Rebecca Fliorent, Alicia Podwojniak, Lianne Adolphe, Katharine Milani
Racial Differences in Perceived Risk and Sunscreen Usage
Cureus
novel hot melt direct pelletization method developed characterized optimized using statistical thinking experimental design tools mixtures carnauba wax cw hpmc k100m spheronized using melted gelucire 5013 binding material bm experimentation performed sequentially fractional factorial design set initially screen factors affecting process namely spray rate quantity bm rotor speed type rotor disk lubricantglidant presence additional spheronization time powder feeding rate quantity eight factors assessed three studied process optimization spray rate quantity bm powder feeding rate different ratios solid mixture cw hpmc k100m study demonstrated novel hot melt process fast efficient reproducible predictable therefore adopted lean agile manufacturing setting production flexible pellet dosage forms various release rates easily customized immediate modified delivery