Suchita A Lorick, Lisa Goldberg, Fan Zhang, Nancy Birkhimer, Nancy Dube, Kay Dutram, Teresa Hubley, Meredith Tipton, Ricardo Basurto-Davila, Sam Graitcer, Dora Anne Mills
Factors associated with uptake of the Influenza A(H1N1)pdm09 monovalent pandemic vaccine in K-12 Public Schools, Maine 2009-2010
Journal of public health management and practice : JPHMP
singlepollutant models linked prenatal pm25 exposure lower birthweight however analyzing air pollutant mixtures better captures pollutant interactions total effects unfortunately strong correlations pollutants restrict traditional methods explored association exposure mixture air pollutants different gestational age windows pregnancy birthweight included 4635 motherinfant dyads new york state birth cohort born 20082010 air pollution data sourced epas community multiscale air quality model matched census tract centroid maternal home address birthweight gestational age extracted vital records applied linear regression study association prenatal exposure pm25 pm10 nox so2 co birthweight six sensitive windows utilized bayesian kernel machine regression examine nonlinear effects interactions within fivepollutant mixture final models adjusted maternal sociodemographics infant characteristics seasonality singlepollutant linear regression models indicated pollutants associated decrement birthweight specifically twoweek window birth interquartile range increase pm25 exposure iqr 33 gm3 median window correlated 34 g decrement birthweight 95 ci 54 14 followed so2 iqr 20 ppb 31 pm10 iqr 46 gm3 29 co iqr 608 ppb 27 nox iqr 79 ppb 26 multipollutant bkmr models revealed pm25 nox co exposure negatively nonlinearly linked birthweight fivepollutant mixture increased birthweight decreased median level exposure prenatal exposure air pollutants notably pm25 final two weeks pregnancy may negatively impact birthweight nonlinear relationships air pollution birthweight highlight importance studying pollutant mixtures interactions