Simon E. Fisher|Claudia K. Y. Lai|Anthony P. Monaco
DECIPHERING THE GENETIC BASIS OF SPEECH AND LANGUAGE DISORDERS
Wellcome Centre for Human Genetics|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford
significant number individuals unexplained difficulties acquiring normal speech language despite adequate intelligence environmental stimulation although developmental disorders speech language heritable genetic basis likely involve several possibly many different risk factors investigations unique threegeneration family showing monogenic inheritance speech language deficits led isolation first gene chromosome 7 encodes transcription factor known foxp2 disruption gene causes rare severe speech language disorder appear involved common forms language impairment recent genomewide scans identified least four chromosomal regions may harbor genes influencing latter chromosomes 2 13 16 19 molecular genetic approach potential dissecting neurological pathways underlying speech language disorders investigations beginning