Jinseon Yi, Ju Young Yoon, Chang Won Won, Miji Kim, Kyoung Suk Lee
The roles of health literacy and social support in the association between smartphone ownership and frailty in older adults: a moderated mediation model
BMC public health
alzheimers disease ad neurodegenerative condition currently available medication stop progression previous studies suggest mild cognitive impairment mci phase precedes disease therefore better understanding molecular mechanisms behind mci conversion ad needed propose machine learningbased approach detect key metabolites proteins involved mci progression ad using data european medical information framework alzheimers disease multimodal biomarker discovery study proteins metabolites evaluated separately multiclass models controls mci ad together mci conversion models mci stable vs converter features selected relevant 34 algorithms proposed kept downstream analysis multiclass models metabolites highlighted nine features validated independent cohort 0726 mean balanced accuracy among features one metabolite oleamide selected algorithms invitro experiments rodents showed diseaseassociated microglia excreted oleamide vesicles multiclass models proteins stood nine features validated independent cohort 0720 mean balanced accuracy however none proteins selected algorithms besides distinguish mci stable converters 14 key features selected 0872 auc including ttau alphasynuclein snca junctophilin3 jph3 properdin cfp peptidase inhibitor 15 pi15 among others omics integration approach highlighted set molecules associated mci conversion important neuronal glia inflammation pathways