Giuseppe Alessandro Veltri, Janina Isabel Steinert, Henrike Sternberg, Matteo M Galizzi, Barbara Fasolo, Ploutarchos Kourtidis, Tim Büthe, George Gaskell
Assessing the perceived effect of non-pharmaceutical interventions on SARS-Cov-2 transmission risk: an experimental study in Europe
Scientific reports
collective dynamics multicellular systems biological organs tissues plays key role biological development regeneration pathological conditions collective tissue dynamicsunderstood population behaviour arising interplay constituting discrete cellscan studied offlattice agentbased models however classical onlattice agentbased models also known cellular automata fail replicate key aspects collective migration central instance collective behaviour multicellular systems overcome drawbacks classical onlattice models introduce onlattice agentbased modelling class collective cell migration call biological latticegas cellular automaton biolgca biolgca characterised synchronous time updates explicit consideration individual cell velocities rules classical cellular automata typically chosen ad hoc rules cellcell cellenvironment interactions biolgca also derived experimental cell migration data biophysical laws individual cell migration introduce elementary biolgca models fundamental cell interactions may combined modular fashion model complex multicellular phenomena exemplify mathematical meanfield analysis specific biolgca models allows explain collective behaviour first example predicts formation clusters adhesively interacting cells second example based novel biolgca combining adhesive interactions alignment model analysis clarifies nature recently discovered invasion plasticity breast cancer cells heterogeneous environments