Alexander N Gorban, Bogdan Grechuk, Evgeny M Mirkes, Sergey V Stasenko, Ivan Y Tyukin
High-Dimensional Separability for One- and Few-Shot Learning
Entropy (Basel, Switzerland)
previous studies shown individuals similar mean glucose levels mg percentage time range tir may different hba1c values aim study elucidate mg tir associated hba1c data randomised clinical gold trial n144 followup silver trial n98 adults type 1 diabetes followed 25 years analysed total 596 paired hba1ccontinuous glucose monitoring measurements included linear mixedeffects models used account intraindividual correlations repeatedmeasures data gold trial mean age participants sd 4413 years 63 44 female mean hba1c sd 7298 mmolmol 8709 correlating mg hba1c mg explained 63 variation hba1c r079 p0001 variation hba1c explained mg increased 88 r094 p value improvement fit 0001 accounting persontoperson variation mghba1c relationship time range tbr 39 mmoll time range tar level 2 139 mmoll glycaemic variability little effect association given mg tir hba1c 10 individuals deviated 8 mmolmol 08 estimated hba1c based overall association mg tir hba1c tbr tar level 2 significantly influenced association tir hba1c given tir 1 increase tbr related 06 mmolmol lower hba1c 95 ci 04 09 p0001 2 increase tar level 2 related 04 mmolmol higher hba1c 95 ci 01 06 p0003 however neither tir tbr tar level 2 significantly associated hba1c accounting mg interindividual variations exist mg hba1c well tir hba1c clinically important deviations relatively large groups individuals type 1 diabetes results may provide important information healthcare providers individuals diabetes terms prognosis making diabetes management decisions