Melissa Washington-Nortey, Kristen Granger, Kevin S Sutherland, Maureen Conroy, Navneet Kaur, Allyse Hetrick
Sustaining BEST in CLASS: Teacher-Reported Evidence-Based Practice Use with Students at Risk for Emotional and Behavioral Disorders Amidst the COVID-19 Pandemic
School mental health
relationship psychological stress altered skin immunity autophagyrelated genes atgs currently unclear psoriasis chronic skin inflammation unclear etiology characterized persistence recurrence immune dysregulation emotional disturbances recognized significant risk factors emerging clinical evidence suggests possible connection anxiety disorders heightened immune system activation altered skin immunity offering fresh perspective initiation psoriasis aim study explore potential shared biological mechanisms underlying comorbidity psoriasis anxiety disorders psoriasis anxiety disorders data obtained geo database list 3254 atgs obtained public database differentially expressed genes degs obtained taking intersection degs psoriasis anxiety disorder samples list atgs five machine learning algorithms used screening hub genes roc curve performed evaluate diagnostic performance gsea immune infiltration analysis network analysis carried seurat monocle algorithms used depict tcell evolution cellchat used infer signaling pathway keratinocytes immune cells four key hub genes identified diagnostic genes related psoriasis autophagy enrichment analysis showed genes indeed related cells autophagy immune regulation good diagnostic efficacy validated using singlecell rna sequencing analysis expanded understanding key cellular participants including inflammatory keratinocytes interactions immune cells found casp7 gene involved tcell development process correlated cells warranting investigation found anxiety disorders related increased autophagy regulation immune dysregulation inflammatory response reflected onset exacerbation skin inflammation hub gene involved process immune signaling immune regulation casp7 gene related development differentiation cells deserves study potential biomarkers psoriasis anxiety disorders identified expected aid prediction disease diagnosis development personalized treatments