Noelle Pavlovic, Chiadi E Ndumele, Martha Abshire Saylor, Sarah L Szanton, Christopher S Lee, Amil M Shah, Patricia P Chang, Roberta Florido, Kunihiro Matsushita, Cheryl Himmelfarb, Jeannie Marie Leoutsakos
Identification of Fatigue Subtypes and Their Correlates in Prevalent Heart Failure: A Secondary Analysis of the Atherosclerosis Risk in Communities Study
Circulation. Cardiovascular quality and outcomes
brain regionspecific changes demonstrated variety cognitive training interventions effect cognitive training brain subnetworks humans however remains largely unknown studies limited functional networks used wellestablished working memory training program stateofthe art neuroimaging methods 40 healthy adults 21 females mean age 265 years near fartransfer training effects assessed using computerized working memory executive function tasks adaptive working memory training led improvement nontrained working memory tasks generalization tasks reasoning inhibition graph theoretical analysis structural white matter network connectivity connectome revealed increased global integration within frontoparietal attention network following adaptive working memory training compared nonadaptive group furthermore impact outcome graph theoretical analyses different white matter metrics infer connection strength evaluated increased efficiency frontoparietal network best captured using connection strengths derived mr metrics thought sensitive differences myelination putatively indexed quantitative longitudinal relaxation rate r1 previously used diffusion mri metrics fractional anisotropy fibertracking recovered streamlines findings emphasize critical role specific microstructural markers providing important hints toward mechanisms underpinning traininginduced plasticity may drive working memory improvement clinical populations first study explore traininginduced changes structural connectome using wellcontrolled design examine cognitive training uptodate neuroimaging methods found changes global integration based white matter connectivity within frontoparietal attention network following adaptive working memory training compared nonadaptive comparison group furthermore impact different diffusion mr metrics specific markers white matter graph theoretical findings evaluated increase network global efficiency following working memory training best captured connection strengths weighted mr relaxation rates influenced myelination results important optimization cognitive training programs healthy individuals people brain disease