Kristina Flägel, Marie-Therese Müller, Katja Goetz, Elisabeth Flum, Simon Schwill, Jost Steinhäuser
Bridging the Gap Between Competencies and Uncertainties in Postgraduate Training in Family Medicine: Results and Psychometric Properties of a Self-Assessment Questionnaire
Advances in medical education and practice
ovarian cancer oc major cause cancer mortality women worldwide due occult onset oc nonspecific clinical symptoms early phase lack effective early diagnostic tools oc patients diagnosed advanced stage study shallow wholegenome sequencing utilized characterize fragmentomics features circulating tumor dna ctdna oc patients applying machine learning model multiclass fragmentomics data achieved mean area curve auc 097 95 ci 09620976 diagnosing oc oc scores derived model strongly correlated disease stage comparative analysis oc scores illustrated fragmentomicsbased technology provided additional clinical benefits traditional serum biomarkers cancer antigen 125 ca125 risk ovarian malignancy algorithm roma index conclusion fragmentomics features ctdna potential biomarkers accurate diagnosis oc