Hannah R Thompson, Bhaani K Singh, Ana Ibarra-Castro, Gail Woodward-Lopez, Kristine A Madsen
Access to credentialed elementary physical education teachers in California and students' cardiorespiratory fitness
Preventive medicine
vasculogenic mimicry novel neovascularization pattern aggressive tumors associated poor clinical outcomes aim research establish new model termed vc score predict prognosis tumor microenvironment tme components immunotherapeutic response hepatocellular carcinoma hcc expression data public databases used develop prognostic model consensus clustering performed confirm molecular subtypes ideal clustering efficacy high lowrisk groups stratified utilizing vc score various methodologies including survival analysis singlesample gene set enrichment analysis ssgsea tumor immune dysfunction exclusion scores tide immunophenoscore ips nomogram utilized verification model performance characterize immune status hcc tissues gsea performed mine functional pathway information survival immune characteristics varied three molecular subtypes fivegene signature tpx2 cdc20 cfhr4 spp1 nqo1 verified function independent predictive factor prognosis patients hcc highrisk group exhibited lower overall survival os rates higher mortality rates comparison lowrisk group patients lowrisk group predicted benefit immune checkpoint inhibitor therapy exhibit increased sensitivity immunotherapy enrichment analysis revealed signaling pathways linked cell cycle dna replication processes exhibited enrichment highrisk group vc score holds potential establish individualized treatment plans clinical management strategies patients hcc