Abdullah Ashraf Hamad, Jaber H Jaradat, Hamza K Alsalhi, Ibraheem M Alkhawaldeh
Medical research production in native languages: A descriptive analysis of PubMed database
Qatar medical journal
main stumbling block clinical management search cure alzheimer disease ad cause disorder remained uncertain nowevidence sporadic nongenetic ad primarily vascular rather neurodegenerative disorder reviewed conclusion based following evidence 1 epidemiological studies showing practically risk factors ad reported thus far vascular component reduces cerebral perfusion 2 risk factor association ad vascular dementia vad 3 improvement cerebral perfusion obtained pharmacotherapy used reduce symptoms progression ad 4 detection regional cerebral hypoperfusion use neuroimaging techniques preclinically identify ad candidates 5 presence regional brain microvascular abnormalities cognitive neurodegenerative changes 6 common overlap clinical ad vad cognitive symptoms 7 similarity cerebrovascular lesions present ad vad patients 8 presence cerebral hypoperfusion preceding hypometabolism cognitive decline neurodegeneration ad 9 confirmation heterogeneous multifactorial nature ad likely resulting diverse presence vascular risk factors indicators vascular diseasesince value scientific evidence generally revolves around probability chance concluded data presented pose powerful argument support proposal ad classified vascular disorder according elementary statistics probability chance findings due indirect pathological effect coincidental circumstances related disease process ad seems highly unlikely collective data presented review strongly support concept sporadic ad vascular disorder recommended current clinical management patients treatment targets research designs disease prevention efforts need critically reassessed placed perspective light important findings