Karen Hall, Jason Skues, Debra Kiegaldie
Working effectively with consumers: Perspectives from students, teachers, nurses, and consumers
International journal of mental health nursing
minimalmeasurable residual disease mrd diagnostics using realtime quantitative pcr analysis rearranged immunoglobulin tcell receptor gene rearrangements nowadays implemented treatment protocols patients acute lymphoblastic leukemia within euromrd consortium aim provide comparable highquality mrd diagnostics allowing appropriate riskgroup classification patients interprotocol comparisons end set quality assessment scheme gradually optimized updated last 20 years includes participants around 70 laboratories worldwide describe design analysis quality assessment scheme addition report revised data interpretation guidelines based newly generated data extensive discussions experts main novelty partial redefinition positive quantitative range category two new categories mrd low positive quantitative range mrd uncertain significance quality assessment program revised guidelines ensure reproducible accurate mrd data patients within consortium similar programs guidelines introduced lymphoid diseases eg bcell lymphoma new technological platforms eg digital droplet pcr nextgeneration sequencing patientspecific mrd pcrbased targets eg fusion genes