Isaac Amankwaa|Daniel Boateng|Dan Yedu Quansah|Cynthia Pomaa Akuoko|Catrin Evans
Effectiveness of short message services and voice call interventions for antiretroviral therapy adherence and other outcomes: A systematic review and meta-analysis
Wellington Hospital|Victoria University of Wellington|University Medical Center Utrecht|Utrecht University|Kwame Nkrumah University of Science and Technology|University of Lausanne|University of Cape Coast|Christian Service University College|Queensland University of Technology|Queen's Medical Centre|University of Nottingham
background potential using mobile phone technologies improve antiretroviral therapy art adherence provided new facet human immunodeficiency virus hiv research quality evidence strength recommendations existing reviews however adequately support largescale adoption intervention review adopted broad selection criteria include mobile phonebased interventions designed improve patients adherence art methods performed systematic review metaanalysis randomized controlled trials quasiexperimental studies pubmed medline embase psychinfo cochrane central register controlled trials central cinahl amed web science searched online abstracts archives relevant conference proceedings trial registries also searched thirtyfive 35 fulltext articles assessed eligibility included studies conducted high low middleincome countries reported art adherence interventions delivered mobile phones standard smartphones form voice calls interactive voice response calls ivr short message service sms results thirteen 13 studies met inclusion criteria 11 used metaanalysis intervention characteristics included studies ranged mobile phone functionalities provision study phones participants sms voice call contents tailored participants specific adherence needs mobile sms interventions improved adherence art compared control conditions 95 ci 159 127198 subgroup analysis scheduled sms significant whereas triggered sms effect adherence art mobile voice calls significantly increase adherence art interventions highly rated 90 participants studies reported experiences satisfaction intervention conclusion scheduled mobile phone textmessaging demonstrated significant improvement adherence art mobile sms adherence interventions allow twoway communication may however acceptable standalone sms reminders seen intrusive producing habituation response fatigue voice calls triggered sms functionalities significant effect adherence art although higher preference voice functionality sms especially limitedresource lowliteracy settings exploration mobile voice functionality possible combination scheduled sms functionality recommended evidence provided study guide implementation mobile phone intervention improve adherence art addressing practical challenges could militate scalability especially resource limited settings