Kate Baker|David Skuse
Adolescents and young adults with 22qll deletion syndrome: psychopathology in an at-risk group
University College London|University College London
background 22q11 deletion syndrome associated high rates psychiatric morbidity especially schizophrenia common neurodevelopmental trajectories characterise 22q11 deletion syndrome idiopathic schizophrenia similar premorbid features would predicted aims define psychopathology adolescents young adults 22q11 deletion syndrome method individuals 22q11 deletion syndrome n 25 age iqmatched comparison participants n 25 along withtheir parentscarers completed standardised semistructured assessments results psychiatric disorders prevalent among syndrome included attention deficit depression anxiety nearly half reported transient psychotic experiences inappropriate emotionality disrupted social behaviour also common poor functional adjustment associated schizotypal symptoms marked older individuals conclusions 22q11 deletion syndrome associated significant psychopathology prior adulthood double proportion expected develop schizophrenia reported psychotic phenomena findings imply continuum developmental disruption 22q11 deletion syndrome associated declining mental health early adulthood