Anna E. Leeuwis|Lorna Smith|Andrew Melbourne|Alun D. Hughes|Marcus Richards|Niels D. Prins|Magdalena Sokolska|David Atkinson|Therese Tillin|Hans Rolf Jäger|Nish Chaturvedi|Wiesje M. van der Flier|Frederik Barkhof
Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
Amsterdam Neuroscience|Amsterdam University Medical Centers|Vrije Universiteit Amsterdam|University College London|University College London|University College London|MRC Unit for Lifelong Health and Ageing|MRC Unit for Lifelong Health and Ageing|University College London|Amsterdam Neuroscience|Amsterdam University Medical Centers|Vrije Universiteit Amsterdam|University College London|University College London|University College London|University College London|University College London|MRC Unit for Lifelong Health and Ageing|Amsterdam Neuroscience|Amsterdam University Medical Centers|Vrije Universiteit Amsterdam|Vrije Universiteit Amsterdam|Amsterdam University Medical Centers|University College London
introduction lower cerebral blood flow cbf associated cardiovascular disease vascular risk factors increasingly acknowledged important contributor cognitive decline dementia crosssectional study examined association cbf cognitive functioning communitybased multiethnic cohort methods sabre southall brent revisited study included 214 european 151 south asian 87 african caribbean participants 71 5 years 39f used 3t pseudocontinuous arterial spin labeling estimate wholebrain hematocrit corrected cbf measured global cognition three cognitive domains memory executive functioningattention language neuropsychological test battery associations investigated using linear regression analyses adjusted demographic variables vascular risk factors mri measures results across groups found association higher cbf better performance executive functioningattention standardized st 011 p 005 stratification ethnicity showed associations higher cbf better performance memory executive functioningattention white european group st 014 p 005 st 018 p 001 respectively associations weaker south asian african caribbean groups conclusions multiethnic communitybased cohort showed modest associations cbf cognitive functioning particular found association higher cbf better performance executive functioningattention memory white european group observations consistent proposed role cerebral hemodynamics cognitive decline