Daniela Karine Ramos, Bruna Santana Anastácio, Gleice Assunção da Silva, Leila Urioste Rosso, João Mattar
Burnout syndrome in different teaching levels during the covid-19 pandemic in Brazil
BMC public health
154 million children hivexposed uninfected worldwide early child development crucially influences later academic socioeconomic factors however neurodevelopmental outcomes hivexposed uninfected heu children era maternal antiretroviral therapy art remain unclear aimed examine effects inutero exposure hiv art child neurodevelopment systematic review metaanalysis searched medline embase pubmed africawide information psycinfo global health databases inception may 27 2020 studies past two decades reporting neurodevelopment heu children aged 05 years compared hivunexposed hu children aim 1 effects different maternal art regimens neurodevelopment heu children aim 2 narrative syntheses aims randomeffects metaanalysis highquality studies comparing heu children hu children obtain weighted pooled estimates effect sizes study registered prospero crd42018075910 screened 35 527 records included 45 articles 31 studies overall 12 57 21 studies comparing heu children hu children found worse neurodevelopment heu children least one domain study design methodological quality variable heterogeneity across populations metaanalysis included eight highquality studies comparing 1856 heu children 3067 hu children ages 1224 months among heu children available data 1709 99 1732 exposed art heu children poorer expressive language effect size 017 95 ci 027 007 p00013 gross motor function 013 020 007 p00001 hu children similar cognitive development 006 019 006 p034 receptive language development 010 023 003 p014 fine motor skills 005 015 006 p036 results suggested little evidence effect specific maternal art regimens neurodevelopment study heterogeneity prevented metaanalysis heu children risk subtle impairments expressive language gross motor development age 2 years found consistent effect maternal art regimens analysed although evidence scarce highlight need large highquality longitudinal studies assess neurodevelopmental trajectories heu children investigate underlying mechanisms inform intervention strategies wellcome trust medical research council