Erin Largo-Wight, Caroline Guardino, Peter S Wludyka, Katrina W Hall, Jeff T Wight, Julie W Merten
Nature contact at school: The impact of an outdoor classroom on children's well-being
International journal of environmental health research
identify injury patterns characteristics associated severe traumatic brain injury course outcome within wellcharacterized cohort may help guide new research treatment initiatives secondary analysis phase 3 randomized controlled trial compared therapeutic hypothermia versus normothermia following severe traumatic brain injury children fifteen sites united states australia new zealand children 18 yr old severe traumatic brain injury baseline clinical ct characteristics patients n 77 examined association mortality outcome measured glasgow outcome scaleextended pediatric revision 3 months traumatic brain injury data presented odds ratios 95 cis demographic clinical ct characteristic associated mortality bivariate analysis characteristics associated worse glasgow outcome scaleextended pediatric revision bivariate analysis two fixed pupils 1417 3385937 abdominal abbreviated injury severity score 203 119349 subarachnoid hemorrhage 336 130870 forward stepwise regression demonstrated abbreviated injury severity spine 348 1141058 midline shift ct 835 1056659 significantly associated mortality number fixed pupils one fixed pupil 347 0791530 two fixed pupils 1361 2896407 hypoxia 522 1022667 subarachnoid hemorrhage 301 101901 independently associated worse glasgow outcome scaleextended pediatric revision following forward stepwise regression severe traumatic brain injury clinically heterogeneous disease accompanied range neurologic impairment variety injury patterns presentation secondary analysis prospectively collected data identifies several characteristics associated outcome among children severe traumatic brain injury future larger trials needed better characterize phenotypes within population