Sarah Dolscheid, Judith Schlenter, Martina Penke
Literacy overrides effects of animacy: A picture-naming study with pre-literate German children and adult speakers of German and Arabic
PloS one
alzheimers disease ad recognized complex severe neurodegenerative disorder presenting significant challenge global health hallmark pathological features include deposition amyloid plaques formation neurofibrillary tangles given context becomes imperative develop early accurate biomarker model ad diagnosis employing machine learning bioinformatics analysis study singlecell data analysis employed identify cellular subtypes exhibited significant differences diseased control groups following identification nk cells hdwgcna analysis cellular communication analysis conducted pinpoint nk cell subset robust communication effects subsequently three machine learning algorithmslasso random forest svmrfewere employed jointly screen nk cell subset modular genes highly associated ad logistic regression diagnostic model designed based characterized genes additionally proteinprotein interaction ppi networks model genes established furthermore unsupervised cluster analysis conducted classify ad subtypes based model genes followed analysis immune infiltration different subtypes finally spearman correlation coefficient analysis utilized explore correlation model genes immune cells well inflammatory factors successfully identified three genes rplp2 rpsa rpl18a exhibit high association ad nomogram based genes provides practical assistance diagnosing predicting patients outcomes interconnected genes screened ppi intricately linked ribosome metabolism covid19 pathway utilizing expression modular genes unsupervised cluster analysis unveiled three distinct ad subtypes particularly noteworthy subtype c3 characterized high expression correlates immune cell infiltration elevated levels inflammatory factors hence inferred establishment immune environment ad patients closely intertwined heightened expression model genes study established valuable diagnostic model ad patients also delved deeply pivotal role model genes shaping immune environment individuals ad findings offer crucial insights early ad diagnosis patient management strategies