Theresa Pham, Lisa M D Archibald
Are Children Performing Better on the Digit Span Backward Task Than the Digit Span Forward Task? An Exploratory Analysis
American journal of speech-language pathology
japanese clinical trial jgog3016 showed dosedense weekly paclitaxel combination carboplatin extensively prolonged overall survival os patients advanced ovarian cancer however clinical trials dosedense paclitaxel regimens superior triweekly paclitaxel regimens study causal tree analysis applied explore subpopulations different treatment effects dosedense paclitaxel datadriven approach 587 participants stage iiiv ovarian cancer jgog3016 trial used model development primary endpoint treatment effect terms 3year os patients receiving dosedense vs conventional paclitaxel therapies patients 50 years 3year os similar groups however higher dosedense group patients 50 years dosedense paclitaxel showed strong positive treatment effects patients 50 years stage iiiii disease bmi 23 kgm2 nonccmc residual tumor 1 cm contrast although significant difference os 3year os rate 23 lower dosedense paclitaxel conventional paclitaxel patients 60 years stage iv cancer patients group particularly lower performance status groups causal tree analysis suggested poor prognosis groups represented residual tumor tissue 1 cm benefit dosedense paclitaxel whereas elderly patients advanced disease lowperformance status negatively impacted dosedense paclitaxel subpopulations interest future validation studies personalized treatments based clinical features expected improve advanced ovarian cancer prognosis