Christopher Le, Øystein Guttersrud, Kristine Sørensen, Hanne Søberg Finbråten
Developing the HLS19-YP12 for measuring health literacy in young people: a latent trait analysis using Rasch modelling and confirmatory factor analysis
BMC health services research
primary objective pharmacokineticpharmacodynamic pkpd reasoning identify key vivo drug system properties enabling prediction magnitude time course drug responses physiological pathological conditions animals man since pharmacological response generated drug highly dependent actual system used study action knowledge potency efficacy given concentration dose insufficient obtain proper understanding pharmacodynamic profile hence output pkpd activities extends beyond provision quantitative measures models results design future protocols furthermore pkpd integrates dmpk eg clearance pharmacology eg potencyit provides anchor point compound selection viewed important weapon medicinal chemistry outline key pk concepts relevant pd consider reallife experiments illustrate importance medicinal chemist data obtained pkpd useful assumptions potential pitfalls described providing holistic view plethora determinants behind vitroin vivo correlations condensing complexity simplicity consequences experimental design ranking design compounds also possible make important predictions impact changes drug potency kinetics short using quantitative methods tease apart pharmacodynamic complexities temporal differences changes plasma protein binding possible target changes necessary improving compounds profile