Anne C C Lee|Naoko Kozuki|Hannah Blencowe|Theo Vos|Adil N. Bahalim|Gary L. Darmstadt|Susan Niermeyer|Matthew Ellis|Nicola J. Robertson|Simon Cousens|Joy E Lawn
Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990
Brigham and Women's Hospital|Johns Hopkins University|London School of Hygiene & Tropical Medicine|Institute for Health Metrics and Evaluation|University of Washington|Global Fund to Fight AIDS, Tuberculosis and Malaria|Bill & Melinda Gates Foundation|Colorado School of Public Health|Center for Global Health|University of Bristol|London Women's Clinic|University College London|London School of Hygiene & Tropical Medicine|London School of Hygiene & Tropical Medicine
intrapartum hypoxic events birth asphyxia may result stillbirth neonatal postneonatal mortality impairment systematic morbidity estimates burden impairment outcomes currently limited neonatal encephalopathy ne following intrapartum hypoxic event strong predictor longterm impairmentlinear regression modeling conducted data identified systematic reviews estimate ne incidence time trends 184 countries metaanalyses undertaken estimate risk ne sex newborn neonatal case fatality rate impairment risk compartmental model estimated postneonatal survivors ne depending access care proportion survivors impairment separate modeling global burden disease 2010 gbd2010 study estimated disability adjusted life years dalys years life disability ylds years life lost ylls attributed intrapartumrelated eventsin 2010 115 million babies uncertainty range 089160 million 85 cases per 1000 live births estimated developed ne associated intrapartum events 96 born low middleincome countries compared 160 million 1990 117 cases per 1000 live births estimated 287000 181000440000 neonates ne died 2010 233000 163000342000 survived moderate severe neurodevelopmental impairment 181000 82000319000 mild impairment gbd2010 intrapartumrelated conditions comprised 502 million dalys 24 total 61 million yldsintrapartumrelated conditions large global burden mostly due high mortality lowincome countries universal coverage obstetric care neonatal resuscitation would prevent deaths disabilities rates impairment highest middleincome countries neonatal intensive care recently introduced quality may poor settings without neonatal intensive care impairment rate low due high mortality relevant scaleup basic neonatal resuscitation