Lynne M Z Lafave, Joyce Hayek, Alexis D Webster, Ceilidh McConnell
Creating healthy eating and active environments in early learning settings: protocol of the CHEERS eHealth intervention study
Frontiers in nutrition
subjective cognitive decline scd early stage dementia linked alzheimers disease pathology white matter changes found scd using diffusion tensor imaging known limitations voxelwise tensorbased methods fixelbased analysis fba help understand changes white matter fibers relate neurodegenerative proteins multidomain behavior data individuals scd healthy adults normal cognition recruited northeastern taiwan community medicine research cohort 20182022 divided scd normal control nc participants underwent evaluations assess cognitive abilities mental states physical activity levels susceptibility fatigue neurodegenerative proteins measured using immunomagnetic reduction technique multishell diffusion mri data collected analyzed using wholebrain fba comparing results groups correlating multidomain assessments final enrollment included 33 scd 46 nc participants significant differences age sex education groups scd greater fiberbundle crosssection nc pfwe 005 bilateral frontal superior longitudinal fasciculus ii slfii white matter changes correlate negatively plasma a42 level r 038 p 001 positively ad8 score subjective cognitive complaints r 042 p 0004 hamilton anxiety rating scale score degree anxiety hama r 035 p 0019 dimensional analysis fba metrics blood biomarkers found positive correlations plasma neurofilament light chain fiber density splenium corpus callosum pfwe 005 fiberbundle crosssection right thalamus pfwe 005 examination scd grouping interacts correlations fba metrics multidomain assessments showed interactions fiber density corpus callosum letternumber sequencing cognitive score pfwe 001 fatigue leisure activities pfwe 005 based fba investigation suggests white matter structural alterations scd enlargement slfiis fiber crosssection linked plasma a42 neuropsychiatric symptoms suggests potential early axonal dystrophy associated alzheimers pathology scd splenium corpus callosum also critical region axonal degeneration cognitive alteration scd