Daiki Kobayashi, Kyoko Yokota, Shizuka Yamagata-Uyama, Mayuko Saito
Follow-up evaluation for norovirus asymptomatic infection among healthy adults: a prospective matched cohort study
Infectious diseases (London, England)
oral endocrine treatments shown effective carefully adhered however patients early breast cancer adherence challenges notable 17 experiencing nonpersistence 41 nonadherence least model persistence adherence oral anticancer treatment patient localized breast cancer cohort study conducted using anonymous reimbursement data belonging french female patients breast cancer extracted french health insurance database january 2013 december 2018 data analysis conducted january 2021 may 2022 main outcome detection episodes nonpersistence nonadherence 6 months happened adherence defined ratio time covered drug purchase time 2 purchases patients considered nonadherent ratio next 3 purchases less 80 disparities persistence adherence based criteria age treatment type income identified total 229 695 female patients median iqr age 63 5272 years localized breast cancer included deep learning model based gatedrecurrent unit architecture used detect episodes nonpersistence nonadherence model demonstrated area receiving operating curve 071 persistence 073 adherence analyzing shapley additive explanations values also gave insights contribution different features models decision patients older 70 years past nonadherence taking 1 treatment previous 3 months low income greater risk episodes nonpersistence age past nonadherence including regularity past adherence also important features nonadherence model cohort study found associations patient age past adherence nonpersistence nonadherence also suggested regular intervals treatment purchases enhanced adherence contrast irregular purchasing patterns research offers valuable tools improving persistence adherence oral anticancer treatment among patients early breast cancer