Sampsa Kinos, Helga Hagman, Päivi Halonen, Leena-Maija Soveri, Mary O'Reilly, Per Pfeiffer, Jan-Erik Frödin, Halfdan Sorbye, Eetu Heervä, Gabor Liposits, Raija Kallio, Annika Ålgars, Raija Ristamäki, Tapio Salminen, Maarit Bärlund, Carl-Henrik Shah, Ray McDermott, Rebecka Röckert, Petra Flygare, Johannes Kwakman, Arco Teske, Cornelis Punt, Bengt Glimelius, Pia Österlund
Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)
Acta oncologica (Stockholm, Sweden)
century monolayer adsorptions adsorbate molecules adsorbing sites behave ideally successfully described langmuirs adsorption isotherm example amount adsorbed material function concentration material adsorbed obeys langmuirs equation paper argue relation valid macroscopic systems however particle numbers adsorbate molecules andor adsorbing sites small langmuirs model fails describe chemical equilibrium system kinetics forming probability observing occupied sites arises twobody interactions ought include crosscorrelations particle numbers adsorbate adsorbing sites effect correlations reflected deviations predicting composition correlations ignored increases decreasing particle numbers becomes substantial adsorbate molecules adsorbing sites present system addition change augments fraction occupied sites equilibrium eg smaller volume lower temperature stronger adsorption energy increases discrepancy observed properties small systems predicted langmuirs theory contrast large systems crosscorrelations become negligible therefore expressing properties involving twobody processes possible consider independently concentration component applying statistical mechanics concepts derive general expression equilibrium constant adsorption also demonstrated ensembles total numbers particles fixed magnitudes fluctuations particle numbers alone predict average chemical composition system moreover alternative adsorption equation predicting average fraction occupied sites value equilibrium constant proposed derived relations tested results obtained monte carlo simulations