Wenyan Li, Yanhua Li, Wenli Xu, Zhiyu Chen, Yuyang Gao, Zhen Liu, Qi Li, Ming Jiang, Hanmin Liu, Biru Luo, Yu Zhan, Li Dai
Maternal PM2.5 exposure and hypospadias risk in Chinese offspring: Insights from a nationwide surveillance-based study
Journal of hazardous materials
study aimed compare rate hypoglycemic events spontaneously reported adverse events aes insulin detemir insulin degludec using korea adverse event reporting system kaers database analyzed data reported hypoglycemia events retrieved adverse drug reactions adr use different insulin types 2016 2017 korea institute drug safety risk managementkorea adverse event reporting system database kidskd defining hypoglycemic events ae interest performed disproportionality analysis calculating reporting odds ratio ror identify disproportionality aes following treatment insulin degludec ideg insulin detemir idet spontaneously reported hypoglycemic events distinguished insulin glargine 100 uml gla100 insulin glargine 300 uml gla300 due atc code kidskd direct comparisons gla100 gla300 comparisons analog insulin glargine vs idet ideg respectively could achieved 3220 aes caused use longacting basal insulin 739 296 caused ideg idet respectively among 172 233 739 83 280 296 aes reported hypoglycemic events caused ideg idet respectively rate reported hypoglycemic events caused ideg lower idet ror 95 ci 078 071 086 ideg consistently caused lower hypoglycemia events idet sensitivity analysis ror 95 ci 041 037 046 compared proportionality hypoglycemic events among total number reported aes two basal insulins disproportionality analysis using spontaneous adr reporting system ideg showed relatively lower rate reported hypoglycemic events idet