Isabelle Blanchette, Wael El-Deredy
An ERP investigation of conditional reasoning with emotional and neutral contents
Brain and cognition
patients multiple sclerosis ms commonly present musculoskeletal disorders characterized lower bone mineral density bmd muscle weakness however underlying etiology remains unclear objective identify shared pleiotropic genetic effects estimate causal relationship ms musculoskeletal disorders conducted linkage disequilibrium score regression ldsr colocalization mendelian randomization mr analyses using summary statistics recent largescale genomewide association studies gwas encompassing ms falls fractures frailty additional mr analyses explored causal relationship musculoskeletal risk factors bmd lean mass grip strength vitamin observed moderate genetic correlation ms falls rg 010 pvalue 001 ms fracture frailty ldsr analyses mr revealed ms causal association fracture frailty moderate association falls 1004 fdr qvalue 0018 performed colocalization analyses using nine snps exhibited significant associations ms falls mr two snps rs7731626 ankrd55 rs701006 os9 gene showed higher posterior probability colocalization pph4 0927 suggesting potential pleiotropic effects ms falls nine genes associated central nervous system development inflammation signaling pathways found potential pleiotropic genetic effects ms falls however analysis reveal causal relationship ms increased risks falls fractures frailty suggests musculoskeletal disorders frequently reported ms patients clinical studies likely attributed secondary factors associated disease progression treatment rather directly caused ms