Mortadha H Kreeb Al-Dalfi, Shrouk Abdulrazak Hassan Al Ibraheem, Ali Kadhim Qasim Al-Rubaye
The severity of pneumonia and its association with socio-demographic factors among children under five years old in Wasit governorate hospitals, Iraq
Journal of public health in Africa
obesity reached epidemic proportions emphasizing importance reliable biomarkers detecting early metabolic alterations enabling early preventative interventions however understanding molecular mechanisms specific lipid species associated childhood obesity remains limited therefore aim study investigate plasma lipidomic signatures potential biomarkers adolescent obesity total 103 individuals comprising overweightobese n 46 normal weight n 57 randomly chosen baseline orange obesity reduction noncommunicable disease awareness group education cohort followed median 71 years plasma lipidomic profiling performed using uhplchrms method used three different models adjusted clinical covariates analyze data clustering methods used define metabotypes allowed stratification subjects subgroups similar clinical metabolic profiles observed lysophosphatidylcholine lpc species like lpc160 lpc183 lpc181 lpc203 significantly p 005 associated baseline followup bmi adolescent obesity association lpc species bmi remained consistently significant even adjusting potential confounders moreover applying metabotyping using hierarchical clustering provided insights metabolic heterogeneity within normal obese groups distinguishing metabolically healthy individuals unhealthy metabolic profiles specific lpc levels found altered increased childhood obesity particularly followup findings suggest lpc species hold promise potential biomarkers obesity adolescents including healthy unhealthy metabolic profiles