Sasha A Fleary
The Relationship Between a Healthy People 2030 Health Literacy-Related Objective (HC/HIT02) and Cancer Prevention and Screening Behaviors
Health communication
angelman syndrome severe neurodevelopmental disorder caused loss function maternally inherited ube3a gene neurons promising diseasemodifying treatments reinstate ube3a expression development early measure treatment response critical deployment clinical trials increased delta power eeg recordings reflecting abnormal neuronal synchrony occurs across species correlates genotype whether delta power provides reliable biomarker clinical symptoms remains unknown analyzed combined eeg recordings developmental assessments large cohort individuals n 82 subjects 133 combined eeg cognitive assessments 1082816 years 32f evaluated delta power biomarker cognitive function measured bayley cognitive score examined robustness biomarker varying states consciousness recording techniques analysis procedures delta power predicted bayley scale cognitive score p 105 r2 09374 controlling age p 1024 genotypeage p 1011 repeat assessments p 108 excellent fit cross validation r2 095 differences model performance across states consciousness bipolar versus average montages aic 2 models using raw data excluding frontal channels outperformed models aic 4 predicted performance expressive p 00209 receptive communication p 103 fine motor skills p 104 delta power simple direct measure neuronal activity reliably correlates cognitive function electrophysiological biomarker offers objective clinically relevant endpoint treatment response emerging clinical trials