Lori B. Daniels|Paul Clopton|Gail A. Laughlin|Alan S. Maisel|Elizabeth Barrett?Connor
Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults
VA San Diego Healthcare System|VA San Diego Healthcare System|VA San Diego Healthcare System|VA San Diego Healthcare System|VA San Diego Healthcare System
background growthdifferentiation factor15 gdf15 emerging prognostic marker patients cardiovascular disease cvd prognostic value communitydwelling adults reported hypothesized gdf15 would add incremental power prediction mortality population communitydwelling older adults without known heart disease methods results measured plasma gdf15 nterminal probtype natriuretic peptide ntprobnp creactive protein levels 1391 rancho bernardo study participants mean age 70 years history cvd followed mean 11 years models adjusted traditional cvd risk factors gdf15 robust predictor allcause cardiovascular noncardiovascular mortality gdf15 stronger predictor allcause mortality either ntprobnp creactive protein hazard ratio 95 confidence interval per sd log 10 units 15 13 18 p lt00001 gdf15 versus 13 12 15 p lt00001 ntprobnp creactive protein significant predictor among biomarkers considered gdf15 predicted noncardiovascular death hazard ratio 16 14 20 p lt00001 growth differentiation factor15 improved discrimination modestly significantly improved reclassification allcause noncardiovascular mortality borderline improvement cardiovascular mortality ntprobnp significantly improved reclassification allcause cardiovascular mortality creactive protein improve reclassification end point tested participants highest quartile gdf15 ntprobnp increased risk death compared participants ntprobnp elevated hazard ratio 15 11 20 p 001 conclusions growth differentiation factor15 strong predictor allcause cardiovascular noncardiovascular mortality communitydwelling older individuals adding incremental value traditional risk factors ntprobnp creactive protein levels