Sateesh B Arja, Bobbie Ann White, Jabeen Fayyaz, Anne Thompson
The impact of accreditation on continuous quality improvement process in undergraduate medical education programs: A scoping review
MedEdPublish (2016)
heterogeneity white matter damage symptoms concussion identified major obstacle therapeutic innovation contrast diffusion mri dmri studies concussion traditionally relied groupcomparison approaches average heterogeneity leverage rather average concussion heterogeneity combined dmri multivariate statistics characterize multitract multisymptom relationships using crosssectional data 306 previously concussed children aged 910 adolescent brain cognitive development study built connectomes weighted classical emerging diffusion measures measures combined two informative indices first representing microstructural complexity second representing axonal density deployed patternlearning algorithms jointly decompose connectivity features 19 symptom measures early multitract multisymptom pairs explained covariance represented broad symptom categories general problems pair pair representing cognitive symptoms implicated distributed networks white matter tracts pairs represented specific symptom combinations pair representing attention problems exclusively associated localized white matter abnormalities symptom representation systematically related tract representation across pairs sleep problems implicated across pairs related different connections across pairs expression multitract features driven sociodemographic injuryrelated variables well clinical subgroups defined presence adhd analyses performed replication dataset showed consistent results using doublemultivariate approach identified clinicallyinformative crossdemographic multitract multisymptom relationships results suggest rather clear onetoone symptomconnectivity disturbances concussions may characterized subtypes symptomconnectivity relationships symptomconnectivity relationships identified multitract multisymptom pairs apparent singletractsinglesymptom analyses future studies aiming better understand connectivitysymptom relationships take account multitract multisymptom heterogeneity financial support work came vanier canada graduate scholarship canadian institutes health research gig ontario graduate scholarship ss restracomp research fellowship provided hospital sick children ss institutional research chair neuroinformatics md well natural sciences engineering research council create grant md