Hyo Sung Cha, Sook Ja Yang
The Longitudinal Mediating Effects of Perceived Parental Neglect on Changes in Korean Adolescents' Life Satisfaction by Gender
Asian nursing research
evaluate efficacy safety cetuximab instead cisplatin combination downstaging radiotherapy papillomavirus hpv positive oropharyngeal squamous cell carcinoma hpv opscc metaanalysis systematic evaluation pubmed embase web science cochrane library databases searched june 8 2023 well clinicaltrialsgov clinical trials registry china knowledge network wanfang data knowledge service platform wiprojournalcom randomized controlled trials reporting results standard regimens cetuximab radiotherapy vs cisplatin radiotherapy treating hpv opscc included primary outcomes interest overall survival os progressionfree survival pfs local regional failure rate lrf distant metastasis rate dm adverse events ae two reviewers independently extracted data assessed risk bias included studies hr 95 ci used effect analysis statistic survival analysis 95 ci used effect analysis statistic dichotomous variables statistics extracted reviewers aggregated using fixedeffects model synthesise data total 874 relevant papers obtained initial search five papers met inclusion criteria included total 1617 patients hpv opscc enrolled studies metaanalysis showed os pfs significantly shorter cetuximab radiotherapy group patients hpv opscc compared conventional cisplatin radiotherapy group hr 210 95 ci 139315 p 00004 hr 179 95 ci 140229 p 00001 lrf dm significantly increased hr 222 95 ci 158311 p 00001 hr 166 95 ci 107258 p 002 significant difference overall grade 3 4 acute late ae overall 086 95 ci 065113 p 028 cisplatin radiotherapy remains standard treatment hpv opscc according 7th edition ajccuicc criteria lowrisk hpv opscc patients smoking history 10 packsyear nonpharyngeal tumors involved lymphatic metastasis similar survival outcomes cetuximabcisplatin radiotherapy however clinical trials necessary determine whether cetuximab radiotherapy replace cisplatin radiotherapy degraded treatment individuals meet aforementioned characteristics particularly platinum drug allergies crd42023445619