Jo-Lâm Vuong, Janina Fett, Alexander Ulbricht, Alexander Ferrauti
Physical determinants, intercorrelations, and relevance of movement speed components in elite junior tennis players
European journal of sport science
previous observational investigations suggest structural diffusion imagingderived phenotypes idps associated major neurodegenerative diseases however whether associations causal remains largely uncertain herein conducted bidirectional twosample mendelian randomization analyses infer causal relationships structural diffusion idps major neurodegenerative diseases using common genetic variantssingle nucleotide polymorphism snps instrumental variables summary statistics genomewide association study gwas structural diffusion idps obtained 33224 individuals uk biobank cohort summary statistics gwas seven major neurodegenerative diseases obtained largest gwas disease date forward mr analyses identified significant suggestively statistical causal effects genetically predicted three structural idps alzheimers disease ad frontotemporal dementia ftd multiple sclerosis example reduction surface area left superior temporal gyrus associated higher risk ad reverse mr analyses identified significantly suggestively statistical causal effects genetically predicted ad lewy body dementia lbd ftd nine structural diffusion idps example lbd associated increased mean diffusivity right superior longitudinal fasciculus ad associated decreased gray matter volume right ventral striatum findings might contribute shedding light prediction therapeutic intervention major neurodegenerative diseases neuroimaging level