Edward Miller, Michael James Weightman, Ashna Basu, Andrew Amos
The importance of appraising articles and conducting psychiatric journal clubs
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
objective explore correlation periodontitis pd chronic kidney disease ckd adults well potential mechanisms involved methods data pd ckd national health nutrition examination survey nhanes database 1999 2014 downloaded weighted univariate multivariate logistic regression analyses conducted investigate risk factors associated pd ckd considering demographic clinical indicators using publicly available genomewide association study gwas summary datasets kidney disease periodontal disease outcome variables well 731 immune cell phenotypes 91 inflammatory proteins exposure factors open gwas database twosample mendelian randomization tsmr analysis performed using inversevariance weighted ivw method results seven demographic indicators including gender age race education level marital status income health related incidence ckd pd among elderly 60 years old poverty povertyincome ratio 13 divorce widowhood male ratio comorbidity group ckd pd 6712 8331 241 3683 4571 241 3441 4271 241 5778 7171 241 respectively significantly higher control group 2371 4 17917 623 2917 5 14117 623 1816 3 20017 623 4873 8 58717 623 respectively p0001 high educational level university selfrated excellent health accounted relatively small proportion comorbidity group 1410 1751 241 822 1021 241 respectively prevalence pd increased among individuals abnormal renal function indices including glomerular filtration rate urine proteincreatinine ratio serum creatinine serum uric acid blood urea nitrogen univariate logistic regression analysis showed positive correlation incidence pd ckd or214 95ci 190242 p0001 multivariate logistic regression analysis also indicated pd ckd potential risk factors pd ckd or122 95ci 107140 p0004 ckd pd or119 95ci 104137 p0012 furthermore adjusting model based demographic indicators still significant correlation pd ckd p001 mechanistically results tsmr analysis support existence common risk factor mediated immune cells ckd pd namely expression cd64 multiple innate immune cells mediates occurrence ckd pd absolute count cd64 monocytes associated increased risk ckd hr111 pd hr107 tendency showed absolute count cd64 neutrophils ckd hr122 pd hr123 conclusions positive correlation ckd pd particularly moderate severe pd shared pathogenesis involves cd64 monocytes circulatory system targeted interventions focusing cd64 molecules monocyte subsets may beneficial