Miriam Marco, Antonio López-Quílez, Francisco Sánchez-Sáez, Pablo Escobar-Hernández, María Montagud-Andrés, Marisol Lila, Enrique Gracia
The Spatio-Temporal Distribution of Suicide-related Emergency Calls in a European City: Age and Gender Patterns, and Neighborhood Influences
Psychosocial intervention
objective study investigate whether high levels serum interleukin il6 creactive protein crp alpha1antichymotrypsin act associated loss muscle strength muscle mass sarcopenia older personsthe study included 986 men women longitudinal aging study amsterdam mean age 746 years standard deviation 62grip strength n 986 appendicular muscle mass n 328 using dualenergy xray absorptiometry obtained 1995 1996 repeated 3year followup loss muscle strength defined loss grip strength greater 40 sarcopenia defined loss muscle mass greater 3 approximating lowest 15 study samplemultiple linear logistic regression analyses revealed higher levels il6 associated greater decline muscle strength decreased 321 kg standard error 081 per standard deviation increase logtransformed il6 adjustment confounders including sociodemographic health lifestyle factors high il6 5 pgml high crp 61 mugml associated 2 3fold greater risk losing greater 40 muscle strength persons high levels act 181 normal human pooled plasma 40 less likely experience loss muscle strength tended p 07 smaller decline muscle mass compared lowest quartile act consistent associations il6 crp sarcopenia foundthe findings prospective populationbased study suggest higher levels il6 crp increase risk muscle strength loss whereas higher levels act decrease risk muscle strength loss older men women