Man Jit Jess Kwok, Wright Jacob
Framework for implementing asylum seekers and refugees' health into the undergraduate medical curriculum in the United Kingdom
Health education research
hypertrophic cardiomyopathy hcm widespread hereditary cardiac pathology characterized thickened heart walls rearrangement cardiomyocytes despite extensive research mechanisms underlying hcm development remain poorly understood impeding development effective therapeutic diagnostic strategies recent studies suggested polygenic nature hcm development alongside monogenic forms transcriptomic profiling valuable tool investigating diseases study propose novel approach study regulatory micrornas mirnas context hcm utilizing stateoftheart data analysis tools method involves applying monte carlo simulation machine learning algorithm transcriptomic data generate highcapacity classifiers hcm classifiers extract key genes crucial performance leading identification 16 key genes subsequently narrow pool mirnas selecting may target significant number key genes within best models particularly focused mir1243p validated association hcm independent dataset subsequent investigation function revealed involvement mir1243p rhoa signaling pathway present study combines generalization power machine learning biological expertise expanding traditional methods identifying mirna participants hcm pathogenesis paving way precision medicine cardiac care