Robert B. Devlin|Kelly Duncan|Melanie J. Jardim|Michael Schmitt|Ana G. Rappold|David Díaz-Sánchez
Controlled Exposure of Healthy Young Volunteers to Ozone Causes Cardiovascular Effects
Environmental Protection Agency|Environmental Protection Agency|Environmental Protection Agency|Environmental Protection Agency|Environmental Protection Agency|Environmental Protection Agency
recent epidemiology studies reported associations shortterm ozone exposure mortality studies previously reported associations airborne particulate matter pollution mortality support causal relationship come controlledexposure studies describe pathophysiological mechanisms particulate matter could induce acute mortality contrast ozone almost controlledhumanexposure studies tested whether ozone exposure modulate cardiovascular systemtwentythree young healthy individuals exposed randomized crossover fashion clean air 03ppm ozone 2 hours intermittently exercising blood obtained immediately exposure immediately afterward next morning continuous holter monitoring began immediately exposure continued 24 hours lung function performed immediately immediately exposure bronchoalveolar lavage performed 24 hours exposure immediately ozone exposure observed 989 increase interleukin8 214 decrease plasminogen activator inhibitor1 513 decrease highfrequency component heart rate variability 12 increase qt duration changes interleukin1b plasminogen activator inhibitor1 apparent 24 hours exposure agreement previous studies also observed ozoneinduced drops lung function increase pulmonary inflammationthis controlledhumanexposure study shows ozone cause increase vascular markers inflammation changes markers fibrinolysis markers affect autonomic control heart rate repolarization believe findings provide biological plausibility epidemiology studies associate ozone exposure mortalityurl httpwwwclinicaltrialsgov unique identifier nct01492517