May A. Beydoun|Hind A. Beydoun|Melissa Kitner?Triolo|Jay S. Kaufman|Michele K. Evans|Alan B. Zonderman
Thyroid Hormones Are Associated With Cognitive Function: Moderation by Sex, Race, and Depressive Symptoms
National Institute on Aging|National Institutes of Health|Eastern Virginia Medical School|National Institute on Aging|National Institutes of Health|McGill University|National Institute on Aging|National Institutes of Health|National Institute on Aging|National Institutes of Health
recent evidence indicates thyroid hormones may closely linked cognition among adults investigated associations thyroid hormones cognitive performance testing effect modification sex race elevated depressive symptoms eds crosssectional study used extensive data healthy aging neighborhoods diversity across life span handls study study conducted baltimore maryland 2004 2009 participants us adults aged 30 64 years sample size ranged 1275 1346 outcomes included 13 cognitive test scores spanning domains learningmemory languageverbal attention visuospatialvisuoconstruction psychomotor speed executive function mental status within reference ranges bonferroni correction elevated free thyroxine ft4 associated better performance tests visuospatialvisuoconstruction ability overall women african americans learningmemory women african americans whereas higher total thyroxine tt4 level associated better performance domain psychomotor speed individuals without eds higher levels ft4 tt4 linked better languageverbal test performance among men contrast higher t3 uptake related better performance tests visuospatialvisuoconstruction ability psychomotor speed among whites reference range compared within overall population bonferroni correction within reference range ft4 linked better performance visuospatialvisuoconstrution ability psychomotor speed whereas normal range tsh level compared reference range linked better performance domains psychomotor speed attention thyroid hormones cognition closely linked differentially sex race eds status