Matt W Wright, Courtney L Thaxton, Tristan Nelson, Marina T DiStefano, Juliann M Savatt, Matthew H Brush, Gloria Cheung, Mark E Mandell, Bryan Wulf, T J Ward, Scott Goehringer, Terry O'Neill, Phil Weller, Christine G Preston, Ingrid M Keseler, Jennifer L Goldstein, Natasha T Strande, Jennifer McGlaughon, Danielle R Azzariti, Ineke Cordova, Hannah Dziadzio, Lawrence Babb, Kevin Riehle, Aleksandar Milosavljevic, Christa Lese Martin, Heidi L Rehm, Sharon E Plon, Jonathan S Berg, Erin R Riggs, Teri E Klein
Generating Clinical-Grade Gene-Disease Validity Classifications Through the ClinGen Data Platforms
Annual review of biomedical data science
gangrenous sigmoid volvulus significant impact morbidity mortality study conducted compare sigmoid resection primary anastomosis rpa sigmoid resection end colostomy hartmanns procedure gangrenous sigmoid volvulus systematic review metaanalysis study design employed summarize retrospective cohort prospective cohort randomised control trial studies published inception march 31 2023 searching performed medline cinahal web science google scholar cochrane library clinicaltrialsgov locate eligible articles data searching selection screening quality assessment included articles data extraction done two separate reviewers revman 54 software fixedeffect mantelhaenszel model stata version 14 used analyze data protocol registered prospero registration website crd42023413367 ten cohort studies one randomised control trial 724 patients found rated moderate quality overall mortality rpa 15 95ci 1119 hartmanns procedure 19 95ci 1523 resection primary anastomosis rpa gangrenous sigmoid volvulus slightly lower mortality rate stoma or09895ci 068142 p007 i243 statistically significant difference resection primary anastomosis rpa slightly higher morbidity rate hartmanns procedure or10195ci 066155 p030 i218 statistically significant difference sigmoid resection primary anastomosis rpa hartmanns procedure significant differences mortality morbidity treatment gangrenous sigmoid volvulus choice intervention gangrenous sigmoid volvulus individualized consideration different detrimental factors