Da Yan, Junyue Wang
Teaching data science to undergraduate translation trainees: Pilot evaluation of a task-based course
Frontiers in psychology
simple procedure selecting correct weighting factors linear quadratic calibration curves leastsquares regression algorithm bioanalytical lcmsms assays reported correct weighting factor determined relationship standard deviation instrument responses concentrations x weighting factor 1 1x 1x2 selected entire concentration range constant 2 proportional x proportional x respectively first time demonstrated detailed scientific reasoning solid historical data convincing justification 1x2 always used weighting factor bioanalytical lcmsms assays impacts using incorrect weighting factors curve stability data quality assay performance thoroughly investigated found stable curve could obtained correct weighting factor used whereas curves using incorrect weighting factors unstable also found insignificant impact concentrations reported calibration curves using incorrect weighting factors concentrations always reported passing curves actually overlapped close curves using correct weighting factor however use incorrect weighting factors impact assay performance significantly finally difference weighting factors 1x2 1y2 discussed findings generalized applied quantitative analysis techniques using calibration curves weighted leastsquares regression algorithm