Xiaoying Xia
Parenting style and Chinese preschool children's pre-academic skills: A moderated mediation model of approaches to learning and family socioeconomic status
Frontiers in psychology
patients covid19 broad panels immune checkpoint molecules icpms purinergic signaling studied parallel aimed perform indepth immunophenotyping major cell subsets present human peripheral blood covid19 patients controls using pd1 tim3 lag3 tigit cd200r well cd39 markers purinergic signaling pathway studied 76 covid19 patients 12 healthy controls using peripheral blood mononuclear cells flow cytometry univariable multivariable statistics performed icpms studied significantly overexpressed different cell subsets covid19 patients compared healthy controls elevated lactate dehydrogenase creactive protein age high expression cd45 cd39cd45 tim3cd39cd4cd45 tim3cd39cd8cd3cd4 cells significantly associated severe covid19 multivariable analysis however high expression cd39cd45 514 95 ci 15 1763 tim3cd39cd4cd3cd45 226 95 ci 18 277 cells independent predictor severe covid19 conclusion numerous icpms overexpressed covid19 patients compared healthy controls suggesting pathophysiological role molecules sarscov2 infection however tim3 coexpression cd39 remained significant independent prognostic icpm multivariable analysis flow cytometric evaluation tim3cd39cd4cd3cd45 well cd39cd45 powerful tool prognostication covid19 patients hospital admission