Soumya Swaminathan|Chandrasekaran Padmapriyadarsini|L. Yoojin|B. Sukumar|S. Iliayas|J. Karthipriya|R. Sakthivel|P. Gomathy|Beena Thomas|Minnie Mathews|Christine Wanke|P. Ramesh Narayanan
Nutritional Supplementation in HIV?Infected Individuals in South India: A Prospective Interventional Study
National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|Tufts University|National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|National Institute of Research in Tuberculosis|Tufts University|National Institute of Research in Tuberculosis
background malnutrition human immunodeficiency virus hivinfected individuals associated faster disease progression higher mortality rates suboptimal response antiretroviral therapy art methods conducted prospective interventional study evaluate effects oral macronutrient supplement among hivinfected adults south india patients attending tuberculosis research centre clinics june 2005 december 2007 baseline nutritional assessment laboratory investigations performed patients 1 center received nutritional counseling standard care whereas patients 2 centers additionally received macronutrient providing 400 cal 15 g protein daily study outcomes changes anthropometry body composition blood chemistry immune status 6 months results total 636 artnaive patients enrolled study 361 completed 6 months followup 282 received supplements 79 received standard care mean age standard deviation sd 317 years mean weight sd 5010 kg 42 male significant increases body weight body mass index midarm circumference fatfree mass body cell mass observed supplement group control group 6 months gains greater patients cd4 cell counts 200 cellsl changes observed lipid levels whereas cd4 cell count decreased control group however adjusting baseline differences changes statistically significantly different groups conclusions macronutrient supplementation result significantly increased weight gain compared standard care including nutritional counseling among patients moderately advanced hiv disease effect supplementation specific subsets patients preserving immune function needs research