Danielle M. McCarthy|Terry C. Davis|Jennifer P. King|Rebecca Mullen|Stacy Cooper Bailey|Marina Serper|Kara L. Jacobson|Ruth M. Parker|Michael S. Wolf
Take-Wait-stop: A Patient-Centered Strategy for Writing PRN Medication Instructions
Northwestern University|Louisiana State University Health Sciences Center Shreveport|Northwestern University|Northwestern University|University of North Carolina at Chapel Hill|Northwestern University|Emory University|Emory University|Northwestern University
recent studies linked patient misunderstanding label instructions needed prn medications dosing errors study conducted preliminary field test patientcentered prn label instructions patients participated hypothetical dosing experiment randomized patientcentered label referred takewaitstop standard label participants asked demonstrate dosing medicine 24 hours three types independent dosing errors measured taking two pills one time b exceeding maximum daily dose c waiting fewer 4 hours doses generalized linear models used assess association label type health literacy sociodemographic characteristics participants mean age 398 years 621 female 437 white 724 adequate literacy participants 318 shown standard label demonstrated taking excess 6 pills 24 hours compared 140 participants shown takewaitstop label p 05 overall 1 person demonstrated would take 2 pills single dose standard label group 205 demonstrated dosing intervals fewer 4 hours compared 233 takewaitstop label group p75 multivariate model participants exposed standard label 25 times likely exceed recommended maximum daily dose 95 ci 105 770 p03 takewaitstop label beneficial preventing participants exceeding maximum dose 24 hours although significantly reduce dosing errors