Michelle Lally|Richard C. Goldsworthy|Moussa Sarr|Jessica A. Kahn|Larry K. Brown|Lígia Peralta|Gregory D. Zimet
Evaluation of an Intervention Among Adolescents to Reduce Preventive Misconception in HIV Vaccine Clinical Trials
Lifespan|Brown University|Academic Edge|Westat (United States)|University of Cincinnati Medical Center|Cincinnati Children's Hospital Medical Center|Lifespan|Brown University|University of Maryland, Baltimore|Indiana University – Purdue University Indianapolis
purpose placebo randomization important concepts must understood youth safely participate hiv vaccine studies biomedical trials hiv prevention concepts central phenomenon preventive misconception may associated increase risk behavior among study participants related mistaken beliefs persuasive messaging traditionally used field marketing could enhance educational efforts associated randomized clinical trials methods two educational brochures designed increase knowledge hiv vaccine clinical trials via one twosided persuasive messaging adolescent medicine trials network 120 youth enrolled administered mock hiv vaccine trial consent randomized receive either supplemental information one two brochures results twosided brochure group common clinical trial misconceptions acknowledged refuted significantly higher scores knowledge randomization interpretation side effects consentonly control group willingness participate hiv vaccine trial decreased use brochure conclusion twosided persuasive messaging improves understanding concepts randomization placebo among youth would consider participating hiv vaccine trial evaluation approach considered atrisk youth participating actual trial biomedical intervention hiv prevention