Ioanna Talli, Panagiota Kotsoni, Stavroula Stavrakaki, Liliane Sprenger-Charolles
Assessing phonological short-term memory in Greek: Reliability and validity of a non-word repetition test
Frontiers in psychology
polypharmacy use 5 daily medications common adults multiple sclerosis ms often due various physical cognitive emotional symptoms however research regarding association polypharmacy cognitive outcomes ms sparse furthermore individuals ms often use medications anticholinergic properties commonly associated cognitive impairment central nervous system adverse effects currently utility scales measuring anticholinergic burden ms unknown study aims investigate relationship polypharmacy anticholinergic burden objective cognitive performance ms recruited 90 individuals ms routine visits ms specialty clinic kansas city participants completed brief virtual cognitive assessment answered questions health participants provided medication lists determined polypharmacy scores several anticholinergic burden scales statistical analyses included spearman correlations linear regression models approximately 44 individuals surveyed met criteria polypharmacy number daily medications negatively correlated cognitive performance rs 045 p 001 drug burden index accounted additional variance cognitive performance beyond explained age education ms disease duration comorbidities r2 12 f5 84 784 p 001 clinicians consider possible negative consequences polypharmacy addressing cognitive concerns ms anticholinergic burden scales may valuable regard future investigations could explore behavioral pharmacological interventions aimed reducing polypharmacy ms