Rebekah Bradley|Elisabeth B. Binder|Michael P. Epstein|Yi?Lang Tang|Hemu P. Nair|Wei Liu|Charles F. Gillespie|Tiina Berg|Mark Evces|D. Jeffrey Newport|Zachary N. Stowe|Christine Heim|Charles B. Nemeroff|Ann C. Schwartz|Joseph F. Cubells|Kerry J. Ressler
Influence of Child Abuse on Adult Depression
h3contexth3 genetic inheritance developmental life stress contribute major depressive disorder adults child abuse trauma alter endogenous stress response principally corticotropinreleasing hormone downstream effectors suggesting gene environment interaction locus may important depression h3objectiveh3 examine whether effects child abuse adult depressive symptoms moderated genetic polymorphisms within corticotropinreleasing hormone type 1 receptor icrhr1i gene h3designh3 association study examining gene environment interactions genetic polymorphisms theicrhr1ilocus measures child abuse adult depressive symptoms h3settingh3 general medical clinics large public urban hospital emory university atlanta georgia h3participantsh3 primary participant population 974 african american low socioeconomic status high rates lifetime trauma n 422 supportive independent sample n 199 distinct ethnically 877 caucasian socioeconomically less impoverished h3main outcome measuresh3 beck depression inventory scores history major depressive disorder structured clinical interview foridsmiviaxis disorders h3resultsh3 fifteen singlenucleotide polymorphisms spanning 57 kilobases theicrhr1igene examined found significant gene environment interactions multiple individual singlenucleotide polymorphisms eg rs110402ipi 008 well common haplotype spanning intron 1 ipi lt 001 specificicrhr1ipolymorphisms appeared moderate effect child abuse risk adult depressive symptoms protective effects supported similar findings second independent sample n 199 h3conclusionsh3 data support corticotropinreleasing hormone hypothesis depression suggest gene environment interaction important expression depressive symptoms adults withicrhr1irisk protective alleles history child abuse