Manickam Ponnaiah, Tarun Bhatnagar, Parasuraman Ganeshkumar, Ditipriya Bhar, Rajalakshmi Elumalai, Mathavaswami Vijayageetha, Rizwan Suliankatchi Abdulkader, Sirshendu Chaudhuri, Upasana Sharma, Manoj Vasant Murhekar
"Design and implementation challenges of massive open online course on research methods for Indian medical postgraduates and teachers -descriptive analysis of inaugural cycle"
BMC medical education
oxidative stress implicated pathogenesis diverse disease states may common pathogenic mechanism underlying many major psychiatric disorders brain comparatively greater vulnerability oxidative damage review aims examine current evidence role oxidative stress psychiatric disorders academic clinical implications literature search conducted using medline pubmed psycinfo cinahl plus biosis preview cochrane databases timeframe extending september 2007 broadest data oxidative stress mechanisms derived studies conducted schizophrenia evidence available different areas oxidative research including oxidative marker assays psychopharmacology studies clinical trials antioxidants bipolar disorder depression solid foundation oxidative stress hypotheses provided biochemical genetic pharmacological preclinical therapeutic studies one clinical trial oxidative pathophysiology anxiety disorders strongly supported animal models also human biochemical data pilot studies suggested efficacy nacetylcysteine cocaine dependence early evidence accumulating oxidative mechanisms autism attention deficit hyperactivity disorder conclusion multidimensional data support role oxidative stress diverse psychiatric disorders data suggest oxidative mechanisms may form unifying common pathogenic pathways psychiatric disorders also introduce new targets development therapeutic interventions