Josiah D. Allen|Lusi Zhang|Alyssa N. K. Johnson|Pamala A. Jacobson|Catherine A. McCarty|Amy L. Pittenger|Jeffrey R. Bishop
Development and Validation of the Minnesota Assessment of Pharmacogenomic Literacy (MAPL)
St. Elizabeth Healthcare|Genomic Health (United States)|University of Minnesota|University of Minnesota|University of Minnesota|University of Minnesota, Duluth|University of Minnesota|University of Minnesota Medical Center|University of Minnesota
ensuring patients adequate understanding pharmacogenomic pgx test results critical component implementing precision medicine clinical care however pgxspecific validated literacy assessment yet developed address need developed validated minnesota assessment pharmacogenomic literacy mapltm foundational work included scoping review patient general public attitudes experiences pharmacogenomic testing three focus groups readability assessments review experts members general public resulted 15item assessment designed assess knowledge four domains underlying concepts limitations benefits privacy validation 646 participants completed mapl part larger survey pharmacogenomic research statewide pgx implementation two items deemed easy dropped remaining 13 items retained final mapl good internal reliability cronbachs alpha 075 confirmatory factor analysis validated fourdomain construct mapl suggested good model performance high internal validity estimated coefficient loadings across 13 questions corresponding domains positive statistically significant p 005 mapl covers multiple knowledge domains specific relevance pgx useful tool clinical research settings quantitative assessment pgx literacy value