Enrica Menditto|Caitriona Cahir|Mercedes Aza?Pascual?Salcedo|Dario Bruzzese|Beatriz Poblador?Plou|Sara Malo|El??sio Costa|Francisca González?Rubio|Antonio Gimeno-Miguel|Valentina Orlando|Przemys?aw Kardas|Alexandra Prados?Torres
Adherence to chronic medication in older populations: application of a common protocol among three European cohorts
University of Naples Federico II|Royal College of Surgeons in Ireland|Instituto de Investigación Sanitaria Aragón|Instituto de Salud Carlos III|Servicio Aragonés de Salud|Federico II University Hospital|Instituto de Investigación Sanitaria Aragón|Instituto de Salud Carlos III|Universidad de Zaragoza|Universidade do Porto|Universidad de Zaragoza|Instituto de Investigación Sanitaria Aragón|Instituto de Salud Carlos III|Servicio Aragonés de Salud|Instituto de Investigación Sanitaria Aragón|Instituto de Salud Carlos III|University of Naples Federico II|Medical University of Lodz|Instituto de Investigación Sanitaria Aragón|Instituto de Salud Carlos III
purpose purpose study evaluate compare medication adherence chronic therapies older populations across different regions europe methods explorative study applied harmonized method data extraction analysis pharmacy claims databases three european countries compare medication adherence crosscountry level data obtained period january 1 2010 december 31 2011 patients aged 65 years newly initiated oral antidiabetics antihyperlipidemics antiosteoporotics identified followed 12month period main outcome measures medication adherence medication possession ratio mpr implementation persistence index treatment countryspecific data sets prepared employing common data input model outcome measures calculated country pooled using random effect models results total 39186 new users analyzed pooled data three countries suboptimal implementation mpr 80 5245 95 ci 33437079 antihyperlipidemics 6135 95 ci 52836922 antiosteoporotics 3033 95 ci 25533560 oral antidiabetics similarly rates nonpersistence discontinuation 5563 95 ci 35247429 antihyperlipidemics 6024 95 ci 45357346 antiosteoporotics 4680 95 ci 3640574 oral antidiabetics conclusion medication adherence suboptimal 50 older people nonadherent antihyperlipidemics antiosteoporotics three european cohorts however degree variability adherence rates among three countries high harmonized method data extraction analysis across healthrelated database europe useful compare medicationtaking behavior crosscountry level keywords drug utilization medication adherence medication persistence prescribing