Fiffi Boman, Martin Stafström, Nils Lundin, Mahnaz Moghadassi, Carl-Johan Törnhage, Per-Olof Östergren
Comparing parent and teacher assessments of mental health in elementary school children
Scandinavian journal of public health
understand cellular processes biochemical pathways signaling networks need understand binding reaction rates often competing reactions dependence cellular concentrations participating molecules regulation rates allostery posttranslational modifications mechanisms break systems elementary steps almost invariably either unimolecular bimolecular reactions frequently occur subsecond often submillisecond time scales rapid mixing techniques generally achieve mixing less 2 ms generally suitable study reactions application techniques study enzyme mechanisms described several excellent texts cornishbowden fundamentals enzyme kinetics 1995 gutfreund kinetics life sciences receptors transmitters catalysis 1995 flow techniques used study individual steps monitoring approach equilibrium presteady state single turnover conditionsthe individual steps complex biochemical reaction schemes determine fast systems respond incoming signals adapt changed conditions 1 2 chapter concerned vitro techniques developed study fast reactions solution present study various interactions calmodulin example kinetic information obtained techniques indispensable understanding dynamics biochemical processes complements static structural thermodynamic information available xray crystallography nmr equilibrium binding studies