John Read|Richard P. Bentall|Roar Fosse
Time to abandon the bio-bio-bio model of psychosis: Exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic symptoms
University of Auckland|University of Auckland
abstract mental health services research dominated several decades rather simplistic reductionistic focus biological phenomena minimal consideration social context within genes brains inevitably operate medical model ideology enthusiastically supported pharmaceutical industry particularly powerful field psychosis led unjustified damaging pessimism recovery failure find robust evidence genetic predisposition psychosis general schizophrenia particular understood terms recently developed knowledge epigenetic processes turn gene transcription mechanisms highly influenced individuals socioenvironmental experiences understand emerging evidence relationship adverse childhood events subsequent psychosis necessary integrate epigenetic processes especially involving stress regulating functions hpa axis research psychological mechanisms specific types childhood trauma lead specific types psychotic experiences implications research mental health services primary prevention profound declaration interest none authors conflicts interest relation paper