Ronald J Swatzyna, Lorrianne M Morrow, Diana M Collins, Emma A Barr, Alexandra J Roark, Robert P Turner
Evidentiary Significance of Routine EEG in Refractory Cases: A Paradigm Shift in Psychiatry
Clinical EEG and neuroscience
genomic variation impact normal biological function complex ways understanding variant effects requires broad range data coherently assimilated whilst volume human variant data relevant annotations increased corresponding increase breadth participating fields standards versioning mean moving genomic coding protein structure positions increasingly complex turn makes investigating variants diverse formats assimilating annotations different resources challenging protvar addresses issues facilitate contextualization interpretation human missense variation unparalleled flexibility ease accessibility use broadest range researchers precalculating possible variants human proteome offers near instantaneous mapping relevant data types also combines data analyses plethora resources bring together genomic protein sequence function annotations well structural insights predictions better understand likely effect missense variation humans offered intuitive web server httpswwwebiacukprotvar data explored downloaded accessed programmatically via api