Wei Guo, Bao-Li Li, Jian-Yong Zhao, Xiao-Ming Li, Lin-Feng Wang
Causal associations between modifiable risk factors and intervertebral disc degeneration
The spine journal : official journal of the North American Spine Society
across age groups differences connectivity mesolimbic prefrontal cortex covary trait impulsivity sensationseeking impulsivity sensationseeking also known increase early adolescence maturation subcortical structures outpaces prefrontal cortex imbalance striatum prefrontal cortex considered normal developmental process higher levels adolescent impulsivity sensationseeking associated increased risk diverse problems including obesityto determine relationship sensationseeking impulsivity body mass index bmi related shared neural correlates measured relationships connectivity nuclei striatum dopaminergic midbrain young adolescents data collected 116 children ages 12 14 included resting state functional magnetic resonance imaging personality measures substance use risk profile scale bmi zscore age shared variance connectivity regions interest substantia nigra ventral tegmental area ventral striatum subthalamic nucleus personality measures bmi zscore age analyzed using partial least squares correlationthis analysis identified single significant striatolimbic network connected substantia nigra ventral tegmental area subthalamic nuclei p 0002 connectivity within network included hippocampi amygdalae parahippocampal gyri regions interest correlated positively impulsivity bmi zscore age negatively sensationseeking together findings emphasize addition wellestablished role frontostriatal circuits play development adolescent personality traits connectivity limbic regions striatum midbrain also impact impulsivity sensationseeking bmi zscore adolescents