R Ebner, A Lohse, M P Fabritius, J Rübenthaler, C Wängler, B Wängler, R Schirrmacher, F Völter, H P Schmid, L M Unterrainer, O Öcal, A Hinterberger, C Spitzweg, C J Auernhammer, T Geyer, J Ricke, P Bartenstein, A Holzgreve, F Grawe
Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE
European radiology
experimental studies suggested potential detrimental effects emulsifiers gut microbiota inflammation metabolic perturbations aimed investigate associations exposures food additive emulsifiers risk type 2 diabetes large prospective cohort french adults analysed data 104 139 adults enrolled french nutrinetsant prospective cohort study may 1 2009 april 26 2023 82 456 792 female mean age 427 years sd 145 dietary intakes assessed three 24 h dietary records collected three nonconsecutive days every 6 months exposure additive emulsifiers evaluated multiple food composition databases adhoc laboratory assays associations cumulative timedependent exposures food additive emulsifiers risk type 2 diabetes characterised multivariable proportional hazards cox models adjusted known risk factors nutrinetsant study registered clinicaltrialsgov nct03335644 104 139 participants 1056 diagnosed type 2 diabetes followup mean followup duration 68 years sd 37 intakes following emulsifiers associated increased risk type 2 diabetes total carrageenans hazard ratio hr 103 95 ci 101105 per increment 100 mg per day p00001 carrageenans gum e407 hr 103 101105 per increment 100 mg per day p00001 tripotassium phosphate e340 hr 115 102131 per increment 500 mg per day p0023 acetyl tartaric acid esters monoglycerides diglycerides fatty acids e472e hr 104 100108 per increment 100 mg per day p0042 sodium citrate e331 hr 104 101107 per increment 500 mg per day p00080 guar gum e412 hr 111 106117 per increment 500 mg per day p00001 gum arabic e414 hr 103 101105 per increment 1000 mg per day p0013 xanthan gum e415 hr 108 102114 per increment 500 mg per day p0013 found direct associations risk type 2 diabetes exposures various food additive emulsifiers widely used industrial foods large prospective cohort french adults research needed prompt reevaluation regulations governing use additive emulsifiers food industry better consumer protection european research council french national cancer institute french ministry health idex universit de paris bettencourtschueller foundation