Zoë Lautz, Sibylle Kautz-Freimuth, Arim Shukri, Marcus Redaèlli, Kerstin Rhiem, Rita Schmutzler, Stephanie Stock
Predictors of knowledge and knowledge gain after decision aid use among women with BRCA1/2 pathogenic variants
Patient education and counseling
approximately 5 alzheimers disease patients develop symptoms age 65 earlyonset alzheimers disease either sporadic sporadic earlyonset alzheimers disease dominantly inherited dominantly inherited alzheimers disease presentations sporadic earlyonset alzheimers disease dominantly inherited alzheimers disease characterized brain amyloid accumulation tau tangles hypometabolism neurodegeneration differences topography magnitude pathological changes fully elucidated study directly compared patterns amyloid plaque deposition glucose hypometabolism sporadic earlyonset alzheimers disease dominantly inherited alzheimers disease individuals analysis included 134 symptomatic sporadic earlyonset alzheimers disease amyloidpositron emission tomography petpositive cases university california san francisco alzheimers disease research center mean sd age 597 56 years 89 symptomatic dominantly inherited alzheimers disease cases age 458 93 years 102 cognitively unimpaired nonmutation carriers dominantly inherited alzheimer network study age 449 92 group underwent clinical cognitive examinations 11clabelled pittsburgh compound bpet structural mri 18ffluorodeoxyglucosepet also available participants positron emission tomography scans studies uniformly processed obtain standardized uptake value ratio pib5070 cerebellar grey reference fdg3060 pons reference images statistical analyses included pairwise global voxelwise group comparisons groupindependent component analyses analyses performed also adjusting covariates including age sex minimental state examination apolipoprotein 4 status average composite cortical standardized uptake value ratio compared dominantly inherited alzheimers disease sporadic earlyonset alzheimers disease participants older age onset mean sd 548 82 versus 419 82 cohens 191 years education 164 28 versus 135 32 1 likely apolipoprotein 4 carriers 546 4 versus 281 cramers v 026 similar minimental state examination 206 61 versus 212 74 008 sporadic earlyonset alzheimers disease higher global cortical pittsburgh compound bpet binding mean sd standardized uptake value ratio 192 029 versus 158 044 096 greater global cortical 18ffluorodeoxyglucosepet hypometabolism mean sd standardized uptake value ratio 132 01 versus 139 019 048 compared dominantly inherited alzheimers disease fully adjusted comparisons demonstrated relatively higher pittsburgh compound bpet standardized uptake value ratio medial occipital thalami basal ganglia medialdorsal frontal regions dominantly inherited alzheimers disease versus sporadic earlyonset alzheimers disease sporadic earlyonset alzheimers disease showed relatively greater 18ffluorodeoxyglucosepet hypometabolism alzheimers disease signature temporoparietal regions caudate nuclei whereas dominantly inherited alzheimers disease showed relatively greater hypometabolism frontal white matter pericentral regions independent component analyses largely replicated findings highlighting common unique pittsburgh compound bpet 18ffluorodeoxyglucosepet binding patterns summary findings suggest common distinct patterns amyloid glucose hypometabolism sporadic dominantly inherited earlyonset alzheimers disease