Tadesse Melaku Abegaz|Abdulla Shehab|Eyob Alemayehu Gebreyohannes|Akshaya Srikanth Bhagavathula|Asim Ahmed Elnour
Nonadherence to antihypertensive drugs
Creative Commons|University of Gondar|United Arab Emirates University|Creative Commons|University of Gondar|United Arab Emirates University|Creative Commons|University of Gondar|United Arab Emirates University|Creative Commons|University of Gondar|United Arab Emirates University|Creative Commons|University of Gondar|United Arab Emirates University
background hypertension drives global burden cardiovascular disease prevalence estimated increase 30 year 2025 nonadherence chronic medication regimens common approximately 43 655 patients fail adhere prescribed regimens hypertensive patients nonadherence medications potential contributing factor occurrence concomitant diseases objective systematic review applied metaanalytic procedure investigate medication nonadherence adult hypertensive patients methods original research studies conducted adult hypertensive patients using 8item morisky medication adherence scale mmas8 assess medication adherence january 2009 march 2016 included comprehensive search strategies 3 databases mesh keywords used locate eligible literature study characteristics participant demographics medication adherence outcomes recorded effect sizes outcomes calculated standardized mean differences using randomeffect model estimate overall mean effects results total 28 studies 15 countries identified total comprising 13688 hypertensive patients reviewed 25 studies included metaanalysis involving 12603 subjects significant number 452 hypertensive patients onethird 312 hypertensive patients comorbidities nonadherent medications however higher proportion 837 medication nonadherence noticed uncontrolled blood pressure bp patients although higher percentage 54 nonadherence antihypertensive medications noticed females p 0001 risk nonadherence 13 times higher males relative risk 0883 overall nearly twothirds 625 medication nonadherence noticed africans asians 435 conclusion nonadherence antihypertensive medications noticed 45 subjects studied higher proportion uncontrolled bp 837 nonadherent medication intervention models aiming improve adherence emphasized