Catherine M. Calvin|G. David Batty|Geoff Der|Clare Brett|Adele M. Taylor|Alison Pattie|Iva ?uki?|Ian J. Deary
Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study
Warneford Hospital|University of Oxford|University of Edinburgh|University College London|University of Edinburgh|University of Edinburgh|MRC/CSO Social and Public Health Sciences Unit|University of Glasgow|Liverpool John Moores University|University of Edinburgh|University of Edinburgh|University of Edinburgh|University of Edinburgh|University of Edinburgh
bobjectivesbnbspto examine association intelligence measured childhood leading causes death men women life course bdesignbnbspprospective cohort study based whole population participants born scotland 1936 linked mortality data across 68 years followup bsettingbnbspscotland bparticipantsbnbsp33 536 men 32 229 women participants scottish mental survey 1947 sms1947 could linked cause death data december 2015 bmain outcome measuresbnbspcause specific mortality including coronary heart disease stroke specific cancer types respiratory disease digestive disease external causes dementia bresultsbnbspchildhood intelligence inversely associated major causes death age sex adjusted hazard ratios 95 confidence intervals per 1 sd 15 points advantage intelligence test score strongest respiratory disease 072 070 074 coronary heart disease 075 073 077 stroke 076 073 079 notable associations plt0001 observed deaths injury 081 075 086 smoking related cancers 082 080 084 digestive disease 082 079 086 dementia 084 078 090 weak associations apparent suicide 087 074 102 deaths cancer related smoking 096 093 100 confidence intervals included unity suggestion childhood intelligence somewhat strongly related coronary heart disease smoking related cancers respiratory disease dementia women men p value interactions lt0001 002 lt0001 002 respectivelybbchildhood intelligence related selected cancer presentations including lung 075 072 077 stomach 077 069 085 bladder 081 071 091 oesophageal 085 078 094 liver 085 074 097 colorectal 089 083 095 haematopoietic 091 083 098 sensitivity analyses representative subsample cohort observed small attenuation estimated effect intelligence 1026 adjustment potential confounders including three indicators childhood socioeconomic status replication sample scotland similar birth year cohort followup period smoking adult socioeconomic status partially attenuated 1658 association intelligence outcome rates bconclusionsbnbspin whole national population year birth cohort followed life course age 11 age 79 higher scores well validated childhood intelligence test associated lower risk mortality ascribed coronary heart disease stroke cancers related smoking particularly lung stomach respiratory diseases digestive diseases injury dementia