B R Dunn, J Bartscher, M Turaniczo, P Gram
Relationship between conjugate lateral eye movements, brain organization, and cognitive style
Brain and cognition
perioperative 5fu leucovorin oxaliplatin docetaxel flot recommended resectable esophagogastric adenocarcinoma based randomised trials however effectiveness flot routine clinical practice remains unknown randomised trials subject selection bias limiting generalisability aim study evaluate implementation flot realworld patients retrospectively collected data analysed consecutive patients treated implementation flot primary endpoint complete pathological response pcr secondary endpoints marginfree resection r0 overall survival os relapsefree survival rfs tolerability chemotherapy surgical complications mean followup time patients treated flot n 205 377 versus 470 months epirubicin cis oxaliplatin capecitabine ecxeox n 186 surgical resection performed 880 versus 920 pcr observed 38 versus 24 r0 resections achieved 780 versus 860 p 003 ecxeox flot cohorts respectively survival analysis indicated significant difference rfs p 017 os p 037 cohorts trend towards increased os performance status 0 hazard ratio hr 073 95 confidence interval ci 050104 patients treated ecxeox completed chemotherapy 39 vs 28 p 002 febrile neutropenia common flot cohort 38 vs 11 p 00086 90days mortality 12 vs 0 frequency anastomotic leakage 8 vs 6 equal low patients receiving flot demonstrate improved pcr rfs os however r0 rate improved patients good ps trended towards improved os