Stephen A. Semick|Rahul Bharadwaj|Leonardo Collado?Torres|Ran Tao|Joo Heon Shin|Amy Deep?Soboslay|James R. Weiss|Daniel R. Weinberger|Thomas M. Hyde|Joel E. Kleinman|Andrew E. Jaffe|Venkata S. Mattay
Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease
Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development|Johns Hopkins University|Johns Hopkins Medicine|Lieber Institute for Brain Development|Johns Hopkins Medicine|Johns Hopkins University|Lieber Institute for Brain Development
lateonset alzheimers disease ad complex agerelated neurodegenerative disorder likely involves epigenetic factors better understand epigenetic state associated ad surveyed 420852 dna methylation dnam sites neurotypical controls n 49 lateonset ad patients n 24 across four brain regions hippocampus entorhinal cortex dorsolateral prefrontal cortex cerebellum identified 858 sites robust differential methylation collectively annotated 772 possible genes fdr 5 within 10 kb sites overrepresented ad genetic risk loci p 000655 enriched changes normal aging p 22 1016 nearby genes enriched processes related celladhesion immunity calcium homeostasis fdr 5 functionally validate associations generated analyzed corresponding transcriptome data prioritize 130 genes within 10 kb differentially methylated sites 130 genes differentially expressed ad cases controls expression associated nearby dnam p 005 integrated analysis implicates novel genes alzheimers disease ankrd30b results highlight dnam differences alzheimers disease gene expression correlates implicating dnam epigenetic mechanism underlying pathological molecular changes associated ad furthermore framework illustrates value integrating epigenetic transcriptomic data understanding complex disease