Xuemin Dong, Shanshan Dong, Shengkai Pan, Xiangjiang Zhan
RNA-combine: a toolkit for comprehensive analyses on transcriptome data from different sequencing platforms
BMC bioinformatics
thoracic aortic aneurysm taa poses significant health risks due aortic dilation recent evidence suggests pivotal role immuneinflammatory response mechanism aortic aneurysm formation study aim investigate causal relationship circulating immune cells taa study employs twosample mendelian randomization mr approach utilizing genomewide association study gwas summary statistics 731 immune cell types two taa data largescale studies causal effects peripheral immune cells taa taa peripheral immune cells explored ensure accurate results intersected findings two taa data largescale studies excluding results direction odds ratio inconsistent study identifies specific immune cells associated taa notably cd45 nkt cell 095 95ci 090099 finngen study 091 95ci 084099 chip mgi study cd45 hladr cd8 cells 095 95ci 090099 finngen study 090 95ci 082099 chip mgi study demonstrate protective role taa addition cd28 cd45ra cd8 cells relative cell counts absolute cell counts hvem cm cd8 cells adversely affected taa findings indicate potential protective influence exerted specific subsets peripheral nkt cells cd8 cells mitigating development taa simultaneously highlighting reciprocal effects taa peripheral treg cells subsets cell subsets complex interaction immune cells taa could provide valuable clues earlier detection efficacious treatment strategies taa