Gerry Leisman, Raed Mualem, Calixto Machado
The Integration of the Neurosciences, Child Public Health, and Education Practice: Hemisphere-Specific Remediation Strategies as a Discipline Partnered Rehabilitation Tool in ADD/ADHD
Frontiers in public health
social health markers including marital status contact frequency network size social support shown associated cognition however mechanisms underlying associations remain poorly understood investigated whether depressive symptoms inflammation mediated associations social health subsequent cognition english longitudinal study ageing elsa nationally representative longitudinal study england uk sampled 7136 individuals aged 50 years older living private households without dementia baseline intermediate mediator assessment timepoint recorded information least one social health marker potential mediator used fourway decomposition examine extent depressive symptoms creactive protein fibrinogen mediated associations social health subsequent standardised cognition verbal fluency delayed immediate recall including cognitive change slopes derived multilevel models 12year slope examined whether findings replicated swedish national study aging care kungsholmen snack populationbased longitudinal study sweden sample 2604 individuals aged 60 years older living home institutions kungsholmen central stockholm without dementia baseline intermediate mediator assessment timepoint 6year slope social health exposures assessed baseline potential mediators assessed intermediate timepoint wave 2 elsa 6year followup snack cognitive outcomes assessed single timepoint wave 3 elsa 12year followup snack cognitive change waves 3 9 elsa 6year 12year followups snack study sample included 7136 participants elsa 3962 555 women 6934 972 white mean baseline age 638 years sd 94 replication analyses included 2604 participants snack 1604 616 women snack collect ethnicity data mean baseline age 723 years sd 101 elsa found indirect effects via depressive symptoms network size positive support less negative support subsequent verbal fluency positive support subsequent immediate recall pure indirect effect pie 0002 95 ci 00010003 depressive symptoms also partially mediated associations less negative support slower decline immediate recall pie 0001 00000002 delayed recall pie 0001 00000002 positive support slower decline immediate recall pie 0001 00000001 observe mediation inflammatory biomarkers findings mediation depressive symptoms association positive support verbal fluency positive support change immediate recall replicated snack findings study provide new insights mechanisms linking social health cognition suggesting associations interactional aspects social health especially social support cognition partly underpinned depressive symptoms eu joint programmeneurodegenerative disease research jpnd alzheimers society swedish translation abstract see supplementary materials section