Christoph Höchsmann|James L. Dorling|Corby K. Martin|Robert L. Newton|John W. Apolzan|Candice A. Myers|Kara D. Denstel|Emily F. Mire|William D. Johnson|Dachuan Zhang|Connie L. Arnold|Terry C. Davis|Vivian Fonseca|Carl J. Lavie|Eboni G. Price?Haywood|Peter T. Katzmarzyk
Effects of a 2-Year Primary Care Lifestyle Intervention on Cardiometabolic Risk Factors
Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Pennington Biomedical Research Center|Louisiana State University Health Sciences Center Shreveport|Louisiana State University Health Sciences Center Shreveport|Tulane University|Ochsner Health System|Pennington Biomedical Research Center
intensive lifestyle interventions ilis firstline approach effectively treat obesity manage associated cardiometabolic risk factors people access ilis academic health centers primary care must implement similar approaches meaningful effect obesity cardiometabolic disease prevalence date however effective lifestylebased obesity treatment primary care limited examined effectiveness pragmatic ili weight loss delivered primary care among racially diverse lowincome population obesity improving cardiometabolic risk factors 24 monthsthe propel trial promoting successful weight loss primary care louisiana randomly allocated 18 clinics equally usual care ili subsequently enrolled 803 351 usual care 452 ili adults 67 black 84 female obesity participating clinics usual care group continued receive normal primary care ili group received 24month highintensity lifestylebased obesity treatment program embedded clinic setting delivered health coaches weekly sessions initially monthly sessions months 7 24as recently demonstrated participants receiving propel ili lost significantly weight 24 months receiving usual care mean difference 451 95 ci 593 310 p001 fasting glucose decreased ili group compared usual care group 12 months mean difference 71 mgdl 95 ci 120 21 p001 24 months mean difference 08 mgdl 95 ci 62 46 p076 increases highdensity lipoprotein cholesterol greater ili usual care group time points mean difference 24 months 46 mgdl 95 ci 2963 p001 totalhighdensity lipoprotein cholesterol ratio metabolic syndrome severity z score decreased ili group usual care group time points significant mean differences change 031 95 ci 047 014 p001 021 95 ci 036 006 p001 24 months respectively changes total cholesterol lowdensity lipoprotein cholesterol triglycerides blood pressure differ significantly groups time pointa pragmatic ili consistent national guidelines delivered trained health coaches primary care produced clinically relevant improvements cardiometabolic health underserved population 24 months registration url httpswwwclinicaltrialsgov unique identifier nct02561221