Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions
European journal of preventive cardiology
familial hypercholesterolaemia fh increases propensity premature atherosclerotic disease knowledge inpatient outcomes among patients fh admitted acute myocardial injury ami limited study aimed identify myocardial injury types including type 1 myocardial infarction mi type 2 mi takotsubo cardiomyopathy assess lesion severity study adverse shortterm inpatient outcomes among patients fh admitted ami study retrospectively queried us national inpatient sample 2018 2020 adults admitted ami dichotomised based presence fh evaluated myocardial injury types complexity coronary revascularisation primary outcome allcause mortality clinical secondary outcomes studied 3 711 765 admissions ami including 2360 006 fh fh associated higher odds stelevation mi stemi adjusted aor 162 p0001 nonstelevation mi nstemi aor 129 p0001 lower type 2 mi aor 039 p0001 takotsubo cardiomyopathy aor 036 p0004 fh associated higher multistent percutaneous coronary interventions aor 236 p0001 multivessel coronary artery bypass aor 265 p0001 higher odds intracardiac thrombus aor 328 p0038 mechanical circulatory support aor 179 p0001 50 reduction odds allcause mortality aor 050 p0006 lower odds mechanical ventilation aor 037 p0001 difference rate ventricular tachycardia cardioversion new implantable cardioverter defibrillator implantation cardiogenic shock cardiac arrest among patients hospitalised ami fh associated higher stemi nstemi lower type 2 mi takotsubo cardiomyopathy higher number multiple stents coronary bypasses mechanical circulatory support device associated lower allcause mortality rate mechanical ventilation