Matthew F. Muldoon|Christopher M. Ryan|Lei K. Sheu|Jeffrey Yao|Sarah M. Conklin|Stephen B. Manuck
Serum Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning during Middle Adulthood
University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|VA Pittsburgh Healthcare System|Allegheny College|University of Pittsburgh
existing evidence links greater dietary intake fish n3 pufa better early brain development lowered risk cognitive disorders late life mechanisms associations remain unclear may related specific n3 fatty acids may concern cognitive function generally rather early brain development agerelated cognitive dysfunction investigation tested potential associations n3 fatty acids serum phospholipids major dimensions cognitive functioning midlife adults participants 280 community volunteers 35 54 age free major neuropsychiatric disorders taking fish oil supplements dietary biomarkers alphalinolenic acid ala eicosapentaenoic acid epa docosahexaenonic acid dha serum phospholipids measured using gc five major dimensions cognitive functioning assessed 75min battery neuropsychological tests covariate adjusted regression models higher dha mol related better performance tests nonverbal reasoning mental flexibility working memory vocabulary p 005 associations generally linear associations dha nonverbal reasoning working memory persisted additional adjustment participant education vocabulary scores p 005 neither epa ala notably related 5 tested dimensions cognitive performance among 3 key n3 pufa dha associated major aspects cognitive performance nonpatient adults 55 old findings suggest dha related brain health throughout lifespan may implications clinical trials neuropsychiatric disorders