Dimitrios Stefanidis, Laura Torbeck, Amy H Kaji
Practical Guide to Common Flaws With Surgical Education Research
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bronchopulmonary dysplasia bpd multifactorial etiology vitamin e vitamin play important role lung development potentially beneficial prevention bpd study aimed compare risk bpd occurrence preterm neonates supplemented vitamin e versus get supplementation literature search conducted systematic review searching pubmed scopus web science databases december 2022 randomized controlled trials involved administering vitamin e preterm neonates examining occurrence bpd excluded nonenglish articles articles nonrelevant insufficient data used critical appraisal skills programme casp checklist assess quality included studies used eggers test evaluate risk bias among included studies heterogeneity also assessed qtest i2 applied random effect model analysis pvalue less 005 considered significant statistical analysis current study performed using stata 14 relative risk rr calculated effect size 95 confidence interval ci three eligible studies seeking role vitamin prevention bpd analysed metaanalysis revealed receiving vitamin supplementation significantly reduce risk bpd preterm infants rr 0357 95 ci 01890675 i2 00 p 0002 similarly assessing role vitamin e prevention bpd three eligible studies analysed vitamin e supplementation found play significant role reduction bpd rr 0659 95ci 02431786 i2 387 p 0412 vitamin supplementation could beneficial preventing bpd preterm infants however evidence enough regarding vitamin es role reducing incidence bpd preterm infants