Titiane Dallant, Amandine Bozonnet, Elisabeth Delarocque-Astagneau, Sylvain Gautier, Ali Koné, Vincent Grasteau, Alexandra Rouquette, Marie Herr
Development and evaluation of a food literacy questionnaire for schoolchildren in France
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alcohol consumption significantly impacts disease burden linked various diseases observational studies however comprehensive metaanalyses using mendelian randomization mr examine drinking patterns limited aimed evaluate health risks alcohol use integrating findings mr studies thorough search conducted mr studies focused alcohol exposure utilized two sets instrumental variablesalcohol consumption problematic alcohol useand summary statistics finngen consortium r9 release perform de novo mr analyses metaanalysis encompassed 64 published 151 de novo mr analyses across 76 distinct primary outcomes results show genetic predisposition alcohol consumption independent smoking significantly correlates decreased risk parkinsons disease prostate hyperplasia rheumatoid arthritis also associated increased risk chronic pancreatitis colorectal cancer head neck cancers additionally genetic predisposition problematic alcohol use strongly associated increased risks alcoholic liver disease cirrhosis acute chronic pancreatitis pneumonia evidence mr study supports notion alcohol consumption problematic alcohol use causally associated range diseases predominantly increasing risk