Kimberly A. Yonkers|Errol R. Norwitz|Megan V. Smith|Charles J. Lockwood|Nathan Gotman|Edward Luchansky|Haiqun Lin|Kathleen Belanger
Depression and Serotonin Reuptake Inhibitor Treatment as Risk Factors for Preterm Birth
major depressive disorder use serotonin reuptake inhibitors sris pregnancy associated preterm birth studies attempted separate effects illness treatment inconclusive sought explore separate effects sri use major depressive episodes pregnancy risk preterm birthwe conducted prospective cohort study 2793 pregnant women oversampled recent episode major depression use sri extracted data birth outcomes hospital charts used binary logistic regression model preterm birth 37 weeks gestation used ordered logistic regression model early 34 weeks gestation late 3436 weeks preterm birth used nominal logistic regression model preterm birth antecedents spontaneous preterm laborpreterm premature rupture membranespreterm medical indicationstermuse sri odds ratio 21 95 confidence interval 1046 without 16 1025 major depressive episode associated preterm birth major depressive episode without sri use 12 06821 clear effect preterm birth risk none exposures associated early preterm birth use sris pregnancy associated increases spontaneous medically indicated preterm birthsri use increased risk preterm birth although effect major depressive episode alone unclear symptomatic women undergoing antidepressant treatment elevated risk