Ryan G. Vandrey|Maxine L. Stitzer|Miriam Z. Mintzer|Marilyn A. Huestis|Jeannie Murray|Dayong Lee
The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users
Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|National Institute on Drug Abuse|Johns Hopkins Medicine|Johns Hopkins University|National Institute on Drug Abuse
prior studies separately examined effects dronabinol oral thc cannabis withdrawal cognitive performance acute effects smoked cannabis single study examining clinically relevant domains would benefit continued evaluation dronabinol potential medication treatment cannabis use disorders thirteen daily cannabis smokers completed withinsubject crossover study received 0 30 60 120 mg dronabinol per day 5 consecutive days vital signs subjective ratings cannabis withdrawal craving sleep obtained daily outcomes active dose conditions compared obtained placebo dosing 5th day medication maintenance participants completed comprehensive cognitive performance battery smoked five puffs cannabis subjective effects evaluation dronabinol maintenance period occurred counterbalanced order separated 9 days ad libitum cannabis use dronabinol dosedependently attenuated cannabis withdrawal resulted adverse side effects decrements cognitive performance surprisingly dronabinol alter subjective effects smoked cannabis cannabisinduced increases heart rate attenuated 60 120 mg doses dronabinols ability dosedependently suppress cannabis withdrawal may therapeutically beneficial individuals trying stop cannabis use absence gross cognitive impairment side effects study supports safety doses 120 mgday continued evaluation dronabinol targeted clinical studies cannabis treatment using expanded range doses warranted