Leslie Cunningham-Sabo, Barbara Lohse, Jessica Clifford, Alixanna Burg, Claudio Nigg
Fuel for Fun Process Evaluation Reveals Strong Implementation and Approval with Varied Parent Engagement
Journal of nutrition education and behavior
relationship hormonal fluctuations reproductive system occurrence low back pain lbp widely observed however causal impact specific variables may indicative hormonal reproductive factors age menopause anm age menarche aam length menstrual cycle lmc age first birth afb age last live birth alb age first sexual intercourse afs low back pain remains unclear study employed bidirectional mendelian randomization mr using publicly available summary statistics genome wide association studies gwas finngen consortium investigate causal links hormonal reproductive factors lbp various mr methodologies including inversevariance weighted ivw mregger regression weighted median utilized sensitivity analysis conducted ensure robustness validity findings subsequently multivariate mendelian randomization mvmr employed assess direct causal impact reproductive hormone factors risk lbp implementing bonferroni correction conducting rigorous quality control results mr indicated noteworthy association decreased risk lbp aam or0784 95 ci 06890891 p353e04 afb or0558 95 ci 04360715 p897e06 alb or0396 95 ci 02260692 p0002 afs or0602 95 ci 05180700 p347e10 moreover reverse mr analysis observed significant causal effects lbp anm aam lmc afs mvmr analysis demonstrated continued significance causal effect afb lbp adjusting bmi study explored causal relationship anm aam lmc afb afs alb prevalence lbp found early menarche early age first birth early age last live birth early age first sexual intercourse may decrease risk lbp insights enhance understanding lbp risk factors offering valuable guidance screening prevention treatment strategies atrisk women