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covid19 pandemic forced people give daily routines adjust new circumstances might affected healthrelated quality life hrqol aimed compare hrqol first covid19 wave 2020 hrqol pandemic identify determinants hrqol pandemic switzerland conducted crosssectional online survey pandemic may july 2020 cowell sample convenience sample pandemic 20152016 conducted crosssectional paperbased survey among representative random sample swiss general population sgp sample samples assessed physical mental hrqol short form36 sociodemographic characteristics cowell sample additionally assessed health covid19related characteristics data analysed using linear regressions cowell sample included 1581 participants 76 women mean age 43 years sd 14 years sgp sample 1209 participants 58 women mean age 49 years sd 15 years adjusted sex age education cowell sample reported higher physical hrqol pcs 58 95 ci 51 66 p 0001 lower mental hrqol mcs 69 78 60 p 0001 sgp sample cowell sample especially persons lower health literacy support network covid19 reported lower hrqol aspects unique covid19 pandemic affected hrqol vulnerable persons covid19 less support opportunities lower health literacy especially prone impaired hrqol covid19 pandemic