Ferenc Köteles
Vague sensations. About the background and consequences of discordance between actual and perceived physiological changes
Clinical psychology review
children born art higher risk developing type 1 diabetes dm1 children conceived without art risk dm1 similar children conceived without art clear differences risk according method fertility treatment art associated higher risk adverse perinatal outcomes risk depends method art developmental origins health disease theory proposes prenatal stress provoke changes endocrine processes impact health later life nordic registerbased cohort study carried including children born denmark birth years 19942014 finland 19902014 norway 19842015 study included 76 184 liveborn singletons born art 4 403 419 born without art median followup 83 137 years art nonart group respectively cohort initiated committee nordic assisted reproductive technology safety conartas established linking national registry data medical birth registries national patient registries available nordic countries performed multivariable logistic regression analyses birth year intervals 19841990 19911995 19962000 20012005 20062010 20112015 adjusting year birth within interval sex child parity maternal age maternal diabetes maternal smoking pregnancy potential confounders followup 259 34 children born art diagnosed dm1 case 22 209 50 born without art corresponding adjusted odds ratio 098 95 ci 086111 within different birth year intervals significant difference risk dm1 two groups found except youngest cohort children born 20112015 art associated higher risk dm1 found significant differences risk dm1 comparing children born ivf versus icsi fresh versus frozen embryo transfer cases group main limitation study relatively short followup time incidence rate dm1 peaks ages 1014 years hence longer followup would benefit analyses particular subgroup analyses overall findings reassuring especially considering concomitantly increasing number children born art increasing incidence dm1 globally nordic registry study supported nordic trial alliancenordforsk rigshospitalets research foundation funding sources role study design collection analysis interpretation data writing report decision submit article publication none authors conflicts interest declare regarding study isrctn11780826