Katri Kaajalaakso, Lotta Lempinen, Terja Ristkari, Jukka Huttunen, Terhi Luntamo, Andre Sourander
Psychometric properties of the screen for child anxiety related emotional disorders (SCARED) among elementary school children in Finland
Scandinavian journal of psychology
psoriasis inflammatory skin disease estimated heritability around 70 previous genomewide association studies gwass detected several risk loci psoriasis improve understanding genetic risk factors impacting disease conducted discovery gwas finngen subsequent replication metaanalysis data estonian biobank uk biobank study sample included 925 649 individuals 22 659 cases 902 990 controls largest sample psoriasis yet addition conducted downstream analyses find psoriasis crosstrait genetic correlations causal relationships report 6 risk loci knowledge previously unreported harbor genes related nuclear factor kappalightchainenhancer activated bcellssignaling pathway overall immunity genetic correlations highlight relationship psoriasis smoking higher body weight lower education level additionally report causal relationships psoriasis mood symptoms well twodirectioned causal relationship psoriasis lower education level results provide knowledge psoriasis risk factors may useful development future treatment strategies