Deborah Watson?Jones|Kathy Baisley|Helen A. Weiss|Clare Tanton|John Changalucha|Dean Everett|Tobias Chirwa|David A. Ross|Tim Clayton|Richard Hayes
Risk factors for HIV incidence in women participating in an HSV suppressive treatment trial in Tanzania
London School of Hygiene & Tropical Medicine|Amref Health Africa|London School of Hygiene & Tropical Medicine|National Institute for Medical Research|London School of Hygiene & Tropical Medicine|London School of Hygiene & Tropical Medicine|National Institute for Medical Research|National Institute for Medical Research|London School of Hygiene & Tropical Medicine|National Institute for Medical Research|London School of Hygiene & Tropical Medicine|National Institute for Medical Research|London School of Hygiene & Tropical Medicine|London School of Hygiene & Tropical Medicine|London School of Hygiene & Tropical Medicine
objectives randomized doubleblind placebocontrolled trial rct herpes simplex virus type 2 suppressive therapy acyclovir 400 mg twice daily conducted among women northwestern tanzania reported similar rate hiv acquisition trial arms current controlled trials number isrctn35385041 risk factors hiv incidence examined context 3monthly followup visits offering voluntary counselling testing care sexually transmitted infections design prospective cohort analysis trial participants enrolled followed 30 months methods risk factors hiv acquisition analysed using cox regression results overall 821 herpes simplex virus type 2 seropositive hiv seronegative women randomized 400 randomized acyclovir 421 placebo 659 803 completed followup hiv incidence 427 per 100 personyears overall impact acyclovir hiv incidence hazard ratio 101 95 confidence interval ci 061166 hiv acquisition independently associated younger age enrolment age 1619 vs 3035 hazard ratio 402 95 ci 167968 alcohol consumption enrolment 30 drinksweek vs none hazard ratio 439 95 ci 1701133 paid sex within previous 3 months hazard ratio 182 95 ci 109305 recent infection gonorrhoea hazard ratio 362 95 ci 162808 injections previous 3 months hazard ratio 345 95 ci 162734 evidence association hiv incidence living recruitment community less 2 years hazard ratio 175 95 ci 098310 exposure hormonal contraception hazard ratio 160 95 ci 093276 conclusion high incidence hiv observed trial cohort especially young women interventions needed address risk associated alcohol use sustain control sexually transmitted infections