Astrid Torbjørnsen, Ingeborg Spildo, Maria Aadland Mollestad, Annesofie Lunde Jensen, Tone Singstad, Nina Mickelson Weldingh, Pål Joranger, Lis Ribu, Heidi Holmen
Investigating Digital Patient-Reported Outcome Measures in Patient-Centered Diabetes Specialist Outpatient Care (DigiDiaS): Protocol for a Multimethod Prospective Observational Study
JMIR research protocols
cognitive deficits core characteristics schizophrenia presenting emergence psychotic symptoms individuals clinical highrisk psychosis chr genetically highrisk psychosis ghr also exhibit cognitive impairments nonetheless remains uncertain domains cognitive impairments two groups similar schizophrenia patients moreover unclear domains impairment caused quality factors related state disease research initiative aimed extensively examine distinct cognitive impairment profiles among chr ghr firstepisode schizophrenia fes cohorts compared cognitive functions three groups healthy control group hcs using matrics consensus cognitive battery mccb participants study recruited beijing anding hospital capital medical university sample consisted 56 patients fes 42 chr 26 ghr 62 hcs participants across groups matched terms gender age level education individuals fes ghr chr showed significant impairment across majority mccb domains exception visual learning comparison hcs none mccb domains demonstrated discerning ability accurately differentiate individuals chr ghr speed processing attentionvigilance domains individuals ghr chr exhibited scores fes hcs group differences reaching statistical significance pattern results indicates intermediate level cognitive function individuals ghr chr conversely levels impairment observed working memory verbal learning relatively consistent across three groups fes chr ghr notably individuals chr group exhibited performance akin hcs reasoningproblemsolving domain showing significant differences fes group chr individuals demonstrating better performance additionally individuals ghr displayed performance social cognition similar hcs also demonstrating significant distinctions fes group ghr individuals demonstrating better performance significant cognitive deficits exist individuals chr ghr fes deficits vary across domains processing speed attentionvigilance could potentially serve robust biomarkers identifying individuals risk psychosis impairment observed reasoningproblemsolving abilities might signify qualitative trait whereas deficits social recognition could indicate state characteristic specific schizophrenia