Sherly X. Li|Yi Zheng|Kevin Whelan|Helen Truby
The effect of communicating the genetic risk of cardiometabolic disorders on motivation and actual engagement in preventative lifestyle modification and clinical outcome: a systematic review and meta-analysis of randomised controlled trials
Medical Research Council|University of Cambridge|Medical Research Council|University of Cambridge|King's College London|Monash University
abstract genetic risk prediction chronic conditions including obesity diabetes cvd currently limited predictive power potential engage healthy behaviour change immense research interest aimed understand whether latter indeed true conducting systematic review metaanalysis investigating whether genetic risk communication affects motivation actual behaviour change towards preventative lifestyle modification included randomised controlled trials rct since 2003 investigating impact genetic risk communication health behaviour prevent cardiometabolic disease without restrictions age duration intervention language conducted randomeffects metaanalyses perceived motivation behaviour change clinical changes weight loss narrative analysis outcomes within thirteen studies reviewed five vignette studies hypothetical rct seven clinical rct consistent effect genetic risk actual motivation weight loss perceived motivation dietary change control v genetic risk group standardised mean difference smd 015 95 ci 103 073 p 074 actual change dietary behaviour similar results observed actual weight loss control v high genetic risk smd 029 kg 95 ci 074 131 p 058 review found clear consistent evidence genetic risk communication alone either raises motivation translates actual change dietary intake physical activity reduce risk cardiometabolic disorders adults thirteen studies eight high unclear risk bias additional largerscale highquality clinical rct warranted