Maher Alsulami, Abdulaziz A Madkhali, Majed T Alharbi, Abdulaziz R Alzahrani, Ibrahim N Aljohani, Majid S Al-Thaqafy, Adnan A Alsulami, Mohamed Eldigre, Saleh Aloraibi
Knowledge and attitude of paediatric first aid among elementary schoolteachers in Jeddah, Saudi Arabia
Journal of family medicine and primary care
bloodbrain barrier bbb prevents neurotoxic plasma components blood cells pathogens entering brain time bbb regulates transport molecules central nervous system cns maintains tightly controlled chemical composition neuronal milieu required proper neuronal functioning review first examine molecular cellular mechanisms underlying establishment bbb focus bbb transport physiology endothelial pericyte transporters perivascular paravascular transport next discuss rare human monogenic neurological disorders primary genetic defect bbbassociated cells demonstrating link bbb breakdown neurodegeneration review effects genes underlying inheritance andor increased susceptibility alzheimers disease ad parkinsons disease pd huntingtons disease amyotrophic lateral sclerosis als bbb relation pathologies neurological deficits next examine bbb dysfunction relates neurological deficits pathologies majority sporadic ad pd als cases multiple sclerosis neurodegenerative disorders acute cns disorders stroke traumatic brain injury spinal cord injury epilepsy lastly discuss bbbbased therapeutic opportunities conclude lessons learned future directions emphasis technological advances investigate bbb functions living human brain molecular cellular level address key unanswered questions