Jasmine Nettiksimmons|Eleanor M. Simonsick|Tamara B. Harris|Suzanne Satterfield|Caterina Rosano|Kristine Yaffe
The Associations between Serum Brain-Derived Neurotrophic Factor, Potential Confounders, and Cognitive Decline: A Longitudinal Study
University of California, San Francisco|National Institute on Aging|National Institute on Aging|University of Tennessee Health Science Center|University of Pittsburgh|San Francisco VA Medical Center|University of California, San Francisco
brainderived neurotrophic factor bdnf plays role maintenance function neurons although persons alzheimers disease lower cortical levels bdnf evidence regarding association circulating bdnf cognitive function conflicting sought determine correlates bdnf level whether bdnf level prospectively associated cognitive decline healthy older adults measured serum bdnf near baseline 912 individuals cognitive status assessed repeatedly modified minimental status examination digit symbol substitution test next 10 years evaluated association bdnf cognitive decline longitudinal models also assessed association bdnf level demographics comorbidities health behaviors found association serum bdnf several characteristics also associated dementia race depression suggesting future studies control potential confounders find evidence longitudinal association serum bdnf subsequent cognitive test trajectories older adults although identify potential trend toward crosssectional association results suggest serum bdnf may limited utility biomarker prospective cognitive decline