A S Detsky, G Naglie, M D Krahn, D Naimark, D A Redelmeier
Primer on medical decision analysis: Part 1--Getting started
Medical decision making : an international journal of the Society for Medical Decision Making
development universal influenza virus vaccine protect seasonal pandemic influenza viruses longstanding public health goal conserved stalk domain haemagglutinin ha promising vaccine target however stalk immunosubdominant innovative approaches required elicit robust immunity domain previously reported observerblind randomised placebocontrolled phase trial nct03300050 immunisation regimens using chimeric ha chabased immunogens formulated inactivated influenza vaccines iiv as03 adjuvant live attenuated influenza vaccines laiv elicited durable ha stalkspecific antibodies broad reactivity study sought determine vaccines could also boost cell responses ha stalk nucleoprotein np measured interferon ifn responses enzymelinked immunospot elispot assay baseline seven days postprime preboost seven days postboost following heterologous primeboost regimens laiv andor adjuvantedunadjuvanted iivcha vaccines findings demonstrate immunisation adjuvanted chabased iivs boost ha stalkspecific npspecific cell responses humans date unclear ha stalkspecific cells boosted humans hastalk focused universal vaccines therefore study provide valuable insights design future studies determine precise role ha stalkspecific cells broad protection considering chabased vaccines also elicit stalkspecific antibodies data support clinical advancement chabased universal influenza vaccine candidates study funded part bill melinda gates foundation bmgf