Nicole Senft|Lauren M. Hamel|Mark Manning|Seongho Kim|Louis A. Penner|Tanina Foster Moore|Michael A. Carducci|Elisabeth I. Heath|Dina Lansey|Terrance L. Albrecht|Mark Wojda|Alice Jordan|Susan Eggly
Willingness to Discuss Clinical Trials Among Black vs White Men With Prostate Cancer
Vanderbilt University Medical Center|The Barbara Ann Karmanos Cancer Institute|Wayne State University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|Sidney Kimmel Comprehensive Cancer Center|Johns Hopkins University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|Sidney Kimmel Comprehensive Cancer Center|Johns Hopkins University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|The Barbara Ann Karmanos Cancer Institute|Wayne State University|Sidney Kimmel Comprehensive Cancer Center|Johns Hopkins University|The Barbara Ann Karmanos Cancer Institute|Wayne State University
h3importanceh3 black individuals underrepresented cancer clinical trials h3objectiveh3 examine whether black white men prostate cancer differ willingness discuss clinical trials physicians whether patientlevel barriers statistically mediate racial differences h3design setting participantsh3 crosssectional survey study used baseline data partnering around cancer clinical trials randomized clinical trial increase black individuals enrollment prostate cancer clinical trials data collected 2016 2019 2 national cancer institutedesignated comprehensive cancer centers participants black white men intermediaterisk highrisk prostate cancer mediation analysis path models regressed willingness onto race potential mediator simultaneously including direct paths race mediator significant indirect effect sizes served evidence mediation h3exposuresh3 race primary exposure potential mediators included age education household income perceived economic burden painphysical limitation health literacy general trust physicians groupbased medical suspicion h3main outcomes measuresh3 primary outcome answer single question offered cancer clinical trial would willing hear information h3resultsh3 total 205 participants included 92 black men 113 white men mean range age 657 4589 years 32 high school education lower 275 household income less 40 000 883 reported definitely probably willing discuss trials white participants likely endorse highest category willingness black participants 82 vs 64 sup2supsub2sub 881ipi 01 compared white participants black participants younger ifisub1182sub 867ipi lt 001 less educated ifisub1182sub 2279ipi lt 001 lower income ifisub1182sub 7959ipi lt 001 greater perceived economic burden ifisub1182sub 4246ipi lt 001 lower health literacy ifisub1184sub 984ipi 002 greater groupbased medical suspicion ifisub1184sub 2148ipi lt 001 groupbased medical suspicion significantly mediated association race willingness discuss trials indirect effect 022ipi 002 h3conclusions relevanceh3 study men prostate cancer participants willing discuss trials black men significantly less willing white men black men likely believe members racial group suspicious health care system belief associated lower willingness discuss trials addressing medical mistrust may improve equity clinical research