Yu Jinhai, Gan Jiancheng, Zhang Huang, Wang Yaohua, Xu Qihua, Liao Hongfei
Analysis of postoperative complications of orbital fracture
Oral and maxillofacial surgery
microbial secondary metabolites play crucial role intricate interactions within natural environment among metabolites ribosomally synthesized posttranslationally modified peptides ripps becoming promising source therapeutic agents due structural diversity functional versatility however biosynthetic capacity ecological functions remain largely underexplored aim explore biosynthetic profile ripps potential roles interactions microbes viruses ocean encompasses vast diversity unique biomes rich interactions remains chemically underexplored first developed trripp identify ripps ocean metagenomes deep learning method detects ripp precursors hallmark geneindependent manner overcome limitations classic methods processing highly fragmented metagenomic data applying method metagenomes global ocean microbiome uncover diverse array previously uncharacterized putative ripp families great novelty diversity correlation analysis based metatranscriptomic data observed high prevalence antiphage defenserelated phagerelated protein families coexpressed ripp families based putative association ripps phage infection constructed ocean virus database ovd established rippinvolving hostphage interaction network host prediction coexpression analysis revealing complex connectivities linking rippencoding prokaryotes ripp families viral protein families phages findings highlight potential ripp families involved prokaryotephage interactions coevolution providing insights ecological functions ocean microbiome study provides systematic investigation biosynthetic potential ripps ocean microbiome global scale shedding light essential insights ecological functions ripps prokaryotephage interactions integration deep learning approaches metatranscriptomic data hostphage connectivity study serves valuable example exploring ecological functions bacterial secondary metabolites particularly associations unexplored microbial interactions video abstract