Lichao Sun, Xiaoyan Ma, Zhenya Chen, Qin Zou, Yixin Huo
[Interdisciplinary teaching-assisted education reform in "Principal Biology"]
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
taiwan deeply impacted 2003 sars outbreak promptly implemented rigorous infection control prevention icp measures january 2020 combat global covid19 pandemic crosssectional serologic study conducted among healthcare workers hcws tertiary care hospital taiwan august 1 2022 february 28 2023 study aimed assess hcws antibody responses covid19 vaccination omicron subvariants ba1 ba4 ba5 considering variations prior infection additionally evaluated effectiveness icp vaccination policies within hospital setting taiwan crosssectional serology study conducted taiwan investigate seroprevalence rates omicron subvariants ba1 ba4 ba5 among hcws total 777 hcws participated study structured questionnaire collected obtain epidemiological characteristics risk factors potential exposure enzymelinked immunosorbent assay used detect antibody responses serum samples selected protection omicron subvariants ba1 ba4 ba5 using pseudotypedbased neutralization assay 99 participants received sarscov2 vaccination overall 577 infected sarscov2 asymptomatic sarscov2 antispike s1 protein igg antis distribution 40000 auml 202 157777 participants mean standard deviation 23442 22086 decay curve antis less 20000 auml 120 days probability curve 50 neutralization showed antis 55000 auml optimum antis 41328 auml equal 5869 whos standard bauml 861 sensitivity 635 specificity significant study 202 hcws achieved seroprotection omicron subvariants ba1 ba4 ba5 immunity omicron subvariants reinforced recommended vaccinations development natural immunity sarscov2 exposure collectively enhancing protection omicron