Jennifer Weuve|Cécile Proust?Lima|Melinda C. Power|Alden L. Gross|Scott M. Hofer|Rodolphe Thiébaut|Geneviève Chêne|M. Maria Glymour|Carole Dufouil
Guidelines for reporting methodological challenges and evaluating potential bias in dementia research
Rush University Medical Center|Bordeaux Population Health|Inserm|Johns Hopkins University|Johns Hopkins University|University of Victoria|Bordeaux Population Health|Inserm|Bordeaux Population Health|Inserm|University of California, San Francisco|Harvard University|Bordeaux Population Health|Inserm
clinical population research dementia related neurologic conditions including alzheimers disease faces several unique methodological challenges progress identify preventive therapeutic strategies rests valid rigorous analytic approaches research literature reflects little consensus best practices present findings large scientific working group research methods clinical population studies dementia identified five categories methodological challenges follows 1 attritionsample selection including selective survival 2 measurement including uncertainty diagnostic criteria measurement error neuropsychological assessments practice retest effects 3 specification longitudinal models participants followed months years even decades 4 timevarying measurements 5 highdimensional data explain challenge important dementia research could compromise translation research findings effective prevention care strategies advance checklist potential sources bias routinely addressed reporting dementia research