A Hartmann, S Ansquer, C Brefel-Courbon, P Burbaud, A Castrioto, V Czernecki, P Damier, E Deniau, S Drapier, I Jalenques, O Marechal, T Priou, M Spodenkiewicz, S Thobois, A Roubertie, T Witjas, M Anheim
French guidelines for the diagnosis and management of Tourette syndrome
Revue neurologique
databased predictions individual cognitive behavioral therapy cbt treatment response fundamental step towards precision medicine past studies demonstrated moderate prediction accuracy ie ability discriminate responders nonresponders given treatment using clinical routine data demographic questionnaire data neuroimaging data achieved superior prediction accuracy however studies may considerably biased due limited sample sizes biasprone methodology adequately powered crossvalidated samples prerequisite evaluate predictive performance identify promising predictors therefore analyzed resting state functional magnet resonance imaging rsfmri data two large clinical trials test whether functional neuroimaging data continues provide good prediction accuracy much larger samples data came two distinct german multicenter studies exposurebased cbt anxiety disorders protectad spidervr studies separately independently preprocessed baseline rsfmri data n 220 patients protectad n 190 patients spidervr extracted variety features including roitoroi edgefunctional connectivity slidingwindows graph measures including features sophisticated machine learning pipelines found predictions individual outcomes never significantly differed chance level even conducting range exploratory posthoc analyses moreover resting state data never provided prediction accuracy beyond sociodemographic clinical data analyses independent terms selecting methods process resting state data prediction input well used parameters machine learning pipelines corroborating external validity results similar findings two independent studies analyzed separately urge caution regarding interpretation promising prediction results based neuroimaging data small samples emphasizes prediction accuracies previous studies may result overestimation due homogeneous data weak crossvalidation schemes promise restingstate neuroimaging data play important role prediction cbt treatment outcomes patients anxiety disorders remains yet delivered