Seth Adu?Afarwuah|Anna Lartey|Harriet Okronipa|Per Ashorn|Mamane Zeilani|Janet M Peerson|Mary Arimond|Stephen A. Vosti|Kathryn G. Dewey
Lipid-based nutrient supplement increases the birth size of infants of primiparous women in Ghana
University of Ghana|Tampere University|University of California, Davis|University of Ghana|University of California, Davis|Tampere University|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis|University of Ghana|Tampere University|University of California, Davis
international lipidbased nutrient supplements project developed smallquantity 20 gd lipidbased nutrient supplement lns pregnant lactating womenwe evaluated effects prenatal lns supplementation fetal growthin communitybased partially doubleblind individually randomized controlled trial 1320 women 20 wk pregnant received 60 mg fe400 g folic acid ifa 12 recommended dietary allowances 18 micronutrients including 20 mg fe mmn lns micronutrients mmn group plus 4 minerals macronutrients contributing 118 kcal lns daily delivery fetal growth compared across groups using intentiontotreat analysis primary outcome birth lengththis analysis included 1057 women ifa 349 mmn 354 lns 354 groups differ significantly mean birth length lengthforage z score laz head circumference percentage low birth length differed mean birth weight p 0044 weightforage z score waz p 0046 bmiforage z score bmiz p 0040 trend toward differences low birth weight p 0069 pairwise comparisons lns group greater mean birth weight 85 g p 0040 waz 019 p 0045 bmiz 021 p 0035 lower risk low birth weight rr 061 95 ci 039 096 p 0032 ifa group group differences significant effect intervention modified mothers parity age height baseline hemoglobin household food insecurity child sex parity consistent modifier among primiparous women ifa 131 mmn 110 lns 128 lns group greater mean birth length 091 cm p 0001 laz 047 p 0001 weight 237 g p 0001 waz 056 p 0001 bmiz 052 p 0001 head circumference 050 cm p 0017 head circumferenceforage z score 040 p 0022 ifa group similar differences found comparing lns mmn groups among primiparous women group differences found among multiparous womenprenatal lns supplementation improve fetal growth among vulnerable women ghana particularly primiparous women trial registered clinicaltrialsgov nct00970866