Anne F Weidinger, Ricarda Steinmayr, Birgit Spinath
Ability self-concept formation in elementary school: No dimensional comparison effects across time
Developmental psychology
sarscov2 infection considered relapsing inflammatory process dysregulation il6 signalling classic il6 signalling thought represent defence mechanism pathogens contrast il6 transsignalling proinflammatory effects severe covid19 therapeutic strategies focused global inhibition il6 controversial results hypothesized specific blockade il6 transsignalling could inhibit inflammatory response preserving host defence activity inherent il6 classic signalling test role specific il6 transsignalling inhibition sgp130fc short longterm consequences covid19 used established k18hace2 transgenic mouse model histological well immunohistochemical analysis proinflammatory marker profiling performed investigate il6 transsignalling human cells used primary lung microvascular endothelial cells fibroblasts presenceabsence sgp130fc report targeting il6 transsignalling sgp130fc attenuated sarscov2related clinical symptoms mortality surviving mice treatment caused significant decrease lung damage vitro il6 transsignalling induced strong persisting jak1stat3 activation endothelial cells lung fibroblasts proinflammatory effects attenuated sgp130fc data also suggest cells scant amounts il6r induction gp130 il6 il6sil6r complex sustains il6 transsignalling il6 transsignalling fosters progression covid19 suggests specific blockade signalling mode could offer promising alternative mitigate short longterm consequences without affecting beneficial effects il6 classic signalling results implications development new therapies lung injury endotheliopathy covid19 project supported isciii spain cov2000792 mb pi2301351 marh european commissionnext generation eu european union regulation eu 20202094 csics global health platform pti salud global sgl2103029 mb pid2019110587rbi00 mb supported micinaei1013039501100011033and pid2022143034obi00 mb micinaei1013039501100011033feder marh acknowledges support isciii spain european commissionnext generation eu european union csics global health pti