Erin Passmore, Tanner Smith
Dual Burden of Stunting and Obesity Among Elementary School Children on Majuro, Republic of Marshall Islands
Hawai'i journal of health & social welfare
rich data large biobanks coupled increasingly accessible association statistics genomewide association studies gwas provide great opportunities dissect complex relationships among human traits diseases introduce badgers powerful method perform polygenic scorebased biobankwide association scans compared traditional approaches badgers uses gwas summary statistics input require multiple traits measured cohort applied badgers two independent datasets lateonset alzheimers disease ad n61212 among 1738 traits uk biobank identified 48 significant associations ad family history high cholesterol numerous traits related intelligence education showed strong independent associations ad furthermore identified 41 significant associations variety ad endophenotypes family history high cholesterol strongly associated ad subgroups pathologies intelligence educationrelated traits predicted preclinical cognitive phenotypes results provide novel insights distinct biological processes underlying various risk factors ad