Leila Razeghian Jahromi, Mohammad Ali Tlais, Hassan Kamar, Alireza Jalali
Comparison of Theory of Mind between Patients with Major Depressive Disorder and Stimulant-Induced Depressive Disorder
Iranian journal of psychiatry
differential methylation dm actively recruited different types fundamental translational studies currently microarray ngsbased approaches methylation analysis widely used multiple statistical models designed extract differential methylation signatures benchmarking dm models challenging due absence gold standard data study analyze extensive number publicly available ngs microarray datasets divergent widely utilized statistical models apply recently suggested validated rankstatisticbased approach hobotnica evaluate quality results overall microarraybased methods demonstrate robust convergent results ngsbased models highly dissimilar tests simulated ngs data tend overestimate quality dm methods therefore recommended use caution evaluation top 10 dmc top 100 dmc addition notsubset signature also shows stable results microarray data summing given observed heterogeneity ngs methylation data evaluation newly generated methylation signatures crucial step dm analysis hobotnica metric coordinated previously developed quality metrics provides robust sensitive informative estimation methods performance dm signatures quality absence gold standard data solving longexisting problem dm analysis