Sandeep Rai|Bidhubhusan Mahapatra|Subhashish Sircar|Pinnamaneni Yujwal Raj|Srinivasan Venkatesh|Mohammed Shaukat|B. B. Rewari
Adherence to Antiretroviral Therapy and Its Effect on Survival of HIV-Infected Individuals in Jharkhand, India
Population Council|Government of India|Ministry of Health and Family Welfare|Government of India|Ministry of Health and Family Welfare|Government of India|Ministry of Health and Family Welfare|Government of India|Ministry of Health and Family Welfare
introduction research india extensively examined factors associated nonadherence antiretroviral therapy art limited focus examining relationship adherence art regimen survival status hiv infected patients study examines effect optimal adherence art survival status hiv infected patients attending art centers jharkhand india materials methods data cohort 239 hiv infected individuals initiated art 2007 compiled medical records retrospectively 36 months sociodemographic characteristics cd4 cell count presence opportunistic infections time art initiation art regimen intake survival status collected periodically optimal adherence assessed using pill count methods patients took 95 specified regimens identified nonadherent coxproportional hazard model used determine relative hazards mortality results threefourths patients male average 34 year old median cd4 cell count 118 cellscmm time art registration 57 patients registered art found adherent art total 104 patients died 3585 patientyears observation resulting mortality rate 29 per 100 patientyears 95 confidence interval ci 239352 median survival time 65 months ci 27109 mortality rate higher among patients nonadherent art 645 ci 505824 adherent 154 ci 113210 risk mortality fourfold higher among individuals nonadherent art adherent adjusted hazard ratio 39 ci 2660 conclusion adherence art associated higher chance survival hiv infected patients ascertaining need interventions improve art adherence early initiation art