May A. Beydoun|Jose A Canas|Gregory A. Dore|Hind A. Beydoun|Ola S. Rostant|Marie Fanelli Kuczmarski|Michele K. Evans|Alan B. Zonderman
Serum Uric Acid and Its Association with Longitudinal Cognitive Change Among Urban Adults
National Institute on Aging|Nemours Children’s Clinic|National Institute on Aging|Eastern Virginia Medical School|National Institute on Aging|University of Delaware|National Institute on Aging|National Institute on Aging
uric acid waste metabolite among humans linked various cognitive outcomes describe sex agegroup specific associations baseline serum uric acid suabase significant change sua sua 1 versus 0 decrease versus change 2 versus 0 increase versus change longitudinal annual rate cognitive change among large sample urban adults data healthy aging neighborhoods diversity across life span study 20042009 visit 1 20092013 visit 2 used 3720 adults selected baseline age range 3064 complete data available n 14871602 mean repeat 1517 visitsparticipant cognitive test domains spanned attention processing speed learningmemory executive function visuospatialvisuoconstruction ability languageverbal global cognitive function sua measured visits multiple mixedeffects regression analyses conducted total population higher suabase associated faster annual rate decline measure visual memoryvisuoconstruction ability benton visual retention test 007 standard error 002 p 0001 among older men significant increase sua associated slower decline test attentionprocessing speed namely trailmaking test part measured seconds completion 691 173 p 0001 sum higher suabase associated faster cognitive decline overtime visual memoryvisuoconstruction ability test sua particular beneficial effects increasing sua domain attentionprocessing speed among older men longitudinal studies needed examine cognitive domainspecific effects overtime change sua within sex age groups