Kimberly A Clevenger, Melitta A McNarry, Kelly A Mackintosh, David Berrigan
Association of Recess Provision With Elementary School-Aged Children's Physical Activity, Adiposity, and Cardiorespiratory and Muscular Fitness
Pediatric exercise science
role germline genetic testing urologic oncology expanded recent years however implementation genetic testing community practices remains challenge often due limited access qualified genetics trained providers study report outcomes universal germline screening program community urology practice november 2021 september 2022 patients referred urology clinic visits frederick health frederick md usa provided online genetics screening questionnaire prior visit responses compared national comprehensive cancer network nccn criteria germline testing met criteria provided educational materials end questionnaire counseled trained urologic oncologist hc clinic referred genetic counselor prior testing testing performed 36gene pancancer panel cancernext 14gene targeted prostate cancer panel prostatenext without additional rna analysis rnainsight ambry genetics ca usa demographic clinical parameters well genetic testing results retrospectively collected irb approval study period 765 patients seen 1370 clinic visits 505 patients 660 completed screening questionnaire majority completed via email 545 remainder 455 via text message patients completed screening 125505 247 met nccn criteria germline testing 58125 patients 464 met criteria underwent germline testing 558 86 distinct pathogenic mutations identified included actionable mutations brca1 brca2 chek2 well additional pathogenic mutation nbn variants unknown significance identified 858 patients 138 11 total genes challenges implementation program included meeting institutional requirements genetic testing consent facilitating specimen collection clinic integration results electronic health record genetic risk assessment highrisk individuals feasible part universal screening program community urology practice approximately 8 tested patients found pathogenic germline mutations consistent contemporary tertiary referral cohorts