Anne Marie Darling|Chloë R. McDonald|Andrea L. Conroy|Kyla Hayford|W. Conrad Liles|Molin Wang|Said Aboud|Willy Urassa|Kevin C. Kain|Wafaie Fawzi
Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania
Harvard Global Health Institute|University Health Network|University of Toronto|Toronto General Hospital|University of Toronto|Toronto General Hospital|University Health Network|University Health Network|University of Toronto|Toronto General Hospital|University of Washington|Harvard University|Muhimbili University of Health and Allied Sciences|Muhimbili University of Health and Allied Sciences|University Health Network|University of Toronto|Toronto General Hospital|Harvard Global Health Institute|Harvard University
h3objectiveh3 sought investigate relationship panel angiogenic inflammatory biomarkers measured midpregnancy smallforgestationalage sga outcomes subsaharan africa h3study designh3 concentrations 18 angiogenic inflammatory biomarkers determined 432 pregnant women dar es salaam tanzania participated trial examining effect multivitamins pregnancy outcomes infants falling 10th percentile birthweight gestational age relative applied growth standards considered sga multivariate binomial regression models log link function used determine relative risk sga associated increasing quartiles biomarker restricted cubic splines used test nonlinearity associations h3resultsh3 total 60 participants 139 gave birth sga infants compared first quartile risk sga reduced among fourth quartiles vascular endothelial growth factora adjusted risk ratio rr 038 95 confidence interval ci 019074 placental growth factor adjusted rr 028 95 ci 012061 soluble fmslike tyrosine kinase1 adjusted rr 048 95 ci 023101 monocyte chemoattractant protein1 adjusted rr 048 95 ci 025092 leptin adjusted rr 046 95 ci 022096 h3conclusionh3 findings provide evidence altered angiogenic inflammatory mediators midpregnancy women went deliver sga infants