Sophie D. Fosså|Milada Cvancarova|Linlin Chen|Annie L. Allan|Jan Oldenburg|Derick R. Peterson|Lois B. Travis
Adverse Prognostic Factors for Testicular Cancer–Specific Survival: A Population-Based Study of 27,948 Patients
University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital|University of Rochester Medical Center|Cancer Registry of Norway|University of Oslo|Oslo University Hospital
purpose prognostic significance age testicular cancer tc diagnosis socioeconomic status ses race marital status tcspecific mortality wellcharacterized cancer curable important identify influence confers increased risk tcspecific mortality patients methods using multivariate causespecific cox regression models accounted competing risks hazard ratios hrs calculated 10year tcspecific mortality among 27948 patients tc reported surveillance epidemiology end results program 1978 2006 independent predictors age diagnosis ses race marital status extent disease eod calendar year diagnosis radiotherapy retroperitoneal lymph node dissection rplnd results compared younger patients diagnostic age 40 associated increased mortality seminoma hr 200 p lt 001 nonseminoma hr 209 p lt 001 evident metastatic disease hr 862 p lt 001 hr 635 p lt 001 respectively unmarried men twoto threefold excess mortality compared married men hr 297 p lt 001 hr 154 p lt 001 respectively among nonseminoma patients decreasing ses p trend lt 001 nonwhite race hr 211 p lt 001 increased mortality diagnosis 1987 resulted reduced mortality compared earlier calendar years hr 058 p 001 hr 074 p 001 respectively lack rplnd associated sevenfold increase death p lt 001 conclusion tcspecific mortality doubled among us patients diagnosed seminoma nonseminoma age 40 even initial treatment eod taken account among men nonseminoma nonwhite race lower ses also significantly increase tcspecific mortality additional research needed enabling development interventional strategies preventive approaches applicable