Jose Eluf?Neto|Margaret Booth|Núbia Muñóz|F. Xavier Bosch|Chris J.L.M. Meijer|Jan M. M. Walboomers
Human papillomavirus and invasive cervical cancer in Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
hospitalbased casecontrol study undertaken examine role human papillomavirus hpv development invasive cervical cancer brazil study included 199 histologically confirmed incident cases 225 agefrequencymatched controls selected wide range diagnostic categories polymerase chain reaction technique used detect hpv dna cervical specimens collected spatula brush hpv dna detected 84 cases compared 17 controls grouping hpv types 16 18 31 33 66 cases positive compared 6 controls addition hpv number sexual partners early age first intercourse parity duration oral contraceptive use significantly associated increased risk cervical cancer history previous papanicolaou smears significantly associated decreased risk adjustment presence hpv dna parity history previous smears remained independent risk factors adjusted odds ratios cervical cancer associated hpv 16 18 31 33 697 95 confidence interval 2871696 unidentified types 120 51285 high risks found study implicate virus aetiology cervical cancer67 different types human papillomavirus hpv described 28 isolated benign malignant genital lesions good experimental data produced support etiological role hpv pathogenesis anogenital cancer especially cervical cancer leading cancer developing countries sao paolo brazil one highest incidence rates invasive cervical cancer worldwide authors therefore applied hospitalbased casecontrol study approach examine role hpv development disease brazil study included 199 histologically confirmed incident cases 225 agefrequencymatched controls selected wide range diagnostic categories hpv dna found cervical specimens via polymerase chain reaction technique 84 cases compared 17 controls grouping hpv types 16 18 31 33 66 cases positive compared 6 controls number sex partners early age first intercourse parity duration oral contraceptive use also significantly associated increased risk cervical cancer history previous papanicolaou smears significantly associated decreased risk adjustment presence hpv dna parity history previous smears remained independent risk factors adjusted odds ratios cervical cancer associated hpv 16 18 31 33 697 95 confidence interval 2871696 unidentified types 120 interval 51285 high risks therefore implicate hpv etiology cervical cancer