Jessie King, Barnaby Kelly, Nayla Rhein, Rhonda Rosengren
Post-COVID-19 approach to teaching an undergraduate laboratory class focused on experimental design and data interpretation
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
genetic discoveries human brain development neuropsychiatric syndromes changed landscape psychiatric research genotyping hundreds thousands individuals identified many hundreds genomic regions associated psychiatric diagnoses progress made uncovering specific genes underlie statistical associations although still undetermined great expectations genetic discoveries lead novel treatments based fundamental mechanisms illness important caveats individual riskassociated common variants explain tiny fraction individual liability degree common risk variants represent core pathogenic insights controversial individuals rare penetrant risk variants often intellectually disabled raises epistemological questions classification clinical research application polygenic risk scoresthe cumulative sum associated alleles individual genometo prediction models environmental influences outcome gaining enthusiasm scores explain liability predictions small yet actionable individuals psychiatry intertwined genomic medicine understanding call schizophrenia possibilities improving lives affected individuals never seemed promising yet research challenges daunting psychiatric syndromes ultimately reflect brain mishandles environmental information systems level far downstream effect genes cells