Wonseok Oh, Junghyun Jung, Jong Wha J Joo
MR-GGI: accurate inference of gene-gene interactions using Mendelian randomization
BMC bioinformatics
family interventions efficacious relapse prevention schizophrenia multiple different models developed aimed compare efficacy acceptability tolerability family interventions relapse prevention schizophrenia systematic review network metaanalysis searched randomised controlled trials investigated family intervention models aimed preventing relapse patients schizophrenia searched embase medline psycinfo biosis central clinicaltrialsgov international clinical trials registry platform jan 20 2020 pubmed july 15 2021 included blinded openlabel randomised controlled trials least 80 patients schizophrenia spectrum disorders excluded studies patients acutely ill concurrent medical psychiatric disorder prodromal risk psychosis study selection data extraction done two independent reviewers data extracted overall positive negative depressive symptoms schizophrenia quality life adherence overall functioning family burden expressed emotion discontinuations due inefficacy primary outcome relapse measured operationalised criteria psychiatric hospital admissions clinical judgement frequentist randomeffects network metaanalysis calculate odds ratios ors dichotomous outcomes standardised mean differences continuous outcomes 95 cis study protocol registered prospero crd42020169951 identified 28 395 studies database search 334 references previous studies compared 11 family intervention models tested total 90 randomised controlled trials 10 340 participants 3579 females 5632 males sex indicated median age 31 years range 1465 network metaanalysis ethnicity data available interventions exception crisisoriented interventions family psychoeducation two sessions fewer reduced relapse rate significantly compared treatment usual primary timepoint 12 months ors compared treatment usual ranged 018 95 ci 012027 family psychoeducation alone 063 042094 communitybased interventions involving family members results robust various sensitivity subgroup analyses confidence estimates ranged moderate low different comparisons almost family intervention models efficacious preventing relapse schizophrenia family psychoeducation alone without behavioural skills training superior complex models results suggest contexts financial constraints family psychoeducation alone implemented german ministry education research