Bridget Candy|Trudie Chalder|Anthony J. Cleare|A. Peakman|Ania Skowera|Simon Wessely|John Weinman|Mark Zuckerman|Matthew Hotopf
Predictors of fatigue following the onset of infectious mononucleosis
St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College|St Thomas' Hospital|The King's College
infectious mononucleosis im risk factor chronic fatigue reduced activity consistent factor found associated poor outcome following onset infectious mononucleosis however little known biological mechanisms involved pathogenesis chronic fatigue following im study far examined relation certain illness beliefs poor outcome study explored immunological endocrine behavioural cognitive responses acute illness assessed components groups risk factors predicted chronic courseusing prospective cohort design 71 primary care patients im enrolled onto study interviewed recovery explored postal questionnaire 1 year laterin univariate analysis increased baseline levels immune activation associated fatigue baseline 3 months cortisol levels associated fatigue point using multivariate models clinical psychosocial baseline factors severity symptoms illness perceptions found predict fatigue 3 months later 6 months fatigue best predicted female gender illness perceptions 12 months female gender symptomsdisability factorin multivariate analysis factors found predict poor outcome timepoints instead pattern predictors changed time partly completely consistent priori predictions larger studies needed explore predictive nature biopsychosocial factors pathogenesis chronic fatigue related im psychobehavioural predictors found study amenable intervention interventions tested randomized controlled trials