Kerry J. Ressler|Bekh Bradley|Kristina B. Mercer|Todd C. Deveau|Alicia K. Smith|Charles F. Gillespie|Charles B. Nemeroff|Joseph F. Cubells|Elisabeth B. Binder
Polymorphisms in <i>CRHR1</i> and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms
Howard Hughes Medical Institute|Emory University|Emory University|Atlanta VA Medical Center|Howard Hughes Medical Institute|Emory University|Emory University|Emory University|Emory University|Emory University|Emory University|Emory University|Max Planck Institute of Psychiatry
gene x environment g x e interactions mediating depressive symptoms separately identified stresssensitive serotonergic 5httlpr corticotropinreleasing hormone crhr1 systems objective examine whether effects child abuse moderated gene x gene g x g interactions crhr1 5httlpr polymorphisms used association study examining g x g x e interactions crhr1 5httlpr polymorphisms measures child abuse adult depressive symptomatology participant population n 1392 africanamerican low socioeconomic status 60 1000month family income high rates childhood lifetime trauma depressive symptoms measured beck depression inventory bdi history major depression structure clinical interview based dsmiv scid first replicated interaction child abuse 5httlpr lifetime scid diagnosis major depression subsample n 236 study populationthe largest africanamerican 5httlpr cohort reported date extended previously reported interaction crhr1 snp rs110402 tca haplotype interacting child abuse predict current symptoms n 1059 p 00089 found 5httlpr allele interacted crhr1 haplotypes child abuse predict current depressive symptoms n 856 p 0016 data suggest g x e interactions predictive depressive symptoms may differentially sensitive levels childhood trauma effects child abuse moderated genetic variation crhr1 5httlpr loci g x g interaction