Samar J Melhem, Shereen Nabhani-Gebara, Reem Kayyali
Evaluating online health information utilisation and its psychosocial implications among breast cancer survivors: Qualitative explorations
Health promotion perspectives
amblyopia common visual impairment childhood public health concern extended period optical treatment patching recommended clinical guidelines several countries aim study compare intensive patching regimen without extended optical treatment eot randomised controlled trial eupatch randomised controlled trial conducted 30 hospitals uk greece austria germany switzerland children aged 38 years newly detected untreated amblyopia defined interocular difference 030 logarithm minimum angle resolution logmar best corrected visual acuity bcva due anisometropia strabismus eligible participants randomly assigned 11 via computergenerated sequence either eot group 18 weeks glasses use patching early patching group 3 weeks glasses use patching stratified type severity amblyopia participants initially prescribed intensive patching regimen 10 hday 6 days per week supplemented motivational materials patching period 24 weeks participants parents guardians assessors trial statistician masked treatment allocation primary outcome successful treatment ie 020 logmar interocular difference bcva 12 weeks patching two primary analyses conducted main analysis included participants including dropped excluded provide outcome data week 12 remained study analysis imputed missing data eligible randomly assigned participants assessed adverse events study registered international standard randomised controlled trial number registry isrctn51712593 longer recruiting june 20 2013 march 12 2020 exclusion eight participants found ineligible detailed screening randomly assigned 334 participants 170 eot group 164 early patching group including 188 56 boys 146 44 girls two 1 participants whose sex recorded 317 participants 158 eot group 159 early patching group analysed primary outcome without imputation missing data median followup time 42 weeks iqr 42 eot group vs 27 weeks 27 early patching group 24 14 170 participants eot group ten 6 164 early patching group excluded dropped study mostly due loss followup withdrawal consent ten 6 eot group three 2 early patching group missed 12 week visit remained study higher proportion participants early patching group successful treatment 107 67 159 eot group 86 54 158 13 difference p0019 12 weeks patching serious adverse events related interventions occurred results trial indicate early patching effective eot treatment children amblyopia findings also provide data personalisation amblyopia treatments action medical research nihr clinical research network ulverscroft foundation