Marcus J. Rijken|Aris T. Papageorghiou|Supan Thiptharakun|Suporn Kiricharoen|Saw Lu Mu Dwell|Jacher Wiladphaingern|Mupawjay Pimanpanarak|Stephen Kennedy|François Nosten|Rose McGready
Ultrasound Evidence of Early Fetal Growth Restriction after Maternal Malaria Infection
Shoklo Malaria Research Unit|University of Oxford|Shoklo Malaria Research Unit|Shoklo Malaria Research Unit|Shoklo Malaria Research Unit|Shoklo Malaria Research Unit|Shoklo Malaria Research Unit|University of Oxford|Mahidol University|Shoklo Malaria Research Unit|University of Oxford|Mahidol Oxford Tropical Medicine Research Unit|University of Oxford|Mahidol Oxford Tropical Medicine Research Unit|Mahidol University|Shoklo Malaria Research Unit
intermittent preventive treatment ipt main strategy prevent malaria reduce anaemia low birthweight focuses second half pregnancy however intrauterine growth restriction may occur earlier pregnancy aim study measure effects malaria first half pregnancy comparing fetal biparietal diameter bpd infected uninfected women whose pregnancies accurately dated crown rump length crl 14 weeks gestationin 3779 women living thaimyanmar border delivered normal singleton live born baby 200110 gestational age estimated crl measurement 14 weeks observed expected bpd zscores 24 weeks pregnancies n 336 n 3443 complicated malaria two scans compared mean standard deviation fetal bpd zscores women plasmodium p falciparum andor pvivax malaria infections significantly lower noninfected pregnancies 057 113 versus 010 117 p0001 even single asymptomatic malaria episode resulted significantly lower zscore fetal female sex p0001 low body mass index p 001 also independently associated smaller bpd multivariate analysisdespite early treatment positive women one asymptomatic pfalciparum pvivax malaria infections first half pregnancy result smaller expected midtrimester fetal head diameter strategies prevent malaria pregnancy include early pregnancy