Noora Hirvonen, Heidi Enwald, Anne-Kathrin Mayer, Raija Korpelainen, Riitta Pyky, Tuire Salonurmi, Markku J Savolainen, Cathrine Nengomasha, Ruth Abankwah, Wilhelm Uutoni, Raimo Niemelä, Maija-Leena Huotari
Screening everyday health information literacy among four populations
Health information and libraries journal
abundant evidence shown protective effect aerobic exercise central neuronal system however research resistance exercise remains limited evaluate effect potential molecular mechanisms resistance exercise improving cognition mental health threemonthold male c57bl6j mice underwent resistance training five weeks body parameters cognitive performance synaptic plasticity assessed groups total rna frontal cortex hippocampus gastrocnemius isolated sequenced go term kegg analysis performed identify molecular mechanisms results rna sequencing verified rtpcr data found mice training group showed reduced anxietylike behavior better spatial memory accordingly resistance exercise specifically increased number thin spines without affecting number kind spines mrna sequence analysis showed resistance exercise induced differential expression hundreds genes three tissues kegg analysis indicated foxo signaling pathway significant changed pathway throughout brain muscle go terms analysis showed sgk1 enriched three key cognition related bp including longterm memory learning memory memory expression level sgk1 positive related cognitive performance water maze conclusion resistance exercise improved mental health cognition synaptic plasticity mice integrating analysis mrna expression profiles frontal cortex hippocampus muscle reveals sgk1 key mediator brainmuscle crosstalk