S. van Dijk|Wilma Otten|Moniek Zoeteweij|Daniëlle R.M. Timmermans|Christi J. van Asperen|Martijn H. Breuning|Rob A.?E.?M. Tollenaar|J. Kievit
Genetic counselling and the intention to undergo prophylactic mastectomy: effects of a breast cancer risk assessment
Leiden University Medical Center|Leiden University Medical Center|Center for Human Genetics|Leiden University Medical Center|University of Amsterdam|Center for Human Genetics|Leiden University Medical Center|Center for Human Genetics|Leiden University Medical Center|Leiden University Medical Center|Leiden University Medical Center
scientific reports suggest women risk familial breast cancer may benefit prophylactic mastectomy however data available women decide upon clinical option particular role objective risk assessment plays purpose present study assess whether objective risk information provided genetic counselling affects intention prophylactic mastectomy additionally mediating effects breast cancer worry perceived risk investigated total 241 women completed questionnaire receiving information familial lifetime breast cancer risk genetic counselling session path analysis showed objective risk information corrective effect perceived risk 038 p00001 whereas amount breast cancer worry influenced counselling session objective risk information directly affect intention prophylactic mastectomy intention influenced perceived risk counselling 023 p0002 precounselling levels perceived risk 027 p000025 breast cancer worry 032 p00001 higher levels perceived risk breast cancer worry imply stronger intention prophylactic mastectomy personal history breast cancer directly influence intention prophylactic mastectomy affected women undergone mastectomy surgical treatment positively inclined prophylactic mastectomy women breastconserving therapy impact objective risk information intention prophylactic mastectomy limited mediated perceived risk important determinants intention prophylactic mastectomy precounselling levels breast cancer worry perceived risk suggesting genetic counselling one event entire process decision making therefore interventions aimed improving decision making prophylactic mastectomy explicitly address precounselling factors personal beliefs psychological impact family medical history