Sara M Hiebert
The strong-inference protocol: not just for grant proposals
Advances in physiology education
recreational use nitrous oxide n2o associated development severe nitrous oxideinduced neuropathy n2on followup patients poses challenges clinical progression remains largely unknown identification prognostic factors made difficult lack standardized longitudinal assessments studies objective document course neuropathy systematic followup assessments n2on patients identify prognostic factors persistent disability 6 months gathered demographic clinical biological electrophysiological data n2on patients hospitalized referral center marseille baseline standardized followup assessment 6 months retrospectively included 26 n2on patients mean age 226 44 significant improvements observed main clinical scores including rankin onls mrc testing p 01 electrophysiological studies edx revealed predominantly motor neuropathy marked reduction cmap lower limbs baseline significant improvement motor parameters p 543 rankin score 6 months correlated initial weekly n2o consumption r 43 p 03 cmap sum score lower limbs first edx r 47 p 02 patients without myelitis showed similar rankin onls score 6 months clinical course generally improved favorably 6 months notable amelioration primary disability scores sensory deficits ataxia however distal motor impairment associated peripheral neuropathy persisted distal axonal loss emerging main prognostic factor longterm disability young patients