Matteo Bussoletti, Dana Castro, Rafika Zebdi, Viviane Matar Touma
Prevalence of depression and protective factors in a population of children aged 8 to 10 years, suffering from specific learning disorders, in a special education and home care service (SESSAD)
L'Encephale
cerebrospinal fluid csf galactomannan adjunctive test central nervous system cns aspergillosis diagnosis unclear diagnostic test characteristics evaluate diagnostic test characteristics csf galactomannan cns aspergillosis systematic review metaanalysis medline embase web science scopus inception 24 february 2023 prospective retrospective studies onegroup twogroup designs using galactomannan assay csf diagnose cns aspergillosis adult andor pediatric cns aspergillosis patients galactomannan testing csf specimens european organization research treatment cancer mycoses study group education research consortium eortcmsgerc diagnostic criteria equivalent quadas2 assessment duplicate bivariate restricted maximumlikelihood estimation randomeffects metaanalysis summarized using forest summary receiveroperator characteristic plots bivariate metaregression models investigate heterogeneity subgroup sensitivity analyses explore subgroup effects methodologic choices prospero registration crd42022296331 funding none included eight studies n342 participants summary estimates csf galactomannan sensitivity specificity 690 95 ci 572787 944 95 ci 828983 respectively using metaregression galactomannan cutoff p038 eortcmsgerc criteria version p048 whether reference standard defined proven probable proven aspergillosis p048 explain observed heterogeneity subgroup effects demonstrated analyzing eortcmsgerc criteria reference standard used eg 2002 versus 2008 definitions whether pediatric patients included diagnostic sensitivity improved using galactomannan cutoff 10 excluding high risk bias onegroup design studies csf galactomannan highly specific insensitive test use component cns aspergillosis diagnosis included studies prospective studies high risk bias study limitations