Molly S. Bray|Ruth J.F. Loos|Jeanne M. McCaffery|Charlotte Ling|Paul W. Franks|George M. Weinstock|M Snyder|Jason L. Vassy|Tanya Agurs?Collins
NIH working group report—using genomic information to guide weight management: From universal to precision treatment
The University of Texas at Austin|Child Health and Development Institute|Icahn School of Medicine at Mount Sinai|Brown University|Miriam Hospital|Skåne University Hospital|Skåne University Hospital|Jackson Laboratory|Stanford University|Harvard University|Brigham and Women's Hospital|National Cancer Institute|National Institutes of Health
objective precision medicine utilizes genomic data optimize personalize treatment although 2500 genetic tests currently available largely extreme andor rare phenotypes question remains whether approach used treatment common complex conditions like obesity inflammation insulin resistance underlie host metabolic diseases methods review developed transnih conference titled genes behaviors response weight loss interventions provides overview state genetic genomic research area weight change identifies key areas future research results although many loci identified associated crosssectional measures obesitybody size relatively little known regarding genesloci influence dynamic measures weight change time although successful shortterm weight loss achieved using many different strategies sustainable weight loss proven elusive many important gaps understanding energy balance regulation conclusions elucidating molecular basis variability weight change potential improve treatment outcomes inform innovative approaches simultaneously take account information genomic sources devising individualized treatment plans