Sheelah Mills
The scientific integrity of ADHD: A critical examination of the underpinning theoretical constructs
Frontiers in psychiatry
global measures neuronal activity embrace advantage univariate holistic unique description brain activity reducing spatial dimensions electroencephalography eeg analysis cost lower precision localizing effects work instantaneous radiated power irp proposed new wholebrain descriptor reflecting cortical activity exclusively electromagnetic perspective considering brain consists multiple elementary dipoles wholebrain irp takes account radiational contribution cortical sources unlike conventional eeg analyses evaluate large number scalp source locations irp reflects wholebrain eventrelated measure forces analysis focus single timeseries thus efficiently reducing eeg spatial dimensions multiple comparisons apply developed methodology real eeg data two groups 25 controls vs 30 body dysmorphic disorder bdd patients matched age sex tested prepulse inhibition ppi facilitation ppf paradigm two global brain descriptors extracted betweengroups betweenconditions comparison purposes namely global field power gfp wholebrain irp results showed irp replicate expected condition differences ppf greater ppi responses exhibiting also reduced levels bdd compared control group overall also similar outcomes using gfp irp suggesting consistency two measures finally regression analysis showed ppirelated irp n100 timewindow negatively correlated bdd psychometric scores investigating brain activity irp significantly reduces data dimensionality giving insights global brain synchronization strength conclude irp replicate existing evidence regarding sensorimotor gating effects revealing also group electrophysiological alterations finally electrophysiological irp responses exhibited correlations bdd psychometrics potentially useful supplementary tool bdd symptomatology