Weiguang Xie, Jingyi Xiao, Jingyi Chen, Hanzhong Huang, Xuehua Huang, Shaoyi He, Lin Xu
Impact of health education on promoting influenza vaccination health literacy in primary school students: a cluster randomised controlled trial protocol
BMJ open
chlamydia pneumoniae c pneumoniae implicated pathogenesis alzheimers disease ad chlamydial elementary reticulate bodies identified tissues afflicted ad brain regions electron immunoelectron microscopy whereas similar tests nonad brains negative bacterium studies mice shown c pneumoniae rapidly penetrate central nervous system entering glia causing beta amyloid deposition via nerves nasal cavity brain serve invasion pathways used data uk biobank ukbb assess relationship chlamydia ad circulating c pneumoniae antigen measurements available ukbb data field 23037 held measurements porb antigen chlamydia trachomatis c trachomatis used c trachomatis surrogate c pneumoniae since serum crossreactivity c trachomatis c pneumoniae antigens occurs patients documented infection healthy children revealed microimmunofluorescence immunoblotting techniques single nucleotide polymorphism snp data rs429358 rs7412 used impute apoe genotypes porb antigen levels c trachomatis significantly higher subjects ad p0007 porb antigen levels related apoe genotype e3e3 e3e4 e4e4 p0783 control effects age sex educational level apoe genotype logistic regression analysis performed ad dependent variable independent variables sqrt porb antigen c trachomatis age sex educational level apoe genotype ad odds ratio increased 1156 unit increase sqrt porb antigen c trachomatis effect significant p0004 porb antigens c trachomatis significantly higher subjects ad corroborates previous studies demonstrating c pneumoniae inflammation appears play role ad development ad may result reactivation embryologic processes pathways silenced birth trigger reactivation may bacterial viral infections studies warranted