Alexis Boyd|Kimberly Y. Won|Shannon McClintock|Catherine Donovan|Sandra J. Laney|Steven A. Williams|Nils Pilotte|Thomas G. Streit|Madsen V. E. Beau de Rochars|Patrick J. Lammie
A Community-Based Study of Factors Associated with Continuing Transmission of Lymphatic Filariasis in Leogane, Haiti
Centers for Disease Control and Prevention|Centers for Disease Control and Prevention|Centers for Disease Control and Prevention|University of Notre Dame|Smith College|Smith College|Smith College|University of Notre Dame|Centers for Disease Control and Prevention
seven rounds mass drug administration mda administered leogane haiti area hyperendemic lymphatic filariasis lf sentinel site surveys showed prevalence microfilaremia reduced 1 levels high 155 suggesting transmission reduced separate 30cluster survey 2 4yearold children conducted determine mda interrupted transmission antigen antifilarial antibody prevalence 143 197 respectively followup surveys done 6 villages including selected cluster survey assess risk factors related continued lf transmission pinpoint hotspots transmission one hundred houses mapped village using gpsenabled pdas 30 houses 10 alternates chosen testing individuals selected houses asked participate short survey participation mda history residence leogane general knowledge lf survey teams returned houses night collect blood antigen testing microfilaremia bm14 antibody testing collected mosquitoes communities parallel antigen prevalence highly variable among 6 villages highest 382 dampus lowest 29 corail lemaire overall antigen prevalence 185 initial cluster surveys 2 4yearold children related community antigen prevalence nearest neighbor analysis found evidence clustering infection suggesting lf infection focal distribution antigen prevalence among individuals systematically noncompliant mdas ie never participated significantly higher among compliant individuals p005 logistic regression model found factors examined association infection noncompliance significantly associated infection thus continuing transmission lf seems linked rates systematic noncompliance