Manuel B Garcia, Louis S Nadelson, Andy Yeh
"We're going on a virtual trip!": a switching-replications experiment of 360-degree videos as a physical field trip alternative in primary education
International journal of child care and education policy
earlylife stress els robustly associated range poor mental physical health outcomes recent studies implicate gut microbiome stressrelated mental cardiometabolic immune health problems research humans scarce thus far often based small selected samples often using retrospective reports els examined associations els human gut microbiome large populationbased study children els measured prospectively birth 10 years age 2004 children generation r study studied overall els well unique effects five different els domains including life events contextual risk parental risk interpersonal risk direct victimization stool microbiome assessed using 16s rrna sequencing age 10 years data analyzed multiple levels ie diversity indices individual genera predicted functional pathways addition explored potential mediators elsmicrobiome associations including diet age 8 body mass index 10 years associations observed overall els composite score five domains microbiome multiple testing correction contextual risk specific els domain related socioeconomic stress including risk factors financial difficulties low maternal education significantly associated microbiome variability els domain associated lower diversity diversity predicted functional pathways involved amongst others tryptophan biosynthesis associations part mediated overall diet quality proinflammatory diet fiber intake body mass index bmi results suggest stress related socioeconomic adversity overall early life stress associated less diverse microbiome general population association may part explained poorer diet higher bmi future research needed test causality establish whether modifiable factors diet could used mitigate negative effects socioeconomic adversity microbiome related health consequences