Jian Zhao, Xin Gong, Jian Ding, Kepin Xiong, Kangle Zhuang, Rui Huang, Shu Li, Huachun Miao
Integration of case-based learning and three-dimensional printing for tetralogy of fallot instruction in clinical medical undergraduates: a randomized controlled trial
BMC medical education
whether used describe fitness genome architecture spatial distribution environmental variables concept landscape figured prominently collective reasoning tradition landscapes evolutionary biology one fitness mapped onto axes defined phenotypes molecular sequence states characteristics landscapes depend natural selection structured across genomic environmental landscapes thus bridge among differing uses landscape concept ie metaphorically literally adaptive phenotype distribution across geographical landscapes relation selective pressures one ultimate goals evolutionary biology thus construct fitness landscapes geographical space natural plant populations ideal systems explore feasibility attaining goal much known quantitative genetic architecture complex traits many different plant species less known molecular components architecture issue molecular ecology parchman et al 2012 pioneer one first truly genomewide association studies tree moves us closer form mechanistic understanding adaptive phenotype natural populations lodgepole pine pinus contorta dougl ex loud