Lydia Lichtenberger-Geslin|Sophie Dos Santos|Yasmine Hassani|Emmanuel Écosse|T. Van Den Abbeele|Juliane Léger
Factors Associated With Hearing Impairment in Patients With Congenital Hypothyroidism Treated Since the Neonatal Period: A National Population-Based Study
Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Délégation Paris 7|Sorbonne Paris Cité|Université Paris Cité|Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Sorbonne Paris Cité|Université Paris Cité|Inserm|Hôpital Robert-Debré|Assistance Publique – Hôpitaux de Paris|Délégation Paris 7
context untreated hypothyroidism known impair hearing little known longterm hearing patients treated congenital hypothyroidism ch since neonatal period objective purpose study assess hearing determinants populationbased registry young adult patients ch design setting participants selfdeclared hearing loss evaluated 1202 1748 eligible patients ch completed questionnaire health status median age 234 years audiograms obtained one third patients declaring hearing loss 37 107 main outcome measures selfdeclared hearing loss audiogram characteristics patients reporting hearing impairment measured results patients risk selfdeclared hearing loss 3 times higher reference population relative risk rr 37 95 confidence interval ci 2947 hearing impairment diagnosed median age 70 25th75th percentiles 34190 years 17 affected patients required hearing support early adulthood hearing loss associated type ch patients athyreosis gland situ frequently affected ectopic gland rr 261 95 ci 177388 disease severity assessed bone maturation delay time diagnosis least one knee epiphyseal ossification center absent severe form rr 229 95 ci 139379 associated chronic diseases rr 364 95 ci 235562 trend association serum free t4 concentration diagnosis also observed rr 147 95 ci 096223 hearing loss mostly bilateral 90 mild moderate 96 sensorineural type 76 concerned high high frequencies conclusion despite major improvements prognosis hearing loss remains significant problem particularly patients severe ch parents primary care providers aware risk early diagnosis intervention could improve longterm prognosis patients