Mehmet Top, Seda Sönmez, Hüseyin Aslan
An Evidence-Based Approach to Outcome Measurement in Oral and Dental Health Services: Oral Health-Related Quality of Life and Oral Health Impact
Worldviews on evidence-based nursing
using pooled vaginal microbiota data pregnancy cohorts n 683 participants environmental influences child health outcomes echo program analyzed 16s rrna gene amplicon sequences identify clinical demographic host factors associate vaginal microbiota structure pregnancy within across diverse cohorts using permanova models assessed factors associated vaginal community structure pregnancy examined whether host factors conserved across populations tested independent combined effects host factors vaginal community state types csts using multinomial logistic regression models demographic social factors explained larger amount variation vaginal microbiome pregnancy clinical factors adjustment lower education rather selfidentified race remained robust predictor l iners dominant cst iii diverse cst iv 844 95 ci 406176 418 95 ci 188926 respectively random forest models identified specific taxonomic features host factors particularly urogenital pathogens associated pregnancy complications aerococcus christensenii gardnerella spp among facultative anaerobes key markers community instability l iners sociodemographic factors robustly associated vaginal microbiota structure pregnancy considered sources variation human microbiome studies