Ellen V. Backhouse|Caroline McHutchison|Vera Cvoro|Susan D. Shenkin|Joanna M. Wardlaw
Early life risk factors for cerebrovascular disease
University of Edinburgh|University of Edinburgh|University of Edinburgh|University of Edinburgh|University of Edinburgh
h3objectiveh3 cerebrovascular disease cvd causes subclinical brain vascular lesions detected using neuroimaging childhood factors may increase later cvd risk h3methodsh3 searched medline psycinfo embase metaanalyzed available evidence childhood premorbid iq socioeconomic status ses education subclinical cvd later life overall odds ratios mean difference correlation 95 confidence intervals cis calculated using random effects methods h3resultsh3 identified 30 relevant studies n 22890 lower childhood iq lower childhood ses associated white matter hyperintensities wmh iq n 1512 iri 007 95 ci 012 002 ipi 0007 ses n 243 deep wmh iri 018 periventricular wmh iri 0146 fewer years education associated several cvd markers n 15439 117 95 ci 105 131 ipi 0003 studies assessed early life factors combined h3conclusionsh3 childhood iq ses education associated increased risk cvd neuroimaging later life studies required provide evidence thereby inform policy