Dana Hashim|Samantha Sartori|Paul Brennan|María Paula Curado|Victor Wünsch-Filho|Kimon Divaris|Andrew F. Olshan|José P. Zevallos|Deborah M. Winn|Silvia Franceschi|Xavier Castellsagué|Jolanta Lissowska|Péter Rudnai|Keitaro Matsuo|Hal Morgenstern|Chen X. Chen|Thomas L. Vaughan|Jonathan N. Hofmann|Gypsyamber D’Souza|Robert I. Haddad|Huadong Wu|Y. C. Lee|Mia Hashibe|Carlo La Vecchia|Paolo Boffetta
The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium
Icahn School of Medicine at Mount Sinai|Icahn School of Medicine at Mount Sinai|International Agency For Research On Cancer|Universidade de São Paulo|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|National Cancer Institute|International Agency For Research On Cancer|Institut d'Investigació Biomédica de Bellvitge|Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública|Institut Català d'Oncologia|The Maria Sklodowska-Curie National Research Institute of Oncology|National Public Health and Medical Officer Service|Aichi Cancer Center|University of Michigan–Ann Arbor|Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa|Fred Hutch Cancer Center|Cancer Research Center|Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa|Fred Hutch Cancer Center|Cancer Research Center|Cancer Institute (WIA)|Johns Hopkins University|Harvard University|Dana-Farber Cancer Institute|Icahn School of Medicine at Mount Sinai|Huntsman Cancer Institute|University of Utah|Huntsman Cancer Institute|University of Utah|University of Milan|Tisch Hospital|Icahn School of Medicine at Mount Sinai
backgroundpoor oral hygiene proposed contribute head neck cancer hnc risk although causality independency indicators uncertain study investigates relationship five oral hygiene indicators incident hncsmethodsin pooled analysis 8925 hnc cases 12 527 controls 13 studies participating international head neck cancer epidemiology consortium comparable data good oral hygiene indicators harmonized included denture wear gum disease bleeding 5 missing teeth tooth brushing least daily visiting dentist year logistic regression used estimate effects oral hygiene indicator cumulative score hnc risk adjusting tobacco smoking alcohol consumptionresultsinverse associations hnc hypothesized direction observed 5 missing teeth odds ratio 078 95 confidence interval ci 074 082 annual dentist visit 082 95 ci 078 087 daily tooth brushing 083 95 ci 079 088 gum disease 094 95 ci 089 099 association observed wearing dentures associations relatively consistent across specific cancer sites especially tooth brushing dentist visits population attributable fraction 2 5 good oral hygiene indicators 89 95 ci 33 14 oral cavity cancerconclusiongood oral hygiene characterized missing teeth annual dentist visits daily tooth brushing may modestly reduce risk hnc