Kamlesh Khunti|Saud Alsifri|Ronnie Aronson|Maja Cigrovski Berkovi?|Catherine Enters-Weijnen|Tom Forsén|Gagik R. Galstyan|Petronella Geelhoed-Duijvestijn|Margalit Goldfracht|Helge Gydesen|Rahul Kapur|Nebojša Lali?|Bernhard Ludvik|Erik Moberg|Ulrik Pedersen?Bjergaard|Ambady Ramachandran
Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin?treated type 1 and type 2 diabetes: the global <scp>HAT</scp> study
University of Leicester|Armed Forces Hospital|LMC Diabetes & Endocrinology (Canada)|Sisters of Charity Hospital|University Medical Center Utrecht|University of Helsinki|Endocrinology Research Center|Medisch Centrum Haaglanden|Clalit Health Services|Novo Nordisk (Denmark)|Novo Nordisk (Denmark)|University of Belgrade|Rudolfinerhaus Hospital|Medical University of Vienna|Karolinska Institutet|Nordsjællands Hospital|India Diabetes Research Foundation|Dr. A. Ramachandran's Diabetes Hospitals
aims determine global extent hypoglycaemia experienced patients diabetes using insulin lack data prevalence hypoglycaemia developed developing countries methods noninterventional multicentre 6month retrospective 4week prospective study using selfassessment questionnaire patient diaries included 27 585 patients aged 18 years type 1 diabetes t1d n 8022 type 2 diabetes t2d n 19 563 treated insulin gt12 months 2004 sites 24 countries worldwide primary endpoint proportion patients experiencing least one hypoglycaemic event observational period results prospective period 830 patients t1d 465 patients t2d reported hypoglycaemia rates nocturnal severe hypoglycaemia 733 95 confidence interval ci 726740 113 95 ci 110116 49 95 ci 4751 eventspatientyear t1d 193 95 ci 191196 37 95 ci 3638 25 eventspatientyear 95 ci 2425 t2d respectively highest rates hypoglycaemia observed latin america t1d russia t2d glycated haemoglobin level significant predictor hypoglycaemia conclusions report hypoglycaemia rates global population including countries without previous data overall hypoglycaemia rates high large variations geographical regions investigation differences may help optimize therapy reduce risk hypoglycaemia