Christopher Kabrhel|Raphäelle Varraso|Samuel Z. Goldhaber|Eric B. Rimm|Carlos A. Camargo
Physical inactivity and idiopathic pulmonary embolism in women: prospective study
Massachusetts General Hospital|Harvard University|Centre de recherche en Epidémiologie et Santé des Populations|Inserm|University of Paris-Sud|Brigham and Women's Hospital|Harvard University|Harvard University|Brigham and Women's Hospital|Massachusetts General Hospital|Brigham and Women's Hospital|Harvard University
determine association physical inactivity sedentary lifestyle incident idiopathic pulmonary embolismprospective cohort studynurses health study69 950 female nurses completed biennial questionnaires 1990 2008 main outcome measures primary outcome idiopathic pulmonary embolism confirmed medical records multivariable cox proportional hazards models controlled age body mass index bmi energy intake smoking pack years race spouses educational attainment parity menopause nonaspirin nonsteroidal antiinflammatory drugs warfarin multivitamin supplements hypertension coronary heart disease rheumatological disease dietary patterns primary exposure physical inactivity measured hours sitting day secondary exposure physical activity measured metabolic equivalents dayover 18 year study period 268 cases incident idiopathic pulmonary embolism association time sitting risk idiopathic pulmonary embolism 41104 720 v 1614 565 cases inactive v least inactive combined data p0001 trend risk pulmonary embolism twofold women spent time sitting compared spent least time sitting multivariable hazard ratio 234 95 confidence interval 130 420 association physical activity pulmonary embolism p053 trendphysical inactivity associated incident pulmonary embolism women interventions decrease time sitting could lower risk pulmonary embolism