Ralph Ziegler|David Cavan|Iain Cranston|Katharine Barnard|Jacqueline Ryder|Claudia Vogel|Christopher G. Parkin|W Koehler|Iris Vesper|Bettina Petersen|Matthias Axel Schweitzer|Robin S. Wagner
Use of an Insulin Bolus Advisor Improves Glycemic Control in Multiple Daily Insulin Injection (MDI) Therapy Patients With Suboptimal Glycemic Control
Royal Bournemouth Hospital|Queen Alexandra Hospital|Southampton General Hospital|University of Southampton|Royal Bournemouth Hospital|CS Diagnostics|Roche Pharma AG (Germany)|CS Diagnostics|Roche Pharma AG (Germany)|CS Diagnostics|Roche Pharma AG (Germany)|Roche (United States)
objective use automated bolus advisors associated improved glycemic control patients treated insulin pump therapy conducted study assess impact using insulin bolus advisor embedded blood glucose bg meter glycemic control treatment satisfaction patients treated multiple daily insulin injection mdi therapy study goal achieve ampgt05 a1c reduction patients research design methods 26week prospective randomized controlled multinational study enrolled 218 mditreated patients poorly controlled diabetes 202 type 1 diabetes 16 type 2 diabetes 18 years age older participants mean baseline a1c 89 sd 12 74 mmolmol mean age 424 years sd 140 mean bmi 265 kgm2 sd 42 mean diabetes duration 177 years sd 111 control group cnl patients used standard bg meter manual bolus calculation intervention group exp patients used accuchek aviva expert meter integrated bolus advisor calculate insulin dosages glucose data downloaded used therapy parameter adjustments groups results total 193 patients cnl n 93 exp n 100 completed study significantly exp cnl patients achieved ampgt05 a1c reduction 560 vs 344 p amplt 001 improvement treatment satisfaction diabetes treatment satisfaction questionnaire scale significantly greater exp patients 114 sd 60 vs 90 sd 63 p amplt 001 percentage bg values amplt50 mgdl amplt2 groups study conclusions use automated bolus advisor resulted improved glycemic control treatment satisfaction without increasing severe hypoglycemia