Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P Worth, Olivier Fardel
Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives
Environment international
intervention effects observed efficacy trials rarely replicated interventions broadly disseminated underscoring need information factors influencing reallife implementation program impact using data ongoing national implementation evidencebased hiv prevention program focus youth caribbean foyc bahamas study examines factors influencing teachers patterns implementation impact teachers initial implementation foyc subsequent delivery booster sessions students outcomes data collected 80 government elementary 34 middle schools 2011 2014 involving 208 grade 6 75 grade 7 58 grade 8 teachers 4411 students initially grade 6 followed 3 years student outcomes include hivaids knowledge reproductive health skills selfefficacy intention use protection data teachers includes implementation modification curriculum attitudes towards prevention program comfort level curriculum attendance training workshops structural equation modeling mixedeffect modeling analyses applied examine impact teachers implementation teachers attitudes towards comfort intervention curriculum attendance curriculum training workshop direct effect teachers patterns implementation direct effect student outcomes teachers attitudes direct positive effect student outcomes teachers training interactive teaching methods longer duration teachers positively associated teachers comfort curriculum highquality implementation grade 6 significantly related student outcomes grades 6 7 postimplementation level implementation booster sessions grades 7 8 likewise significantly related subsequent student outcomes grades highquality initial implementation prevention program significantly related better program outcomes poor subsequent delivery booster sessions undermine positive effects initial implementation strong subsequent delivery booster sessions partially overcome poor initial implementation