Karen R Bottenfield, Maura A Kelley, Shelby Ferebee, Andrew N Best, David Flynn, Theresa A Davies
Effectively teaching cultural competence in a pre-professional healthcare curriculum
BMC medical education
automated peak detection functionalities available commercially accessible software achieving optimal true positive rates frequently necessitates visual inspection manual adjustments initial phase study heterovariants glycoforms monoclonal antibody distinguished using liquid chromatographymass spectrometry revealing discernible peaks intact level comprehensively identify peak heterovariant intactlevel analysis deep learning approach utilizing convolutional neural networks cnns employed subsequent phase study current case study utilizing conventional software peak identification five peaks detected using 05 threshold whereas seven peaks identified using cnn model model exhibited strong performance probability area curve auc 09949 surpassing partial least squares discriminant analysis plsda probability auc 08041 locally weighted regression lwr probability auc 06885 data acquired experimentation realtime auc receiver operating characteristic curve also illustrated superior performance cnn plsda lwr