Luke E. Grzeskowiak|Brian J. Smith|Anil Roy|Gustaaf Dekker|Vicki L. Clifton
Patterns, predictors and outcomes of asthma control and exacerbations during pregnancy: a prospective cohort study
University of Adelaide|Queen Elizabeth Hospital|Queen Elizabeth Hospital|University of Adelaide|University of Adelaide|Mater Research|University of Queensland
exists paucity data socially disadvantaged populations describing patterns predictors asthma control status exacerbations pregnancy relationship adverse perinatal outcomes asthmatic women n189 followed prospectively pregnancy visits 12 20 28 36 weeks gestation data loss control recurrent uncontrolled asthma moderatesevere exacerbations collected visit relationship perinatal outcomes examined following stratification fetal sex 50 asthmatic women experienced loss control moderatesevere exacerbation pregnancy 22 women experiencing moderatesevere exacerbation factors associated increased risk women experiencing recurrent uncontrolled asthma pregnancy included smoking relative risk 292 95 ci 153558 inhaled corticosteroid use beginning pregnancy relative risk 240 95 ci 125460 increasing maternal age relative risk 106 95 ci 101111 factors associated moderatesevere exacerbations asthma control rather exacerbations pregnancy appeared strongly correlated perinatal outcomes following stratification fetal sex presence recurrent uncontrolled asthma associated increased risk small gestational age women pregnant females 333 versus 95 p0018 contrast nonsignificant increased risk preterm birth women recurrent uncontrolled asthma pregnant males 250 versus 118 p0201 results suggest key improving perinatal outcomes lies improving asthma control early possible pregnancy monitoring throughout pregnancy rather focusing preventing exacerbations alone