David T. Eton|Roger T. Anderson|Wendy F. Cohn|Erin M. Kennedy|Jennifer L. St. Sauver|Bayly Bucknell|Kathryn J. Ruddy
&lt;p&gt;Risk factors for poor health-related quality of life in cancer survivors with multiple chronic conditions: exploring the role of treatment burden as a mediator&lt;/p&gt;
Mayo Clinic in Florida|University of Virginia|University of Virginia|University of Virginia|Mayo Clinic in Florida|Mayo Clinic in Arizona
purpose study identify risk factors poor healthrelated quality life hrql multimorbid adult cancer survivors explore whether perceived treatment selfmanagement burden mediate relationshipsninetyone multimorbid cancer survivors median age 65 years completed surveys baseline 6 months demographic psychosocial health carerelated factors assessed perceived treatment burden general hrql physical mental health data medical diagnoses cancer treatment extracted medical record bivariate correlations screened associations predictors outcomes significant predictors entered multivariable linear regressions identify unique risk factors greater treatment burden poorer hrql followup regressions examined whether treatment burden mediated risk factoroutcome relationshipsfactors correlated higher baseline treatment burden included diagnoses less formal education seen physicians past 6 months mental health diagnosis set routine ones selfmanagement low health literacy low selfefficacy selfmanagement low social support ps 005 among factors also correlated worse 6month hrql outcome included diagnoses seen physicians past 6 months mental health diagnosis set routine ones selfmanagement low health literacy low selfefficacy low social support ps 005 multivariable regressions showed factors independently predicted higher treatment burden andor worse hrql low selfefficacy robust independent risk factor poor hrql bs 034049 ps 0005 evidence supporting relationships partially mediated treatment burdenmonitoring psychosocial health carerelated risk factors high treatment burden poor hrql identify multimorbid cancer survivors need extra support could inform personalized treatment approach