Caterina Rosano|Howard J. Aizenstein|Anne B. Newman|Vijay Venkatraman|Tamara B. Harris|Jingzhong Ding|Suzanne Satterfield|Kristine Yaffe
Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year period
University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|National Institute on Aging|Wake Forest University|University of Tennessee Health Science Center|University of California, San Francisco
maintaining cognitive function protects older adults developing functional decline study aims identify neuroimaging correlates maintenance higher global cognition measured modified mini mental state test 3ms score repeated 3ms measures 199798 200607 magnetic resonance imaging diffusion tensor 200607 obtained biracial cohort 258 adults free dementia mean age 829 years 56 women 42 blacks participants classified shown either maintenance 3ms slope 0 decline 3ms slope 1 sd mean cognition using linear mixed models measures interest white matter hyperintensity volume wmhv total brain volume gray matter gmv microstructure mean diffusivity md total brain brain areas known related memory executive control function medial temporal area hippocampus parahippocampus entorhinal cortex cingulate cortex dorsolateral prefrontal posterior parietal cortex differences cognitive maintainers n 153 nonmaintainers n 107 significant gmv medial temporal area 358 p 0004 lower md cingulate cortex 379 p 0008 neuroimaging markers multivariable regression models adjusted age race wmhv gmv total brain vascular conditions standard deviation gmv medial temporal area standard deviation md cingulate cortex associated nearly 4 times greater probability odds ratio standard deviation 380 116 1244 34 lower probability 066 046 097 maintaining cognitive function respectively models neither wmhv gmv total brain significantly associated probability maintaining cognitive function preserving volume medial temporal area microstructure cingulate cortex may contribute maintaining cognitive function late life