Jiaonan Wang|Tiantian Li|Yuebin Lv|Virginia B. Kraus|Yi Zhang|Mao Chen|Zhaoxue Yin|Wanying Shi|Jinhui Zhou|Tongzhang Zheng|Patrick L. Kinney|John S. Ji|Song Tang|Xiaoming Shi
Fine Particulate Matter and Poor Cognitive Function among Chinese Older Adults: Evidence from a Community-Based, 12-Year Prospective Cohort Study
Chinese Center For Disease Control and Prevention|Nanjing Medical University|Chinese Center For Disease Control and Prevention|Nanjing Medical University|Chinese Center For Disease Control and Prevention|Duke University|Chinese Center For Disease Control and Prevention|Southern Medical University|Chinese Center For Disease Control and Prevention|Chinese Center For Disease Control and Prevention|Chinese Center For Disease Control and Prevention|Brown University|Providence College|Boston University|Duke Kunshan University|Duke University|Chinese Center For Disease Control and Prevention|Nanjing Medical University|Chinese Center For Disease Control and Prevention|Nanjing Medical University
background research relationship longterm exposure particulate matter aerodynamic diameter 25 lm pm 25 poor cognitive function lacking developing countries especially highly polluted areasobjectives evaluated associations longterm exposure pm 25 poor cognitive function diverse national sample older adults chinamethods analysis included data 13324 older adults 5879 6579 years age 3052 8089 years age 2634 9099 years age 1759 100 years age normal cognitive function baseline march 2002 september 2014 64648 personyears followupwe used geographic information system analysis estimate annual average satellitederived pm 25 concentration geocoded location participants baseline residencespoor cognitive function defined score less 18 chinese version minimental state examination mmsecompeting risk models performed explore association pm 25 poor cognitive functionresults 10lgm 3 increase pm 25 associated 51 increased risk poor cognitive function adjusted hazard ratio hr 1051 95 confidence interval ci 1023 1079compared lowest quartile pm 25 414 lgm 3 adjusted hr values 120 95 ci 109 133 127 95 ci 115 141 121 95 ci 109 134 second 414503 ugm 3 third 503607lgm 3 fourth 607 lgm 3 quartiles pm 25 respectively p trend 0001subgroup analyses suggested stronger associations pm 25 poor cognitive impairment men womenthe association positive 65to 79and 100y age group significant positive two age groups similar resultsconclusion pm 25 identified risk factor poor cognitive function chinese older adultsimproving air quality may reduce future population burden poor cognitive function especially areas high air pollution