Hamed Khalili|Edward S. Huang|Ashwin N. Ananthakrishnan|Leslie M. Higuchi|James M. Richter|Charles S. Fuchs|Andrew T. Chan
Geographical variation and incidence of inflammatory bowel disease among US women
Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Boston Children's Hospital|Massachusetts General Hospital|Harvard University|Dana-Farber Cancer Institute|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital
geographical variation incidence crohns disease cd ulcerative colitis uc according latitude residence reported europe however comparable data usa incidence cd uc relation latitude assessed geographically diverse population women enrolled two large prospective studies usaa prospective study undertaken women enrolled nurses health study nhs 1976 nhs ii 1989 information state residence time birth age 15 years age 30 years collected 1992 nhs 1993 nhs ii reported diagnoses incident cd uc end 2003 confirmed medical record review cox proportional hazards models used calculate hrs 95 cis risk cd ucin cohorts among 175912 women reporting residence 1992 257 cases cd 313 cases uc documented 3428376 personyears followup incidence cd uc increased significantly increasing latitude ptrend001 residence age 30 years strongly associated risk compared women residing northern latitudes age 30 multivariateadjusted hr women residing southern latitudes 048 95 ci 030 077 cd 062 95 ci 042 090 uc effect latitude residence risk cd uc vary according smoking history pinteraction026 cd 099 ucin population us women increasing latitude residence associated higher incidence cd uc