Daniela Calina|Thomas Hartung|Anca Oana Docea|Demetrios Spandidos|A. M. Egorov|?.?. ????????|Félix Carvalho|Aristidis Tsatsakis
COVID-19 vaccines: ethical framework concerning human challenge studies
University of Medicine and Pharmacy of Craiova|University of Konstanz|University of Medicine and Pharmacy of Craiova|University of Crete|Chumakov Institute of Poliomyelitis and Viral Encephalitides|Russian Academy of Sciences|D. Mendeleyev University of Chemical Technology of Russia|Universidade do Porto|Rede de Química e Tecnologia|Russian Academy of Sciences
pandemic associated new sarscov2 coronavirus continues spread worldwide favorable epidemic control scenario provides longterm protection covid19 outbreak development distribution effective safe vaccine need develop new covid19 vaccine pressing however likely take long time possibly several years due time required demonstrate safety efficacy proposed vaccine time required manufacture distribute millions doses accelerate development associated safety testing deliberate infection healthy volunteers suggested purpose short communication describe ethical aspects type testing deliberate infection volunteers dangerous virus sarscov2 initially considered unethical researchers current pandemic different previous ones studies considered ethical certain criteria met participants human challenge studies must relatively young good health must receive highest quality medical care frequent monitoring tests also performed great caution specialized medical supervision besides fact obtaining vaccines faster deliberate infection studies healthy people greater benefits risks demonstrated obtaining vaccines historical pandemics smallpox influenza malaria typhoid fever dengue fever zika one possibility shorten time required development covid19 vaccines reduce clinical phases ii iii using human challenge studies eliberate infection healthy volunteers sarscov2 administration candidate vaccine accelerating development covid19 vaccine even weeks months would great beneficial impact public health saving many lives