Mingsheng Liao, Zhiquan Xie, Qiyun Ou, Lifang Yang, Liqin Zou
Self-efficacy mediates the effect of professional identity on learning engagement for nursing students in higher vocational colleges: A cross-sectional study
Nurse education today
objective hypoglycaemia redefining solutions better lives hyporesolve project use dataset pooled clinical trials across pharmaceutical device companies people type 1 type 2 diabetes examine factors associated incident hypoglycaemia events quantify prediction events data 90 trials 46254 participants pooled analyses done type 1 type 2 diabetes separately poisson mixed models adjusted age sex diabetes duration trial identifier fitted assess association clinical variables hypoglycaemia event counts treebased gradientboosting algorithms xgboost fitted using training data predictive performance terms area receiver operating characteristic curve auc evaluated test data baseline models including age sex diabetes duration compared models included score hypoglycaemia first 6 weeks study entry full models included clinical variables relative predictive importance covariate assessed using xgboosts importance procedure prediction across entire trial duration trial mean 348 weeks type 1 diabetes 253 weeks type 2 diabetes assessed type 1 type 2 diabetes variables associated frequent hypoglycaemia included female sex white ethnicity longer diabetes duration treatment human opposed analogueonly insulin higher glucose variability higher score hypoglycaemia across 6 week baseline period lower bp lower lipid levels treatment psychoactive drugs prediction hypoglycaemia event severity greater prediction hypoglycaemia requiring assistance level 3 hypoglycaemia events sparser prediction level 1 worse hypoglycaemia whole followup period auc 0835 95 ci 0826 0844 type 1 diabetes 0840 95 ci 0831 0848 type 2 diabetes level 3 hypoglycaemia auc lower 0689 95 ci 0667 0712 type 1 diabetes 0705 95 ci 0662 0748 type 2 diabetes compared baseline models almost improvement prediction could captured individuals hypoglycaemia history glucose variability blood glucose 6 week baseline period although hypoglycaemia rates show large variation according sociodemographic clinical characteristics treatment history looking 6 week period hypoglycaemia events glucose measurements predicts future hypoglycaemia risk