Thomas F. Wierzba|Shantanu Kumar Kar|Vijayalaxmi V. Mogasale|Anna S. Kerketta|Young Ae You|Prameela Baral|Hemant Kumar Khuntia|Mohammad Ali|Yang?Hee Kim|Shyam Bandhu Rath|Anuj Bhattachan|Binod Sah
Effectiveness of an oral cholera vaccine campaign to prevent clinically-significant cholera in Odisha State, India
International Vaccine Institute|Regional Medical Research Center|International Vaccine Institute|Regional Medical Research Center|International Vaccine Institute|Regional Medical Research Center|International Vaccine Institute|International Vaccine Institute|Regional Medical Research Center|International Vaccine Institute|International Vaccine Institute
clinical trial conducted india suggests oral cholera vaccine shanchol provides 65 protection five years clinicallysignificant cholera although vaccine efficacious tested experimental setting policymakers likely use vaccine receiving evidence demonstrating protection delivered communities using local health department staff cold chain equipment logisticswe used testnegative casecontrol design evaluate effectiveness vaccination campaign using shanchol validated results using cohort approach addressed disparities healthcare seeking behavior campaign conducted local health department using existing resources choleraendemic area puri district odisha state india nonpregnant residents one year age older offered vaccine next two years residents seeking care diarrhea one five health facilities asked enroll following informed consent cases patients seeking treatment laboratoryconfirmed v choleraassociated diarrhea controls patients seeking treatment v cholerae negative diarrheaof 51488 eligible residents 31552 individuals received one dose 23751 residents received two vaccine doses identified 44 v cholerae o1associated cases 366 non v cholerae diarrhea controls adjusted protective effectiveness persons receiving two doses 690 95 ci 145 888 similar adjusted estimates obtained cohort approach statistical trend test suggested single dose provided modicum protection 33 test trend p00091this vaccine found efficacious results reported clinical trial administered rural population using local health personnel resources study provides evidence vaccine widely deployed public health departments cholera endemic areas