Senthil K. Vasan|Tove Fall|Matt J. Neville|Belavendra Antonisamy|Caroline Fall|Finney S. Geethanjali|Harvest F. Gu|P. Raghupathy|Prasanna Samuel|Thomas Nicolaï|Kerstin Brismar|Erik Ingelsson|Fredrik Karpe
Associations of Variants in <i>FTO</i> and Near <i>MC4R</i> With Obesity Traits in South Asian Indians
Karolinska Institutet|Christian Medical College & Hospital|Karolinska Institutet|Oxford Centre for Diabetes, Endocrinology and Metabolism|Christian Medical College & Hospital|MRC Epidemiology Unit|Christian Medical College & Hospital|Karolinska Institutet|Christian Medical College & Hospital|Christian Medical College & Hospital|Christian Medical College & Hospital|Karolinska Institutet|Karolinska Institutet|Christian Medical College & Hospital|Oxford BioMedica (United Kingdom)|Oxford Centre for Diabetes, Endocrinology and Metabolism
recent genomewide association studies show loci fto melanocortin 4 receptor mc4r associate obesityrelated traits outside western populations associations variants always consistent indians suggested fto relates diabetes without obvious intermediary obesity phenotype investigated association genetic variants fto rs9939609 near mc4r rs17782313 obesity type 2 diabetes t2dmrelated traits longitudinal birth cohort 2151 healthy individuals vellore birth cohort south india fto locus displayed significant associations several conventional obesityrelated anthropometric traits per allele increase 1 bmi waist circumference wc hip circumference hc waisthip ratio consistent associations observed adipose tissuespecific measurements skinfold thickness reinforcing association obesityrelated traits obesity associations mc4r locus weak nonsignificant signal height p 0001 observed effect obesityrelated traits fto seen adulthood younger ages loci also showed nominal associations increased blood glucose associations lost bmi adjustment effect fto obesityrelated traits driven urban environmental influence conclude rs9939609 variant fto locus associated measures adiposity metabolic consequences south indians enhanced effect associated urban living detection associations indians challenging conventional anthropometric obesity measures work poorly indian thinfat phenotype