Helena Teede|Marie Misso|Michael Costello|Anuja Dokras|Joop S.E. Laven|Lisa Moran|Terhi Piltonen|Robert J. Norman|Marianne Andersen|Ricardo Azziz|Adam Balen|Estifanos Baye|Jacqueline Boyle|Leah Brennan|Frank J. Broekmans|Preeti Dabadghao|Luigi Devoto|Didier Dewailly|Linda Downes|Bart C.J.M. Fauser|Stephen Franks|Rhonda Garad|Melanie Gibson?Helm|Cheryce L. Harrison|Roger Hart|Rachel Hawkes|Angelica Lindén Hirschberg|Kathleen Hoeger|Femke Hohmann|Samantha Hutchison|Anju E. Joham|Louise Johnson|Cailin Jordan|Jayashri Kulkarni|Richard S. Legro|Rong Li|Marla E. Lujan|Jaideep Malhotra|Darren Mansfield|Kate Marsh|Veryan McAllister|Edgar Mocanu|Ben Willem J. Mol|Ernest Hung Yu Ng|Sharon E. Oberfield|Sasha Ottey|Alexia Peña|Jie Qiao|Leanne M. Redman|Raymond J. Rodgers|Luk Rombauts|Daniela Romualdi|Duru Shah|Jane Speight|Poli Mara Spritzer|Elisabet Stener?Victorin|Nigel K. Stepto|Juha S. Tapanainen|Eliza C. Tassone|Shakila Thangaratinam|Mala Thondan|Chii?Ruey Tzeng|Z.M. van der Spuy|Eszter Vanky|Maria G Vogiatzi|Ching Shan Wan|Chandrika Wijeyaratne|Selma F. Witchel|Jane Woolcock|Bülent Okan Y?ld?z
Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
National Health and Medical Research Council|University of Adelaide|Monash Health|Monash University|National Health and Medical Research Council|University of Adelaide|Monash Health|Monash University|UNSW Sydney|University of Pennsylvania|Erasmus University Rotterdam|National Health and Medical Research Council|University of Adelaide|Monash Health|Monash University|Oulu University Hospital|National Health and Medical Research Council|University of Adelaide|Monash University|National Health and Medical Research Council|Monash University|University of Adelaide|Monash Health
recommended assessment management women polycystic ovary syndrome pcos based best available evidence clinical expertise consumer preferenceinternational evidencebased guidelines including 166 recommendations practice points addressed prioritized questions promote consistent evidencebased care improve experience health outcomes women pcosprevious guidelines either lacked rigorous evidencebased processes engage consumer international multidisciplinary perspectives outdated diagnosis pcos remains controversial assessment management inconsistent needs women pcos adequately met evidence practice gaps persistinternational evidencebased guideline development engaged professional societies consumer organizations multidisciplinary experts women pcos directly involved stages appraisal guidelines research evaluation agree iicompliant processes followed extensive evidence synthesis grading recommendations assessment development evaluation grade framework applied across evidence quality feasibility acceptability cost implementation ultimately recommendation strengthgovernance included six continent international advisory project board five guideline development groups consumer translation committees extensive health professional consumer engagement informed guideline scope priorities engaged international societynominated panels included pediatrics endocrinology gynecology primary care reproductive endocrinology obstetrics psychiatry psychology dietetics exercise physiology public health experts alongside consumers project management evidence synthesis translation experts thirtyseven societies organizations covering 71 countries engaged process twenty facetoface meetings 15 months addressed 60 prioritized clinical questions involving 40 systematic 20 narrative reviews evidencebased recommendations developed approved via consensus voting within five guideline panels modified based international feedback peer review final recommendations approved across panelsthe evidence assessment management pcos generally low moderate quality guideline provides 31 evidence based recommendations 59 clinical consensus recommendations 76 clinical practice points related assessment management pcos key changes guideline include considerable refinement individual diagnostic criteria focus improving accuracy diagnosis ii reducing unnecessary testing iii increasing focus education lifestyle modification emotional wellbeing quality life iv emphasizing evidence based medical therapy cheaper safer fertility managementoverall evidence generally low moderate quality requiring significantly greater research neglected yet common condition especially around refining specific diagnostic features pcos regional health system variation acknowledged process guideline translation resource adaptation providedthe international guideline assessment management pcos provides clinicians clear advice best practice based best available evidence expert multidisciplinary input consumer preferences research recommendations generated comprehensive multifaceted dissemination translation program supports guideline integrated evaluation programthe guideline primarily funded australian national health medical research council australia nhmrc supported partnership eshre american society reproductive medicine guideline development group members receive payment travel expenses covered sponsoring organizations disclosures conflicts interest declared outset updated throughout guideline process aligned nhmrc guideline processes full details conflicts declared across guideline development groups available httpswwwmonashedumedicinesphpmmchripcosguideline register disclosures interest named authors dr costello declared shares virtus health past sponsorship merck serono conference presentations prof laven declared grants ferring euroscreen personal fees ferring euroscreen danone titus healthcare prof norman declared minor shareholder interest ivf unit remaining authors conflicts interest declare guideline peer reviewed special interest groups across partner collaborating societies consumer organizations independently assessed agreeii criteria underwent methodological review guideline approved members guideline development groups submitted final approval nhmrc