Rui La, Liyu Zhou, Yunfei Yin, Lingchen Lu, Lisong Li, Dinghua Jiang, Lixin Huang, Qian Wu
Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study
BMC women's health
despite rising concerns regarding safety antiobesity medications lack comprehensive pharmacovigilance investigations utilising realworld data aimed characterise prevalence seriousness adverse drug events ades related antiobesity medications identify predictors associated increased risk serious adverse events sae thereby conveying evidence drug safety conducted crosssectional analysis ade cases spontaneously reported korea adverse event reporting system database kidskd ade reports pertaining antiobesity medications prescribed overweight obesity international classification disease 10th revision icd10 code e66 abnormal weight gain icd10 code e635 included analysis performed disproportionality detect association system organ classbased ades seriousness individuals sex estimating reporting odds ratios rors 95 confidence intervals cis performed logistic regression investigate factors substantially associated increased sae risks estimating odds ratio 95 cis common causative antiobesity medication phentermine followed liraglutide ades associated psychiatric disorders ror 1734 95 ci 11112707 liver biliary system disorders ror 22948 95 ci 661370635 cardiovascular disorders ror 5707 95 ci 196516574 respiratory disorders ror 4567 95 ci 177411762 likely serious events additionally men likely experience ades related gastrointestinal disorders ror 1411 less likely heart rhythm disorders ror 0507 risk sae incidences positively correlated male 2196 95 ci 12963721 dual triple combination antiobesity medications 3258 95 ci 16336501 8226 95 ci 304622218 respectively concomitant administration fluoxetine 5236 95 ci 221812365 seriousness antiobesity medicationrelated ades differs among systemorgan class sexrelated differences ade profiles also present predictors substantially increasing risk sae incidences include male higher number concomitant medications including multiple combination antiobesity medications concurrent use fluoxetine nonetheless pharmacovigilance investigation monitoring needed enhance awareness ades induced antiobesity medications