Qiqi Ji, Lin Zhang, Jiashuang Xu, Pengjuan Ji, Miaojing Song, Yian Chen, Leilei Guo
Associations of mental well-being with higher education-related stress and orientation of the academic goals among nursing students: A cross-sectional study
International journal of mental health nursing
diffusion kurtosis imaging dki neurite orientation dispersion density imaging noddi provide comprehensive informative perspective microstructural alterations cerebral white matter wm singleshell diffusion tensor imaging dti especially detection crossing fiber however studies systemic lupus erythematosus patients without neuropsychiatric symptoms nonnpsle patients using multishell diffusion imaging remain scarce totally 49 nonnpsle patients 41 age sex educationmatched healthy controls underwent multishell diffusion magnetic resonance imaging totally 10 diffusion metrics based dki fractional anisotropy mean diffusivity axial diffusivity radial diffusivity mean kurtosis axial kurtosis radial kurtosis noddi neurite density index orientation dispersion index volume fraction isotropic diffusion compartment evaluated tractbased spatial statistics tbss atlasbased regionofinterest roi analyses performed determine group differences brain wm microstructure associations multishell diffusion metrics clinical indicators determined investigation tbss analysis revealed reduced fa ad rk increased odi wm nonnpsle patients p 005 familywise error corrected odi showed best discriminative ability atlasbased roi analysis found increased odi values anterior thalamic radiation atr inferior frontaloccipital fasciculus ifof forceps major fmajor forceps minor fminor uncinate fasciculus uf nonnpsle patients right atr showed best discriminative ability odi fmajor positively correlated c3 study suggested dki noddi metrics complementarily detect wm abnormalities nonnpsle patients revealed odi sensitive specific biomarker dki guiding understanding pathophysiological mechanism normalappearing wm injury sle