Nitin Agarwal, Andrew K Chan, Erica F Bisson, Steven D Glassman, Kevin T Foley, Christopher I Shaffrey, Oren N Gottfried, Luis M Tumialán, Eric A Potts, Mark E Shaffrey, Domagoj Coric, John J Knightly, Sufyan Ibrahim, Rida Mitha, Giorgos Michalopoulos, Paul Park, Michael Y Wang, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Jian Guan, Regis W Haid, Dean Chou, Mohamad Bydon, Praveen V Mummaneni
Impact of educational background on preoperative disease severity and postoperative outcomes among patients with lumbar spondylolisthesis: a Quality Outcomes Database study
Journal of neurosurgery. Spine
formative period adolescence plays crucial role development skills abilities adulthood adolescents affected mental health conditions risk suicide social academic impairments geneenvironment complementary contributions molecular mechanisms involved psychiatric disorders emphasized need analyze epigenetic marks dna methylation dnam noncoding rnas however large diverse bioinformatic statistical methods referring confounders statistical models application multipletesting adjustment methods questions regarding correlation dnam across tissues sexdependent differences results raised challenges regarding interpretation results based example generalized anxiety disorder gad depressive disorder mdd shed light current knowledge usage methodological tools analyzing epigenetics statistical robustness essential prerequisite better understanding interpretation epigenetic modifications helps find novel targets personalized therapeutics psychiatric diseases