Carolyn R Pagán, Maureen Schmitter-Edgecombe
Health literacy in older adults: The newest vital sign and its relation to cognition and healthy lifestyle behaviors
Applied neuropsychology. Adult
annotation enrichment analysis aea widely used analytical approach process data generated highthroughput genomic proteomic experiments gene expression microarrays analysis uncovers summarizes discriminating background information eg go annotations sets genes identified experiments eg set differentially expressed genes cluster discovered information utilized human experts find biological interpretations experiments however aea isolates tests overrepresentation individual annotation terms groups similar terms limited ability uncover complex phenomena involving relationship multiple annotation terms various knowledge bases also aea assumes annotations describe whole object interest makes difficult apply sets compound objects eg sets proteinprotein interactions sets objects internal structure eg protein complexes propose novel logicbased annotation concept synthesis enrichment analysis acsea approach acsea fuses inductive logic reasoning statistical inference uncover complex phenomena captured experiments evaluate approach largescale datasets several microarray experiments clustered genomewide genetic interaction network using different biological knowledge bases discovered interpretations lower pvalues interpretations found aea highly integrative nature include analysis quantitative structured information present knowledge bases results suggest acsea boost effectiveness processing highthroughput experiments mjilinesiteuottawaca