Angela J. Marlow|Simon E. Fisher|Alex Richardson|Clyde Francks|Joel B. Talcott|Anthony P. Monaco|John Stein|Lon R. Cardon
Investigation of quantitative measures related to reading disability in a large sample of sib-pairs from the UK.
University of Oxford|Wellcome Centre for Human Genetics|Wellcome Centre for Human Genetics|University of Oxford|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford|University of Oxford|Wellcome Centre for Human Genetics|University of Oxford
describe familybased sample individuals reading disability collected part quantitative trait loci qtl mapping study eightynine nuclear families 135 independent sibpairs identified single proband using traditional discrepancy score predictedactual reading ability known family history eight correlated psychometric measures administered sibling including single word reading spelling similarities matrices spoonerisms nonword irregular word reading pseudohomophone test summary statistics measure showed reduced mean probands compared cosibs turn lower population partial cosib regression back mean indicates measures influenced familial factors therefore may suitable mapping study variance measures remained largely unaffected reassuring application qtl approach multivariate genetic analysis carried explore relationship measures identified common factor reading measures accounted 54 variance finally familiality estimates range 032073 obtained reading measures including common factor 068 supported heritability findings demonstrate viability sample qtl mapping assist interpretation subsequent linkage findings ongoing genome scan