Elfitra Desifatma, Prihandhanu Mukti Pratomo, Enjang Jaenal Mustopa, Wahyu Srigutomo
VLF-EM data conversion into apparent resistivity using the Hilbert transform and its application for shallow fault investigation at Pinggirsari, Bandung Regency, Indonesia
Heliyon
exercise profound effect insulin sensitivity skeletal muscle euglycaemichyperinsulinaemic clamp ehc gold standard assessment insulin sensitivity reflect hyperglycaemia occurs eating meal previous ehc investigations shown interstitial glucose concentration muscle decreased larger extent previously exercised muscle rested muscle suggests previously exercised muscle may increase glucose uptake rested muscle glucose supply increased hyperglycaemia therefore hypothesised exerciseinduced increase muscle insulin sensitivity would appear greater eating meal previously observed ehc ten recreationally active men performed dynamic onelegged knee extensor exercise 1 h following femoral veins one femoral artery cannulated subsequently 4 h exercise solid meal followed two liquid meals ingested 1 h glucose uptake two legs measured 3 h muscle biopsies legs obtained meal test 90 min meal test initiated data obtained previous studies using ehc n106 participants 13 ehc studies used comparison mealtest data obtained study plasma glucose insulin peaked 45 min initiation meal test following meal test leg glucose uptake glucose clearance increased twice much exercised leg rested leg difference twice big observed previous investigations using ehcs glucose uptake rested leg plateaued 15 min alongside elevated muscle glucose 6phosphate levels suggestive compromised muscle glucose metabolism contrast glucose uptake exercised leg plateaued 45 min initiation meal test signs compromised glucose metabolism phosphorylation tbc1 domain family member 4 tbc1d4 ptbc1d4ser704 glycogen synthase activity greater exercised leg compared rested leg muscle interstitial glucose concentration increased ingestion meals although 16 lower exercised leg rested leg hyperglycaemia meal ingestion results larger differences muscle glucose uptake rested exercised muscle previously observed ehcs findings indicate ability exercise increase insulinstimulated muscle glucose uptake even greater evaluated meal test previously shown ehcs