Emma Vaugoyeau, Lison Rambliere, Manon David, Hanaa Lemguarni, Sylvie Le Gac, Armelle Pasquet-Cadre, Samy Rasli, Jade Ghosn, Willy Rozenbaum, Elisabeth Bouvet, Maëlle Prioux
Proof of concept of a sexual health outreach program led by community health workers in homeless hostels in the greater Paris region
Frontiers in public health
computational mathematical models must silico analysis design gene regulatory networks grnas offer theoretical context deeply address biological regulation proposed framework models network dynamics expressed class nonlinear temporal multiscale ordinary differential equations ode find models disclose network structures underlying observed desired network behavior parameter values enable candidate models reproduce behavior follow reasoning cycle alternates procedures model selection parameter refinement plausible network models first selected via qualitative simulation next parameters given quantitative values ode model solution reproduces specified behavior paper gives algorithms tackle parameter refinement problem formulated optimization problem search within parameter space symbolically expressed largest hypersphere whose points correspond parameter values ode solution gives instance given qualitative trajectory approach overcomes limitation previously proposed stochastic approach namely computational load reduced scalability applicability effectiveness demonstrated two benchmark synthetic networks different complexity