Kristen Murray, Jack Davey, Mosa Dennis, Darcy Harris, Erin Hayman, Elizabeth Rieger
The effect of appearance and functionality concerns, and weight status, on negative body image mental health literacy in women
Body image
arguably famous principle toxicology dose makes poison formulated paracelsus 16th century application paracelsuss principle mechanistic toxicology may challenging one compound may affect many molecular pathways different doses different often nonlinear doseresponse relationships result many mechanistic studies environmental occupational compounds use high doses xenobiotics motivated need see clear signal indicating disruption particular molecular pathway approach ignores possibility xenobiotic may affect different molecular mechanisms much lower doses relevant human exposures amend mechanistic toxicology simple concise guiding principle suggest recontextualization paracelsuss following letter spirit dose disrupts pathway justification statement includes observations many environmental occupational xenobiotics affect broad range molecular cascades molecular pathways sensitive chemical exposures different molecular pathways sensitive different doses chemical compound suggest statement may become useful guidance educational tool range toxicological applications including experimental design comparative analysis mechanistic hypotheses evaluation quality toxicological studies risk assessment