Xin Zhang, Shanzhen Gao, Yanyan Cheng, Fanbo Meng
Encouraging physicians' continuous knowledge-sharing in online health communities: A motivational perspective
Frontiers in public health
association periodontitis pd parkinsons disease pk discussed due inflammatory component neurodegenerative processes pk severity affected areas determined using following neuropsychological tests unified parkinsons disease rating score updrs hoehn yahr nonmotoric symptoms nonmotor symptoms scale nmss cognitive involvement minimental state examination mmse neuroinflammation resulting glucose6phosphatasedehydrogenase g6pd dysfunction part pathophysiology pk study aimed evaluate associations periodontal inflammation clinical data saliva serum rnabiobank samples 50 wellcharacterized diametric patients pk five age sexmatched neurologically healthy participants analyzed g6pd function periodontal pathogens aggregatibacter actinomycetemcomitans porphyromonas gingivalis tannerella forsythia treponema denticola prevotella intermedia campylobacter rectus fusobacterium nucleatum filifactor alocis monocyte chemoattractant protein mcp 1 interleukin il 1beta regression analysis used identify associations clinical behavioral data ttests used compare health disease compared pk pathogens lower inflammatory markers p 0001 detectible healthy saliva serum pkseverityupdrs interrelated occurrence prevotella intermedia serum well il1beta levels serum saliva p 0006 0019 0034 hoehn yahr correlated porphyromonas gingivalis prevotella intermedia rna il1beta regulation serum saliva il1beta levels pvalues 0038 0011 0008 0001 0010 mmse associated aggregatibacter actinomycetemcomitans fusobacterium nucleatum serum mcp 1 levels rna il1beta regulation g6pd serum activity p 0036 0003 0045 0001 0021 cognitive motor skills seem important representative tests associated periodontal pathogens oralgeneral inflammation wherein g6pdsaliva dysfunction might involved httpswwwbfarmdededasbfarmaufgabendeutschesregisterklinischerstudiennodehtml identifier drks00005388