M. Kumi Smith|Kimberly A. Powers|Kathryn E. Muessig|William C. Miller|Myron S. Cohen
HIV Treatment as Prevention: The Utility and Limitations of Ecological Observation
University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill
results several observational studies hivdiscordant couples randomized controlled trial hiv prevention trials network 052 show antiretroviral therapy art greatly reduce heterosexual hiv transmission stable hivdiscordant couples however data prove art reduce hiv incidence population level observational investigations using ecological measures used support implementation hiv treatment specific purpose preventing transmission population level many studies note ecological associations measures increased art uptake decreased hiv transmission given urgency implementing hiv prevention measures ecological studies must de facto used inform current strategies however hypothesis widespread art eliminate hiv infection may raised expectations beyond may able achieve review discuss construct exposure outcome measures analysis methods used ecological studies examining strengths weaknesses ecological analyses aim aid understanding findings studies inform future policy decisions regarding use art hiv prevention