Juliane Callegaro Borsa, Nelson Hauck-Filho, Bruno Figueiredo Damásio
Proactive and Reactive Aggressive Behaviors: Dimensionality of Self-Report Scales
The Spanish journal of psychology
qualitative interactions occur treatment effect measure association varies sign subpopulation particular interest many biomedical settings absencepresence qualitative interactions occur effect present one subpopulation absent another absencepresence interactions arise emerging applications precision medicine objective identify set predictive biomarkers prognostic value clinical outcomes subpopulation others also arise naturally gene regulatory network inference goal identify differences networks corresponding diseased healthy individuals different subtypes disease differences lead identification networkbased biomarkers diseases paper argue absencepresence hypothesis important developing statistical test hypothesis intractable problem overcome challenge approximate problem novel inference framework particular propose make inferences absencepresence interactions quantifying relative difference effect size reasoning relative difference large absencepresence interaction occurs proposed methodology illustrated simulation study well analysis breast cancer data cancer genome atlas