Giuseppina Gini
QSAR: What Else?
Methods in molecular biology (Clifton, N.J.)
introduction bone marrow involved various haematological nonhaematological conditions paediatric age group understand analyse underlying etiology bone marrow examination including bone marrow aspiration trephine biopsy forms important diagnostic tool helps differentiate proliferative disorders myeloid lymphoid series find prognosis based severity assess status therapy started also aids staging detection infiltration marrow foreign cells spectrum disorders affecting marrow children ranges common disorders like nutritional deficiency anaemia serious conditions like leukaemia line management severity prognosis differ bone marrow lesions found adults present study done demonstrate utility bone marrow examination paediatric age group demonstrate contribution final diagnosis patient list study various lesions encountered age group tertiary care teaching hospital better understanding clinicopathological features microscopy suggesting variation convergence literature material methods observational study combination retrospective prospective studies carried period six years january 2014 december 2019 bone marrow aspiration biopsy samples received surgical pathology department tertiary healthcare centre study period patients zero 18 years age included samples obtained autopsy samples tissue diluted marrow inadequate excluded study detailed histomorphology studied cases data obtained recorded excel sheet descriptive statistics expressed terms numbers percentages study ethically approved ethics research committee hospital commencement study results maximum number marrows performed age group 1218 years followed six 12 years common indication performing bone marrow examination evaluation cytopenias followed suspectedto rule haematological malignancy male predominance found overall amongst neoplastic lesions acute leukaemia commonest diagnosis bone marrow infections second common lesion overall commonest nonneoplastic lesion encountered conclusion spectrum lesions requiring bone marrow examination paediatric age group varied etiologies bone marrow examination children useful understanding pathogenesis establishing tissue diagnosis ruling haematological malignancies causes cytopenias planning lines investigations management knowing response therapy prognosis