Lauren E Ullrich, John R Ogawa, Michelle D Jones-London
A Retrospective Analysis of Career Outcomes in Neuroscience
eNeuro
background dementia progressive global cognitive impairment syndrome 2010 35 million people worldwide estimated living dementia people mild cognitive impairment mci progress dementia others remain stable recover full function great interest finding good predictors dementia people mci minimental state examination mmse bestknown often used short screening tool providing overall measure cognitive impairment clinical research community settings objectives determine diagnostic accuracy mmse various thresholds detecting individuals baseline mci would clinically convert dementia general alzheimers disease dementia forms dementia followup search methods searched alois cochrane dementia cognitive improvement specialized register diagnostic intervention studies inception may 2014 medline ovidsp 1946 may 2014 embase ovidsp 1980 may 2014 biosis web science inception may 2014 web science core collection including conference proceedings citation index isi web science inception may 2014 psycinfo ovidsp inception may 2014 lilacs bireme 1982 may 2014 also searched specialized sources diagnostic test accuracy studies reviews recently may 2014 medion universities maastricht leuven wwwmediondatabasenl dare database abstracts reviews effects via cochrane library hta database health technology assessment database via cochrane library arif university birmingham uk wwwarifbhamacuk language date restrictions applied electronic searches methodological filters used method restrict search overall maximize sensitivity also checked reference lists relevant studies reviews tracked citations scopus science citation index used searches known relevant studies pubmed track related articles contacted research groups conducting work mmse dementia diagnosis try locate possibly relevant unpublished data selection criteria considered longitudinal studies results mmse administered mci participants baseline obtained reference standard obtained followup time included participants recruited clinically classified individuals mci petersen revised petersen criteria matthews criteria clinical dementia rating 05 used acceptable commonly used reference standards dementia general alzheimers dementia lewy body dementia vascular dementia frontotemporal dementia data collection analysis screened titles generated electronic database searches two review authors independently assessed abstracts potentially relevant studies assessed identified full papers eligibility extracted data create two two tables dementia general dementias two authors independently performed quality assessment using quadas2 tool due high heterogeneity scarcity data derived estimates sensitivity fixed values specificity model fitted produce summary receiver operating characteristic curve main results review included 11 heterogeneous studies total number 1569 mci patients followed conversion dementia four studies assessed role baseline scores mmse conversion mci allcause dementia eight studies assessed test conversion mci alzheimers disease dementia one study provided information mmse conversion mci vascular dementia conversion mci dementia general accuracy baseline mmse scores ranged sensitivities 23 76 specificities 40 94 relationship conversion mci alzheimers disease dementia accuracy baseline mmse scores ranged sensitivities 27 89 specificities 32 90 one study provided information conversion mci vascular dementia presenting sensitivity 36 specificity 80 incidence vascular dementia 62 although planned explore possible sources heterogeneity undertaken due scarcity studies included analysis authors conclusions review find evidence supporting substantial role mmse standalone singleadministration test identification mci patients could develop dementia clinicians could prefer request additional extensive tests sure management patients important aspect assess future updates conversion dementia mci stages could predicted better mmse changes time instead single measurements also important assess set tests rather isolated one may successful predicting conversion mci dementia