Seong-Uk Baek, Jin-Ha Yoon
Depressive Symptomatology as a Predictor of Cognitive Impairment: Evidence from the Korean Longitudinal Study of Aging (KLOSA), 2006-2020
Biomedicines
drugresistant tuberculosis tb major threat global public health wholegenome sequencing wgs useful tool species identification drug resistance prediction many clinical laboratories transitioning wgs routine diagnostic tool however userfriendly highconfidence automated bioinformatics tools needed rapidly identify tuberculosis complex mtbc nontuberculous mycobacteria ntm detect drug resistance guide treatment options developed genomycanalyzer webbased software integrates functions identifying mtbc ntm species lineage spoligotype prediction variant calling annotation drugresistance determination data visualization accuracy genomycanalyzer genotypic drug susceptibility testing gdst evaluated using 5473 mtbc isolates underwent phenotypic dst pdst genomycanalyzer database built predict gdst 15 antituberculosis drugs using world health organization mutational catalogue compared pdst sensitivity drug susceptibilities genomycanalyzer firstline drugs ranged 959 rifampicin 95 ci 948967 796 pyrazinamide 95 ci 769822 whereas secondline drugs ranged 982 levofloxacin 95 ci 9011000 749 capreomycin 95 ci 693800 notably integration large deletions four resistanceconferring genes increased gdst sensitivity specificity drug susceptibilities genomycanalyzer ranged 987 amikacin 95 ci 978993 795 ethionamide 95 ci 764823 incorporated kraken2 software identified 1284 mycobacterial species accuracy 988 genomycanalyzer also perfectly predicted lineages 1935 mtbc spoligotypes 54 mtbc genomycanalyzer offers webbased graphical user interfaces help biologists limited access highperformance computing systems limited bioinformatics skills streamlining interpretation wgs data genomycanalyzer potential significantly impact tb management contribute global efforts combat infectious disease genomycanalyzer available httpwwwmycochaseorg