Kimberly A. Kaphingst|Jennifer Ivanovich|Sarah Lyons|Barbara Biesecker|Rebecca Dresser|Ashley Elrick|Cindy Matsen|Melody S. Goodman
Preferences for learning different types of genome sequencing results among young breast cancer patients: Role of psychological and clinical factors
Huntsman Cancer Institute|University of Utah|Washington University in St. Louis|Washington University in St. Louis|National Human Genome Research Institute|Washington University in St. Louis|Huntsman Cancer Institute|University of Utah|Huntsman Cancer Institute|University of Utah|New York College of Health Professions|New York University
growing importance genome sequencing means patients increasingly face decisions regarding results would like learn present study examined psychological clinical factors might affect preferences 1080 women diagnosed breast cancer age 40 younger completed online survey assessed interest learning various types genome sequencing results risk preventable disease unpreventable disease cancer treatment response uncertain meaning risk relatives health ancestryphysical traits multivariable logistic regression used examine whether interested result type associated clinical factors brca12 mutation status prior genetic testing family history breast cancer psychological factors cancer recurrence worry genetic risk worry future orientation health information orientation genome sequencing knowledge proportion respondents interested learning type result ranged 16 77 multivariable models interested learning result type significantly higher knowledge sequencing benefits greater genetic risks worry stronger health information orientation compared less interest pvalues 05 findings indicate high interest return various types genome sequencing results closely related psychological factors shared decisionmaking approaches increase knowledge genome sequencing incorporate patient preferences health information learning genetic risks may help support patients informed choices learning different types sequencing results