Richard J Wang, Michael A White, Bret A Payseur
The Pace of Hybrid Incompatibility Evolution in House Mice
Genetics
irritability foundational clinical reasoning concept rehabilitation evaluate reactivity examination treatment originally theorized reflect tissue damage large body evidence supports pain biopsychosocial experience impacted pain sensitivity psychological factors therefore purpose study examine biopsychosocial contributors irritability 40 patients shoulder n 20 low back n 20 pain underwent quantitative sensory testing qst pressure pain threshold heat pain threshold conditioned pain modulation temporal summation completed painrelated psychological questionnaires exerciseinduced hypoalgesia protocol standardized irritability assessment based clinical practice guidelines participants categorized irritable irritable based maitlands criteria irritability level based clinical practice guidelines independent samples ttest examined differences qst psychological factors irritability category manova examined differences qst psychological factors irritability level high moderate low significantly lower heat pressure pain thresholds multiple locations p 005 well less efficient conditioned pain modulation p 002 demonstrated individuals categorized irritable heat pressure pain thresholds also significantly lower patients high irritability compared levels significantly higher depression anger well lower selfefficacy reported individuals irritable presentation biopsychosocial factors including widespread hyperalgesia elevated psychological factors may contribute irritable presentation