Ramadass Balamurugan|Harish P. Janardhan|Sarah L. George|Sucharita Priya Chittaranjan|B. S. Ramakrishna
Bacterial succession in the colon during childhood and adolescence: molecular studies in a southern Indian village
Christian Medical College & Hospital|Christian Medical College & Hospital|Christian Medical College & Hospital|Christian Medical College & Hospital|Christian Medical College & Hospital
colonic bacterial flora largely anaerobic believed establish stabilize first 2 lifethis study undertaken determine whether bacterial flora colon undergoes changes succession childhood adolescencethis crosssectional study examined fecal samples 130 healthy children adolescents age group 217 30 healthy adults median age 42 residing single village southern india dna extracted subjected 16s rdnatargeted realtime polymerase chain reaction determine relative predominance bifidobacterium genus bacteroidesprevotellaporphyromonas group lactobacillus acidophilus group eubacterium rectale faecalibacterium prausnitziibifidobacterium species bacteroidesprevotella group dominant fecal bacteria overall e rectale lactobacillus species considerably less abundant clear agerelated differences emerged steep decline bifidobacterium species adults p 00001 steep decline lactobacillus species 5 age p 00001 increase bacteroides late adolescence adults p 00040 increase e rectale childhood adolescence followed steep decline adults p 00001 late childhood peak f prausnitzii decline adolescents adults p 00001changes bacterial flora occur childhood adolescence characterized reduction lactobacillus bifidobacterium species increase bacteroides e rectale f prausnitzii peaked late childhood population