Holly Hope|George Michael Binkley|Sally A. M. Fenton|George D. Kitas|Suzanne Verstappen|D. Symmons
Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease
Versus Arthritis|University of Manchester|Versus Arthritis|University of Manchester|University of Birmingham|University of Birmingham|Dudley Group NHS Foundation Trust|Russells Hall Hospital|Versus Arthritis|University of Manchester|NIHR Manchester Biomedical Research Centre|Manchester University|Versus Arthritis|University of Manchester
introduction previous research shown statin adherence primary prevention cvd lower compared secondary prevention populations therefore aim systematic review review predictors statin adherence primary prevention cvd methods systematic search papers published jan 1984 may 2017 conducted pubmed psycinfo embase cinahl databases study eligible inclusion 1 study general population patients familial hypercholesterolemia hypertension diabetes arthritis 2 statins prescribed 3 adherence defined measured extent patients followed statin regimen period prescription 4 original trial observational study excluding case reports study subsequently excluded 1 results presented separately primary prevention 2 trial intervention example patient education papers reviewed two researchers consensus agreed third quality assessment qa tool used formally assess included article evaluate effect predictors data quantitatively qualitatively synthesised results total 19 studies met inclusion criteria nine evaluated high quality using qa tool proportion patients classed adherent ranged 178 792 potential predictors statin adherence included traditional risk factors cvd age male diabetes hypertension income associated adherence strongly men women highly educated men likely highly educated women less likely adherent alcohol misuse high bmi associated nonadherence association polypharmacy statin adherence evidence base effect lifestyle factors health beliefs statin adherence limited conclusion current evidence suggests patients traditional risk factors cvd likely adherent statins implications future research discussed