Catherine J. Stoodley
Distinct regions of the cerebellum show gray matter decreases in autism, ADHD, and developmental dyslexia
American University
differences cerebellar structure identified autism spectrum disorder asd attention deficit hyperactivity disorder adhd developmental dyslexia however clear different cerebellar regions involved disorder thus whether cerebellar anatomical differences reflect generic developmental vulnerability disorderspecific characteristics clarify conducted anatomic likelihood estimate ale metaanalysis voxelbased morphometry vbm studies compared asd 17 studies adhd 10 studies dyslexic 10 studies participants agematched typicallydeveloping td controls second ale analysis included studies cerebellum region interest roi regions significantly increased gray matter gm cerebellum asd adhd dyslexia data asd studies revealed reduced gm inferior cerebellar vermis lobule ix left lobule viiib right crus adhd significantly decreased gm found bilaterally lobule ix whereas participants developmental dyslexia showed gm decreases left lobule vi overlap cerebellar clusters identified disorder evaluated functional significance regions revealed wholebrain cerebellar roi ale analyses using buckner colleagues 7network functional connectivity map available suit cerebellar atlas cerebellar regions identified asd showed functional connectivity frontoparietal default mode somatomotor limbic networks adhd clusters part dorsal ventral attention networks dyslexia clusters involved ventral attention frontoparietal default mode networks results suggest different cerebellar regions affected asd adhd dyslexia cerebellar regions participate functional networks consistent characteristic symptoms disorder