S. K. Bhargava|Harshpal Singh Sachdev|Caroline H.D. Fall|Clive Osmond|Lakshmy Ramakrishnan|D. J. P. Barker|Subrata Biswas|Siddharth Ramji|Dorairaj Prabhakaran|K. Srinath Reddy
Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood
Sunder Lal Jain Hospital|Maulana Azad Medical College|Southampton General Hospital|Medical Research Council|University of Southampton|Southampton General Hospital|Medical Research Council|University of Southampton|All India Institute of Medical Sciences|Southampton General Hospital|Medical Research Council|University of Southampton|Indian Council of Medical Research|Maulana Azad Medical College|All India Institute of Medical Sciences|All India Institute of Medical Sciences
risk type 2 diabetes mellitus increased people low birth weights subsequently become obese adults whether obesity originates childhood age unknown understanding origin obesity may especially important developing countries type 2 diabetes rapidly increasing yet public health messages still focus reducing childhood undernutritionwe evaluated glucose tolerance plasma insulin concentrations 1492 men women 26 32 years age measured birth intervals three six months throughout infancy childhood adolescence prospective populationbased studythe prevalence impaired glucose tolerance 108 percent diabetes 44 percent subjects impaired glucose tolerance diabetes typically low bodymass index age two years followed early adiposity rebound age infancy body mass starts rise accelerated increase bodymass index adulthood however despite increase bodymass index ages 2 12 years none subjects obese age 12 years odds ratio disease associated increase bodymass index 1 sd 2 12 years age 136 95 percent confidence interval 118 157 p0001there association thinness infancy presence impaired glucose tolerance diabetes young adulthood crossing higher categories bodymass index age two years also associated disorders