Héctor Raúl Olivares-Sánchez, Carlos Manuel Rodríguez-Martínez, Héctor Francisco Coronel-Brizio, Enrico Scalas, Thomas Henry Seligman, Alejandro Raúl Hernández-Montoya
An empirical data analysis of "price runs" in daily financial indices: Dynamically assessing market geometric distributional behavior
PloS one
preliminary evidence highlighted possible association severe covid19 persistent cognitive deficits research required confirm association determine whether cognitive deficits relate clinical features acute phase mental health status point assessment quantify rate recovery 46 individuals received critical care covid19 addenbrookes hospital 10th march 2020 31st july 2020 16 mechanically ventilated underwent detailed computerised cognitive assessment alongside scales measuring anxiety depression posttraumatic stress disorder supervised conditions mean follow 60 21 months following acute illness patient matched control n 460 performances transformed standard deviation expected scores accounting age demographic factors using n 66008 normative datasets global accuracy response time composites calculated gsscore grt linear modelling predicted composite score deficits acute severity mentalhealth status assessment time hospital admission pattern deficits across tasks qualitatively compared normal agerelated decline earlystage dementia covid19 survivors less accurate gsscore053sds slower grt089sds responses expected compared matched controls acute illness chronic mental health significantly predicted cognitive deviation expected scores gsscore p00037 grt p 00366 prominent task associations covid19 higher cognition processing speed qualitatively distinct profiles normal ageing dementia similar magnitude effects ageing 50 70 years age trend towards reduced deficits time illness r015 reach statistical significance cognitive deficits severe covid19 relate strongly acute illness severity persist long chronic phase recover slowly characteristic profile highlighting higher cognitive functions processing speed work funded national institute health research nihr cambridge biomedical research centre brc nihr cambridge clinical research facility brc121520014 addenbrookes charities trust nihr covid19 bioresource rg9402 ah funded uk dementia research institute care research technology centre imperial college london biomedical research centre etb dkm supported nihr senior investigator awards jbr supported wellcome trust 220258 medical research council suag051 g101400 vfjn funded academy medical sciences health foundation clinician scientist fellowship views expressed authors necessarily nhs nihr department health social care