Michelle M. Langer|Myra I. Roche|Noel T. Brewer|Jonathan S. Berg|Cynthia M. Khan|Cristina Leos|Elizabeth Moore|Michelle Brown|Christine Rini
Development and Validation of a Genomic Knowledge Scale to Advance Informed Decision-Making Research in Genomic Sequencing
American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics|University of North Carolina at Chapel Hill|Pediatrics and Genetics|American Institutes for Research|American Institutes for Research|University of North Carolina at Chapel Hill|Pediatrics and Genetics
study evaluated psychometric properties new comprehensive measure knowledge genomic sequencing university north carolina genomic knowledge scale uncgksthe uncgks assesses knowledge four domains thought critical informed decision making genomic sequencing scale validated using classical test theory item response theory 286 adult patients 132 parents pediatric patients undergoing diagnostic whole exome sequencing wes ncgenes studythe uncgks assessed single underlying construct genomic knowledge good internal reliability cronbachs alpha 090 scores informative able discriminate individuals different levels genomic knowledge one standard deviation scale mean lower range included participants convergent validity supported associations health literacy numeracy rs041046 scale functioned well across subgroups differing sex raceethnicity education english proficiencyfindings supported promise uncgks valid reliable measure genomic knowledge among people facing complex decisions wes comparable sequencing methods neither disease populationspecific functioned well across important subgroups making usable diverse populations