Benjamin Y Avuwadah, Jaclyn D Kropp
Impact of introducing a farm to school program on the number of school lunches served
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therapy concepts target several members krppel like factor klf family achieved breast cancer bc however role klf11 bc remains unclear study explored prognostic significance klf11 bc patients investigated functional roles malignancy immunohistochemistry ihc staining klf11 298 patients samples performed determine prognostic role klf11 protein level correlated clinicopathological characteristics survival outcomes afterward function klf11 explored vitro sirnamediated lossoffunction cell viability proliferation apoptosis cohort study found expression klf11 positively associated highly proliferative bc bc furthermore prognostic analysis demonstrated klf11 independent negative factor diseasefree survival dfs distantmetastasisfree survival dmfs bc klf11related prognostic model dfs dmfs showed high accuracy predicting 35 10 year survival probability bc patients additionally knockdown klf11 inhibited cell viability proliferation well induced cell apoptosis mcf7 mdamb231 cells inhibited cell viability induced cell apoptosis skbr3 cells study indicated targeting klf11 interesting therapeutic concept research could lead new therapeutic improvement bc especially highly aggressive molecular subtypes