Arvind S Narayanan, Kurt E Stoll, Lincoln F Pratson, Feng-Chang Lin, Christopher W Olcott, Daniel J Del Gaizo
Musculoskeletal Health Literacy is Associated With Outcome and Satisfaction of Total Knee Arthroplasty
The Journal of arthroplasty
abstract chemistry lithium enolates used demonstrate complex structures held together noncovalent bonds supramolecules may dramatically influence result seemingly simple standard reactions organic synthesis detailed structural data obtained crystallographic investigations numerous li enolates analogous derivatives remarkable features structures aggregation give dimers tetramers higher oligomers complexation metal centers solvent molecules chelating ligands hydrogenbond formation weak acids secondary amines anionoid part enolates presence nonpolar solvents supramolecules established nmrspectroscopic osmometric calorimetric measurements structures order magnitude interactions also reproduced abinitio calculations importantly supramolecules may productforming species synthetic reactions li enolates knowledge complex structures li enolates also improves understanding reactivity thus simple procedures developed avoid complications caused secondary amines formed concomitantly li enolates common methods mixtures achiral li enolates chiral li amides give rise enantioselective reactions solubilization lix observed especially multiply lithiated compounds effect exploited alkylations nmethylglycine sarcosine ch 2 groups openchain oligopeptides thus cyclic undecapeptide cyclosporine potent immunosuppressant converted thfsoluble hexalithio derivative without epimerization stereogenic centers alkylated variety electrophiles presence either excess lithiumdiisopropyl amide 30 equivalents lithium chloride depending nature lix additive new stereogenic center r configuration created peptide chain process structureactivity correlation series cyclosporine derivatives thus available discussed