Eric Hoffman, Suzanne Gaglianone, Rahel Ketema, Wangshu Tu, Holly Peay, Paula Clemens, Utkarsh Dang, Laurie Conklin
Return of participant-level clinical trial results to participants: pilot of a simplified centralised approach
BMJ open
clinical practice guidelines cpgs assuming major role medical area grant quality medical assistance supporting physicians evidencebased information interventions treatment single pathologies treatment patients affected multiple diseases comorbid patients one main challenges modern healthcare requires development new methodologies supporting physicians treatment interactions cpgs several approaches started face challenging problem however suffer substantial limitation take account temporal dimension indeed practically speaking interactions occur time instance effects two actions taken different guidelines may potentially conflict practical conflicts happen times execution actions effects overlap time aim devising methodology detect analyse interactions cpgs considers temporal dimension paper first extend previous ontological model deal fact actions goals effects interactions occur time model qualitative quantitative temporal constraints identify different application scenarios propose different types facilities user physicians useful support temporal detection interactions provide modular approach different artificial intelligence temporal reasoning techniques based temporal constraint propagation widely exploited provide users facilities applied methodology two cases comorbidities using simplified versions cpgs propose innovative approach detection analysis interactions cpgs considering different sources temporal information cpgs ontological knowledge execution logs first one literature takes account temporal issues accounts different application scenarios