Morgan Butrick|Debra Roter|Kimberly A. Kaphingst|Lori H. Erby|Carlton Haywood|Mary Catherine Beach|Howard P. Levy
Patient reactions to personalized medicine vignettes: An experimental design
Johns Hopkins University|National Human Genome Research Institute|Johns Hopkins University|Washington University in St. Louis|Johns Hopkins University|Johns Hopkins Berman Institute of Bioethics|Johns Hopkins University|Johns Hopkins Berman Institute of Bioethics|Johns Hopkins University
purposetranslational investigation personalized medicine infancy exploratory studies reveal attitudinal barriers racebased medicine cautious optimism regarding genetically personalized medicine study describes patient responses hypothetical conventional racebased genetically personalized medicine prescriptionsmethodsthree hundred eightyseven participants mean age 47 years 46 white recruited baltimore outpatient center randomized vignettebased experimental study asked imagine doctor diagnosing condition prescribing one three medications outcomes emotional response vignette belief vignette medication efficacy experience respect trust vignette physician adherence intentionresultsracebased medicine vignettes appraised negatively conventional vignettes across board cohens 051057064 p 0001 participants rated genetically personalized comparably conventional medicine 014015017 p 047 exception reduced adherence intention genetically personalized medicine cohens 038041044 p 0009 relative reluctance take genetically personalized medicine pronounced racial minorities cohens 038031025 p 002 related trust vignette physician change r2 023 p 0001conclusionthis study demonstrates relative reluctance embrace personalized medicine technology especially among racial minorities highlights enhancement adherence improved doctor patient relationships