Hannan Yang, D Y Lin, Quefeng Li
An Efficient Greedy Search Algorithm for High-dimensional Linear Discriminant Analysis
Statistica Sinica
longterm use inhaled corticosteroids icss associated several potential adverse effects patients unlikely benefit stop ics use abrupt discontinuation may result increased risk chronic obstructive pulmonary disease copd exacerbation stepwise tapering may reduce risk data limited consensus likelihood copd exacerbations following ics discontinuation north texas veterans affairs health care system conducted single center retrospective cohort study evaluate rate copd exacerbations following discontinuation ics therapy using different schedules discontinuation data collected electronic health records patients aged 40 years diagnosis copd stable dose ics 1 year subsequently discontinued last documented fill date january 10 2021 september 1 2021 eligible patients followed copd exacerbations resulted hospitalization november 1 2022 descriptive statistics used evaluate characteristics patients experienced exacerbation seventyfive patients included 5 7 experienced exacerbation following ics discontinuation age sex race ethnicity similar patients vs exacerbation unexpectedly mean baseline eosinophil count patients exacerbation 92 cellsl compared 2274 cellsl without exacerbation nine patients ics tapered gradually none experienced exacerbation study findings suggest relatively low risk copd exacerbation following ics discontinuation regardless whether taper performed result may indicate reasonable abruptly discontinue ics eligible patients