Manja Lehmann|Josephine Barnes|Gerard R. Ridgway|Natalie S. Ryan|Elizabeth K. Warrington|Sebastian J. Crutch|Nick C. Fox
Global gray matter changes in posterior cortical atrophy: A serial imaging study
UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London
abstract background posterior cortical atrophy pca neurodegenerative condition predominantly associated alzheimers disease ad pathology crosssectional imaging studies shown different atrophy patterns pca patients compared typical amnestic alzheimers disease tad patients greatest atrophy commonly found posterior regions pca group whereas tad group atrophy prominent medial temporal lobe regions however differential longitudinal atrophy patterns well understood methods study assessed longitudinal changes brain gray matter volumes 17 pca patients 16 tad patients 18 healthy control subjects patient groups symptom durations approximately 5 years results progressive gray matter losses pca tad patients relatively widespread throughout cortex compared control subjects confined areas related initial symptomatology multivariate classification analysis revealed statistically significant group separation pca tad patients 727 accuracy p lt 01 conclusion progression initially focal presentation global pattern suggests different clinical presentations ad might converge pathologically time