Laura A. McGuinn|Cavin Ward?Caviness|Lucas Neas|Alexandra Schneider|David Díaz-Sánchez|Wayne E. Cascio|William E. Kraus|Elizabeth R. Hauser|Elaine Dowdy|Carol Haynes|Alexandra Chudnovsky|Petros Koutrakis|Robert B. Devlin
Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease
University of North Carolina at Chapel Hill|Helmholtz Zentrum München|Environmental Protection Agency|Helmholtz Zentrum München|Environmental Protection Agency|Environmental Protection Agency|Duke University|Duke University|Duke University|Duke University|Tel Aviv University|Environmental Protection Agency
epidemiological studies identified associations longterm pm25 exposure cardiovascular events though relied concentrations centralsite air quality monitorswe utilized cohort 5679 patients undergone cardiac catheterization duke university 20022009 resided north carolina used estimates daily pm25 concentrations north carolina study period based satellite derived aerosol optical depth aod measurements pm25 concentrations ground monitors spatially resolved 1010km resolution matched patients residential address averaged year prior catheterization coronary artery disease cad index used measure severity cad scores 23 represent hemodynamically significant coronary artery lesion least one major coronary vessel logistic regression modeled odds cad mi 1gm3 increase annual average pm25 adjusting sex race smoking status socioeconomic statusin adjusted models 1gm3 increase annual average pm25 associated 111 relative increase odds significant cad 95 ci 40186 142 increase odds myocardial infarction mi within year prior 95 ci 37258satellitebased estimates longterm pm25 exposure associated coronary artery disease cad incidence myocardial infarction mi cohort cardiac catheterization patients