Nick Glozier|Helen Christensen|Sharon L. Naismith|Nicole Cockayne|Liesje Donkin|Bruce Neal|Andrew Mackinnon|Ian B. Hickie
Internet-Delivered Cognitive Behavioural Therapy for Adults with Mild to Moderate Depression and High Cardiovascular Disease Risks: A Randomised Attention-Controlled Trial
University of Sydney|Black Dog Institute|University of Sydney|University of Sydney|University of Sydney|The George Institute for Global Health|University of Sydney|Orygen Youth Health|University of Melbourne|University of Sydney
mild moderate depression common cardiovascular disease undertreated aimed evaluate effectiveness internetdelivered cognitive behaviour therapy icbt depressive symptom severity adherence medical advice lifestyle interventions adults mild moderate depression high cardiovascular disease cvd risksrandomised doubleblind 12 week attentioncontrolled trial comparing icbt programme ecouch internetdelivered attention control health information package healthwatch n 282 primary outcome depression symptom level nineitem patient health questionnaire phq9 trial registration actrn12610000085077487562 88 participants completed endpoint assessment 383562 70 currently treated cardiovascular disease 314562 56 least one comorbid condition itt analysis 562 participants icbt produced greater decline mean phq9 score compared attention control 106 95 ci 023189 points differences two arms increasing intervention period time treatment effect interaction p 012 also larger improvements adherence 216 points 95 ci 033399 reductions anxiety 096 points 95 ci 019173 greater proportion engaging beneficial physical activity odds ratio 191 95ci 101361 icbt participants effect upon disability walking timeday withdrawals due study related adverse eventsin people mild moderate depression high levels cvd risk factors freely accessible icbt programme httpwwwecouchanueduau produced small robust improvement depressive symptoms adherence health behavioursaustralian new zealand clinical trials registry actrn12610000085077