Brianne Bimson|Lois Brustman|Zainab Al Ibraheemi|Kimberly Herrera|Barak Rosenn
647: Can weekly vitamin d dosing adequately treat vitamin d deficiency in pregnancy?
Mount Sinai Hospital|Mount Sinai Hospital|Mount Sinai Hospital|Mount Sinai Hospital|Mount Sinai Hospital
individuals vitamin vd deficiency often treated weekly dose 50000 iu vd3 purpose study evaluate efficacy regimen pregnant women irb approved randomized doubleblind placebocontrolled study inclusion criteria vd 25ohd level 25ngml english spanish literacy age18 years gestational age20 weeks exclusion criteria included comorbidities medications interfere vd absorption metabolism use moodstabilizing medications women randomized 50000 iu vitamin d3 placebo week 8 weeks addition prenatal vitamin 400iu vitamin d3 vd levels obtained within 4 weeks study regimen completion delivery patients advised continue prenatal vitamins additional daily 400iu vd3 duration pregnancy using 2sided ttest 005 90 power 42 women required detect vd level difference 45 groups intentiontotreat analysis performed descriptive statistics chisquare 2sided ttest used indicated sixtyseven women vd deficiency randomized 36 treatment group tg 31 placebo group pg nine patients lost followup 4 tg 5 pg differences baseline demographics groups initial meansd vd levels 17637ngml 17141ngml tg pg respectively 8 weeks treatment vd levels 481196ngml 21159ngml pooo1 844 39 achieving vd sufficiency 30ngml tg pg respectively p0001 delivery vd levels 28898ngml 20589ngml tg pg respectively p00027 see figures 1 2 vd sufficiency delivery present 8 26 women available tg 6 25 women available pg statistically significant differences delivery outcomes antepartum maternal fetal complications weekly dosing 50000iu vd3 treat vd deficiency pregnancy effective safe promotes patient complianceview large image figure viewerdownload hires image download ppt