Lynn M. Almli|Kristina B. Mercer|Kimberly Kerley|Hao Feng|Bekh Bradley|Karen N. Conneely|Kerry J. Ressler
<i>ADCYAP1R1</i> genotype associates with post?traumatic stress symptoms in highly traumatized African?American females
Emory University|Emory University|Howard Hughes Medical Institute|Howard Hughes Medical Institute|Emory University|Emory University|Emory University|Emory University|Howard Hughes Medical Institute
pituitary adenylate cyclaseactivating polypeptide pacap receptor pac1 play critical role biological processes mediate stress response implicated psychological outcome following trauma previous work ressler et al 2011 nature 470492497 demonstrated variant rs2267735 gene encoding pac1 adcyap1r1 associated posttraumatic stress disorder ptsd primarily africanamerican cohort highly traumatized females sought extend replicate previous finding similarly traumaexposed replicate sample 1160 africanamerican adult male female patients selfreported psychiatric measures collected dna obtained genetic analysis using linear regression models test association ptsd symptom severity additive allelic model found genotype trauma interaction females p 0001 males p 01 however main effect genotype previous study observed interaction suggests genetic association increases degree trauma exposure females interaction remained significant females males controlling age p 0001 income p 001 past substance abuse p 0001 depression severity p 002 child abuse p 00005 five combined p 001 significant effects genotype interactions found modeling depression severity controlling comorbid ptsd symptom severity p 01 demonstrating relative specificity variant ptsd symptoms metaanalysis previously reported africanamerican samples revealed strong association ptsd symptom severity interaction trauma genotype females n 1424 p 00001