Smita Bhatia|Wendy Landier|Lindsey Hageman|Heeyoung Kim|Yanjun Chen|Kristine R. Crews|William E. Evans|Bruce Bostrom|Jacqueline Casillas|David Dickens|Kelly W. Maloney|Joseph P. Neglia|Yaddanapudi Ravindranath|A. Kim Ritchey|F. Lennie Wong|Mary V. Relling
6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study
City of Hope|City of Hope|City of Hope|City of Hope|City of Hope|St. Jude Children's Research Hospital|St. Jude Children's Research Hospital|Children's Minnesota|University of California, Los Angeles|Helen DeVos Children's Hospital|Corewell Health Blodgett Hospital|Spectrum Health|University of Colorado Denver|University of Minnesota Medical Center|Children's Hospital of Michigan|Children's Hospital of Pittsburgh|University of Pittsburgh Medical Center|City of Hope|St. Jude Children's Research Hospital
durable remissions children acute lymphoblastic leukemia require 2year maintenance phase includes daily oral 6mercaptopurine 6mp adherence oral 6mp among asianamerican africanamerican children unknown enrolled 298 children 71 asian americans 68 african americans 159 nonhispanic whites receiving oral 6mp maintenance phase adherence measured electronically 39 803 persondays adherence declined 950 month 1 918 month 5 p 0001 adherence rates significantly p 0001 lower asian americans 900 49 african americans 871 44 compared nonhispanic whites 952 13 racespecific sociodemographic characteristics helped explain poor adherence african americans low maternal education less college degree 789 vs least college degree 946 p 0001 asian americans lowincome households 50 000 845 vs 50 000 967 p 04 households without mothers fulltime caregivers 856 vs households mothers fulltime caregivers 972 p 05 adherence rate 90 associated increased relapse risk hazard ratio 39 p 01 using adherence rate 90 define nonadherence 205 participants nonadherers identify racespecific determinants adherence define clinically relevant level adherence needed minimize relapse risk multiracial cohort children trial registered wwwclinicaltrialsgov nct00268528