Anthony Ngugi|Christian Bottomley|Eddie Chengo|Martha Kombe|Michael Kazungu|Evasius Bauni|Caroline K. Mbuba|Immo Kleinschmidt|Charles R. Newton
The validation of a three-stage screening methodology for detecting active convulsive epilepsy in population-based studies in health and demographic surveillance systems
Kenya Medical Research Institute|London School of Hygiene & Tropical Medicine|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|London School of Hygiene & Tropical Medicine|Indepth Network
studies epidemiology epilepsy large populations low middle income countries lmic studies regions use twostage populationbased screening surveys timeconsuming costly implement large populations required generate accurate estimates examined sensitivity specificity threestage crosssectional screening methodology detecting active convulsive epilepsy ace embedded within ongoing census demographic surveillance systemswe validated threestage crosssectional screening methodology randomly selected sample participants threestage prevalence survey epilepsy diagnosis ace experienced clinician used gold standard compared expenditure method standard twostage methodologywe screened 4442 subjects validation identified 35 cases ace 18 identified false negatives 1518 missed first stage 318 second stage threestage screening overall methodology sensitivity 486 specificity 100 37 cheaper twostage surveythis first study evaluate performance multistage screening methodology used detect epilepsy demographic surveillance sites method poor sensitivity attributed mainly stigmarelated nonresponse first stage method needs take consideration poor sensitivity savings expenditure time well validation target populations findings suggest need continued efforts develop improve caseascertainment methods populationbased epidemiological studies epilepsy lmic