Li Wei, Ju-Yang Chi, Jane C-J Chao, Yen-Nung Lin
An Intelligent Cardiopulmonary Training System and Adherence to Training Intensity: A Feasibility Study
International journal of environmental research and public health
study assessed diffusion tensor imaging dti metrics fractional anisotropy fa mean diffusivity md radial diffusivity rd pediatric subjects epilepsy secondary focal cortical dysplasia fcd improve understanding structural network changes associated fcd related epilepsy utilized data harmonization dh approach minimize confounding effects induced mri protocol differences also assessed correlations dti metrics neurocognitive measures fluid reasoning index fri verbal comprehension index vci visuospatial index vsi data n 51 23 fcd patients 28 typically developing controls td scanned clinically either 15t 3t 3twidebore mri retrospectively analyzed tractbased spatial statistics tbss thresholdfree cluster enhancement permutation testing 100000 permutations used statistical analysis account imaging protocol differences employed nonparametric data harmonization prior permutation testing analysis demonstrates dh effectively removed mri protocolbased differences typical clinical acquisitions preserving group differences dti metrics fcd td subjects furthermore dh strengthened association dti metrics neurocognitive indices fractional anisotropy md rd metrics showed stronger correlation fri vsi vci results demonstrate dh integral step reduce confounding effect mri protocol differences analysis white matter tracts highlights biological differences fcd healthy control subjects characterization white matter changes associated fcdrelated epilepsy may better inform prognosis treatment approaches