Anna Adelheid Lange, Raphaël Bonvin, Sissel Guttormsen, Sofia Carolina Zambrano Ramos
Physicians' emotion awareness and emotion regulation training during medical education: a systematic scoping review protocol
BMJ open
current guidelines recommend amiodarone dronedarone rhythm control patients atrial fibrillation af coronary artery disease cad comparative study antiarrhythmic drugs aads cardiovascular outcomes general practice study included patients af cad received first prescription amiodarone class ic aads flecainide propafenone dronedarone sotalol january 2016 december 2020 primary outcome composite hospitalization heart failure hhf stroke acute myocardial infarction ami cardiovascular death used cox proportional regression models including inverse probability treatment weighting iptw estimate relationship aads cardiovascular outcomes among af cohort consisting 8752 patients 1996 individuals cad including 477 took dronedarone 1519 took aads median followup 38 months 463 patients took dronedarone 544 patients took aads experienced cardiovascular events compared dronedarone use aads associated increased cardiovascular events adjusting covariates hazard ratio hr 1531 95 confidence interval ci 11122141 p 0023 iptw hr 1491 95 ci 11741992 p 0012 secondary analysis showed amiodarone class ic drugs associated increased risk hhf low number subjects sotalol group limits data interpretation patients af cad dronedarone associated better cardiovascular outcomes aads amiodarone class ic aads associated higher risk cardiovascular events particularly hhf