Haribalakrishna Balasubramanian, Javed Ahmed, Anitha Ananthan, Lakshmi Srinivasan, Diwakar Mohan
Comparison of parent or caregiver-completed development screening tools with Bayley Scales of Infant Development: a systematic review and meta-analysis
Archives of disease in childhood
estrogen receptorlow erlow her2negative breast cancer similar pathological molecular characteristics triplenegative breast cancer tnbc questionable whether considered separate entity international guidelines lowered cutoff er positivity 1 2010 10 threshold kept sweden erlow breast cancer er 19 thus sweden treated tnbc aimed describe patient tumor characteristics treatment patterns overall survival swedish populationbased cohort patients erzero erlow her2negative breast cancer treated tnbc tnbc cases diagnosed sweden 20082020 included populationbased cohort study patient tumor treatment characteristics analyzed erstatus er 0 vs 19 associations subgroups compared using 2 test survival endpoint overall survival os kaplanmeier curves estimated cox proportional hazards models used estimate adjusted hazard ratios comparing erlow erzero 5655 tumors 901 er expression 0 99 erlow erlow tumors grade iii 694 808 erzero tumors pvalue 0001 median ki67 60 63 erzero tumors pvalue 0005 significant differences given chemotherapy p 0546 pathological complete response pcr achieved 281 erlow tumors 251 erzero tumors unadjusted analysis os women erlow disease borderline significantly better os erzero disease hr 084 95 ci 071100 p 0052 erstatus 19 vs 0 associated os multivariable analysis hr 111 090136 distant diseasefree survival differ erstatus 0 vs 19 hr 097 erzero vs erlow 062153 p 0905 preoperative treatment impact pcr os significantly differ erzero erlow disease erlow her2negative breast cancer characteristics prognosis similar tnbc treated way therefore seems reasonable use 10 threshold er positivity would provide patients erlow tumors treatment opportunities patients tnbc within studies within clinical routine work financially supported merck sharp dohme llc subsidiary merck co inc rahway nj usa accordance terms conditions master collaboration agreement company karolinska institutet