Edosa Tesfaye Geta, Kifile Abdisa Lushe, Adisu Ewunetu Desisa, Dufera Rikitu Terefa, Melese Chego Cheme, Adisu Tafari Shama, Matiyos Lema
Determinants of community-based health insurance membership renewal decision among rural households in Kellem Wollega zone, Oromia regional state, Ethiopia: a community-based cross-sectional study
Frontiers in public health
surgical left atrial appendage laa closure concomitant openheart surgery prevents thromboembolism highrisk patients nevertheless highlevel evidence exist laa closure performed patients cha2ds2vasc score preoperative atrial fibrillation flutter af statusthe current trial attempts provide evidence study designed randomized openlabel blinded outcome assessor multicenter trial adult patients undergoing firsttime elective openheart surgery patients without af cha2ds2vasc score enrolled primary exclusion criteria planned laa closure planned af ablation ongoing endocarditis randomization threestep stratification process sort patients site surgery type preoperative expected oral anticoagulation treatment patients undergo balanced randomization 11 laa closure top planned cardiac surgery standard care block sizes vary 8 16 neurologists blinded randomization adjudicate primary outcome stroke including transient ischemic attack tia secondary outcomes include composite outcome stroke including tia silent cerebral infarcts outcome ischemic stroke including tia composite outcome stroke allcause mortality laa closure expected provide 60 relative risk reduction total 1500 patients randomized followed 2 years trial expected help form future guidelines within surgical laa closure statistical analysis plan ensures transparency analyses limits potential reporting biases clinicaltrialsgov nct03724318 registered 26 october 2018 httpsclinicaltrialsgovstudynct03724318 httpsdoiorg101016jahj202306003