Christine P. Stewart|Parul Christian|Kerry Schulze|Steven C. LeClerq|Keith P. West|Subarna K. Khatry
Antenatal Micronutrient Supplementation Reduces Metabolic Syndrome in 6- to 8-Year-Old Children in Rural Nepal ,
Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Nepal Red Cross Society|Johns Hopkins University|Nepal Red Cross Society
previously showed antenatal micronutrient supplementation increases birth weight malnourished rural south asian setting longterm effects unknown 1999 2001 pregnant women sectorrandomized receive early pregnancy 3 mo postpartum daily micronutrient supplements containing either vitamin alone control folic acid folic acidiron folic acidironzinc multiple micronutrient supplement included nutrients plus 11 others 2006 2008 3524 children 93 surviving children revisited ages 6 8 blood pressure bmi waist circumference glycated hemoglobin cholesterol triglycerides glucose insulin urinary microalbumincreatinine ratio assessed among children insulin resistance estimated using homeostasis model assessment homa metabolic syndrome defined using modified national cholesterol education program definition none micronutrient supplement combinations affected blood pressure cholesterol triglycerides glucose insulin homa reduced risk microalbuminuria 340 mgmmol creatinine folic acid odds ratio 056 95ci 033093 p 002 folic acidironzinc 053 ci 032089 p 002 groups reduced risk metabolic syndrome folic acid group 063 ci 041097 p 003 maternal supplementation folic acid folic acidironzinc reduced risk kidney dysfunction extent metabolic syndrome among children 68 age supplementation multiple micronutrients affect future followup studies needed examine longterm supplementation effects risk chronic diseases adults