Harald Bugmann, Rupert Seidl, Florian Hartig, Friedrich Bohn, Josef Brůna, Maxime Cailleret, Louis François, Jens Heinke, Alexandra-Jane Henrot, Thomas Hickler, Lisa Hülsmann, Andreas Huth, Ingrid Jacquemin, Chris Kollas, Petra Lasch-Born, Manfred J Lexer, Ján Merganič, Katarína Merganičová, Tobias Mette, Brian R Miranda, Daniel Nadal-Sala, Werner Rammer, Anja Rammig, Björn Reineking, Edna Roedig, Santi Sabaté, Jörg Steinkamp, Felicitas Suckow, Giorgio Vacchiano, Jan Wild, Chonggang Xu, Christopher P O Reyer
Tree mortality submodels drive simulated long-term forest dynamics: assessing 15 models from the stand to global scale
Ecosphere (Washington, D.C)
interventions promote adaptive emotion regulation er skills reduce pain patients chronic pain however whether effects yoga practice chronic low back pain clbp due improvements er remains examined study test whether effects yoga clbp improved pain severity interference mediated improved er extent effects related specific aspects er role pain sensitization mediator moderator effects study pain sensitization assessed quantitative sensory testing gene expression profiles examine whether pain sensitization moderates yogas effects pain whether yoga er abilities reduce pain sensitization leading decreased pain severity interference 2arm parallel group blinded randomized controlled trial enroll 204 adults clbp randomized receive yoga n102 control stretching strengthening n102 intervention delivered via webbased synchronous biweekly 75minute sessions 12 weeks participants encouraged practice postures exercises 25 minutes days using accessible prerecorded practice videos sent participants digitally participants assessed 5 time points baseline midintervention 6 weeks postintervention 12 weeks 3 6month followups assessments er pain severity interference pain sensitivity including somatosensory gene expression profiles physical strength flexibility conducted visit fidelity interventions assessed using manualized checklist evaluate recorded group sessions ensure consistent instructor delivery primary outcome mean change pain severity measured brief pain inventoryshort form 12 weeks primary mechanism action er measured change difficulties emotion regulation scale total score secondary outcomes include pain sensitivity physical strength flexibility pain interference quality life mediation path analysis series moderated mediation path analyses conducted test study hypotheses january 2024 enrolled 138 participants expect study completed may 2025 study provide important data evaluating whether improvements er responsible reduced pain perception pain sensitivity well increased quality life context chronic pain study findings important implications determining mechanism action yoga possibly mindbody interventions nonpharmacological therapies pain management results study inform content delivery measures intervention trials involving yoga modality relieving pain improving function clinicaltrialsgov nct04678297 httpsclinicaltrialsgovstudynct04678297 derr110219656016