DongHoon Kang, Dong-Soo Kwon
An ergonomic comfort workspace analysis of master manipulator for robotic laparoscopic surgery with motion scaled teleoperation system
The international journal of medical robotics + computer assisted surgery : MRCAS
predicting cellular responses perturbations requires interpretable insights molecular regulatory dynamics perform reliable cell fate control despite confounding nonlinearity underlying interactions growing interest developing machine learningbased perturbation response prediction models handle nonlinearity perturbation data interpretation terms molecular regulatory dynamics remains challenge alternatively meaningful biological interpretation logical network models boolean networks widely used systems biology represent intracellular molecular regulation however determining appropriate regulatory logic largescale networks remains obstacle due highdimensional discontinuous search space tackle challenges present scalable derivativefree optimizer trained metareinforcement learning boolean network models logical network model optimized trained optimizer successfully predicts anticancer drug responses cancer cell lines simultaneously providing insight underlying molecular regulatory mechanisms