Susanne R Gaal, Matthew B Fuller
School Safety and Mental Health Awareness: Recommendations from K-12 Texas Public School Teachers
The Journal of school health
diverse b cell repertoires play important role mounting effective immune responses wide range pathogens malignant cells number unique b cell clones characterized b cell receptors tcrs bcrs respectively although receptor sequences generated probabilistically recombination processes clinical studies found high degree sharing tcrs bcrs among different individuals work use general probabilistic model tb cell receptor clone abundances define publicness privateness informationtheoretic measures comparing frequency sampled sequences observed across different individuals derive mathematical formulae quantify mean variances clone richness overlap results used evaluate effect different sampling protocols abundances clones within individual well commonality clones across individuals using synthetic empirical tcr amino acid sequence data perform simulations study expected clonal commonalities across multiple individuals based formulae compare simulated results analytically predicted mean variances repertoire overlap complementing results simulated repertoires derive explicit expressions richness uncertainty specific singleparameter truncated powerlaw probability distributions finally information loss associated grouping together certain receptor sequences done spectratyping also evaluated approach principle applied general mechanistically realistic clone generation models