Graziano Onder|Tischa J. M. van der Cammen|Mirko Petrovic|Annemie Somers|C. Rajkumar
Strategies to reduce the risk of iatrogenic illness in complex older adults
Università Cattolica del Sacro Cuore|Brighton and Sussex Medical School|Delft University of Technology|Erasmus MC|Ghent University Hospital|Ghent University Hospital|Brighton and Sussex Medical School
older patients particularly vulnerable adverse drug reactions adrs age associated changes pharmacokinetics pharmacodynamics may alter drug metabolism addition conditions commonly observed older adults may increase risk adrs older population including polypharmacy comorbidity cognitive functional limitations adrs older adults frequently preventable suggesting screening prevention programmes aimed reducing rate iatrogenic illness necessary population present study reviews available approaches may used screen prevent occurrence adrs older adults including medication review avoiding use potentially inappropriate medications computerbased prescribing systems comprehensive geriatric assessment available evidence approaches mixed controversial none showed clear beneficial effect patients health outcomes limitation interventions lack standardisation differences may give reason variability results documented randomised clinical studies interestingly available research focused single intervention targeting either clinical pharmacological factors causing adrs approaches combined positive effects patients health outcomes shown suggesting integration skills different health care professionals needed address medical complexity older adults challenge future research integrate valuable information obtained existing instruments methodologies complete global approach targeting potential factors involved onset adrs