Nicole Akar-Ghibril, Kimberly F Greco, Medina Jackson-Browne, Wanda Phipatanakul, Perdita Permaul
High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children
The Journal of allergy and clinical immunology
physicians often asked make prognostic assessments often worry assessments prove inaccurate prognostic systems developed enhance accuracy assessments paper describes approach evaluating prognostic systems based accuracy calibration discrimination generalizability reproducibility transportability systems predictions reproducibility ability produce accurate predictions among patients included development system population transportability ability produce accurate predictions among patients drawn different plausibly related population basis observation generalizability prognostic system commonly limited single historical period geographic location methodologic approach disease spectrum followup interval describe working hierarchy cumulative generalizability prognostic systems approach illustrated structured review dukes jass staging systems colon rectal cancer applied young man colon cancer treats development system black box evaluates performance predictions approach applied system generates predicted probabilities although dukes jass staging systems discrete approach also applied systems generate continuous predictions modification systems predict multiple time periods like scientific hypothesis generalizability prognostic system established tested found accurate across increasingly diverse settings numerous diverse settings system tested found accurate likely generalize untested setting