Grant Theron|Jonny Peter|Lynn S. Zijenah|Duncan Chanda|Chacha Mangu|Petra Clowes|Andrea Rachow|Maia Lesosky|Michael Höelscher|Alexander S. Pym|Peter Mwaba|Peter R. Mason|Pamela Naidoo|Anil Pooran|Hojoon Sohn|Madhukar Pai|Dan J. Stein|Keertan Dheda
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study
Groote Schuur Hospital|University of Cape Town|Groote Schuur Hospital|University of Cape Town|University of Zimbabwe|University Teaching Hospital|Mbeya University of Science and Technology|Mbeya University of Science and Technology|Mbeya University of Science and Technology|University of Cape Town|Ludwig-Maximilians-Universität München|South African Medical Research Council|Biomedical Research and Training Institute|Human Sciences Research Council|Groote Schuur Hospital|University of Cape Town|McGill University|McGill University|University of Cape Town|Groote Schuur Hospital|University of Cape Town
successful cure tuberculosis tb dependent adherence treatment various factors influence adherence however easily modifiable limited data regarding correlates psychological distress association nonadherence antitb treatment trial new tb test measured psychological distress k10 score tbrelated health literacy morbidity tbscore prior diagnosis 1502 patients symptoms pulmonary tb recruited clinics cape town n 419 harare n 400 lusaka n 400 durban n 200 mbeya n 83 socioeconomic demographic alcohol usagerelated data captured patients initiated treatment dots cards reviewed twoand sixmonths 22 95 ci 20 25 patients severe psychological distress k10 30 multivariable linear regression model increased k10 score independently associated previous tb estimate 95 ci 098009187 p 00304 increased tbscore 1080 120 p 00001 heavy alcohol use 308126 491 p 00010 whereas male gender protective 147228 062 p 00007 26 95 ci 21 32 261 patients cultureconfirmed tb nonadherent multivariable logistic regression model nonadherence reduced tbscore 95 ci 0639 0497 0797 p 00001 health literacy score 07980696 0906 p 00008 increased k10 10821033 1137 p 00012 heavy alcohol usage 14832083 1229 p 00002 independently associated culturepositive patients k10 score 30 morelikely nonadherent 229010335126 p 00416 severe psychological distress frequent amongst tb patients southern africa targeted interventions alleviate psychological distress alcohol use improve health literacy newlydiagnosed tb patients could reduce nonadherence treatment