Sunil Sazawal|Usha Dhingra|Girish Hiremath|Archana Sarkar|Pratibha Dhingra|Arup Dutta|Priti Verma|Venugopal P. Menon|Robert E. Black
Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial
Annamalai University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Annamalai University|Annamalai University|Johns Hopkins University|Annamalai University|Annamalai University|Johns Hopkins University
recent reviews suggest common infectious diseases continue major cause death among preschool children developing countries identification feasible strategies combat disease burden important public health need evaluated efficacy adding prebiotic oligosaccharide probiotic bifidobacterium lactis hn019 milk preventing diarrhea respiratory infections severe illnesses children aged 14 years part four group study design running two studies simultaneouslyin community based doublemasked randomized controlled trial children 13 years age willing participate randomly allocated receive either control milk co n 312 milk fortified 24 gday prebiotic oligosaccharide 19x107 colony forming unit cfuday probiotic bifidobacterium lactis hn019 pp n 312 children followed 1 year providing data 14 years biweekly household surveillance conducted gather information compliance morbidity study groups comparable baseline compliance intervention similar overall effect prebiotic probiotic diarrhea 6 reduction 95 confidence interval ci 1 12 p 008 incidence dysentery episodes reduced 21 95 ci 0 38 p 005 incidence pneumonia reduced 24 95 ci 0 42 p 005 severe acute lower respiratory infection alri 35 95 ci 0 58 p 005 compared children co group children pp group 16 95 ci 5 26 p 0004 5 95 ci 0 10 p 005 reduction days severe illness high fever respectivelymilk good medium delivery prebiotic probiotic resulted significant reduction dysentery respiratory morbidity febrile illness overall impact diarrhea significant findings need confirmation settings