Monique C J Koks-Leensen, Anouk Menko, Fieke Raaijmakers, Gerdine A J Fransen-Kuppens, Kirsten E Bevelander
An Accessible Web-based Survey to Monitor the Mental Health of People with Mild Intellectual Disabilities and/or Low Literacy Skills during the COVID-19 Pandemic: Comparative Data Analysis
JMIR public health and surveillance
chlamydia trachomatis ct major outer membrane protein momp holds neutralising epitope variable domain 4 vd4 regions immune dominance infection well known study aimed assess antibody response induced infection compare specificity functionality response following vaccination vaccine cth522 contains vd4s serovars e f g assessed antibody epitopes momp high density peptide array furthermore role vd4 epitope neutralisation explored competitive inhibition experiments fusion protein holding neutralising vd4 linear epitope done two independent groups 1 momp seropositive individuals infected ct n 10 casecontrol study 2 cth522caf01vaccinated females n 14 chlm01 clinical trial identified major antigenic regions momp vd4 conserved region vd3 individuals infected ct regions addition vd1 identified vaccine recipients overall vd4 peptide responses uniform vaccinated individuals led inhibition infection vitro tested samples whereas vd4 responses heterogenous individuals infected ct 2 10 samples vd4mediated neutralising antibody responses data provide insights role antibodies momp vd4 induced infection vaccination show functionality differs induction functional vd4specific antibodies vaccine recipients mimics previous results animal models work supported european commission contract fp7health2011144280873 aditec fonden til lgevidenskabens fremme