Hyun-Ju Jun, Ki-Jong Kim, In-Ae Chun, Ok-Kon Moon
The relationship between stroke patients' socio-economic conditions and their quality of life: the 2010 Korean community health survey
Journal of physical therapy science
report use deep learning model design de novo proteins based interplay elementary building blocks via hierarchical patterns deep neural network model based translating protein sequences structural information musical score features different pitches amino acids variations note length note volume reflecting secondary structure information information chain length distinct protein molecules train deep learning model whose architecture composed several long shortterm memory units data consisting musical representations proteins classified certain features focused alphahelix rich proteins using deep learning model generate de novo musical scores translate pitch information chain lengths sequences amino acids use basic local alignment search tool compare predicted amino acid sequences known proteins estimate folded protein structures using optimized protein fold recognition method orion modeller find method proposed used design de novo proteins exist yet designed proteins fold specified secondary structures validate newly predicted protein molecular dynamics equilibration explicit water subsequent characterization using normal mode analysis method provides tool design novel protein materials could find useful applications materials biology medicine engineering