YaXuan Wang, JiaXing He, QingYun Zhao, Ji Bo, Yu Zhou, HaoDong Sun, BeiChen Ding, MingHua Ren
Evaluating the predictive value of angiogenesis-related genes for prognosis and immunotherapy response in prostate adenocarcinoma using machine learning and experimental approaches
Frontiers in immunology
article describes test guatemala city mantente real linguistically adapted version keepin real universal substance use prevention curriculum early adolescents teaches culturally grounded drug resistance risk assessment decision making skills academic researchers collaborated local nonprofit recruit randomize 12 elementary schools guatemala city intervention comparison conditions regular classroom teachers trained deliver tenlesson mantente real mr manualized curriculum sixthgrade students parents provided passive consent students gave active assent data collection occurred february 2013 september 2014 two academic year cohorts students participated n 676 53 male age 122 students completed pretest questionnaire curriculum lessons began intervention schools posttest 87 matched 4 months later 1 month final lesson assessed mr intervention paired tests effect sizes cohens general linear models adjusted baseline attrition nonlinear distributions schoollevel clustering results indicated mr effective schoolbased prevention approach guatemala mr participants reported pretesttoposttest changes desirable directions substance use behaviors attitudinal antecedents substance use acquisition drug resistance skills comparison group generally changed undesirable directions linear models mr participants relative comparison group reported less cigarette marijuana use less positive drug use expectancies greater use drug resistance skills intervention effect sizes 2 3