Kaori Ishii, Ai Shibata, Minoru Adachi, Yoshiyuki Mano, Koichiro Oka
Objectively Measured Sedentary Behavior, Obesity, and Psychological Well-Being: A Cross-Sectional Study of Japanese Schoolchildren
Journal of physical activity & health
sepsis organ malfunction disease may become fatal commonly accompanied severe complications multiorgan dysfunction patients already hospitalized high risk death due sepsis even though early diagnosis important technology clinical approaches available inadequate hence immediate necessity investigate biological markers sensitive specific reliable prompt detection sepsis reduce mortality improve patient prognosis mounting research data indicate ferroptosis contributes occurrence development prevention sepsis however specific regulatory mechanism ferroptosis remains elucidated research evaluated expression profiles ferroptosisrelated genes frgs diagnostic significance ferroptosisrelated classifiers sepsis collected three peripheral blood data sets septic patients integrated clinical examination data mrna expression profile patients identified 13 frgs sepsis coexpression network differential analysis optimal classifier tool sepsis constructed integrating variety machine learning algorithms two key genes atg16l1 src shown shared algorithms thus identified frg signature classifier tool exhibited satisfactory diagnostic efficiency training data set auc 0711 two external verification data sets auc 0961 auc 0913 rat cecal ligation puncture sepsis model vivo experiments verified involvement atg16l1 src early sepsis process findings confirm frgs may participate development sepsis ferroptosis related classifiers provide basis development new strategies early diagnosis sepsis discovery new potential therapeutic targets lifethreatening infections