Benjamin C Ingman, Carla Loecke, Elaine S Belansky
A Partnership Among Local Public Health Agencies, Elementary Schools, and a University to Address Childhood Obesity: A Scalable Model of the Assess, Identify, Make It Happen Process
Frontiers in health services
question whether childrens exposure trafficrelated air pollution trap contributes development asthma unresolved conducted systematic review performed metaanalyses analyze association trap asthma development childhoodwe systematically reviewed epidemiological studies published 8 september 2016 available embase ovid medline r transport databaseswe included studies examined association childrens exposure trap metrics risk asthma incidence lifetime prevalence birth age 18years oldwe extracted key characteristics included study using predefined data items template tabulated used critical appraisal skills programme checklists assess validity included study four independent risk estimates available continuous pollutant exposure conducted overall agespecific metaanalyses four sensitivity analyses summary metaanalytic exposureoutcome associationfortyone studies met eligibility criteria notable variability asthma definitions trap exposure assessment methods confounder adjustment overall randomeffects risk estimates 95 ci 108 103 114 per 05105m1 black carbon bc 105 102 107 per 4gm3 nitrogen dioxide no2 148 089 245 per 30gm3 nitrogen oxides nox 103 101 105 per 1gm3 particulate matter 25m diameter pm25 105 102 108 per 2gm3 particulate matter 10m diameter pm10 sensitivity analyses supported findings across main analysis agespecific analysis least heterogeneity seen bc estimates heterogeneity pm25 pm10 estimates heterogeneity no2 nox estimatesthe overall risk estimates metaanalyses showed statistically significant associations bc no2 pm25 pm10 exposures risk asthma development findings support hypothesis childhood exposure trap contributes development asthma future metaanalyses would benefit greater standardization study methods including exposure assessment harmonization outcome harmonization confounders harmonization inclusion important confounders individual studiesprospero 2014 crd42014015448