Noor Khalili Mohd Ali|Kate Lifford|Ben Carter|Fiona E. McRonald|Ghasem Yadegarfar|David R Baldwin|David Weller|David M. Hansell|Stephen W. Duffy|John K. Field|Kate Brain
Barriers to uptake among high-risk individuals declining participation in lung cancer screening: a mixed methods analysis of the UK Lung Cancer Screening (UKLS) trial
Cardiff University|Cardiff University|Cardiff University|Cardiff University|University of Liverpool|University of Liverpool|Nottingham University Hospitals NHS Trust|Royal Brompton Hospital|University of Liverpool|Cardiff University
h3objectiveh3 current study aimed identify barriers participation among highrisk individuals uk lung cancer screening ukls pilot trial h3settingh3 ukls pilot trial randomised controlled trial lowdose ct ldct screening recruited highrisk people using population approach cambridge liverpool areas h3participantsh3 highrisk individuals aged 5075 years invited participate ukls individuals excluded ldct scan performed within last year unable provide consent ldct screening unable carried due coexisting comorbidities h3outcome measuresh3 statistical associations individual characteristics ukls uptake examined using multivariable regression modelling completed nonparticipation questionnaire npq thematic analysis freetext data undertaken identify reasons taking part subsequent exploratory linkage key themes risk factors nonuptake h3resultsh3 comparative data available 4061 highrisk individuals consented participate trial 2756 declined participation declining participation 748 271 completed npq factors associated nonuptake included female gender or064 plt0001 older age or073 plt0001 current smoking or070 plt0001 lower socioeconomic group or056 plt0001 higher affective risk perception or052 plt0001 among nonparticipants provided reason two main themes emerged reflecting practical emotional barriers smokers likely report emotional barriers participation h3conclusionsh3 profile risk factors nonparticipation lung screening emerged underlying reasons largely relating practical emotional barriers strategies engaging highrisk hardtoreach groups critical equitable uptake potential future lung cancer screening programme h3trial registration numberh3 ukls trial registered international standard randomised controlled trial register reference 78513845