Job van der Palen|Mike Thomas|Henry Chrystyn|Raj Kumar Sharma|P.D.L.P.M. van der Valk|Martijn Goosens|Tom Wilkinson|Carol Stonham|Anoop Chauhan|Varsha Imber|Chang Qing Zhu|Henrik Svedsäter|Neil Barnes
A randomised open-label cross-over study of inhaler errors, preference and time to achieve correct inhaler use in patients with COPD or asthma: comparison of ELLIPTA with other inhaler devices
Medisch Spectrum Twente|University of Southampton|Medisch Spectrum Twente|Gelre Hospitals|University of Southampton|Queen Alexandra Hospital|Health Economics and Outcomes Research (United Kingdom)
errors use different inhalers investigated patients naive devices investigation multicentre singlevisit randomised openlabel crossover study patients chronic obstructive pulmonary disease copd asthma assigned ellipta vs diskus accuhaler metereddose inhaler mdi turbuhaler patients copd also assigned ellipta vs handihaler breezhaler patients demonstrated inhaler use reading patient information leaflet pil trained investigator assessed critical errors ie likely result inhalation significantly reduced minimal medication patient made errors investigator demonstrated correct use inhaler patient demonstrated inhaler use fewer copd patients made critical errors ellipta reading pil vs diskus 9171 5 vs 75171 44 mdi 1080 13 vs 4880 60 turbuhaler 8100 8 vs 44100 44 handihaler 17118 14 vs 57118 48 breezhaler 1398 13 vs 4598 46 p0001 patients 5770 made errors using ellipta require investigator instruction instruction required diskus 65 mdi 85 turbuhaler 71 handihaler 62 breezhaler 56 fewer asthma patients made critical errors ellipta reading pil vs diskus 370 4 vs 970 13 p0221 mdi 232 6 vs 832 25 p0074 significantly fewer vs turbuhaler 360 5 vs 2060 33 p0001 asthma copd patients preferred ellipta devices p0002 significantly fewer copd patients using ellipta made critical errors reading pil vs inhalers asthma copd patients preferred ellipta comparator inhalers