Krishani Jayasinghe, W A S Chamika, Kaushalya Jayaweera, Kalpani Abhayasinghe, Lasith Dissanayake, Athula Sumathipala, Jonathan Ives
All you Need is Trust? Public Perspectives on Consenting to Participate in Genomic Research in the Sri Lankan District of Colombo
Asian bioethics review
circadian clocks coordinate behavioral physiological processes daily lightdark cycles driving rhythmic transcription thousands genes whereas master clock brain set light pacemakers peripheral organs liver reset food availability although setting entrainment mechanisms remain mysterious studying mouse fibroblasts demonstrated nutrientresponsive adenosine monophosphateactivated protein kinase ampk phosphorylates destabilizes clock component cryptochrome 1 cry1 mouse livers ampk activity nuclear localization rhythmic inversely correlated cry1 nuclear protein abundance stimulation ampk destabilized cryptochromes altered circadian rhythms mice ampk pathway genetically disrupted showed alterations peripheral clocks thus phosphorylation ampk enables cryptochrome transduce nutrient signals circadian clocks mammalian peripheral organs