Fabio Vinicius Barth, João Pedro Gambetta Polay, Camila Ost
Epidemiological analysis of congenital syphilis in the State of Paraná, Brazil
Revista da Associacao Medica Brasileira (1992)
objective analysis update trends los costs survivorship ecmo use among neonates hypoplastic left heart syndrome hlhs undergoing stage 1 palliation surgery using 2016 data healthcare cost utilization project kids inpatient database identified neonates 28 days old hlhs undergoing stage 1 surgery defined norwood procedure modified blalocktaussig bt shunt sano modification multivariable regression year random effects used compare los costs hospital region case volume survivorship ecmo vs ecmo evalue analysis approach conducting sensitivity analysis unmeasured confounding performed determine unmeasured confounding contributed observed effects significant differences total costs los mortality noted hospital region ecmo use subanalyses case volume however ecmo use mortality maximum evalue confidence interval bound 171 suggesting differences would disappear unmeasured confounder 171 times associated outcome exposure eg socioeconomic factors environment etc findings confirm previous literature demonstrating significant resource utilization among norwood patients particularly undergoing ecmo use based evalue analysis differences hospital region case volume explained moderate unobserved confounding rather reflection quality care provided future analyses surgical quality must account unobserved factors provide meaningful information quality improvement