Flávia Meneguetti Pieri, Michelle Mosna Touso, Ludmila Barbosa Bandeira Rodrigues, Mellina Yamamura, Ione Carvalho Pinto, Elma Mathias Dessunti, Juliane de Almeida Crispim, Antônio Carlos Vieira Ramos, Luiz Henrique Arroyo, Marcelino Santos Neto, Maria Concebida da Cunha Garcia, Marcela Paschoal Popolin, Tatiane Ramos dos Santos Silveira, Ricardo Alexandre Arcêncio
Patients' perceptions on the performance of a local health system to eliminate leprosy,Paraná State, Brazil
PLoS neglected tropical diseases
transcription target prediction functional genomics data often involves incorporating conjunction complex prior biological knowledge analysis unfortunately typical prior hypotheses qualitative rather quantitative nature many qualitative biological hypotheses decomposed set logic statements binary outcomes present new method convert qualitative statements collection binary statements turn generates partial ordering outcomes tested using semiparametric isotonic regression semiparametric approach yields flexible principled way testing biological hypotheses applied method published arabidopsis microarray dataset identify organ specific transcriptional target genes tested predictions independently using atgenexpress dataset new algorithm performed comparably published approaches allowed rapid analysis complex multiple gene selection criteria