Azoukalné Moukénet, Kebfene Moudiné, Ngarkodje Ngarasta, Clement Kerah Hinzoumbe, Ibrahima Seck
Malaria infection and predictor factors among Chadian nomads' children
BMC public health
despite intensive use radiotherapy clinical practice effectiveness depends several factors several studies showed tumour response radiation differs one patient another nonuniform response tumour mainly caused multiple interactions tumour microenvironment healthy cells understand interactions five major biologic concepts called 5 rs emerged concepts include reoxygenation dna damage repair cell cycle redistribution cellular radiosensitivity cellular repopulation study used multiscale model included five rs radiotherapy predict effects radiation tumour growth model oxygen level varied time space radiotherapy given sensitivity cells depending location cell cycle taken account model also considered repair cells giving different probability survival radiation tumour normal cells developed four fractionation protocol schemes used simulated positron emission tomography pet imaging hypoxia tracer 18fflortanidazole 18fhx4 images input data model addition tumour control probability curves simulated result showed evolution tumours normal cells increase cell number radiation seen normal malignant cells proves repopulation included model proposed model predicts tumour response radiation forms basis patientspecific clinical tool related biological data included