L G Clearkin|Balasubramanian Ramasamy|James Wason|Stephenie Tiew
Anti-VEGF intervention in neovascular AMD: benefits and risks restated as natural frequencies
Wirral University Teaching Hospital NHS Foundation Trust|University of Liverpool|Wirral University Teaching Hospital NHS Foundation Trust|MRC Biostatistics Unit|Wirral University Teaching Hospital NHS Foundation Trust
clear information essential properly determine preference medical intervention neovascular agerelated macular degeneration patients need understand balance risk benefit antivascular endothelial growth factor vegf treatment balance altered number injections administerednatural frequencies displayed pictographically icon arrays used show material outcomes marina harbor 12 months trials also calculated number needed treat nnt number needed harm nnhmarina 24month data show absolute risk reduction 37 nnt 3 meaning one patient benefit three need treated12 months harbor data show compared asneeded treatment scheduled monthly injection treatment increases number patients achieving better visual outcome number patients suffering harm also increased additional injectionsdisplaying marina harbor trial data natural frequencies numbers needed treat harm communicates complimentary information positive negative aspects antivegf treatment