Lorena Ruíz|Irene Espinosa?Martos|Cristina García-Carral|Susana Manzano|Michelle K. McGuire|Courtney L. Meehan|Mark A. McGuire|Janet E. Williams|James A. Foster|Daniel Sellen|Elizabeth Kamau?Mbuthia|Egidioh W. Kamundia|Samwel Mbugua|Sophie E. Moore|Linda J. Kvist|Gloria E. Otoo|Kimberly A. Lackey|Katherine E. Flores|Rossina G. Pareja|Lars Bode|Juan M. Rodríguez
What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings
Universidad Complutense de Madrid|Universidad Complutense de Madrid|Universidad Complutense de Madrid|Universidad Complutense de Madrid|Washington State University|Washington State University|University of Idaho|University of Idaho|University of Idaho|Public Health Ontario|University of Toronto|Egerton University|Egerton University|Egerton University|King's College London|MRC Unit the Gambia|Lund University|University of Ghana|Washington State University|Washington State University|Instituto de Investigación Nutricional|University of California, San Diego|Universidad Complutense de Madrid
human milk provides wide range nutrients bioactive components including immune factors human milk oligosaccharides commensal microbiota factors essential interconnected processes including immunity programming development normal infant gastrointestinal microbiome newborn immune protection mostly relies maternal immune factors provided milk however studies dealing indepth profiling different immune compounds present human milk assessment natural variation healthy women different populations scarce context objective work detection quantification wide array immune compounds including innate immunity factors il1 il6 il12 inf tnf acquired immunity factors il2 il4 il10 il13 il17 chemokines il8 gro mcp1 mip1 growth factors il5 il7 epidermal growth factor egf granulocyte colonystimulating factor granulocytemacrophage colonystimulating factor tgf2 immunoglobulins iga igg igm milk produced healthy women different ethnicities living different geographic dietary socioeconomic environmental settings among analyzed factors iga igg igm egf tgf2 il7 il8 gro mip1 detected samples collected population therefore specific set compounds might considered core soluble immune factors milk produced healthy women worldwide approach may help define immune factors common milk produced women living various conditions identify host lifestyle environmental factors affect immunological composition complex biological fluid clinical trial registration wwwclinicaltrialsgov identifier nct02670278