University of Manchester|Wellcome Centre for Human Genetics|Wellcome Centre for Human Genetics|University of Manchester|Wellcome Centre for Human Genetics|University of Manchester|Wellcome Centre for Human Genetics|University of Manchester|Wellcome Centre for Human Genetics|University of Manchester|University of Manchester|Wellcome Centre for Human Genetics|Wellcome Centre for Human Genetics|University of Manchester|Wellcome Centre for Human Genetics|University of Manchester|Wellcome Centre for Human Genetics|University of Manchester
deficits phonological shortterm memory aspects verb grammar morphology proposed phenotypic markers specific language impairment sli suggestion traits likely different genetic influences investigation 300 firstdegree relatives 93 probands sli examined familial aggregation genetic linkage two measures thought index two traits nonword repetition tense marking particular involvement chromosomes 16q 19q examined previous studies found two regions related sli results showed strong association relatives probands scores nonword repetition contrast association found tense marking examined continuous measure however significant familial aggregation found tense marking treated binary measure cutoff point 15 sd suggestive possibility qualitative distinctions trait may familial quantitative variability may consequence nonfamilial factors linkage analyses supported previous findings sli consortium linkage chromosome 16q phonological shortterm memory chromosome 19q expressive language addition report new findings relate past tense phenotype continuous measure linkage found chromosomes evidence stronger chromosome 19 binary measure linkage observed chromosome 19 chromosome 16