Weiguang Xie, Jingyi Xiao, Jingyi Chen, Hanzhong Huang, Xuehua Huang, Shaoyi He, Lin Xu
Impact of health education on promoting influenza vaccination health literacy in primary school students: a cluster randomised controlled trial protocol
BMJ open
studies established shortterm efficacy nirmatrelvirritonavir managing covid19 yet effect postcovid19 condition especially patients admitted hospital remains understudied study aimed examine effect nirmatrelvirritonavir postcovid19 condition among patients admitted hospital hong kong retrospective cohort study used realworld territorywide inpatient records vaccination records confirmed covid19 case data hong kong hospital authority department health government hong kong special administrative region patients aged 18 years older tested positive sarscov2 march 11 2022 oct 10 2023 admitted hospital covid19 included treatment group included patients prescribed nirmatrelvirritonavir within 5 days symptom onset excluding prescribed molnupiravir within 21 days control group exposure either nirmatrelvirritonavir molnupiravir outcomes postacute inpatient death 13 sequelae congestive heart failure atrial fibrillation coronary artery disease deep vein thrombosis chronic pulmonary disease acute respiratory distress syndrome interstitial lung disease seizure anxiety posttraumatic stress disorder endstage renal disease acute kidney injury pancreatitis outcomes evaluated starting 21 days positive rtpcr date respective cohort constructed outcome standardised mortality ratio weights applied balance covariates cox proportional hazards regression used investigate relationship nirmatrelvirritonavir outcomes 136 973 patients screened inclusion among 50 055 eligible included analysis 24 873 497 female 25 182 503 male 15 242 patients prescribed nirmatrelvirritonavir acute covid19 23 756 patients included control group 11 057 patients meet definition exposed unexposed groups patients followed median 393 days iqr 317489 nirmatrelvirritonavir group compared control group significantly lower hazard postacute inpatient death hazard ratio 062 95 ci 057068 p00001 congestive heart failure 070 058085 p00002 atrial fibrillation 063 052076 p00001 coronary artery disease 071 059085 p00002 chronic pulmonary disease 068 054086 p00011 acute respiratory distress syndrome 071 058086 p00007 interstitial lung disease 017 004075 p0020 endstage renal disease 037 018074 p00049 evidence indicating difference groups deep vein thrombosis seizure anxiety posttraumatic stress disorder acute kidney injury pancreatitis study showed extended benefits nirmatrelvirritonavir reducing risk postacute inpatient death well cardiovascular respiratory complications among patients admitted hospital covid19 research essential uncover underlying mechanisms responsible observed negative associations devise effective strategies preventing onset postacute sequelae health medical research fund research grants council themebased research schemes research grants council collaborative research fund