Eric Yoon|Arooj Babar|Manoj K. Choudhary|Matthew Kutner|Nikolaos Pyrsopoulos
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
University Hospital, Newark|Rutgers, The State University of New Jersey|University Hospital, Newark|Rutgers, The State University of New Jersey|University Hospital, Newark|Rutgers, The State University of New Jersey|University Hospital, Newark|Rutgers, The State University of New Jersey|University Hospital, Newark|Rutgers, The State University of New Jersey
hepatic injury subsequent hepatic failure due intentional nonintentional overdose acetaminophen apap affected patients decades involves cornerstone metabolic pathways take place microsomes within hepatocytes apap hepatotoxicity remains global issue united states particular accounts 50 overdoserelated acute liver failure approximately 20 liver transplant cases pathophysiology disease course management acute liver failure secondary apap toxicity remain precisely elucidated adverse patient outcomes increased morbidity mortality continue occur although apap hepatotoxicity follows predictable timeline hepatic failure clinical presentation might vary nacetylcysteine nac therapy considered mainstay therapy liver transplantation might represent lifesaving procedure selected patients future research focus field may benefit shifting towards obtaining antidotal knowledge molecular level focus underlying molecular signaling pathways