Elliot Murphy
ROSE: A Neurocomputational Architecture for Syntax
ArXiv
polycystic ovary syndrome pcos common among females significant metabolic reproductive comorbidities describe pcos development pediatric population assessed cardiometabolic biomarkers adiposity midchildhood mean 79 early teen mean 131 midteen mean 178 visits among 417 females prospective project viva cohort defined pcos via selfreported diagnosis ovulatory dysfunction hyperandrogenism midlate adolescence used multivariable logistic regression assess associations metabolic adiposity markers visit pcos adolescents pcos n 56 13 versus without higher mean sd bmi zscore truncal fat mass midchildhood 066 099 vs 030 104 35 kg 26 vs 27 15 early teen 088 101 vs 025 108 94 kg 67 vs 61 34 midteen 078 103 vs 033 097 116 kg 72 vs 91 49 visits well lower adiponectin leptin ratio early 065 069 vs 104 097 midteen 033 026 vs 075 121 visits models adjusted maternal pcos education child race ethnicity social factors found higher odds pcos per 1sd increase truncal fat midchildhood odds ratio 142 95 confidence interval ci 103195 early teen visits 161 95 ci 114228 lower odds per 1sd increase adiponectinleptin ratio midteen visit 014 95 ci 003058 childhood excess adiposity adipose tissue dysfunction may first signs later pcos risk