Pooja V Hegde, Bridget L Morse
Mechanistic account of distinct change in organic anion transporting polypeptide 1B (OATP1B) substrate pharmacokinetics during OATP1B-mediated drug-drug interactions using physiologically-based pharmacokinetic modeling
Drug metabolism and disposition: the biological fate of chemicals
evidencebased treatments available gulf war illness gwi behavioral treatments target factors known maintain disability gwi problemsolving impairment may beneficial problemsolving treatment pst targets problemsolving impairment evidencebased treatment conditions examine efficacy pst reduce disability problemsolving impairment physical symptoms gwi multicenter randomized clinical trial conducted us department veterans affairs compared pst health education volunteer sample 511 gulf war veterans gwi disability january 1 2015 september 1 2019 outcomes assessed 12 weeks 6 months statistical analysis conducted january 1 2019 december 31 2020 problemsolving treatment taught skills improve problemsolving health education provided didactic health information delivered telephone weekly 12 weeks primary outcome reduction baseline 12 weeks selfreport disability world health organization disability assessment schedule secondary outcomes reductions selfreport problemsolving impairment objective problemsolving exploratory outcomes reductions pain pain disability fatigue total 268 veterans mean sd age 529 73 years 884 male 668 white randomized pst n 135 health education n 133 participants completed 12 sessions pst 114 135 844 health education 120 133 902 difference found groups reductions disability end treatment results suggested pst reduced problemsolving impairment moderate effect 042 p 01 disability 6 months moderate effect 039 p 06 compared health education randomized clinical trial efficacy pst gwi difference found groups reduction disability 12 weeks problemsolving treatment high adherence reduced problemsolving impairment potentially reduced disability 6 months compared health education findings confirmed future studies clinicaltrialsgov identifier nct02161133