Isah Abdulmuminu, Abubakar Mustapha Muhammed, Igboeli Nneka Uchenna, Ibezim Isaac Chijioke, Ibenekwu Chisom Sandra
A CROSS-SECTIONAL ASSESSMENT OF PHARMACISTS' KNOWLEDGE, ATTITUDE AND PRACTICE OF PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HIV IN TWO NIGERIAN TEACHING HOSPITALS
African journal of infectious diseases
organisms evolved variety mechanisms cope unpredictability environmental conditions yet mainstream models metabolic regulation typically based strict optimality principles account uncertainty paper introduces dynamic metabolic modelling framework synthesis recent ideas resource allocation powerful optimal control formulation ramkrishna colleagues particular work extended based hypothesis cellular resources allocated among elementary flux modes according principle maximum entropy concepts generalise unify prior approaches dynamic metabolic modelling establishing smooth interpolation dynamic flux balance analysis dynamic metabolic models without regulation resulting theory successful describing bethedging strategies employed cell populations dealing uncertainty fluctuating environment including heterogenous resource investment accumulation reserves growthlimiting conditions observed behaviour yeast growing batch continuous cultures maximum entropy principle also shown yield optimal control law consistent partitioning resources elementary flux mode families important practical implications model reduction selection simulation