Jaime Carcamo-Oyarzun, Sonia Salvo-Garrido, Isaac Estevan
Actual and Perceived Motor Competence in Chilean Schoolchildren before and after COVID-19 Lockdowns: A Cohort Comparison
Behavioral sciences (Basel, Switzerland)
dysregulation gut microbiome implicated parkinsons disease pd study aimed evaluate clinical effects safety single faecal microbiota transplantation fmt patients earlystage pd gutparfect trial singlecentre randomised doubleblind placebocontrolled trial conducted ghent university hospital december 01 2020 december 12 2022 participants aged 5065 years hoehn yahr stage 2 randomly assigned receive nasojejunal fmt either healthy donor stool stool computergenerated randomisation done 11 ratio permutatedblock scheduling treatment allocation concealed participants investigators primary outcome measure 12 months change movement disorders societyunified parkinsons disease rating scale mdsupdrs motor score obtained offmedication evaluations intentiontotreat analysis performed using mixed model repeated measures analysis completed trial registered clinicaltrialsgov nct03808389 december 2020 december 2021 fmt procedures conducted 46 patients pd 22 healthy donor group 24 placebo group clinical evaluations performed baseline 3 6 12 months postfmt full data analysis possible 21 participants healthy donor group 22 placebo group 12 months mdsupdrs motor score significantly improved mean 58 points 95 ci 114 02 healthy donor group 27 points 83 29 placebo group p 00235 adverse events limited temporary abdominal discomfort findings suggested single fmt induced mild longlasting beneficial effects motor symptoms patients earlystage pd findings highlight potential modulating gut microbiome therapeutic approach warrant exploration fmt larger cohorts patients pd various disease stages flemish pd patient organizations vpl parkili research foundation flanders fwo biocodex microbiota foundation