Karl Bang Christensen, Aake Packness, Erik Simonsen, John Brodersen
Psychometric validation of the Danish version of the Major Depression Inventory using data from the Lolland-Falster health study (LOFUS)
Nordic journal of psychiatry
despite overwhelming evidence multiple sclerosis autoimmune disease relatively little known precise nature immune dysregulation underlying development disease reasoning csf patients might enriched cells relevant pathogenesis completed highresolution singlecell analysis 96 732 csf cells collected 33 patients multiple sclerosis n 48 675 48 patients neurological diseases n 48 057 completing comprehensive cell type annotation identified rare population cd8 cells characterized upregulation inhibitory receptors increased patients multiple sclerosis applying multiomics factor analysis singlecell data revealed activity pathways responsible controlling inflammatory type 1 interferon responses altered multiple sclerosis cells myeloid cells also undertook systematic search expression quantitative trait loci csf cells particular interest two expression quantitative trait loci cd8 cells fine mapped multiple sclerosis susceptibility variants viral control genes zc3hav1 rs10271373 ifitm2 rs1059091 analysis suggests associations likely reflect genetic effects rna splicing celltype specific gene expression respectively collectively study suggests alterations viral control mechanisms might important development multiple sclerosis