Jenna Gettings, Michaila Czarnik, Elana Morris, Elizabeth Haller, Angela M Thompson-Paul, Catherine Rasberry, Tatiana M Lanzieri, Jennifer Smith-Grant, Tiffiany Michelle Aholou, Ebony Thomas, Cherie Drenzek, Duncan MacKellar
Mask Use and Ventilation Improvements to Reduce COVID-19 Incidence in Elementary Schools - Georgia, November 16-December 11, 2020
MMWR. Morbidity and mortality weekly report
use extracorporeal membrane oxygenation ecmo pediatric patients underlying malignancies remains controversial however era survival rates children malignancies increased significantly several recent reports demonstrated effective ecmo use children cancer aimed estimate outcome complications ecmo treatment children searched medline embase cinahl databases studies use ecmo pediatric patients underlying malignancy inception september 2020 review conducted adherence preferred reporting items systematic review metaanalysis statement study eligibility independently assessed two authors disagreements resolved third author included studies evaluated quality using newcastleottawa scale nos random effects metaanalyses dersimonian laird performed primary outcomes mortality ecmo hospital mortality thirteen retrospective observational cohort studies included moderate quality 625 patients commonest indication ecmo severe respiratory failure 92 pooled mortality ecmo 55 95 confidence interval ci 4763 pooled hospital mortality 60 95 ci 5467 although heterogeneity among included studies low confidence intervals large addition majority data derived registries overlapping patients excluded metaanalyses prevent resampling participants across included studies finally lack consistent complications reporting among studies significantly higher mortalities general picu patients reported use ecmo children malignancies although results need interpreted caution due lack granular data suggest ecmo appears represents viable rescue option selected patients underlying malignancies urgent need additional data define patients ecmo may provide benefit harm