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suboptimal mental health literacy levels among general hospital health care professionals negatively impact care coordination patients physicalmental comorbidity review examine evidence effectiveness interventions improve mental health literacy general hospital health care professionals systematic search literature conducted 13 electronic databases manual searching reference lists 1980 2021 studies screened preset eligibility criteria participants general hospital health care professionals taking care adult patients interventions aimed improving components participants mental health literacy comparisons alternative active intervention intervention primary outcomes aspects mental health literacy eight randomized controlled trials n 1732 participants included review evidence indicated mental health literacy interventions educational components improve components health care professionals mental health literacy terms mental health knowledge mental illnessrelated attitudesstigma addition studies evaluated components participants mental health literacy based available evidence educational interventions positive effect components general hospital health care professionals mental health literacy health care organizations provide educational programs enhance general hospital health care professionals mental health literacy studies needed explore interventions target components general hospital staffs mental health literacy evaluate impact psychiatric consultationliaison service utilization general hospitals well patient outcomes