Dimitris Charalambos Karaferis, Dimitris A Niakas
Exploring Inpatients' Perspective: A Cross-Sectional Survey on Satisfaction and Experiences in Greek Hospitals
Healthcare (Basel, Switzerland)
despite recent advances prediction protein structures deep neutral networks elucidation proteinfolding mechanisms remains challenging promising theory describing protein folding coarsegrained statistical mechanical model called wakosaitmuozeaton wsme model model calculate freeenergy landscapes proteins based threedimensional structure low computational complexity thereby providing comprehensive understanding folding pathways structure stability intermediates transition states involved folding reaction review summarize previous recent studies protein folding dynamics performed using wsme model discuss future challenges prospects wsme model successfully predicted folding mechanisms small singledomain proteins effects aminoacid substitutions protein stability folding manner consistent experimental results furthermore extended versions wsme model applied predict folding mechanisms multidomain proteins conformational changes associated protein function thus wsme model may contribute significantly solving proteinfolding problem expected useful predicting protein folding stability dynamics basic research industrial medical applications