Anja Soldan|Corinne Pettigrew|Shanshan Li|Mei Cheng Wang|Abhay Moghekar|Ola A. Selnes|Marilyn Albert|Richard O’Brien
Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease
Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University
levels amyloid phosphorylated tau ptau measured cerebrospinal fluid associated risk progressing normal cognition onset clinical symptoms preclinical alzheimers disease examined whether cognitive reserve cr modifies association cerebrospinal fluid obtained baseline 239 participants mean age 572 years followed 17 years clinical cognitive assessments mean followup 8 years composite score based national adult reading test vocabulary years education baseline used index cr cox regression models showed increased risk progressing normal cognition symptom onset associated lower cr lower baseline higher baseline ptau interaction cr suggesting protective effects higher cr equivalent across observed range amyloid levels contrast tau ptau interacted cr indicating cr protective lower levels tau ptau