Alex M Silver, Mackenzie Swirbul, Catherine S Tamis-LeMonda, Natasha Cabrera, Melissa E Libertus
Investigating associations between parent engagement and toddlers' mathematics performance
The British journal of developmental psychology
order ensure safer use nonvitamin k antagonist oral anticoagulants noacs continuously detecting unexpected adverse drug reactions adrs market approval necessary performed disproportionality analysis evaluate association adrs noacs including apixaban dabigatran rivaroxaban using data korea institute drug safety risk managementkorea adverse event reporting system database kidskd 2012 2016 significant signal bleeding considering quantity signal strength seriousness causality order evaluate noac reports bleeding selected 62 whoart diagnostic codes associated bleeding among 26 codes referred major bleeding 18 codes referred gastrointestinal bleeding 8 referred intracranial bleeding evaluated significance signals using reporting odds ratios rors adjusted age sex treatments apixaban dabigatran rivaroxaban associated 1989 1668 2960 adverse events respectively type bleeding apixaban dabigatran rivaroxaban warfarin reported 174 88 209 125 523 178 620 95 events respectively bleeding adjusted rors apixaban dabigatran rivaroxaban 099 95 confidence interval ci 083117 147 95 ci 125175 248 95 ci 216284 respectively respect major bleeding adjusted rors apixaban dabigatran rivaroxaban 108 95 ci 082141 146 95 ci 110190 182 95 ci 143232 respectively rivaroxaban might stronger association bleeding apixaban dabigatran