Seda Ozkan, Esin Ceti Nkaya Uslusoy
Outcomes of jigsaw technique in nurse education: A systematic review and meta-analysis
Nurse education in practice
genomic studies pediatric cancer primarily focused specific tumor types highrisk disease used threeplatform sequencing approach including wholegenome sequencing wgs wholeexome sequencing wes rna sequencing rnaseq examine tumor germline genomes 309 prospectively identified children newly diagnosed 85 relapsedrefractory 15 cancers unselected tumor type eightysix percent patients harbored diagnostic 53 prognostic 57 therapeutically relevant 25 andor cancerpredisposing 18 variants inclusion wgs enabled detection activating gene fusions enhancer hijacks 36 8 tumors respectively small intragenic deletions 15 tumors mutational signatures revealing pathogenic variant effects evaluation paired tumornormal data revealed relevance tumor development 55 pathogenic germline variants study demonstrates power threeplatform approach incorporates wgs interrogate interpret full range genomic variants across newly diagnosed well relapsedrefractory pediatric cancers pediatric cancers driven diverse genomic lesions sequencing proven useful evaluating highrisk relapsedrefractory cases show combined wgs wes rnaseq tumor paired normal tissues enables identification characterization genetic drivers across full spectrum pediatric cancers article highlighted issue feature p 2945