Ji-Heh Park|Eun-Kyoung Park|Dong-Wan Koo|Shinwon Lee|Sunhee Lee|Geun-Tae Kim|Seung?Geun Lee
Compliance and persistence with oral bisphosphonates for the treatment of osteoporosis in female patients with rheumatoid arthritis
Pusan National University Hospital|Pusan National University Hospital|Dong-Eui University|Pusan National University Hospital|Pusan National University Hospital|Kosin University|Pusan National University Hospital
poor adherence oral bisphosphonates bps mitigate therapeutic benefit osteoporosis significant clinical burden previous studies regarding adherence oral bps focused postmenopausal osteoporosis little attention given patients rheumatoid arthritis ra thus investigated compliance persistence oral bps treatment osteoporosis analyzed risk factors poor adherence female patients ra real settingthis retrospective longitudinal study including 396 female patients ra oral bps newly initiated aug 2004 aug 2014 university rheumatology center south korea compliance quantified using 1year medication possession ratio mpr persistence defined duration initiation end bps therapy without interruption exceeding 56 days seropositve ra defined positive test result presence either rheumatoid factor anticyclic citrullinated peptide antibodyof 396 ra patients 221 558 prescribed risedronate 35 mg weekly 17 43 received alendronate 70 mg weekly 158 399 received ibandronate 150 mg monthly 1year mpr 701 proportion ra patients 1year mpr 08 601 total 274 692 patients discontinued oral bps study period persistence bps 633 1 year 507 2 years 333 3 years common cause nonpersistence adverse events 475 followed poor health literacy 405 cost 12 compliance persistence monthly oral bps significantly lower weekly regimens 248 95 ci 159389 p 0001 hr 219 95 ci 169283 p 0001 respectively additionally patients seropositive ra showed better compliance persistence bps compared seronegative counterpartscompliance persistence oral bps ra patients suboptimal real practice thereby limiting efficacy osteoporosis treatment extending dosing interval bps may improve medication adherence ra patients