Joy D Scheidell, Tarlise N Townsend, Qinlian Zhou, Prima Manandhar-Sasaki, Ramon Rodriguez-Santana, Mark Jenkins, Marianne Buchelli, Dyanna L Charles, Jillian M Frechette, Jasmine I-Shin Su, R Scott Braithwaite
Reducing overdose deaths among persons with opioid use disorder in connecticut
Harm reduction journal
crosslinking mass spectrometry xlms evolved pivotal technique probing protein interactions study describes implementation parallel accumulationserial fragmentation pasef timstof instruments enhancing detection analysis protein interactions xlms addressing challenges xlms interpretation complex spectra low abundant crosslinked peptides data acquisition bias current study integrates peptidecentric approach analysis xlms data presents foundation integrating dataindependent acquisition dia xlms vendorneutral opensource platform novel workflow described processing datadependent acquisition dda pasefderived information software bruker daltonics used enabling conversion data format compatible merox skyline software tools approach significantly improves identification crosslinked products complex mixtures allowing xlms community overcome current analytical limitations