Wenrui Zhang, Yanbin Li, Longfeng Li, Stephen Hinshaw, Xiuyun Lin
Vicious cycle of emotion regulation and ODD symptoms among Chinese school-age children with ODD: a random intercept cross-lagged panel model
Child and adolescent psychiatry and mental health
purpose examine correlation antiseizure medication drug dose estimated prescription fill records prescription registers blood levels pregnancy conducted nationwide study mothers gave birth denmark 1 january 2014 31 december 2018 using data danish prescription laboratory registers identified mothers blood level measurements antiseizure medication main exposure estimated antiseizure medication dosage estimated pregnancyfilled prescriptions danish prescription register main outcome correlation estimated dose mean blood level antiseizure medication pregnancy privacy reasons number blood level measurement prescription fills rounded nearest 10 proportions reported exact values among 298 560 pregnancies identified pregnancies recorded prescription fill prescription register valproate n 90 lamotrigine n 1360 levetiracetam n 340 topiramate n 100 carbamazepine n 60 pregnancies blood level measurements available 50 53 pregnancies valproate 850 62 pregnancies lamotrigine 320 93 pregnancies levetiracetam 50 68 pregnancies carbamazepine 40 35 pregnancies topiramate pearsonss correlation coefficients correlation estimated antiseizure medication dose mean blood levels 067 p 00001 valproate 063 p 00001 lamotrigine 063 p 00001 levetiracetam 076 00001 carbamazepine 089 00001 topiramate dose antiseizure medication estimated prescription fills good proxy blood levels thus biological exposure pregnancy suggesting administrative prescription fill records may valuable resource estimating exposure antiseizure medication pregnancy