Pooja Rai, Jonas S Sundarakumar, Nimisha Basavaraju, Reddy Peera Kommaddi, Thomas Gregor Issac
Association between ApoE ε4 genotype and attentional function in non-demented, middle-aged, and older adults from rural India
Journal of neurosciences in rural practice
clinicians researchers regulators decisionmakers increasingly rely evidence realworld data rwd including data routinely accumulating health administrative databases rwd studies often rely algorithms operationalize variable definitions algorithm combination codes concepts used identify persons specific health condition characteristic establishing validity algorithms prerequisite generating valid study findings ultimately inform evidencebased health care paper aims systematize terminology methods practical considerations relevant conduct validation studies rwdbased algorithms discuss measures algorithm accuracy goldreference standard study size prioritizing accuracy measures algorithm portability implication interpretation information bias common epidemiologic studies underscoring importance transparency decisions regarding choice prioritizing measures algorithm validity validity algorithm judged context data source one size fit prioritizing validity measures within given data source depends role given variable analysis eligibility criterion exposure outcome covariate validation work part routine maintenance rwd sources