Hasan Jamal, Abdullah A Marghalani, Ahmed Al-Sharif, Albatool Shinawi, Balgis Gaffar, Ebtsam Abdullah Al-Edaili, Ghaliah Al-Baqami, Mayson AlQarni
Exploring the Perception of Dental Undergraduate Students and Faculty on Environmental Sustainability in Dentistry: A Cross-Sectional Survey in 26 Dental Schools in Saudi Arabia
Dentistry journal
observational realworld study analyze clinical effects alemtuzumab alem subsequent diseasemodifying therapy dmt usage multiple sclerosis ms data retrieved austrian ms treatment registry amstr included baseline bl characteristics alem start annualized relapse rate arr 6month confirmed progression independent relapse activity pira 05point expanded disability status scale edss score increase 6month confirmed disability improvement cdi 05point edss decrease safety outcomes initiation subsequent dmt edss rebaselined 30 days alem start bl edss eightyseven alemtreated patients median age 32 years 72 female 14 treatmentnave followed median 55 interquartile range 3168 months found significant reductions arr 116 alem 015 throughout years 19 p 0001 subsequent dmts initiated 19 patients 22 74 anticd20 monoclonal antibodies year 5 n 53 patients achieved cdi 58 95 confidence interval ci 4571 experienced pira 14 ci 7524 58 remained relapsefree shorter ms duration p 0001 hazard ratio hr 086 ci 080093 previous highefficacy treatment p 0001 hr 516 ci 266100 best predictors cdi pira associated higher number previous dmts p 004 hr 306 ci 105889 found new safety signals alem longlasting beneficial effects arr disability improvement especially initiated early course disease subset patients received subsequent dmts