K Liu, H Y Yuan, S S Shen, J Liu, X Y Wang, C Chen, X M Zhong
[Relationship between health literacy and health-related behaviors of enterprise employees]
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
earliest onset puberty shifted downward may due role early growth development factors childhood 1575 kindergarten two k2 children anhui province china followed elementary school girls n 342 available data ar breast development included analysis polygenic risk score prs computed based 17 single nucleotide polymorphisms early puberty accelerate failure time aft model used describe thelarche timing early ar among girls different polygenic susceptibility adjustment perinatal anthropometric household income parental education prepuberty bmiz score puberty started 412month earlier early ar girls compared normal ar girls tr 096 95 ci 095 098 p 0001 furthermore pubertyaccelerating effect observed among girls high 606month earlier tr 094 95 ci 090 099 moderate prs 420month earlier tr 096 95 ci 093 098 similar results observed low prs groups tr 100 95 ci 096 104 girls early ar displayed younger age thelarche however accelerating effect observed among genetic susceptibility early puberty early ar plays important role predicting earlier thelarche among girls high moderate prs study combined hot topics pubertalrelated polygenic risk score prs pubertal timing examine longitudinal association early ar accelerated pubertal onset results mean accelerating growth early childhood years birth might forecast early puberty among girls genetic predisposition early puberty prevention strategies management options emphasized target early childhood address secular trend early puberty observed past decades china