Lei Yu|Robert S. Wilson|Julie A. Schneider|David A. Bennett|Patricia A. Boyle
Financial and Health Literacy Predict Incident Alzheimer’s Disease Dementia and Pathology
Rush University Medical Center|Rush University Medical Center|Rush University Medical Center|Rush University Medical Center|Rush University Medical Center
background domain specific literacy multidimensional construct requires multiple resources including cognitive noncognitive factors objective test hypothesis domain specific literacy associated alzheimers disease ad dementia ad pathology controllin g cognition methods participants communitybased older persons completed baseline literacy assessment underwent annual clinical evaluations 8 years agreed organ donation death financial health literacy measured using 32 questions cognition measured using 19 tests annual diagnosis ad dementia followed standard criteria ad pathology examined postmortem quantifying plaques tangles cox models examined association literacy incident ad dementia performance model prediction incident ad dementia assessed using indices integrated discrimination improvement continuous net reclassification improvement linear regression models examined independent association literacy ad pathology autopsied participants results 805 participants free dementia baseline 102 127 developed ad dementia followup lower literacy associated higher risk incident ad dementia p 0001 association persisted controlling cognition hazard ratio 150 p 0004 model including literacy measure better predictive performance one demographics cognition lower literacy also associated higher burden ad pathology controlling cognition 007 p 0035 conclusion literacy predicts incident ad dementia ad pathology communitydwelling older persons association independent traditional measures cognition