Yang Song, Jessica Beltran Puerta, Melixa Medina-Aedo, Carlos Canelo-Aybar, Claudia Valli, Marta Ballester, Claudio Rocha, Montserrat León Garcia, Karla Salas-Gama, Chrysoula Kaloteraki, Marilina Santero, Ena Niño de Guzmán, Cristina Spoiala, Pema Gurung, Fabienne Willemen, Iza Cools, Julia Bleeker, Rune Poortvliet, Tajda Laure, Marieke van der Gaag, Kevin Pacheco-Barrios, Jessica Zafra-Tanaka, Dimitris Mavridis, Areti Angeliki Veroniki, Stella Zevgiti, Georgios Seitidis, Pablo Alonso-Coello, Oliver Groene, Ana Isabel González-González, Rosa Sunol, Carola Orrego, Monique Heijmans
Self-Management Interventions for Adults Living with Type II Diabetes to Improve Patient-Important Outcomes: An Evidence Map
Healthcare (Basel, Switzerland)
symptom burden characteristics among survivors pediatric cancers aged 8 18 years remain understudied examine prevalence symptom burden among young childhood cancer survivors identify associations sociodemographic clinical psychological resilience skills healthrelated quality life hrqol crosssectional analysis using data collected november 1 2017 january 31 2019 survivorship clinic usbased comprehensive cancer center conducted participants included 302 dyads children aged 8 18 years survived least 5 years beyond diagnosis primary caregivers data analysis performed march 13 2023 february 29 2024 diagnosis caregiverreported family conflict selfreported caregiver anxiety neighborhoodlevel social vulnerability survivorreported meaning purpose novel symptomlevel burden integrating attributes severity daily activity interference using pediatric version patientreported outcomes version common terminology criteria adverse events global cumulative symptom burden hrqol using euroqol5d multinomial logistic regression identified characteristics associated symptom burden linear regression assessed symptom burden hrqol associations among 302 survivors mean sd age 142 29 years mean sd time since diagnosis 109 29 years 153 507 male 186 620 low 77 257 moderate 37 123 high global cumulative symptom burden greater caregiver anxiety associated moderate risk ratio rr 156 95 ci 109224 global symptom burden greater neighborhood deprivation associated moderate global symptom burden rr 486 95 ci 1291826 survivors greater meaningpurpose less likely moderate rr 042 95 ci 029061 high rr 027 95 ci 016046 global symptom burden burden individual symptoms displayed similar patterns low cohen 060 95 ci 087 032 moderatehigh 098 95 ci 153 043 general pain moderatehigh numbness 099 95 ci 169 029 moderatehigh worry 055 95 ci 099 011 associated lower hrqol crosssectional study young childhood cancer survivors symptom burden prevalent caregiver anxiety disparityrelated neighborhood factors associated greater symptom burden whereas meaning purpose protective factor greater specific symptom burden contributed poorer hrqol findings suggest interventions targeting resilience neighborhood adversity may alleviate symptom burden improve hrqol