Nneka Isamah|Warachal Faison|Martha E. Payne|James R. MacFall|David C. Steffens|John L. Beyer|K Ranga R. Krishnan|Warren D. Taylor
Variability in Frontotemporal Brain Structure: The Importance of Recruitment of African Americans in Neuroscience Research
Duke University Hospital|Duke Medical Center|Duke University|Medical University of South Carolina|Duke Medical Center|Duke Medical Center|Duke Medical Center|Duke Medical Center|Duke Medical Center|Duke-NUS Medical School|Duke Medical Center
variation brain structure genetically environmentally influenced question potential differences brain anatomy across populations differing race ethnicity remains controversial issue studies specifically examining racial ethnic differences also studies test racerelated differences context neuropsychiatric research possibly due underrepresentation ethnic minorities clinical research within context conducted secondary data analysis examining volumetric mri data healthy participants compared volumes amygdala hippocampus lateral ventricles caudate nucleus orbitofrontal cortex ofc total cerebral volume caucasian africanamerican participants discuss importance finding context neuroimaging methodology also need improved recruitment african americans clinical research broader implications better understanding neural basis neuropsychiatric disordersthis case control study setting academic medical center outpatient service participants consisted 44 caucasians 33 ethnic minorities following volumetric data obtained amygdala hippocampus lateral ventricles caudate nucleus orbitofrontal cortex ofc total cerebrum participant completed 15 magnetic resonance imaging mri primary finding analyses brain subregions compared caucasians african americans exhibited larger left ofc volumes f 168 750 p 0008the biological implications findings unclear know factors may contributing observed differences however study raises several questions important implications future neuropsychiatric research