Silvia Potì, Laura Palareti, Frederica Rmy Cassis, Sonia Brondi
Health care professionals dealing with hemophilia: insights from the international qualitative study of the HERO initiative
Journal of multidisciplinary healthcare
radiological diagnosis based subjective judgment radiologists reasoning behind process difficult document share major obstacle adopting evidencebased medicine radiology report attempt use comprehensive brain parcellation tool systematically capture image features use record search evaluate anatomical phenotypes anatomical images t1weighted mri converted standardized index using highdimensional image transformation method followed atlasbased parcellation entire brain investigated indexed anatomical data captured anatomical features healthy controls population primary progressive aphasia ppa ppa chosen patients apparent atrophy different degrees locations thus automated quantitative results compared trained clinicians qualitative evaluations explored tested power individual classifications performing search images similar anatomical features database using partial least squaresdiscriminant analysis plsda principal component analysis pca agreement automated zscore averaged visual scores atrophy r 08 virtually interevaluator agreement pca plot distribution correlated anatomical phenotypes plsda resulted model accuracy 88 distinguishing ppa variants quantitative indices captured main anatomical features indexing image data potential effective comprehensive easily translatable tool clinical practice providing new opportunities mine clinical databases medical decision support