Meram Azzani, Gogilawani A P Muagan, Wahib M Atroosh, Ian Zhen Ng
Risk of cardiovascular diseases among young adults: a cross-sectional study in Malaysia
BMJ open
background modification diet renal disease mdrd study equation underestimates measured glomerular filtration rate gfr levels 60 mlmin173 m2 variable accuracy among subgroups consequently estimated gfr egfr 60 mlmin173 m2 reported clinical laboratories performance accurate gfrestimating equation chronic kidney disease epidemiology collaboration ckdepi equation reported level gfr clinical characteristics study design test diagnostic accuracy setting participants pooled data set 3896 people 16 studies measured gfr used development either equation subgroups defined egfr age sex race diabetes prior solidorgan transplant body mass index index tests egfr ckdepi mdrd study equations standardized serum creatinine reference test measured gfr using urinary plasma clearance exogenous filtration markers results mean measured gfr 68 36 sd mlmin173 m2 egfr 30 mlmin173 m2 equations similar bias median difference compared measured gfr egfr 3059 mlmin173 m2 bias decreased 49 21 mlmin173 m2 57 improvement egfr 6089 mlmin173 m2 bias decreased 119 42 mlmin173 m2 61 improvement egfr 90119 mlmin173 m2 bias decreased 100 19 mlmin173 m2 75 improvement similar improved performance noted subgroups egfr 90 mlmin173 m2 body mass index 20 kgm2 greater variation noted subgroups egfr 90 mlmin173 m2 limitations limited number elderly people racial ethnic minorities measured gfr conclusions ckdepi equation accurate mdrd study equation overall across subgroups contrast mdrd study equation egfr 60 mlmin173 m2 reported using ckdepi equation modification diet renal disease mdrd study equation underestimates measured glomerular filtration rate gfr levels 60 mlmin173 m2 variable accuracy among subgroups consequently estimated gfr egfr 60 mlmin173 m2 reported clinical laboratories performance accurate gfrestimating equation chronic kidney disease epidemiology collaboration ckdepi equation reported level gfr clinical characteristics test diagnostic accuracy pooled data set 3896 people 16 studies measured gfr used development either equation subgroups defined egfr age sex race diabetes prior solidorgan transplant body mass index egfr ckdepi mdrd study equations standardized serum creatinine measured gfr using urinary plasma clearance exogenous filtration markers mean measured gfr 68 36 sd mlmin173 m2 egfr 30 mlmin173 m2 equations similar bias median difference compared measured gfr egfr 3059 mlmin173 m2 bias decreased 49 21 mlmin173 m2 57 improvement egfr 6089 mlmin173 m2 bias decreased 119 42 mlmin173 m2 61 improvement egfr 90119 mlmin173 m2 bias decreased 100 19 mlmin173 m2 75 improvement similar improved performance noted subgroups egfr 90 mlmin173 m2 body mass index 20 kgm2 greater variation noted subgroups egfr 90 mlmin173 m2 limited number elderly people racial ethnic minorities measured gfr ckdepi equation accurate mdrd study equation overall across subgroups contrast mdrd study equation egfr 60 mlmin173 m2 reported using ckdepi equation