Maziah Mat Rosly
Are Malaysians Exercising? A Psychometric Analysis of Their Physical Activity Habits, Physical Literacy and Exercise Participation Rates among Adults with and without Disability
Behavioral sciences (Basel, Switzerland)
2021 european society cardiology prevention guidelines recommend use lifetime risk prediction models aid decisions regarding initiation prevention aimed update systematically recalibrate lifetimeperspective cardiovascular disease lifecvd model four european risk regions estimation lifetime cvd risk apparently healthy individuals updated lifecvd ie lifecvd2 models derived using individualparticipant data 44 cohorts 13 countries 687135 individuals without established cvd 30939 cvd events median 107 years followup lifecvd2 uses sexspecific functions estimate lifetime risk fatal nonfatal cvd events adjustment competing risk noncvd death systematically recalibrated four distinct european risk regions updated models showed good discrimination external validation among 1657707 individuals 61311 cvd events eight additional european cohorts seven countries pooled cindex 0795 95ci 07670822 predicted observed cvd event risks well calibrated populationwide electronic health records data uk cprd netherlands elan using lifecvd2 estimate potential gain cvdfree life expectancy preventive therapy projections varied risk region reflecting important regional differences absolute lifetime risk example 50yearold smoking woman sbp 140 mm hg estimated gain 09 years low risk region versus 16 years high risk region lifelong 10 mm hg sbp reduction benefit smoking cessation individual ranged 36 years low risk region 48 years high risk region taking account geographical differences cvd incidence using contemporary representative data sources recalibrated lifecvd2 model provides accurate tool prediction lifetime risk cvdfree life expectancy individuals without previous cvd facilitating shared decisionmaking cardiovascular prevention recommended 2021 european guidelines