Kailin L. Hsu|Jeffrey C. Fink|Jennifer S. Ginsberg|Marni Yoffe|Min Zhan|Wanda Fink|Corinne Woods|Clarissa J. Diamantidis
Self-reported Medication Adherence and Adverse Patient Safety Events in CKD
University of Maryland, Baltimore|University of Maryland, Baltimore|VA Maryland Health Care System|University of Maryland, Baltimore|University of Maryland, Baltimore|University of Maryland, Baltimore|University of Maryland, Baltimore|University of Maryland, Baltimore|Durham VA Medical Center|Duke University
h3backgroundh3 promoting medication adherence recognized challenge prescribers study examine whether lower medication adherence associated adverse safety events individuals decreased estimated glomerular filtration rates egfrs h3study designh3 crosssectional baseline analysis prospective cohort h3setting participantsh3 baseline analysis safe kidney care skc cohort study prospective study individuals egfrs60 mlmin173 msup2sup intended assess incidence diseasespecific safety events kidney transplant recipients excluded h3predictorh3 selfreported medication adherence based responses 3 questions ascertaining degree medication regimen adherence h3outcomesh3 adverse safety events selfreported baseline class events hypoglycemia fall thought related medication detected incidentally baseline visit class ii events example hypotension hyperkalemia potential drugrelated problems drps determined analyzing participants medications respect dosing guidelines based screening egfrs time medication reporting h3measurementsh3 relationship medication adherence diseasespecific patient safety events h3resultsh3 293 skc participants 154 53 classified lower medication adherence multivariable adjustment lower medication adherence significantly associated class ii safety event prevalence ratio pr 121 95 ci 104141 potential drps pr 129 95 ci 102163 lower medication adherence also significantly associated multiple 2 class events pr 171 95 ci 118249 multiple class ii events pr 135 95 ci 104176 multiple potential drps pr 211 95 ci 108269 compared higher medication adherence h3limitationsh3 use selfreported medication adherence rather pharmacy records clinical relevance detected safety events unclear h3conclusionsh3 lower medication adherence associated adverse safety events individuals egfrs60 mlmin173 msup2sup