Yiqi Wangliu, Ji-Kang Chen
The mediating role of coping strategies between caregiving burden and pre-death grief among Chinese adult-child caregivers of dementia patients
Journal of advanced nursing
neuroimaging markers provide quantitative insight brain structure function neurodegenerative diseases alzheimers disease lack mechanistic insights explain pathophysiology mechanisms often mediated genes genetic variations often studied lens genomewide association studies linking two disparate layers ie imaging genetic variation causal relationships biological entities involved diseases etiology would pave way largescale mechanistic reasoning interpretation explore genetic variants may lead functional alterations intermediate molecular traits impact neuroimaging hallmarks series biological processes across multiple scales present approach knowledge pertaining single nucleotide polymorphisms imaging readouts extracted literature encoded biological expression language used novel workflow assist functional interpretation snps clinical context demonstrate approach case scenario proposes kansl1 candidate gene accounts clinically reported correlation incidence genetic variants hippocampal atrophy find workflow prioritizes multiple mechanisms reported literature kansl1 may impact hippocampal atrophy dysregulation cell proliferation synaptic plasticity metabolic processes presented approach enables pinpointing relevant genetic variants well investigating functional role biological processes spanning across several diverse biological scales