Mohammad Rafiee, Mahsa Jahangiri-Rad, Anoushiravan Mohseni-Bandpei, Elham Razmi
Impacts of socioeconomic and environmental factors on neoplasms incidence rates using machine learning and GIS: a cross-sectional study in Iran
Scientific reports
although cancer still second leading cause death worldwide basic research largely elucidated underlying mechanisms lead us deep laws animate inanimate nature review aims demonstrate cancer process profoundly affects reprograms fundamental principles concepts cellular life harnessing natural mechanisms biological evolution shown mutation selection drivers cancer formation progression mandatory consequences boltzmanns version second law thermodynamics stipulates entropy disorder according probability never decreases followed darwinian evolution filtering suitable geno karyotypes cancer research shown malignant cells develop gradually abruptly depending prevailing stress conditions similar principles observed evolution species referred micro macroevolution cancer cells related phylogenetically older forms life malignant transformation viewed reverse atavistic evolution accompanied typical rearrangement system information loss social behavior becomes obvious nature distinction made normal biology pathobiology instead everything follows rules natural evolution illustrates depth cancer problem may explain serious difficulties faced trying eradicate cancer