Michael L Barnett, Bruce Lee Pihlstrom
A practitioner's guide to developing critical appraisal skills: interventional studies
Journal of the American Dental Association (1939)
prevalence neurological involvement patients deletion variant hnf1b gene remains discussed aim study investigate neuropsychological outcomes large cohort children carrying either hnf1b wholegene deletion diseaseassociated variant revealed presence kidney anomalies neuropsychological developmentbased school levelof 223 children included prospective cohort studied data 180 children available analysis patients mean age 96 years 399 girls among patients 119 carried hnf1b deletion 61 diseaseassociated variant schoolaged population 127 36 patients carrying hnf1b deletion diseaseassociated variant special educational needs respectively therefore presence hnf1b deletion increases risk present neuropsychiatric involvement compared general population hand almost 90 patients carrying hnf1b diseaseassociated variant deletion normal schooling general educational environment even findings predict risk neuropsychiatric disease adulthood patients diagnosed secondary kidney anomalies show neurological outcome severe enough impede standard schooling elementary school results taken account prenatal counseling