Mohsen Najjari, Mohammad Amin Gorouhi, Hossein Zarrinfar, Bibi Razieh Hosseini Farash, Jamshid Jamali, Elham Moghaddas, Mohammad Ebrahimipuor
Impact of a health educational interventional program on reducing the head lice infestation among pupils in an elementary school of a sub-tropical region: a quasi-experimental study
BMC pediatrics
pregnancy air pollution exposure pape linked wide range adverse birth childhood outcomes paucity data influence placental epigenome regulate programming physiological functions affect child development study aimed investigate association prenatal air pollutant exposure concentrations changes placental dna methylation patterns explore potential windows susceptibility sexspecific alterations multisite study used three prospective populationbased motherchild cohorts eden pelagie sepages originating four french geographical regions nancy poitiers brittany grenoble pregnant women included 2003 2006 eden pelagie 2014 2017 sepages main eligibility criteria older 18 years singleton pregnancy living planning deliver one maternity clinics one study areas total 1539 motherchild pairs analysed measuring placental dna methylation using illumina beadchips used validated spatiotemporally resolved models estimate pm25 pm10 no2 exposure trimester pregnancy maternal residential address conducted pooled adjusted epigenomewide association study identify differentially methylated 5cphosphateg3 cpg sites regions assessed using infinium humanmethylationepic beadchip array n871 including sexspecific sexlinked alterations independently validated results assessed using infinium humanmethylation450 beadchip array n668 identified four cpgs 28 regions associated pape total population 469 cpgs 87 regions male infants 150 cpgs 66 regions female infants validated 35 cpgs available 30 identified cpgs related one birth outcome significant alterations enriched neural development immunity metabolism related genes 28 regions identified sexes overlapped imprinted genes four genes associated neurodevelopment nine genes immune system seven genes metabolism five genes associations observed third trimester female infants 134 150 cpgs throughout pregnancy 281 469 cpgs first trimester 237 469 cpgs male infants findings highlight molecular pathways pape might affect child health widespread sexspecific manner identifying genes involved major physiological functions developing child studies needed elucidate whether epigenetic changes persist affect health later life french agency national research fondation pour la recherche mdicale fondation de france plan cancer