Karlota Borges|Cathryn Sibbald|Neesha Hussain?Shamsy|Jovanka Vasilevska?Ristovska|Tonny Banh|Vaidehi Patel|Josefina Brooke|Monica Piekut|Michele Reddon|Kimberly Aitken-Menezes|Ashley McNaughton|Rachel Pearl|Valérie S. Langlois|Seetha Radhakrishnan|Christoph Licht|Tino D. Piscione|Leo Levin|Damien Noone|Diane Hébert|Rulan S. Parekh
Parental Health Literacy and Outcomes of Childhood Nephrotic Syndrome
Institute for Clinical Evaluative Sciences|University of Toronto|Institute for Clinical Evaluative Sciences|Institute for Clinical Evaluative Sciences|Institute for Clinical Evaluative Sciences|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Pediatric Nephrology of Alabama|Pediatric Nephrology of Alabama|Pediatric Nephrology of Alabama|Pediatric Nephrology of Alabama|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Brampton Civic Hospital|William Osler Health System|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Pediatric Nephrology of Alabama|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Hospital for Sick Children|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|University of Toronto|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Institute for Clinical Evaluative Sciences|Pediatric Nephrology of Alabama|Institute for Clinical Evaluative Sciences|University of Toronto|Pediatric Nephrology of Alabama|University Health Network|Public Health Ontario
objective determine association parental health literacy treatment response among children nephrotic syndrome methods cohort study children aged 118 nephrotic syndrome parent health literacy measured using validated short test functional health literacy adults assessing reading comprehension numeracy outcomes included initial relapsefree period frequently relapsing disease relapse rate secondline medication use complete remission therapy results 190 parents 80 adequate health literacy score ampgt67 100 higher scores correlated higher education almost achieved perfect numeracy scores ampgt86 numeracy associated outcomes adjusting immigration education income higher reading comprehension scores tertile 3 compared lower scores tertile 1 significantly associated lower risk first relapse hazard ratio 067 95 confidence interval ci 048094 p trend 02 lower odds frequently relapsing disease odds ratio 038 95 ci 021070 p trend 002 lower relapse rate rate ratio 077 95 ci 073080 p trend amplt 001 higher odds complete remission initial steroids cyclophosphamide 207 95 ci 136316 p trend 003 597 95 ci 242147 p trend amplt 001 conclusions lower parental health literacy specifically reading comprehension associated higher relapse rates among children nephrotic syndrome fewer achieving complete remission underscores importance assessing targeting health literacy chronic management childhoodonset diseases