Shelley I Gray, M Jeanne Wilcox, Mark Reiser
Efficacy of the Teaching Early Literacy and Language Curriculum With Preschoolers From Low-Income Families
Language, speech, and hearing services in schools
study aimed investigate potential mediating role neurofilament light chain nfl level depressive symptoms cognitive function older population total 495 adults age 60 years national health nutrition examination survey nhanes participated study cognitive function assessed using combination animal fluency test aft consortium establish registry alzheimers disease cerad digit symbol substitution test dsst word list learning test patient health questionnaire9 phq9 used assess depressive symptoms data serum nflsnfl collected multiple linear regressions mediation analysis utilized examine associations adjusting potential confounding factors proportions mediated snfl level depressive symptoms cognitive function 1965 indirect effect mediated snfl level depressive symptoms cognitive function significant 95 ci00089 00191 00017p 0040 direct effect absence snfl nonsignificant 95 ci 00365 00739 00008p 0055 explorative crosssectional study limits generalizability ability establish definitive causal associations results interpreted caution due constraints imposed characteristics population relatively low overall level depressive symptoms snfl level depressive symptoms cognitive decline interconnected snfl level could mediate relationship depressive symptoms cognitive decline among older adults