Siyu Chen, Diana Cárdenas, Haochen Zhou, Katherine J Reynolds
Positive school climate and strong school identification as protective factors of adolescent mental health and learning engagement: A longitudinal investigation before and during COVID-19
Social science & medicine (1982)
background several environmental genetic factors contributed development colorectal cancer crc aimed investigate independent combined effects selected risk factors arg399gln xrcc1 polymorphism crc methods total 180 patients crc 160 healthy individuals matched sex age place residence northeast iran participated casecontrol study collecting blood samples filling questionnaires written consent form obtained participants genotypes determined rflppcr comparison genotype allele frequencies performed using p value based results chisquare test odds ratios 95 confidence intervals ci calculated employing logistic regression model statistical calculations performed using spss 2 sided p values less 005 considered statistically significant results level literacy physical activity consumption vegetables fruits tea intake patients significantly lower healthy individuals gastrointestinal disorders family history cancer bmi fast food consumption significantly higher cases controls significant difference observed 2 groups regarding smoking opioid addiction alcohol consumption diet fish consumption liquid intake using kitchen hood diabetes cardiovascular disease arggln glngln arggln genotypes involved increased crc risk crude 1781 95 ci 11562744 1690 95 ci 07873630 also glngln genotype frequent crc group control group however none risk factors interacted polymorphism thus effect crc conclusion risk factors reducing consumption vegetables fruits reducing physical activity well polymorphism xrcc1 arg399gln alone increase risk crc interact