Haein Lee, In Seo La
Association between health literacy and self-management among middle-aged women: A systematic review
Patient education and counseling
beginning twentieth century sir ronald fisher introduced concept applying statistical analysis planning stages research rather end experimentation statistical thinking applied design phase enables build quality product adopting demings profound knowledge approach comprising system thinking variation understanding theory knowledge psychology pharmaceutical industry late adopting paradigms compared sectors heavily focused blockbuster drugs formulation development mainly performed one factor time ofat studies rather implementing quality design qbd modern engineeringbased manufacturing methodologies among various mathematical modeling approaches design experiments doe extensively used implementation qbd research industrial settings qbd product process understanding key enabler assuring quality final product knowledge achieved establishing models correlating inputs outputs process mathematical relationships critical process parameters cpps material attributes cmas critical quality attributes cqas define design space consequently process understanding well assured rationally leads final product meeting quality target product profile qtpp review illustrates principles quality theory work major contributors evolution qbd approach statistical toolset implementation doe presented detail since represents first choice rational pharmaceutical development