İpek Köse Tosunöz, Sevgi Deniz Doğan
The effect of crossword puzzles on nursing students' learning of concepts related to pain management course: A randomized controlled trial
Nurse education in practice
objective assess whether patients receiving aerobic exercise training performed either home supervised group setting achieve reductions depression comparable standard antidepressant medication sertraline greater reductions depression compared placebo controls methods october 2000 november 2005 performed prospective randomized controlled trial smile study allocation concealment blinded outcome assessment tertiary care teaching hospital total 202 adults 153 women 49 men diagnosed major depression assigned randomly one four conditions supervised exercise group setting homebased exercise antidepressant medication sertraline 50200 mg daily placebo pill 16 weeks patients underwent structured clinical interview depression completed hamilton depression rating scale hamd results 4 months treatment 41 participants achieved remission defined longer meeting criteria major depressive disorder mdd hamd score 8 patients receiving active treatments tended higher remission rates placebo controls supervised exercise 45 homebased exercise 40 medication 47 placebo 31 p 057 treatment groups lower hamd scores treatment scores active treatment groups significantly different placebo group p 23 conclusions efficacy exercise patients seems generally comparable patients receiving antidepressant medication tend better placebo patients mdd placebo response rates high suggesting considerable portion therapeutic response determined patient expectations ongoing symptom monitoring attention nonspecific factors bdi beck depression inventory ci confidence interval hamd hamilton depression rating scale itt intentiontotreat mdd major depressive disorder sd standard deviation ssris selective serotonin reuptake inhibitors tsh thyroid stimulating hormone