Zahra Dadras, Behnam Molaei, Masoumeh Aghamohammadi
The relationship between personality profile and self-care among patients with type 2 diabetes
Frontiers in psychology
subset patients gastric cancer experience longterm benefits immune checkpoint inhibitors icis currently deficiency precise predictive biomarkers ici efficacy aim study develop validate pathomicsdriven ensemble model predicting response icis gastric cancer using hestained whole slide images wsi multicenter study retrospectively collected analyzed hestained wsis clinical data 584 patients gastric cancer ensemble model integrating four classifiers least absolute shrinkage selection operator knearest neighbors decision trees random forests developed validated using pathomics features objective predicting therapeutic efficacy immune checkpoint inhibition model performance evaluated using metrics including area curve auc sensitivity specificity additionally shap shapley additive explanations analysis used explain models predicted values sum attribution values input feature pathogenomics analysis employed explain molecular mechanisms underlying models predictions pathomicsdriven ensemble model effectively stratified response icis training cohort auc 0985 95 ci 0971 0999 validated internal validation cohort auc 0921 95 ci 0839 0999 well external validation cohort 1 auc 0914 95 ci 0837 0990 external validation cohort 2 0927 95 ci 0802 0999 univariate cox regression analysis revealed prediction signature pathomicsdriven ensemble model prognostic factor progressionfree survival patients gastric cancer underwent immunotherapy p0001 hr 035 95 ci 024 050 remained independent predictor multivariable cox regression adjusted clinicopathological variables including sex age carcinoembryonic antigen carbohydrate antigen 199 therapy regime line therapy differentiation location programmed death ligand 1 pdl1 expression patients p0001 hr 034 95 ci 024 050 pathogenomics analysis suggested ensemble model driven molecularlevel immune cancer metabolismrelated pathways correlated immunerelated characteristics including immune score estimation stromal immune cells malignant tumor tissues using expression data score tumor purity pathomicsdriven ensemble model exhibited high accuracy robustness predicting response icis using wsis therefore could serve novel valuable tool facilitate precision immunotherapy