Sasha Tregenza, Verity Campbell-Barr
Quality early childhood education and care in a time of COVID-19
Journal of early childhood research : ECR
haematopoietic stem cell transplantation hsct potentially curative treatment sickle cell anaemia sca hsct offers possibility disease remission also lead longterm complications including gonadal dysfunction premature menopause conducted retrospective cohort study female survivors hydroxyurea therapy underwent posthsct followup sca teaching hospital lagos nigeria january 2019 december 2022 participants eligible least five years posthsct hydroxyurea treatment available serum samples markers ovarian function measurement demographic clinical data collected hospital register patients medical records serum levels oestradiol luteinizing hormone lh folliclestimulating hormone fsh antimllerian hormone amh measured using abbott architect i1000sr chemiluminescent immunoassay analyzer abbott diagnostics abbott park il descriptive statistics inferential analyses used assess relationship markers ovarian function fsh amh clinical parameters statistically significant differences median serum levels assessed endocrine hormones hsct nonhsct hydroxyurea groups sca survivors 826 sca survivors experienced ovarian dysfunction hsct treatment impaired ovarian function sca survivors associated longer median followup duration sca survivors normal ovarian function 120 vs 75 years p 0048 higher odds impaired ovarian function sca survivors myeloablative regimens reduced intensity conditioning regimens 941 vs 500 p 0040 study highlights significant impact hsct longterm ovarian function female sca survivors however prospective studies larger sample sizes longer followup periods required confirm findings elucidate factors influencing ovarian function sca survivors hsct addition studies also needed elucidate optimal transplant protocols fertility preservation strategies minimize gonadal toxicity preserve reproductive potential female sca patients undergoing hsct