Bradi B. Granger|Inger Ekman|Christopher B. Granger|Jan Östergren|Bertil Olofsson|Eric L. Michelson|John J.V. McMurray|Salim Yusuf|Marc A. Pfeffer|Karl Swedberg
Adherence to medication according to sex and age in the CHARM programme
Duke University Health System|University of Gothenburg|Duke University Health System|Karolinska University Hospital|AstraZeneca (Sweden)|AstraZeneca (United States)|University of Glasgow|Hamilton Health Sciences|Brigham and Women's Hospital|Harvard University|Sahlgrenska University Hospital|University of Gothenburg
aims although many patients heart failure incomplete adherence prescribed medications predisposing factors remain unclear analysis investigates factors associated adherence particular emphasis age sex methods results multivariable regression analysis 7599 heart failure patients charm trial done evaluate factors associated adherence adherence measured proportion time patients took 80 study medication mean age 66 years sd 11 315 n 2400 women women slightly less adherent men 873 vs 898 p 0002 even adjusted multivariable models treatment p 0006 placebo p 0004 overall p lt 0001 however allcause mortality lower women 215 men 253 adjusted hazard ratio 077 95 ci 069086 p lt 0001 patients low adherence regardless sex higher mortality age severity heart failure number medications smoking status associated adherence conclusion women particularly lt75 years age less likely adherent large sample patients symptomatic heart failure understanding factors associated adherence may provide opportunities intervention