Mingjian He, Proloy Das, Gladia Hotan, Patrick L Purdon
Switching state-space modeling of neural signal dynamics
PLoS computational biology
long covid patientcoined term persistent symptoms covid19 illness weeks months years following acute infection large burden long covid globally selfreported data epidemiology causes treatments remain poorly understood primary care used help identify treat patients long covid therefore electronic health records ehrs past covid19 patients could used help fill knowledge gaps aimed describe incidence differences demographic clinical characteristics recorded long covid primary care records england approval nhs england used routine clinical data 19 million adults england linked sarscov2 test result hospitalisation vaccination data describe trends recording 16 clinical codes related long covid november 2020 january 2023 using opensafely calculated rates per 100000 personyears plotted changed time compared crude adjusted age sex 9 nhs regions england dominant variant circulating rates recorded long covid patient records different key demographic vaccination characteristics using negative binomial models identified total 55465 people recorded long covid study period included 20025 diagnoses codes 35440 codes assessment incidence new long covid records increased steadily 2021 declined 2022 overall rate per 100000 personyears 1775 cases women 95 ci 1755179 1005 men 995102 majority long covid record recorded positive sarscov2 test 12 weeks long covid record descriptive study ehr recorded long covid low 2020 2023 incident records long covid declined 2022 using ehr diagnostic referral codes unfortunately major limitations identifying ascertaining true cases timing long covid research supported national institute health care research nihr openprompt covlt20073