Mirian Elizabeth Muñoz Quispe, Michaell Jeremy Mendoza Cóndor, Jorge Enrique Cahuana Vílchez, Manuel Antonio Mattos-Vela
[Deaf people and sign language: an enigma in dentistry]
Revista cientifica odontologica (Universidad Cientifica del Sur)
hptn 083 demonstrated superiority longacting cabotegravir cabla versus daily oral emtricitabinetenofovir disoproxil fumarate tdfftc preexposure prophylaxis prep among cisgender men transgender women sex men msmtgw hptn 083 provided first opportunity understand experiences injectable prep clinical trial participants two us sites chicago il atlanta ga one international site rio de janeiro brazil purposively sampled individual qualitative interviews n 40 november 2019 march 2020 explore trial experiences barriers adherence factors may impacted study implementation outcomes blinded phase ended early due efficacy analysis includes interviews conducted prior unblinding three groups defined adherence ie injection visit attendance adherent n 27 nonadherent n 12 early discontinuers n 1 data organized using nvivo software analysed using content analysis participants mean age 27 primarily cisgender msm 90 blackafrican american 60 reasons trial enrolment prep use included preference using hiv prevention medication versus treatment event hiv acquisition ability enhance health via studyrelated education services access novel convenient hiv prevention product cost contributing msmtgw communities research participants contrasted positive experiences study staff routine clinical care emphasized increased scheduling flexibility thorough communication nonjudgemental counselling open affirming environments eg compassion less stigma adherence facilitators injection experiences positive overall described early injectionrelated anxiety abated time given measure control eg preinjection countdown minimal injection site discomfort concerns misperceptions injectable prep reported barriers adherence across adherence categories included structural factors eg financial constraints travel competing demands eg work schedules respondents viewed injectable prep trial participation positive experience means enhancing wellbeing study site flexibility affirming clinic environments inclusive nonjudgemental counselling key facilitators adherence support injection persistence interventions address structural barriers promote flexible means injection delivery may effective