Gunnar Kaati|Lars Olov Bygren|Marcus Pembrey|Michael Sjöstróm
Transgenerational response to nutrition, early life circumstances and longevity
Umeå University|Karolinska Institutet|University College London|Karolinska Institutet
nutrition might induce loci epigenetic changes could transmitted next generation impacting health slow growth period sgp prepubertal peak growth velocity emerged sensitive period different food availability followed different transgenerational response tgr aim study investigate extent probands childhood circumstances fact determinants findings analysis data three random samples comprising 271 probands 1626 parents grandparents left exclusions missing data utilized availability food given year classified based regional statistics ancestors sgp set ages 812 years availability food years classified good intermediate poor probands childhood circumstances defined fathers ownership land number siblings order sibship death parents parents level literacy earlier finding sexspecific influence ancestors nutrition sgp going paternal grandmother female proband paternal grandfather male proband confirmed addition response father son emerged childhood social circumstances son accounted early social circumstances influenced longevity male proband tgrs ancestors nutrition prevailed main influence longevity