Tessa Watts, Dominic Roche, Judit Csontos
Patients' experiences of cancer immunotherapy with immune checkpoint inhibitors: A systematic review and thematic synthesis
Journal of clinical nursing
modulating stress response perioperative factors paramount impact neurodevelopmental outcome infants undergo cardiac surgery utilizing cardiopulmonary bypass single center prospective followup study evaluated impact three different anesthetic techniques neurodevelopmental outcomes 19 children previously underwent congenital cardiac surgery within 1st year life cases done may 2011 december 2013 children assessed using stanfordbinet intelligence scales 5th edition multiple regression analysis used test different parental perioperative factors could significantly predict different neurodevelopmental outcomes entire cohort patients comparing three groups regarding major cognitive scores highdose fentanyl hdf patients scored significantly higher lowdose fentanyl ldf dexmedetomidine dex ldf dex group quantitative reasoning scores 106 22 vs 82 15 p 0046 bispectral index bis value end surgery ldf group significantly higher ldf dex group p 0011 entire cohort strong correlation seen standard verbal intelligence quotient iq score baseline adrenocorticotropic hormone level interleukin6 level end surgery bis value end procedure r2 value 067 p 004 inverse correlation cardiac intensive care unit length stay fullscale iq score r 04675 p 0027 patients hdf group demonstrated overall higher neurodevelopmental scores although reach statistical significance except fluid reasoning scores results may point possible correlation blunting stress response improvement neurodevelopmental outcome