Qaiser Suleman, Ishtiaq Hussain, Saqib Shehzad, Makhdoom Ali Syed, Sadaf Ayub Raja
Relationship between perceived occupational stress and psychological well-being among secondary school heads in Khyber Pakhtunkhwa, Pakistan
PloS one
schizophrenia associated widespread cognitive impairments although cognitive deficits one factors strongly associated functional outcome schizophrenia current treatment strategies largely fail ameliorate impairments develop efficient treatment strategies patients schizophrenia better understanding pathogenesis cognitive deficits needed accumulating evidence indicates genetic risk schizophrenia may contribute cognitive dysfunction identify genomic regions jointly influencing schizophrenia cognitive domains reaction time verbalnumerical reasoning well general cognitive function phenotype captures shared variation performance across cognitive domains combining data genomewide association studies multiple phenotypes using conditional false discovery rate analysis provides increased power discover genetic variants could elucidate shared molecular genetic mechanisms data following genomewide association studies published july 24 2014 january 17 2017 combined schizophrenia psychiatric genomics consortium cohort n 79 757 cases 34 486 controls 45 271 verbalnumerical reasoning n 36 035 reaction time n 111 483 uk biobank cohort general cognitive function charge cohorts heart aging research genomic epidemiology n 53 949 cogent cognitive genomics consortium n 27 888 genetic loci identified conditional false discovery rate analysis brain messenger rna expression brain expression quantitative trait locus functionality determined among participants genomewide association studies 21 loci jointly influencing schizophrenia cognitive traits identified 2 loci shared schizophrenia verbalnumerical reasoning 6 loci shared schizophrenia reaction time 14 loci shared schizophrenia general cognitive function one locus shared schizophrenia 2 cognitive traits represented strongest shared signal detected nearest gene tcf20 chromosome 22q132 shared schizophrenia z score 501 p 553 107 general cognitive function z score 443 p 942 106 verbalnumerical reasoning z score 543 p 564 108 18 loci schizophrenia risk alleles associated poorer cognitive performance implicated genes expressed developmental adult human brain replicable expression quantitative trait locus functionality identified 4 loci adult human brain discovered loci improve understanding common genetic basis underlying schizophrenia cognitive function suggesting novel molecular genetic mechanisms