Catherine Limperopoulos|Gevorg Chilingaryan|Nancy Sullivan|Nicolas Guizard|Richard L. Robertson|Adré J. du Plessis
Injury to the Premature Cerebellum: Outcome is Related to Remote Cortical Development
Children's National|George Washington University|Jewish Rehabilitation Hospital|Montreal Neurological Institute and Hospital|Boston Children's Museum|Children's National
cerebellar injury important complication preterm birth farreaching neuropsychiatric sequelae previously shown significant association isolated injury premature cerebellum subsequent impairment regional volumetric growth contralateral cerebrum current study examine relationship remote regional impairments cerebral volumetric growth domainspecific functional deficits children 40 expreterm infants isolated cerebellar injury performed neurodevelopmental evaluations quantitative magnetic resonance imaging mri studies mean age 34 months measured cortical gray matter volumes 8 parcellated regions cerebral hemisphere well right left cerebellar volumes show highly significant associations early signs autism dorsolateral prefrontal cortex volume p 0001 gross motor scores sensorimotor cortical volumes p 0001 cognitive expressive language scores premotor midtemporal cortical volumes p 0001 multivariate analyses unit increase corresponding regional cerebral volume associated lower odds abnormal outcome score adjusted age mri contralateral cerebellar volume first report linking secondary impairment remote cerebral cortical growth functional disabilities survivors prematurityrelated cerebellar brain injury