Michael A Gottfried, Arya Ansari
Detailing New Dangers: Linking Kindergarten Chronic Absenteeism to Long-Term Declines in Executive Functioning
The Elementary school journal
world health organization recommends tenofovir disoproxil fumarate tdfbased oral preexposure prophylaxis prep dapivirine vaginal ring longacting intramuscular injectable cabotegravir cabla hiv prevention populations substantial risk hiv infection pregnancy period elevated risk maternal hiv infection transmission infant systematic review metaanalysis assessed risk adverse perinatal outcomes among hivnegative pregnant women exposure prep modality conducted systematic review searching medline embase cinahl global health cochrane library ictr isrctn pactr clinicaltrialsgov studies published 1 january 2000 29 august 2023 included studies reporting association antenatal exposure prep modality 13 perinatal outcomes preterm birth ptb ptb spontaneous ptb spontaneous ptb low birthweight lbw lbw term lbw preterm lbw small gestational age sga sga miscarriage stillbirth neonatal death nnd quality assessments included studies performed fixedeffect metaanalyses conducted calculate odds ratios ors 95 confidence intervals 95 cis protocol registered prospero crd42022339825 18598 citations identified 13 studies eight randomised controlled trials rcts five cohort studies assessing 8712 pregnant women africa included oral prep compared prep associated ptb metaanalyses six rcts 073 95 ci 043126 i2 00 five unadjusted cohort studies 084 95 ci 069103 i2 00 associated reduced risk ptb three adjusted cohort studies aor 067 95 ci 052088 i2 00 association oral prep lbw vlbw sga nnd compared prep association ptb oral tdfemtricitabine ftc prep oral tdf prep tenofovir vaginal gel compared association dapivirine vaginal ring ptb nnd compared placebo oral tdfftc prep found data cabla found evidence adverse perinatal outcomes associated prep exposure pregnancy findings support recommendation provide oral prep women reproductive age pregnant women data needed assess safety prep modalities pregnancy none