Christopher Osterhaus, Susanne Koerber
The personal epistemology of parents predicts the development of scientific reasoning in children aged 6-10 years
Developmental science
balance benefits risks discordant outcomes makes genomewide noninvasive prenatal test gwnipt controversial study aims evaluate performance clinical utility wide cohort unselected clinical cases single center standardized protocol applied integrated secondary algorithm data interpretation 2 years 70000 pregnant patients underwent gwnipt fetal common trisomies sex chromosome aneuploidies rare autosomal aneuploidies segmental abnormalities cnvs 7 mb microdeletions cnvs 7 mb samples uniformly processed veriseq nipt solution v2 analyzed using data metrics along homemade algorithm sequencing data analysis results retrospectively reviewed clinical outcomes among 71883 eligible cases including twin pregnancies 1011 14 received positive result 781 confirmed invasive prenatal diagnosis clinical sensitivity ranged 9965 common trisomy t21 t18 t13 8333 microdeletions specificity remained high 9998 class fetal abnormalities detected integrating standardized protocol internal algorithm allowed discordant results reduced yielding high accuracy observed reliability detecting genomewide chromosomal conditions reinforced expanded nipt utility clinical practice