Sabrina Mousum, Marium Salwa, Khandakar Fatema, Md Atiqul Haque
Psychometric Validation of the Translated and Adapted Bengali Version of the HLS-EU-Q16/Q6 for Adults
Inquiry : a journal of medical care organization, provision and financing
air pollution exposure one modifiable risk factors cognitive decline aimed test association exposure several outdoor air pollutants domainspecific cognitive performance crosssectional study used data enrolment phase french constances cohort 220 000 people aged 1869 years randomly recruited french constances cohort participants aged 45 years old older 104 733 people underwent comprehensive cognitive assessment verbal episodic memory language skills executive functions exclusion suitable analysis 61 462 participants available data included analyses used annual mean concentrations residential addresses derived landuse regression models assign exposure particulate matter aerodynamic diameters less 25 pm25 nitrogen dioxide no2 black carbon used multiple linear regression models different covariate adjustments test associations pollutant cognitive outcomes several sensitivity analyses including multilevel modelling metaanalysis centre recruitment exclusion specific population groups found significantly poorer cognitive function especially semantic fluency domains executive functions increase exposure black carbon no2 exposure pm25 mainly significant semantic fluency test found decrease cognitive performance increase one interquartile range exposure ranged 1 nearly 5 largest effect size percentage decrease pm25 no2 found semantic fluency test pm25 46 95 ci 2169 no2 38 1957 whereas black carbon largest effect size found digit symbol substitution test domains executive functions 45 2763 monotonic linear exposureresponse associations found air pollution exposure cognitive performance starting low level exposures significantly poorer cognitive performance associated exposure outdoor air pollution even low levels exposure highlights importance efforts reduce exposure air pollution caisse nationale dassurance maladie partly funded merck sharp dohme loral french national research agency fondation de france french translation abstract see supplementary materials section