Chiara Gasteiger|A. Jones|Maria Kleinstäuber|Maria Lobo|Rob Horne|Nicola Dalbeth|Keith J. Petrie
Effects of Message Framing on Patients’ Perceptions and Willingness to Change to a Biosimilar in a Hypothetical Drug Switch
University of Auckland|University of Auckland|University of Otago|University of Auckland|Auckland District Health Board|University College London|Auckland District Health Board|University of Auckland|University of Auckland
patients often hold negative perceptions toward biosimilars create barriers uptake physicians also report uncertainty best explain biosimilars aim study measure effect differently framed explanations patients perceptions willingness change biosimilar hypothetical drug switchninetysix patients rheumatic diseases taking originator biologic randomized receive 1 4 biosimilar explanations positive framing without analogy negative framing without analogy willingness switch biosimilar perceptions biosimilars effectiveness explanation measured information deliverypositive framing led participants willing switch 67 negative framing 46 framing significantly predicted willingness switch biosimilar participants positive framing group 236 times willing switch p 0041 positive framing group also reported significantly greater perceived efficacy biosimilars p 0046 thought explanation convincing p 0030 analogy enhance willingness switch increase understanding p 005positive framing improve perceptions willingness switch biosimilar patients currently taking biologic treatments