Amaia Carrion?Castillo|Elsje van Bergen|Arianna Vino|Titia L. van Zuijen|Peter F. de Jong|Clyde Francks|Simon E. Fisher
Evaluation of results from genome?wide studies of language and reading in a novel independent dataset
Max Planck Institute for Psycholinguistics|Vrije Universiteit Amsterdam|University of Oxford|Max Planck Institute for Psycholinguistics|University of Amsterdam|University of Amsterdam|Max Planck Institute for Psycholinguistics|Radboud University Nijmegen|Max Planck Institute for Psycholinguistics|Radboud University Nijmegen
recent genomewide association scans gwas reading language abilities pinpointed promising new candidate loci however potential contributions loci remain validated study tested 17 significantly associated single nucleotide polymorphisms snps gwas studies p 106 original studies new independent population dataset netherlands known familial influences literacy abilities dataset comprised 483 children 307 nuclear families 505 adults including parents participating children provided adequate statistical power detect effects previously reported following measures reading language performance collected word reading fluency nonword reading fluency phonological awareness rapid automatized naming two snps rs12636438 rs7187223 associated performance multivariate univariate testing remain significant correction multiple testing another snp rs482700 nominally associated multivariate test rest snps find supportive evidence association findings may reflect differences study previous investigations respect language testing exact tests used recruitment criteria alternatively prior reported associations may false positives larger scale gwas metaanalysis previously performed likely required obtain robust insights genomic architecture underlying reading language