Karen Ritchie|Isabelle Carrière|Craig Ritchie|Claudine Berr|Sylvaine Artéro|Marie-Laure Ancelin
Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
Neuropsychiatry Epidemiological and Clinical Research|Inserm|University of Montpellier|St Mary's Hospital|Neuropsychiatry Epidemiological and Clinical Research|Inserm|University of Montpellier|St Mary's Hospital|Neuropsychiatry Epidemiological and Clinical Research|Inserm|University of Montpellier|Neuropsychiatry Epidemiological and Clinical Research|Inserm|University of Montpellier|Neuropsychiatry Epidemiological and Clinical Research|Inserm|University of Montpellier
bobjectiveb estimate percentage reduction incidence dementia would obtained specific risk factors eliminated bdesignb prospective seven year cohort study bsettingb general population montpellier france bparticipantsb 1433 people aged 65 mean baseline age 725 sd 51 years bmain outcome measuresb diagnosis mild cognitive impairment dementia established standardised neurological examination bresultsb cox models constructed derive hazard ratios determine confounding interaction effects potentially modifiable risk factors dementia mean percentage population attributable fractions calculated 95 confidence intervals derived bootstrapping seven year incidence mild cognitive impairment dementia final model retained crystallised intelligence population attributable fraction 1811 95 confidence interval 1091 2542 depression 1031 366 1717 fruit vegetable consumption 646 015 1306 diabetes 488 187 798 apolipoprotein e 4 allele 711 244 1198 bconclusionsb increasing crystallised intelligence fruit vegetable consumption eliminating depression diabetes likely biggest impact reducing incidence dementia outweighing even effect removing principal known genetic risk factor although causal relations cannot concluded certainty study suggests priorities may inform public health programmes