Jeffrey R. Kaiser|Shasha Bai|Neal Gibson|Greg J. Holland|Tsai Mei Lin|Christopher J. Swearingen|Jennifer K. Mehl|Nahed O. ElHassan
Association Between Transient Newborn Hypoglycemia and Fourth-Grade Achievement Test Proficiency
Baylor College of Medicine|University of Arkansas for Medical Sciences|University of Central Arkansas|Conway School of Landscape Design|University of Central Arkansas|Conway School of Landscape Design|Arkansas Department of Health|University of Arkansas for Medical Sciences|Samumed (United States)|Baylor College of Medicine|University of Arkansas for Medical Sciences
prolonged neonatal hypoglycemia associated poor longterm neurocognitive function however little known association early transient newborn hypoglycemia academic achievementto determine early within first 3 hours life transient hypoglycemia single initial low glucose concentration followed second value cutoff associated subsequent poor academic performancea retrospective populationbased cohort study infants born january 1 1998 december 31 1998 university arkansas medical sciences least 1 recorded glucose concentration universal newborn glucose screening policy effect conducted medical record data newborns normoglycemia transient hypoglycemia matched student achievement test scores 2008 arkansas department education anonymized logistic regression models developed evaluate association transient hypoglycemia schoolage achievement test proficiency based perinatal factors common hypoglycemia cutoffs glucose level less 35 mgdl primary less 40 45 mgdl secondary investigated 1943 normoglycemic transiently hypoglycemic infants 2342 weeks gestation eligible inclusion study infants prolonged hypoglycemia congenital anomalies chromosomal abnormalities excluded studyhypoglycemia newbornthe primary outcome proficiency fourthgrade literacy mathematics achievement tests age 10 years hypothesized priori newborns early transient hypoglycemia would less proficient fourthgrade achievement tests compared normoglycemic newbornsperinatal data matched fourthgrade achievement test scores 1395 newbornstudent pairs 718 transient hypoglycemia glucose level 35 40 45 mgdl observed 64 89 1395 103 143 1395 193 269 1395 newborns respectively controlling gestational age group race sex multifetal gestation insurance status maternal educational level socioeconomic status gravidity transient hypoglycemia associated decreased probability proficiency literacy mathematics fourthgrade achievement tests 3 hypoglycemia cutoffs adjusted odds ratios 95 cis literacy 049 028083 043 028067 062 045085 respectively adjusted odds ratios 95 cis mathematics 049 029082 051 034078 078 057108 respectivelyearly transient newborn hypoglycemia associated lower achievement test scores age 10 years given findings serious contrary expert opinion results need validated populations universal newborn glucose screening adopted