Maik Bieleke, Thomas Goetz, Takuya Yanagida, Elouise Botes, Anne C Frenzel, Reinhard Pekrun
Measuring emotions in mathematics: the Achievement Emotions Questionnaire-Mathematics (AEQ-M)
ZDM : the international journal on mathematics education
epilepsy genetically complex common brain disorder world affecting millions people almost age groups novel copy number variations cnvs considered important reason numerous neurodevelopmental disorders along intellectual disability epilepsy dna array based studies contribute explain severe clinical presentation disease interoperation many detected cnvs still challenging order study novel cnvs epilepsy related genes saudi family six affected two normal individuals several forms epileptic seizures intellectual disability id minor dysmorphism performed high density whole genome agilent sure print g3 hmn cgh 2x 400 k arraycgh chips analysis results showed de novo deletions duplications deletion plus duplication differential chromosomal regions affected individuals shown normal fathe normal kids using agilent cytogenomics 3066 softwear copy number gain observed chromosome 1 16 22 lce3c hpr gstt2 gsttp2 ddt ddtl genes respectively whereas deletions observed chromosomal regions 8p23p21 43031274337759 potential gene region csmd1 omim 612279 moreover array cgh results deletions duplication also validated using primer design deleted regions utilizing flanked snps using simple pcr also using quantitative real time pcr found de novo deletions duplication study saudi family intellectual disability epilepsy results suggest arraycgh used first line genetic test epilepsy except strong indication monogenic syndrome advanced high put arraycgh technique used study aim collect data base identify new mechanisms describing epileptic disorder may help improve clinical management individual cases decreasing burden epilepsy saudi arabia