Joy E Lawn|Katarzyna Wilczynska-Ketende|Simon Cousens
Estimating the causes of 4 million neonatal deaths in the year 2000
Save the Children|London International Development Centre|University of London|London School of Hygiene & Tropical Medicine
information causeofdeath lacking 98 worlds 4 million neonatal deaths occur countries inadequate vital registration vr aim estimate country year 2000 distribution neonatal deaths across programmerelevant causes including asphyxia preterm birth congenital abnormalities sepsispneumonia neonatal tetanus diarrhoea othertwo sources neonatal causeofdeath data examined vr datasets countries high coverage 90 published unpublished studies identified systematic searches multinomial regression used model distribution neonatal deaths vrbased model used estimate distribution causes death 37 lowmortality countries without national data studybased model applied obtain estimates 111 highmortality countries uncertainty estimates derived using jackknife approachdata 44 countries vr 96 797 neonatal deaths 56 studies 29 countries 13 685 neonatal deaths met inclusion criteria distribution reported causes death varied substantially countries across studies based 193 countries major causes neonatal death globally estimated infections sepsispneumonia tetanus diarrhoea 35 preterm birth 28 asphyxia 23 regional variation important substantial uncertainty surrounds estimatesthis exercise highlights lack reliable causeofdeath data settings neonatal deaths occur complex statistical models panacea representative data comparable case definitions consistent hierarchical causeofdeath attribution required