Bárbara Riegel|Stephen T. Moelter|Sarah J. Ratcliffe|Susan J. Pressler|Sabina De Geest|Sheryl Potashnik|Desiree Fleck|Daohang Sha|Steven L. Sayers|William S. Weintraub|Terri E. Weaver|Lee R. Goldberg
Excessive Daytime Sleepiness is Associated With Poor Medication Adherence in Adults With Heart Failure
University of Pennsylvania|University of the Sciences|Philadelphia University|University of Pennsylvania|University of Michigan–Ann Arbor|KU Leuven|University of Basel|University of Pennsylvania|Hospital of the University of Pennsylvania|Philadelphia University|University of Pennsylvania|University of Pennsylvania|Christiana Care Health System|University of Illinois Urbana-Champaign|University of Illinois at Chicago|University of Pennsylvania
background relationship excessive daytime sleepiness eds poor treatment adherence suspected confirmed hypothesized medication adherence would poorer adults heart failure hf eds cognitive status would mechanism effect methods results sample 280 adults chronic hf enrolled prospective cohort comparison study identified cohort eds control group without eds divided groups without mild cognitive decline data medication adherence obtained baseline 3 6 months using basel assessment adherence scale regression analysis used clarify contribution eds cognition medication adherence assess relationships 6 months adjusting age enrollment site gender race functional class depression premorbid intellect baseline 62 subjects nonadherent medication regime nonadherence significantly common eds regardless cognitive status p 035 odds nonadherence increased 11 unit increase eds adjusted odds ratio 111 95 confidence interval 105119 p 001 longitudinal models 10 increase odds nonadherence unit increase eds p 008 cognition measure significantly associated medication adherence attention p 047 conclusions adults hf eds likely problems adhering medication regimen without eds regardless cognitive status identifying correcting factors interfere sleep may improve medication adherence