Axel Finckh|Glinda S. Cooper|Lori B. Chibnik|Karen H. Costenbader|Julie Watts|Helen Pankey|Patricia A. Fraser|Elizabeth W. Karlson
Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women
Brigham and Women's Hospital|Harvard University|National Institute of Environmental Health Sciences|Brigham and Women's Hospital|Harvard University|Brigham and Women's Hospital|Harvard University|Massachusetts Department of Public Health|Harvard University|Brigham and Women's Hospital|Harvard University|Brigham and Women's Hospital|Harvard University
assess risk systemic lupus erythematosus sle associated occupational exposure silica dust organic solvents urban populationwomen sle identified community screening hospital databases 4 predominantly african american neighborhoods boston female control patients volunteers communities screened absence connective tissue disease demographic factors smoking history detailed occupational history including exposures specific chemicals obtained inperson interviews exposure assessment based independent evaluation occupational history 2 reviewers blinded subjects disease status risks associated exposure silica solvents analyzed using multivariate conditional logistic regression models adjusted potential confoundersninetyfive patients 191 age racematched controls included analysis exposure silica longer 1 year associated sle odds ratio 43 95 confidence interval 95 ci 17112 exposureresponse effect seen longer duration exposures silica p trend 001 association occupational exposure organic solvents sle statistically significant 104 95 ci 03432silica exposure variety industrial occupations urban areas associated increased risk sle longer duration exposure silica dust associated greater risks study provides impetus additional research influence modifiable exposures pathogenesis sle