Xiaolong Ma, Wenqing Wang, Qiong Wu, Chao Zheng, Jianchao Liu, Huajuan Bai, Tianyi Zhang, Lin Li, Lihua Liu
Factors influencing length of stay and costs in inpatient cases of human brucellosis as the primary diagnosis over a decade in Beijing, China
Frontiers in public health
continuous manufacturing cm emerged pharmaceutical industry paradigm shift significant advantages related cost efficiency flexibility higher assurance quality inherent differences batch processes justify examining cm control strategy holistically article describes current thinking control implementation cm using example direct compression process taking consideration ich q10 definition state control process validation requirements statistical process control using control charts sources variation process capability process performance explained useful concept help assess impact variation within batch indicates process state control potential timevariant nature startup shutdown cm discussed assure product quality minimizing waste well different options detection isolation nonconforming materials due process upsets different levels control possible cm appropriate balance process control end product testing needed depending level process understanding different stages development production clinical supplies commercialization