Ron Strochlic, Lauren E Au, Lorrene Ritchie
Is urban-rural location associated with weight status in school children? An examination of 42 small and rural Californian counties
Rural and remote health
investigate whether age first sexual intercourse could lead changes risk oral cavity cancer twosample mendelian randomization conducted using genetic variants associated age first sexual intercourse uk biobank instrumental variables summary data northern american previous genomewide association study aimed oral cavity cancer served outcome three analytical methods inverse varianceweighted mendelian randomization egger weighted median used perform analysis among inverse varianceweighted set primary method robustness results assessed cochran q test mendelian randomization egger intercept tests mr presso leave one analysis funnel plot primary analysis provided substantial evidence positive causal relationship age first sexual intercourse risk oral cavity cancer p 00002 delayed age first sexual intercourse would lead decreased risk suffering oral cavity cancer 1013 secondary outcomes confirmed results 0 assessments supported robustness p 005 study demonstrates delayed sexual debut would provide protection occ thus education delaying sexual intercourse recommended