Charles M. Giattino|Jeffrey R. Gardner|Faris M. Sbahi|Kenneth Roberts|Mary Cooter|Eugene W. Moretti|Jeffrey N. Browndyke|Joseph P. Mathew|Marty G. Woldorff|Miles Berger
Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults
Duke University|Duke University|Duke University Hospital|Duke Medical Center|Duke University|Duke Medical Center|Duke University Hospital|Duke Medical Center|Duke University Hospital|Duke Medical Center|Duke University Hospital|Duke Medical Center|Duke University|Duke University Hospital|Duke Medical Center
year 16 million older americans undergo general anesthesia surgery 40 develop postoperative delirium andor cognitive dysfunction pocd delirium pocd associated decreased quality life early retirement increased 1year mortality longterm cognitive decline multiple investigators thus suggested anesthesia surgery place severe stress aging brain patients less ability withstand stress increased risk developing postoperative delirium pocd delirium pocd risk increased patients lower preoperative cognitive function yet preoperative cognitive function routinely assessed intraoperative physiological predictors found correlate lower preoperative cognitive function since general anesthesia causes alphaband 812 hz electroencephalogram eeg power decrease occipitally increase frontally known anteriorization anestheticinduced frontal alpha power reduced older adults hypothesized lower intraoperative frontal alpha power might correlate lower preoperative cognitive function provide evidence correlation exists suggesting lower intraoperative frontal alpha power could used physiological marker identify older adults lower preoperative cognitive function lower intraoperative frontal alpha power could thus used target atrisk patients possible therapeutic interventions help prevent postoperative delirium pocd increased postoperative monitoring followup generally results suggest understanding interindividual differences brain responds anesthetic drugs used probe neurocognitive function dysfunction might useful measure neurocognitive function older adults