David S Tourigny
Dynamic metabolic resource allocation based on the maximum entropy principle
Journal of mathematical biology
pulsed field ablation pfa latest intriguing technology catheter ablation atrial fibrillation due capability generate irreversible cardiomyocytesselective electroporation cell membranes delivering microsecondlasting highvoltage electrical fields leading high expectations first trials assess clinical success pfa reported arrhythmiafree survival 1year 785 trials showed less enthusiastic results 662 paroxysmal 551 persistent af nevertheless real world data encouraging isolation pulmonary veins pfa easily achieved 100 acute success systematic invasive remapping showed high prevalence durable pulmonary vein isolation 75 90 days range 8496 significatively lower redo procedures 643 advent pfa prompting reconsideration role autonomic nervous system af ablation pfarelated sparing ganglionated plexi could lead still undetermined effect late arrhythmias recurrences moreover new concept blanking period could formulated pfa according different mechanism myocardial injury less inflammation less chronic fibrosis finally review also compare pfa thermal energy