Maíra Anelli Martins, Simone Aparecida Capellini
Identification of struggling readers or at risk of reading difficulties with one-minute fluency measures
Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS
widespread application highthroughput sequencing technology generated massive sequences bcell receptor bcr immune repertoires computational analysis data gained significant attention due increasing importance immunotherapy precision medicine reveals diversity dynamic changes immune responses contributing study associated diseases also provides valuable information immunodiagnostics drug development recently introduced bcrspecific multiple sequence alignment msa method along comprehensive platform software called abalign stands excellent choice analyzing bcr immune repertoires due unique highthroughput processing capability offers ultrafast msa functionality wide range analytical features including bcrantibody extraction clonal grouping lineage tree construction mutation profiling diversity statistics vj gene assignment antibody humanization importantly users perform analyses using graphical user interface without programming skills scripts article present series protocols integrate abaligns analysis modules cohesive workflow stepbystep workflow provides detailed instructions software installation data preparation comprehensive analysis bcr immune repertoires workflow facilitates efficient acquisition comprehensive results profiling bcr immune repertoires offering insights impacts infectious diseases allergies autoimmune disorders tumor immunology antibody drugs abalign freely available httpcaolabsharecnabalign 2024 wiley periodicals llc basic protocol 1 resource preparation basic protocol 2 analyzing bcr immune repertoires support protocol 1 aiding antibody humanization support protocol 2 constructing bcell lineage trees alternate protocol running linux command line basic protocol 3 comparing bcr immune repertoires