Lara Vinhal Faria, Isabel Cristina Martins Emmerick, Mario Jorge Sobreira da Silva
Effect of municipal and state regulation on access and outcomes for cervical cancer patients in Rio de Janeiro, Brazil: An interrupted time series analysis
Journal of cancer policy
striatum plays central role directing many complex behaviors ranging motor control action choice reward learning study used 55 cfw mice rapid decay linkage disequilibrium systematically mine striatumrelated behavioral functional genes analyzing striatal transcriptomes 79 measured behavioral phenotypic data constructing gene coexpression network clustered genes 13 modules positively correlated motor traits based functional annotations well fishers exact hypergeometric distribution tests brown magenta modules identified core modules significantly enriched striatalrelated functional genes subsequent mendelian randomization analysis verified causal relationship core modules dyskinesia intramodular gene connectivity analysis adcy5 kcnma1 identified brown magenta module hub genes respectively knockouts adcy5 kcnma1 lead motor dysfunction mice kcnma1 acts risk gene schizophrenia smoking addiction humans also evaluated cellular composition module identified oligodendrocytes striatum positive role motor regulationsignificance statement striatum plays central role guiding many complex behaviours motor control action selection reward learning clinically striatal dysfunction contributes variety neurodegenerative diseases including wellknown alzheimers disease huntingtons disease study systematically mined striatumassociated behavioural function genes using 55 cfw mice validated findings multiple ways found adcy5 kcnma1 knockouts mice lead motor dysfunction mice kcnma1 associated schizophrenia finding holds true humans finally also assessed role different cells regulation striatal behaviour found oligodendrocytes striatum play active role movement regulation