Edwin P Armitage, Gabrielle de Crombrugghe, Alexander J Keeley, Elina Senghore, Fatoumata E Camara, Musukoi Jammeh, Amat Bittaye, Haddy Ceesay, Isatou Ceesay, Bunja Samateh, Muhammed Manneh, Beate Kampmann, Claire E Turner, Adam Kucharski, Anne Botteaux, Pierre R Smeesters, Thushan I de Silva, Michael Marks
Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
The Lancet. Microbe
studies examined neurodevelopmental consequences prenatal exposure opioid analgesics therefore necessary gain knowledge inform clinical decisions pregnant women moderate severe pain investigate fifthgrade scholastic skills children prenatal exposure opioid analgesics cohort study conducted based data norwegian mother father child cohort 19992008 data linked medical birth registry norway data statistics norway included 64 256 liveborn singletons born 54 568 mothers reported pain pregnancy analyzed study conducted july 1 december 15 2021 selfreported exposure opioid analgesics pregnancy characterized terms exposure exposure timing exposure duration scores 3 national tests children fifth grade tests measured scholastic skills literacy numeracy english language test scores standardized z scores differences z scores compared children mothers exposed opioid analgesics pregnancy children mothers prepregnancy opioid exposure 64 256 children included 32 521 boys 506 1483 children 23 exposed opioid analgesic least gestation test scores similar children exposure opioid analgesics utero children prepregnancy exposure children exposed first trimester exposed two three 4week intervals pregnancy scored lower children mothers prepregnancy exposures tests literacy weighted w 013 95 ci 025 001 w 019 95 ci 035 004 numeracy w 014 95 ci 025 004 w 019 95 ci 034 005 differences small may clinically relevant large birth cohort prenatal exposure opioid analgesics substantial negative association fifthgrade scholastic skills however adequate pain management pregnancy may addressed individual patient level bearing mind benefits risks different analgesic therapies