Sarah E Hooper, Kent G Hecker, Elpida Artemiou
Using Machine Learning in Veterinary Medical Education: An Introduction for Veterinary Medicine Educators
Veterinary sciences
changes synaptic efficacy essential neuronal development learning memory formation pathological states neuronal excitability including temporallobe epilepsy synapses high probability opening postsynaptic receptors occupied released transmitter effective means augmenting postsynaptic responses increase number receptors combine quantal analysis evoked inhibitory postsynaptic currents quantitative immunogold localization synaptic gabaa receptors hippocampal granule cells order clarify basis inhibitory synaptic plasticity induced experimental model temporallobe epilepsy process known kindling find larger amplitude 66 increase elementary synaptic currents quantal size kindling results directly 75 increase number gabaa receptors inhibitory synapses somata axon initial segments receptor density 3440 synaptic junctional area expanded 31 presynaptic boutons enlarged may account 39 decrease average number released transmitter packets quantal content findings establish postsynaptic insertion new gabaa receptors corresponding increase postsynaptic responses augmenting efficacy mammalian inhibitory synapses