Kim Edelstein|Brenda J. Spiegler|Shing Mi Ching Fung|Tony Panzarella|Donald Mabbott|Natalie Jewitt|Norma Mammone D’Agostino|W. P. Mason|Éric Bouffet|Uri Tabori|N. Laperriere|David Hodgson
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes
3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)|3M (United States)
treatment medulloblastoma childhood impairs neurocognitive function survivors diagnosed younger ages vulnerable little known longterm neurocognitive functional physical outcomes survivors approach middle age retrospective cohort study assessed 20 adults treated surgery radiotherapy medulloblastoma childhood median age assessment 219 years range 1847 years median time since diagnosis 155 years range 65422 years nine patients also underwent chemotherapy crosssectional analyses current neurocognitive functional physical status conducted data prior neuropsychological assessments available 18 subjects longitudinal analyses used model individual change time subjects group well average across multiple neurocognitive domains 90 required accommodations school learning disorders longer time since diagnosis age diagnosis associated continued decline working memory common sign aging younger age diagnosis associated lower intelligence quotient academic achievement scores even many years treatment completed common health complications survivors hearing impairment second cancers diabetes hypertension endocrine deficiencies adult survivors childhood medulloblastoma exhibit signs early aging regardless young diagnosis survival rates brain tumors continue improve neurocognitive physical sequelae may become evident survivors diagnosed different ages across lifespan become increasingly important identify factors contribute risk resilience growing population