Jason M. Beneciuk|Jonathan Hill|Paul Campbell|Ebenezer Afolabi|Steven Z. George|Kate M. Dunn|Nadine E Foster
Identifying Treatment Effect Modifiers in the STarT Back Trial: A Secondary Analysis
University of Florida|Keele University|Keele University|Keele University|University of Florida|Keele University|Keele University
identification patient characteristics influencing treatment outcomes top low back pain lbp research priority results start back trial support effectiveness prognostic stratified care lbp compared current best care however patient characteristics associated treatment response yet explored purpose secondary analysis identify treatment effect modifiers within start back trial 4month followup n 688 treatment response dichotomized using backspecific physical disability measured using rolandmorris disability questionnaire 7 candidate modifiers identified using previous literature evaluated using logistic regression statistical interaction terms provide preliminary evidence treatment effect modification socioeconomic status ses identified effect modifier disability outcomes odds ratio 171 p 028 high ses patients receiving prognostic stratified care 25 times less likely poor outcome compared low ses patients receiving best current care 40 p 006 education level 133 p 109 number pain medications 64 p 140 met criteria effect modification weaker evidence 20 p 05 findings provide preliminary evidence ses education number pain medications treatment effect modifiers prognostic stratified care delivered start back trial perspective analysis provides preliminary exploratory findings characteristics patients might least likely benefit targeted treatment using prognostic stratified care lbp