Carole E. Aubert|Douglas C. Bauer|Bruno R. da Costa|Martin Feller|Carole Rieben|Eleanor M. Simonsick|Kristine Yaffe|Nicolas Rodondi
The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health <scp>ABC</scp>) Study
University Hospital of Bern|University of Bern|University of California, San Francisco|University of Bern|University Hospital of Bern|University of Bern|University Hospital of Bern|University of Bern|National Institute on Aging|University of California, San Francisco|University Hospital of Bern|University of Bern
summary objective data association subclinical thyroid dysfunction dementia limited conflicting aimed determine whether subclinical thyroid dysfunction associated dementia cognitive decline design populationbased prospective cohort study patients adults aged 7079 years measured thyroid function dementia baseline modified minimental state 3 ms baseline followup measurements primary outcome incidentadjudicated dementia based 3 ms hospital records dementia drugs secondary outcome change 3 ms models adjusted age sex race education baseline 3 ms cardiovascular risk factors results among 2558 adults 85 euthyroid tsh 045449m iu l 2 subclinical hyperthyroidism mildly decreased tsh tsh 010044 iu l 1 subclinical hyperthyroidism suppressed tsh tsh lt 010 iu l normal free thyroxine ft 4 12 subclinical hypothyroidism tsh 4501999 iu l normal ft 4 9 years 22 developed dementia compared euthyroidism risk dementia higher participants subclinical hyperthyroidism suppressed tsh hr 238 95 ci 113504 found significant association mildly decreased tsh hr 079 95 ci 045138 subclinical hypothyroidism hr 091 95 ci 070119 participants subclinical hyperthyroidism suppressed tsh larger decline 3 ms 389 95 ci 762 015 conclusions among older adults subclinical hyperthyroidism tsh lt 010 iu l associated higher risk dementia larger cognitive decline subclinical hyperthyroidism mildly decreased tsh subclinical hypothyroidism