Jennifer Kim|Fengxiu Ouyang|Jacqueline A. Pongracic|Yuan Fang|Yuanyuan Zhang|Liang Xue|Xing Huang|Deanna Caruso|Xin Liu|Shanchun Zhang|Xiping Xu|Xiaobin Wang
Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults
Lurie Children's Hospital|Lurie Children's Hospital|Lurie Children's Hospital|Anhui Medical University|Lurie Children's Hospital|Anhui Medical University|Anhui Medical University|Lurie Children's Hospital|Lurie Children's Hospital|Lurie Children's Hospital|University of Illinois at Chicago|Lurie Children's Hospital
backgroundthe prevalence allergic diseases increasing worldwide reasons well understood previous studies suggest trend might associated lifestyle urbanizationobjectivewe sought describe patterns sensitization allergic disease unselected agricultural chinese populationmethodsthe data derived communitybased twin study anqing china skin prick tests performed foods aeroallergens atopy defined sensitization 1 allergens allergic disease ascertained means selfreport analysis stratified sex age children 1117 years adults 18 years included 1059 samesex twin pairsresultsof 2118 subjects 576 male n 1220 ages ranged 11 71 years 433 children n 918 atopy observed 472 n 999 participants common sensitizing foods shellfish 167 peanut 123 common sensitizing aeroallergens dust mite 306 cockroach 252 birth order zygosity effect sensitization rates multivariate logistic regression models revealed risk factors sensitization include age foods sex aeroallergens rates food allergy asthma estimated less 1conclusionsatopic sensitization common rural farming chinese population particularly shellfish peanut dust mite cockroach prevalence allergic disease contrast quite low prevalence allergic diseases increasing worldwide reasons well understood previous studies suggest trend might associated lifestyle urbanization sought describe patterns sensitization allergic disease unselected agricultural chinese population data derived communitybased twin study anqing china skin prick tests performed foods aeroallergens atopy defined sensitization 1 allergens allergic disease ascertained means selfreport analysis stratified sex age children 1117 years adults 18 years included 1059 samesex twin pairs 2118 subjects 576 male n 1220 ages ranged 11 71 years 433 children n 918 atopy observed 472 n 999 participants common sensitizing foods shellfish 167 peanut 123 common sensitizing aeroallergens dust mite 306 cockroach 252 birth order zygosity effect sensitization rates multivariate logistic regression models revealed risk factors sensitization include age foods sex aeroallergens rates food allergy asthma estimated less 1 atopic sensitization common rural farming chinese population particularly shellfish peanut dust mite cockroach prevalence allergic disease contrast quite low