Michael J. Murray|Wanzhu Tu|Jia Rong Wu|Dan Morrow|Frederick Smith|D. Craig Brater
Factors Associated With Exacerbation of Heart Failure Include Treatment Adherence and Health Literacy Skills
University of North Carolina at Chapel Hill|Regenstrief Institute|Indiana University – Purdue University Indianapolis|Indiana University – Purdue University Indianapolis|University of Illinois Urbana-Champaign|Regenstrief Institute|Indiana University – Purdue University Indianapolis
determined factors associated exacerbation heart failure using cohort n 192 nested within randomized trial universityaffiliated ambulatory practice factors associated emergency hospital care included left ventricular ejection fraction hematocrit serum sodium levels refill adherence ability read prescription label refill adherence 40 associated threefold higher incidence hospitalization heart failure refill adherence 80 p 0002 multivariable analysis prescription label reading skills associated lower incidence heart failurespecific emergency care incidence rate ratio 076 95 confidence interval ci 019069 participants adequate health literacy lower risk hospitalization heart failure incidence rate ratio 034 95 ci 015076 conclude inadequate treatment adherence health literacy skills key factors exacerbation heart failure findings emphasize need careful instruction patients medications clinical pharmacology therapeutics 2009 85 6 651658 doi101038clpt20097