Durgesh Wankhede, Tanwei Yuan, Matthias Kloor, Niels Halama, Hermann Brenner, Michael Hoffmeister
Clinical significance of combined tumour-infiltrating lymphocytes and microsatellite instability status in colorectal cancer: a systematic review and network meta-analysis
The lancet. Gastroenterology & hepatology
studies congenital anomalies provide prevalence estimates stratified maternal raceethnicity sought determine whether prevalence broad spectrum anomalies varies among offspring women different raceethnic groups obtained information cases anomalies populationbased texas birth defects registry denominator data livebirths among texas residents 19992018 texas center health statistics estimated prevalence ratio pr 95 confidence interval ci n 145 anomalies among offspring hispanic nonhispanic black relative nonhispanic white women using poisson regression adjusting maternal age education body mass index previous livebirths performed twostage analysis bonferroniadjusted p 17 104 initial screening phase identify anomalies statistically significant variation 7698768 livebirths 1187385 anomalies diagnosed 368393 cases prevalence monitored congenital anomaly similar among offspring nonhispanic white referent nonhispanic black pr 098 ci 096100 hispanic pr 095 ci 093096 women observed statistically significant racialethnic variation 42 anomalies marked differences observed comparing offspring nonhispanic black nonhispanic white women respect polydactyly pr 438 ci 407472 pyloric stenosis pr 034 ci 029040 aortic valve atresiastenosis pr 051 ci 036072 birth prevalence many major congenital anomalies varies maternal race ethnicity reasons differences likely multifactorial thorough understanding racial ethnic disparities useful stimulate etiologic research