Riccardo E. Marioni|Ardo van den Hout|Michael Valenzuela|Carol Brayne|Fiona E. Matthews
Active Cognitive Lifestyle Associates with Cognitive Recovery and a Reduced Risk of Cognitive Decline
University of Cambridge|MRC Biostatistics Unit|UNSW Sydney|University of Cambridge|MRC Biostatistics Unit
education lifestyle factors linked complex mental activity thought affect progression cognitive declinecollectively factors combined create cognitive reserve cognitive lifestyle scorethis study tested association cognitive lifestyle score cognitive change populationbased cohort older persons five sites across england walesdata came 13004 participants medical research council cognitive function ageing study aged 65 years overcognition assessed multiple waves 16 years using minimental state examinationsubjects grouped four cognitive states impairment slight impairment moderate impairment severe impairment cognitive lifestyle score assessed composite measure education midlife occupation current social engagementa multistate model used test effect cognitive lifestyle score cognitive transitionshazard ratios cognitive lifestyle score showed significant differences upper compared lower tertile active cognitive lifestyle associating decreased risk moving slight impairment 058 95 ci 045 074 recovery slightly impaired state back nonimpaired state 293 135 638 increased mortality risk severely impaired state 128 112 145an active cognitive lifestyle associated favorable cognitive trajectory older personsfuture studies would ideally incorporate neuroradiological neuropathological data determine causal evidence associations