Kirsty Hodgson, Margarita Orozco-Moreno, Emily Archer Goode, Matthew Fisher, Rebecca Garnham, Richard Beatson, Helen Turner, Karen Livermore, Yuhan Zhou, Laura Wilson, Eline A Visser, Johan Fa Pijnenborg, Nienke Eerden, Sam J Moons, Emiel Rossing, Gerald Hysenaj, Rashi Krishna, Ziqian Peng, Kyla Putri Nangkana, Edward N Schmidt, Adam Duxfield, Ella P Dennis, Rakesh Heer, Michelle A Lawson, Matthew Macauley, David J Elliott, Christian Büll, Emma Scott, Thomas J Boltje, Richard R Drake, Ning Wang, Jennifer Munkley
Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone
EBioMedicine
existing studies disease diagnostic models focus either diagnostic model learning performance improvement visual explanation trained diagnostic model propose novel learnexplainreinforce lear framework unifies diagnostic model learning visual explanation generation explanation unit trained diagnostic model reinforcement reinforcement unit guided visual explanation visual explanation generate counterfactual map transforms input sample identified intended target label example counterfactual map localize hypothetical abnormalities within normal brain image may cause diagnosed alzheimers disease ad believe generated counterfactual maps represent datadriven knowledge target task ie ad diagnosis using structural mri vital source information reinforce generalization trained diagnostic model end devise attentionbased feature refinement module guidance counterfactual maps explanation reinforcement units reciprocal operated iteratively proposed approach validated via qualitative quantitative analysis adni dataset comprehensibility fidelity demonstrated ablation studies comparisons existing methods