Nicola J Simkiss, Nicola S Gray, Andrew H Kemp, Chris Dunne, Robert J Snowden
A randomised controlled trial evaluating the Guide Cymru mental health literacy intervention programme in year 9 (age 13-14) school pupils in Wales
BMC public health
ages stages questionnaire asq commonly used developmental screening tool utility debated conduct systematic review metaanalysis evaluate asqs utility screening diagnostic tool identify developmental delay children aged 1260 months medline embase cinahl psycinfo mednar searched inception december 2021 studies meeting criteria included asq performed age 12 60 months median age asq least 12 months formal developmental assessments done within 2 months asq true positive false positive false negative true negatives individual studies extracted metaanalysis conducted stata version 161 risk bias assessed using quadas2 tool certainty evidence coe assessed using grade guidelines ability asq scores 2 sds mean 1 domain asq2sd identify developmental delay severe delay based generally accepted interpretation likelihood ratio lr values positive lr plr 5 negative lr nlr 02 less considered necessary rule rule developmental delay respectively least moderate probability initial search yielded 5777 citations 43 included review 36 included metaanalysis pooled sensitivity specificity plr nlr follows asq2sd predict delay 1 domain n 16 077 95 ci 064086 081 95 ci 075086 410 95 ci 317530 028 95 ci 018044 asq2sd predict severe delay 1 domain n 15 084 95 ci 075090 077 95 ci 071082 372 95 ci 298464 020 95 ci 013032 asq2sd motor domain predict motor delay n 7 041 95 ci 026057 094 95 ci 087097 65 95 ci 38111 063 95 ci 050081 asq2sd cognitive domain predict cognitive delay n 2 044 95 ci 024065 093 95 ci 081095 64 95 ci 24168 061 95 ci 043086 coe lowvery low child aged 12 60 months passes asq domains moderate probability severe developmental delay low coe child aged 1260 months fails motor cognitive domain asq moderate probability motor cognitive delay respectively low coe prospero crd42021268543