Xuejian Cui, Xiaoyang Chen, Zhen Li, Zijing Gao, Shengquan Chen, Rui Jiang
Discrete latent embedding of single-cell chromatin accessibility sequencing data for uncovering cell heterogeneity
Nature computational science
review aims discussing application quality design qbd approach development dry powders inhalers dpis starts thorough presentation qualitys concept evolution within pharmaceutical sector slowly adopted set quality guidelines major scientific regulatory requirement dpis represent type delivery system systems thinking approach integrating device formulation patient represent major challenge met within context review points critical gaps optimization exercise proposes series remedies overcoming obstacles systems parts viewed alone whole statistical thinking corresponding tools means successfully carrying purpose qbd another guideline simply comply ultimate scope pharmaceutical development effort fully understand consistently meet patients needs entire lifecycle product qbd focusing delivering quality value patients without compromises products safety effectiveness profile