Ronny Wickström|Béatrice Skiöld|Gunilla Petersson|Olof Stephansson|Maria Altman
Moderate neonatal hypoglycemia and adverse neurological development at 2–6 years of age
Karolinska Institutet|Karolinska Institutet|Karolinska Institutet|Karolinska Institutet|Karolinska Institutet
determine whether moderate neonatal hypoglycemia otherwise healthy infants associated adverse neurodevelopmental outcome preschool children populationbased cohort study prospectively collected register data sweden singletons born july 1st 2008 december 31st 2012 n 101060 region included infants congenital malformations infants treated neonatal intensive care unit infants inborn errors metabolism infants mothers diabetes excluded infants followedup 2014 26 years age exposure neonatal moderate hypoglycemia main outcomes compiled neurological neurodevelopmental outcome developmental delay motor developmental delay cognitive developmental delay adjusted regression analyses odds ratio neurological neurodevelopmental outcome 148 95 confidence interval 117188 hypoglycemic compared normoglycemic infants adjusted risk developmental delay doubled 253 171373 adjusted risk motor developmental delay almost doubled 191 106344 adjusted risk cognitive developmental delay almost tripled 285 170476 infants early neonatal hypoglycemia 6 h double risk 194 130289 neurological neurodevelopmental outcome tripled risk cognitive developmental delay 317 135743 compared normoglycemic infants first populationbased study topic show moderate neonatal hypoglycemia associated increased risks impaired neurodevelopment current treatment routines uncomplicated hypoglycemia followed