Nasiq Hasan, Kunaal Mehrotra, Carl J Danzig, David A Eichenbaum, Amy Ewald, Carl Regillo, Bita Momenaei, Veeral S Sheth, David R Lally, Jay Chhablani
Screen failures in clinical trials in retina
Ophthalmology. Retina
corticosteroids 2adrenergic agonists commonly used pregnancy treat asthma however offspring neurodevelopmental outcomes following utero exposure medications remain unclear investigate association timing utero exposure corticosteroids 2adrenergic agonists offspring neurodevelopmental milestones first 3 years life cohort study obtained data japan environment childrens study ongoing birth cohort study conducted collaboration 15 regional centers across japan participants motheroffspring pairs recruited january 1 2011 march 31 2014 data analyzed january february 2023 corticosteroids 2adrenergic agonists exposure interest timing corticosteroid 2adrenergic agonist exposure included early pregnancy weeks 012 mid late pregnancy weeks 12 stages pregnancy offspring neurodevelopmental milestones communication gross motor fine motor problemsolving personalsocial skills assessed using japanese version ages stages questionnaires 3rd edition 6 12 18 24 30 36 months total 91 460 motheroffspring pairs analyzed among mothers mean sd age delivery 3120 505 years among offspring 46 596 509 males 44 864 491 females 664 gestational age 39 41 weeks early mid late stages pregnancy 401 04 935 10 568 06 offspring respectively exposed corticosteroids whereas 170 02 394 04 184 02 respectively exposed 2adrenergic agonists association corticosteroid exposure early mid late stages pregnancy 5 neurodevelopmental milestones found similarly association 2adrenergic agonist use early pregnancy 5 neurodevelopmental milestones observed association found 2adrenergic agonist exposure mid late pregnancy delayed personalsocial skills adjusted odds ratio 148 95 ci 101232 p 045 results study found association utero corticosteroid 2adrenergic agonist exposure offspring neurodevelopmental outcomes regardless timing exposure despite limitations low power study findings suggest corticosteroids 2adrenergic agonists safe pregnant individuals asthma neurodevelopment offspring