Laura A Nabors, Tina L Stanton-Chapman, Filiberto Toledano-Toledano
A University and Community-Based Partnership: After-School Mentoring Activities to Support Positive Mental Health for Children Who Are Refugees
International journal of environmental research and public health
cause treatment electrical status epilepticus sleep eses one epileptic encephalopathies childhood unclear aim study evaluate possible microstructural abnormalities brain using advanced magnetic resonance imaging mri techniques eses patients without genetic mutations research comprised 12 eses patients without structural thalamic lesions 6 genetic abnormalities 6 without 12 healthy children wholeexome sequencing used genetic mutation analysis brain mri data evaluated using tractusbased spatial statistics voxelbased morphometry local gyrification index subcortical shape analysis freesurfer volume cortical thickness data groups compared mean age control group 905 185 years whereas eses group 945 272 years compared control group eses patients showed higher mean thalamus diffusivity p 005 eses patients genetic mutations lower axial diffusivity superior longitudinal fasciculus gray matter volume entorhinal region accumbens area caudate putamen cerebral white matter outer cerebellar areas superior middle temporal cortical thickness increased eses patients study important terms presenting microstructural evaluation brain eses patients advanced mri analysis methods well comparing patients without genetic mutations findings may associated corticostriatal transmission ictogenesis epileptogenesis neuropsychiatric symptoms cognitive impairment cerebellar involvement eses expanded casegroup studies may help understand physiology corticothalamic circuitry etiopathogenesis develop secondary therapeutic targets eses