Kristin Weitzel|Madeline Alexander|Barbara A. Bernhardt|Neil Calman|David J. Carey|Larisa H. Cavallari|Julie R. Field|Diane Hauser|Heather Junkins|Phillip A. Levin|Kenneth D. Levy|Ebony B. Madden|Teri A. Manolio|Jacqueline A. Odgis|Lori A. Orlando|Reed E. Pyeritz|R. Ryanne Wu|Alan R. Shuldiner|Erwin P. Böttinger|Joshua C. Denny|Paul Dexter|David A. Flockhart|Carol R. Horowitz|Julie A. Johnson|Stephen E. Kimmel|Mia Levy|Toni I. Pollin|Geoffrey S. Ginsburg
The IGNITE network: a model for genomic medicine implementation and research
University of Florida|University of Pennsylvania|University of Pennsylvania|Institute for Family Health|Geisinger Health System|University of Florida|Vanderbilt University|Institute for Family Health|National Human Genome Research Institute|National Institutes of Health|Model Clinical Research|Indiana University|National Human Genome Research Institute|National Institutes of Health|National Human Genome Research Institute|National Institutes of Health|National Human Genome Research Institute|National Institutes of Health|Duke Medical Center|University of Pennsylvania|Duke Medical Center|Regeneron (United States)|University of Maryland, Baltimore|Icahn School of Medicine at Mount Sinai|Vanderbilt University|Indiana University|Indiana University|Icahn School of Medicine at Mount Sinai|University of Florida|University of Pennsylvania|Vanderbilt University|University of Maryland, Baltimore|Duke Medical Center
patients clinicians researchers payers seeking understand value using genomic information reflected genotyping sequencing family history data inform clinical decisionmaking however challenges exist widespread clinical implementation genomic medicine prerequisite developing evidence realworld utilityto address challenges national institutes healthfunded ignite implementing genomics practice wwwignitegenomicsorg network comprised six projects coordinating center established 2013 support development investigation dissemination genomic medicine practice models seamlessly integrate genomic data electronic health record deploy tools point care decision making ignite site projects aligned purpose testing models individual projects vary scope design including exploring genetic markers disease risk prediction prevention developing tools using family history data incorporating pharmacogenomic data clinical care refining disease diagnosis using sequencebased mutation discovery creating novel educational approachesthis paper describes ignite network member projects including network structure collaborative initiatives clinical decision support strategies methods return genomic test results educational initiatives patients providers clinical outcomes data individual sites networkwide projects anticipated begin published next yearsthe ignite network innovative series projects pilot demonstrations aiming enhance translation validated actionable genomic information clinical settings develop use measures outcome response genomebased clinical interventions using pragmatic framework provide early data proofs concept utility interventions efforts collaboration stakeholders ignite poised significant impact acceleration genomic information medical practice