Adrienne B Nicotra, Sonya R Geange, Nur H A Bahar, Hannah Carle, Alexandra Catling, Andres Garcia, Rosalie J Harris, Megan L Head, Marvin Jin, Michael R Whitehead, Hannah Zurcher, Elizabeth A Beckmann
An innovative approach to using an intensive field course to build scientific and professional skills
Ecology and evolution
oral anticoagulants oacs reduce risk ischemic stroke may increase risk major bleeding patients nonvalvular atrial fibrillation nvaf various risk scores hasbled atria orbit doac proposed assess risk major bleeding patients nvaf receiving oacs however limited data available regarding bleeding risk stratification japanese patients nvaf 16098 nvaf patients jrisk af study combined data five major af registries japan jrhythm registry fushimi af registry shinken database keio interhospital cardiovascular studies hokurikuplus af registry analyzed 11539 patients receiving oacs median age 71 years old women 296 median cha2ds2vasc score 3 2year followup period major bleeding occurred 274 patients 13 per patientyear multivariate cox proportional hazards analysis advanced age hypertension systolic blood pressure 150 mmhg bleeding history anemia thrombocytopenia concomitant antiplatelet agents significantly associated higher incidence major bleeding developed novel risk stratification system hedepa2b3 score better predictive performance major bleeding cstatistics 067 95 confidence interval 063070 hasbled 064 060067 p difference 002 atria 063 060066 p difference 001 scores furthermore nonsignificantly higher orbit 065 062068 p difference 007 doac 065 062068 p difference 017 scores novel risk stratification system hedepa2b3 score may useful identifying japanese patients receiving oacs risk major bleeding