Yeasir Karim|Abu Eabrahim Siddique|Faruk Hossen|Mizanur Rahman|Victor Mondal|Hasan Ul Banna|M.M. Hasibuzzaman|Zubaer Hosen|Md. Kamrul Islam|Md. Khalequzzaman Sarker|Farjana Nikkon|Zahangir Alam Saud|Xin Lian|Seiichiro Himeno|Khaled Hossain
Dose-dependent relationships between chronic arsenic exposure and cognitive impairment and serum brain-derived neurotrophic factor
University of Rajshahi|University of Rajshahi|University of Rajshahi|University of Rajshahi|University of Rajshahi|University of Rajshahi|University of Rajshahi|Islamic University|Islamic University|Rajshahi Medical College|University of Rajshahi|University of Rajshahi|Tokushima Bunri University|Tokushima Bunri University|University of Rajshahi
arsenic poisoning public health problem worldwide studies reported effects arsenic exposure adult cognitive function limitations subject selection exposure markers moreover information regarding association arsenic exposure biomarker cognitive impairment scarcewe examined associations arsenic exposure adult cognitive impairment using minimental state examination mmse serum levels brainderived neurotrophic factor bdnf potential biomarker cognitive health statuswe designed crosssectional study recruited 693 adult 1860 years old subjects areas low higharsenic exposure rural bangladesh subjects arsenic exposure levels drinking water hair nail arsenic concentrations measured inductively coupled plasmamass spectroscopy bangla version mmse used cognitive assessment tool serum bdnf sbdnf levels assessed immunoassayin study found average mmse score sbdnf level subjects arsenicendemic areas significantly p 0001 lower subjects nonendemic area analyses revealed mmse scores sbdnf levels decreased increasing concentrations arsenic drinking water hair nails dosedependent fashion regression analyses significant associations arsenic exposure metrics mmse scores sbdnf levels observed even adjustment several variables intriguingly mmse scores showed significantly positive correlation sbdnf levelsour findings demonstrate chronic exposure arsenic dosedependently decreases cognitive function adults concomitant reduction sbdnf levels decreased bdnf level may part biochemical basis chronic arsenic exposurerelated cognitive impairment