Adam Alvenfors, Peter Lingström, Emilia Oskarsson, Cecilia Milton, Jenny Bernson
Finding the person behind caries disease: The dental caregivers' experiences of empowering patients to implement beneficial behavioral changes
Journal of dentistry
circulating tumor cells ctcs tumor cells separate solid tumor enter bloodstream cause metastasis detection enumeration ctcs show promising potential predictor prognosis cancer patients furthermore singlecells sequencing technique provides genetic information individual cells allows classify precisely reliably sequencing data typically comprises thousands gene expression reads per cell artificial intelligence algorithms accurately analyze work presents machinelearningbased classifiers differentiate ctcs peripheral blood mononuclear cells pbmcs based single cell rna sequencing data developed four treebased models trained tested dataset consisting smartseq2 sequenced data primary tumor sections breast cancer patients pbmcs public dataset manually annotated ctc expression profiles 34 metastatic breast patients including triplenegative breast cancer best models achieved 95 balanced accuracy ctc test set per cell basis correctly detecting 133 138 ctcs ctcpbmc clusters considering noninvasive character liquid biopsy examination accurate results conclude work potential application value