Sabrina Awshah, Karina Bowers, Diane Threatt Eckel, Abdulrahman Fadi Diab, Samer Ganam, Joseph Sujka, Salvatore Docimo, Christopher DuCoin
Current trends and barriers to video management and analytics as a tool for surgeon skilling
Surgical endoscopy
bay 818973 kovaltry recombinant factor viii rfviii product efficacious well tolerated paediatric previously treated patients ptps severe haemophilia 50 exposure days eds leopold kids study longterm prophylaxis 100 eds provide substantial patient benefits fviii products demonstrate longterm safety efficacy demonstrate longterm 100 eds efficacy safety bay 818973 paediatric ptps ptps aged 12 years severe haemophilia without inhibitors could continue ongoing openlabel extension study completing 50 eds leopold kids main study patients received bay 818973 prophylaxis 2550 iukg 2week bleed treatment surgery bleeds documented electronic patient diaries inhibitor development monitored every 6 months august 2017 interim data cutoff 46 patients median range age enrolment 60 10110 years spent median range 6025 1481069 eds 46 1059 years main plus extension studies median quartile q1 q3 annualised bleeding rate bleeds within 48 h prophylaxis infusion total bleeds 10 02 19 20 04 36 respectively 94 bleeds mild moderate 718 treated 1 infusion bay 818973 also well tolerated one treatmentrelated adverse event transient lowtitre inhibitor require treatment adjustment bay 818973 efficacious prophylaxis treatment bleeds 45 years paediatric ptps severe haemophilia