Sandra Jahr Svendsen, Ellen Karine Grov, Katrine Staats
Patients' experiences with shared decision-making in home-based palliative care - navigation through major life decisions
BMC palliative care
alzheimers disease common cause dementia causes progressive irreversible deterioration cognition sometimes difficult diagnose leading suboptimal patient care developed predictive model computes multiregional statistical morphofunctional mesoscopic traits t1weighted mri scans without cognitive scores patient biomarker called alzheimers predictive vector apv derived using twostage least absolute shrinkage selection operator lasso apv reliably discriminates people adrp without nadrp alzheimers related pathologies 98 81 accuracy adrp including early form mild cognitive impairment nadrp internal external holdout test sets respectively without priori assumptions need neuroradiology reads new test superior standard hippocampal atrophy 26 accuracy cerebrospinal fluid beta amyloid measure 62 accuracy multiparametric analysis compared dtimri derived fractional anisotropy whose readout neuronal loss agrees adrp phenotype snprs2075650 significantly altered patients adrplike phenotype new data analytic method demonstrates potential increasing accuracy alzheimer diagnosis