Bruce Doré, Leonard Ort, Ofir Braverman, Kevin N Ochsner
Sadness shifts to anxiety over time and distance from the national tragedy in Newtown, Connecticut
Psychological science
topologically associating domains tads megabasescale features chromatin spatial architecture organized domainwithindomain tad hierarchy within tads inner smaller subtads manifest celltocell variability also precisely regulate transcription differentiation although 20 tad callers able detect tad usability biomedicine confined disagreement outputs limit understanding tad hierarchy compare 13 computational tools across various conditions develop metric evaluate similarity tad hierarchy although outputs tad hierarchy level vary among callers data resolutions sequencing depths matrices normalization consistent higher similarity larger tads present comprehensive benchmarking tad hierarchy callers operational guidance researchers life science researchers moreover simulating mixing different types cells confirm tad hierarchy generated simply stacking hic heatmaps heterogeneous cells finally propose air conditioner model decipher role tad hierarchy transcription