Martyn R Partridge|Marc Miravitlles|Elisabeth Ståhl|Niklas Karlsson|Kristoffer Svensson|Tobias Welte
Development and validation of the Capacity of Daily Living during the Morning questionnaire and the Global Chest Symptoms Questionnaire in COPD
Charing Cross Hospital|Imperial College London|Fundació Clínic per a la Recerca Biomèdica|AstraZeneca (Spain)|Consorci Institut D'Investigacions Biomediques August Pi I Sunyer|Charing Cross Hospital|Imperial College London|AstraZeneca (Sweden)|Medizinische Hochschule Hannover
report concerns development validation two patientreported outcomes questionnaires developed assess chronic obstructive pulmonary disease copd patients ability perform morning activities evaluate morning symptoms based interviews copd patients capacity daily living morning cdlm questionnaire global chest symptoms questionnaire gcsq developed linguistically validated incorporated two multicentre randomised trials involving total 1100 copd patients trials registered clinicaltrialsgov nct00496470 nct00542880 data trials used determine reliability validity responsiveness questionnaires derive estimates minimal important differences mids questionnaires displayed goodtohigh reliability cronbachs alpha 075093 analysis convergent validity showed cdlm gcsq scores correlated significantly p0001 symptoms healthrelated quality life hrqol use rescue medication trials cdlm gcsq scores discriminated patients different levels hrqol assessed st georges respiratory questionnaire copd patients sgrqc disease severity assessed global initiative chronic obstructive lung disease gold criteria significant improvement cdlm gcsq scores occurred response treatment estimations mid scores corresponding sgrqc mid 4 020 cdlm questionnaire 015 gcsq cdlm questionnaire gcsq easytouse reliable responsive selfadministered questionnaires report patients symptoms ability perform morning activities