Tania Gibbie|Anne Mijch|Steven Ellen|Jennifer Hoy|Colin A. Hutchison|Edwina Wright|Phyllis Chua|Fiona Judd
Depression and neurocognitive performance in individuals with HIV/AIDS: 2?year follow?up
Monash University|The Alfred Hospital|The Alfred Hospital|Monash University|Monash University|The Alfred Hospital|The Alfred Hospital|Monash University|Monash University|Monash University|The Alfred Hospital|Monash University|Monash University
objectives aims study follow cohort hivinfected individuals 2 years assess changes depression neuropsychological performance time explore relationship depression hiv illness neuropsychological performance examine natural history effect highly active antiretroviral therapy haart depression neurocognitive performance methods hivseropositive outpatients assessed baseline 2year followup assessment patients assessed depression using beck depression inventory bdi structured clinical interview scidcv completed battery neuropsychological tests including cambridge neuropsychological test automated battery cantab hopkins hiv dementia scale hds results baseline 348 scored 14 bdi 14 suggests depressive symptoms ds scidcv revealed 27 participants met criteria current mood disorder seven per cent participants scores hds indicated hivassociated cognitive changes eighty participants retested 2year followup split two groups based bdi scores baseline cantab results revealed cohort significantly impaired nine 10 measures compared agematched normative data neurocognitive performance significantly improved participants ds baseline whereas participants ds baseline show much improvement multivariate analysis revealed 40 change cognitive performance attributable variables age aids haart regimen conclusion results suggest significant decline depression scores improvement several neurocognitive domains time relationship hiv illness haart symptoms depression neurocognitive performance