Kumi Tenjin, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse
Relationship Between Parental Lifestyle and Dietary Habits of Children: A Cross-Sectional Study
Journal of epidemiology
radiotherapy recommended treatment brain tumors glioblastoma gbm brain metastases various curative palliative scenarios suggest improved localregional control although underlying mechanisms yet clear additional therapeutic effects described including proximity abscopal reactions treatment site clinical preclinical data suggest immune system plays essential role regulating nontargeted effects radiotherapy gbm article reviews current biological mechanisms regulating nontargeted effects caused external internal radiotherapy might applied clinical context optimization therapeutic regimens requires assessment complexity host immune system activity immunosuppressive immunostimulatory cells gliomaassociated macrophages microglia article also discusses recent preclinical models adapted postradiotherapy responses narrative review explores discusses current status immune responses locally via bystander effect remotely via abscopal effect preclinical clinical observations demonstrate unirradiated cells near far irradiation site control tumor response nevertheless previous studies address problem global context present gaps regarding link role immune system control nontargeted effects different types radiotherapy different fractionation schemes applied gbm narrative synthesis scientific literature help update critique available preclinical medical knowledge indirectly help formulate new research projects based synthesis interpretation results nonsystematic selection published studies