S Kavikondala|Chao Jiang|Wei Sen Zhang|Kar Keung Cheng|Tai Hing Lam|Gabriel M. Leung|C. Mary Schooling
Intergenerational ‘mismatch’ and adiposity in a developing population: The Guangzhou biobank cohort study
University of Hong Kong|Twelfth Guangzhou City People's Hospital|Twelfth Guangzhou City People's Hospital|University of Birmingham|University of Hong Kong|University of Hong Kong|University of Hong Kong
intergenerational mismatch maternal adult environments common developing economies hypothesized contributing obesity rapidly developing population examined whether maternal conditions proxied maternal literacy associated adult adiposity proxied body mass index bmi waisthip ratio whr whether associations modified later life conditions proxied socioeconomic position sep three life stages also examined maternal conditions sexspecific associations adult adiposity crosssectional study 19957 adults 50 years guangzhou biobank cohort study phases 2 3 20052008 used multivariable linear regression assess association maternal literacy bmi whr whether associations varied sex age sep adjusted association maternal literacy whr varied sex women men maternal illiteracy associated higher whr bmi adjusted age associations remained although attenuated adjusting lifestyle life course sep paternal literacy little evidence associations varied sep stage although continuity poor conditions early life may exacerbated association maternal illiteracy higher whr women poor maternal conditions developing populations may increase vulnerability adiposity women whether sexspecific intergenerational effects driven epigenetics maternal sex hormones mechanisms remains determined however mismatched maternal later life conditions appear associated adiposity findings although preliminary imply transient epidemic obesity may occur first generation women experience economic development