Manami Ochi, Aya Isumi, Tsuguhiko Kato, Satomi Doi, Takeo Fujiwara
Adachi Child Health Impact of Living Difficulty (A-CHILD) Study: Research Protocol and Profiles of Participants
Journal of epidemiology
evaluate utility dilute prothrombin time dpt diagnosing antiphospholipid syndrome aps alone paired dilute russell viper venom time drvvt dilute prothrombin time drvvt testing performed plasma samples spiked apixaban rivaroxaban depleted vitamin kdependent clotting factors retrospective analysis functional aps testing results 44month period university chicago medical center performed spiking studies screening clotting time dpt dpts sensitive deficiency vitamin kdependent factors screening clotting time drvvt drvvts converse true factor xa direct oral anticoagulant doacspiked plasma 44month retrospective analysis 26 clinical aps panels showed isolated positivity dptbased system comparing dptbased system drvvtbased system showed utility identifying falsepositive drvvt results due anticoagulation drvvtsdpts ratio 0785 lower predicted international normalized ratio 15 higher sensitivity 863 specificity 604 likelihood ratio 218 conversely drvvtsdpts ratio 1165 higher optimal cutoff predicting identification factor xa doac sensitivity 618 specificity 778 likelihood ratio 278 within data set full drvvt dpt results parameters identified could improve identification samples anticoagulation interference dilute prothrombin time lupus anticoagulant assay rarely sole laboratory functional evidence aps combined drvvt dpt serve effective screen common anticoagulant interference