Alannah Stoneley, Judith Anderson, Clare Sutton
The Influence of Health Literacy and Self-Management on Emergency Healthcare Access for Rural Asthmatics: A Patient's Perspective
Cureus
surgical procedures impose hemostatic risk people hemophilia may minimized optimal factor f replacement therapy analysis evaluates efficacy safety extended halflife factor replacement recombinant fviii fix fc fusion proteins rfviiifc rfixfc surgery phase 3 pivotal alongkids along blongkids blong extension aspire byond studies dosing regimens determined investigators injection frequency dosing blood loss transfusions hemostatic response assessed fortyfive major n 31 subjects 90 minor n 70 subjects procedures performed hemophilia 35 major n 22 62 minor n 37 procedures performed hemophilia b unilateral knee arthroplasty common major orthopedic procedure hemophilia n 1534 hemophilia b n 824 day surgery median total dose adultsadolescents 81 iukg rfviiifc 144 iukg rfixfc major procedures required 2 injections including loading dose days 114 major procedures 1 injectionday hemostasis rated excellent rfviiifc n 3942 rfixfc n 2933 good n 342 n 433 evaluable major surgeries blood loss comparable subjects without hemophilia minor procedures adultsadolescents required one injection day surgery including median loading dose 51 iukg rfviiifc 80 iukg rfixfc major treatmentrelated safety concerns identified subjects developed inhibitors serious vascular thromboembolic events rfviiifc rfixfc efficacious well tolerated management perioperative hemostasis across wide spectrum major minor surgeries hemophilia