Matthew P Fox, Roch Nianogo, Jacqueline E Rudolph, Chanelle J Howe
Illustrating How to Simulate Data From Directed Acyclic Graphs to Understand Epidemiologic Concepts
American journal of epidemiology
rare cancers exhibit incidence less six per 100000 year average fiveyear relative survival patients rare cancers worse common cancers traumatic experience cancer intensified patients rare cancers due limited clinical evidence lack empirical evidence informed decisionmaking rare cancers cumulatively accounting 25 cancers coupled rising burden rare cancers societies globally necessary determine psychological outcomes patients rare cancers prismaadherent systematic review prospero crd42023475748 involved systematic search pubmed embase cochrane psycinfo peerreviewed english language studies published since 2000 30th january 2024 evaluated prevalence incidence risk depression anxiety suicide posttraumatic stress disorder ptsd patients rare cancers two independent reviewers appraised extracted summary data published studies random effects metaanalyses metaregression used primary analysis included 32 studies 57470 patients rare cancers metaanalyses indicated statistically significant increased riskratio rr depression rr 261 95 ci 143477 i2 97 anxiety rr 266 95 ci 127555 i2 92 patients rare cancers compared healthy controls identified high suicide incidence 315 per 100000 personyears 95 ci 162609 i2 95 prevalence depression 17 95 ci 1422 i2 88 anxiety 20 95 ci 1525 i2 96 ptsd 18 95 ci 932 i2 25 compared patients common cancer types suicide incidence ptsd prevalence significantly higher patients rare cancers systematic review found advanced disease chemotherapy treatment lower income social status risk factors negative psychological outcomes highlight need early identification psychological maladjustment patients rare cancers additionally studies identify effective interventions imperative study supported national medical research council transition award singhealth dukenus oncology academic clinical programme khoo pilot collaborative award national medical research council clinician scientistindividual research grantnew investigator grant terry fox grant khoo bridge funding award