Pooja Rai, Jonas S Sundarakumar, Nimisha Basavaraju, Reddy Peera Kommaddi, Thomas Gregor Issac
Association between ApoE ε4 genotype and attentional function in non-demented, middle-aged, and older adults from rural India
Journal of neurosciences in rural practice
subjective cognitive decline scd recognized preclinical indicator alzheimers disease ad stage provides valuable time window ultraearly intervention ad aim study investigate neurocognitive characteristics scd correlation objective cognition negative emotion sleep quality chinese elderly total 1200 volunteers aged 60 older underwent brief elderly cognitive screening inventory quick cognitive screening scale elderly generalized anxiety disorder7 patient health questionnaire9 pittsburgh sleep quality index core neuropsychological test according examination results participants divided healthy control hc scd groups neurocognitive function scd relationship objective cognition negative emotion sleep quality analyzed compared hc group scd group similar global cognitive function slightly impaired neurocognitive function adjusting confounding factors age sex marriage education chronic disease neurocognitive function picturesymbol matching or0167 95 ci 01050266 word stem completion 0260 95 ci 01310514 trail making test or0315 95 ci 01780560 picture recall 0278 95 ci 01220636 negative emotion subdepressive symptoms or2287 95 ci 14833527 subanxiety symptoms or1663 95 ci 10792563 poor sleep quality or2138 95 ci 15712909 significantly correlated occurrence scd study illustrates scd closely related objective cognition negative emotion sleep quality clinical evaluation followup scd fully account factors