Carlos M Herrera
Plant Phenotypes as Distributions: Johannsen's Beans Revisited
The American naturalist
genomewide association studies gwas identified several genetic variants associated major depression disorder mdd however pinpointing causal variants responsible association signal risk locus remains major challenge used summary databased mendelian randomization smr psychiatric genomics consortium pgc gwas summary brain expression quantitative trait loci eqtl data identify genes whose expression levels causally associated mdd performed differential expression analysis methylation quantitative trait loci analysis cognitive genetics analysis investigate potential roles risk genes pathogenesis mdd smr integrative analysis identified snp rs10789336 located neuronal growth regulator 1 negr1 gene significantly affected expression level rpl31p12 brain tissues contributed risk mdd p 196 106 consistently snp rs10789336 associated methylation levels three nearby dna methylation sites including cg09256413 negr1 p172 1010 cg11418303 prostaglandin e receptor 3 ptger3 p 478 106 cg23032215 zranb2 antisense rna 2 zranb2as2 p 123 104 differential expression analysis suggested negr1 gene upregulated prefrontal cortex p 514 103 cognitive genetics analysis showed snp rs10789336 associated cognitive performance p 241 1016 educational attainment p 175 1014 general cognitive function p 265 1012 verbal numerical reasoning p 136 1012 collectively results revealed snp rs10789336 negr1 might confer risk mdd investigation roles negr1 pathogenesis mdd warranted