Ingrid V. Bassett|Senica Chetty|Bingxia Wang|Matilda Mazibuko|Janet Giddy|Zhigang Lu|Rochelle P. Walensky|Kenneth A. Freedberg|Elena Losina
Loss to Follow-Up and Mortality Among HIV-Infected People Co-Infected With TB at ART Initiation in Durban, South Africa
Massachusetts General Hospital|McCord Hospital|Harvard University|Massachusetts General Hospital|McCord Hospital|McCord Hospital|Massachusetts General Hospital|Boston University|Harvard University|Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Boston University|Harvard University|Brigham and Women's Hospital|Massachusetts General Hospital
quantify impact tuberculosis tb coinfection death loss followup ltfu 12 months entry art programprospective intervention studyfrom may 2007 2008 patients undergoing preart training durban south africa screened pulmonary tb using mycobacterial culture subjects missing appointments 3 months phoned patients could reached considered ltfu deaths ascertained report family members used kaplanmeier method estimate time ltfu death 3 groups enrollment follows 1 newly diagnosed tb sputum culture 2 tb treatment ie previously diagnosed 3 tb free evaluated role tb mortality ltfu using cox proportional hazards modelsnine hundred fiftyone hivinfected subjects enrolled 59 female median baseline cd4 count 90 cells per microliter iqr 41148 cellsl one hundred fortyfour 15 newly diagnosed tb sputum culture additional 199 21 already tb treatment 12 months 26 newly diagnosed tb enrollment died ltfu compared 19 already tb treatment 14 tb free p 0001 controlling age sex smoking cd4 opportunistic infection history subjects newly diagnosed pulmonary tb 76 likely die ltfu hazard ratio 176 95 confidence interval 120 260 without tbhivtb coinfected individuals likely die ltfu within 12 months art clinic entry south africa patients require intensive followup art initiation