John Colombo|D. Jill Shaddy|Kathleen M. Gustafson|Byron Gajewski|Jocelynn M. Thodosoff|Elizabeth H. Kerling|Susan E. Carlson
The Kansas University DHA Outcomes Study (KUDOS) clinical trial: long-term behavioral follow-up of the effects of prenatal DHA supplementation
LifeSpan Medical Institute|University of Kansas|University of Kansas Medical Center|University of Kansas Medical Center|Imaging Center|University of Kansas Medical Center|University of Kansas Medical Center|University of Kansas Medical Center|University of Kansas Medical Center
docosahexaenoic acid dha longchain polyunsaturated fatty acid linked improved vision cognition postnatal feeding studies consistently associated reduction early preterm birth prenatal supplementation trials report first longterm followup infants mothers receiving prenatal dha supplementation us cohortour objective evaluate efficacy prenatal supplementation global granular longitudinal assessments cognitive behavioral developmentin randomized doubleblind clinical trial mothers received either 600 mgd dha placebo beginning 145 weeks gestation capsules provided delivery children pregnancies followed cognitive behavioral assessments administered 10 mo 6 age 301 mothers initial study 200 infants completed longitudinal schedulealthough intervention shown reduce highrisk pregnancies improve visual attention infants first year positive longterm effects prenatal dha supplementation emerged analyses followup increases maternal blood dha pregnancy related verbal full scale intelligence quotient iq scores 5 6 effects disappeared controlling ses maternal blood dha concentrations delivery unrelated outcomes although maternal dha enrollment related productive vocabulary 18 moalthough prenatal dha supplementation substantially reduced early preterm birth improved visual attention infancy sample consistent longterm benefits observed childhood increases maternal blood dha concentration pregnancy related higher iqs effect confounded ses disappeared ses statistically controlled trial registered httpwwwclinicaltrialsgov nct00266825 nct02487771