Nora Maria Raschle|Bryce L. C. Becker|Sara A. Smith|Lynn Valérie Fehlbaum|Yingying Wang|Nadine Gaab
Investigating the Influences of Language Delay and/or Familial Risk for Dyslexia on Brain Structure in 5-Year-Olds
Boston Children's Hospital|Psychiatry Baselland|Harvard University|Boston Children's Hospital|Boston Children's Hospital|Psychiatry Baselland|Boston Children's Hospital|Harvard University|Boston Children's Hospital
early language delay often associated atypical languageliteracy development neuroimaging studies indicate functional disruptions language print processing schoolage children retrospective report early language delay behavioral data 114 5yearolds retrospective report early language delay infancy n 34 without n 80 familial risk dyslexia without presented behaviorally children retrospective report early language delay exhibited reduced performance languagereadingrelated measures voxelbased morphometry analysis subset n 46 demonstrated association reduced gray matter volume early language delay lefthemispheric middle temporal occipital frontal regions alterations middle temporal cortex children retrospective report early language delay observed regardless familial risk dyslexia additionally children isolated familial risk dyslexia showed gray matter reductions temporoparietal occipitotemporal regions effects profound children risk factors interaction effect early language delay familial risk revealed temporoparietal occipital frontal cortex findings support cumulative effect early behavioral genetic risk factors brain development may ultimately inform diagnosistreatment