Michael P. Rethman|Eugenio D. Beltrán?Aguilar|Ronald J. Billings|Philippe Hujoel|Barry P. Katz|Peter Milgrom|Woosung Sohn|John W. Stamm|Gene E. Watson|Mark Wolff|J Tim Wright|Domenick T. Zero|Krishna Aravamudhan|Julie Frantsve?Hawley|Daniel M. Meyer
Nonfluoride caries-preventive agents
The Ohio State University
backgroundin article authors present evidencebased clinical recommendations regarding use nonfluoride cariespreventive agents recommendations developed expert panel convened american dental association ada council scientific affairs panel addressed several questions regarding efficacy nonfluoride agents reducing incidence caries arresting reversing progression cariestypes studies revieweda panel experts convened ada council scientific affairs collaboration ada division science staff conducted medline search identify randomized nonrandomized clinical studies regarding use nonfluoride cariespreventive agentsresultsthe panel reviewed evidence 50 randomized controlled trials 15 nonrandomized studies assess efficacy various nonfluoride cariespreventive agentsclinical implicationsthe panel concluded certain nonfluoride agents may provide benefit adjunctive therapies children adults higher risk developing caries recommendations presented resource dentists consider clinical decisionmaking process part evidencebased approach care clinical recommendations integrated practitioneraposs professional judgment patientaposs needs preferences full report accessed httpebdadaorgclinicalrecommendationsaspx