Jessica M. Black|Hiroko Tanaka|Leanne Stanley|Masato Nagamine|Nahal Zakerani|Alexandra Thurston|Shelli R. Kesler|Charles Hulme|Heikki Lyytinen|Gary H. Glover|Christine Serrone|Mira M. Raman|Allan L. Reiss|Fumiko Hoeft
Maternal history of reading difficulty is associated with reduced language-related gray matter in beginning readers
Stanford University|Palo Alto University|Stanford University|Palo Alto University|Stanford University|National Defense Medical College|Palo Alto University|Stanford University|Stanford University|Palo Alto University|Stanford University|University College London|University of Jyväskylä|Stanford University|Stanford University|Stanford University|Stanford University|Stanford University
family history poor preliteracy skills referred familial behavioral risk respectively critical predictors developmental dyslexia study systematically investigated independent contribution familial behavioral risks brain structures explored past studies also examined differential effects maternal versus paternal history brain morphometry familial risk dimensionally versus categorically also novel aspects study assessed 51 children 5 6 years age varying degrees familial behavioral risks developmental dyslexia examined associations brain morphometry found greater maternal history reading disability associated smaller bilateral prefrontal parietotemporal gray white matter volumes regressing behavioral risk socioeconomic status maternal education confounds change results relationship observed paternal reading history behavioral risk results cortical surface area thickness showed significant negative relationship cortical surface area thickness greater severity maternal history particular within left inferior parietal lobule suggesting prenatal influence maternal history childrens brain morphometry results suggested greater maternal possibly prenatal influence languagerelated brain structures results help guide future neuroimaging research focusing environmental genetic influences provide new information may help predict child develop dyslexia future