Yongming Zhang, Ting Huang, Mengling Tang, Lin Meng, Xiaolu Wu, Kun Chen
An effectiveness evaluation of a community-based course for medical students: a randomized controlled trial in the teaching of epidemiology
BMC medical education
low middleincome countries lmics including india cancer patients poor prognosis late diagnosis cases already grown advanced stages low cancer awareness skewed cancer care facilities india incidence colorectal cancer crc ranked 4th common 64 males 5th common 34 females improvement cure rate rectal cancer increased life expectancy assessment quality life qol patients become fundamental requirement little known patients perceive adverse effects curatively intended radiotherapy although studies investigated various adverse effects occur radiotherapy chemotherapy carcinoma rectum patients yet critically appraised synopsized form comprehensive review prevalence effects qol study designed explore qol issues locally advanced carcinoma rectum patients various phases neoadjuvant concurrent chemoradiotherapy naccrt study performed period 2 years single super speciality cancer hospital north india patients selected per inclusion criteria followed standard questionnaire incorporating various aspects depicting qol interview technique used collecting qol data four points baseline midway treatment end treatment 4 weeks completion naccrt using eortc qlq c30 qlq cr29 special care taken avoid observer bias cases language issues interpreters services utilised compared baseline pretreatment scores patients reported statistically significant large clinically meaningful change global health status social functioning fatigue facitf appetite loss anxiety sore skin male female sexual function posttreatment time point statistically significant changes moderate clinically meaningful changes reported functional scalesphysical role emotional functioning qlq c30 questionnaire body image weight cr29 questionnaire similar moderate clinical changes found symptom scalesfatigue nausea vomiting insomnia constipation diarrhoea qlq c30 stool frequency embarrassment bowel function impotence dyspareunia parameters returned almost pretreatment values 4 weeks completion nacrt since qol relatively subjective variable differences human race culture education social environment impacts results international cooperation needed study qol patients multiple cultural backgrounds existing qol questionnaire tools designed western countries mind face multiple social issues suggest many similar multicentre studies shall required essentially tap accurate qolrelated issues keeping mind diverse social economic racial educational backgrounds deal everincreasing cancer menace better life expectancy qol issues shall major determinant treatment success besides primary treatment factors form integral part treatment modality adequate counselling must performed prior initiation care