Lindsay R. Clark|Rebecca L. Koscik|Christopher R. Nicholas|Ozioma C. Okonkwo|Corinne D. Engelman|Lisa C. Bratzke|Kirk Hogan|Kimberly D. Mueller|Barbara B. Bendlin|Cynthia M. Carlsson|Sanjay Asthana|Mark A. Sager|Bruce P. Hermann|Sterling C. Johnson
Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data
University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center
detecting cognitive decline presymptomatic alzheimers disease ad early mild cognitive impairment mci challenging important treatments targeting adrelated neurodegeneration current study aimed investigate utility performance internally developed robust norms standard norms identifying cognitive impairment late middleage baseline age range 3668 54robust norms developed neuropsychological measures based longitudinally confirmed cognitively normal cn participants n 476 seven hundred seventynine participants enriched ad risk classified psychometric mci pmci cn based standard robust norms singletest versus multitest criteriaprevalence pmci ranged 3 49 depending classification scheme used classified pmci using robust norms exhibited greater subjective cognitive complaints diagnostic stability mild clinical symptoms followupresults suggest identifying early clinically relevant cognitive decline late middleage feasible using robust norms multitest criteria