Renerus J Stolwyk, Tijana Mihaljcic, Dana K Wong, Diana Ramirez Hernandez, Brittany Wolff, Jeffrey M Rogers
Post-stroke Cognition is Associated with Stroke Survivor Quality of Life and Caregiver Outcomes: A Systematic Review and Meta-analysis
Neuropsychology review
multiple primary lung cancer mplc increasingly wellknown clinical phenomenon however molecular characterizations poorly understood still lacks effective method distinguish intrapulmonary metastasis im herein propose identification model based molecular multidimensional analysis order accurately optimize treatment total 112 chinese lung cancers harboring least two tumors n 270 enrolled retrospectively selected 74 patients 121 tumor pairs randomly divided tumor pairs training cohort test cohort 73 ratio novel model established training cohort optimized mplc identification using comprehensive genomic profiling analyzed broad panel 808 cancerrelated genes evaluated test cohort prospective validation cohort 38 patients 112 tumors found differences molecular characterizations two diseases rigorously selected characterizations build identification model evaluated performance classifier using test cohort data observed 895 percent agreement pa mplc 1000 percent agreement im model showed excellent area curve auc 0947 913 overall accuracy similarly assay achieved considerable performance independent validation set auc 0938 mplc predictive value 100 importantly mplc predictive value classification achieved 100 test set validation cohort compared previous mutationbased method classifier showed better consistencies clinical classification among 112 patients 084 vs 065 p 01 data provide novel evidence mplcspecific genomic characteristics demonstrate onestep molecular classifier accurately classify multifocal lung tumors mplc im suggested broad panel ngs may useful tool assisting differential diagnoses