Jan Håkon Rudolfsen, John Vissing, Ulla Werlauff, Charlotte Olesen, Niels Illum, Jens Olsen, Peter Bo Poulsen, Mette Strand, Alfred Peter Born
Burden of Disease of Duchenne Muscular Dystrophy in Denmark - A National Register-Based Study of Individuals with Duchenne Muscular Dystrophy and their Closest Relatives
Journal of neuromuscular diseases
embryo culture media used ivficsi treatment effect cognitive development singleton ivf children 9 years age cognitive development children born culture two different embryo culture media comparable previously shown culture medium used ivficsi treatment affects birthweight weight 2 years age alternating assignment embryo culture either kscicm cook g1 version 3 vitrolife children low birthweight known increased risk learning disabilities data cognitive development general children born art still conflicting study reporting effects culture medium cognitive development shows significant differences cognitive development two culture medium groups observational cohort followup study mediumkids parents singletons abovementioned study approached ninth birthday child participate additional followup study 294 eligible children included original study 119 children 70 vitrolife 49 cook participated current study followup measurements performed march 2014 december 2016 cito dutch central institute test development developed dutch pupil monitoring system involves nationwide independent standardized academic achievement score tests monitor childs school performance twice year fixed time points third grade onward tests include language skills vocabulary orthography mathematics reading capability comprehension results tests performed third sixth grades expressed ability scores obtained school investigate school performance development years used mixed effects multilevel model least complex model best fit selected analyze whether culture medium affects cognitive development cohort study enough power detect difference ability score reflects least one performance category two groups differences seen baseline characteristics participants nonparticipants parental children characteristics domains random intercept model used analyses showed comparable results two culture medium groups significant differences observed cognitive development domains even correction potential confounders parental level education higher ivf group 45 compared national average level education 35 likely explains higher cito scores ivf children compared national ability scores limitation study pseudorandomized design relatively low participation rate 405 number missing data prevent us drawing robust causal conclusions however first therewith oldest cohort children culture medium allocated alternatingly used blinded setting period conditions identical study gives best available evidence study analyzes effects culture medium school performance children born ivficsi prospective cohort study although research longterm academic skills also behavior essential results reassuring make parents children born ivficsi feel comfortable childrens cognitive development study financially supported march dimes grant 6fy13153 sponsor study role study design data collection data analysis data interpretation writing report authors conflicts interest declare ntr4220