John Chee Meng Wong, Joelle Yan Xin Chua, Pao Yi Chan, Shefaly Shorey
Effectiveness of educational interventions in reducing the stigma of healthcare professionals and healthcare students towards mental illness: A systematic review and meta-analysis
Journal of advanced nursing
bioengineering strategies fabrication implantable lymphoid structures mimicking lymph nodes lns tertiary lymphoid structures tls could amplify adaptive immune response therapeutic applications cancer immunotherapy method date resulted consistent formation high endothelial venules hevs specialized vasculature responsible nave cell recruitment education lns tls orthogonal induced differentiation human pluripotent stem cells carrying regulatable etv2 allele used rapidly efficiently induce endothelial differentiation assembly embryoid bodies combining primitive inducible endothelial cells primary human ln fibroblastic reticular cells results formation hevlike structures aggregate 3d organoids hevos upon transplantation immunodeficient mice hevos successfully engraft form lymphatic structures recruit antigenpresenting cells adoptivelytransferred lymphocytes therefore displaying basic tls capabilities results show functionally hevos organize immune response promote antitumor activity adoptivelytransferred lymphocytes collectively experimental approaches represent innovative scalable proofofconcept strategy fabrication bioengineered tls deployed vivo enhance adaptive immune responses