Parul Christian|Mary E. Morgan|Laura E. Murray?Kolb|Steven C. LeClerq|Subarna K. Khatry|Barbara A. Schaefer|Pamela M. Cole|Joanne Katz|Tielsch Tielsch
Preschool Iron-Folic Acid and Zinc Supplementation in Children Exposed to Iron-Folic Acid in Utero Confers No Added Cognitive Benefit in Early School-Age
Johns Hopkins University|Johns Hopkins University|Pennsylvania State University|Johns Hopkins University|Tilganga Institute of Ophthalmology|Johns Hopkins University|Tilganga Institute of Ophthalmology|Pennsylvania State University|Pennsylvania State University|Johns Hopkins University|Johns Hopkins University
nepal antenatal ironfolic acid supplementation improved aspects intellectual executive fine motor function among schoolage children examined impact added zinc maternal antenatal supplement mifazn preschool supplementation 12 36 mo ironfolic acid cifa zinc cifazn cognitive outcomes compared maternal ironfolic acid mifa alone children 79 old n 780 participated early childhood micronutrient supplementation trial 20012004 whose mothers participated antenatal micronutrient supplementation 1999 2001 followed cognitive assessments 20072009 using multivariate analysis variance adjusting confounders mifa child supplementation either cifa cifazn impact scores tests general intelligence universal nonverbal intelligence test executive function stroop gono go tests relative mifa alone however children cifazn group slightly lower scores backward digit span 029 95 ci 055 004 movement assessment battery children 133 95 ci 026 240 relative referent group whereas cifa 192 95 ci 312 071 cifazn 178 95 ci 263 092 produced somewhat lower finger tapping test scores fine motor skills combination mifazn cifa cifazn lead outcome differences relative mifa alone preschool ironfolic acid zinc children exposed ironfolic acid utero addition zinc maternal ironfolic acid conferred additional benefit cognitive outcomes assessed early school age late timing supplementation preschool may explain lack impact iron andor zinc