Karen L. Kotloff|James A Platts-Mills|Dilruba Nasrin|Anna Roose|William C. Blackwelder|Myron M. Levine
Global burden of diarrheal diseases among children in developing countries: Incidence, etiology, and insights from new molecular diagnostic techniques
University of Maryland, Baltimore|University of Virginia|University of Maryland, Baltimore|University of Maryland, Baltimore|University of Maryland, Baltimore|University of Maryland, Baltimore
global enteric multicenter study gems demonstrated shigella enterotoxigenic escherichia coli etec producing heat stable toxin st either alone combination heat labile toxin among important pathogens associated moderatetosevere diarrhea msd children younger 5years age living developing countries inform design vaccines interventions reviewed published data new results gems characterizing burden shigella stetec infections clinical parameters assessed examine value various case definitions indicators msd associated shigella stetec use clinical trials discussed advantages disadvantages culturebased cultureindependent molecular diagnostics detecting clinically epidemiologically relevant disease shigella serotyping data gems examined identify desirable components shigella etec vaccines likely confer broad protection findings inform development implementation vaccines prevent important infections among infants children developing countries