Samane Shirahmadi, Saeed Bashirian, Ali Reza Soltanian, Akram Karimi-Shahanjarini, Farshid Vahdatinia
Effectiveness of theory-based educational interventions of promoting oral health among elementary school students
BMC public health
purpose overview perform exploratory analysis inhouse drugdrug interaction ddi studies conducted investigational drugs oral midazolam assess value measuring 1ohmidazolam 1ohm studies perpetrator effect investigational drugs cytochrome p450 3a cyp3a assessed analyzing midazolam 1ohm plasma evaluating pharmacokinetic parameters given almost exclusive metabolism parent drug cyp3a main metabolite 1ohm increase midazolam decrease 1ohm exposure case cyp3a inhibition caused perpetrator drug would expected opposite would anticipated case cyp3a induction analysis perpetrator potential eight different investigational drugs incorporated among 10 studies included identified cyp3a inhibitors n 4 inducers n 1 classified based data generated midazolam per se 1ohm levels contributing interpretation data corroborate findings parent compound therefore concluded continued analysis 1ohm plasma may questionable add value interpretation results performing cyp3a ddi studies investigational drug perpetrator