Mengmeng Su|J. Wang|Urs Maurer|Yuping Zhang|Jun Li|Catherine McBride|Twila Tardif|Youyi Liu|Hua Shu
Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children
Beijing Normal University|Peking University|Peking University Sixth Hospital|Beijing Normal University|University of Zurich|Beijing Normal University|Chengdu Medical College|Beijing Normal University|Chinese University of Hong Kong|University of Michigan–Ann Arbor|Beijing Normal University|Beijing Normal University
ability process identify visual words requires efficient orthographic processing print consisting letters alphabetic languages characters chinese n170 robust neural marker orthographic processes genetic environmental factors home literacy shown influence orthographic processing behavioral level relative contributions interactions well understood present study aimed reveal possible genebyenvironment interactions orthographic processing behavioral neural level normal children sample sixty 12 year old chinese children 10year longitudinal sample underwent implicit visualword color decision task real words stroke combinations erp analysis focused increase occipitotemporal n170 words compared stroke combinations genetic analysis focused two snps rs1419228 rs1091047 gene dcdc2 based previous findings linking 2 snps orthographic coding home literacy measured previously number childrens books home children age 3 relative stroke combinations real words evoked greater n170 bilateral posterior brain regions significant interaction rs1091047 home literacy observed changes n170 comparing real words stroke combinations left hemisphere particularly children carrying major allele g showed similar n170 effect irrespective environment children carrying minor allele c showed smaller n170 effect low homeliteracy environment good environment