Deborah A. Levine|Alden L. Gross|Emily M. Briceño|Nicholas Tilton|Bruno Giordani|Jeremy B. Sussman|Rodney A. Hayward|James F. Burke|Stephanie Hingtgen|Mitchell S.V. Elkind|Jennifer J. Manly|Rebecca F. Gottesman|Darrell J. Gaskin|Stephen Sidney|Ralph L. Sacco|Sarah E. Tom|Clinton B. Wright|Kristine Yaffe|Andrzej T. Ga?ecki
Sex Differences in Cognitive Decline Among US Adults
University of Michigan–Ann Arbor|Johns Hopkins University|University of Michigan–Ann Arbor|University of Michigan–Ann Arbor|University of Michigan–Ann Arbor|University of Michigan–Ann Arbor|VA Ann Arbor Healthcare System|University of Michigan–Ann Arbor|VA Ann Arbor Healthcare System|University of Michigan–Ann Arbor|VA Ann Arbor Healthcare System|University of Michigan–Ann Arbor|Columbia University|Columbia University|Johns Hopkins University|Johns Hopkins University|Kaiser Permanente|University of Miami|Columbia University|National Institute of Neurological Disorders and Stroke|University of California, San Francisco|University of Michigan–Ann Arbor
sex differences dementia risk unclear studies found greater risk womento determine associations sex cognitive decline order better understand sex differences dementia riskthis cohort study used pooled analysis individual participant data 5 cohort studies years 1971 2017 atherosclerosis risk communities study coronary artery risk development young adults study cardiovascular health study framingham offspring study northern manhattan study linear mixedeffects models used estimate changes continuous cognitive outcome time sex data analysis completed march 2019 october 2020sexthe primary outcome change global cognition secondary outcomes change memory executive function outcomes standardized scores mean sd 50 10 1point difference represents 01sd difference cognitionamong 34 349 participants 26 088 selfreported black white race free stroke dementia covariate data first cognitive assessment included analysis median interquartile range followup 79 53205 years 11 775 447 men median interquartile range age 58 5166 years first cognitive assessment 2229 189 black 14 313 women median interquartile range age 58 5167 years first cognitive assessment 3636 254 black women significantly higher baseline performance men global cognition 220 points higher 95 ci 204 235 points p 001 executive function 213 points higher 95 ci 198 229 points p 001 memory 189 points higher 95 ci 172 206 points p 001 compared men women significantly faster declines global cognition 007 pointsy faster 95 ci 008 005 pointsy p 001 executive function 006 pointsy faster 95 ci 007 005 pointsy p 001 men women similar declines memory 0004 pointsy faster 95 ci 0023 0014 p 61the results cohort study suggest women may greater cognitive reserve faster cognitive decline men could contribute sex differences latelife dementia