Andinet Alemu|Miguel San Sebastián
Determinants of survival in adult HIV patients on antiretroviral therapy in Oromiyaa, Ethiopia
Umeå University|Umeå University
background antiretroviral treatment art scaleup service recent development ethiopia impact mortality well investigated aim study assess early survival outcome scaleup service utilizing routine hospital datamethods adult hivaids patients started antiretroviral treatment shashemene assela hospitals january 1 2006 may 31 2006 included followed 2 years data extracted standard patient medical registrations kaplanmeier curves used estimate survival probability cox proportional hazard model applied determine predictors mortality two alterative assumptions real case worst case made determining predictors mortalityresults median age patients 33 years 57 female eightyfive percent cd4 200 cellsl median cd4 count 103 cellsl median survival time 1044 weeks total 28 103 deaths observed 2year period 48 patients 18 lost follow majority deaths occurred first 4 months treatment multivariate analysis 2year survival significantly associated clinical stage disease baseline hemoglobin cotrimoxazole prophylaxis therapy cpt art initiation assumptions median cd4 count body weight showed marked improvement first 6 months treatment followed stagnation thereafterconclusion study shown overall low mortality high loss followup rate cohort advanced clinical stage anemia low body weight lack cpt initiation independent predictors mortality gender cpt initiation encouraged routine hiv care services patient retention mechanisms strengthened stagnation immunological weight recovery first 6 months investigated utilization routine data encouraged order facilitate appropriate decision making