Bea Van den Bergh|Marion I. van den Heuvel|Marius Lahti|Marijke Braeken|Susanne R. de Rooij|Sonja Entringer|Dirk Hoyer|Tessa J. Roseboom|Katri Räikkönen|Suzanne King|Matthias Schwab
Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy
KU Leuven|Flemish Government|Wayne State University|University of Helsinki|Hasselt University|University of Amsterdam|University of California, Irvine|Charité - Universitätsmedizin Berlin|Jena University Hospital|University of Amsterdam|University of Helsinki|McGill University|Douglas Mental Health University Institute|Jena University Hospital
accumulating research shows prenatal exposure maternal stress increases risk behavioral mental health problems later life review systematically analyzes available human studies identify harmful stressors vulnerable periods pregnancy specificities outcome biological correlates relation maternal stress offspring outcome effects maternal stress offspring neurodevelopment cognitive development negative affectivity difficult temperament psychiatric disorders shown numerous epidemiological casecontrol studies offspring sexes susceptible prenatal stress effects differ specific vulnerable period gestation prenatal stress effects vary different gestational ages possibly depending developmental stage specific brain areas circuits stress system immune system biological correlates prenatally stressed offspring aberrations neurodevelopment neurocognitive function cerebral processing functional structural brain connectivity involving amygdalae prefrontal cortex changes hypothalamopituitaryadrenal hpaaxis autonomous nervous system