Timothy Pearman|Jennifer L. Beaumont|Daniel K. Mroczek|M. O'Connor|David Cella
Validity and usefulness of a single?item measure of patient?reported bother from side effects of cancer therapy
Northwestern University|Northwestern University|Northwestern University|Northwestern University|Northwestern University
background improving efficacy cancer treatment resulted increasing array treatmentrelated symptoms associated burdens imposed individuals undergoing aggressive treatment disease often clinical trials compare therapies different types severities adverse effects whether rated clinicians patients difficult know side effect profile disruptive bothersome patients simple summary index bother help adjudicate variability adverse effects across treatments compared methods across 4 studies total 5765 patients enrolled cooperative group studies industrysponsored clinical trials subjects current study patients diagnosed range primary cancer sites including bladder brain breast colonrectum headneck hepatobiliary kidney lung ovary pancreas prostate well leukemia lymphoma patients administered functional assessment cancer therapygeneral version factg single item bothered side effects treatment gp5 rated 5point likert scale part factg determine validity useful summary measure patient perspective correlated individual aggregated clinicianrated adverse events patient reports general ability enjoy life results analyses pharmaceutical trials demonstrated mean gp5 scores bothered side effects treatment significantly differed maximum adverse event grade p lt001 trials clear trend toward increasing gp5 scores level increasing adverse event grade effect sizes ranged 013 046 analyses cooperative group trials demonstrated significant correlation gp5 item gf3 able enjoy life predicted direction conclusions single factg item bothered side effects treatment significantly associated clinicianreported adverse events patients ability enjoy lives promise overall summary measure burden given set treatment toxicities compared another future research identify contribution individual side effects compared one another terms may contribute overall bother cancer 20181249917 2017 american cancer society