Danielle H Rochlin, Nada M Rizk, Babak J Mehrara, Evan Matros, Clifford C Sheckter
Free Flap Reconstruction in the Era of Commercial Price Transparency: What Are We Paying For?
Plastic and reconstructive surgery
objective obesity significant risk factor adverse outcomes following coronavirus infection covid19 however bmi fails capture differences body fat distribution critical driver metabolic health conventional statistical methodologies lack functionality investigate causality fat distribution disease outcomes methods applied bayesian network bn modelling explore mechanistic link body fat deposition hospitalisation risk 459 participants covid19 395 nonhospitalised 64 hospitalised mriderived measures visceral adipose tissue vat subcutaneous adipose tissue sat liver fat included conditional probability queries performed estimate probability hospitalisation fixing value specific network variables results probability hospitalisation 18 higher people living obesity normal weight elevated vat primary determinant obesityrelated risk across bmi categories elevated vat liver fat 10 associated 39 mean increase probability hospitalisation among normal weight reducing liver fat content 10 5 reduced hospitalisation risk 29 conclusion body fat distribution critical determinant covid19 hospitalisation risk bn modelling probabilistic inferences assist understanding mechanistic associations imagingderived phenotypes covid19 hospitalisation risk