Paulina M Getsy, Gregory A Coffee, Walter J May, Santhosh M Baby, James N Bates, Stephen J Lewis
The Reducing Agent Dithiothreitol Modulates the Ventilatory Responses That Occur in Freely Moving Rats during and following a Hypoxic-Hypercapnic Challenge
Antioxidants (Basel, Switzerland)
functional magnetic resonance imaging fmri hemodynamic changes captured blood oxygen leveldependent bold response contains information brain activity bold response result complex neurovascular coupling comes least two fundamentally different forms positive negative deflection complexity signaling mathematical modelling provide vital help data analysis positive bold response plenty mathematical models physiological phenomenological however negative bold response physiologically based model exists expand previously developed physiological model prominent mechanistic hypothesis negative bold response neural inhibition hypothesis model trained tested experimental data containing negative positive bold responses two studies 1 visualmotor task 2 workingmemory task conjunction administration tranquilizer diazepam model able predict independent validation data used training provides mechanistic underpinning previously observed effects diazepam new model moves understanding negative bold response qualitative reasoning quantitative systemsbiology level useful basic research clinical use