May A. Beydoun|Gregory A. Dore|Jose A Canas|Hailun Liang|Hind A. Beydoun|Michele K. Evans|Alan B. Zonderman
Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults
National Institute on Aging|National Institutes of Health|National Institute on Aging|National Institutes of Health|Johns Hopkins All Children's Hospital|Johns Hopkins University|Renmin University of China|Johns Hopkins University|Johns Hopkins Medicine|National Institute on Aging|National Institutes of Health|National Institute on Aging|National Institutes of Health
objectivesbackground systemic inflammation affect cognitive performance time current study examined associations systemic inflammation cognitive performance among african americans whites urban adults stratifying sex age group race patientsmethods among 15551719 white africanamerican urban adults agebase 3064y 20042013 meansd followup timey 464 093y conducted linear mixedeffects regression models conducted test associations inflammatory markers creactive protein erythrocyte sedimentation rate esr albumin iron inflammation composite score ics longitudinal cognitive performance results among key findings crp linked poorer baseline mental status among younger women 50y 01 003 001 p 0002 poorer attention older women 50y 01 0024 0007 p 0004 africanamericans 01 0029 0008 p 0001 esr related faster decline verbal memory among older men 50y 11 0008 0003 p 0009 poorer performance attention tests overall 01 0010 0003 p 0003 among africanamericans 01 0013 0004 p 0002 verbal fluency among older women 50y01 0037 0013 p 0004 executive function overall 01 062 021 p 0004 older men 50y 01 169 053 p 0001 africanamericans 01 084 028 p 0002 albumin linked slower attention decline among older men 50y 11 0329 0103 p 0009 overtime improvement executive function overall 11 600 226 p 0008 better baseline psychomotor speed among africanamericans 01 056 019 p 0003 finally ics predicted faster decline visual memoryvisuoconstructive abilities among older men 50y 11 017 006 p 0003 conclusion sum strong associations systemic inflammation longitudinal cognitive performance detected largely among older individuals 50y africanamericans randomized trials targeting inflammation warranted