Kamlesh Khunti|Srikanth Bellary|Muhammad Ali Karamat|Keyur Patel|Vinod Patel|Angus G. Jones|Jeremy Gray|Peter R. Shepherd|Wasim Hanif
Representation of people of South Asian origin in cardiovascular outcome trials of glucose?lowering therapies in Type 2 diabetes
University of Leicester|Aston University|Heart of England NHS Foundation Trust|Heart of England NHS Foundation Trust|University of Warwick|NIHR Surgical Reconstruction and Microbiology Research Centre
aim investigate proportional representation people south asian origin cardiovascular outcome trials glucoselowering drugs strategies type 2 diabetes noting among significant pieces evidence used formulate guidelines clinical practice largely basedwe searched cardiovascular outcome trials type 2 diabetes published january 2015 extracted data ethnicity participants compared expected values proportional representation south asian individuals based population data usa uk globallytwelve studies met inclusion criteria eight presented sufficiently detailed breakdown participant ethnicity permit numerical analysis general people south asian origin found underrepresented trials compared uk global expectations overrepresented compared us expectations among eight trials south asian representation could reliably estimated seven underrepresented group relative 112 uk diabetes population estimated south asian representation trials ranging 00 100clinicians exercise caution generalizing results trials practice regard ethnicity individuals efforts made improve reporting ethnicity improve diversity trial recruitment although acknowledge challenges must overcome make reality