Zehra Gok Metin, Ali Naci Yildiz
Update on occupational health nursing through 21st century requirements: A three-round Delphi study
Nurse education today
association antibiotic use pregnancy neonatal birth outcomes received considerable attention previous assessment antibiotic exposure pregnancy relied questionnaires clinical prescriptions studies examined pregnancy exposure antibiotics using human biomonitoring data explore association cumulative exposure antibiotics whole pregnancy neonatal birth measurements using biomonitoring data antibiotics meconium three hundred sixty nine pregnant women within maternal psychological environmental assessments kids cohort study randomly selected study eighteen common antibiotics six categories six lactams three tetracyclines four sulfonamides one phenicols one lincosamides three fluoroquinolones selected target antibiotics meconium measurement conducted ultraperformance liquid chromatography coupled quadrupole timeofflight mass spectrometry platform neonatal birth measurements obtained medical records multiple linear regression models used examine associations antibiotic exposure neonatal birth outcome birth weight birth length placental growth indicators placental surface area placental weight logistic regressions used evaluate associations small gestational age sga large gestational age lga twelve eighteen antibiotics found 621 meconium detection rates ranging 03 439 three antibiotics highest detection rates chlortetracycline 439 penicillin 165 chloramphenicol 108 respectively highest antibiotic concentration among detected antibiotics penicillin 2424315 gkg concentration penicillin positively associated birth weight 0025 95 cis 00030047 significant positive association also observed concentration chlortetracycline placental surface area 2559 95 cis 02964822 associations sex related mainly observed female newborns exposure penicillin also found associated increased risk lga consistent changes birth weight pregnancy exposure certain antibiotics associated altered fetal growth development may affect normal growth trajectory infants children later life