Elyse R. Park|Giselle K. Perez|Susan Regan|Alona Muzikansky|Douglas E. Levy|Jennifer S. Temel|Nancy A. Rigotti|William F. Pirl|Kelly Irwin|Ann H. Partridge|Mary E. Cooley|Elisa Friedman|Julia Rabin|Colin Ponzani|Kelly A. Hyland|Susan Holland|Sarah Borderud|Kim Sprunck|Diana Kwon|Lisa A. Peterson|Jacob Miller-Sobel|Irina Gonzalez|C. Will Whitlock|Laura Malloy|Suhana de León-Sanchez|Maureen O’Brien|Jamie S. Ostroff
Effect of Sustained Smoking Cessation Counseling and Provision of Medication vs Shorter-term Counseling and Medication Advice on Smoking Abstinence in Patients Recently Diagnosed With Cancer
Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Harvard University|Massachusetts General Hospital|Massachusetts General Hospital|Massachusetts General Hospital|Harvard University|Harvard University|Massachusetts General Hospital|Massachusetts General Hospital|Harvard University|Harvard University|Dana-Farber Cancer Institute|Harvard University|Massachusetts General Hospital|Harvard University|Dana-Farber Cancer Institute|Harvard University|Dana-Farber Cancer Institute|Massachusetts General Hospital|Massachusetts General Hospital|Massachusetts General Hospital|Moffitt Cancer Center|Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering Cancer Center|Dana-Farber Cancer Institute|Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Memorial Sloan Kettering Cancer Center|Benson-Henry Institute|Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering Cancer Center
h3importanceh3 persistent smoking may cause adverse outcomes among patients cancer many cancer centers fully implemented evidencebased tobacco treatment routine care h3objectiveh3 determine effectiveness sustained telephone counseling medication intensive treatment compared shorterterm telephone counseling medication advice standard treatment assist patients recently diagnosed cancer quit smoking h3design setting participantsh3 unblinded randomized clinical trial conducted massachusetts general hospitaldanafarberharvard cancer center memorial sloan kettering cancer center adults smoked 1 cigarette within 30 days spoke english spanish recently diagnosed breast gastrointestinal genitourinary gynecological head neck lung lymphoma melanoma cancers eligible enrollment occurred november 2013 july 2017 assessments completed end february 2018 h3interventionsh3 participants randomized intensive treatment n 153 standard treatment n 150 received 4 weekly telephone counseling sessions medication advice intensive treatment group also received 4 biweekly 3 monthly telephone counseling sessions choice food drug administrationapproved cessation medication nicotine replacement therapy bupropion varenicline h3main outcome measuresh3 primary outcome biochemically confirmed 7day point prevalence tobacco abstinence 6month followup secondary outcomes treatment utilization rates h3resultsh3 among 303 patients randomized mean age 583 years 170 women 561 221 781 completed trial sixmonth biochemically confirmed quit rates 345 n 51 intensive treatment group vs 215 n 29 standard treatment group difference 130 95 ci 30233 odds ratio 192 95 ci 113327ipi lt 02 median number counseling sessions completed 8 interquartile range 411 intensive treatment group total 97 intensive treatment participants 770 vs 68 standard treatment participants 591 reported cessation medication use difference 179 95 ci 63295 odds ratio 231 95 ci 132404ipi 003 common adverse events intensive treatment standard treatment groups respectively nausea n 13 n 6 rash n 4 n 1 hiccups n 4 n 1 mouth irritation n 4 n 0 difficulty sleeping n 3 n 2 vivid dreams n 3 n 2 h3conclusions relevanceh3 among smokers recently diagnosed cancer 2 national cancer institutedesignated comprehensive cancer centers sustained counseling provision free cessation medication compared 4week counseling medication advice resulted higher 6month biochemically confirmed quit rates however generalizability study findings uncertain requires research h3trial registrationh3 clinicaltrialsgov identifiernct01871506