Lars Bygren|Petter Tinghög|John Carstensen|Sören Edvinsson|Gunnar Kaati|Marcus Pembrey|Michael Sjöstróm
Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren
Karolinska Institutet|Karolinska Institutet|Linköping University|Umeå University|Karolinska Institutet|University College London|Karolinska Institutet
study investigated whether large fluctuations food availability grandparents early development influenced grandchildrens cardiovascular mortality reported earlier changes availability food good poor poor good intrauterine development followed double risk sudden death adult mortality rate associated ancestors childhood availability food studied transgenerational responses tgr sharp differences harvest two consecutive years ancestors 317 people verkalix sweden confidence intervals wide found striking tgr response cardiovascular mortality grandchild sharp changes early exposure experienced three four grandparents maternal grandparents paternal grandfathers however paternal grandmother puberty lived sharp change food supply one year next sons daughters excess risk cardiovascular mortality hr 269 95 confidence interval 105692 selection learning imitation unlikely explanations xlinked epigenetic inheritance via spermatozoa seemed plausible transmission limited father possibly explained sex differences meiosis shock change food availability seems give specific transgenerational responses