Peter N. Taylor|Onyebuchi Okosieme|Colin Dayan|John H. Lazarus
THERAPY OF ENDOCRINE DISEASE: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis
Cardiff University|Cardiff University|Cardiff University|Cardiff University
background although detrimental effects severe iodine deficiency well recognised benefits correcting mildtomoderate iodine deficiency uncertain objectives undertook systematic review impact iodine supplementation populations mildtomoderate iodine deficiency methods searched medline cochrane library relevant articles published january 1966 april 2013 investigated effect iodine supplementation maternal newborn thyroid function infant neurodevelopment cognitive performance schoolage children quality studies graded eligible trials evaluated metaanalysis results nine randomised controlled trials rcts eight observational studies met inclusion criteria controlled trials infant neurodevelopment lacking gestational iodine supplementation reduced maternal thyroid volume serum thyroglobulin studies prevented rise serum thyroidstimulating hormone none intervention trials recorded excess frequency thyroid dysfunction contrast observational studies pooled analysis two rcts measured cognitive function schoolage children showed modest benefits iodine supplementation perceptual reasoning standardised mean difference smd 055 95 ci 005 104 p 003 global cognitive index smd 027 95 ci 010 044 p 0002 significant heterogeneity studies conclusion iodine supplementation improves maternal thyroid indices may benefit aspects cognitive function schoolage children even marginally iodinedeficient areas large prospective controlled studies urgently required clarify findings quantify riskbenefits iodine supplementation regions previously believed iodine sufficient uk