Gwendolyn P. Quinn|Tuya Pal|Devin Murphy|Susan T. Vadaparampil|Amit Kumar
High-risk consumers’ perceptions of preimplantation genetic diagnosis for hereditary cancers: a systematic review and meta-analysis
Moffitt Cancer Center|University of South Florida|Moffitt Cancer Center|University of South Florida|Miller Children's & Women's Hospital|Children's Cancer Center|Moffitt Cancer Center|University of South Florida|Moffitt Cancer Center|University of South Florida
individuals carrying deleterious germline mutations placing increased risk hereditary cancer syndromes highrisk consumers often great deal fear concern transmitting mutations offspring particularly conditions autosomal dominant preimplantation genetic diagnosis pgd procedure detect certain germline cancer predisposing mutations present embryos objective review assess highrisk consumers knowledge perceptions pgd hereditary cancers systematic literature review conducted pubmed wiley interscience psychinfo cochrane library databases identify articles assessing consumer knowledge attitudes pgd hereditary cancer syndromes assessed heterogeneity robustness findings additional analyses according study location hereditary cancer type sample size thirteen articles remained eligible application specific criteria results show general low level knowledge pgd hereditary cancers moderate rates acceptability among highrisk groups high levels need information pgd individuals specific risk groups personal family history hereditary breast ovarian cancer hboc syndrome familial adenomatous polyposis fap may benefit educational information healthcare professionals use pgd