Kristin M. Wall|William Kilembe|Bellington Vwalika|Cecile Dinh|Paul Livingston|Yeuk-Mui Lee|Shabir Lakhi|Debi Boeras|Htee Khu Naw|Ilene Brill|Elwyn Chomba|Tyronza Sharkey|Rachel Parker|Erin Shutes|Amanda Tichacek|W. Evan Secor|Susan Allen
Schistosomiasis is associated with incident HIV transmission and death in Zambia
Emory University|Rwanda Zambia HIV Research Group|Rwanda Zambia HIV Research Group|Emory University|Rwanda Zambia HIV Research Group|Emory University|University of Zambia|Rwanda Zambia HIV Research Group|Emory University|Rwanda Zambia HIV Research Group|Emory University|Division of Parasitic Diseases and Malaria|Centers for Disease Control and Prevention|Rwanda Zambia HIV Research Group|Emory University|University of Zambia|Rwanda Zambia HIV Research Group|Emory University|Rwanda Zambia HIV Research Group|Emory University|University of Alabama at Birmingham|Rwanda Zambia HIV Research Group|Emory University|Ministry of Health|Rwanda Zambia HIV Research Group|Emory University|University of Zambia|Rwanda Zambia HIV Research Group|Emory University|Rwanda Zambia HIV Research Group|Emory University|Bill & Melinda Gates Foundation|Rwanda Zambia HIV Research Group|Emory University|Division of Parasitic Diseases and Malaria|Centers for Disease Control and Prevention|Rwanda Zambia HIV Research Group|Emory University
background examined relationships schistosome infection hiv transmission acquisition allcause death methods retrospectively tested baseline sera heterosexual hivdiscordant couple cohort lusaka zambia followup 19942012 nested casecontrol design schistosomespecific antibody levels measured elisa associations baseline antibody response schistosome antigens incident hiv transmission acquisition allcause death stratified gender hiv status assessed subset hiv women hiv men performed immunoblots evaluate associations schistosoma haematobium schistosoma mansoni infection history hiv incidence results 2145 individuals 59 positive baseline schistosomespecific antibody responses hiv women men baseline schistosomespecific antibodies associated hiv transmission partners adjusted hazard ratio ahr 18 p0005 ahr 14 p005 respectively death hiv women ahr 22 p0001 250 hiv women presence haematobiumspecific antibodies associated increased risk hiv acquisition ahr 14 p005 conclusion schistosome infections associated increased transmission hiv sexes acquisition hiv women increased progression death hiv women establishing effective prevention treatment strategies schistosomiasis including urban adults may reduce hiv incidence death hiv persons living endemic areas