Corinne Pettigrew|Anja Soldan|Shanshan Li|Yi Lu|Mei?Cheng Wang|Ola A. Selnes|Abhay Moghekar|Richard O’Brien|Marilyn Albert
Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer’s disease
Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University
apoe 4 allele increases risk developing alzheimers disease whereas apoe 2 allele reduces risk examined whether cognitive reserve cr measured index consisting education reading vocabulary modifies associations cr measured baseline 257 cognitively normal individuals mean age 572 years followed 17 years mean followup 92 years cox regression models showed cr apoe 4 independently affected risk progressing normal cognition onset clinical symptoms cr reduced risk 50 4 carriers noncarriers 4 increased risk 150 contrast apoe 2 interacted cr cr protective 2 carriers noncarriers suggests individuals 2 genotype may disproportionately benefit lifetime experiences enhance cognition