Nairn Scobie, Michael Duncan, Jennifer Gillespie, Neil Russell
Use of Lt Systems in Large Class Lab Delivery
Advances in experimental medicine and biology
compare fundus autofluorescence faf spectral domainoptical coherence tomography oct measurements geographic atrophy ga area analyze lesion area changes measured sdoct gather1 assessment reliability analysis using prospective randomized doublemasked phase 23 clinical trial data gather1 examined efficacy safety avacincaptad pegol acp ga treatment post hoc analysis performed identify correlations faf octbased measurements ga ga area measured bluelight faf images using semiautomatic segmentation software support oct near infrared imaging machinelearning enhanced multilayer segmentation oct scans reviewed human readers segmentation errors corrected needed ga area defined total rpe loss crosssectional b scans time points included months 0 6 12 18 additionally octbased gaarea changes acp sham analyzed strong correlation r093 faf oct ga area measurements persisted 18 months mean sd differences oct faf ga measurements negligeable 011 mm2 142 month 0 003 mm2 162 month 6 017 mm2 181 month 12 007 mm2 178 month 18 oct assessments ga growth revealed 30 27 reduction months 12 18 respectively acp sham replicating faf measurements gather1 strong correlation blue faf oct measurements ga area supports oct reliable method measure ga lesion area clinical trials