Andreas Machens|Kerstin Lorenz|Carsten Sekulla|Wolfgang Höppner|Karin Frank?Raue|Friedhelm Raue|Henning Dralle
Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium
Martin Luther University Halle-Wittenberg|Martin Luther University Halle-Wittenberg|Martin Luther University Halle-Wittenberg|Bioglobe (Germany)|Martin Luther University Halle-Wittenberg
objective twenty years ago groundbreaking discovery rearranged transfection ret mutations underlie multiple endocrine neoplasia 2 men2 familial medullary thyroid cancer fmtc ushered era personalized medicine men2associated signs taking time manifest subtle study sought clarify extent conventional estimates 1200 000500 000 underestimate incidence ret mutations population design included retrospective investigation 333 ret carriers born 1951 2000 operated largest german surgical referral center 286 carriers elsewhere 47 carriers methods estimate incidence ret mutations number ret carriers born germany five decades 19511960 19611970 19711980 19811990 19912000 divided corresponding number german live births results owing improved diagnosis capture fmtc men2 patients minimum incidence estimates increased time overall 50 19511960 99 19912000 per million live births year p 0008 american thyroid associationata class 17 37 ata class c p 0008 18 27 ata class p 0017 15 22 ata class b p 020 0 14 ata class mutations per million live births year p 0008 based 19912000 incidence estimates prevalence germany 180 000 inhabitants conclusions molecular minimum incidence estimate 1100 000 two fivefold greater conventional estimates 1200 000500 000