Haroldo da Silva Ferreira, Myrtis Katille de Assunção Bezerra, Monica Lopes de Assunção, Risia Cristina Egito de Menezes
Prevalence of and factors associated with anemia in school children from Maceió, northeastern Brazil
BMC public health
sex crucial variable take account medical research review attempted present importance stages research even drugs postmarketing surveillance preclinical research studies take sex account many diseases known present sexual dimorphism however shift thinking occurred since january 2016 implementation us institutes health recommendations take sex account research nevertheless preclinical studies lack sexbased statistical analyses persists moreover humans women often underrepresented clinical trials despite wellidentified sexual dimorphism addition pathologies subject social representations diseases considered male female also lead delay diagnosis management sexes finally many drug classes may subject sex differences efficacy safety example women present adverse events men mainly different pharmacokinetic parameters accounting sex variable preclinical phase essential improve transposition observed results move towards personalized medicine