Jinoos Yazdany|Edward H. Yelin|Pantelis Panopalis|Laura Trupin|Laura Julián|Patricia Katz
Validation of the systemic lupus erythematosus activity questionnaire in a large observational cohort
University of California, San Francisco
examine reliability construct validity responsiveness systemic lupus erythematosus activity questionnaire slaq large observational cohort persons systemic lupus erythematosus slewe evaluated reliability slaq using cronbachs alpha principal factor analysis ascertained construct validity studying association slaq clinically relevant validated patient assessments health estimated responsiveness calculating standardized response means analyzing association changes slaq scores changes patient assessments healththe slaq excellent reliability reflected cronbachs alpha 087 principal factor analysis one factor accounted 92 variance slaq scores strongly correlated health indices including short form 12 physical component summary short form 36 physical functioning subscale scores significantly higher respondents reporting flare disease activity hospitalization last year concurrent use immunosuppressive medication work disability slaq demonstrated small moderate degree responsiveness standardized response means 066 037 reporting clinical worsening improvement respectively across range patient assessments disease status slaq response direction predicted measuresthe slaq demonstrates adequate reliability construct validity responsiveness large communitybased cohort appears represent promising tool studies sle outside clinical setting