Sabah Jaroof, Johann Cailhol
Design of a bilingual (FR-UR) website on the sensitive topic of sexual and mental health with Urdu speakers in a Parisian suburb: a qualitative study
BMC public health
alzheimers disease ad multifactorial neurodegenerative disease complex origin thought involve combination genetic biological environmental factors insulin dysfunction emerged potential factor contributing ad pathogenesis particularly individuals diabetes among insulin deficiency undergoing insulin therapy intraperitoneal administration streptozotocin stz widely used rodent models explore impact insulin deficiency ad pathology although prior research predominantly focused young animals comparative analysis across different age groups study aimed fill gap analyzing impact insulin dysfunction 7 23 months 3xtgad mice exhibit amyloid tau pathologies objective elucidate agespecific consequences insulin deficiency ad pathology stz administration led insulin deficiency younger mice resulting increase cortical amyloid tau aggregation tau phosphorylation significantly affected conversely older mice displayed unexpected resilience peripheral metabolic impact stz exhibiting increase tau phosphorylation aggregation without significantly affecting amyloid pathology changes paralleled alterations signaling pathways involving tau kinases phosphatases several markers bloodbrain barrier bbb integrity declined age 3xtgad mice might facilitated direct neurotoxic effect stz older mice overall research confirms influence insulin signaling dysfunction ad pathology also advises careful interpretation data related stzinduced effects older animals