Marc Evans|Kamlesh Khunti|Muhammad Mamdani|Claus B. Galbo-Jørgensen|Jens Gundgaard|Mette Bøgelund|Stewart B. Harris
Health-related quality of life associated with daytime and nocturnal hypoglycaemic events: a time trade-off survey in five countries
University Hospital Llandough|University of Leicester|University of Toronto|Novo Nordisk (Denmark)|Western University
hypoglycaemic events particularly nocturnal affect healthrelated quality life hrqol via acute symptoms altered behaviour fear future events examined respective disutility associated single event daytime nocturnal severe nonsevere hypoglycaemiarepresentative samples taken canada germany sweden united states united kingdom individuals completed internetbased questionnaire designed quantify hrqol associated different diabetes andor hypoglycaemiarelated health states hrqol measured utility scale 1 perfect health 0 death using time tradeoff method three populations studied 8286 respondents general population 551 people type 1 diabetes 1603 type 2 diabetes respondents traded life expectancy improved health states evaluated health states wellcontrolled diabetes diabetes nonseveresevere daytimenocturnal hypoglycaemic eventsin general population nonsevere nocturnal hypoglycaemic events associated 0007 disutility compared 0004 nonsevere daytime episodes equivalent significant 63 increase negative impact severe daytime nocturnal events associated 0057 0062 disutility respectively significantly differentthis study applies established health economic methodology derive disutilities associated hypoglycaemia stratified onset time severity using large multinational population reveals substantial individual cumulative detrimental effects hypoglycaemic events particularly nocturnal hrqol reinforcing clinical imperative avoiding hypoglycaemia