Teshome Bekana, Wei Hu, Song Liang, Berhanu Erko
Transmission of Schistosoma mansoni in Yachi areas, southwestern Ethiopia: new foci
Infectious diseases of poverty
schizophrenia scz patients exhibit 30 higher prevalence metabolic syndrome mets compared general population suboptimal management contributing increased mortality largescale studies providing realworld evidence underlying causes remain limited address gap used realworld health data estonian biobank spanning median followup ten years investigate impact genetic predisposition antipsychotic treatment development mets scz patients specifically set characterize antipsychotic treatment patterns genetic predisposition mets traits mets prognosis body mass index bmi trajectories comparing scz cases n 677 age sexmatched controls n 2708 scz cases exhibited higher genetic predisposition scz 175 95 ci 158194 lower polygenic burden increased bmi 088 95 ci 088096 creactive protein 088 95 ci 081097 compared controls scz cases showed worse prognosis mets hr 195 95 ci 154246 higher antipsychotic adherence within first treatment year associated reduced longterm mets incidence linear mixed modelling incorporating multiple bmi timepoints underscored significant contribution antipsychotic medication genetic predisposition higher bmi driving substantially upward trajectory bmi scz cases findings contribute refining clinical risk prediction prevention strategies mets among scz patients emphasize significance incorporating genetic information longterm patient tracking employing diverse perspectives analyzing realworld health data eu horizon 2020 swedish research council estonian research council estonian ministry education research university tartu