Jiahui Qian, Stephanie Zeritis, Mark Larsen, Michelle Torok
The application of spatial analysis to understanding the association between area-level socio-economic factors and suicide: a systematic review
Social psychiatry and psychiatric epidemiology
ad prevalent cause dementia affects twice many women men therapeutic options limited results prior studies support hypothesis estrogen treatment may improve symptoms women disorderfortytwo women mildtomoderate dementia due ad enrolled randomized doubleblind placebocontrolled parallelgroup trial unopposed conjugated equine estrogens 125 mgday 16 weeksoutcome data available 40 women 4 weeks 36 women 16 weeks 4 16 weeks significant differences statistical trends treatment groups primary outcome measure cognitive subscale alzheimers disease assessment scale clinicianrated global impression change caregiverrated functional status exploratory analyses mood specific aspects cognitive performance also failed demonstrate substantial group differencesalthough conclusions limited small sample size possibility type ii error results suggest shortterm estrogen therapy improve symptoms women ad findings address possible longterm effects estrogen ad possible interactions estrogen treatment modalities putative effects estrogen preventing delaying onset disorder