Bandar Alsaif, Sehar-Un Nisa Hassan, Mohamed Ali Alzain, Ali A Almishaal, Aqeela Zahra
Cognitive Flexibility's Role in Reducing Academic Stress During the COVID-19 Pandemic
Psychology research and behavior management
genetic surveillance malaria parasites supports malaria control programmes treatment guidelines elimination strategies surveillance studies often pose questions malaria parasite ancestry eg antimalarial resistance spread employ statistical methods characterise parasite population structure many methods used characterise structure unsupervised machine learning algorithms depend genetic distance matrix notably principal coordinates analysis pcoa hierarchical agglomerative clustering hac pcoa hac sensitive definition genetic distance algorithmic specification importantly neither algorithm infers malaria parasite ancestry pcoa hac inform eg via exploratory data visualisation hypothesis generation answer comprehensively key questions malaria parasite ancestry illustrate sensitivity pcoa hac using 393 plasmodium falciparum whole genome sequences collected cambodia neighbouring regions antimalarial resistance emerged spread recently provide tentative guidance use interpretation pcoa hac malaria parasite genetic epidemiology guidance includes call fully transparent reproducible analysis pipelines feature clearly outlined scientific question ii clear justification analytical methods used answer scientific question along discussion inferential limitations iii publicly available genetic distance matrices downstream analyses depend iv sensitivity analyses bridge inferential disconnect output noninferential unsupervised learning algorithms scientific questions interest tailormade statistical models needed infer malaria parasite ancestry absence models speculative reasoning feature discussion results