Melissa Oldham, Emma Beard, Gemma Loebenberg, Larisa Dinu, Colin Angus, Robyn Burton, Matt Field, Felix Greaves, Matthew Hickman, Eileen Kaner, Susan Michie, Marcus Munafò, Elena Pizzo, Jamie Brown, Claire Garnett
Effectiveness of a smartphone app (Drink Less) versus usual digital care for reducing alcohol consumption among increasing-and-higher-risk adult drinkers in the UK: a two-arm, parallel-group, double-blind, randomised controlled trial
EClinicalMedicine
placement endotracheal tube children acute critical illness lowfrequency highrisk procedure associated high rates firstattempt failure adverse events including hypoxaemia reduce frequency adverse events provision oxygen patient apnoeic phase intubation proposed method prolong time available operator insert endotracheal tube prior onset hypoxaemia however limited data randomised controlled trials validate efficacy technique children technique known transnasal humidified rapid insufflation ventilatory exchange thrive uses high oxygen flow rates approximately 2 lkgmin delivered nasal cannulae apnoea shown least double amount time available safe intubation healthy children undergoing elective surgery technique application real time previously studied acutely ill injured children presenting emergency department admitted intensive care unit kids thrive trial multicentre international randomised controlled trial rct children less 16 years old undergoing emergent intubation either intensive care unit emergency department participating hospitals participants randomised receive either thrive intervention standard care apnoeic oxygenation intubation primary objective trial determine use thrive reduces frequency oxygen desaturation increases frequency firstattempt success without hypoxaemia emergent intubation children compared standard practice secondary objectives study assess impact use thrive rate adverse events length mechanical ventilation length stay intensive care paper describe detailed statistical analysis plan update previously published protocol