Flávia Barreto Garcez|Márlon Juliano Romero Aliberti|Paula Cristina Eiras Poco|Marcel Hiratsuka|Silvia de Fatima Takahashi|Venceslau A. Coelho|Danute Bareisys Salotto|Marlos Luiz Villela Moreira|Wilson Jacob?Filho|Thiago Junqueira Avelino?Silva
Delirium and Adverse Outcomes in Hospitalized Patients with <scp>COVID</scp>?19
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo|Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
little known association acute mental changes adverse outcomes hospitalized adults covid19to investigate occurrence delirium hospitalized patients covid19 explore association adverse outcomeslongitudinal observational studytertiary university hospital dedicated care severe cases covid19 paulo brazila total 707 patients aged 50 years older consecutively admitted hospital march may 2020we completed detailed reviews electronic medical records collect data identified delirium occurrence using chartbased delirium identification instrument chartdel trained physicians background geriatric medicine completed chartdel assessments complemented baseline clinical information using telephone interviews participants proxy outcomes interest inhospital death length stay admission intensive care ventilator utilization adjusted multivariable analyses age sex clinical history vital signs relevant laboratory biomarkers lymphocyte count creactive protein glomerular filtration rate ddimer albuminoverall identified delirium 234 participants 33 admission 86 12 delirious observed 273 deaths 39 sample inhospital mortality reached 55 patients experienced delirium delirium associated inhospital death adjusted odds ratio 175 95 confidence interval 115266 association held middleaged older adults delirium also associated increased length stay admission intensive care ventilator utilizationdelirium independently associated inhospital death adults aged 50 years older covid19 despite difficulties patient care pandemic clinicians routinely monitor delirium assessing severity prognosis covid19 patients