Michael M. Ward
Psychological distress and changes in the activity of systemic lupus erythematosus
VA Palo Alto Health Care System|Stanford University
determine changes depressive symptoms anxiety lead changes activity systemic lupus erythematosus sletwentythree patients sle examined prospectively every 2 weeks 40 weeks assessment patients completed centers epidemiologic studiesdepression scale cesd state subscale statetrait anxiety inventory global assessment activity sle visual analogue scale sle activity also assessed visit physician global assessment systemic lupus activity measure slam systemic lupus erythematosus disease activity index sledai european consensus lupus activity measure eclamchanges depression anxiety positively correlated simultaneous changes patient global assessment sle activity slam changes physician global assessment sledai eclam depression anxiety scores also correlated patient global assessments slam scores 2 weeks later lagged scores significantly associated patient global assessment slam controlling current depression anxiety scores associations depression anxiety scores slam present slam scores modified exclude ratings depression fatigue measure sle activity increased 2 weeks immediately large increase cesd state anxiety scoresdepression anxiety scores parallel changes patients assessments activity sle found evidence support hypothesis psychological distress causes increased sle activity