Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse, Yukiko Asaka
Prevalence and Associated Factors of Pathological Internet Use and Online Risky Behaviors Among Japanese Elementary School Children
Journal of epidemiology
psilocybin related hallucinogenic compounds increasingly used human research however due limited information potential subjective side effects controlled medical use compounds remained controversial therefore analysed acute short longterm subjective effects psilocybin healthy humans pooling raw data eight doubleblind placebocontrolled experimental studies conducted 1999 2008 analysis included 110 healthy subjects received 14 oral doses psilocybin 45315 gkg body weight although psilocybin dosedependently induced profound changes mood perception thought selfexperience subjects described experience pleasurable enriching nonthreatening acute adverse drug reactions characterized strong dysphoria andor anxietypanic occurred two highest dose conditions relatively small proportion subjects acute adverse drug reactions successfully managed providing interpersonal support need psychopharmacological intervention followup questionnaires indicated subsequent drug abuse persisting perception disorders prolonged psychosis longterm impairment functioning subjects results suggest administration moderate doses psilocybin healthy highfunctioning wellprepared subjects context carefully monitored research environment associated acceptable level risk