Hayley A Braun, Christi M Kay, Patricia Cheung, Paul S Weiss, Julie A Gazmararian
Impact of an Elementary School-Based Intervention on Physical Activity Time and Aerobic Capacity, Georgia, 2013-2014
Public health reports (Washington, D.C. : 1974)
investigate effect chronic hyperglycemia hypoglycemia diabetic ketoacidosis dka cognitive function children adolescents type 1 diabetes mellitus t1dm explore whether early disease onset correlated cognitive impairment children adolescents t1dm attended pediatric diabetes clinic january 2019 2020 aged 514 years mean 3 glycated hemoglobin hba1c readings 7 53 mmolmol study period reflecting hyperglycemic status agreed participate interviewed history hypoglycemia dka participants personally interviewed clinical psychologist assess cognitive function using validated arabic version stanfordbinet test higher mean hba1c levels associated cognitive dysfunction three verbal domains fluid reasoning quantitative reasoning working memory frequent hypoglycemia negatively affected verbal knowledge contrast significant hypoglycemia affected verbal nonverbal domains cognition specifically verbal nonverbal fluid reasoning knowledge working memory children recurrent dka performed average nonverbal fluid reasoning tasks additionally moderate severe dka regardless frequency affected childrens overall intelligence quotient regardless disease onset exposure glycemic variability subjects children adolescents subtle measurable cognitive dysfunction resulting significant morbidity