Chih?Chiang Chiu|Sophia Frangou|Ching?Jui Chang|Wei?Che Chiu|Hsing?Cheng Liu|I-Wen Sun|Shen?Ing Liu|Mong Liang Lu|Chun-Hsin Chen|Shih?Yi Huang|Michael Dewey|Robert Stewart
Associations between n?3 PUFA concentrations and cognitive function after recovery from late-life depression
Taipei City Hospital
lower concentrations n3 pufas reported associated cognitive impairment dementia also depressionitself potential risk factor cognitive declinethe aims study investigate associations n3 pufa concentrations erythrocyte membrane plasma cognitive function atrisk sample older people previous major depression explore specificity respect cognitive domainsa crosssectional sample 132 eligible participants recovered major depression mean sd age 678 66 enrolled outpatient psychiatric services series cognitive tests structured questionnaire administered fasting blood samples collected n3 pufa measurementshigher epa total n3 pufa concentrations lower ratio arachidonic acid epa erythrocyte membranes associated higher cognitive composite score independent age sex longer significant adjustment education associations found plasma concentrations fatty acid considering individual cognitive tests strongest consistent correlations found immediate recall concentrations total n3 pufas linolenic acid ala erythrocytes observed participants recurrent depressiontotal erythrocyte n3 pufa concentrations positively associated cognitive function particularly immediate recall older people previous depression lower concentrations n3 pufas ala erythrocyte membranes may good predictors cognitive impairment older people previous recurrent depression