Kelly Burgoyne, Emma Pagnamenta, Kirstie Hartwell, Vesna Stojanovik
Protocol for a randomised controlled feasibility trial of parent-delivered early language intervention for children with Down syndrome (PACT-DS)
Pilot and feasibility studies
increasing evidence exposure developing brains animals including nonhuman primates commonlyutilized anesthetic agents may cause adverse effects cognition behavior paper summarize methodology populationbased propensitymatched study evaluate possible anesthesiarelated sequelae preschool children evaluated elementary high school cohort children born olmsted county minnesota years 1994 2007 currently local residents identified existing medical records used identify episodes exposure general anesthesia prior age 3 years ie prior 3rd birthday children multiple single anesthesia exposure sampled testing ages 8 12 years 15 19 years period 20122016 match children different exposure groups closely possible sampling guided propensitymatching likelihood receiving anesthesia selected children invited participate single 4hour session neuropsychological testing including national center toxicological researchoperant test battery used study anesthetic neurotoxicity nonhuman primates results testing compared among children different anesthetic exposure histories expected products research detailed phenotype possible anestheticassociated neurotoxicity humans utilizing robust patient database neuropsychological testing battery first comparison effects anesthetic exposure children nonhuman primates performing nearly identical behavioral tasks