Min-Song Kim, Sang-Hee Kim
Health information-seeking behavior in patients with coronary artery disease: Activating methods
PloS one
alzheimers disease ad leading cause dementia resulting impairments memory cognition decisionmaking social skills thus accurate preclinical diagnosis alzheimers disease paramount identification biomarkers alzheimers disease magnetic resonance spectroscopy mrs represents novel adjunctive diagnostic approach study conducted metaanalysis diagnostic results technology explore feasibility accuracy pubmed cochrane library embase web science databases searched without restrictions search period extending july 31 2022 search strategy employed combination subject headings keywords retrieved documents underwent screening two researchers selected metaanalysis included literature analyzed using review manager 54 software corresponding bias maps forest plots summary receiver operating characteristic sroc curves generated analyzed total 344 articles retrieved initially 11 articles meeting criteria inclusion analysis analysis encompassed data approximately 1766 patients forest plot sensitivity 95 ci specificity 95 ci approached 1 examining true positive rate false positive rate true negative rate false negative rate studies summary receiver operating characteristic sroc curve clustered upper left quadrant suggesting high accuracy biomarkers detected mrs diagnosing alzheimers disease detection biomarkers mrs demonstrates feasibility high accuracy diagnosing ad technology holds promise widespread adoption clinical diagnosis ad future