Fatemeh Kebriaei, Hajar Attarzadeh, Leyli Sadri, Elnaz Foroughi, Mehdi Taghian, Soroush Sadri
Knowledge of Iranian Parents of Elementary School Children about Traumatic Dental Injuries and its Management
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prophylaxis reduces frequency bleeds boys severe hemophilia standard care management resourceabundant countries effect prophylaxis healthrelated quality life hrqol established sample sizes studies small explore relationship multiple factors influence hrqol aim study assess impact hemophilia severity treatment regimen hrqol establish minimum important difference mid using international level score distributions hrqol data pooled 7 studies across 9 countries hrqol measured using canadian hemophilia outcomeskids life assessment tool choklat mixedeffect linear regression analysis employed assess impact prophylaxis choklat score data 401 boys hemophilia analyzed 576 severe hemophilia 576 receiving prophylaxis model revealed receiving prophylaxis significantly associated higher hrqol regression coefficient 85 95 confidence interval ci 39131 boys severe hemophilia significantly lower hrqol compared boys moderate mild hemophilia whose choklat scores 70 66 points higher respectively significant interaction treatment disease severity p 0023 indicating prophylaxis significant impact boys severe hemophilia based pooled data mid choklat established 65 study confirms positive effect prophylaxis hrqol boys hemophilia realworld setting provides initial benchmarks interpreting hrqol scores based use choklat instrument