Feng Peng, Ruizhi He, Hebin Wang, Hang Zhang, Min Wang, Tingting Qin, Renyi Qin
Development of a difficulty scoring system for laparoscopic pancreatoduodenectomy in the initial stage of the learning curve: a retrospective cohort study
International journal of surgery (London, England)
acute kidney injury aki common devastating complication hospitalization identified genetic loci associated aki patients hospitalized 20022019 million veteran program data vanderbilt university medical centers biovu aki defined meeting modified kdigo stage1 two consecutive days kidney replacement therapy control individuals required one qualifying hospitalization without aki evidence aki observed hospitalizations genomewide association studies gwas stratified race adjusting sex age baseline estimated glomerular filtration rate egfr top ten principal components ancestry conducted results metaanalyzed using fixed effects models total 54488 patients aki 138051 nonaki individuals included study two novel loci reached genomewide significance metaanalysis rs11642015 near fto locus chromosome 16 obesity traits odds ratio 107 95 confidence interval 105109 rs4859682 near shroom3 locus chromosome 4 glomerular filtration barrier integrity odds ratio 095 95 confidence interval 093096 loci colocalized previous studies kidney function genetic correlation indicated significant shared genetic architecture aki egfr notably association fto locus attenuated adjustment bmi diabetes suggesting association may partially driven obesity fto shroom3 loci showed nominal evidence replication diagnosticcodebased summary statistics uk biobank finngen biobank japan thus large gwa metaanalysis found two loci significantly associated aki suggesting genetics may explain risk aki