuroimaging features uk biobank difference average features cn individuals mci refer brainwide risk score brs gm fnc features utilized determining brs first evaluated differences distribution brs cn vs mci within oasis3 using oasis3 reference group next evaluated brs alzheimers disease neuroimaging initiative adni cohort using oasis3 reference group showing brs differentiate mci cn independent data set subsequently using smri brs identified 10 distinct subgroups similarly identified another set 10 subgroups using fnc brs smri fnc observed results mutually validate certain aspects complementary unimodal analysis smri provides greater differentiation mci cn individuals fmri data consistent prior work additionally utilizing multimodal brs approach combines gm fnc assessments identified two groups subjects using multimodal brs scores one group exhibits high mci risk negative gm fnc brs shows low mci risk positive gm fnc brs moreover ukbb 46 participants diagnosed ad showed fnc gm patterns similar highrisk groups defined unimodal multimodal brs finally ensure reproducibility findings conducted validation analysis using adni additional reference dataset repeated analysis results consistently replicated across different reference groups highlighting potential fnc smribased brs early alzheimers detection