Lindsay C. Kobayashi|M. Maria Glymour|Kathleen Kahn|Collin F. Payne|Ryan G. Wagner|Livia Montana|Farrah J. Mateen|Stephen Tollman|Lisa F. Berkman
Childhood deprivation and later-life cognitive function in a population-based study of older rural South Africans
University of California, San Francisco|University of the Witwatersrand|Agincourt Health and Socio-Demographic Surveillance System|Indepth Network|Umeå University|University of the Witwatersrand|Agincourt Health and Socio-Demographic Surveillance System|Indepth Network|Harvard University|University of the Witwatersrand|Agincourt Health and Socio-Demographic Surveillance System|Indepth Network|Umeå University|University of the Witwatersrand|Agincourt Health and Socio-Demographic Surveillance System
little research evaluated life course drivers cognitive aging south africa investigated relationships selfrated childhood health fathers occupation childhood laterlife cognitive function score whether educational attainment mediated relationships among older south africans living former region apartheidera racial segregation data baseline assessments health aging africa longitudinal study indepth community haalsi populationbased study 5059 men women aged 40 years 2015 rural agincourt subdistrict south africa childhood health fathers occupation childhood years education selfreported study interviews cognitive measures assessed time orientation numeracy word recall included zstandardized latent cognitive function score variable linear regression models adjusted age sex country birth used estimate total direct effects childhood risk factor indirect effects mediated years education poor childhood health predicted lower cognitive scores total effect 028 95 ci 035 021 versus good effect mediated educational attainment father professional job childhood rare 3 sample predicted better cognitive scores total effect 025 95 ci 010 040 versus unskilled manual labor 29 sample half effect mediated educational attainment education linearly associated laterlife cognitive function score 009 95 ci 009 010 per year achieved postapartheid rural south african context older adults poor selfreported childhood health whose father worked unskilled manual labor relatively poor cognitive outcomes educational attainment strongly predicted cognitive outcomes appeared part mechanism social stratification laterlife cognitive health context