Harm Jan van der Horn, Erik B Erhardt, Andrew B Dodd, Upasana Nathaniel, Tracey V Wick, Jessica R McQuaid, Sephira G Ryman, Andrei A Vakhtin, Timothy B Meier, Andrew R Mayer
A cautionary tale on the effects of different covariance structures in linear mixed effects modeling of fMRI data
Human brain mapping
findings effectiveness medication reviews led community pharmacists cps often inconclusive hypothesized studies sufficiently standardized thus difficult draw conclusions examine differences way cpled medication review studies set accomplished investigating 1 patient selection criteria 2 components medication review interventions 3 types outcomes 4 measurement instruments used systematic literature search randomized controlled trials cpled medication reviews carried pubmed cochrane library information patient selection intervention components outcome measurements extracted frequencies analyzed possible outcomes mapped core outcome set cos medication review studies finally network analysis conducted explore influence individual factors outcome effects total 30 articles 26 studies included articles drug classspecific diseasespecific patient selection criterion n 19 half articles included patients aged 60 years n 15 40 n 1230 patients taking 4 drugs 24 30 articles medication review comprised additional interventions distribution educational material training followup visits 40 different outcomes extracted within specific outcomes measurement instruments varied cos rarely represented revealed differences patient selection intervention delivery outcome assessment highlight need standardization research cpled medication reviews intervention delivery precisely described capture potential differences interventions outcome assessment standardized terms outcome selection application cos regard selected core outcome measurement instruments enable comparison results