Jamie M Faro, Emily V Dressler, Carol Kittel, Dori M Beeler, Shirley M Bluethmann, Stephanie J Sohl, Andrew M McDonald, Kathryn E Weaver, Chandylen Nightingale
Availability of cancer survivorship support services across the National Cancer Institute Community Oncology Research Program network
JNCI cancer spectrum
alzheimers disease ad genetic risk factors indices cognitive reserve cr influence risk cognitive decline remains unclear whether interact study examined whether cr index score modifies relationship ad genetic risk factors longterm cognitive trajectories large sample individuals normal cognition analyses used data preclinical ad consortium including harmonized data 5 longitudinal cohort studies participants cognitively normal baseline baseline age 64 years 59 female underwent 10 years followup average ad genetic risk measured apolipoproteine apoe genetic status apoe2 apoe4 vs apoe3 n 1819 ii ad polygenic risk scores adprs n 1175 cr index calculated combining years education literacy scores longitudinal cognitive performance measured harmonized factor scores global cognition episodic memory executive function mixedeffects models higher cr index scores associated better baseline cognitive performance cognitive outcomes apoe4 genotype adprs included apoe region adprsapoe associated declines cognitive domains whereas adprs excluded apoe region adprswoapoe associated declines executive function global cognition memory significant 3way cr index score apoe4 time interactions global p 004 effect size 016 memory scores p 001 effect size 022 indicating negative effect apoe4 genotype global episodic memory score change attenuated among individuals higher cr index scores contrast levels cr attenuate apoe4related declines executive function declines associated higher adprs apoe2 genotype unrelated cognition results suggest apoe4 nonapoe4 ad polygenic risk independently associated global cognitive executive function declines among individuals normal cognition baseline apoe4 associated declines episodic memory importantly higher levels cr may mitigate apoe4related declines cognitive domains future research needed address study limitations including generalizability due cohort demographic characteristics