Rebecca J. Schmidt|Ana?Maria Iosif|Elizabeth Guerrero Angel|Sally Ozonoff
Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings
University of California, Davis|University of California, Davis|University of California, Davis|University of California, Davis
maternal use folic acid supplements inconsistently associated reduced risk autism spectrum disorder asd child study date examined association context asd recurrence highrisk familiesto examine association maternal prenatal vitamin use asd recurrence risk younger siblings children asdthis prospective cohort study analyzed data sample children n 332 mothers n 305 enrolled marbles markers autism risk babies learning early signs study participants marbles study recruited mind institute university california davis primarily families receiving services children asd california department developmental services sample younger siblings high risk asd born december 1 2006 june 30 2015 completed final clinical assessment within 6 months third birthday prenatal vitamin use pregnancy reported mothers telephone interviews data analysis study conducted january 1 2017 december 3 2018autism spectrum disorder nontypical development nontd typical development td algorithmically defined according autism diagnostic observation schedule mullen scales early learning subscale scoresafter exclusions final sample comprised 241 younger siblings 140 581 male 101 419 female mean sd age 365 16 months mothers 231 959 reported taking prenatal vitamins pregnancy 87 mothers 361 met recommendations take prenatal vitamins 6 months pregnancy prevalence asd 141 18 children whose mothers took prenatal vitamins first month pregnancy compared 327 37 children whose mothers take prenatal vitamins time children whose mothers reported taking prenatal vitamins first month pregnancy less likely receive asd diagnosis adjusted relative risk rr 050 95 ci 030081 nontd 36month outcome adjusted rr 114 95 ci 075175 compared children whose mothers reported taking prenatal vitamins children former maternal prenatal vitamin group also statistically significantly lower autism symptom severity adjusted estimated difference 060 95 ci 097 023 higher cognitive scores adjusted estimated difference 71 95 ci 12131maternal prenatal vitamin intake first month pregnancy may reduce asd recurrence siblings children asd highrisk families additional research needed confirm results investigate dose thresholds contributing nutrients biologic mechanisms prenatal vitamins inform public health recommendations asd prevention affected families