Maki Koyama|Adriana Di Martino|Clare Kelly|Devika R. Jutagir|J. M. Sunshine|Sanford Schwartz|F. Xavier Castellanos|Michael P. Milham
Cortical Signatures of Dyslexia and Remediation: An Intrinsic Functional Connectivity Approach
Rutgers, The State University of New Jersey|NYU Langone Health|NYU Langone Health|NYU Langone Health|NYU Langone Health|NYU Langone Health|Child Mind Institute|Nathan Kline Institute for Psychiatric Research|NYU Langone Health|Child Mind Institute|Nathan Kline Institute for Psychiatric Research
observational crosssectional study investigates cortical signatures developmental dyslexia particularly perspective behavioral remediation employed restingstate fmri compared intrinsic functional connectivity ifc patterns known reading regions seeds among three dyslexia groups characterized remediation current reading spelling deficits b partial remediation reading deficit remediated c full remediation reading spelling deficits remediated group age iqmatched typically developing children tdc total n 44 age range 715 years observed significant group differences ifc two seeds located left posterior reading network left intraparietal sulcus lips left fusiform gyrus lffg specifically ifc lips left middle frontal gyrus significantly weaker dyslexia groups irrespective remediation statusliteracy competence suggesting persistent dysfunction frontoparietal attention network characterizes dyslexia additionally relative tdc remediation group remediation groups exhibited stronger ifc lffg right middle occipital gyrus rmog full remediation group also exhibited stronger negative ifc lffg seed right medial prefrontal cortex rmpfc core region default network results suggest behavioral remediation may associated compensatory changes anchored lffg reflect atypically stronger coupling posterior visual regions lffgrmog greater functional segregation taskpositive tasknegative regions lffgrmpfc findings bolstered significant relationships strength identified functional connections literacy scores conclude examining ifc reveal cortical signatures dyslexia particular promise monitoring neural changes associated behavioral remediation