Yueh-Hsiu Mathilda Chiu|Hsiao?Hsien Leon Hsu|Brent A. Coull|David C. Bellinger|Itai Kloog|Joel Schwartz|Robert O. Wright|Rosalind J. Wright
Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations
Icahn School of Medicine at Mount Sinai|Icahn School of Medicine at Mount Sinai|Harvard University|Boston Children's Hospital|Harvard University|Ben-Gurion University of the Negev|Harvard University|Icahn School of Medicine at Mount Sinai|Child Health and Development Institute|Child Health and Development Institute|Icahn School of Medicine at Mount Sinai
brain growth structural organization occurs stages beginning prenatally toxicants may impact neurodevelopment differently dependent upon exposure timing fetal sex implemented innovative methodology identify sensitive windows associations prenatal particulate matter diameter 25 pm25 childrens neurodevelopment assessed 267 fullterm urban childrens prenatal daily pm25 exposure using validated satellitebased spatiotemporally resolved prediction model outcomes included iq wisciv attention omission errors oes commission errors ces hit reaction time hrt hrt standard error hrtse conners cptii memory general memory gm index components verbal vem visual vim memory attentionconcentration ac indices wraml2 assessed age 65 098 years identify role exposure timing used distributed lag models examine associations weekly prenatal pm25 exposure neurodevelopment sexspecific associations also examined mothers primarily minorities 60 hispanic 25 black 69 12 years education adjusting maternal age education race smoking found associations higher pm25 levels 3138 weeks lower iq 2026 weeks gestation increased oes 3236 weeks slower hrt 2240 weeks increased hrtse among boys significant associations found memory domains girls higher pm25 exposure 1826 weeks reduced vim 1220 weeks reduced gm increased pm25 exposure specific prenatal windows may associated poorer function across memory attention domains variable associations based sex refined determination time window sexspecific associations may enhance insight underlying mechanisms identification vulnerable subgroups