Thomas A. Wills|James D. Sargent|Frederick X. Gibbons|Ian Pagano|Rebecca J. Schweitzer
E-cigarette use is differentially related to smoking onset among lower risk adolescents
Cancer Center of Hawaii|University of Hawai?i at M?noa|University of Hawaii System|Dartmouth College|University of Connecticut|Cancer Center of Hawaii|University of Hawai?i at M?noa|University of Hawaii System|University of Hawai?i at M?noa
temperature profoundly influences various life phenomena animals developed mechanisms respond properly environmental temperature fluctuations identify genes involved sensing ambient temperature responding change gt27000 independent pelement insertion mutants idrosophilai screened result found defects genes encoding proteins involved histamine signaling histidine decarboxylase ihdci histaminegated chloride channel subunit 1 ihiscl1i ora transientless iorti cause abnormal temperature preferences abnormal preferences shown mutants restored genetic pharmacological rescue could reproduced wild type using histamine receptor inhibitors cimetidine hydroxyzine spatial expression genes observed various brain regions including pars intercerebralis fanshaped body circadian clock neurons idtrpa1iexpressing neurons essential element thermotaxis also found histaminergic mutants showed reduced tolerance high temperature enhanced tolerance cold temperature together results suggest histamine signaling may important roles modulating temperature preference controlling tolerance low high temperature