Claudia Orozco-Rodriguez, Abel Palafox González, Carlos Valenzuela García
A realistic situation, proposed from data generated within the GeOrder Simulator to elicit the statistical reasoning
Heliyon
mathematical models cardiac cell started include markovian representations ionic channels instead traditional hodgkin huxley formulations many reasons markov models restricted idea independent gates defining channel allow complex description specific transitions open closed inactivated states importantly states closely related underlying channel structure conformational changes used labview matlab programs implement simulator markolab allow dynamical 3d representation markovian model channel monte carlo simulation used implement stochastic transitions among states user specify voltage protocol setting holding potential stepto voltage duration stimuli studied feature channel current flowing happens channel stays open state time revealed low open probability values channel remains inactive closed states focusing channel enters leaves open state missing activity markolab proved quite useful visualize whole behavior channel channel produces current dynamic representation provides complete information channel kinetics powerful tool demonstrate effect gene mutations drugs channel function markolab provides original way visualizing stochastic behavior channel clarifies concepts recovery inactivation calcium versus voltagedependent inactivation tail currents restricted ionic channels extended transporters exchangers pumps program intended didactical tool illustrate dynamical behavior channel implemented two platforms matlab labview enhance target users new didactical tool computational cost implementing stochastic simulation within range personal computer performance making markolab suitable run lecture presentation