Jamshid Mehrzad, Mahdieh Dayyani, Mohammadreza Erfanian-Khorasani
The independent and combined effects of selected risk factors and Arg399Gln XRCC1 polymorphism in the risk of colorectal cancer among an Iranian population
Medical journal of the Islamic Republic of Iran
abstract therapeutic drug monitoring tdm quantification interpretation drug concentrations blood optimize pharmacotherapy considers interindividual variability pharmacokinetics thus enables personalized pharmacotherapy psychiatry neurology patient populations may particularly benefit tdm children adolescents pregnant women elderly patients individuals intellectual disabilities patients substance abuse disorders forensic psychiatric patients patients known suspected pharmacokinetic abnormalities nonresponse therapeutic doses uncertain drug adherence suboptimal tolerability pharmacokinetic drugdrug interactions typical indications tdm however potential benefits tdm optimize pharmacotherapy obtained method adequately integrated clinical treatment process supply treating physicians laboratories valid information tdm tdm task force arbeitsgemeinschaft fr neuropsychopharmakologie und pharmakopsychiatrie agnp issued first guidelines tdm psychiatry 2004 update 2011 time next update following new guidelines holds potential improve neuropsychopharmacotherapy accelerate recovery many patients reduce health care costs