Angela R. Bradbury|Linda Patrick?Miller|Brian L. Egleston|Laura DiGiovanni|Jamie Brower|Diana Harris|Evelyn Stevens|Kara N. Maxwell|Abha Kulkarni|T.A. Vela Chavez|Amanda Brandt|Jessica M. Long|Jacquelyn Powers|Jill Stopfer|Katherine L. Nathanson|Susan M. Domchek
Patient feedback and early outcome data with a novel tiered-binned model for multiplex breast cancer susceptibility testing
University of Pennsylvania|University of Chicago|Cancer Genetics (United States)|Temple University Health System|Fox Chase Cancer Center|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania|University of Pennsylvania
risks benefits utilities multiplex panels breast cancer susceptibility unknown new counseling informed consent models needed sought obtain patient feedback early outcome data novel tieredbinned model multiplex testingbrca12negative untested patients completed pre posttest counseling surveys evaluating testing experiences cognitive affective responses multiplex testingof 73 patients 49 67 completed pretest counseling brca12negative patients likely proceed multiplex testing 86 untested brca12 43 p 001 many patients declining testing reported concern uncertainty distress patients would change anything pre 76 posttest 89 counseling sessions thirtythree patients 72 classified making informed choice including 81 proceeded multiplex testing knowledge increased significantly anxiety depression uncertainty cancer worry significantly increase multiplex testingsome patients particularly without prior brca12 testing decline multiplex testing patients proceeded testing experience negative psychological responses larger studies needed tieredbinned approach innovative genetic counseling informed consent model study era multiplex testinggenet med 18 1 2533