David Forman|Catherine de Martel|Charles Lacey|Isabelle Soerjomataram|Joannie Lortet?Tieulent|Laia Bruni|Jérôme Vignat|Jacques Ferlay|Freddie Bray|Martyn Plummer|Silvia Franceschi
Global Burden of Human Papillomavirus and Related Diseases
International Agency For Research On Cancer|International Agency For Research On Cancer|Hull York Medical School|University of York|International Agency For Research On Cancer|International Agency For Research On Cancer|Institut Català d'Oncologia|International Agency For Research On Cancer|International Agency For Research On Cancer|International Agency For Research On Cancer|International Agency For Research On Cancer|International Agency For Research On Cancer
worldwide prevalence infection human papillomavirus hpv women without cervical abnormalities 1112 higher rates subsaharan africa 24 eastern europe 21 latin america 16 two prevalent types hpv16 32 hpv18 14 prevalence increases women cervical pathology proportion severity lesion reaching around 90 women grade 3 cervical intraepithelial neoplasia invasive cancer hpv infection identified definite human carcinogen six types cancer cervix penis vulva vagina anus oropharynx including base tongue tonsils estimates incidence cancers 2008 due hpv infection calculated globally estimated 127 million cancers occurring 2008 610000 population attributable fraction paf 48 could attributed hpv infection paf varies substantially geographic region level development increasing 69 less developed regions world 142 subsaharan africa 155 india compared 21 developed regions 16 northern america 12 australianew zealand cervical cancer paf estimated 100 accounted 530000 869 hpv attributable cases five cancer types accounting residual 80000 cancers cervical cancer third common female malignancy shows strong association level development rates least fourfold higher countries defined within low ranking human development index hdi compared high category similar disparities evident 5year survivalless 20 low hdi countries 65 high countries fivefold greater differences incidence world regions countries reliable temporal data available incidence rates appear consistently declining approximately 2 per annum however lack information low hdi countries screening less likely successfully implemented estimates projected incidence cervical cancer 2030 based solely demographic factors indicate 2 increase global burden cervical cancer ie balance current rate decline due relative small numbers involved difficult discern temporal trends cancers associated hpv infection genital warts represent sexually transmitted benign condition caused hpv infection especially hpv6 hpv11 reliable surveillance figures difficult obtain data developed countries indicate annual incidence 01 02 peak occurring teenage young adult ages article forms part special supplement entitled comprehensive control hpv infections related diseases vaccine volume 30 supplement 5 2012