Roy Phitayakorn, Todd A Schwartz, Gerard M Doherty
Practical Guide to Experimental and Quasi-Experimental Research in Surgical Education
JAMA surgery
bronchial asthma ba common chronic respiratory disease worldwide earlier research demonstrated abnormal functional connectivity fc multiple cognitionrelated cortices asthma patients thalamus thal serves relay center transmitting sensory signals yet modifications thalamic fc among individuals asthma remain uncertain research employed restingstate functional connectivity rsfc approach explore alterations thalamic functional connectivity among individuals ba excluding participants meet criteria study finally included 31 patients ba gender distribution 16 males 15 females subsequently recruited 31 healthy control participants hc matched age gender educational background participants underwent montreal cognitive assessment moca hamilton depression rating scale hamd assessment following groups underwent head magnetic resonance imaging scans restingstate functional magnetic resonance imaging rsfmri data collected based aal automated anatomical labeling template bilateral thalamic regions used seed points roi subsequent rsfc research pearson correlation analysis used explore relationship thalamic functional connectivity neuropsychological scales groups controlling potential confounding factors age gender intelligence emotional level twosample ttest used explore differences thalamic functional connectivity two groups participants compared hc group ba group demonstrated heightened functional connectivity fc left thalamus left cerebellar posterior lobe cpl left postcentral gyrus pcg right superior frontal gyrus sfg concurrently decrease fc lentiform nucleus ln left corpus callosum cc performing fc analysis right thalamus region interest roi revealed increase fc right thalamus right sfg well left cpl conversely decrease fc observed right thalamus right ln well left cc study verified presence aberrant fc patterns thalamus ba patients compared hcs ba patients exhibit aberrant alterations fc thalamus various brain areas connected vision hearing emotional regulation cognitive control somatic sensations wakefulness provides confirmation substantial role played thalamus advancement ba