Matthew J. Kirby|David Ameh|Christian Bottomley|Clare Green|Musa Jawara|Paul Milligan|Paul Snell|David J. Conway|Steve W. Lindsay
Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial
Durham University|MRC Unit the Gambia|London School of Hygiene & Tropical Medicine|Durham University|MRC Unit the Gambia|MRC Unit the Gambia|London School of Hygiene & Tropical Medicine|MRC Unit the Gambia|University of Bristol|MRC Unit the Gambia|London School of Hygiene & Tropical Medicine|Durham University
house screening protect people malaria assessed whether two types house screeningfull screening windows doors closing eaves installation screened ceilingscould reduce house entry malaria vectors frequency anaemia children area seasonal malaria transmissionduring 2006 2007 500 occupied houses near farafenni town gambia area low use insecticidetreated bednets randomly assigned receive full screening screened ceilings screening control randomisation done computergenerated list permuted blocks five houses ratio 221 screening treated insecticide exposure mosquitoes indoors assessed fortnightly light trap collections transmission season primary endpoints included number female anopheles gambiae sensu lato mosquitoes collected per trap per night secondary endpoints included frequency anaemia haemoglobin concentration 80 gl parasitaemia end transmission season children aged 6 months 10 years living study houses analysis modified intention treat itt including randomised houses outcome data children houses sampled haemoglobin parasitaemia study registered international standard randomised controlled trial number isrctn51184253462 houses included modified itt analysis full screening n188 screened ceilings n178 control n96 mean number gambiae caught houses without screening 375 per trap per night 95 ci 316433 compared 152 129174 houses full screening ratio means 041 95 ci 031054 p00001 191 161221 houses screened ceilings ratio 053 040070 p00001 755 children completed study 731 complete clinical covariate data used analysis clinical outcomes 30 19 158 children control houses anaemia compared 38 12 309 houses full screening adjusted odds ratio 053 95 ci 029097 p004 31 12 264 houses screened ceilings 051 027096 p004 frequency parasitaemia differ intervention control groupshouse screening substantially reduced number mosquitoes inside houses could contribute prevention anaemia childrenmedical research council