Kyaw Lwin Show, Thae Maung Maung, Aung Pyae Phyo, Kyaw Thet Aung, Chetta Ngamjarus, Nyein Su Aye, Özge Tunçalp, Ana Pilar Betrán, Saw Kler Ku, Pisake Lumbiganon, Khaing Nwe Tin, Nwe Oo Mon, Meghan A Bohren
Feasibility and readiness to implement Robson classification to monitor caesarean sections in public hospitals in Myanmar: Formative research
PLOS global public health
oligonucleotide therapeutics emerged important class drugs offering targeted therapeutic strategies complement traditional modalities monoclonal antibodies small molecules unique ability precisely modulate gene expression makes vital addressing previously undruggable targets critical aspect developing therapies characterizing molecular composition accurately includes determining monoisotopic mass oligonucleotides essential identifying impurities degradants modifications affect drug efficacy safety mass spectrometry ms plays pivotal role process yet accurate interpretation complex mass spectra remains challenging especially large molecules monoisotopic peak often undetectable address issue adapted mind algorithm originally developed topdown proteomics use oligonucleotide data adaptation allows prediction monoisotopic mass readily detectable mostabundant peak mass enhancing ability annotate complex spectra oligonucleotides comprehensive validation modified algorithm silico realworld oligonucleotide data sets demonstrated effectiveness reliability facilitate wider adoption advanced analytical technique encapsulated enhanced mind algorithm userfriendly shiny application online platform simplifies process annotating complex oligonucleotide spectra making advanced mass spectrometry analysis accessible researchers drug developers application available httpsvalkenborglabshinyappsiomind4oligos