Alpesh A Patel, Joseph H Schwab, Derek F Amanatullah, Srikanth N Divi
AOA Critical Issues Symposium: Shaping the Impact of Artificial Intelligence within Orthopaedic Surgery
The Journal of bone and joint surgery. American volume
given lack definitive treatment poor prognosis patients diffuse midline glioma dmg diffuse intrinsic pontine glioma dipg socioeconomic status ses may affect treatment access therefore survival therefore study aimed examine relationship ses treatment modalities progressionfree survival pfs overall survival os children dmgdipg retrospective singleinstitution review conducted medical records patients 18 years age dmg dipg diagnosed 2000 2022 patient demographics surgical interventions chemotherapy radiation therapy clinical trial enrollment medical carerelated travel extracted ses variables education mean income associated patient census tracts collected stratified statistical analysis using unpaired ttests chisquare analysis logrank tests conducted 96 patients met inclusion criteria majority female 59 nonhispanic white 57 median pfs median os time diagnosis treatment differ racesethnicities sex ninetyone 96 patients census tract data available patients higherincome census tracts 50 families annual household income greater 50000 longer median os 480 vs 235 days p 0001 traveled significantly longer distances medical care 1550 vs 1114 miles p 0048 families lowerincome census tracts patients highest education quartile traveled significantly farther treatment lowest education quartile mean 2964 vs 478 miles p 0047 patients received oral intravenous chemotherapy likely higherincome census tracts received intravenous chemotherapy duration pfs rates clinical trial enrollment biopsy rates h3k27 mutation status ventriculoperitoneal shunt placement rates radiotherapy rates associated ses variables patients families higherincome census tracts experienced longer os traveled farther treatment patients families highereducationlevel census tracts traveled often treatment authors findings suggest ses influences dmg dipg os studies done understand role ses outcomes children dmgdipg