Sun Bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee
Stacked neural network for predicting polygenic risk score
Scientific reports
existing literature provide accurate epidemiological data regarding true prevalence men nonobstructive azoospermia noa would eligible hormonal optimization therapy according specific pretreatment criteria investigate characteristics men noa would qualify medical therapy prior sr procedure large multicentric crosssectional study complete data 1644 noa patients seeking medical help primary infertility three tertiary referral centers usa brazil italy analyzed baseline serum hormone levels collected patients noa confirmed two consecutive semen analyses genetic tests including karyotype analysis microdeletions performed patients patients secondary hypogonadism total testosterone levels less 300 ngdl luteinizing hormone lh levels less 8 miuml earmarked potential candidates receiving clomiphene citrate cc andor human chorionic gonadotropin hcg patients 17estradiol e2 ratio 10 classified eligible aromatase inhibitors ais therapy eg anastrazole third subcohort created combining criteria first two subcohorts descriptive statistics used detail overall characteristics differences different subcohorts among 1644 men 28 n 460 300 ngdl lh 8 miuml thereby potentially suitable cc andor hcg 37 n 607 e2 ratio 10 thus potentially suitable ais lastly 177 n 280 met criteria potential eligibility cc andor hcg ais findings multicentric crosssectional study reveal 30 men noa eligible hormonal treatment cc andor hcg 37 found potential candidates ais 17 therapies therefore findings show small subset noa patients benefit medical therapy prior considering sr procedures