Babak Mokhlesi|Sandra A. Ham|David Gozal
The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database
University of Chicago|University of Chicago|University of Chicago
obstructive sleep apnoea osa highly prevalent condition studies exploring burden osaassociated comorbidities limited small sample sizes underrepresentation womenwe queried truven health marketscan research databases 20032012 collection health insurance claims working adults retirees employersponsored health insurance adults diagnostic code osa least 12 months followup index date osa diagnosis compared matched random sample comorbidities assessed using international classification diseases ninth edition codes logistic regression model constructed test independent association osa comorbiditiesour cohort included 1704905 patients osa 1704417 matched controls comorbidities significantly prevalent osa patients type 2 diabetes ischaemic heart disease prevalent men hypertension depression prevalent women osa contrast sex differences prevalence congestive heart failure arrhythmias stroke less pronounced prevalence comorbidities increased age effect age varied based specific comorbidity divergence osa controls pronounced sixth decade life cardiovascular diseases ieheart failure ischaemic heart disease stroke arrhythmias depression exhibited opposite trend fully adjusted model odds comorbidities significantly increased osa patientsin large nationally representative sample working retired people osa strongly associated significant comorbidities men women unique sex differences emerging