Serge P Eholie, Didier K Ekouevi, Corine Chazallon, Charlotte Charpentier, Eugène Messou, Zelica Diallo, Jacques Zoungrana, Albert Minga, Ndeye Fatou Ngom Gueye, Denise Hawerlander, Fassery Dembele, Géraldine Colin, Boris Tchounga, Sophie Karcher, Jérome Le Carrou, Annick Tchabert-Guié, Thomas-d'Aquin Toni, Abdoul-Salam Ouédraogo, Guillaume Bado, Coumba Toure Kane, Moussa Seydi, Armel Poda, Ephrem Mensah, Illah Diallo, Youssouf Joseph Drabo, Xavier Anglaret, Françoise Brun-Vezinet
Efficacy and safety of three antiretroviral therapy regimens for treatment-naive African adults living with HIV-2 (FIT-2): a pilot, phase 2, non-comparative, open-label, randomised controlled trial
The lancet. HIV
people problematic alcohol use reach treatment dropout frequent therapy problematic alcohol use delivered via video conference ealcohol therapy might overcome treatment barriers randomised study tested whether proactive ealcohol therapy outperformed facetoface alcohol therapy standard care regarding treatment initiation compliance weekly alcohol intake 3month 12month followup twoarm randomised controlled trial recruited individuals problematic alcohol use defined score 8 alcohol use disorders identification test 18 years older access personal computer smartphone tablet internet access denmark online advertisements participants assigned receive alcohol therapy delivered either facetoface via video conference number frequency duration therapy sessions individualised groups data analysis conducted using masked data primary analyses based intentiontotreat sample study registered clinicaltrialsgov nct03116282 jan 22 2018 june 29 2020 816 individuals signed trial 502 63 assessed eligibility randomly assigned 379 proactive ealcohol therapy n187 standard care n192 170 48 participants female 186 52 male intervention group participants initiated treatment 155 88 177 vs 96 54 179 odds ratio 63 95 ci 28 138 p00001 3 months 151 85 177 vs 115 64 179 32 95 ci 16 62 p00007 12 months complied treatment 130 73 177 vs 74 41 179 40 95 ci 22 72 p00001 3 months 140 79 177 vs 95 53 179 34 95 ci 18 63 p00002 12 months weekly alcohol intake significantly lower intervention group 3 months 130 standard drinks per week vs 213 standard drinks per week adjusted difference 67 95 ci 123 10 p0019 proactive ealcohol therapy associated increased treatment initiation compliance promising easily accessible effective alcohol treatment individuals problematic alcohol use trygfonden