Zerina Lokmic-Tomkins, Kalpana Raghunathan, Helen Almond, Richard G Booth, Susan G McBride, Mari Tietze, Michelle Honey, Paula Procter, Monica Peddle, Lisa McKenna
Perspectives on the implementation of health informatics curricula frameworks
Contemporary nurse
prior research demonstrated relationship sleep cognitive performance sleep relates underlying genetic environmental etiologies contributing cognitive functioning regardless level cognitive function unclear present study assessed whether importance genetic environmental contributions cognition vary depending individuals agingrelated sleep characteristics large sample consisted twins six studies within interplay genes environment across multiple studies igems consortium spanning mid latelife average age mage 576 range 2791 years n 7052 female 4370 1525 complete monozygotic mz pairs 2001 complete dizygotic dz pairs quantitative genetic twin models considered sleep duration primary moderator genetic environmental contributions cognitive performance four cognitive abilities semantic fluency spatialvisual reasoning processing speed episodic memory accounting age moderation results suggested genetic shared nonshared environmental contributions semantic fluency genetic shared environmental contributions episodic memory vary sleep duration significant moderation observed spatialvisual reasoning processing speed results semantic fluency episodic memory illustrated patterns higher genetic influences cognitive function shorter sleep durations ie 4 hours higher shared environmental contributions cognitive function longer sleep durations ie 10 hours overall findings may align associations upregulation neuroinflammatory processes ineffective betaamyloid clearance short sleep contexts common reporting mental fatigue long sleep contexts associated poorer cognitive functioning