Yuhong Chen|Jieli Lu|Yun Huang|Tiange Wang|Yu Xu|Min Xu|Mian Li|Weiqing Wang|Donghui Li|Yufang Bi|Guang Ning
Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China
Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|The University of Texas MD Anderson Cancer Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center|Shanghai Institute of Hematology|Shanghai Jiao Tong University|Shanghai Clinical Research Center
schistosome antigens modulate host metabolic profiles reduce risk diabetes experimental animals association previously examined humansthe objective study evaluate whether previous schistosome infection psi related development diabetes metabolic syndromea crosssectional study conducted 9539 participants aged 40 years older rural community chinainformation history schistosome infection collected personal interview crossreferenced local infectious disease registry associations psi diabetes metabolic profiles evaluated using logistic regression models participants aged 60 years older n 3913participants psi n 463 significantly lower levels adjusted fasting blood glucose postprandial blood glucose glycated hemoglobin a1c homeostasis model assessment insulin resistance well lower prevalence diabetes 149 vs 254 p 0001 metabolic syndrome 140 vs 350 p 0001 compared uninfected contemporaneous controls n 3450 logistic regression analysis revealed adjusted odds ratios 95 confidence interval prevalent diabetes metabolic syndrome associated psi 051 034077 040 027058 respectivelythe associations psi lower prevalence diabetes better metabolic profile rural chinese need confirmed populations confirmed protecting effect helminth infection could reconsidered terms therapeutic strategies treatment diabetes metabolic diseases