Su Gao|Yinlong Jin|Kathleen Hall|Chaoke Liang|Fred Unverzagt|Ru-Rong Ji|Jill R. Murrell|Jun Cao|Jianzhao Shen|Feng Ma|Janetta Matesan|Bo Ying|Ya?Yun Cheng|Jianchao Bian|Pu Li|Hugh C. Hendrie
Selenium Level and Cognitive Function in Rural Elderly Chinese
Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Indiana University – Purdue University Indianapolis|Chinese Center For Disease Control and Prevention|Chinese Center For Disease Control and Prevention|Sichuan Center for Disease Control and Prevention|Regenstrief Institute|Indiana University – Purdue University Indianapolis
selenium trace element associated antioxidant activity considered protective agent free radicals enhanced enzyme activity studies selenium cognitive function alzheimers disease yielded inconsistent results crosssectional survey 2000 rural chinese aged 65 years older two provinces peoples republic china conducted december 2003 may 2005 use community screening instrument dementia consortium establish registry alzheimers disease cerad word list learning test indiana university story recall test animal fluency test indiana university token test 70 study participants lived village since birth nail samples collected analyzed selenium contents analysisofcovariance models used estimate association quintile selenium levels measured nail samples cognitive test scores adjustment covariates lower selenium levels measured nail samples significantly associated lower cognitive scores p 00087 tests except animal fluency test p 04378 doseresponse effect selenium quintiles also seen significant associations results geographically stable cohort support hypothesis lifelong low selenium level associated lower cognitive function