Mette Heringa|Annemieke Floor?Schreudering|Hans Wouters|Peter A. G. M. De Smet|Marcel L. Bouvy
Preferences of Patients and Pharmacists with Regard to the Management of Drug–Drug Interactions: A Choice-Based Conjoint Analysis
SIR Institute for Pharmacy Practice and Policy|SIR Institute for Pharmacy Practice and Policy|University of Groningen|Radboud University Nijmegen|Radboud University Medical Center|Utrecht University
management drugdrug interactions ddis complex process riskbenefit assessments combined patients perspective aim study determine patients pharmacists preferences regarding ddi management conducted choicebased conjoint survey fictitious ddi concerning combination cardiovascular drug antibiotic pneumonia patients pharmacists choose 12 times two management options options described five attributes including risk benefit practical consequences attribute could two different levels varied choice tasks latent class analysis used identify potential classes respondents distinct patterns similar preferences total 298 patients 178 pharmacists completed questionnaire latent class model patients pharmacists resulted three classes patients one class importance attached avoiding switch medication class probability 20 second class fewer adverse events 41 third class blood sampling 39 pharmacists one class attached highest importance avoiding switch medication 31 classes gave priority curing pneumonia 31 avoiding blood sampling 38 results showed diverging preferences regarding ddi management among patients pharmacists different groups attached different value risk benefit versus practical considerations awareness existing variability preferences among pharmacists patients step towards shared decision making ddi management