Laura C Hopkins, Christopher Holloman, Bernadette Melnyk, Mary Fristad, Jacqueline D Goodway, Julie A Kennel, Ihuoma Eneli, Carolyn Gunther
Participation in structured programming may prevent unhealthy weight gain during the summer in school-aged children from low-income neighbourhoods: feasibility, fidelity and preliminary efficacy findings from the Camp NERF study
Public health nutrition
schizophrenia sz severe mental disorder characterized failure functional integration aka dysconnection across brain recent functional connectivity fc studies adopted functional parcellations define subnetworks largescale networks characterize dysconnection normal clinical populations fc examines statistical dependencies observations modelbased effective connectivity ec disclose causal influences underwrite observed dependencies study investigated resting state ec within seven largescale networks 66 sz 74 healthy subjects public dataset results showed remarkable 33 effective connections among subnetworks cognitive control network pathologically modulated sz dysconnection identified within visual default mode sensorimotor networks sz subjects 24 20 11 aberrant couplings overall proportion discriminative connections remarkably larger ec 24 fc 1 analysis subsequently study neural correlates impaired cognition sz conducted canonical correlation analysis ec parameters cognitive scores patients selfinhibitions supplementary motor area paracentral lobule sensorimotor network excitatory connection parahippocampal gyrus inferior temporal gyrus cognitive control network significantly correlated social cognition reasoningproblem solving working memory capabilities patients future research investigate potential wholebrain ec biomarker diagnosis brain disorders neuroimagingbased cognitive assessment