Felicity A S Bright, Claire Ibell-Roberts, Katie Featherstone, Nada Signal, Bobbie-Jo Wilson, Aileen Collier, Vivian Fu
Physical well-being is our top priority': Healthcare professionals' challenges in supporting psychosocial well-being in stroke services
Health expectations : an international journal of public participation in health care and health policy
multiple drug allergy multiple drug intolerance syndrome mdasmdis labels impediment clinical care knowledge regarding conditions limited systematic review investigated characterization epidemiology risk factors clinical impact pharmacoeconomics mdas mdis systematic literature search across 11 databases 01 january 200006 november 2020 mdis mdas related terminology studies reviewed quality evidence risk bias employing critical appraisal skills programme cohort study checklist narrative synthesis approach facilitated systematic textual descriptions tabulation thematic analysis adopted heterogeneity terminology methodology studies applied standard drug allergy diagnostic methods evidence suggest multiple drug hypersensitivity syndrome mdhs ie confirmed allergies mdas distinct clinical entity prevalence mdis mdas labels unselected selected populations varied 2164 4990 12 036 respectively reported risk factors included female gender increasing age body mass index anxiety depression comorbidities concurrent allergies increased healthcare utilization drugs commonly implicated antibiotics nonsteroidal antiinflammatory drugs studies relating clinical impact pharmacoeconomics found considerable burden mdas mdis labels data needs cautious interpretation majority studies described involved unverified labels despite limitation heterogeneity studies evidence suggest mdhs distinct clinical entity welldesigned multicentre studies applying standardized terminology diagnostic methodology needed gain insight conditions