Elizabeth E. Tolley|Polly F. Harrison|Els Goetghebeur|Kathleen M. Morrow|Robert Pool|Doug Taylor|Stephanie N. Tillman|Ariane van der Straten
Adherence and its Measurement in Phase 2/3 Microbicide Trials
Family Health International 360|International Partnership for Microbicides|Ghent University Hospital|Miriam Hospital|Brown University|Barcelona Centre for International Affairs|Family Health International 360|International Partnership for Microbicides|RTI International
adherence optimization measurement emerged critically challenging issues clinical trials topical microbicides although microbicide trials routinely collected adherence data utilization trial design implementation interpretation inconsistent drawing datadriven presentations several focused meetings paper synthesizes lessons past microbicide trials provides recommendations future trials microbicide hiv prevention technologies first describes four purposes adherence data collection particular attention intentiontotreat versus adherenceadjusted analyses determining effectiveness second microbicide fields experiences adherence measures data collection modes discussed including strengths weaknesses various options approaches improving measurement several approaches optimizing trial participants adherence presented paper concludes set recommendations immediate use research