Aregawi Gebreyesus, Asqual Gebreslassie Gebremariam, Kokob Gebru Kidanu, Solomon Gidey, Hansa Haftu, Afewerki Tesfahunegn Nigusse, Fiyori Shishay, Liya Mamo
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current diagnostic criteria adrenocortical neoplasms mostly based morphology utility immunohistochemistry ihc histochemistry limited evaluate diagnostic prognostic utility clinicopathological features morphology ancillary biomarkers reticular histochemistry adrenocortical neoplasms examined 28 adrenocortical carcinomas accs 50 adrenocortical adenomas acas obtained pathology archives clinical data retrieved medical records two pathologists independently assessed hematoxylin eosinstained slides employing modified weiss criteria tumors linweissbisceglia criteria oncocytic variants immunohistochemical markers calretinin alphainhibin melana sf1 ki67 phh3 igf2 catenin p53 cyp11b1 cyp11b2 mlh1 msh2 msh6 pms2 epcam gomoris silver histochemistry applied statistical analysis utilized spss statistics 26 accs exhibited larger tumor sizes p0001 symptomatic presentations p 0031 compared acas parameters modified weiss criteria angioinvasion demonstrated diagnostic value accs six immunohistochemical antibodiesmelana ki67 igf2 catenin p53 cyp11b1 reticulin framework alterations showed diagnostic value notably ki67 reticulin staining recommended evident reticulin staining frequently present accs p0001 ki67 significantly higher accs p0001 twentyone conventional seven oncocytic entities showed different necrosis frequencies symptoms ki67 index 30 prognostic accs correlating shorter survival study emphasizes diagnostic value reticulin framework alterations high ki67 index markers cyp11b1 igf2 p53 catenin melana also contribute diagnosis accs symptoms ki67 index 30 predict shorter survival findings encourges use ancillary markers reticulin histochemistry ki67 workup evaluations adrenocortical neoplasms