Ishfaq Rashid, Pramil Tiwari, Sanjay D'Cruz, Shivani Jaswal
Nutritional status, symptom burden, and predictive validity of the Pt-Global web tool/PG-SGA in CKD patients: A hospital based cross sectional study
PLOS global public health
omics methods widely used basic biology translational medicine research omics data collected explain impact certain risk factors clinical outcomes explain mechanism risk factors core question find genesproteinsmetabolites mediate effects clinical outcome mediation analysis modeling framework study relationship risk factors pathological outcomes via mediator variables however highdimensional omics data far challenging traditional data 1 tens thousands genes overcome curse dimensionality reliably select set mediators 2 ensure selected mediators functionally consistent 3 many biological mechanisms contain nonlinear effects include nonlinear effects highdimensional mediation analysis 4 consider multiple risk factors time meet challenges propose new exploratory mediation analysis framework mednet focuses finding mediators predictive modeling propose new definitions predictive exposure predictive mediator predictive network mediator using statistical hypothesis testing framework identify predictive exposures mediators additionally two heuristic search algorithms proposed identify network mediators essentially subnetworks genomescale biological network mediate effects single multiple exposures applied mednet breast cancer data set metabolomics data set combined food intake questionnaire data identified functionally consistent network mediators exposures impact outcome facilitating data interpretation