Ellen Janssen|Rachael L. DiSantostefano|Marie Falahee|Gwenda Simons|M Englbrecht|C Radawski|Karim Raza|Brett Hauber|Jorien Veldwijk
P19 Assessing Heterogeneity in MAR: Methods and Models Beyond DCE
Janssen (United States)|Janssen (United States)|University of Birmingham|University of Birmingham|University of Birmingham|Pfizer (United States)|Erasmus University Rotterdam
discrete choice experiments dces robust statedpreference methods frequently used estimate maximum acceptable risk mar secondary outcome however dces provide samplelevel estimates explaining preference heterogeneity mars based participant characteristics difficult study objective compare capability dce probabilistic threshold technique ptt identify preference heterogeneity among mars preventive rheumatoid arthritis ra treatment participants 3 countries united kingdom uk germany romania n 2959 completed dce ptt random order participants made choices treatments reduced chance developing ra increased chance three risks mild serious side effects serious infection ptt interval regressions estimated mars accounted age education numeracy literacy ra family history dce random parameters logit rpl models used calculate mars subgroups heterogeneity identified ptt ptt identified preference heterogeneity numeracy literacy family history regarding characteristics ptt identified statistically significantly different mars p005 least one risk least two countries dce identified preference heterogeneity chance serious infection uk participants low vs high numeracy p005 using dce statistically different mars identified combinations participant characteristics risks countries ptt identified preference heterogeneity mars participant characteristics directly incorporating participant characteristics regression model attempting estimate mars ptt may partially overcome challenges stratified dce models particularly analyses latent class analysis feasible desirable research needed confirm findings case studies explore method accurately identify true underlying preference heterogeneity needed