Ji-Yue Li, Xia-Xin Wu, Ya-Ru Fan, Yue-Xian Shi
Valuation of the cultural adaptation and psychometric properties of the Chinese version of the hidden curriculum evaluation scale in nursing education
Nurse education in practice
immunotherapy effective precision medicine treatment several cancers imaging signatures underlying genome radiogenomics glioblastoma patients may serve preoperative biomarkers tumorhost immune apparatus validated biomarkers would potential stratify patients immunotherapy clinical trials trials beneficial facilitate personalized neoadjuvant treatment increased use whole genome sequencing data advances bioinformatics machine learning make developments plausible performed systematic review determine extent development validation immunerelated radiogenomic biomarkers glioblastoma systematic review performed following prisma guidelines using pubmed medline embase databases qualitative analysis performed incorporating quadas 2 tool claim checklist prospero registered crd42022340968 extracted data insufficiently homogenous perform metaanalysis nine studies retrospective included biomarkers extracted magnetic resonance imaging volumes interest included apparent diffusion coefficient values relative cerebral blood volume values imagederived features biomarkers correlated genomic markers tumor cells immune cells patient survival majority studies high risk bias applicability concerns regarding index test performed radiogenomic immune biomarkers potential provide early treatment options patients glioblastoma targeted immunotherapy stratified biomarkers potential allow individualized neoadjuvant precision treatment options clinical trials however prospective studies validating biomarkers interpretation limited due study bias little evidence generalizability