Kathy S Roberts, Marie Boyle Struble, Christine McCullum-Gomez, Jennifer L Wilkins
Use of a risk communication model to evaluate dietetics professionals' viewpoints on genetically engineered foods and crops
Journal of the American Dietetic Association
probability observed cancer caused radiation exposure usually estimated using cancer rates risk models radioepidemiological cohorts called assigned share definition implicitly assumes ongoing carcinogenic process unaffected studied radiation exposure however strong evidence radiation also accelerate existing clonal development towards cancer work define different association measures observed cancer newly induced accelerated retarded measures quantified exemplarily monte carlo simulations track development individual cells three biologically based twostage clonal expansion tsce models applied first model radiation initiates cancer development two radiation promoting effect ie radiation accelerates clonal expansion precancerous cells parameters tsce models derived breast cancer data atomic bomb survivors hiroshima nagasaki exposure age 30 three models resulted similar estimates age 60 initiation model estimates association nearly identical however promotion models cancerous clonal development frequently accelerated towards younger ages resulting associations substantially higher work shows association given cancer exposure affected person depends underlying biological mechanism substantially larger derived classic radioepidemiology