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manuscript interest clinical translational science awards ctsa retool increasing emphasis translational science translational research effort extension edw4r work ctsas done deploy infrastructure tools researchers access clinical data iowa health data resource ihdr strategic investment made university iowa improve access realworld health data goals ihdr improve speed translational health research boost interdisciplinary collaboration improve literacy health data first objective toward larger goal address gaps data access data literacy lack computational environments processing personal health information phi lack processes expertise creating transformative datasets threepronged approach taken address objective approach involves integration intercollegiate team noninformatics faculty staff data enclave secure patient data analyses novel comprehensive datasets date five health science colleges dentistry medicine nursing pharmacy public health least one staff one faculty member complete twomonth experiential learning curriculum first two years project nine cohorts totaling 36 data liaisons trained including 18 faculty 18 staff ihdr data enclave eliminated need duplicate computational infrastructure inside hospital firewall reduced infrastructure hardware human resource costs leveraging existing expertise embedded university research computing team creation process develop implement transformative datasets resulted creation seven domain specific datasets date combination people process technology facilitates collaboration interdisciplinary research secure environment using curated data sets organizations implemented individual components address edw4r operational demands ihdr combines multiple resources novel comprehensive ecosystem ihdr enables scientists use analysis tools electronic patient data accelerate time science