Lina Pinero Walkinshaw, Christina Hecht, Anisha Patel, Mary Podrabsky
Training High School Student "Citizen Scientists" to Document School Water Access: A Feasibility Study
The Journal of school health
radiotherapy breastconserving therapy standard postoperative treatment breast cancer carried variety irradiation techniques treatment planning must take consideration detrimental effects neighbouring organs riskthe lung heart contralateral breast include short longterm effects represented normal tissue complication probability secondary cancer risk planning study investigate intensitymodulated imrt threedimensional conformal 3dcrt radiotherapy techniques including sequential simultaneously integrated boosts well interstitial multicatheter brachytherapy boost techniques 38 patients breastconserving surgery retrospectively furthermore develop 3dprinted breast phantom addon allow catheter placement measure outoffield dose using thermoluminescent dosimeters placed inside anthropomorphic phantom finally estimate normal tissue complication probabilities using lymankutcherburman model secondary cancer risks using linear nonthreshold model outoffield model schneider et al infield results depend combination primary wholebreast irradiation boost technique normal tissue complication probabilities various endpoints following order 12 symptomatic pneumonitis ipsilateral lung 23 symptomatic pneumonitis whole lung 12 radiation pneumonitis grade 2 whole lung additional relative risk ischemic heart disease ranges 25 35 infield secondary cancer risk ipsilateral lung leftsided treatment around 50 per 10000 personyears 20 years exposure age 55 outoffield estimation secondary cancer risk results approximately 5 per 10000 personyears contralateral lung breast general 3dcrt shows best risk reduction contrast imrt regarding boost concepts brachytherapy effective method order minimise normal tissue complication probability secondary cancer risk compared teletherapy boost concepts hence 3dcrt technique combination interstitial multicatheter brachytherapy boost suitable terms risk avoidance treating breast cancer techniques including boost concepts