Ingrid V Bassett, Joyce Yan, Janet Giddy, Douglas Ross, Laura M Bogart, Ashley Stuckwisch, Dani Zionts, Ravi Naidoo, Robert A Parker
Geographic variation in 5-year mortality following HIV diagnosis: implications for clinical interventions
AIDS care
acute myeloid leukemia aml malignant clonal hematopoietic disease poor prognosis understanding interaction leukemic cells tumor microenvironment tme help predict prognosis leukemia guide treatment reanalyzing scrnaseq data csc g20 cohorts using pythonbased pipeline including machinelearningbased scvitools recapitulated distinct hierarchical structure within samples aml patients weighted correlation network analysis wgcna conducted construct weighted gene coexpression network identify gene modules primarily focusing hematopoietic stem cells hscs multipotent progenitors mpps natural killer nk cells analysis revealed significant deregulation gene modules associated aerobic respiration ribosomalcytoplasmic translation cellcell communications elucidated cellchat package revealing imbalance activating inhibitory immune signaling pathways interception genes upregulated leukemic hscs mpps well nkg2ahigh nk cells used construct prognostic models normal cox artificial neural network models based 10 genes developed study reveals deregulation mitochondrial ribosomal genes aml patients suggests cooccurrence stimulatory inhibitory factors aml tme