Xiaoyi Zhang, Qixuan Liu, Xinyao Bai
Improved slime mould algorithm based on hybrid strategy optimization of Cauchy mutation and simulated annealing
PloS one
low immunity birth increases risk disease young livestock goat kids microbiomes change animals mature healthy microbiome related decreased risk disease relationship microbiota profiles immunity different developmental stages remains unclear young female n 12 30 adult female n 12 2 yrs old saanen dairy goats used investigate changes rumen microbiomes fecal microbiomes correlations circulating immune factors serum igg p 002 igm p 001 higher 2 years 30 age differences iga p 034 il2 p 005 il4 p 037 il6 p 073 ages amplicon sequencing analysis revealed young goats higher diversity bacterial communities rumen lower diversity feces compared adult goats ten genera rumen 14 genera feces positively correlated serum igm concentration across ages olsenella methanosphaera quinella candidatussaccharimonas methanobrevibacter rumen ruminobacter treponema rikenelaceae rc9 gut group feces positively correlated concentration igg correlation analysis using weighted gene coexpression network analysis showed meblue module positively associated igg igm data provide novel insight association rumenfeces microbiota immune response experiments needed investigate whether inoculating young livestock immunerelated bacteria identified improve immune status data suggest possible strategy improve immunity kids alterative microbiota profiles