T E Dielman, J T Shope, S L Leech, A T Butchart
Differential effectiveness of an elementary school-based alcohol misuse prevention program
The Journal of school health
current widespread adoption nextgeneration sequencing ngs branches basic research clinical genetics fields means users highly variable informatics skills computing facilities application purposes need process analyse interpret ngs data landscape versatility scalability userfriendliness key characteristics ngs analysis software developed dnascan2 highly flexible endtoend pipeline analysis ngs data used detection multiple variant types including snvs small indels transposable elements short tandem repeats large structural variants ii covers standard steps ngs analysis quality control raw data genome alignment variant calling annotation generation reports interpretation prioritization results iii highly adaptable deployed run via either graphic user interface nonbioinformaticians command line tool personal computer usage iv scalable executed parallel snakemake workflow v computationally efficient minimizing ram cpu time requirements dnascan2 implemented python3 available httpsgithubcomkhpinformaticsdnascanv2