Jason Steffener|Yaakov Stern
Exploring the neural basis of cognitive reserve in aging
Columbia University|Columbia University
concept reserve arose mismatch extent brain changes pathology clinical manifestations brain changes cognitive reserve hypothesis posits individual differences flexibility adaptability brain networks underlying cognitive function may allow people cope better brain changes others although ample epidemiologic evidence cognitive reserve neural substrate reserve still topic ongoing research review representative studies group exemplify possibilities neural substrate reserve including neural reserve neural compensation generalized cognitive reserve networks also present schematic overview ongoing research area article part special issue entitled imaging brain aging neurodegenerative disease