Meghan E. McGarry|John Neuhaus|Dennis W. Nielson|Esteban G. Burchard|Ngoc P. Ly
Pulmonary function disparities exist and persist in Hispanic patients with cystic fibrosis: A longitudinal analysis
University of California, San Francisco|University of California, San Francisco|University of California, San Francisco|University of California, San Francisco|University of California, San Francisco
abstract background hispanic patients cystic fibrosis cf decreased life expectancy compared nonhispanic white patients pulmonary function main predictor life expectancy cf ethnic differences pulmonary function cf understudied objective compare longitudinal pulmonary function hispanic nonhispanic white patients cf methods cohort study 15 018 625 years old patients cf foundation patient registry 2008 2013 compared fev 1 percent predicted longitudinal change fev 1 percent predicted hispanic nonhispanic white patients used linear mixed effects models patientspecific slopes intercepts adjusting 14 demographic clinical variables subanalyses cftr class f508del copies pert use results hispanic patients lower fev 1 percent predicted 799 compared nonhispanic white patients 856 58 95ci 67 48 p lt 0001 however difference fev 1 decline time patients pert larger difference hispanic nonhispanic white patients fev 1 percent predicted patients pert 60 vs 41 p 002 ethnic difference fev 1 percent predicted statistically significant cftr classes class iiii 61 class ivv 59 unclassified 57 p gt 005 f508del copies none 76 heterozygotes 56 homozygotes 53 p gt 005 conclusions disparities pulmonary function exist hispanic patients cf early life persist without improving worsening time valuable investigate factors contributing pulmonary function hispanic patients cf