Steve M. Taylor|Jane P. Messina|Carla Cerami Hand|Jonathan J. Juliano|Jérémie Muwonga|Antoinette Tshefu|Benjamin Atua|Michael Emch|Steven R. Meshnick
Molecular Malaria Epidemiology: Mapping and Burden Estimates for the Democratic Republic of the Congo, 2007
Duke Medical Center|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|Programme National Multisectoriel de Lutte contre le sida|University of Kinshasa|Programme National Multisectoriel de Lutte contre le sida|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill
background epidemiologic data malaria scant many highburden countries including democratic republic congo drc suffers secondhighest global burden malaria malaria control efforts regions challenging infrastructure require reproducible efficient surveillance employed new highthroughput molecular testing characterize state malaria control drc estimate childhood mortality attributable excess malaria transmission methods findings demographic health survey crosssectional populationbased cluster household survey adults aged 1559 years 2007 employing structured questionnaires dried blood spot collection parasitemia detected realtime pcr survey responses measured adoption malaria control measures under5 health indices response rate 99 household level 8886 households surveyed 300 clusters 8838 respondents molecular results available overall prevalence parasitemia 335 95 confidence interval ci 32349 p falciparum prevalent species either monoinfection 904 95 ci 888921 combined p malariae 49 95 ci 3759 p ovale 06 95 ci 0109 77 95 ci 6886 households children 5 owned insecticidetreated bednet itn 68 95 ci 6175 underfives slept itn preceding night overall under5 mortality rate 147 deaths per 1000 live births 95 ci 141153 clusters associated increased p falciparum prevalence based population attributable fraction 26488 yearly under5 deaths attributable excess malaria transmission conclusions adult p falciparum prevalence substantial drc associated under5 mortality molecular testing offers new generalizable efficient approach characterizing malaria endemicity underserved countries