Margaret Bevans|Sandra A. Mitchell|John Barrett|Michael Bishop|Richard Childs|Daniel H. Fowler|Michael Krumlauf|Patricia Prince|Nonniekaye Shelburne|Leslie Wehrlen|Li Yang
Symptom Distress Predicts Long-Term Health and Well-Being in Allogeneic Stem Cell Transplantation Survivors
National Institutes of Health Clinical Center|Applied Research (United States)|National Cancer Institute|National Heart Lung and Blood Institute|University of Chicago|National Heart Lung and Blood Institute|National Cancer Institute|National Institutes of Health Clinical Center|National Institutes of Health Clinical Center|Applied Research (United States)|National Cancer Institute|National Institutes of Health Clinical Center|National Institutes of Health Clinical Center
number survivors allogeneic hematopoietic stem cell transplantation hsct continues increase yet survivorship experience fully characterized study examines health status healthrelated quality life hrql hsct survivors aims study 1 explore baseline change time health outcomes 2 characterize subgroups experiencing adverse outcomes longitudinal study adults survived 3 years date allogeneic hsct completed series patientreported outcome measures annually including measures health status hrql symptoms data analyzed using hierarchical linear modeling subjects n 171 average 44 135 years age primarily male 626 40 hispanic mean scores physical mental health hrql preserved relative population norms hierarchical linear modeling revealed significant change mean trajectories outcomes although significant betweenindividual variability observed controlling demographic clinical factors physical symptom distress negatively affected outcomes impact symptom distress physical health varied based time since hsct impairment physical health greatest survivors experiencing high symptom distress within first decade post transplantation extended treatment systemic immunosuppressive therapy also predicted inferior physical health findings suggest patientcentered outcomes preserved relative normative values generally stable allogeneic hsct although survivors persistent symptoms receiving systemic immunosuppression experience impairments health status hrql