Vesna Vucelić, Vesna Bratić, Dubravka Negovetić Vranić, Arjana Tambić Andrašević, Vesna Degoricija, Zlatan Mihaljević, Snježana Ramić, Ivana Piteša Košutić, Luka Šimunović, Bruno Špiljak, Vlaho Brailo
Understanding and Practices of Oral Hygiene in the Intensive Care Units: Perspectives of Medical Staff at Two University Hospital Centers
Acta stomatologica Croatica
despite growing literature effectiveness liraglutide weight management among individuals prediabetes preventing disease remains controversial study aims critically evaluate extent liraglutides impact weight management population assess heterogeneity among extant studies systematic literature search conducted across medline embase clinicaltrialsgov reference list retrieved studies identify eligible english language randomized controlled trials rcts evaluating liraglutides effect weight individuals prediabetes nonrandomized studies studies reporting relevant outcomes conducted patients type 2 diabetes excluded review outcomes included change baseline absolute body weight kg body mass index bmi waist circumference glycosylated hemoglobin hba1c lowdensity lipoprotein cholesterol ldlc levels additional safety outcomes also reported data analyzed using r statistical software version 431 fixedeffect model used pooling crude numbers study outcomes moreover sensitivity analysis using randomeffect model performed heterogeneity assessed using i2 statistics five eligible studies included total 1604 subjects liraglutide arm 859 subjects control arm participants exposed liraglutide showed decrease body weight md 495 kg 95ci 516 473 i2 93 bmi md 206 kgm2 95ci 222 189 i2 97 waist circumference md 461 cm 95ci 479 443 i2 82 hba1c md 033 95ci 034 031 i2 100 ldlc levels md 036 mmoll 95ci 039 033 i2 99 overall effect size remained similar using randomeffects model outcomes addition rate adverse events higher liraglutide compared control however dropout rates relatively lower former arm metaanalysis suggests liraglutide reduce body weight bmi waist circumference hba1c levels prediabetic individuals findings interpreted cautiously due limitations small number trials studys short duration variability dosages randomized controlled trials examining longterm outcomes essential validate findings address high heterogeneity among studies included analysis