Alan T Rodriguez-Penney|Jennifer E. Iudicello|Patricia K. Riggs|Katie Doyle|Ronald J. Ellis|Scott Letendre|Igor Grant|Aimee Woods
Co-Morbidities in Persons Infected with HIV: Increased Burden with Older Age and Negative Effects on Health-Related Quality of Life
University of Puerto Rico System|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego
study sought determine synergistic effects age hiv infection medical comorbidity burden along clinical correlates impact healthrelated quality life hrqol across lifespan hiv participants included 262 individuals across four groups stratified age 40 50 years hiv serostatus medical comorbidity burden assessed using modified version charlson comorbidity index cci multiple regression accounting potentially confounding demographic psychiatric medical factors revealed interaction age hiv infection cci highest medical comorbidity burden older hivcohort nearly half older hivgroup least one major medical comorbidity prevalent diabetes 178 syndromic neurocognitive impairment 154 malignancy 122 affective distress detectable plasma viral load significantly associated cci younger older hivinfected groups respectively greater comorbidity burden uniquely associated lower physical hrqol across lifespan findings highlight prevalence clinical impact comorbidities older hivinfected adults underscore importance early detection treatment efforts might enhance hiv disease outcomes