Kiho Im|Nora Maria Raschle|Sara A. Smith|P. Ellen Grant|Nadine Gaab
Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners
Harvard University|Centre for Cognitive Neuroscience|Harvard University|Universitäre Psychiatrische Kliniken Basel|Centre for Cognitive Neuroscience|Harvard University|Boston Children's Hospital|Centre for Cognitive Neuroscience|Harvard University
developmental dyslexia dd highly heritable previous studies observed reduced cortical volume white matter integrity functional alterations left posterior brain regions individuals dd primary sulcal pattern hypothesized relate optimal organization connections cortical functional areas determined prenatal development may reflect early genetically influenced brain development characterize sulcal pattern using graphbased pattern analysis investigate whether sulcal patterns parietotemporal occipitotemporal regions atypical elementary schoolage children dd prereadersbeginning readers preschoolerskindergarteners familial risk elementary schoolage children n malesfemales age range 1711 84155 months preschoolerskindergarteners 1615 5984 months pattern sulcal basin area left parietotemporal occipitotemporal regions significantly atypical sulcal basins smaller size children dd correlated reduced reading performance single nonword reading measures significantly atypical sulcal area pattern also confirmed younger preschoolerskindergarteners familial risk dd results provide support atypical early brain development dd suggest dd may originate altered organization connections cortical areas left posterior regions