Riccardo E. Marioni|Allan F. McRae|Jan Bressler|Elena Colicino|Eilís Hannon|Shuo Li|Diddier Prada|Jennifer A. Smith|Letizia Trevisi|Pei-Chien Tsai|Dina Vojinovi?|Jeannette Simino|Daniel Levy|Chunyu Liu|Michael Mendelson|Claudia L. Satizabal|Qiong Yang|Min A. Jhun|Sharon L. R. Kardia|Wei Zhao|Stefania Bandinelli|Luigi Ferrucci|Dena G. Hernandez|Andrew Singleton|Sarah E. Harris|John M. Starr|Douglas P. Kiel|Robert R. McLean|Allan C. Just|Joel Schwartz|Avron Spiro|Pantel Vokonas|Najaf Amin|M. Arfan Ikram|André G. Uitterlinden|Joyce B. J. van Meurs|Tim D. Spector|Claire J. Steves|Andrea A. Baccarelli|Jordana T. Bell|Cornelia M. van Duijn|Myriam Fornage|Yi Hsiang Hsu|Jonathan Mill|Thomas H. Mosley|Sudha Seshadri|Ian J. Deary
Meta-analysis of epigenome-wide association studies of cognitive abilities
University of Edinburgh|University of Queensland|The University of Texas Health Science Center at Houston|Columbia University|University of Exeter|Boston University|Instituto Nacional de Cancerología|University of Michigan–Ann Arbor|Harvard University|King's College London|Erasmus MC|University of Mississippi Medical Center|Boston University|Boston University|University of Michigan–Ann Arbor|University of Michigan–Ann Arbor|University of Michigan–Ann Arbor|Azienda Sanitaria di Firenze|National Institute on Aging|National Institute on Aging|National Institutes of Health|National Institute on Aging|National Institutes of Health|University of Edinburgh|University of Edinburgh|Harvard University|Harvard University|Icahn School of Medicine at Mount Sinai|Harvard University|Boston Public Schools|Boston University|Boston Public Schools|Boston University|Erasmus MC|Erasmus MC|Erasmus MC|Erasmus MC|King's College London|King's College London|Columbia University|King's College London|Erasmus MC|The University of Texas Health Science Center at Houston|Harvard University|Icahn School of Medicine at Mount Sinai|University of Mississippi Medical Center|Jackson Memorial Hospital|Boston University|University of Edinburgh
cognitive functions important correlates health outcomes across lifecourse individual differences cognitive functions partly heritable epigenetic modifications dna methylation susceptible genetic environmental factors may provide insights individual differences cognitive functions epigenomewide metaanalyses bloodbased dna methylation levels 420000 cpg sites performed seven measures cognitive functioning using data 11 cohorts cpgs passed bonferroni correction adjusting number cpgs cognitive tests assessed longitudinal change genetic control methylation qtls associations brain health structural mri brain methylation alzheimers disease pathology across seven measures cognitive functioning metaanalysis n range 25576809 epigenomewide significant p 17 108 associations global cognitive function cg21450381 p 16 108 phonemic verbal fluency cg12507869 p 25 109 cpgs located intergenic region chromosome 12 inpp5a gene chromosome 10 respectively probes moderate correlations 04 brain methylation brodmann area 20 ventral temporal cortex neither probe showed evidence longitudinal change latelife associations white matter brain mri measures one cohort data methylation qtl analysis suggested rs113565688 cis methylation qtl cg12507869 p 5 105 4 1013 two lookup cohorts demonstrate link bloodbased dna methylation measures phonemic verbal fluency global cognitive ability research warranted understand mechanisms linking genomic regulatory changes cognitive function health disease