Wadim Bowl|Knut Stieger|Magdalena Bokun|Silke Schweinfurth|Kerstin Holve|Monika Andrassi-Darida|Birgit Lorenz
OCT-Based Macular Structure–Function Correlation in Dependence on Birth Weight and Gestational Age—the Giessen Long-Term ROP Study
University of Giessen|University of Giessen|University of Giessen|University of Giessen|University of Giessen|University of Giessen|University of Giessen
compare retinal layer thicknesses preterm termborn children using spectraldomain optical coherence tomography sdoct correlate structure retinal functionwe performed sdoct single volume scans foveal region premature children aged 6 13 years without rop norop n 100 spontaneously regressed rop srrop n 50 documented wideangle digital imaging routine screening acute rop 30 agematched termborn children retinal layer segmentation analysis performed custommade software single volumescans using early treatment diabetic retinopathy study gridbased method compared light increment sensitivity lis data obtained microperimeter eccentricity points 0 28 8 previously describedoverall seven children excluded due poor image quality n 1 norop n 2 srrop n 4 term total retina ganglion cell inner plexiform layer gcl outer nuclear layer external limiting membrane onl thickness foveal center norop srrop significantly higher compared term children gestational age ga birth weight bw inversely correlated layer thicknesses rod cone outer segment length differ either group ratio onl whole retina 0 correlated significantly reduced lisincreased thicknesses entire retina specific layers fovea correlate functional loss thinner onl retinae without foveal pit reduced onl ratio potentially caused reduced foveal cone density may first morphologic functional correlate prematurity rop