Alexander W Jung, Peter C Holm, Kumar Gaurav, Jessica Xin Hjaltelin, Davide Placido, Laust Hvas Mortensen, Ewan Birney, S Ren Brunak, Moritz Gerstung
Multi-cancer risk stratification based on national health data: a retrospective modelling and validation study
The Lancet. Digital health
evidence regarding effects particulate matter pm pollutants cardiovascular disease cvd mortality remains limited shanghai china objective thoroughly evaluate associations pm pollutants cvd mortality daily data cvd mortality pm pm10 pm25 pollutants meteorological variables shanghai china gathered 2003 2020 utilized timeseries design generalized additive model assess associations pm pollutants cvd mortality additionally conducted stratified analyses based sex age education seasons using model found pm pollutants significant association cvd mortality study period specifically 029 95ci 014 044 increase cvd mortality every 10 gm3 rise 2day average lag01 concentration pm10 028 95 ci 007 049 increase cvd mortality associated every 10 gm3 rise pm25 concentration lag01 overall estimated effects pm10 pm25 larger warm period compared cold period furthermore males older adult exhibited greater susceptibility pm10 pm25 exposure individuals lower education levels experienced significant effects pm10 pm25 higher education levels findings suggested pm pollutants substantial impact increasing cvd mortality shanghai china moreover impacts air pollution health may altered factors season sex age educational levels