Emily Duncanson, Christopher E Davies, Shyamsundar Muthuramalingam, Effie Johns, Kate McColm, Matty Hempstalk, Zoran Tasevski, Nicholas A Gray, Stephen P McDonald
Patient Perspectives of Center-Specific Reporting in Kidney Failure Care: An Australian Qualitative Study
Kidney international reports
exposure therapy evidencebased treatment option anxietyrelated disorders many patients also take medication could principle affect exposure therapy efficacy clinical laboratory evidence indeed suggests benzodiazepines may detrimental effects large clinical trials propranolol common betablocker currently lacking several preclinical studies indicate impaired establishment safety memories investigated effects propranolol given prior extinction training 9 rat studies n 215 one human study n 72 bayesian metaanalysis rat studies provided strong evidence propranololinduced extinction memory impairment drugfree test human study found significant difference placebo two rat studies actually suggested small beneficial effect propranolol lastly two rat studies benzodiazepine midazolam group provided evidence harmful effect extinction memory ie impaired extinction retention conclusion midazolam findings line prior literature ie extinction retention impairment case 10 studies propranolol data thus support caution regarding use benzodiazepines exposure therapy argue harmful effect propranolol extinction learning