Deija McLean, Katie Eklund, Stephen P Kilgus, Matthew K Burns
Influence of teacher burnout and self-efficacy on teacher-related variance in social-emotional and behavioral screening scores
School psychology (Washington, D.C.)
schizophrenia severe mental illness usually begins late adolescence early adulthood current pharmacological treatments acceptably effective many patients rarely clinically tailored individualized lack sufficient etiopathological knowledge disease together overall comparable effect sizes efficacy available antipsychotics absence clinically actionable biomarkers hindered advance individualized medicine treatment schizophrenia nevertheless degree stratification based clinical markers could guide treatment choices help clinicians move toward individualized psychiatry end panel experts met formally discuss current approach individualized treatment schizophrenia define treatment individualization could help improve clinical outcomes task force seven experts iteratively developed evaluated refined questionnaire items evaluated using delphi method descriptive statistics used summarize rank expert responses expert discussion informed results scoping review personalizing pharmacologic treatment adults adolescents schizophrenia ultimately generated recommendations guide individualized pharmacologic treatment population substantial agreement among expert group members resulting following recommendations 1 individualization treatment requires consideration patients diagnosis clinical presentation comorbidities previous treatment response drug tolerability adherence patterns social factors 2 patient preferences considered shared decisionmaking approach 3 identified barriers personalized care need overcome include lack actionable biomarkers mechanistic similarities available treatments digital tools increasingly used enhance individualized treatment individualized care help provide effective tailored treatments based individuals clinical characteristics disease trajectory family social environment goals preferences