Xiao Liang, Oscar O Bautista
Analysis on the difference of college teachers' professional pressure and strategies to improve teachers' mental health under the expectancy theory
Work (Reading, Mass.)
primary sjgren disease psd autoimmune disease characterized lymphoid infiltration exocrine glands leading dryness mucosal surfaces production autoantibodies pathophysiology psd remains elusive treatment demonstrated efficacy available yet better understand biology underlying psd heterogeneity aimed identifying consensus gene modules cms summarize highdimensional transcriptomic data whole blood samples psd patients performed unsupervised gene classification four data sets identified thirteen cms annotated interpreted cms corresponding cell type abundances biological functions using gene set enrichment analyses transcriptomic profiles sorted blood cell subsets correlation independently measured cell type abundances flow cytometry confirmed annotations used cms reconcile previously proposed patient stratifications psd importantly showed expression modules representing lymphocytes erythrocytes treatment initiation associated response hydroxychloroquine leflunomide combination therapy clinical trial consensus modules help identification translation bloodbased predictive biomarkers treatment psd