Zinabu Bekele Tadese, Araya Mesfin Nigatu, Tirualem Zeleke Yehuala, Yakub Sebastian
Prediction of incomplete immunization among under-five children in East Africa from recent demographic and health surveys: a machine learning approach
Scientific reports
international iga nephropathy prediction tool iiganpt predict risk endstage renal disease esrd estimated glomerular filtration rate egfr decline 50 adult igan patients considering differential progression older adult adult patients study aims externally validate performance older adult cohort analyzed 165 igan patients aged 60 six medical centers categorizing predicted risk primary outcome 50 reduction estimated glomerular filtration rate egfr kidney failure evaluation models involved concordance statistics cstatistics timedependent receiver operating characteristic roc curves kaplanmeier survival curves calibration plots comparative reclassification conducted using net reclassification improvement nri integrated discrimination improvement idi study included 165 chinese patients median age 64 60 male median followup 51 years 21 reached primary outcome models without race demonstrated good discrimination cstatistics 0788 0790 respectively survival curves risk groups wellseparated full model without race accurately predicted 5year risks whereas full model race tended overestimate risks 3 years significant reclassification improvement noted full model without race nri 009 95 ci 027 034 idi 0003 95 ci 0009 0019 models exhibited excellent discrimination among older adult igan patients full model without race demonstrated superior calibration predicting 5year risk