Chelsea A. Myers|Maaike Vandermosten|Emily A. Farris|Roeland Hancock|Paul Gimenez|Jessica M. Black|Brandi Casto|Miroslav Drahos|Mandeep Tumber|Robert L. Hendren|Charles Hulme|Fumiko Hoeft
White Matter Morphometric Changes Uniquely Predict Children’s Reading Acquisition
University of California, San Francisco|Parenting Research Centre|KU Leuven|University of California, San Francisco|The University of Texas of the Permian Basin|University of California, San Francisco|University of California, San Francisco|University of California, San Francisco|Boston College|University of California, San Francisco|Palo Alto University|University of California, San Francisco|University of California, San Francisco|Palo Alto University|University of California, San Francisco|University College London|University of California, San Francisco|Haskins Laboratories|Yale University|Keio University
study examined whether variations brain development kindergarten grade 3 predicted individual differences reading ability grade 3 structural mri measurements indicated increases volume two left temporoparietal white matter clusters unique predictors reading outcomes beyond family history socioeconomic status cognitive preliteracy measures baseline using diffusion mri identified left arcuate fasciculus superior corona radiata key fibers within two clusters biasfree regression analyses using regions interest prior literature revealed volume changes temporoparietal white matter together preliteracy measures predicted 56 variance reading outcomes findings demonstrate important contribution developmental differences areas left dorsal white matter often implicated phonological processing sensitive early biomarker later reading abilities extension reading difficulties