Anamika Verma, Radhakrishnan Govindan, Rajalakshmi Ramu, Bino Thomas
Effectiveness of structured teaching program on parents' knowledge about child physical abuse
Journal of education and health promotion
objective study aimed explore risk factors metabolic characteristics potential biomarkers mild cognitive impairment type 2 diabetes mellitus t2dmmci provide potential evidence diagnosis prevention treatment mild cognitive impairment mci patients type 2 diabetes mellitus t2dm methods total 103 patients t2dm recruited endocrinology department second affiliated hospital dalian medical university inclusion study montreal cognitive assessment moca utilized evaluate cognitive functioning patients among 50 patients categorized t2dmmci group moca score 26 points 53 subjects classified t2dm without cognitive impairment t2dmnci group moca score 26 points serum samples collected subjects metabolomics profiling data generated ultrahigh performance liquid chromatographymass spectrometry uhplcms groups analyzed investigate differences expression small molecule metabolites metabolic pathways potential specific biomarkers results comparison t2dmmci group t2dmnci group revealed significant differences years education history insulin application insulin resistance index insulinlike growth factorbinding protein3 igfbp3 creatinine levels binary logistic regression analysis variables indicated low educational level low serum igfbp3 independent risk factor t2dmmci metabolomics analysis revealed differential expression 10 metabolites t2dmmci group t2dmnci group p 005 fdr005 vip15 kyoto encyclopedia genes genomes kegg enrichment pathway analysis revealed fatty acid degradation significant pathway receiver operating characteristic roc analysis shows lysophosphatidylcholine lpc 180 exhibited greater diagnostic efficiency conclusion study revealed shorter duration education lower serum igfbp3 levels independent risk factors t2dmmci serum metabolites found altered t2dmmci t2dmnci groups t2dm patients without mci distinguished lpc 180 abnormal lipid metabolism plays significant role development mci t2dm patients