Alka M. Kanaya
Total and Regional Adiposity and Cognitive Change in Older Adults
University of California, San Francisco|National Institute on Aging|University of Pittsburgh|University of Tennessee at Knoxville
objectives investigate whether total andor regional adiposity measured anthropometry radiographic studies influences cognitive decline older adults whether association explained hormones inflammatory factors known secreted adipose tissuedesign prospective cohort studysetting two clinical centersparticipants three thousand fiftyfour elderly individuals enrolled health abc studyadiposity measures included body mass index waist circumference sagittal diameter total fat mass dualenergy xray absorptiometry subcutaneous visceral fat abdominal computed tomographywe examined association baseline body fat measures change modified minimental state examination 3ms score sequentially adjusting confounding mediating variables including comorbid diseases adipocytokines sex hormonesmain outcome measure scores 3ms administered first third fifth eighth annual clinical examinationsresults baseline adiposity measures varied significantly sexin mixedeffects models association total regional adiposity change 3ms score varied significantly sex highest adiposity tertile associated greater cognitive declines men adiposity measure p05 women interaction p05total fat mass significantly associated greater change 3ms scores among men lowest tertile 16 middle tertile 22 highest tertile 27 p006 even adjusting mediatorsconclusions higher levels adiposity measures associated worsening cognitive function men controlling metabolic disorders adipocytokines sex hormone levelsconversely association adiposity cognitive change women