Jean L. Richardson|M. Nowicki|Kathleen Danley|Eileen Martin|Mardge H. Cohen|Raúl González|Jasmin Vassileva|Alexandra M. Levine
Neuropsychological functioning in a cohort of HIV- and hepatitis C virus-infected women
University of Illinois at Chicago|Illinois College|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Illinois College|University of Illinois at Chicago|Illinois College|University of Southern California
objective evaluate neurocognitive function 220 women enrolled womens interagency hiv study wihs study disease progression women living hivaids hivnegative controls methods evaluated prevalence abnormal neuropsychological np results hepatitis c virus hcvpositive compared hcvnegative women combination hiv serostatus results np impairment significantly higher hcvpositive women comparison hcvnegative women odds ratio 203 95 confidence interval ci 117351 women coinfected hcv hiv demonstrated greater abnormal np performance infected either particularly evidence cd4 tlymphocyte immunosuppression 200 106 cd4 cellsl 348 95 ci 149815 200 106 cd4 cellsl 538 95 ci 1461984 women hcvpositivehivpositive taking antiretroviral therapy art likely 703 95 ci 2631882 demonstrate np impairment hcvnegativehivnegative analyses controlling separately education intelligence quotient depression sedating drug use head injury ethnicity history substance use hcv continued significantly predict np impairment hcv effect reach significance controlling age bivariate multivariate analyses although odds ratio np abnormalities hcvinfected patients slightly reduced ors 19 testing interaction age infection status conducted agestratified analysis showed significant effect infection status aged 40 years conclusions effect aging coinfected populations require study study demonstrated association hcv risk neurocognitive impairment women living hivaids suggests coinfection additive effect