Elaine Lehane, Geraldine McCarthy, Valerie Collender, Ann Deasy
Medication-taking for coronary artery disease - patients' perspectives
European journal of cardiovascular nursing
kras nras braf mutations microsatellite instability msi associated colorectal cancer crc development evaluated 828 medical records crc patients school hospital january2016 december2020 variables age gender ethnicity literacy level smoking alcoholism primary anatomical site tumor staging presence brafv600e kras nras mutations msi survival metastasis identified statistical analyses performed p 005 considered significant predominance males 5193 whites 9070 low education 7234 smokers 7379 nonalcoholics 7910 rectum affected site 4214 advanced tumor stage prevalent 6207 metastasis occurred 6461 enrolled patients 204 investigated braf mutation detected 294 216 kras gene detected 2608 210 nras gene detected 2536 370 msi detected 4468 significant association crc nras mutation alcohol habit p 0043 observed presence msi associated primary site proximal colon p 0000 distal colon p 0001 rectum p 0010 patients crc male 64 years old white low education smokers nonalcoholics affected primary site rectum advanced stage metastasis crc associated nras mutation alcohol habit increased risk primary site proximal colon msi decreased risk distal colon rectum presence msi