Jonas J. Staudacher|Cemal Yaz?c?|Vadim Bul|Joseph H. Zeidan|Ahmer Khalid|Yinglin Xia|Nancy L. Krett|Barbara Jung
Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer
University of Illinois at Chicago|University of Illinois at Chicago|University of Illinois at Chicago|Carolinas Medical Center|University of Illinois at Chicago|University of Illinois at Chicago|University of Illinois at Chicago|University of Illinois at Chicago
basis overrepresentation colorectal cancer crc africanamerican aa populations compared caucasians multifactorial complex understanding mechanisms racial disparity critical delivery better care several studies investigated sporadic crc differences somatic mutations aas caucasians owing small study sizes conflicting results date definitive conclusions reachedhere present first systematic literature review metaanalysis investigating mutational differences sporadic crc aas caucasians focused frequent driver mutations apctp53 kraspi3ca fbxw7smad4 braf publication inclusion criteria comprised sporadic crc human subjects english language information ethnicity aa caucasian total subject number 20 information mutation frequencieswe identified 6234 publications metaanalysis apc tp54 fbxw7 smad4 possible owing paucity data kras mutations statistically less frequent nonhispanic whites compared aas odds ratio 0640 95 confidence interval ci 0534207666 p00001 mutational differences observed braf pi3ca reach statistical significancehere report mutational patterns kras braf pi3ca sporadic crc aas caucasians systematic metaanalysis previously published data identified increase kras mutations sporadic crc aas may contribute worse prognosis increased mortality crc aas future studies investigating healthcare disparities crc aas control kras mutational frequency