Heather Mangino
The experiences of undergraduate nursing students with mental health conditions in the inpatient clinical setting: A qualitative study
Nurse education today
metastasis recurrence main causes death postoperative bladder cancer bc emphasizing importance exploring earlystage diagnostic markers serum biomarkers constitute promising diagnostic approach asymptomatic stage cancer noninvasive high accuracy low cost correlate concentrations plasma amino acids bc progression assess utility earlystage diagnostic newly diagnosed bc patients n 95 normal controls n 96 recruited period 1 december 2018 30 december 2020 general food frequency questionnaires established basic information dietary intake data venous blood samples collected fasting subjects used detect levels plasma amino acids liquid chromatographymass spectrometry verification performed gse13507 transcriptome gene expression matrix bc gene expression omnibus geo database eleven amino acids identified altered plasma newly diagnosed bc patients compared controls p 005 adjusted gender education smoking factors plasma ornithine level 0256 95 ci 01040630 protective factor bc plasma levels methionine 3460 95 ci 13848651 arginine 3851 95 ci 15429616 glutamate 3813 95 ci 15439419 risk factors bc roc analysis demonstrated combination plasma ornithine methionine arginine glutamate could accurately diagnose bc auc 084 95 ci 07470833 addition mrna level arginase 1 decreased p 005 inducible nitric oxide synthase increased significantly may linked disturbance arginine metabolism bc patients analysis geo database confirmed role arginine metabolism biomarker panel containing four amino acids may provide feasible strategy early diagnosis bc however validation required prospective studies