Michael D. Murray|Kathleen A. Lane|Sujuan Gao|Rebecca M. Evans|Frederick W. Unverzagt|Kathleen Hall|Hugh C. Hendrie
Preservation of Cognitive Function With Antihypertensive Medications
Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University|Regenstrief Institute|Indiana University – Purdue University Indianapolis
results previous studies white older adults suggest antihypertensive medications preserve cognition assessed longterm effect antihypertensive medications cognitive function community sample african american older adultswe conducted longitudinal surveys clinical assessment cognitive function random sample 2212 communitydwelling african americans 65 years older identified 1900 participants without evidence cognitive impairment baseline 1617 subsequent followup information 946 blood pressure measurements cognitive function measured baseline 2 5 years means scores community screening instrument dementia neuropsychological clinical assessment dementia cognitive impairment prescription nonprescription medication use derived inhome inspection medications participant informant reportsof 1900 participants 288 152 developed incident cognitive impairment using logistic regression control effects age sex education baseline cognitive scores hypertension angina myocardial infarction found antihypertensive medications reduced odds incident cognitive impairment 38 odds ratio 062 95 confidence interval 045084 corresponding analysis using blood pressure measurements subset participants inconclusiveantihypertensive medication use associated preservation cognitive function older african american adults