Gain Lee, Yuna Park, Jeongseob Kim, Gi-Hyoug Cho
Association between intersection characteristics and perceived crash risk among school-aged children
Accident; analysis and prevention
several genetic factors associated cognitive decline aging apolipoprotein e apoe 4 widely studied risk pathological cognitive decline including dementia however association apoe 4 cognitive functioning healthy aging indian population understudied results ambiguous study aims examine role apoe genotype attentional function aging adults 45 years rural indian population crosssectional baseline data n 2100 utilized ongoing longitudinal cohort study aging srinivaspura aging neurosenescence cognition study participants hailed villages srinivaspura karnataka southern india participants categorized based apoe4 status three categories 4 heterozygous 4 homozygous 4 attentional function assessed using auditory visual attention subtests computerized neurocognitive test battery linear regression performed adjusting age gender education model 1 unadjusted find association apoe attention function partially adjusted model 2 adjusting age apoe 4 age significantly associated attention function increasing age decline attention among homozygous 4 individuals model 3 model 2 gender found apoe 4 age gender explained significant variance attention function addition increasing age males poor attention homozygous compared heterozygous group model 4 model 3 education explained significant variance attention also revealed increasing age attention declined illiterate low literacy groups homozygous heterozygous groups among genders although apoe 4 alone associated interacted age gender education affect attention function rural indian population longitudinal cognitive monitoring yield insights understanding whether apoe 4 genotype influences rate cognitive decline rural aging population