Philip W. Davidson|JJ Strain|Gary J. Myers|Sally W. Thurston|Maxine P. Bonham|Conrad F. Shamlaye|Abbie Stokes?Riner|J. M. W. Wallace|Paula J. Robson|Emeir M. Duffy|Lesley Georger|Jean Sloane-Reeves|Elsa Cernichiari|Richard L. Canfield|Christopher Cox|Li?Shan Huang|Joanne Janciuras|Thomas W. Clarkson
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
University of Rochester|University of Ulster|University of Rochester|University of Rochester|University of Ulster|University of Seychelles|University of Rochester|University of Ulster|University of Ulster|University of Ulster|University of Rochester|University of Rochester|University of Rochester|Cornell University|Johns Hopkins University|University of Rochester|University of Rochester|University of Rochester
fish contain nutrients promote optimal brain growth development also contain methylmercury mehg toxic effects present study tested hypothesis intake selected nutrients fish measures maternal nutritional status may represent important confounders estimating effects prenatal methylmercury exposure child development study took place republic seychelles indian ocean archipelago fish consumption high longitudinal cohort study design used total 300 mothers enrolled early pregnancy nutrients considered important brain development measured pregnancy along prenatal mehg exposure children evaluated periodically age 30 months 229 children complete outcome covariate data analysis primary endpoint bayley scales infant developmentii bsidii administered 9 30 months age combinations four secondary measures infant cognition memory also given 5 9 25 months cohort mothers consumed average 537 g fish nine meals containing fish per week average prenatal mehg exposure 59 ppm maternal hair primary analysis examined associations mehg maternal nutritional measures childrens scores bsidii showed adverse association mehg mean psychomotor developmental index pdi score 30 months secondary analyses association pdi mehg alone nutritional factors alone showed borderline significant association mehg pdi 30 months associations nutritional factors one experimental measure 5 months age positively associated iodine status prenatal mehg exposure findings suggest possible confounding role maternal nutrition studies examining associations prenatal mehg exposures developmental outcomes children