Margaret Bevans|S. Marden|Nancy Kline Leidy|Karen L. Soeken|Georgie Cusack|P. Rivera|Helen Mayberry|Michael Bishop|Richard Childs|A. John Barrett
Health-related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation
National Institute of Nursing Research|National Institutes of Health|National Institute of Nursing Research|National Institutes of Health|University of Maryland, Baltimore|National Institute of Nursing Research|National Institutes of Health|National Institute of Nursing Research|National Institutes of Health|National Institute of Nursing Research|National Institutes of Health|National Cancer Institute|National Heart Lung and Blood Institute|National Heart Lung and Blood Institute
reducedintensity conditioning allogeneic hsct ric less regimenrelated morbidity mortality myeloablative allogeneic hsct mt offering allogeneic transplantation patients otherwise excluded whether advantages improve healthrelated quality life hrql unknown examined hrql effects ric mt patients hematological diseases pretransplant baseline days 0 30 100 1 2 years following hsct hrql measured using short form36 health survey functional assessment cancer therapy general bmt data analyzed using mixed linear modeling adjusting baseline hrql differences patients ric41 mt35 predominately male 67 remissionstable disease 65 eastern cooperative oncology group status or1 97 hrql progressively improved p001 groups higher scores day 100 compared days 0 30 difference groups early recovery 2 years survivors n43 reported hrql similar better baseline results suggest ric mt patients experience similar pattern hrql improvement early recovery twoyear survivors report return baseline better hrql day 100 exception physical health mt patients