Somayeh Mohammadi, Hamidreza Mokhtarinia, Reza Nejatbakhsh, Andrew Scuffham
Ergonomics evaluation of school bags in Tehran female primary school children
Work (Reading, Mass.)
sensitivity pain varies considerably individuals known heritable increased sensitivity experimental pain risk factor developing chronic pain common debilitating poorly understood symptom understand mechanisms underlying pain sensitivity search rare gene variants maf5 influencing pain sensitivity explored genetic variation individuals responses experimental pain quantitative sensory testing heat pain performed 2500 volunteers twinsuk tuk exome sequencing depth 70 carried dna singletons high low ends heat pain sensitivity distribution two separate subsamples thus tuk1 101 painsensitive 102 paininsensitive examined tuk2 114 96 individuals respectively combination methods used test association rare variants pain sensitivity function genes identified explored using network analysis using causal reasoning analysis genes different patterns snvs pain sensitivity status observed significant enrichment variants genes angiotensin pathway bonferroni corrected p 38104 pathway already implicated animal models human studies pain supporting notion may provide fruitful new targets pain management approach sequencing extreme exome variation normal individuals provided important insights gene networks mediating pain sensitivity humans applicable common complex traits