Zelalem Asmare, Mulat Erkihun, Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Sefineh Fenta Feleke
Catheter-associated urinary tract infections in Africa: Systematic review and meta-analysis
Infection, disease & health
developmental disorders dds autism spectrum disorder asd incorporate various conditions identified diagnostics necessary specify type severity aim exploratory study identify genetic variants help differentiate asd early dds selected 36 children mean age 601 months dds using developmental behavioral scales dbs eduseducation organization providing services children developmental disorders bosnia herzegovina rated childrens autistic traits preschool version childhood autism rating scale second edition carsii defined asd scores 255 dds scores 255 diagnosis asd dd independently confirmed child psychiatrists whole exome sequencing wes performed veritas genetics usa using illumina novaseq 6000 illumina inc san diego ca usa nextgeneration sequencing ngs apparatus tested genetic association applying skato optimally combines standard sequence kernel association test skat burden tests identify rare variants associated complex traits samples limited power analysis yielded seven genes dse col10a1 dlk2 csmd1 fam47e ppia pydc2 potentially differentiate observed phenotypic characteristics cohort participants asd dds exploratory study small sample participants asd dds contributed gene discovery differentiating asd dds replication study needed larger sample confirm results