Gregory Reardon|Kotak|GF Schwartz
Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: a systematic review
The Ohio State University|Pfizer (United States)|Johns Hopkins University|Greater Baltimore Medical Center
purpose study summarizes findings objective assessments compliance adherence persistence ocular hypotensive agents patients glaucoma ocular hypertensiondesign systematic literature reviewmethods pubmed reference list search conducted across publication years 19702010 using terms variants compliance equivalent term adherence persistence patients conditions therapiessummaries selected studies stratified measurement method electronic monitor prescription fills review medical chart reviewmeasures central tendency across studies calculated commonlyreported compliance persistence measuresresults fiftyeight articles met inclusionexclusion criteria measurement complianceelectronic monitoring seven studies reported 14 articles measurement compliance persistenceprescription records 36 studies 38 articles measurement persistencemedical chart review six studies six articlesfrom electronic monitoring therapyexperienced patients took medication consistently 20 met criteria poor compliancefrom prescription records 56 range 3792 days first therapy year could dosed medication supply dispensed periodat 12 months therapy start 31 range 1068 new therapy users discontinued 40 range 1467 discontinued changed initial therapyfrom medical chart review 67 range 6278 patients remained persistent 12 months starting therapyconclusions evidence provided review suggests poor compliance persistence remains common problem many glaucoma patients especially problematic patients new therapythe direction empirical research shift toward greater emphasis understanding root causes identification testing solutions problem