Sa'ed M Atallah, Madi T Al-Jaghbir, Ayman A Zayed
The prevalence of diabetic peripheral neuropathy among diabetic Palestinian refugees in the Nuzha area, Jordan: a cross-sectional study
Lancet (London, England)
untranslated region utr messenger ribonucleic acid mrna including 5utr 3utr plays critical role regulating gene expression translation variants within utr lead changes associated human traits diseases however computational prediction utr variant effect challenging current noncoding variant prediction mainly focuses promoters enhancers neglecting unique sequence utr thereby limiting predictive accuracy study using consolidated datasets utr variants disease databases largescale experimental data systematically analyzed 50 regionspecific features utr including functional elements secondary structure sequence composition site conservation analysis reveals certain features cgrelated sequence composition 5utr atrelated sequence composition 3utr effectively differentiate nonfunctional functional variant sets unveiling potential sequence determinants functional utr variants leveraging insights developed two classification models predict functional utr variants using machine learning achieving area curve auc value 094 5utr 085 3utr outperforming existing methods models valuable enhancing clinical interpretation genetic variants facilitating prediction management disease risk