Arlene Bardeguez|Jane C. Lindsey|Maureen Shannon|Ruth Tuomala|Susan E. Cohn|Elizabeth Smith|Alice Stek|Shelly Buschur|Amanda Cotter|Linda Bettica|Jennifer S. Read
Adherence to Antiretrovirals Among US Women During and After Pregnancy
University of Southern California|Harvard University|Baylor College of Medicine|University of Hawaii System|University of Miami|Brigham and Women's Hospital|National Institutes of Health|University of Rochester Medical Center|National Institute of Allergy and Infectious Diseases|National Institutes of Health|University of Southern California|Harvard University|Baylor College of Medicine|University of Hawaii System|University of Miami|University of Southern California|Brigham and Women's Hospital|National Institutes of Health
background antiretrovirals arvs recommended maternal health reduce hiv1 mothertochild transmission suboptimal adherence counteract benefits objectives describe antepartum postpartum adherence arv regimens factors associated adherence methods assessed adherence rates among subjects enrolled pediatric aids clinical trials group protocol 1025 august 2002 july 2005 tablet formulations least one selfreport adherence assessment perfectly adherent subjects reported missed doses 4 days study visit generalized estimating equations used compare antepartum postpartum adherence rates identify factors associated perfect adherence results 519 eligible subjects 334445 75 reported perfect adherence pregnancy rate significantly decreased 6 24 48 weeks postpartum 185284 65 76118 64 4264 66 respectively p 001 pregnant subjects perfect adherence lower viral loads odds perfect adherence significantly higher women initiated arvs pregnancy p 001 aids p 002 never missed prenatal vitamins p 001 never used marijuana p 005 felt happy time p 001 conclusions perfect adherence arvs better antepartum overall rates low interventions improve adherence pregnancy needed