Bettina Meiser|Veronica Collins|Rosemary Warren|Clara Gaff|D. H. St John|Mary Young|K Harrop|Johnny E. Brown|Jane Halliday
Psychological impact of genetic testing for hereditary non?polyposis colorectal cancer
Prince of Wales Hospital|Royal Children's Hospital|Murdoch Children's Research Institute|Royal Children's Hospital|Murdoch Children's Research Institute|Royal Children's Hospital|Royal Melbourne Hospital|Royal Ottawa Mental Health Centre|Royal Melbourne Hospital|Peter MacCallum Cancer Centre|Princess Margaret Hospital for Children|University of Melbourne|Royal Children's Hospital|Murdoch Children's Research Institute
psychological impact predictive genetic testing hereditary nonpolyposis colorectal cancer hnpcc assessed 114 individuals 32 carriers 82 noncarriers attending familial cancer clinics using mailed selfadministered questionnaires prior 2 weeks 4 months 12 months carrier status disclosure compared baseline carriers showed significant increase mean scores intrusive avoidant thoughts colorectal cancer 2 weeks 249 p 0014 significant decrease mean depression scores 2 weeks postnotification result 398 p 0001 4 months postnotification result 322 p 0002 noncarriers significant decreases mean scores intrusive avoidant thoughts colorectal cancer observed followup assessment time points relative baseline noncarriers also showed significant decreases baseline mean depression scores 2 weeks 4 months 12 months postnotification significant decreases baseline mean state anxiety scores also observed noncarriers 2 weeks postnotification 399 p 0001 data indicate predictive genetic testing hnpcc leads psychological benefits amongst noncarriers adverse psychological outcomes observed amongst carriers