Bryce A Ringwald, Stephen Auciello, Joseph Ginty, Melissa Jefferis, Stephen Stacey
Administrative Time Expectations for Residency Core Faculty: A CERA Study
Family medicine
automated signal generation growing field pharmacovigilance relies data mining huge spontaneous reporting systems detecting unknown adverse drug reactions adr previous implementations quantitative techniques take account issues related medical dictionary regulatory activities meddra terminology used coding adrs meddra first generation terminology lacking formal definitions grouping similar medical conditions accurate due taxonomic limitations objective build datamining tool improves signal detection algorithms performing terminological reasoning meddra codes described damloil description logic propose pharmaminer tool implements quantitative techniques based underlying statistical bayesian models java application displaying results tabular format performing terminological reasoning racer inference engine mean frequency drugadverse effect associations french database 266 subsumption reasoning based meddra taxonomical hierarchy produced mean number occurrence 292 versus 363 p 0001 obtained combined technique using subsumption approximate matching reasoning based ontological structure semantic integration terminological systems data mining methods promising technique improving machine learning medical databases