Nicoleta Spînu, Mark T D Cronin, Judith C Madden, Andrew P Worth
A matter of trust: Learning lessons about causality will make qAOPs credible
Computational toxicology (Amsterdam, Netherlands)
infants preterm born 32 weeks gestation low birth weight vlbw weighing 1500 g risk poor developmental outcomes increasing evidence preterm birth vlbw considerable effect motor development although findings inconsistent investigate relationship preterm birth vlbw motor development computerized databases embase pubmed web knowledge used search englishlanguage peerreviewed articles published january 1992 august 2009 studies included reported motor scores preterm vlbw children without congenital anomalies using 1 3 established widely used motor tests bayley scales infant development ii bsidii movement assessment battery children mabc bruininksoseretsky test motor proficiency botmp fortyone articles identified encompassing 9653 children comparison termborn peers preterm vlbw children obtained significantly lower scores 3 motor tests bsidii 088 95 confidence interval ci 096 080 p 001 mabc 065 95 ci 070 060 p 001 botmp 057 95 ci 068 046 p 001 whereas motor outcomes bsidii show catchup effect first years development r 050 p 01 results mabc demonstrate nonsignificantly greater deficit increasing age elementary school early adolescence r 059 p 07 born preterm vlbw associated significant motor impairment persisting throughout childhood