Saurabh Mehta|Edward Giovannucci|Ferdinand Mugusi|Donna Spiegelman|Said Aboud|Ellen Hertzmark|Gernard Msamanga|David J. Hunter|Wafaie Fawzi
Vitamin D Status of HIV-Infected Women and Its Association with HIV Disease Progression, Anemia, and Mortality
Harvard University|Brigham and Women's Hospital|Harvard University|Muhimbili University of Health and Allied Sciences|Harvard University|Muhimbili University of Health and Allied Sciences|Harvard University|Muhimbili University of Health and Allied Sciences|Brigham and Women's Hospital|Harvard University|Harvard University|Harvard Global Health Institute
background vitamin potential role slowing hiv disease progression preventing mortality based extensive involvement immune system however relationship examined large studies resourcelimited settings methodologyprincipal findings vitamin levels assessed 884 hivinfected pregnant women enrollment trial multivitamin supplementation including vitamin tanzania women followed median 695 months information hemoglobin levels hiv disease progression mortality recorded proportional hazard models generalized estimating equations used assess relationship outcomes vitamin status conclusionssignificance low vitamin status serum 25hydroxyvitamin d32ngml significantly associated progression hiv disease stage iii greater multivariate models incidence rate ratio rr 125 95 confidence intervals ci 105 150 significant relationship observed vitamin status tcell counts followup women low vitamin status 46 higher risk developing severe anemia followup compared women adequate vitamin levels rr 146 95 ci 109 196 women highest vitamin quintile 42 lower risk allcause mortality compared lowest quintile rr 058 95 ci 040 084 vitamin status protective association hiv disease progression allcause mortality development anemia followup hivinfected women confirmed randomized trials vitamin supplementation could represent simple inexpensive method prolonging time initiation antiretroviral therapy hivinfected patients particularly resourcelimited settings