Rizwan Jouhar, Muhammad Adeel Ahmed, Artak Heboyan, Muhammad Faheemuddin, Seyed Ali Mosaddad, Naseer Ahmed
Analysis of shade-matching ability in dental students: a comparative study under clinical and correcting light conditions
BMC medical education
digital interventions including apps websites effective reducing alcohol consumption however many evidence theoryinformed evaluated tested effectiveness drink less app reducing alcohol consumption compared usual digital care uk twoarm parallel group doubleblind randomised controlled trial enrolled increasingandhigherrisk drinkers audit 8 uk motivated reduce alcohol consumption willing use digital intervention via online methods participants randomly assigned 11 using online algorithm receive web link download drink less app intervention nhs alcohol advice webpage usual digital care researchers masked group allocation participants followed one three six months primary outcome selfreported weekly alcohol consumption six months adjusting baseline consumption full analytic sample used analyses though missing data treated different ways primary preregistered intentiontotreat analysis assumed baselinecarriedforwards secondary preregistered analyses also focused full analytic sample used alternatives including multiple imputation last observation carried forwards trial registered isrctn registry isrctn64052601 07132020 03292022 5602 people randomly assigned drink less app n 2788 comparator n 2814 groups sixmonth followup rates 79 80 respectively primary preregistered conservative intentiontotreat approach assuming nonresponders drinking baseline levels consumption found nonsignificant greater reduction 098 units weekly alcohol consumption intervention group 6month followup 95 ci 267 070 data insensitive detect hypothesised effect bayes factor 117 data missing completely random 6month followup rates differing terms education occupation income therefore conducted preregistered sensitivity analysis using multiple imputation showing drink less app resulted 200unit greater weekly reduction 6month followup compared nhs alcohol advice webpage 95 ci 376 024 fewer 01 participants arms responded one three sixmonth followup reported adverse events linked participation trial drink less app may effective reducing alcohol consumption increasingandhigherrisk drinkers motivated reduce consumption nihr public health research programme