David J Klinke
In silico model-based inference: a contemporary approach for hypothesis testing in network biology
Biotechnology progress
patients obesity often experience psychological distress specifically depression symptoms due various barriers limitations healthcare offers digital interventions example medical apps provide suitable approach support affected people envisaged prospective randomized controlled trial aim examine efficacy lightmood intervention lightmood intervention manualized usercentered digital intervention patients obesity duration 4 months contains elements cognitive behavioral therapy mindfulnessbased skillsbased exercises expect lightmood intervention superior treatment usual tau terms reducing depression symptoms trial incorporates four distinct measurement time points baseline assessment posttreatment assessment 1 3month followup assessments furthermore implemented intreatment assessments groups participants randomized two groups lightmood intervention vs tau aim include 128 participants 64 per group study inclusion criteria patients obese least 18 years old private internet access adequate digital literacy show depression symptoms phq 10 exclusion criteria weekly outpatient individual psychotherapy obesity surgery within last year planned within next 7 months private internet access prescription new psychotropic drug within last 2 weeks primary outcome postassessment reduction depression symptoms secondary outcomes include improvement selfefficacy quality life mindfulness reduction eating disorder symptoms body mass index bmi furthermore expect positive development depression symptoms throughout different time points t1 t2 t3 patients obesity lightmood evidencebased efficient lowthreshold online intervention aims reduce depression symptoms people obesity online interventions could offer promising alternative conventional facetoface therapy primary objective current study add essential insight feasibility efficacy effectiveness acceptance emental health interventions people obesity depression symptoms german clinical trial register drks drks00029219 registered may 19 2023