Dwayne Alleyne
The effect of discharge care plans on statin prescription rates
Journal of the American Association of Nurse Practitioners
observational studies reported gut microbiota composition associated metabolic syndrome however causal effect gut microbiota metabolic syndrome yet confirmed performed bidirectional mendelian randomization study investigate causal effect gut microbiota metabolic syndrome european population summary statistics gut microbiota largest available genomewide association study metaanalysis n 13266 conducted mibiogen consortium summary statistics outcome obtained comprehensive genomewide association studies metabolic syndrome n 291107 inversevariance weighted method applied primary method robustness results assessed series sensitivity analyses primary causal estimates actinobacteria 0935 95 ci 08780996 p 0037 bifidobacteriales 0928 95 ci 08680992 p 0028 bifidobacteriaceae 0928 95 ci 08680992 p 0028 desulfovibrio 0920 95 ci 08690975 p 0005 ruminococcaceaeucg010 0882 95 ci 08030969 p 0009 may associated lower risk metabolic syndrome lachnospiraceae 1130 95 ci 10161257 p 0025 veillonellaceae 1055 95 ci 10041108 p 0034 olsenella 1046 95 ci 10091085 p 0015 may linked higher risk metabolic syndrome reverse mr analysis demonstrated abundance ruminococcaceaeucg010 0938 95 ci 08860994 p 0030 may downregulated metabolic syndrome sensitivity analyses indicated heterogeneity horizontal pleiotropy mendelian randomization study provided causal relationship specific gut microbiota metabolic syndrome might provide new insights potential pathogenic mechanisms gut microbiota metabolic syndrome assignment effective therapeutic strategies