Jonathan S Brumberg, Anh Nguyen, Kevin M Pitt, Sean D Lorenz
Examining sensory ability, feature matching and assessment-based adaptation for a brain-computer interface using the steady-state visually evoked potential
Disability and rehabilitation. Assistive technology
many alzheimers disease ad clinical trials failed demonstrate treatment efficacy cognition conceivable complex disease like ad may treatment effect due many heterogeneities disease processes individual traits employed individuallevel treatment response itr approach determine characteristics treatment responders estimated time saved cognitive decline using internetbased conversational engagement clinical trial iconect behavioral intervention study model iconect multisite singleblind randomized controlled trial aimed improve cognitive functions frequent conversational interactions via internetwebcam experimental group engaged video chats study staff 4 timesweek 6 months control group received weekly 10minute checkin phone calls 186 randomized participants current study used 139 participants complete information baseline 6month followup 73 mild cognitive impairment mci 66 normal cognition 64 experimental group 75 control group itr scores generated montreal cognitive assessment moca global cognition primary outcome category fluency animals cfa semantic fluency secondary outcome showed significant efficacy trial itr scores generated 300 iterations 3fold crossvalidated random forest models average treatment difference atd curve area curves abc estimated measure heterogeneity treatment responses responder traits identified using shapley additive explanations shap decision tree models time saved cognitive decline explored gauge clinical meaningfulness abc statistics showed substantial heterogeneity treatment response moca modest heterogeneity treatment response cfa age cognitive status time spent family friends education personality important characteristics influenced treatment responses intervention group participants upper 30 itr scores demonstrated potential delays 3 months semantic fluency cfa 6 months global cognition moca assuming 5fold faster natural cognitive decline compared control group posttreatment period itrbased analyses valuable profiling treatment responders features inform future trial design clinical practice reliably measuring time saved cognitive decline area ongoing research gain insight clinical meaningfulness treatment