Anita Conforti|Davide Costantini|Francesca Zanetti|Ugo Moretti|Matteo Grezzana|Roberto Leone
Adverse drug reactions in older patients: an Italian observational prospective hospital study
University of Verona|University of Verona|University of Verona|University of Verona|University of Verona|University of Verona
backgroundin adults 65 years age frequency adverse drug reaction adrs related hospital admissions higher younger adults frequency adrs occurring hospital stay highly rangesthe review designed evaluate frequency adrs resulting hospital admission occurring hospital stay older patients identifying types reactions associated drugsmethods age sex date diagnosis admission patients aged 65 admitted three geriatric wards university hospital verona italy february july 2009 registered nurses special formin specific cases admissions caused adr well cases adr occurring hospital stay type reactions suspected drugs also registered nurses physicians involved studyresults six months study 1023 patients matched inclusion criteria included studyone hundred fourteen hospital admissions 111 caused adrs 256 patients 250 adr hospital staythe duration hospital stay significantly longer patients developed adr time hospital 187 95 ci 172201days versus 126 95 ci 119133dayselectrolyte disorders gastrointestinal disorders anemia international normalized ratio increase frequent observed adrs diuretics antithrombotic agents antibacterials main involved drugsour study confirms adrs important cause hospitalization older patientsin addition frequency adrs occurring hospital stay high causes prolonged hospitalization