Ivo D Dinov, Selvam Palanimalai, Ashwini Khare, Nicolas Christou
Randomization-Based Statistical Inference: A Resampling and Simulation Infrastructure
Teaching statistics
recent data pulsed field ablation pfa atrial fibrillation af ablation suggest progressive reduction procedural times realworld data regarding relationship learning curve pfa clinical outcomes scarce objective evaluate pfa learning curve impact acute outcomes consecutive patients undergoing af ablation farapulse pfa system included prospective nonrandomized multicenter study procedural times stratified operators learning curve comparative analysis skintoskin time conducted radiofrequency rf cryoablation cb pulmonary vein isolation pvi procedures performed operators previous year among 752 patients 351 females 669 paroxysmal af mean age 622 10 years total 625 procedures performed operators 20 pfa procedures time pvi 256 10 min vs 165 8 p 00001 fluoroscopy time 198 8 min vs 159 8 min p 00045 significantly improved 10 associated consistent linear trend towards procedural time reduction r2 092068 across various procedural metrics current pfa skintoskin time lower historical skintoskin one 217 624 procedures similar 112 322 cases higher historical skintoskin one 19 55 major complications reported nationwide multicentric experience novel pfa system proved fast safe acutely effective paroxysmal persistent af patients learning curve appears rapid improvements procedural parameters observed procedures advanced technologies successful ablation af clinical practice athena url httpclinicaltrialsgov identifier nct05617456