Benjamin Karer, Hans Hagen, Dirk J Lehmann
Insight Beyond Numbers: The Impact of Qualitative Factors on Visual Data Analysis
IEEE transactions on visualization and computer graphics
integrated testing strategies itss considered tools guiding resource efficient decisionmaking chemical hazard risk management originating midnineties research initiatives minimizing animal use toxicity testing development still lacks methodologically consistent framework incorporating relevant information updating reducing uncertainty across testing stages handling conditionally dependent evidence paper presents conceptual methodological proposal improving development discuss methodological shortcomings current approaches identify conceptual requirements development optimization first development based probabilistic methods order quantify update various uncertainties across testing stages second reasoning reflect set logic rules consistently combining probabilities related events third inference hypothesisdriven reflect causal relationships order coherently guide decisionmaking across testing stages meet requirements propose informationtheoretic approach development inference framework made operational using bayesian networks illustration examine simple twotest battery assessing rodent carcinogenicity finally demonstrate running bayesian network reveals quantitative measure weightofevidence