Ilinca Tone, Amy Irwin
Watch Out for the Bull! Farmer Risk Perception and Decision-Making in Livestock Handling Scenarios
Journal of agromedicine
inherited cancer susceptibility often suspected absence significant cancer family history pathogenic germline variants pancreatic cancer wellstudied routine genetic testing recommended guidelines however data rare periampullary cancers pancreatic cancer insufficient compared prevalence germline susceptibility variants patients pancreatic cancer nonpancreatic periampullary cancers six hundred eight patients undergone pancreaticoduodenal resection tertiary referral hospital studied including 213 pancreatic ductal adenocarcinoma 172 ampullary cancer 154 distal common bile duct cancer 69 duodenal adenocarcinoma twenty cancer susceptibility candidate susceptibility genes sequenced variant interpretation assessed interrogating clinvar pubmed pathogenic likely pathogenic moderate highpenetrant germline variants identified 46 patients 77 including similar percentage patients pancreatic 85 nonpancreatic periampullary cancer 71 lowpenetrant variants identified additional 11 patients 18 eightynine percent moderate highpenetrant variants involved major cancer susceptibility genes brca2 atm brca1 cdkn2a msh2mlh1 palb2 remaining 11 involved cancer susceptibility genes brip1 bap1 msh6 almost pathogenic variant carriers family history cancer patients pancreatic nonpancreatic periampullary cancer similar prevalence pathogenic cancer susceptibility variants germline susceptibility testing considered patients periampullary cancer