Samuel Shaki, Martin H Fischer
Competing Biases in Mental Arithmetic: When Division Is More and Multiplication Is Less
Frontiers in human neuroscience
introduction endoplasmic reticulum stress ers response accumulation unfolded proteins plays crucial role development tumors including processes tumor cell invasion metastasis immune evasion however specific regulatory mechanisms ers breast cancer bc remain unclear methods study analyzed rna sequencing data cancer genome atlas tcga breast cancer identified 8 core genes associated ers elovl2 ifng map2k6 mzb1 pcsk6 pcsk9 igf2bp1 pop1 evaluated individual expression independent diagnostic prognostic values breast cancer patients multifactorial cox analysis established risk prognostic model validated external dataset additionally conducted comprehensive assessment immune infiltration drug sensitivity genes results results indicate eight core genes play crucial role regulating immune microenvironment breast cancer brca patients meanwhile independent diagnostic model based expression eight genes shows limited independent diagnostic value independent prognostic value unsatisfactory time roc auc values generally 05 according results logistic regression neural networks risk prognosis models eight genes interact synergistically serve excellent biomarkers diagnosis prognosis breast cancer patients furthermore research findings confirmed qpcr experiments validation conclusion conclusion explored mechanisms ers brca patients identified 8 outstanding biomolecular diagnostic markers prognostic indicators research results doublevalidated using geo database qpcr