Cathrine F Hjorth, Line Bilgrav, Louise Sjørslev Frandsen, Charlotte Overgaard, Christian Torp-Pedersen, Berit Nielsen, Henrik Bøggild
Mental health and school dropout across educational levels and genders: a 4.8-year follow-up study
BMC public health
provide comprehensive quantitative review neurocognitive function sickle cell disease scd across multiple domains cerebral infarct status lifespan one hundred ten studies identified pubmed medline psycinfo involving 110 studies 3600 participants scd 1127 sibling health controls metaanalytic findings indicate significant deficits across neurocognitive domains age groups infarct status significant deficits relative normative mean ranged hedges g 39 g 63 preschool children g 83 g 118 schoolaged children adolescents g 46 g 86 adults deficits full scale iq fsiq verbal reasoning perceptual reasoning executive function increased preschool schoolaged samples however findings also showed deficits smaller adult samples relative schoolaged samples likely due sampling bias adult studies findings across infarct status sickle cell anemia showed deficits ranged g 54 g 65 samples without infarcts g 52 g 103 samples silent cerebral infarct g 135 g 182 samples stroke deficits domain increased magnitude infarct stroke silent cerebral infarct overt stroke individuals scd risk cognitive deficits across domains infarct status lifespan research necessary determine unbiased effects cognitive function adults scd