Omid Khatin-Zadeh, Danyal Farsani, Zahra Eskandari
Embodiment of infinity in mathematics
Frontiers in psychology
educational attainment ea stable indicator socioeconomic status confirmed affect intracerebral hemorrhage ich mechanism relating ea ich still unknown explore causal relationship ea ich bidirectional twostep mendelian randomization mr study using summarylevel genomewide association study using gwas data cases controls european ancestry performed bidirectional twostep mr analyses explore causal relationship educational attainment ich understand mediating influence risk factors process also carried subgroup analysis according different sites deep lobar ich set sensitivity analyses performed test valid mr assumptions bidirectional mr analysis consistently demonstrated unidirectional causal effect revealing higher ea protective influence ich additional 1standard deviation sd increase genetically predicted years schooling associated reduced risk ich inverse variance weighted ivw 0381 95 ci 02640549 deep ich 0334 95 ci 02160517 lobar ich 0422 95 ci 02610682 mediating effect ea ich mediated via systolic blood pressure sbp 693 1201345 body mass index bmi 1787 3923464 mediating effect ea deep ich also mediated via sbp 785 1551507 bmi 1863 4023626 study provides robust genetic evidence supporting protective effect ea ich risk evidence effect ea deep ich partially mediated hypertension obesity validation needed ascertain whether findings applicable racial general population groups