Chang Hyung Hong|Cherie Falvey|Tamara B. Harris|Eleanor M. Simonsick|Suzanne Satterfield|Luigi Ferrucci|Andrea Metti|Kushang V. Patel|Kristine Yaffe
Anemia and risk of dementia in older adults: Findings from the Health ABC study
San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center|San Francisco VA Medical Center|University of California, San Francisco|Institute on Aging|Ajou University|University of Pittsburgh|University of Washington|University of Tennessee Health Science Center
h3objectiveh3 determine whether anemia associated incident dementia older adults h3methodsh3 studied 2552 older adults mean age 761 years 389 black 518 female participating health aging body composition study free dementia baseline defined anemia using criteria hemoglobin concentration lt13 gdl men lt12 gdl women dementia diagnosis determined dementia medication use hospital records change modified minimental state 3ms score 15 sd mean discrete time cox proportional hazard regression models used examine hazard developing dementia associated anemia h3resultsh3 2552 participants 392 154 older adults anemia baseline 11 years followup 455 178 participants developed dementia unadjusted model baseline anemia increased risk dementia 23 vs 17 hazard ratio 164 95 confidence interval 130 207 compared without anemia association remained significant adjusting demographics iapoei 4 baseline 3ms score comorbidities renal function additional adjustment anemia measures mean corpuscular volume red cell distribution width erythropoietin creactive protein appreciably change results interaction sex race risk developing dementia h3conclusionh3 among older adults anemia associated increased risk developing dementia findings suggest study anemia risk factor dementia target intervention cognitive health warranted