Mary Mahieu|Grace E. Ahn|Joan S. Chmiel|Dorothy D. Dunlop|Irene Helenowski|Pamela A. Semanik|Jing Song|Susan Yount|Rowland W. Chang|Rosalind Ramsey?Goldman
Fatigue, patient reported outcomes, and objective measurement of physical activity in systemic lupus erythematosus
Northwestern University|Northwestern University|Arthritis and Rheumatism Associates|Northwestern University|Northwestern University|Northwestern University|Rush University|Northwestern University|Northwestern University|Northwestern University|Northwestern University
objective fatigue common symptom systemic lupus erythematosus sle engaging physical activity may reduce fatigue aimed characterize relationships fatigue health status measures assessed patient reported outcomes measurement information system promis instruments accelerometerbased physical activity measurements patients sle internal consistency promis measure sle sample also evaluated methods crosssectional study analyzed 123 adults sle primary fatigue outcome fatigue severity scale score secondary outcomes promis standardized tscores seven health status domains accelerometers worn seven days mean daily minutes light moderatevigorous bouted 10 minutes moderatevigorous physical activity estimated cronbachs alpha determined promis measure assess internal consistency relationships fatigue severity scale promis physical activity summarized spearman partial correlation coefficients r adjusted average daily accelerometer wear time results mean fatigue severity scale score 43 sd 16 consistent clinically relevant levels fatigue greater daily bouted moderatevigorous physical activity minutes correlated lower mean fatigue severity scale score r 020 p 003 r 030 p 00007 respectively promis bouted moderatevigorous physical activity minutes correlated less fatigue r 020 p 003 promis internal consistency excellent cronbachs alpha gt 090 domain mean promis tscores fatigue pain interference anxiety sleep disturbance sleeprelated impairment physical function worse reported general us population moderatevigorous physical activity minutes associated less pain interference r 022 p 001 light physical activity moderatevigorous physical activity minutes correlated better physical function r 019 p 004 r 025 p 0006 respectively conclusion time spent moderatevigorous physical activity associated less fatigue fatigue severity scale promis less pain interference better physical function promis promis excellent internal consistency sle sample six seven promis measures indicated poorer average health status sle patients compared general us population