Hanna van Waart|Martijn M. Stuiver|Wim H. van Harten|Edwin Geleijn|Jacobien M. Kieffer|Laurien M. Buffart|Marianne de Maaker?Berkhof|Epie Boven|J. G. Schrama|Maud M. Geenen|Jetske M. Meerum Terwogt|Aart van Bochove|Vera Lustig|Simone M. van den Heiligenberg|Carolien H. Smorenburg|Jeannette A.J.H. Hellendoorn-van Vreeswijk|Gabe S. Sonke|Neil K. Aaronson
Effect of Low-Intensity Physical Activity and Moderate- to High-Intensity Physical Exercise During Adjuvant Chemotherapy on Physical Fitness, Fatigue, and Chemotherapy Completion Rates: Results of the PACES Randomized Clinical Trial
Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research|Sint Lucas Andreas Hospital|The Netherlands Cancer Institute|EMGO Institute for Health and Care Research
evaluated effectiveness lowintensity homebased physical activity program oncomove moderate highintensity combined supervised resistance aerobic exercise program ontrack versus usual care uc maintaining enhancing physical fitness minimizing fatigue enhancing healthrelated quality life optimizing chemotherapy completion rates patients undergoing adjuvant chemotherapy breast cancerwe randomly assigned patients scheduled undergo adjuvant chemotherapy n 230 oncomove ontrack uc performancebased selfreported outcomes assessed random assignment end chemotherapy 6month followup used generalized estimating equations compare groups timeoncomove ontrack resulted less decline cardiorespiratory fitness p 001 better physical functioning p 001 less nausea vomiting p 029 031 respectively less pain p 003 011 respectively compared uc ontrack also resulted better outcomes muscle strength p 002 physical fatigue p 001 6month followup outcomes returned baseline levels three groups smaller percentage participants ontrack required chemotherapy dose adjustments uc oncomove groups p 002 intervention groups returned earlier p 012 well hours per week p 014 work control groupa supervised moderate highintensity combined resistance aerobic exercise program effective patients breast cancer undergoing adjuvant chemotherapy homebased lowintensity physical activity program represents viable alternative women unable unwilling follow higher intensity program