Prabin Kharibam, Monika Pathania, Manisha Naithani, Yogesh Singh, Yogesh Bahurupi, Minakshi Dhar, Shashi R Yadav, Nitesh Singh
A Comparative Study of Baseline Heart Rate Variability, Sleep Quality, and Oxidative Stress Levels in Hypertensive Versus Normotensive Subjects: A Cross-Sectional Study
Cureus
outcomes children diagnosed cancer improved dramatically past 20 years however although 40 pediatric cancer patients require least one intensive care admission throughout disease course picu outcomes resource utilization population rigorously studied specific group using systematic strategy searched medline embase cinahl databases articles describing picu mortality pediatric cancer patients admitted picu two investigators independently applied eligibility criteria assessed data quality extracted data pooled picu mortality estimates using randomeffects models examined mortality trends time using metaregression models 1218 identified manuscripts 31 studies included covering 16853 picu admissions majority retrospective nature overall pooled weighted mortality 278 95 confidence interval ci 237319 mortality decreased slightly time postoperative patients excluded use mechanical ventilation odds ratio 1849 95 ci 13792478 p 0001 inotropic support 1405 95 ci 9162157 p 0001 continuous renal replacement therapy 324 95 ci 131804 p 001 significantly associated picu mortality picu mortality rates pediatric cancer patients far higher compared current mortality rates general picu population picu mortality remained relatively unchanged past decades slight decrease seen postoperative patients excluded compared infavorably improved mortality seen adults cancer admitted icu researchled improvements led paradigm unlimited aggressive icu management without limitations resuscitations status timelimited trial