Maki Koyama|David O’Connor|Zarrar Shehzad|Michael P. Milham
Differential contributions of the middle frontal gyrus functional connectivity to literacy and numeracy
Nathan Kline Institute for Psychiatric Research|Child Mind Institute|Yale University|Child Mind Institute
literacy numeracy equally affect individuals success beyond schools two competencies tend separately examined particularly neuroimaging studies current restingstate fmri study examined neural correlates literacy numeracy sample healthy adults first used exploratory multivariate distance matrix regression mdmr approach examine intrinsic functional connectivity ifc highlighting middle frontal gyrus mfg competencies notably hemispheric asymmetry mdmrbased mfg findings literacy associated left mfg whereas numeracy associated right mfg rmfg results posthoc seedbased correlation analyses strengthened differential contributions mfg connections competency one striking novel findings present work numeracy negatively related rmfg connections default network largely overlooked literature results largely consistent prior neuroimaging work showing distinct neural mechanisms underlying literacy numeracy also indicate potentially common ifc profiles competencies eg rmfg cerebellum taken together ifc findings potential provide novel insights neural bases literacy numeracy impairments competencies