Tiffany R Bellomo, Guillaume Goudot, Srihari K Lella, Brandon Gaston, Natalie Sumetsky, Shiv Patel, Nikolaos Zacharias, Anahita Dua
Percent Thrombus Predicts Popliteal Artery Aneurysm Related Limb Threatening Events
Annals of surgery
exosomes play crucial role intercellular communication clear cell renal cell carcinoma ccrcc long noncoding rnas lncrnas implicated tumorigenesis progression purpose study construction exosomesrelated lncrna score cerna network predict response immunotherapy potential targeted drug ccrcc data ccrcc patients obtained tcga database pearson correlation analysis used identify eexosomesrelated lncrnas erlrs top10 exosomesrelated genes screened entire cohort randomly divided training cohort validation cohort equal scale lasso regression multivariate cox regression used construct erlrsbased score differences clinicopathological characteristics immune microenvironment immune checkpoints drug susceptibility high lowrisk groups also investigated finally relevant cerna network constructed machine learning analyze potential targets immunotherapy drug use ccrcc patients score consisting 4erlrs identified patients higher erlrsbased score tended worse prognosis lower erlrsbased score roc curves multivariate cox regression analysis demonstrated score could considered risk factor prognosis training validation cohorts moreover patients high scores predisposed experience poor overall survival larger prevalence advanced stage iiiiv greater tumor mutational burden higher infiltration immunosuppressive cells greater likelihood responding favorably immunotherapy importance emx2os determined mechanical learning cerna network constructed emx2os may potential therapeutic target possibly exerting function emx2oshsamir315ptln2 axis based machine learning novel erlrsbased score constructed predicting survival ccrcc patients erlrsbased score promising potential independent prognostic factor closely correlated immune microenvironment clinicopathological characteristics meanwhile screened key lncrnaemx2os identified emx2oshsamir315ptln2 axis may provide new clues targeted therapy ccrcc