Batool Ghavami, Zahra Sohrabi, Ziba RaisiDehkordi, Fatemeh Mohammadi
Relationship between reproductive health literacy and components of healthy fertility in women of the reproductive age
Journal of education and health promotion
alterations intestinal permeability implicated ulcerative colitis uc infliximab monoclonal antitumor necrosis factor alpha tnf antibody induce clinical response uc gene expression colonic biopsies taken responders nonresponders infliximab provide insight mechanisms altered intestinal permeability molecular level colonic biopsies n 18 antitnf nave uc patients n 8 normal controls n 80 active ulcerative colitis trial act 1 patients analyzed mrna expression using gene expression microarrays computational reverse causal reasoning applied build causal network models uc response nonresponse uc treatment quantitative reversetranscription polymerase chain reaction qpcr used confirm differentially expressed genes reverse causal reasoning mrna expression data antitnfnave uc normal samples provided mechanistic disease model biology gene expression observed uc mrna expression data act 1 study enabled construction mechanistic model describing biology nonresponders infliximab including evidence increased intestinal permeability compared normal responder samples gene expression changes identified central intestinal permeability dysregulation confirmed normal uc infliximabtreated patients qpcr analysis gene expression returned toward normal levels infliximab responders nonresponders gene expression analysis causal network modeling combination showed aberrant mrna expression genes involved intestinal epithelial permeability infliximab responders restored toward levels observed normal samples infliximab nonresponders showed equivalent restoration expression genes