Xiaoxin Yu, Roger S Zoh, David A Fluharty, Luis M Mestre, Danny Valdez, Carmen D Tekwe, Colby J Vorland, Yasaman Jamshidi-Naeini, Sy Han Chiou, Stella T Lartey, David B Allison
Misstatements, misperceptions, and mistakes in controlling for covariates in observational research
eLife
familial adenomatous polyposis fap syndrome near100 lifetime risk colorectal cancer early surveillance prophylactic surgery advocated reduce risk however surveillance practices among fap individuals saudi arabia unknown aimed explore surveillance compliance population well disease impact quality life qol patients fap underwent surgical resection king saud university medical city 2016 2022 included demographic data clinical features family history compliance surveillance collected analyzed qol questionnaires shortform health survey sf36 european organization research treatment eortc conducted phone interview total 14 patients included average age 25 years three patients 214 first family members develop fap nine patients 64 untested genetic mutation due lack referral geneticists compliance rate toward preoperative colonoscopy upper endoscopy 78 however 38 27 compliance rates observed toward initial postoperative colonoscopy respectively compliance rate 14 toward thyroid ultrasound qol scores varied among patients mean score 60 across sf36 domains overall poor compliance observed among participants particularly toward thyroid ultrasound increased health awareness patient education essential addition importance surveillance genetic counseling emphasized among physicians treating patients