Sarah R. Hatt|David A. Leske|Elizabeth Bradley|Stephen R. Cole|Jonathan M. Holmes
Development of a Quality-of-Life Questionnaire for Adults with Strabismus
Mayo Clinic|Mayo Clinic|Mayo Clinic|Johns Hopkins University|Mayo Clinic
purpose report development patientderived healthrelated qualityoflife hrqol questionnaire adults strabismus design crosssectional study participants twentynine patients strabismus first phase 32 patients strabismus 18 patients eye diseases 13 visually normal adults second phase methods individual patient interviews generated 181 questionnaire items item reduction asked 29 patients strabismus complete 181item questionnaire analyzed responses performed factor analysis two prominent factors identified 10 items highest correlation factor selected final 20item questionnaire 10 psychosocial items 10 function items administered additional 32 patients strabismus 22 diplopia 10 without diplopia 13 visually normal adults 18 patients eye diseases 5point likerttype scale used responses never 100 rarely 75 sometimes 50 often 25 always 0 median overall questionnaire scores psychosocial function subscale scores ranging 0 worst hrqol 100 best hrqol compared across groups main outcome measures hrqol questionnaire response scores results median overall scores statistically significantly lower worse quality life patients strabismus 56 compared visually normal adults 95 p0001 patients eye diseases 86 p0001 median scores psychosocial subscale significantly lower strabismus patients 69 compared visually normal adults 99 p0001 patients eye diseases 94 p0001 function subscale median scores significantly lower strabismus patients 43 compared visually normal adults 91 p0001 patients eye diseases 78 p0001 conclusions developed 20item patientderived hrqol questionnaire specific adults strabismus subscales assess psychosocial function concerns 20item conditionspecific questionnaire useful assessing hrqol individual strabismus patients also outcome measure clinical trials financial disclosures authors proprietary commercial interest materials discussed article report development patientderived healthrelated qualityoflife hrqol questionnaire adults strabismus crosssectional study twentynine patients strabismus first phase 32 patients strabismus 18 patients eye diseases 13 visually normal adults second phase individual patient interviews generated 181 questionnaire items item reduction asked 29 patients strabismus complete 181item questionnaire analyzed responses performed factor analysis two prominent factors identified 10 items highest correlation factor selected final 20item questionnaire 10 psychosocial items 10 function items administered additional 32 patients strabismus 22 diplopia 10 without diplopia 13 visually normal adults 18 patients eye diseases 5point likerttype scale used responses never 100 rarely 75 sometimes 50 often 25 always 0 median overall questionnaire scores psychosocial function subscale scores ranging 0 worst hrqol 100 best hrqol compared across groups hrqol questionnaire response scores median overall scores statistically significantly lower worse quality life patients strabismus 56 compared visually normal adults 95 p0001 patients eye diseases 86 p0001 median scores psychosocial subscale significantly lower strabismus patients 69 compared visually normal adults 99 p0001 patients eye diseases 94 p0001 function subscale median scores significantly lower strabismus patients 43 compared visually normal adults 91 p0001 patients eye diseases 78 p0001 developed 20item patientderived hrqol questionnaire specific adults strabismus subscales assess psychosocial function concerns 20item conditionspecific questionnaire useful assessing hrqol individual strabismus patients also outcome measure clinical trials