Allison Poulos, Kylie Wilson, Kelly Ramella
Promoting children's health and well-being through structured recreation during online recess
Health education research
relationship intestinal microbiota arthritis garnered significant attention emerging evidence suggesting potential association dysbiosis various forms inflammatory arthropathies observational studies provided valuable insights microbiota alterations patients arthritis establishing causality remains challenging observational data influenced multiple confounders environmental factors medication effects dietary habits insufficient conclusively determine whether microbiota changes somehow causally linked arthritis heterogeneity results across independent studies complicates interpretation support hypothesis interventional randomised trials deemed necessary yet implementation area presents significant technical limitations experimental animal models offer insights potential pathogenic mechanisms linking dysbiosis arthritis including compromised intestinal barrier function role microbiotaderived metabolites molecular mimicry however conflicting findings underscore complexity hostmicrobiota interactions challenges establishing causalityefforts modulate microbiota arthritis treatment prevention shown promise yet efficacy applicability remains uncertain antibacterial drugs dietary interventions probiotics faecal microbiota transplantation explored clinical utility awaits validation conclusion association intestinal microbiota arthritis increasingly recognised establishing causality remains elusive