Geraldine Moreno-Black, Jean Stockard
Two Worlds of Obesity: Ethnic Differences in Child Overweight/Obesity Prevalence and Trajectories
Journal of racial and ethnic health disparities
previously shown polygenic risk scores prs improve risk stratification peripheral artery disease pad large retrospective cohort evaluate potential prs improving detection pad prediction major adverse cardiovascular cerebrovascular events macce adverse events ae institutional patient cohort created cohort 278 patients 52 cases 226 controls fit padspecific prs based weighted sum risk alleles built traditional clinical risk models machine learning ml models using clinical genetic variables detect pad macce ae models performances measured using area curve auc net reclassification index nri integrated discrimination improvement idi brier score also evaluated clinical utility pad model using decision curve analysis dca found modest statistically significant improvement pad detection models performance inclusion prs 0902 95 ci 08460957 clinical variables 0909 95 ci 08560961 clinical variables prs prs inclusion significantly improved risk reclassification pad nri 007 95 ci 00020137 p 004 ml model predicting macce addition prs significantly improve auc however nri analysis demonstrated significant improvement risk reclassification p 2e05 decision curve analysis showed higher net benefit combined prsclinical model across thresholds pad detection including prs clinical padrisk model associated improvement risk stratification clinical utility although see significant change auc result underscores potential clinical utility incorporating prs data clinical risk models prevalent pad need use evaluation metrics discern clinical impact using new biomarkers smaller populations