Yazeed S Alahmed, Haytham S Alzeadi, Anfal K Alghumayzi, Leen A Almarshad, Abdulmajeed S Alharbi, Abdulelah S Alharbi
Knowledge and Attitudes of First Aid and Basic Life Support Among Public School Teachers in Qassim, Saudi Arabia
Cureus
develop disease stratification model covid19 updates according changes patients condition hospital facilitate patient management resource allocation retrospective cohort study adopted landmarking approach dynamic prediction allcause inhospital mortality next 48 hours accounted informative predictor missingness selected predictors using penalised regression data used study obtained single uk teaching hospital developed model using 473 consecutive patients covid19 presenting uk hospital 1 march 2020 12 september 2020 temporally validated using data 1119 patients presenting 13 september 2020 17 march 2021 primary outcome allcause inhospital mortality within 48 hours prediction time accounted competing risks discharge hospital alive transfer tertiary intensive care unit extracorporeal membrane oxygenation final model includes age clinical frailty scale score heart rate respiratory rate oxygen saturationfractional inspired oxygen ratio white cell count presence acidosis ph 735 interleukin6 internal validation achieved area receiver operating characteristic auroc 090 95 ci 087 093 temporal validation gave auroc 086 95 ci 083 088 model incorporates static risk factors eg age evolving clinical laboratory data provide dynamic risk prediction model adapts sudden gradual changes individual patients clinical condition successful external validation model potential powerful clinical risk assessment tool study registered researchregistry5464 research registry wwwresearchregistrycom