Zhixin Cyrillus Tan, Anja Lux, Markus Biburger, Prabha Varghese, Stephen Lees, Falk Nimmerjahn, Aaron S Meyer
Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates
bioRxiv : the preprint server for biology
increasing evidence indicates chronic obstructive pulmonary disease copd complex disease involving airflow obstructionairflow obstruction profound effects cardiac function gas exchange systemic consequencesin addition copd results inflammation andor alterations repair mechanisms spillover inflammatory mediators circulation may result important systemic manifestations disease skeletal muscle wasting cachexiasystemic inflammation may also initiate worsen comorbid diseases ischaemic heart disease heart failure osteoporosis normocytic anaemia lung cancer depression diabetescomorbid diseases potentiate morbidity copd leading increased hospitalisations mortality healthcare costscomorbidities complicate management copd need evaluated carefullycurrent therapies comorbid diseases statins peroxisome proliferatoractivated receptoragonists may provide unexpected benefits copd patientstreatment copd inflammation may concomitantly treat systemic inflammation associated comorbiditieshowever new broadspectrum antiinflammatory treatments phosphodiesterase 4 inhibitors significant sideeffects may necessary develop inhaled drugs futureanother approach reversal corticosteroid resistance example effective antioxidantsmore research needed copd comorbidities treatment