Elisabeth W Segers, Marjolijn Ketelaar, Marjorie A C P de Man, Lisette Schoonhoven, Elise M van de Putte, Agnes van den Hoogen
How to support children to develop and express their coping preferences around minor invasive medical procedures: children's and parents' perspectives
European journal of pediatrics
universally accepted method evaluating lymph node metastasis lnm nonsmall cell lung cancer nsclc neoadjuvant chemoimmunotherapy different protocols recommend evaluating percentage residual viable tumor rvt metastatic tumor size mts aim determine prognostic significance rvt mts identify effective parameter pathological evaluating lnm two independent cohorts collected derivation n84 external validation n42 patients exhibited metastatic cancer treatment response lymph nodes postsurgery derivation cohort assessed mean largest values mts rvt lnm estimating optimal cutoffs eventfree survival efs using maximally selected rank statistics validation subsequently conducted external validation cohort quality prognostic factors evaluated using area curve auc positive association identified rvt mts absolute association could conclusively established derivation cohort neither largest mts cutoff6mm p028 largest rvt cutoff75 p023 mean rvt cutoff55 p006 associated efs however mean mts cutoff45mm lymph nodes statistically associated efs p0018 validated external cohort p0017 prognostic value mts exceeded ypn staging cohorts evidenced higher auc values mean value mts effectively serve parameter pathological evaluation lymph nodes threshold 45mm closely linked efs prognostic value outperforms ypn staging