Allison F O'Neill, Alanna J Church, Angela Feraco, Jennifer Spidle, Catherine B Wall, Heung Bae Kim, Scott Elisofon, Khashayar Vakili, Max Pimkin, Neekesh V Dharia, Nathan R Shelman, Antonio R Perez-Atayde, Carlos Rodriguez-Galindo
Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series
EBioMedicine
family physicians perceive gut feelings ie sense reassurance sense alarm play substantial role diagnostic reasoning measuring instrument desirable research objective validate questionnaire measuring presence gut feelings diagnostic reasoning constructed 16 case vignettes real practice situations used accompanying sense reassurance sense alarm reference labels based results initial study 26 family physicians divided case vignettes group involving clear role sense reassurance sense alarm group involving ambiguous role 49 experienced family physicians evaluated 10 vignettes using questionnaire construct validity assessed testing hypotheses internal consistency procedure performed hypothesized found correlations reference labels corresponding items high clearcase vignettes 059 072 low ambiguouscase vignettes 008 023 agreement classification clear sense reassurance clear sense alarm ambiguous case vignettes derived initial study study populations judgments substantial kappa 062 factor analysis showed one factor opposites sense reassurance sense alarm items questionnaires internal consistency high 091 provided linguistic validated englishlanguage text questionnaire questionnaire appears valid enables quantitative research role gut feelings diagnostic value family physicians diagnostic reasoning