Karine Manera|Allison Tong|Jonathan C. Craig|Jenny I. Shen|Shilpanjali Jesudason|Yeoungjee Cho|Bénédicte Sautenet|Armando Teixeira?Pinto|Martin Howell|Angela Wang|Edwina A. Brown|Gillian Brunier|Jeffrey Perl|Jie Dong|Martin Wilkie|Rajnish Mehrotra|Roberto Pecoits–Filho|Saraladevi Naicker|Tony Dunning|Nicole Scholes?Robertson|David W. Johnson
An international Delphi survey helped develop consensus-based core outcome domains for trials in peritoneal dialysis
Patient-Centered Outcomes Research Institute
shared decisionmaking clinical care options endstage kidney disease limited inconsistencies reporting outcomes omission patientimportant outcomes trials generated consensusbased prioritized list outcomes reported trials peritoneal dialysis pd international online threeround delphi survey patientscaregivers health professionals rated importance outcomes using 9point likert scale 79 indicating critical importance provided comments using bestworst scale bws relative importance outcomes estimated comments analyzed thematically total 873 participants 207 patientscaregivers 666 health professionals 68 countries completed round one 629 completed round two 530 completed round three top outcomes pdrelated infection membrane function peritoneal dialysis failure cardiovascular disease death catheter complications ability usual activities compared health professionals patientscaregivers gave higher priority six outcomes blood pressure mean difference 04 fatigue 03 membrane function 03 impact familyfriends 01 peritoneal thickening 01 usual activities 01 four themes identified underpinned reasons ratings contributing treatment longevity preserving quality life escalating morbidity irrelevant futile information treatment patientscaregivers health professionals gave highest priority clinical outcomes contrast health professionals patientscaregivers gave higher priority lifestylerelated outcomes including impact familyfriends usual activities thus prioritization inform core outcome set improve consistency relevance outcomes trials pd shared decisionmaking clinical care options endstage kidney disease limited inconsistencies reporting outcomes omission patientimportant outcomes trials generated consensusbased prioritized list outcomes reported trials peritoneal dialysis pd international online threeround delphi survey patientscaregivers health professionals rated importance outcomes using 9point likert scale 79 indicating critical importance provided comments using bestworst scale bws relative importance outcomes estimated comments analyzed thematically total 873 participants 207 patientscaregivers 666 health professionals 68 countries completed round one 629 completed round two 530 completed round three top outcomes pdrelated infection membrane function peritoneal dialysis failure cardiovascular disease death catheter complications ability usual activities compared health professionals patientscaregivers gave higher priority six outcomes blood pressure mean difference 04 fatigue 03 membrane function 03 impact familyfriends 01 peritoneal thickening 01 usual activities 01 four themes identified underpinned reasons ratings contributing treatment longevity preserving quality life escalating morbidity irrelevant futile information treatment patientscaregivers health professionals gave highest priority clinical outcomes contrast health professionals patientscaregivers gave higher priority lifestylerelated outcomes including impact familyfriends usual activities thus prioritization inform core outcome set improve consistency relevance outcomes trials pd reaching consensus important outcomes peritoneal dialysis patientskidney internationalvol 96issue 3previewthe standardized outcomes nephrology song initiative designed improve research productivity building consensus stakeholders involved peritoneal dialysis pd put life participation top list along treatmentrelated infection cardiovascular complications patient technique survival lead improved reporting outcomes prioritization future research fulltext pdf