Izzati Yussof, Noraida Mohamed Shah, Nur Fa'izah Ab Muin, Sarahfarina Abd Rahim, Ernieda Hatah, Nor Asyikin Mohd Tahir, Kavinash Loganathan, Murallitharan Munisamy
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aphasia among debilitating symptoms affecting stroke survivors speech language therapy slt effective many hours practice required make clinically meaningful gains one solution dosage problem automate therapeutic approaches via selfsupporting apps people aphasia pwa amass practice suits however response therapy variable clinical trial yet identified key brain regions required engage wordretrieval therapy sep 7 2020 mar 1 2022 university college london uk carried phase ii itemrandomised clinical trial 27 pwa using novel selfled app italkbetter utilises confrontation naming therapy unlike previously reported apps realtime utterance verification system drives adaptive therapy algorithm therapy items individually randomised provide balanced lists trained untrained items matched key psycholinguistic variables baseline performance pwa practised italkbetter 6week therapy block structural functional mri data collected identify therapyrelated changes brain states repeatedmeasures design employed trial registered clinicaltrialsgov nct04566081 italkbetter significantly improved naming ability 13 trained items compared change untrained items average increase 29 words sd 26 per person beneficial effects persisted three months pwas propositional speech also significantly improved italkbetter use associated brain volume increases right auditory left anterior prefrontal cortices taskbased fmri identified doserelated activity right temporoparietal junction findings suggested italkbetter significantly improves pwas naming ability trained items effect size similar previous rct computerised therapy first study show transfer naturalistic speaking task italkbetter usage dose caused observable changes brain structure function key parts surviving language perception production control networks italkbetter rolledout app pwa anomia httpswwwuclacukicnresearchresearchgroupsneurotherapeuticsprojectsdigitalinterventionsneurorehabilitation0 increase dosage practicebased slt national institute health care research wellcome centre human neuroimaging