Thomas Scerri|Fahimeh Darki|Dianne F. Newbury|Andrew J. O. Whitehouse|Myriam Peyrard?Janvid|Hans Matsson|Q.W. Ang|Craig E. Pennell|Susan M. Ring|John Stein|Andrew P. Morris|Anthony P. Monaco|Juha Kere|Joel B. Talcott|Torkel Klingberg|Silvia Paracchini
The Dyslexia Candidate Locus on 2p12 Is Associated with General Cognitive Ability and White Matter Structure
Wellcome Centre for Human Genetics|University of Oxford|Karolinska Institutet|Wellcome Centre for Human Genetics|University of Oxford|Telethon Kids Institute|University of Western Australia|Karolinska Institutet|Karolinska Institutet|University of Western Australia|University of Western Australia|University of Bristol|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford|Karolinska Institutet|Folkhälsans Forskningscentrum|University of Helsinki|Science for Life Laboratory|Aston University|Karolinska Institutet|University of St Andrews|Wellcome Centre for Human Genetics|University of Oxford
independent studies shown candidate genes dyslexia specific language impairment sli impact upon readinglanguagespecific traits general population explore effect disorderassociated genes cognitive functions investigated whether play role broader cognitive traits tested panel dyslexia sli genetic risk factors association two measures general cognitive abilities iq verbal nonverbal avon longitudinal study parents children alspac cohort n5000 mrpl19c2orf3 locus showed statistically significant association minimum p 000009 supported independent replications following analysis four cohorts addition fifth independent sample showed association mrpl19c2orf3 locus white matter structure posterior part corpus callosum cingulum connecting large parts cortex parietal occipital temporal lobes findings suggest locus originally identified associated dyslexia likely harbour genetic variants associated general cognitive abilities influencing white matter structure localised neuronal regions