Laureen H Smith, Christopher Holloman
Comparing the effects of teen mentors to adult teachers on child lifestyle behaviors and health outcomes in Appalachia
The Journal of school nursing : the official publication of the National Association of School Nurses
study aimed explore incidence occult lymph node metastasis olm clinical t1 2n0m0 ct1 2n0m0 small cell lung cancer sclc patients develop machine learning prediction models using preoperative intratumoral peritumoral contrastenhanced ctbased radiomic data conducting retrospective analysis involving 242 eligible patients 4 centeres determined incidence olm ct1 2n0m0 sclc patients lesion two rois defined using gross tumour volume gtv peritumoral volume 15 mm around tumour ptv extracting comprehensive set 1595 enhanced ctbased radiomic features individually gtv ptv five models constucted rigorously evaluated model performance using various metrics including area curve auc accuracy sensitivity specificity calibration curve decision curve analysis dca enhanced clinical applicability formulated nomogram integrates clinical parameters radscore gtv ptv initial investigation revealed 339 olm positivity rate ct1 2n0m0 sclc patients combined model incorporates three radiomic features gtv ptv along two clinical parameters smoking status shape exhibited robust predictive capabilities peak auc value 0772 external validation cohort model outperformed alternative models nomogram significantly enhanced diagnostic precision radiologists added substantial value clinical decisionmaking process ct1 2n0m0 sclc patients incidence olm sclc patients surpassed nonsmall cell lung cancer patients combined model demonstrated notable generalization effect effectively distinguishing positive negative olms noninvasive manner thereby guiding individualized clinical decisions patients ct1 2n0m0 sclc