Ai Peng Tan|Zhen Ming Ngoh|Shayne Siok Peng Yeo|Dawn Xin Ping Koh|Peter D. Gluckman|Yap Seng Chong|Lourdes Mary Daniel|Anne Rifkin?Graboi|Marielle V. Fortier|Anqi Qiu|Michael J. Meaney
Left lateralization of neonatal caudate microstructure affects emerging language development at 24 months
National University Health System|Singapore Institute for Clinical Sciences|Agency for Science, Technology and Research|Agency for Science, Technology and Research|Singapore Institute for Clinical Sciences|Singapore Institute for Clinical Sciences|Agency for Science, Technology and Research|National University of Singapore|Singapore Institute for Clinical Sciences|Agency for Science, Technology and Research|Singapore Institute for Clinical Sciences|Agency for Science, Technology and Research|KK Women's and Children's Hospital|National University of Singapore|KK Women's and Children's Hospital|National University of Singapore|Singapore Institute for Clinical Sciences|Agency for Science, Technology and Research|National University of Singapore|Douglas Mental Health University Institute|McGill University
abstract complex interaction brain behaviour language disorder well established yet date imaging literature language disorder field continued pursue heterogeneous relatively small clinical crosssectional samples emphasis cortical structures volumetric analyses subcortical brain structures current work aimed go beyond state knowledge focus microstructural features subcortical brain structures specifically caudate nucleus large cohort neonates study association emerging language skills 24 months variations neonatal brain microstructure could interpreted proxy utero brain development language development highly dependent cognitive function home literacy environment also examined effect caudatelanguage function relationship utilizing conditional process model findings suggest emerging language development 24 months influenced degree left lateralization neonatal caudate microstructure indexed diffusion tensor imaging dtiderived fractional anisotropy fa fa indirect measure neuronal dendritic density within grey matter structures also found caudatelanguage function relationship partially mediated cognitive function conditional indirect effect left caudate fa language composite score cognitive function statistically significant low levels home literacy score 1 standard deviation sd authors proposed may related compensatory development cognitive skills less favourable home literacy environments