Luciana Martins Frassetto de Freitas, Delma Perpétua Oliveira de Souza
Prevalence of drug use and family relationships among school adolescents in Cuiabá, MT, Brazil: a cross-sectional study, 2015
Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil
researchers long studied regulatory processes genes uncover functions gene regulatory network analysis one popular approaches understanding processes requiring accurate identification interactions among genes establish gene regulatory network advances genomewide association studies expression quantitative trait loci studies led wealth genomic data facilitating accurate inference genegene interactions however unknown confounding factors may influence interactions making interpretation complicated mendelian randomization mr emerged valuable tool causal inference genetics addressing confounding effects estimating causal relationships using instrumental variables paper propose new statistical method mrggi accurately inferring genegene interactions using mendelian randomization mrggi applies one gene exposure another outcome using causal cissinglenucleotide polymorphisms instrumental variables inversevariance weighted mr model simulations demonstrated mrggis ability control type 1 error maintain statistical power despite confounding effects mrggi performed best compared methods using f1 score dream5 dataset additionally applied yeast genomic data mrggi successfully identified six clusters gene ontology analysis confirmed cluster study performs distinct functional roles gathering genes specific functions findings demonstrate mrggi accurately inferences genegene interactions despite confounding effects real biological environments