Panagiota Kyratzi, Oswald Matika, Amey H Brassington, Clare E Connie, Juan Xu, David A Barrett, Richard D Emes, Alan L Archibald, Andras Paldi, Kevin D Sinclair, Jonathan Wattis, Cyril Rauch
Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping
bioRxiv : the preprint server for biology
united states discrepancy organ availability need persisted despite changes allocation innovations preservation policy initiatives living donor liver transplant ldlt remains underutilized means improving access timely liver transplantation decreasing waitlist mortality liver paired exchange lpe represents opportunity overcome ldlt pair incompatibility due size anatomy blood type lpe adopted strategy augment access liver transplantation institution specific educational materials consent forms selection processes developed facilitate lpe 2019 october 2023 center performed 11 lpes resulting 23 ldlt pairs series included several types lpe combining complementary incompatible pairs inclusion compatible pairs overcome incompatibility use altruistic nondirected donors initiate chains exchanges facilitated transplantation 23 recipients including 1 pediatric patient lpe improved access liver transplantation institution ethical application lpe includes tailored patient education assessment disclosure exchange balance mitigation risk maximization benefit donors recipients