Timothy K Cronin, Cian Ronayne, Niamh O'Donovan, Eimear McGuinness, Katie Cooke, Maeve Dennehy, Colum Dennehy, Derek G Power, Mary R Cahill, Dearbhaile C Collins, Roisin M Connolly, Richard M Bambury, Vitaliy Mykytiv, Michaela J Higgins, Sinéad A Noonan, Seamus O'Reilly
The impact of expanded access programs for systemic anticancer therapy in an Irish cancer centre
Irish journal of medical science
current diagnostic systems alzheimers disease ad rely upon clinical signs symptoms despite fact multiplicity clinical symptoms renders various neuropsychological assessments inadequate reflect underlying pathophysiological mechanisms since putative neuroimaging biomarkers play crucial role understanding etiology ad sought stratify diverse relationships ad biomarkers cognitive decline aging population uncover risk factors contributing diversities ad capitalized large amount neuroimaging data adni study examine inflection points along dynamic relationship cognitive decline trajectories wholebrain neuroimaging biomarkers using stateoftheart statistical model change point detection findings indicated temporal relationship ad biomarkers cognitive decline may differ depending synergistic effect genetic risk biological sex specifically tauopathypet biomarkers exhibit dynamic agedependent association minimental state examination scores p005 inflection points 72 78 83 years old compared amyloidpet neurodegeneration cortical thickness mri biomarkers landscape health disparities ad analysis indicated biological sex moderates rate cognitive decline associated apoe4 genotype meanwhile found higher education levels may moderate effect apoe4 acting marker cognitive reserve