Mary Ganguli|Vijay Chandra|M. Ilyas Kamboh|Janet M. Johnston|Hiroko H. Dodge|B.K. Thelma|Ramesh C. Juyal|Rajesh Pandav|Steven H. Belle|Steven T. DeKosky
Apolipoprotein E Polymorphism and Alzheimer Disease
apoee4 allele gene apolipoprotein e apoe reported risk factor alzheimer disease ad varying degrees different ethnic groupsto compare apoee4ad epidemiological associations india united states crossnational epidemiological studycasecontrol design within 2 cohort studies using standardized cognitive screening clinical evaluation identify ad dementias polymerase chain reaction identify apoe genotypingrural community samples aged 55 years older n4450 ballabgarh india 70 years older n886 monongahela valley region southwestern pennsylvaniacriteria national institute neurological communicative disorders strokealzheimers disease related disorders association probable possible ad clinical dementia rating cdr scale dementia stagingfrequency apoee4 significantly lower p001 ballabgarh vs monongahela valley 007 vs 011 frequency probable possible ad cdr least 10 indian vs us samples follows aged 55 69 years 01 indian sample aged 70 79 years 07 vs 31 aged 80 years older 40 vs 157 among aged 70 years older adjusted odds ratios 95 confidence interval ad among carriers apoee4 vs noncarriers 34 1293 23 1340 indian us samples respectively significantly different cohorts p 20this first report apoee4 ad indian subcontinent shows low prevalence ad ballabgarh india association apoee4 ad similar strength indian us samples arch neurol 2000