Oliverio Stefania, Ferger Marie-Caroline, Yegles Michel
Postmortem concentrations for total blood carbon monoxide (TBCO) as novel biomarker for carbon monoxide (CO) poisonings
Journal of analytical toxicology
gastric cancer prevalent deadly malignancy response immunotherapy varies among patients study aimed develop prognostic model gastric cancer patients investigate immune escape mechanisms using deep machine learning singlecell sequencing analysis data public databases analysed prediction model constructed using 101 algorithms highaidps group characterized increased aidps expression exhibited worse survival genomic variations immune cell infiltration patients also showed immunotherapy tolerance treatment strategies targeting highaidps group identified three potential drugs additionally distinct cluster groups upregulated aidpsassociated genes observed gastric adenocarcinoma cell lines inhibition ghrl expression suppressed cancer cell activity inhibited m2 polarization macrophages reduced invasiveness overall aidps plays critical role gastric cancer prognosis genomic variations immune cell infiltration immunotherapy response targeting ghrl expression holds promise personalized treatment findings contribute improved clinical management gastric cancer