Dorota Chapko|Roisin McCormack|Corri Black|Roger T. Staff|Alison Murray
Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia – a systematic literature review
University of Aberdeen|University of Aberdeen|Farr Institute|University of Aberdeen|Aberdeen Royal Infirmary|NHS Grampian|University of Aberdeen
concept cognitive reserve cr defined moderator allows individual preserve cognition despite underlying brain pathology consensus potentially modifiable cr determinants greatest importance aim review identify lifecourse factors protect older individuals expressing cognitive decline despite presence brain pathologya systematic review search performed medline 1946060913 embase 1947060913 psycheinfo 1967060913 included studies examining cr context four commonest subtypes dementia mild cognitive impairment healthy aging studies combined measurement underlying dementiarelated neuropathology cognitive function factors providing cr single model accepted performed qualitative synthesis resultsthirtyfour studies 9229 screened records met inclusion criteria therefore quality assessed data extracted variation cr definition made comparison across studies difficult one hundred fortyfour 156 models examined education occupation overall 58 eligible models classified education 60 occupation cr determinant 12 44 respectively high quality within healthy population suitable inform preventative interventions consistent evidence education protective effect general cognition face multiple brain burden measures occupation presented inconclusive results within cognitive groupsfurther research modifiable determinants cr beyond educationoccupation including earlylife factors consensus cr definition warranted