Márcia Scazufca|Pedro de Lemos Menezes|Ricardo Araya|Vanessa D. Di Rienzo|Oslei Paes de Almeida|David Gunnell|Debbie A Lawlor
Risk factors across the life course and dementia in a Brazilian population: results from the Sao Paulo Ageing &amp; Health Study (SPAH)
University of Bristol|Universidade de São Paulo|Hospital Universitário da Universidade de São Paulo|University of Bristol|Hospital Universitário da Universidade de São Paulo|Universidade de São Paulo|University of Bristol|Universidade de São Paulo|Hospital Universitário da Universidade de São Paulo|Royal Perth Hospital|University of Western Australia|University of Bristol|University of Bristol
several mechanisms suggested explain association adversities across life dementia study aimed investigate association indicators socioeconomic disadvantages throughout lifecourse dementia among older adults sao paulo brazil explore possible causal pathwayswe used baseline data spah study involved participants aged 65 years older n 2005 outcome interest prevalent dementia exposures included analyses socioeconomic position sep indicators childhood place birth literacy adulthood occupation income anthropometric measurements markers intrauterine childhood environment head circumference leg length smoking diabetes hypertension logistic regression models used test hypothesized pathways assess whether association cumulative adversities across life course prevalent dementiaindicators socioeconomic disadvantage early life associated increased prevalence dementia association partially mediated adulthood sep head circumference leg length also clearly associated dementia evidence association mediated early life socioeconomic disadvantage association cumulative unfavourable conditions across life course dementiaearly life disadvantages seem operate biological mechanisms associated passive brain reserve opportunities life representing active cognitive reserve prevention dementia start early life continue life span seen many chronic diseases