Melinda Butsch Kovacic|Jocelyn M. Biagini Myers|Mark Lindsey|Tia L. Patterson|Sharon Sauter|Mark B. Ericksen|Patrick Ryan|Amal Assa’ad|Michelle B. Lierl|Thomas J. Fischer|Carolyn M. Kercsmar|Karen M. McDowell|Anne W. Lucky|Anita P. Sheth|Andrew D. Hershey|Richard M. Ruddy|Marc E. Rothenberg|Gurjit K. Khurana Hershey
The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research
Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|University of Cincinnati|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center|Cincinnati Children's Hospital Medical Center
background allergic disorders including asthma allergic rhinitis atopic dermatitis eosinophilic esophagitis food allergy major global health burden study management allergic disorders complicated considerable heterogeneity presentation natural history disorders biorepositories serve excellent source data biospecimens delineating subphenotypes allergic disorders resources lacking methods order define subphenotypes allergic disease accurately established infrastructure link efficiently utilize clinical epidemiologic data biospecimens single biorepository called greater cincinnati pediatric clinic repository gcpcr children allergic disorders well healthy controls followed longitudinally hospital clinic emergency department inpatient visits subjects asthma allergy skin symptoms past medical family social diet environmental histories physical activity medication adherence perceived quality life demographics ascertained dna collected participants biospecimens blood hair nasal epithelial cells collected subset results date gcpcr 6317 predominantly caucasian african american participants 93 banked dna large sample size supports adequately powered genetic epidemiologic environmental health disparities studies childhood allergic diseases conclusions gcpcr unique biorepository continuously evaluated refined achieve maintain rigorous clinical phenotype biological data development similar diseasespecific repositories using common data elements necessary enable studies across multiple populations comprehensively phenotyped patients