W. Thomas Boyce
Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress
University of California, San Francisco
swiftly growing volume literature comprising human animal studies employing observational experimental designs documented striking individual differences neurobiological sensitivities environmental circumstances within subgroups study samples differential susceptibility social physical environments operates bidirectionally adverse beneficial contexts results minority subpopulation remarkably poor unusually positive trajectories health development contingent upon character environmental conditions differences contextual susceptibility appear emerge early development interactive adaptive product genetic environmental attributes paper surveys currently known mechanisms mediators differential susceptibility levels temperament behavior physiological systems brain circuitry neuronal function genetic epigenetic variation concludes assertion differential susceptibility inherently grounded within processes biological moderation complexities present partially understood