Jamie Sin-Ying Ho|D Fernando|Mark Y. Chan|Ching?Hui Sia
Obesity in COVID-19: A Systematic Review and Meta-analysis
University of Cambridge|University of Cambridge|National University Heart Centre Singapore|National University Heart Centre Singapore|University of Cambridge
abstract objective obesity shown associated adverse outcomes viral infections influenza previous studies coronavirus disease 2019 covid19 mixed results aim systematic review investigate relationship covid19 obesity methods performed systematic review metaanalysis literature search medline embase scopus web science central opengrey preprint servers medrxiv biorxiv performed restriction language date publication primary outcomes study intensive care unit icu admission critical disease severe disease mortality secondary outcome positive covid19 test metaanalysis performed using openmetaanalyst software heterogeneity tested using cochrans q test i2 statistic study protocol registered prospero crd42020184953 results total 1493 articles identified 61 studies 270241 patients included pooled prevalence obesity 276 95 confidence interval ci 220332 hospitalised patients obesity significantly associated increased icu admission critical illness odds ratio 125 95 ci 099158 p0062 i2310 significantly associated severe disease 313 95 ci 141692 p0005 i2826 mortality 136 95 ci 109169 p0006 i2885 positive covid19 test 150 95 ci 125181 plt0001 conclusion obesity increased risk severe disease mortality infection covid19 higher body mass index associated icu admission critical disease patients obese may susceptible severe acute respiratory syndrome coronavirus 2 sarscov2 infection infected patients monitored closely adverse outcomes keywords body mass index coronavirus intensive care mortality prognosis