Michael R Le Grande, Marielle Salvacion, Lubab Shwaita, Barbara M Murphy, Alun C Jackson, Marlies E Alvarenga
Does coping style mediate the relationship between knowledge and psychosocial outcomes in women with atrial fibrillation?
Frontiers in psychiatry
little known neonatal brain plasticity impact birth mode neurointegrity reflection neuroaxonal damage neuronal structural protein neurofilament light chain nfl emerged highly specific biomarker purpose test hypothesis vaginal delivery associated increased nfl neonates nfl concentrations measured using singlemolecule array immunoassay umbilical cord serum healthy term neonates enrolled prospective kunokids health study nfl values investigated independent influencing factors using linear logistic models followed post hoc propensity scorematching 665 neonates n 470 707 delivered vaginally n 195 293 cesarean section median serum nfl significantly higher vaginal delivery 144 pgml 116185 compared primary 75 pgml 6189 secondary cesarean delivery 93 pgml 75120 multivariable logistic regression models showed delivery mode gestational age independently associated nfl propensity scorematching analysis confirmed assisted vaginal delivery generated higher nfl compared vaginal nonassisted lowest levels associated cesarean section data confirm significant impact birth mode neonatal nfl levels persistence differences potential longterm impact yet investigated