Booil Jo|Tihomir Asparouhov|Bengt Muthén
Intention?to?treat analysis in cluster randomized trials with noncompliance
Stanford University|Muthén & Muthén (United States)|University of California, Los Angeles
abstract cluster randomized trials crts individuals belonging cluster likely resemble one another terms outcomes also terms treatment compliance behavior although impact resemblance outcomes well acknowledged little attention given possible impact resemblance compliance behavior study defines compliance intraclass correlation level resemblance compliance behavior among individuals within clusters basis monte carlo simulations demonstrated compliance intraclass correlation affects power detect intentiontotreat itt effect crt setting way improving power detect itt effect crts accompanied noncompliance study employs estimation method itt effect estimates obtained based compliancetypespecific treatment effect estimates multilevel mixture analysis using mlem estimation method used estimation copyright 2008 john wiley amp sons ltd