Selena Z. Kuo|Marta Haftek|Jennifer C. Lai
Factors Associated with Medication Non-adherence in Patients with End-Stage Liver Disease
University of California, San Francisco|University of California, San Francisco|University of California, San Francisco
low medication adherence known contribute worse health outcomes general population aimed evaluate medication regimen determine adherence levels among patients endstage liver disease measured adherence patients awaiting liver transplantation single center using 8item morisky medication adherence scale mmas8 score 8 classified low adherence medication regimen complexity assessed using medication regimen complexity index mrci tool factors associated low adherence identified logistic regression 181 patients 33 female median age 62 model endstage liver disease meld score 13 median iqr number medications 10 713 mrci 19 1327 total 54 30 high adherers 127 70 low adherers total 42 reported sometimes forgetting take medication 22 reported intermittent adherence within past 2 weeks common reasons low adherence forgetfulness 27 side effects 14 compared high adherence low adherence associated higher number medications medication complexity diabetes lower rates hepatocellular carcinoma selfperceived health univariable logistic regression total medication number 108 mrci 104 diabetes 238 hcc 038 lower selfperceived health 137 statistically significant factors associated nonadherence multivariate analysis medication number without supplements 114 remained significantly associated medication nonadherence majority patients awaiting liver transplantation demonstrated low medication adherence total number medications regimen complexity strong correlates low adherence data underscores need chronic liver disease management programs improve medication adherence vulnerable population