Daniel Aranda, Leila Mohammadi, Mireia Montaña Blasco, Elisenda Estanyol, Pedro Fernández-de-Castro
A dataset about Spanish young people's digital skills, use of technology and online platforms
F1000Research
cognitive impairment ci common people ms pwms evidence lacking selfreported cis mediation effect employment status objective cognitive performance selfreported ci found unreliable seemed associated depression rather formal cognitive performance hypothesized link subjective objective assessments cognitive functions mood employment status may complex pwms previously reported aims study following romeropinel et al 2022 determine whether employment status could affect performance cognitive function testing rao et al 1991 whether relationship may mediated selfreported ci deluca et al 2013 determine whether selfreported depression interacts selfreported ci influencing performance various cognitive domains pwms retrospective study performed involving pwms completed selfreport multiple sclerosis neuropsychological questionnaire msnq hospital anxiety depression scaledepression scale hadsd minimal assessment cognitive function ms macfims data regarding employment status included pwms classified employed unemployed structural equation modeling sem approach taken due advantage examining multiple cognitive outcomes simultaneously accounting shared associations first latent factor memory executive functioning modeled errorfree associations factors processing speed task sdmt next model tested indirect effect selfreported cognition msnq employment status differences outcome memory speed executive functioning finally tested interactions msnq hadsd outcomes included 590 pwms 725 female mean age 442 years sd 105 mean disease duration 86 years sd 90 majority n 455 771 relapsing ms 357 605 employed half n 301 51 report ci msnq 213 708 employed mean msnq employed pwms 245 sd 107 298 sd 112 unemployed pwms employed pwms significantly better memory 16 p 05 executive functioning 25 p 05 processing speed 22 p 05 msnq partially indirectly mediated effect employment status memory 03 p 05 executive functioning 03 p 05 processing speed 04 p 05 indicating selfreport ci partially explains influence employment status cognitive domains association msnq memory executive functioning moderated depression meaning pwms high hadsd scores msnq strongly related worse memory executive functioning final model acceptable fit data 287 46507 p 05 cfi 90 rmsea 08 90 ci 06 09 srmr 05 explaining 4120 3850 3340 variability memory executive functioning processing speed respectively selfreported ci partially explains associations employment status objective cognitive assessment pwms depression may moderate relationship selfreported cognitive assessment objective cognitive performance thus employment status mood may guide interpretation selfreported ci