Richard S Liu|Allison E. Aiello|Fiona Mensah|Constantine E Gasser|Kuna Rueb|Billie Cordell|Markus Juonala|Melissa Wake|David Burgner
Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis
University of Melbourne|Murdoch Children's Research Institute|University of North Carolina at Chapel Hill|University of Melbourne|Murdoch Children's Research Institute|Royal Children's Hospital|Royal Ottawa Mental Health Centre|University of Melbourne|Murdoch Children's Research Institute|Murdoch Children's Research Institute|Murdoch Children's Research Institute|Turku University Hospital|University of Turku|University of Melbourne|Murdoch Children's Research Institute|Royal Children's Hospital|Royal Ottawa Mental Health Centre|Australian Regenerative Medicine Institute|Monash University|University of Melbourne|Murdoch Children's Research Institute
inflammation plays central role cardiometabolic disease may represent mechanism linking low socioeconomic status ses early life adverse cardiometabolic health outcomes later life accumulating evidence suggests association childhood ses adult inflammation findings inconsistentwe conducted systematic review metaanalysis observational studies quantify association childhood age 18 years ses inflammatory marker c reactive protein crp adulthood studies identified medline embase databases reviewing bibliographies articles published 1946 december 2015 studyspecific estimates combined metaanalyses using randomeffects models15 21 eligible studies n43 629 ultimately included two separate metaanalyses compared advantaged families participants least advantaged families 25 higher crp levels ratio change geometric mean crp 125 95 ci 119 132 minimally adjusted analyses finding attenuated inclusion adult body mass index bmi adjusted models suggesting bmi strong mediating role crp levelswe observed inverse association childhood ses adulthood crp potentially mediated bmi investigating childhood ses associated childhood bmi crp would provide insight effective timing social clinical interventions prevent cardiometabolic disease