Ashley N Edelen, Sarah Cashman, Ben Young, Wesley W Ingwersen
Life Cycle Data Interoperability Improvements through Implementation of the Federal LCA Commons Elementary Flow List
Applied sciences (Basel, Switzerland)
postpartum blues ppb frequent syndrome sad mood crying spells anxiety restlessness reduced appetite irritability typically peaking day 5 postpartum severe greatly increases risk later postpartum depression trial compared dietary supplement placebo ppb severity supplement designed counter downstream effects elevated monoamine oxidase level implicated causing ppb participants recruited advertisement toronto region completed procedures camh canada andor participants homes oral supplement identical appearing relatively inert placebo administered randomised doubleblind fashion supplement blueberry juice extract given four times nighttime day 3 morning day 5 postpartum tryptophan 2 g nighttime day 4 postpartum tyrosine 10 g morning day 5 postpartum day 5 depressed mood induction procedure mip postpartum blues assessed data presented nct03296956 closed clinicaltrialsgov january 2019 december 2022 participants took supplement n 51 placebo n 52 significant effect primary outcome mip visual analogue scale depressed mood mean difference 039 mm 95 ci 642 565 mm stein maternity blues scores exploratory ppb measure lower active group effect size 062 median interquartile range iqr active 200 iqr 1 4 placebo 400 iqr 15 6 regression general linear model supplement effect coefficient 150 95 ci 260 040 p 0008 effect cesd crying category supplement p 003000000023 twentysix 40 different adverse events occurred within 25 42 supplement placebo cases respectively chisquare p 006 primary outcome negative effect depressed mood induction however supplement moderately reduced ppb camhexeltis