Cristina Borradori Tolsa|Slava Zimine|Simon K. Warfield|Monica Freschi|Ana Sancho Rossignol|François Lazeyras|Sylviane Hanquinet|Mirjam Pfizenmaier|Petra S. Hüppi
Early Alteration of Structural and Functional Brain Development in Premature Infants Born with Intrauterine Growth Restriction
University Hospital of Geneva|Brigham and Women's Hospital|Harvard University|University Hospital of Geneva|University Hospital of Geneva|University Hospital of Geneva
placental insufficiency fetal intrauterine growth restriction iugr important cause perinatal mortality morbidity subsequently associated significant neurodevelopmental impairment cognitive function attention capacity school performance underlying biologic cause association unclear twentyeight preterm infants gestational age 325 19 wk studied early term magnetic resonance imaging mri advanced quantitative volumetric threedimensional mri technique used measure brain tissue volumes 14 premature infants placental insufficiency defined abnormal antenatal doppler measurements mean birth weights 10th percentile 1246 299 g iugr 14 preterm infants matched gestational age normal mean birth weights 1843 246 g control functional outcome measured term infants specialized assessment scale preterm infant behavior premature infants iugr significant reduction intracranial volume mean sd 2537 299 versus 3005 435 ml p 001 cerebral cortical gray matter mean sd 772 163 versus 1068 246 ml p 001 measured within first 2 wk life compared control premature infants findings persisted term intracranial volume mean sd 4293 479 versus 4759 534 ml p 005 cerebral cortical gray matter mean sd 1493 292 versus 189 342 ml p 001 behavioral assessment term showed significantly less mature score subsystem attentioninteraction availability iugr infants p 001 cerebral cortical gray matter volume term correlated attentioninteraction capacity measured term r 045 p 005 results suggest placental insufficiency iugr specific structural functional consequences cerebral cortical brain development findings may provide insight structuralfunctional correlate developmental deficits associated iugr