Anne-Sophie Vaillant-Corroy, Félix Girard, François Virard, Pascale Corne, Caroline Gerber Denizart, Claudine Wulfman, Sibylle Vital, Marjolaine Gosset, Adrien Naveau, Yves Delbos, Jean-Noël Vergnes, Béatrice Thivichon-Prince, Juliette Antoine, Gisele Mainville, Moussa Nader, Raphael Richert, Bernard Charlin, Maxime Ducret
Concordance of judgement: A tool to foster the development of professionalism in dentistry
European journal of dental education : official journal of the Association for Dental Education in Europe
hematological disorders pose diagnostic challenge due overlapping clinical features demonstrated difficulty differentiating aplastic anemia aa primary myelofibrosis pm myeloproliferative disorders characterized aberrant proliferation bone marrow stem cells present complexities diagnosis often requiring comprehensive evaluation distinguish disorders similar manifestations distinctions myelofibrosis aa lie clinical presentations also genetic molecular markers necessitating nuanced diagnostic approach present case 37yearold male initially diagnosed myelofibrosis based history pancytopenia warm submandibular submental swelling negative bcrabl jak2 mutations examination revealed empty fragmented cells hypoplastic bone marrow suppressed erythropoiesis myelopoiesis subsequent core biopsy showed increased megakaryocytes prompting revised diagnosis aa case underscores importance meticulous diagnostic journey incorporating physical examination genetic testing advanced imaging unravel complexities hematological disorders intricacies case prompt reevaluation diagnostic paradigms highlighting limitations relying solely specific mutations diagnosis absence bcrabl jak2 mutations aa raises questions genetic landscape necessitating exploration immunological considerations given immunemediated nature aa provide foundation future research immune dysregulation potential therapeutic interventions clinical management challenges posed aa underscore need personalized treatment strategies guided deeper understanding underlying pathophysiology advanced imaging techniques conjunction traditional diagnostic methods emerge crucial tools enhancing diagnostic accuracy hematological disorders case serves paradigm ongoing medical education multidisciplinary collaboration innovative approaches evolving landscape hematology emphasizing imperative continuous refinement diagnostic strategies patient care