Yue Wu, Xixuan Yu, Mengting Li, Jing Zhu, Jun Yue, Yan Wang, Yicun Man, Chao Zhou, Rongsheng Tong, Xingwei Wu
Risk prediction model based on machine learning for predicting miscarriage among pregnant patients with immune abnormalities
Frontiers in pharmacology
following rollout pfizerbiontech bnt162b2 moderna mrna1273 janssen ad26cov2s coronavirus disease 2019 covid19 injections united states millions individuals reported adverse events aes using vaccine adverse events reports system vaers objective analysis describe myocarditis data vaers covid19 vaccines potential determinants myocarditis used vaers data examine frequency reporting myocarditis since beginning mass vaccination campaign compared historical values vaers covid19 vaccine administration data world data database examined myocarditis reports vaers context sex age dose statistical analysis done using students ttest determine statistically significant differences ages among myocarditis adverse events aes chisquare test determine relationships categorical variables statistical significance found number myocarditis reports vaers covid19 vaccination 2021 223 times higher average vaccines combined past 30 years represented 2500 increase absolute number reports first year campaign comparing historical values prior 2021 demographic data revealed myocarditis occurred youths 50 males 69 total 76 cases resulted emergency care hospitalization total myocarditis reports 92 individuals died 3 myocarditis likely dose 2 p 000001 individuals less 30 years age likely individuals older 30 acquire myocarditis p 000001 covid19 vaccination strongly associated serious adverse safety signal myocarditis particularly children young adults resulting hospitalization death investigation underlying mechanisms covid19 vaccineinduced myocarditis imperative create effective mitigation strategies ensure safety covid19 vaccination programs across populations