Leonie DeClerk, Pam LaBorde, Laura Smith-Olinde
Debate as a learning tool in an online environment
Journal of the American Association of Nurse Practitioners
present study aimed investigate specific alterations brain networks patients poststroke depression psd assist elucidating brain mechanisms underlying psd would provide supporting evidence early diagnosis interventions disease restingstate functional magnetic resonace imaging data acquired 82 nondepressed stroke patients stroke 39 psd patients 74 healthy controls hc voxelwise degree centrality dc conjoined seedbased functional connectivity fc analyses performed investigate psdrelated connectivity alterations relationship alterations depression severity examined psd patients relative stroke hc groups 1 psd showed increased centrality regions within default mode network dmn including contralesional angular gyrus ang posterior cingulate cortex pcc hippocampus hip dc values contralesional ang positively correlated patient health questionnaire9 phq9 scores psd group 2 psd exhibited increased connectivity three seeds showing altered dc regions within dmn bilateral medial prefrontal cortex middle temporal gyrus ipsilesional superior parietal gyrus regions outside dmn bilateral calcarine ipsilesional inferior occipital gyrus contralesional lingual gyrus decreased connectivity contralesional ang contralesional supramarginal gyrus moreover fc alterations could predict phq9 scores psd group findings highlight psd related increased functional connectivity strength areas within dmn might attribute specific alterations connectivity within dmn outside dmn regions psd