Irene R. Dégano|Jaume Marrugat|María Grau|Betlem Salvador-González|Rafael Ramos|Alberto Zamora|Ruth Martí|Roberto Elosúa
The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index
Centro de Investigación en Red en Enfermedades Cardiovasculares|Instituto de Salud Carlos III|Hospital Del Mar|Hospital del Mar Research Institute|Municipal Institute for Medical Research|Centro de Investigación en Red en Enfermedades Cardiovasculares|Instituto de Salud Carlos III|Hospital Del Mar|Hospital del Mar Research Institute|Municipal Institute for Medical Research|Universitat de Barcelona|Hospital Del Mar|Hospital del Mar Research Institute|Municipal Institute for Medical Research|Hospital Del Mar|Hospital del Mar Research Institute|Municipal Institute for Medical Research|Institut Català de la Salut|Institut Universitari d'Investigació en Atenció Primària Jordi Gol|University of Girona|Clínica Girona|University of Girona|Institut Universitari d'Investigació en Atenció Primària Jordi Gol|Institut d'Investigació Biomèdica de Girona|Centro de Investigación en Red en Enfermedades Cardiovasculares|Instituto de Salud Carlos III|Hospital Del Mar|Hospital del Mar Research Institute|Municipal Institute for Medical Research
abstract education cardiovascular disease cvd inversely associated mediating factors totally elucidated aim analyze mediating role modifiable risk factors cohort study using regicor population cohorts participants without previous cvd included n 9226 marginal structural models used analyze association education cvd incidence 6 years followup mediation modifiable risk factors diabetes dyslipidemia hypertension smoking body mass index physical activity assessed using counterfactual framework participants university degree cvd incidence hazard ratio hr 051 95 confidence interval ci 030 085 compared primary lower education hypertension bmi diabetes mediated association education cvd incidence accounting 26 association 139 69 52 respectively sensitivity analyses showed hypertension strongest mediator average causal mediation effect 95 ci increase 2170 days free cvd events 711 4520 association education cvd incidence partially mediated hypertension bmi diabetes interventions decrease prevalence risk factors could contribute diminish cvd inequalities associated educational level