Ozioma C. Okonkwo|Jennifer M. Oh|Rebecca L. Koscik|Erin M. Jonaitis|Caitlin A. Cleary|N. Maritza Dowling|Barbara B. Bendlin|Asenath LaRue|Bruce P. Hermann|Todd E. Barnhart|Dhanabalan Murali|Howard A. Rowley|Cynthia M. Carlsson|Catherine L. Gallagher|Sanjay Asthana|Mark A. Sager|Brad T. Christian|Sterling C. Johnson
Amyloid Burden, Neuronal Function, and Cognitive Decline in Middle-Aged Adults at Risk for Alzheimer's Disease
William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center
relative influence amyloid burden neuronal structure function prior cognitive performance prospective memory decline among asymptomatic late middleaged individuals risk alzheimers disease ad currently unknown investigated using longitudinal cognitive data 122 middleaged adults 21 decliners 101 stables enrolled wisconsin registry alzheimers prevention underwent multimodality neuroimaging 11cpittsburgh compound b pib 18ffluorodeoxyglucose fdg structuralfunctional magnetic resonance imaging fmri 57 14 years range 2989 baseline cognitive assessment covariateadjusted regression analyses revealed imaging measure significantly distinguished decliners stables p 027 neuronal function composite derived fdg fmri contrast several cognitive measures especially tap episodic memory significantly distinguished groups ps05 complementary receiver operating characteristic curve analyses identified brief visuospatial memory testrevised bvmtr total 82 05 p 001 bvmtr delayed recall 73 06 p 001 reading subtest widerange achievement testiii 72 06 p 002 top three measures best discriminated groups findings suggest early memory test performance might serve clinically pivotal role forecasting future cognitive course currently presumed