Carolina Ciumas|Mani Saignavongs|Faustine Ilski|Vania Herbillon|Agathe Laurent|Amélie Lothe|Rolf A. Heckemann|Julitta de Bellescize|Eleni Panagiotakaki|Salem Hannoun|Dominique Sappey-Marinier|Alexandra Montavont|Karine Ostrowsky?Coste|Nathalie Bedoin|Philippe Ryvlin
White matter development in children with benign childhood epilepsy with centro-temporal spikes
Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|Inserm|French National Centre for Scientific Research|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|Inserm|French National Centre for Scientific Research|French National Centre for Scientific Research|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|Inserm|Hospices Civils de Lyon|Hospices Civils de Lyon|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|French National Centre for Scientific Research|Hospices Civils de Lyon|Inserm|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|Inserm|French National Centre for Scientific Research|University of Gothenburg|Fondation Neurodis|Hospices Civils de Lyon|Hospices Civils de Lyon|Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé|Inserm|French National Centre for Scientific Research|Centre d'Exploration et de Recherche Médicale par Emission de Positons|Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé|Inserm|French National Centre for Scientific Research|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|French National Centre for Scientific Research|Inserm|Hospices Civils de Lyon|Hospices Civils de Lyon|Claude Bernard University Lyon 1|Laboratoire Dynamique du Langage|French National Centre for Scientific Research|French National Centre for Scientific Research|Hospices Civils de Lyon|Lyon Neuroscience Research Center|Claude Bernard University Lyon 1|Inserm
benign childhood epilepsy centrotemporal spikes bcects unique form nonlesional agedependent epilepsy rare seizures focal electroencepalographic abnormalities affecting well delineated cortical region patients frequent mild moderate cognitive dysfunctions condition hypothesized interictal electroencepalographic discharges might interfere local brain maturation resulting altered cognition diffusion tensor imaging allows testing hypothesis investigating white matter microstructure previously proved sensitive epilepsyrelated alterations fractional anisotropy diffusivity however diffusion tensor imaging study yet performed focus bcects investigated 25 children suffering bcects 25 agematched control subjects using diffusion tensor imaging 3dt1 magnetic resonance imaging battery neuropsychological tests including conners scale wechsler intelligence scale children fourth revision electroencephalography also performed patients within 2 months magnetic resonance imaging assessment parametric maps fractional anisotropy mean radial axial diffusivity extracted diffusion tensor imaging data patients compared control subjects using voxelbased statistics familywise error correction multiple comparisons patient also compared control subjects fractional anisotropy diffusivity images correlated neuropsychological clinical variables group analysis showed significantly reduced fractional anisotropy increased diffusivity patients compared control subjects predominantly left pre postcentral gyri ipsilateral electroencephalographic focus individual level regions significant differences observed 10 patients 40 anisotropy eight reduced fractional anisotropy one increased fractional anisotropy one 17 56 diffusivity 13 increased one reduced three significant negative correlations fractional anisotropy maps duration epilepsy precentral gyri bilaterally left postcentral gyrus accordingly 9 12 patients 75 duration epilepsy12 months showed significantly reduced fractional anisotropy versus none 13 patients duration epilepsy12 months diffusivity maps positively correlated duration epilepsy cuneus children bcects demonstrate alterations microstructure white matter undetectable conventional magnetic resonance imaging predominating regions displaying chronic interictal epileptiform discharges association observed diffusion tensor imaging changes duration epilepsy cognitive performance appears compatible hypothesis interictal epileptic activity alters brain maturation could turn lead cognitive dysfunction however crosssectional association demonstrate causality hitherto unidentified factors could represent common cause part observed findings