Melissa Hawkins, Sarah Irvine Belson, Robin McClave, Lauren Kohls, Sarah Little, Anastasia Snelling
Healthy Schoolhouse 2.0 Health Promotion Intervention to Reduce Childhood Obesity in Washington, DC: A Feasibility Study
Nutrients
underrepresented subgroups biomarker research linked behavioral health trials may impact promise precision health mixed methods study examines biorepository donations across appalachian sample enrolled sugary drink reduction intervention trial participants enrolled behavioral trial asked join optional biomarker study tracked enrollment biospecimen returns stool andor buccal sample 6 months participants completed summative interview decisionmaking process experiences collecting samples recommendations encourage biospecimen donation return rates analyzed across demographics ie age gender race education income health literacy status rurality status using chisquares qualitative data content coded differences compared biomarker study enrollment donation choices 249 invited participants 171 61 enrolled 63 n 157 returned buccal samples 49 n 122 returned stool samples metro residing participants significantly likely 56 return stool samples compared nonmetro 39 counterparts x21 661 p 001 buccal sample return similar trend 67 57 respectively metro vs nonmetro x21 284 p 009 additional trend indicated older 40 years participants likely 55 donate stool samples younger 43 participants x21 339 p 007 demographics significantly associated biospecimen return qualitative data indicated societal 6681 personal 4151 benefits reported reasons deciding donate one samples whereas mistrust 311 negative perceptions collection process 4471 cited declined one samples clear instructions 60 simple collection kits 73 donation facilitators challenges included difficult stool collection kits 16 inconveniently located fedex centers 16 recommendations encourage future biorepository donation clarify benefits science others 58 provide commensurate incentives 25 explain purpose 19 privacy protections 20 assure ease sample collection 19 study findings suggest need biomarker research awareness campaigns researchers planning future biomarker studies medically underserved regions like appalachia may able apply findings optimize enrollment