Michael A Jinks, Mark Howard, Federica Rizzi, Stephen M Goldup, Andrew D Burnett, Andrew J Wilson
Direct Detection of Hydrogen Bonds in Supramolecular Systems Using 1H-15N Heteronuclear Multiple Quantum Coherence Spectroscopy
Journal of the American Chemical Society
porcine models frequently used burn healing studies however factors including anatomic location lack standardised wound methods impact interpretation wound data objectives study examine influence anatomical locations uniformity burn creation healing porcine burn models optimise burn parameters dorsal ventral surfaces ex vivo situ euthanized animals first used examine locationdependence burn depth contact time relationship locationdependent healing vivo examined using burn excisional wounds dorsal ventral caudal cranial locations lactate dehydrogenase ldh used assess burn depth wound reepithelialization found burn depth ventral skin significantly deeper dorsal skin identical thermal conditions compared burns created ex vivo burns created situ immediately postmortem significantly deeper ventral location live animals 2 12 burn wounds fully reepithelialized 14 days contrast complete reepithelialization excisional wounds among burn wounds cranialdorsal site exhibited faster healing caudaldorsal site study showed anatomical location important consideration consistency burn depth creation healing data support symmetric localization treatment control comparative assessment burn healing porcine models prevent misinterpretation results increase translatability findings humans