Timo Jaakkola, Sami Yli-Piipari, Mikko Huhtiniemi, Kasper Salin, Harto Hakonen, Arto Gråstén
Motor Competence and Health-related Fitness of School-Age Children: A Two-Year Latent Transition Analysis
Medicine and science in sports and exercise
previous studies suggest paliperidone might show better profile social functioning cognitive abilities risperidone aimed study whether switching risperidone paliperidone palmitate pp associated improved cognitive abilities 3 6 months switch thirtyeight patients dsmiv diagnosis schizophrenia studied patients treated oral risperidone risperidone longacting injection rlai indication switched pp psychiatrists statistical analyses conducted final sample 27 patients completed followup visits three assessments completed 1 baseline preswitch 2 3 months postswitch 3 6 months postswitch social functioning visit assessed personal social performance scale cognitive assessment conducted visit matrics consensus cognitive battery statistical analyses performed r linear mixed models used explore longitudinal changes social functioning cognitive outcomes psp scores significantly improved time switch risperidone pp sensitivity analysis found significant negative interaction time pp maintenance doses greater improvement patients receiving lower doses compared higher doses regarding longitudinal changes cognitive functioning patients improved 6 10 cognitive tasks involving processing speed working memory visual memory reasoning problem solving attention vigilance study suggests switching risperidone pp patients schizophrenia associated improvement social functioning cognitive performance