Maciej Trzaskowski|Philip S. Dale|Robert Plomin
No Genetic Influence for Childhood Behavior Problems From DNA Analysis
King's College London|King's College London
twin studies behavior problems childhood point substantial genetic influence possible estimate genetic influence using dna alone samples unrelated individuals relying familybased designs twins linear mixed model incorporates dna microarray data confirmed twin results showing substantial genetic influence diverse traits adults present direct comparisons twin dna heritability estimates childhood behavior problems rated parents teachers children themselvesbehavior problem data 2500 ukrepresentative 12yearold twin pairs used twin analyses dna analyses based 1 member twin pair genotype data 17 million dna markers diverse behavior problems assessed including autistic depressive hyperactive symptoms genetic influence dna estimated using genomewide complex trait analysis gcta twin estimates heritability based standard twin model fittingbehavior problems childhoodwhether rated parents teachers children themselvesshow significant genetic influence using gcta even though twin study estimates heritability substantial sample even though gcta twin study estimates genetic influence substantial cognitive anthropometric traitswe suggest new type missing heritability gap gcta twin study estimates behavior problems childhood due nonadditive genetic influence make difficult identify genes responsible heritability