Lei Yu|Robert S. Wilson|S. Duke Han|Sue E. Leurgans|David A. Bennett|Patricia A. Boyle
Decline in Literacy and Incident AD Dementia Among Community-Dwelling Older Persons
Rush University Medical Center|Rush University Medical Center|Rush University Medical Center|University of Southern California|Rush University Medical Center|Rush University Medical Center|Rush University Medical Center
objective quantify longitudinal change financial health literacy examine associations declining literacy incident alzheimers disease ad dementia mild cognitive impairment mci method data came 799 participants ongoing cohort study literacy measured using battery 32 questions clinical diagnoses made annually following uniform structured procedures associations declining literacy incident ad dementia mci tested using joint model longitudinal timetoevent data results observed overall decline total literacy score 6 years followup p lt 001 faster decline literacy associated higher risks incident ad dementia hazard ratio 4526 95 confidence interval 2993 6843 p lt 001 incident mci hazard ratio 2971 95 confidence interval 1509 5849 p 002 discussion declining literacy among communitydwelling older persons predicts adverse cognitive outcomes serves early indicator impending dementia