Rollin Wright|Yazan F. Roumani|Robert Boudreau|Anne B. Newman|Christine M. Ruby|Stephanie A. Studenski|Ronald I. Shorr|Douglas C. Bauer|Eleanor M. Simonsick|Sarah N. Hilmer|Joseph T. Hanlon
Effect of Central Nervous System Medication Use on Decline in Cognition in Community?Dwelling Older Adults: Findings from the Health, Aging and Body Composition Study
University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|University of Pittsburgh|University of California, San Francisco|National Institutes of Health|University of Sydney|University of Pittsburgh
objectives evaluate whether combined use multiple central nervous system cns medications time associated cognitive change design longitudinal cohort study setting pittsburgh pennsylvania memphis tennessee participants two thousand seven hundred thirtyseven healthy adults aged 65 enrolled health aging body composition study without baseline cognitive impairment modified minimental state examination 3ms score 80 measurements cns medication benzodiazepine opioidreceptor agonists antipsychotics antidepressants use duration dose determined baseline year 1 years 3 5 cognitive function measured using 3ms baseline years 3 5 outcome variables incident cognitive impairment 3ms score lt80 cognitive decline 5point decline 3ms multivariable intervalcensored survival analyses conducted results year 5 77 subjects incident cognitive impairment 252 demonstrated cognitive decline cns medication use increased 139 baseline 153 171 years 3 5 respectively associated incident cognitive impairment adjusted hazard ratio adj hr111 95 confidence interval ci073169 associated cognitive decline adj hr 137 95 ci111170 longer duration adj hr139 ci108179 higher doses gt3 standardized daily doses adj hr187 95 ci125279 cns medications suggested greater risk cognitive decline nonuse conclusion combined use cns medications especially higher doses appears associated cognitive decline older adults future studies must explore effect combined cns medication use vulnerable older adults