Shiomi Kuwabara, Evan R Landers, Derek J Fisher
Impact of nutrients on the function of the chlamydial Rsb partner switching mechanism
Pathogens and disease
posthemorrhagic hydrocephalus phh remains major morbidity premature birth resulting intraventricular hemorrhage ivh national consensus guidelines timing surgical interventions lacking leads considerable variations management among neonatal intensive care units nicus early intervention ei shown improve outcomes authors hypothesized timing ivh intervention affects comorbidities complications associated phh management authors used large national inpatient care data set characterize comorbidities complications associated phh management premature infants authors used hospital discharge data 20062019 healthcare cost utilization project hcup kids inpatient database kid conduct retrospective cohort study premature pediatric patients weight 1500 g phh predictor variable timing phh intervention ei 28 days vs late intervention li 28 days hospital stay data included hospital region gestational age birth weight bw length stay los phh treatment procedures comorbidities surgical complications death statistical analysis included chisquare wilcoxon ranksum tests cox proportional hazards regression logistic regression generalized linear model poisson gamma distributions analysis adjusted demographic characteristics comorbidities death 1853 patients diagnosed phh 488 26 documented timing surgical interventions hospital stay patients li ei 75 patients li group patients younger gestational age lower bw significant regional differences timing treatment hospitals west performed ei whereas hospitals south performed li even adjustment gestational age bw li group associated longer median los total hospital charges compared ei group temporary csf diversion procedures occurred ei group whereas permanent csfdiverting shunts placed li group shuntdevice replacement complications differ two groups li group 25fold higher odds sepsis p 0001 almost 2fold higher odds retinopathy prematurity p 005 ei group timing phh interventions differs region united states whereas association potential benefits treatment timing suggests importance national consensus guidelines development guidelines informed data regarding treatment timing patient outcomes available large national data sets provide insights comorbidities complications phh interventions