L Carlos Gutierrez, Candace Ayars
Analyzing the training of PAs in ophthalmology
JAAPA : official journal of the American Academy of Physician Assistants
mucociliary clearance plays critical role pulmonary host defense abnormal mucociliary clearance contributes pathogenesis pulmonary disorders including copd bronchiectasis treatments targeting mucus obstruction airways include use high frequency chest wall oscillation hfcwo therapy prospective outcome based study designed investigate changes symptoms quality life qol measure effect adjunctive hfcwo therapy standard care therapy patients copd hfcwo indicated used intended quality life patients copd improve sustain improvement conducted prospective openllabel observational study copd patients without concomitant bronchiectasis participants assessments qol baseline day 0 30 90 days initiation hfcwo therapy st georges respiratory questionnaire copd patients sgrqc employed longitudinally followed timepoint paired ttests used compare means time points adjusted multiple comparisons linear mixed model analysis longitudinal data constructed determine simultaneous contribution race gender ethnicity time selected interactions primary outcome change sgrqc across 0 30 90 days cohort patients n102 demonstrated significant reduction sgrqc 30 sustained 90 days compared baseline addition two component scores sgrqc questionnaire symptoms impacts significantly reduced 30 90 days prospective observational study demonstrates statistically significant clinically favorable responses hfcwo adjunctive therapy patients primary diagnosis copd without concomitant bronchiectasis results study inform design additional additional studies hfcwo prove efficacy incopd patients