Sandra K. Pope|Stephen B. Kritchevsky|Christine B. Ambrosone|Kristine Yaffe|Frances A. Tylavsky|Eleanor M. Simonsick|Caterina Rosano|Scott A. Stewart|Tamara B. Harris
Myeloperoxidase Polymorphism and Cognitive Decline in Older Adults in the Health, Aging, and Body Composition Study
University of Arkansas for Medical Sciences|Wake Forest University|Roswell Park Comprehensive Cancer Center|University of California, San Francisco|University of Tennessee Health Science Center|National Institutes of Health|University of Pittsburgh|University of Arkansas for Medical Sciences|National Institutes of Health
myeloperoxidase antimicrobial enzyme produces oxidative free radicals rarely found normal brain tissue myeloperoxidase detected microglia associated alzheimers disease plaques authors examined g463a polymorphism promoter region myeloperoxidase gene mpo determine relation mpo variants cognitive decline 4 years cohort adults aged 7079 years baseline 19971998 recruited memphis tennessee pittsburgh pennsylvania health aging body composition study sample 8 participants aa 369 ag 552 gg genotype mpo frequency aa ag genotypes higher blacks whites 112 vs 59 441 vs 329 respectively multivariate logistic regression analyses showed participants mpo aa genotype cognitive decline 158 95 confidence interval 107 235 times likely participants ag genotype 196 95 confidence interval 133 288 times likely gg genotype interactions mpo race sex apolipoprotein gene significant sample mpo aa associated decreased production myeloperoxidase found risk factor cognitive decline