Allison R. Kaup|Amy L. Byers|Cherie Falvey|Eleanor M. Simonsick|Suzanne Satterfield|Hilsa N. Ayonayon|Stephen F. Smagula|Susan M. Rubin|Kristine Yaffe
Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia
San Francisco VA Medical Center|University of California, San Francisco|University of California, San Francisco|San Francisco VA Medical Center|University of California, San Francisco|National Institute on Aging|University of Tennessee Health Science Center|University of California, San Francisco|University of Pittsburgh|University of California, San Francisco|San Francisco VA Medical Center|University of California, San Francisco
depression identified risk factor dementia however studies measured depressive symptoms one time point older adults may show different patterns depressive symptoms timeto investigate association trajectories depressive symptoms risk dementia older adultsthis prospective cohort investigation black white communitydwelling older adults health aging body composition study participants enrolled may 1997 june 1998 followed 20012002 dates analysis september 2014 december 2015 setting community research centers memphis tennessee pittsburgh pennsylvania trajectories depressive symptoms assessed baseline year 5 symptoms measured center epidemiologic studies depression scale short form trajectories calculated using latent class growth curve analysisincident dementia year 11 determined dementia medication use hospital records significant cognitive decline 15 sd racespecific decline modified minimental state examination examined association depressive symptom trajectories dementia incidence using cox proportional hazards regression models adjusted demographics health factors differed groups cognition depressive symptom assessment period baseline year 5the analytic cohort included 2488 black white older adults repeated depressive symptom assessments baseline year 5 free dementia throughout period mean sd age baseline 740 28 years 531 n 1322 female following 3 depressive symptom trajectories identified consistently minimal symptoms 620 n 1542 participants moderate increasing symptoms 322 n 801 participants high increasing symptoms 58 n 145 participants compared consistently minimal trajectory high increasing depressive symptom trajectory associated significantly increased risk dementia fully adjusted hazard ratio 194 95 ci 130290 moderate increasing trajectory associated risk dementia full adjustment sensitivity analyses indicated high increasing trajectory associated dementia incidence depressive symptoms individual time points notolder adults longitudinal pattern high increasing depressive symptoms high risk dementia individuals trajectory depressive symptoms may inform dementia risk accurately onetime assessment depressive symptoms