Kartik K. Venkatesh|Laura E. Riley|Víctor M. Castro|Roy H. Perlis|Anjali J. Kaimal
Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth
Center for Human Genetics|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital|Center for Human Genetics|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital|Center for Human Genetics|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital|Center for Human Genetics|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital|Center for Human Genetics|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital
evaluate association antenatal depression symptoms preterm birth small gestational age sgathis observational cohort study conducted among women completed edinburgh postnatal depression scale screening delivered 20 weeks gestation greater primary outcomes preterm birth sga neonate birth less 10th percentile gestational age primary predictor edinburgh postnatal depression scale antepartum score 10 greater indicating symptoms depression logistic regression models used without consideration antidepressant exposure pregnancyamong 7267 women 831 11 screened positive depression multivariable analyses adjusting maternal age race income body mass index tobacco use lifetime diagnosis major depression anxiety diabetes hypertension preeclampsia women screened positive depression experienced increased risk preterm birth less 37 weeks gestation adjusted odds ratio 127 95 confidence interval ci 104155 preterm birth less 32 weeks gestation adjusted 182 95 ci 109302 well sga neonate adjusted 128 95 ci 104158 secondary analyses among women treated antidepressant pregnancy 19 screened positive 5 screened negative depressive symptoms associated significantly increased risk preterm preterm birth sga neonatein large cohort women screened depression antepartum depressive symptoms increased likelihood preterm preterm delivery well sga neonate risk apparent among women treated antidepressant medication