Mary C. Politi|Marie D. Kuzemchak|Kimberly A. Kaphingst|Hannah Perkins|Jingxia Liu|Margaret M. Byrne
Decision Aids Can Support Cancer Clinical Trials Decisions: Results of a Randomized Trial
Washington University in St. Louis|Washington University in St. Louis|Huntsman Cancer Institute|University of Utah|Washington University in St. Louis|Washington University in St. Louis|Sylvester Comprehensive Cancer Center|University of Miami
cancer patients often make informed decisions regarding clinical trial participation study evaluated whether webbased decision aid da could support trial decisions compared cancer centers websiteadults diagnosed cancer past 6 months previously participated cancer clinical trial eligible participants randomized view da cancer centers website enhanced usual care uc controlling whether participants heard cancer clinical trials educational attainment multivariable linear regression examined group knowledge selfefficacy finding trial information decisional conflict values clarity uncertainty intent participate decision readiness trial perceptionstwo hundred patients 86 consented may 2014 april 2015 one hundred randomized group surveys completed 87 da group 90 uc group da group participants reported clearer values regarding trial participation uc group participants reported least squares ls mean 158 vs 32 p 0001 less uncertainty ls mean 243 vs 364 p 025 da group higher objective knowledge uc groups ls mean 698 vs 558 p 0001 differences groups intent participateimprovements key decision outcomes including knowledge selfefficacy certainty choice values clarity among participants viewed da suggest webbased das support informed decisions trial participation among cancer patients facing preferencesensitive choice although better informing patients trial participation could improve retention work needed examine da impact enrollment retentionthis paper describes evidence regarding decision tool support patients decisions trial participation improving knowledge helping patients clarify preferences participation facilitating conversations trials decision aids could lead decisions participation better match patients preferences promoting patientcentered care ethical conduct clinical research