Diane R. Blake|Celeste A. Lemay|Louise Maranda|J. Dennis Fortenberry|Margaret H. Kearney|Kathleen M. Mazor
Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial
University of Massachusetts Chan Medical School|University of Massachusetts Chan Medical School|University of Massachusetts Chan Medical School|Indiana University – Purdue University Indianapolis|University of Rochester|University of Massachusetts Chan Medical School
hiv vaccine trials minors likely require parental permission informed assent adolescents valid process information needs presented manner promotes adolescent comprehension previous studies suggest adolescent comprehension assent often insufficient developed interactive webbased assent included interspersed quiz questions hypothetical hiv vaccine trial efficacy webbased assent compared standard paper assent without interspersed questions one hundred twenty teen participants ages 1517 years five community organizations randomized selfadministered webbased assent n 60 investigatoradministered paper assent n 29 without n 31 interspersed quiz questions reviewing assent participants completed 27item comprehension test comprehension scores compared groups mean number correctly answered questions 212 full paper group 211 webbased group t118 008 p 094 scores 202 paper without interspersed questions subgroup 221 paper interspersed questions subgroup t58 196 p 0055 participants webbased group performed well comprehension test paper group paper questions subgroup performed better paper without questions subgroup suggesting interspersed quiz questions may improve understanding traditional paper assent minimal investigator time standardized administration webbased assent well ability tailor assent discussion topics identified incorrect comprehension test responses advantages worthy investigation