R F McCloy|Richard Stone
Science, medicine, and the future: Virtual reality in surgery
taurine amino acid plays important roles maintaining structural integrity function retina thus effects taurine taurine analogues combinations studied atpdependent calcium ion uptake system low calcium ion concentrations 10 microm rat retinal membrane preparation trans2aminocyclopentanesulfonic acid taps cyclic taurine analogue previously determined inhibit atpdependent calcium ion uptake demonstrated noncompetitive ki 0055 mm respect taurine values halfsaturation concentrations calculated varying concentrations taurine compared varying concentrations taurine presence fixed concentration taps 80 microm change however values maximal rates change significantly different 1234tetrahydroquinoline8sulfonic acid thqs less potent inhibitor atpdependent calcium ion uptake taps also shown noncompetitive taurine inhibition constant ki 238 mm thus presumed compounds taps thqs acting receptor sites taurine binding site taps thqs tested mixture maintains ratio fixed ratio mixture 1 part taps 25 parts thqs concentration mm varied wide range concentrations analyzed medianeffect plots equation inhibitory effects strongly synergistic shown combination index dosereduction index parallel nature medianeffect plots taps thqs indicates two inhibitors similar mode action mutually exclusive 3aminotetrahydrothiophene11dioxide ats piperidine3sulfonic acid psa agonist partial agonist demonstrated stimulatory effects atpdependent calcium ion uptake tested combination 11 taurine also determined mutually exclusive demonstrated ats taurine induced maximal rates change calcium ion uptake however psa less potent taurine combination taurine plus ats additive whereas combination taurine plus psa synergistic structureactivity relationships taurine analogues topological relationships discussed