Tarciane Aline Prata, Arnaldo Santos Leite, Valéria Maria Augusto, Daniel Cruz Bretas, Bruno Horta Andrade, Jaqueline das Graças Ferreira Oliveira, Aline Priscila Batista, George Luiz Lins Machado-Coelho, Eliane Mancuzo, Carolina Coimbra Marinho
Lung function and quality of life one year after severe COVID-19 in Brazil
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
cox models timedependent coefficients covariates widely used survival analysis highdimensional settings sparse regularization techniques employed variable selection existing methods timedependent cox models lack flexibility enforcing specific sparsity patterns ie covariate structures propose flexible framework variable selection timedependent cox models accommodating complex selection rules method adapt arbitrary grouping structures including interaction selection temporal spatial tree directed acyclic graph structures achieves accurate estimation low false alarm rates develop sox package implementing network flow algorithm efficiently solving models complex covariate structures sox offers userfriendly interface specifying grouping structures delivers fast computation examples including case study identifying predictors time allcause death atrial fibrillation patients demonstrate practical application method specific selection rules