Thi Huyen Trang Nguyen, Thi Tra Bui, Jinhee Lee, Kui Son Choi, Hyunsoon Cho, Jin-Kyoung Oh
Socioeconomic inequality in health-related quality of life among Korean adults with chronic disease: an analysis of the Korean Community Health Survey
Epidemiology and health
brain white matter hyperintensities seen routine clinical imaging 46 adults congenital adrenal hyperplasia cah extent functional relevance abnormalities studied quantitative magnetic resonance imaging mri analysis examine white matter microstructure neural volumes central nervous system cns metabolites cah due 21hydroxylase deficiency 21ohd determine whether identified abnormalities associated cognition glucocorticoid androgen exposure crosssectional study tertiary hospital including 19 women 18 50 years 21ohd 19 agematched healthy women recruits underwent cognitive assessment brain imaging including diffusion weighted imaging white matter t1weighted volumetry magnetic resonance spectroscopy neural metabolites evaluated white matter microstructure using tractbased spatial statistics compared cognitive scores neural volumes metabolites groups relationships glucocorticoid exposure mri neurologic outcomes patients 21ohd widespread reductions white matter structural integrity reduced volumes right hippocampus bilateral thalami cerebellum brainstem reduced mesial temporal lobe total choline content working memory processing speed digit span matrix reasoning scores reduced patients 21ohd despite similar education intelligence controls patients 21ohd exposed higher glucocorticoid doses greater abnormalities white matter microstructure cognitive performance demonstrate 21ohd current glucocorticoid replacement regimens profound impact brain morphology function reversible cns markers potential target treatment