Carmen Ricardo-Barreto, Marco Cervantes, Jorge Valencia, John Cano-Barrios, Jorge Mizuno-Haydar
Colombian Elders and Their Use of Handheld Digital Devices
Frontiers in psychology
effects indolehallucinogen psilocybin mixed 5ht2 5ht1 agonist regional cerebral glucose metabolism investigated 10 healthy volunteers pet f18fluorodeoxyglucose fdg prior following 15 20mg dose psilocybin psychotomimetic doses psilocybin found produce global increase cerebral metabolic rate glucose cmrglu significant marked increases frontomedial frontolateral cortex 243 anterior cingulate 249 temporomedial cortex 253 somewhat smaller increases cmrglu found basal ganglia 185 smallest increases found sensorimotor 147 occipital cortex 144 increases cmrglu prefrontal cortex anterior cingulate temporomedial cortex putamen correlated positively psychotic symptom formation particular hallucinatory ego disintegration present data suggest excessive 5ht2 receptor activation results hyperfrontal metablic pattern parallels comparable metabolic findings associated acute psychotic episodes chronic schizophrenics contrasts hypofrontality chronic schizophrenic patients