P Butow, C Napier, R Campbell, N Bartley, M Best, M L Ballinger
Validation of the Knowledge of Genome Sequencing (KOGS) scale in cancer patients
Patient education and counseling
systematic review metaanalysis designed order ascertain effectiveness respiratory syncytial virus rsv vaccination preventing lower respiratory tract diseases lrtd older adults age 60 years studies reporting randomized controlled trials rcts searched three databases pubmed embase scopus preprint repository medrxiv 31 march 2024 total nine studies eventually included two conference proceedings analysis included five rcts five rsv vaccines rsvpref rsvpref3 ad26rsvpref medi7510 mrna1345 metaanalysis documented pooled vaccine efficacy 8138 95 confidence interval 95 ci 7094 8806 prevention lrtd three signssymptoms first rsv season delivery vaccine followup data available rsvpref3 2 rsv seasons rsvpref midterm estimates second rsv season mrna1345 12 months delivery primer pooled 6115 95 ci 4529 7240 first season overall risk developing rsvrelated lrtd therefore substantially increased risk ratio rr 4326 95 ci 2415 7748 however estimates affected substantial heterogeneity suggested 95 ci i2 statistics could explained inconsistencies design parent studies particularly dealing case definition conclusion adult rsv vaccination quite effective preventing lrtd older adults overall efficacy rapidly decreased second season delivery vaccine heterogenous design parent studies analyses required tailoring specific public health interventions