Lorenzo Ciccione, Mathias Sablé-Meyer, Esther Boissin, Mathilde Josserand, Cassandra Potier-Watkins, Serge Caparos, Stanislas Dehaene
Trend judgment as a perceptual building block of graphicacy and mathematics, across age, education, and culture
Scientific reports
large proportion nursing home nh residents suffer dementia effects conventional antidementia drugs health poorly known aimed investigate associations exposure antidementia drugs mortality among nh residents retrospective longitudinal observational study involved 329 french nh residents admitted facilities since 2014 major neurocognitive disorder electronic health records obtained age sex level dependency charlson comorbidity index mini mental examination score admission exposure antidementia drugs determined using prescription 4 categories none exposure acetylcholinesterase inhibitors achei alone exposure memantine alone exposure achei memantine survival end 2019 studied entire cohort cox proportional hazards alleviate bias related prescription antidementia drugs formed propensityscore matched cohorts type antidementia drug exposure studied survival method studied 25358 nh residents major neurocognitive disorder age admission 871 71 years 698 women exposure antidementia drugs occurred 2550 101 achei alone 2055 81 memantine alone 460 02 achei plus memantine whereas 20293 800 exposure antidementia drugs adjusted hazard ratios mortality significantly reduced three groups exposed antidementia drugs compared reference group hr 0826 95ci 0769 0888 achei 0857 95ci 0795 0923 memantine 0742 95ci 0640 0861 achei plus memantine results consistent propensityscore matched cohorts use conventional antidementia drugs associated lower mortality nursing home residents dementia widely used population