Sun Youn Lee, Shusaku Sasaki, Hirofumi Kurokawa, Fumio Ohtake
The school education, ritual customs, and reciprocity associated with self-regulating hand hygiene practices during COVID-19 in Japan
BMC public health
safety efficacy extended halflife factor viii fviii product damoctocog alfa pegol bay 949027 jivi demonstrated protect viii kids study nct01775618 male previouslytreated patients ptps aged 12 years old severe haemophilia 50 exposure days eds treated prophylactically protect viii kids extension study assessed longterm safety efficacy damoctocog alfa pegol population evaluate longterm impact damoctocog alfa pegol post hoc subgroup analysis adolescent patients protect viii kids study extension 12th birthday onwards current analysis included ptps aged 12 years old remained extension 6 months following 12th birthday observation period defined time 12th birthday end extension period data birthday included whether main study extension phase main efficacy variable annualised bleeding rate abr main safety variable frequency inhibitor development subgroup analysis comprised 25 patients median observation time 12th birthday 32 years median totaljointspontaneous abrs observation period 170703 respectively safety findings consistent reported overall study population confirmed fviii inhibitors antidrug antibodies reported damoctocog alfa pegol efficacious favourable safety profile adolescents haemophilia supporting longterm use children adolescents