Francesco Tomaiuolo
Gross morphology and morphometric sequelae in the hippocampus, fornix, and corpus callosum of patients with severe non-missile traumatic brain injury without macroscopically detectable lesions: a T1 weighted MRI study
gross morphology morphometry hippocampus fornix corpus callosum patients severe nonmissile traumatic brain injury nmtbi without obvious neuroradiological lesions examined volumes structures correlated performance memory tests addition predictability length coma selected anatomical volumes examinedhigh spatial resolution t1 weighted mri scans brain 1 mm3 neuropsychological evaluations standardised tests performed least 3 months trauma 19 patientsin comparison control subjects matched terms gender age volume reduction hippocampus fornix corpus callosum nmtbi patients quantitatively significant length coma correlated volume reduction corpus callosum immediate free recall word lists correlated volume fornix corpus callosum delayed recall word lists immediate recall rey figure correlated volume fornix delayed recall rey figure correlated volume fornix right hippocampusthese findings demonstrate severe nmtbi without obvious neuroradiological lesions clear hippocampal fornix callosal volume reduction length coma predicts callosal volume reduction could considered marker severity axonal loss memory test scores correlated volumes selected anatomical structures relationship memory performance may reflect diffuse nature damage leading disruption neural circuits multiple levels progressive neural degeneration occurring tbi