Lynette Deveaux, Elizabeth Schieber, Lesley Cottrell, Regina Firpo-Triplett, Richard Adderley, Karen MacDonell, Nikkiah Forbes, Bo Wang
Implementing a school-based HIV prevention program during public health emergencies: lessons learned in The Bahamas
Implementation science : IS
risk toxicityrelated dose delays cancer treatment included part pretreatment education considered clinicians upon prescribing chemotherapy objective measure individual risk could influence clinical decisions escalation standard supportive care stratification patients receive proactive toxicity monitoring developed logistic regression prediction model delay7 assess overall risk chemotherapy dose delay 7 days patients receiving firstline treatments breast colorectal diffuse large bcell lymphoma delay7 included hospital treated age start chemotherapy gender ethnicity body mass index cancer diagnosis chemotherapy regimen colony stimulating factor use first cycle dose modifications baseline blood values baseline blood values included neutrophils platelets haemoglobin creatinine bilirubin shrinkage used adjust overoptimism predictor effects internal validation full models development data computed ability models discriminate without poor outcomes cstatistic agreement predicted observed risk calibration slope net benefit used understand risk thresholds model would perform better treat treat none strategies total 4604 patients included study 628 136 incurred 7day delay second cycle chemotherapy delay7 showed good discrimination calibration cstatistic 068 95 confidence interval 06607 following internal validation calibrationinthelarge 0006 delay7 predicts patients individualised risk treatmentrelated delay cycle two treatment score used stratify interventions reduce occurrence treatmentrelated toxicity