Takeshi Fujiwara, Kaori Kikuchi, Satoshi Hoshide, Takuya Tsuchihashi, Kazuomi Kario
Usefulness of a salt check sheet for elementary school and junior high school children
Journal of clinical hypertension (Greenwich, Conn.)
vancomycin used grampositive infections including methicillinresistant staphylococcus aureus 2020 vancomycin guidelines described j rybak j le p lodise p levine et al j health syst pharm 77835864 2020 httpsdoiorg101093ajhpzxaa036 provided update vancomycin dosing recommended optimal area concentrationtime curve 24 h mic aucmic target 400 600 2021 pharmacydriven aucmic vancomycin dosing protocol implemented across 12 sentara health system hospitals primary objective study assess pharmacydriven aucmic vancomycin dosing protocol led fewer acute kidney injury aki events troughbased dosing secondary objectives included vancomycin duration hospital length stay administered vancomycin dose admission vancomycin labs drawn standard lab times cost aki assessed two separate ways modified akin acute kidney injury network criteria ii modified version vancomycin guidelines inferential statistics used analyze results retrospective study per akin definition rates aki 139 3492507 troughbased group 149 3692471 aucmicbased group p 0309 per definition vancomycin guidelines rates aki 67 1692507 troughbased group 76 1872471 aucmicbased group p 0258 total 52 26795151 vancomycin labs obtained standard lab times auc group 24 11444766 trough group p 005 difference aki events auc trough dosing use contrast dye may confound results aucmic dosing associated lab draws standard times larger number labs drawn per person less total use vancomycin importance article report differences rates acute kidney injury troughbased vancomycin dosing aucmicbased vancomycin dosing across 12 hospitals aucmic dosing resulted vancomycin lab draws standard lab draw times compared trough dosing thus making convenient health care personnel study includes uses vancomycin including empirical use patient severity levels therefore research reflects realworld use vancomycin hospitals aucmic dosing supported various infectious disease societies however feasibility incorporating aucmic dosing hospitals undetermined study unique includes hospitals various sizes small community hospitals academic teaching hospital includes feasibility component therefore study broad applicability hospitals across united states original research includes clinical application vancomycin multicenter health system