Stephen J. Kerr|Thanyawee Puthanakit|Ung Vibol|Linda Aurpibul|S. Vonthanak|Pope Kosalaraksa|Suparat Kanjanavanit|Rawiwan Hansudewechakul|Jurai Wongsawat|Wicharn Luesomboon|Kattiya Ratanadilok|Wasana Prasitsuebsai|Kanchana Pruksakaew|Jasper van der Lugt|Robert Paul|Jintanat Ananworanich|Victor Valcour
Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
UNSW Sydney|HIV Netherlands Australia Thailand Research Collaboration|Chulalongkorn University|HIV Netherlands Australia Thailand Research Collaboration|Cambodia National Malaria Center|Chiang Mai University|National Center for HIV/AIDS, Dermatology and STD|Khon Kaen University|Nakornping Hospital|ChiangRai Prachanukroh Hospital|Bamrasnaradura Infectious Diseases Institute|HIV Netherlands Australia Thailand Research Collaboration|HIV Netherlands Australia Thailand Research Collaboration|Amsterdam Institute for Global Health and Development|HIV Netherlands Australia Thailand Research Collaboration|University of Missouri–St. Louis|Thai Red Cross Society|HIV Netherlands Australia Thailand Research Collaboration|University Memory and Aging Center|University of California, San Francisco
human immunodeficiency virus hivnegative children born hivinfected mothers may exhibit differences neurodevelopment nd compared age gendermatched controls whose lives affected hiv could occur due exposure hiv antiretroviral agents utero perinatally differences environment grow study assessed neurodevelopmental outcomes hivexposed uninfected heu hivunexposed uninfected huu children enrolled controls multicenter nd study thailand cambodia one hundred sixty heu 167 huu children completed neurodevelopmental assessment using beery visual motor integration vmi test color trails perdue pegboard child behavior checklist cbcl thai children n 202 also completed wechsler intelligence scale iq stanfordbinet ii memory tests analyses adjusted caregiver education parent caregiver household income age ethnicity statistically significant lower scores seen verbal iq viq fullscale iq fsiq binet bead memory among heu compared huu mean 95 ci differences 613 103 196 p 0004 457 880 035 p 003 372 657 088 p 001 viq fsiq binet bead memory respectively observed significant differences performance iq binet memory domains color trail perdue pegboard beery vmi cbcl test scores conclude heu children evidence reductions neurodevelopmental outcomes compared huu however differences small remains unclear extent immediate longterm clinical significance