Pingping Dai, Tongkang Zou, Haiwei Cheng, Zirui Xin, Wei Ouyang, Xiaoqing Peng, Aijing Luo, Wenzhao Xie
Multidimensional analysis of job advertisements for medical record information managers
Frontiers in public health
associations ultraprocessed food upf consumption genetic susceptibility risk osteoarthritis oa remain unknown study examine effect upf consumption genetic susceptibility interactions hipknee oa cohort analyses included 163987 participants uk biobank participants upf consumption derived 24h dietary recall using questionnaire genetic risk scores grss 70 83 single nucleotide polymorphisms snps hip knee oa constructed 1461447 personyears followup 11540 patients developed oa adjustments compared participants low quartile upf consumption high quartile 10 hazard ratio hr 110 95 confidence interval ci 103118 increased risk knee oa significant association found upf consumption hip oa replacing 20 upf diet weight equivalent proportion unprocessed minimally processed food caused 6 hr 094 95 ci 089098 decreased risk knee oa respectively significant interaction found upf consumption genetic predisposition risk knee oa p 001 participants lower oagrs scores experienced higher knee oa risks due upf consumption upf consumption associated higher risk knee oa hip oa particularly lower genetic susceptibility results highlight importance reducing upf consumption prevent knee oa