Liza?Marie Johnson|April Sykes|Zhaohua Lu|Jessica M. Valdez|Jami Gattuso|Elsie L. Gerhardt|Kayla V. Hamilton|Lyn Harrison|Stacy J. Hines?Dowell|Niki Jurbergs|Rose B. McGee|Regina Nuccio|Annastasia Ouma|Michele Pritchard|Emily A. Quinn|Justin N. Baker|Belinda N. Mandrell|Kim E. Nichols
Speaking genomics to parents offered germline testing for cancer predisposition: Use of a 2?visit consent model
St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|University of New Mexico|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|Keck Graduate Institute|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital
background patients cancer increasingly offered genomic sequencing including germline testing cancer predisposition disorders testing unfamiliar patients families clear communication needed introduce genomic concepts convey risk benefit information methods parents children cancer offered opportunity childrens tumor germline examined clinical genomic sequencing families introduced study 2visit informed consent model baseline genetic knowledge selfreported literacynumeracy collected study introduction visit basic concepts related genomic sequencing discussed information reinforced second visit informed consent obtained posttest administered results reflected percentage correct answers pretest posttest assessments model increased genetic knowledge 111 778 889 p lt 0001 121 parents participating study introduction consent visits percentage parents correctly identifying meaning somatic germline mutations increased significantly 18 59 somatic 31 64 germline p lt 0001 nevertheless concepts remained unfamiliar onethird parents relation identified change overall percentage correct answers selfreported literacy numeracy demographics conclusions use 2visit communication model improved knowledge concepts relevant genomic sequencing particularly differences somatic germline testing however areas remained confusing many participants reinforcement may necessary achieve complete understanding