Ian M. Thompson|Catherine M. Tangen|Anthony W. Tolcher|E. David Crawford|Mario A. Eisenberger|CM Moinpour
Association of African-American Ethnic Background With Survival in Men With Metastatic Prostate Cancer
The University of Texas Health Science Center at San Antonio
africanamerican men earlier onset prostate cancer higher prostatespecific antigen psa levels advanced stage diagnosis higher mortality white men known whether poorer survival africanamerican men prostate cancer reflects later stage diagnosis differences basic biology disease evaluate question examined outcomes africanamerican white men metastatic prostate cancer context randomized clinical trialsouthwest oncology group study 8894 randomized phase iii trial compared orchiectomy without flutamide men metastatic prostate cancer using data 288 africanamerican 975 white men trial conducted proportional hazards regression analysis determine ethnicity independent predictor survival statistical tests twosidedafricanamerican men likely white men extensive disease bone pain poorer performance status younger age study entry higher gleason score higher psa levels adjustment prognostic variables hazard ratio hr allcause mortality africanamerican men relative white men 123 p 018 adjustment initial qualityoflife assessments also resulted higher hrs associated africanamerican ethnicity relative white ethnicity hr 139 p 007africanamerican men metastatic prostate cancer statistically significantly worse prognosis white men cannot explained prognostic variables explored study data give increased impetus efforts detect disease early africanamerican men development effective therapies based potential biologic differences ethnic group