Janine Walker|Philip J. Batterham|Andrew Mackinnon|Anthony F. Jorm|Ian B. Hickie|Michael Fenech|Marjan Kljakovic|Dimity A. Crisp|Helen Christensen
Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms—the Beyond Ageing Project: a randomized controlled trial
Australian National University
evidence remains unclear whether folic acid fa vitamin b12 supplementation effective reducing depressive symptomsthe objective determine whether oral fa vitamin b12 supplementation prevented cognitive decline cohort communitydwelling older adults elevated psychological distressa randomized controlled trial rct completely crossed 2 2 2 factorial design comprising daily oral 400 g fa 100 g vitamin b12 supplementation compared placebo physical activity promotion depression literacy comparator control interventions reducing depressive symptoms conducted 900 adults aged 6074 elevated psychological distress kessler distress 10scale scores 15 2y intervention delivered 10 modules via mail concurrent telephone tracking calls main outcome measures examined change cognitive functioning 12 24 mo using telephone interview cognitive statusmodified ticsm brief test adult cognition telephone processing speed informant questionnaire cognitive decline elderly administered 24 mofa vitamin b12 improved ticsm total p 0032 effect size 017 ticsm immediate p 0046 015 ticsm delayed recall p 0013 effect size 018 scores 24 mo comparison placebo significant changes evident orientation attention semantic memory processing speed informant reportslongterm supplementation daily oral 400 g fa 100 g vitamin b12 promotes improvement cognitive functioning 24 mo particularly immediate delayed memory performance trial registered clinicaltrialsgov nct00214682