Aireen Wingert|Jennifer Pillay|Michelle Gates|Samantha Guitard|Sholeh Rahman|Andrew Beck|Ben Vandermeer|Lisa Hartling
Risk factors for severity of COVID-19: a rapid review to inform vaccine prioritisation in Canada
University of Alberta|University of Alberta|University of Alberta|University of Alberta|University of Alberta|University of Alberta|University of Alberta|University of Alberta
objectives rapid review determine magnitude association potential risk factors severity covid19 inform vaccine prioritisation canada setting ovid medliner epistemonikos covid19 love platform mcmaster covid19 evidence alerts websites searched 15 june 2020 eligible studies conducted highincome countries used multivariate analyses participants piloting screening data extraction quality appraisal performed single experienced reviewer 3740 unique records identified 34 included reported median 596 range 44418 794 participants aged 4284 years 1934 56 good quality outcomes hospitalisation intensive care unit admission length stay hospital intensive care unit mechanical ventilation severe disease mortality results authors synthesised findings narratively appraised certainty evidence risk factoroutcome association low moderate certainty evidence large 2fold magnitude association hospitalisation people covid19 obesity class iii heart failure diabetes chronic kidney disease dementia age gt45 years male gender black raceethnicity vs nonhispanic white homelessness low income age gt60 gt70 years may associated large increases mechanical ventilation severe disease respectively mortality large magnitude association may exist liver disease bangladeshi ethnicity vs british white age gt45 years age gt80 years vs 6569 years male gender among 2064 years older associations hospitalisation mortality may large 5fold aged 60 years conclusions increasing age especially gt60 years may important risk factor severe outcomes highquality primary research accounting multiple confounders needed better understand magnitude associations severity covid19 several factors prospero registration number crd42020198001