Hwee Lin Wee|Yin?Bun Cheung|Shu?Chuen Li|Kok?Yong Fong|Julian Thumboo
The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: is the whole greater than the sum of its parts?
National University of Singapore|National Cancer Centre Singapore|National University of Singapore|Singapore General Hospital|Singapore General Hospital
diabetes mellitus dm important public health concern impact increased high prevalence coexisting chronic medical conditions among subjects dm aims study therefore 1 evaluate impact dm coexisting chronic medical conditions healthrelated quality life hrqol could additive synergistic subtractive 2 determine extent sf6d singleindex preference measure captures multidimensional information provided sf36 profile measure using data crosssectional populationbased survey chinese malay indians singapore developed 9 separate multiple linear regression models sf36 scale sf6d index score dependent variable one model influence dm second chronic medical condition hypertension htn heart disease hd musculoskeletal illnesses ms interactions studied adjusting influence potential confounding variables among 5224 subjects prevalence dm htn hd ms 59 107 24 266 respectively dm lowered sf36 scores 2 points 3 sf36 scales lowered sf6d scores 003 points subjects dm htn dm hd dm ms experienced lowering sf36 scores exceeding 2 points least 6 scales lowering sf6d scores 005 008 010 points respectively generally dm coexisting medical conditions exerted additive effects hrqol exception dm heart disease subtractive effect noted sf6d index scores generally reflected patterns influence dm chronic medical conditions sf36 scores dm chronic medical conditions generally reduced hrqol multiethnic general population additive rather synergistic subtractive fashion study sf6d reasonably good summary measure sf36