Nino Hasanica, Aida Ramic-Catak, Adnan Mujezinovic, Sead Begagic, Kenan Galijasevic, Mirza Oruc
The Effectiveness of Leaflets and Posters as a Health Education Method
Materia socio-medica
common fruit fly idrosophila melanogasteri well studied highly tractable genetic model organism understanding molecular mechanisms human diseases many basic biological physiological neurological properties conserved mammals id melanogasteri nearly 75 human diseasecausing genes believed functional homolog fly discovery process therapeutics traditional approaches employ highthroughput screening small molecules based primarily vitro cell culture enzymatic assays receptor binding assays majority positive hits identified types vitro screens unfortunately found ineffective andor toxic subsequent validation experiments wholeanimal models new tools platforms needed discovery arena overcome limitations incorporation id melanogasteri therapeutic discovery process holds tremendous promise enhanced rate discovery higher quality leads id melanogasteri models human diseases provide several unique features powerful genetics highly conserved disease pathways low comparative costs fly effectively used low highthroughput drug screens well target discovery review basic biology fly discuss models human diseases opportunities therapeutic discovery central nervous system disorders inflammatory disorders cardiovascular disease cancer diabetes also provide information resources interested pursuing fly models human disease well interested using id melanogasteri drug discovery process