Saskia Sendatzki, Ronja Maren Helmchen, Irene Moor, Gorden Sudeck, Kevin Dadaczynski, Katharina Rathmann
Health literacy of students in Germany - Results of the HBSC study 2022
Journal of health monitoring
anemia significant contributor global disease burden thalassemia common hereditary anaemic disease previous estimates based data geographically limited lacked comprehensive global analysis study provides prevalence incidence mortality disabilityadjusted life years dalys thalassemia 204 countries regions thalassemia 1990 2021 focusing age structure time trends disease burden provide effective information health policy allocation medical resources optimization patient management programs using standardised global burden disease gbd methodologies aimed derive precise representation health burden posed thalassemia considering four distinct types epidemiological data namely incidence birth prevalence mortality dalys presented data meticulously estimated displayed numerical counts agestandardised rates per 100000 persons population accompanied uncertainty interval ui highlight potential statistical variability temporal trends spanning years 19902021 subjected rigorous examination utilizing joinpoint regression analysis methodological approach facilitated computation annual percentage change apc average annual percentage change aapc along corresponding 95 confidence intervals cis globally agestandardized prevalence rates aspr agestandardized incidence rates asir agestandardized mortality rates asmr agestandardized dalys rates thalassemia 2021 1828 per 100000 persons 95 ui 15292202 193 per 100000 persons 95 ui 151249 015 per 100000 persons95 ui 011020 1165 per 100000 persons 95 ui 8241494 respectively compared 1990 rates decreased 018 95 ui 022 014 025 95 ui 030 019 048 95 ui 060 028 049 95 ui 062 029 respectively 2021 asir thalassemia highest east asia 735 per 100000 persons 95 ui 5371004 asmr highest southeast asia 037 per 100000 persons 95 ui 029045gender comparisons showed negligible differences disease burden highest prevalence noted children five decreasing age global aspr asmr declined 1990 2021 overall though increasing trend prevalence found among elderly joinpoint analysis revealed global aspr increased 2018 2021 apc 92 95 ci 48138 p 0001 asir decreased apc 768 95 ci 1088 436 p 0001 significant rise asmr 2019 2021 apc 48 95 ci 0196 p 005 trends aspr asmr varied across regions notable changes south asia global burden thalassemia reflected prevalence incidence mortality dalys exhibits significant disparities geographic demographic shifts disease distribution observed 1990 2021 overall decrease burden yet increase cases among elderly population analysis epidemiological trends time highlights influence health policies significant public health interventions thalassemia outcomes data crucial healthcare professionals policymakers researchers refine enhance management strategies aiming mitigate thalassemias global impact national natural science foundation china guizhou province science technology project guizhou province science technology foundation health commission