Jaclyn Abraham|Grace Wei|Seemal R. Desai|Lucia Seminario?Vidal
A cross-sectional analysis of quality of life in skin of color patients with cutaneous T-cell lymphoma: An exploratory study
University of South Florida|University of South Florida|The University of Texas Southwestern Medical Center|Plano Cancer Institute|Moffitt Cancer Center
editor recent research acknowledges differences outcomes skin color soc nonskin color nsoc patients diagnosed cutaneous tcell lymphoma ctcl1geller lebowitz e pulitzer mp et aloutcomes prognostic factors african american black patients mycosis fungoidesszary syndrome retrospective analysis 157 patients referral cancer centerj acad dermatol 2020 83 430439abstract full text full text pdf pubmed scopus 25 google scholar ctcl patients also often experience poorer healthrelated quality life hrqol2ottevanger r van beugen evers awm willemze r vermeer mh quint kd quality life patients mycosis fungoides szary syndrome systematic review literaturej eur acad dermatol venereol 2021 35 23772387crossref pubmed scopus 11 google scholar however little known impact ctcl hrqol disparities affecting soc populations exploratory study sought address gap describing observations reported functional physical social psychological qol factors among surveyed ctcl patients established adult patients diagnosed ctcl per national comprehensive cancer network guidelines presenting clinic visit moffitt cancer center invited participate anonymous electronic survey may 1 june 17 2021 survey questions compiled 3 validated hrqol inventories descriptive analyses performed categorical participant attributes compared 2 fishers exact test p 05 statistical analyses performed using spss version 26 total 84 patients ctcl 2526 soc 5968 nsoc completed survey 88 response rate median age soc patients 545 years interquartile range 2881 years nsoc patients 67 interquartile range 1894 years soc patients reported greater impact ctcl socialleisure activities 20 vs 51 difficulty participating sports 20 vs 88 larger proportion soc patients reported higher degrees itch 40 vs 186 skinrelated embarrassment selfconsciousness 28 vs 103 soc patients also reported feeling uncomfortable diagnosis 60 vs 345 supplementary table available via mendeley httpsdatamendeleycomdatasets98jjsbybzy1 summarizes key findings supplementary table ii available via mendeley httpsdatamendeleycomdatasets98jjsbybzy1 describes results fig 1 presents graphical survey results observations exploratory survey suggest impact ctcl hrqol substantial certain aspects hrqol affected among soc patients data support prior research demonstrating decreased qol domains among ctcl community soc communities cutaneous disease2ottevanger r van beugen evers awm willemze r vermeer mh quint kd quality life patients mycosis fungoides szary syndrome systematic review literaturej eur acad dermatol venereol 2021 35 23772387crossref pubmed scopus 11 google scholar 3holahan hm farah rs fitz et alhealthrelated quality life patients cutaneous tcell lymphomaint j dermatol 2018 57 13141319crossref pubmed scopus 15 google scholar 4alexis af blackcloud p psoriasis skin color epidemiology genetics clinical presentation treatment nuancesj clin aesthet dermatol 2014 7 1624pubmed google scholar 5shaw fm luk kmh chen kh wrenn g chen sc racial disparities impact chronic pruritus crosssectional study quality life resource utilization united states veteransj acad dermatol 2017 77 6369abstract full text full text pdf pubmed scopus 22 google scholar example soc patients psoriasis similarly experience greater hrqol disparities4alexis af blackcloud p psoriasis skin color epidemiology genetics clinical presentation treatment nuancesj clin aesthet dermatol 2014 7 1624pubmed google scholar broadly across dermatologic spectrum pruritus general also reported greater severity emotional distress among soc communities5shaw fm luk kmh chen kh wrenn g chen sc racial disparities impact chronic pruritus crosssectional study quality life resource utilization united states veteransj acad dermatol 2017 77 6369abstract full text full text pdf pubmed scopus 22 google scholar indeed evaluating impact ctcl psychological hrqol soc patients selfconscious uncomfortable beforetoafter diagnosis possible factors underlying observed differences include visible dyspigmentation cultural perceptions cutaneous disease health care access resource utilization4alexis af blackcloud p psoriasis skin color epidemiology genetics clinical presentation treatment nuancesj clin aesthet dermatol 2014 7 1624pubmed google scholar5shaw fm luk kmh chen kh wrenn g chen sc racial disparities impact chronic pruritus crosssectional study quality life resource utilization united states veteransj acad dermatol 2017 77 6369abstract full text full text pdf pubmed scopus 22 google scholar study limitations include limited awareness reporting disease stage particularly among soc patients highlights potential practice gap research needed better understand factors underlying health literacy disparities patients surveyed diagnosis therefore responses questions related beforetoafter diagnosis subject recall bias addition median age soc patients cohort younger nsoc patients may contributed group differences however observed age distribution soc nsoc patients representative demographics disease1geller lebowitz e pulitzer mp et aloutcomes prognostic factors african american black patients mycosis fungoidesszary syndrome retrospective analysis 157 patients referral cancer centerj acad dermatol 2020 83 430439abstract full text full text pdf pubmed scopus 25 google scholar larger robust studies across multiple institutions geographic distributions needed better elucidate factors underlying qol disparities affecting soc populations ctcl essential advocacy resource development support chronic management disease dr seminariovidal served advisory boards speaker kyowa kirin inc helsinn dr seminariovidal institution received research support innate pharma sa helsinn eisai co soligenix elorac inc ctcl studies authors abraham wei desai conflicts interest declare