Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Gustavo Reyes, Miriam R Simon, Emma M Pearce, Hanna Kim, Peter J Shaw, Courtney M Rowan, Jeffrey J Auletta, Paul L Martin, Kamar Godder, Christine N Duncan, Nahal R Lalefar, Erin M Kreml, Janet R Hume, Hisham Abdel-Azim, Caitlin Hurley, Geoffrey D E Cuvelier, Amy K Keating, Muna Qayed, James S Killinger, Julie C Fitzgerald, Rabi Hanna, Kris M Mahadeo, Troy C Quigg, Prakash Satwani, Paul Castillo, Shira J Gertz, Theodore B Moore, Benjamin Hanisch, Aly Abdel-Mageed, Rachel Phelan, Dereck B Davis, Michelle P Hudspeth, Greg A Yanik, Michael A Pulsipher, Imran Sulaiman, Leopoldo N Segal, Birgitta A Versluys, Caroline A Lindemans, Jaap J Boelens, Joseph L DeRisi
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation
Nature medicine
evidencebased medicine announced entry heralding new paradigm health care practices widely criticized lacking coherent theoretical basis paper presents first part threearticle series examining epistemological practical ethical dimensions strong ebm well considering alternatives promise potential solutions chronic conceptual practical problems focus details arguments evidence thoughtful debates last 30 years worthwhile keep mind overall trajectory modern thought strong ebm continues discredited positivist positions thus repeating major assumptions inadequacies transferred medical sphere vocabulary part 1 series examines development strong ebm clarifying critiquing somewhat discontinuous accounts scientific knowledge epistemology evidence differences statistical probability regard populations understanding health individuals claims direct transfer research findings clinical settingsall raises questions regarding application providerpatient decision making pedagogy policy