Mesfin Dessale, Getachew Mengistu, Hylemariam Mihiretie Mengist
Prevalence, antimicrobial resistance pattern, and associated factors of Salmonella and Shigella among under five diarrheic children attending public health facilities in Debre Markos town, Northwest Ethiopia
Frontiers in public health
rdf triple provides simple linguistic means describing limitless types information triples flexibly combined unified data source call semantic model semantic models open new possibilities integration variegated biological data use semantic web technology explicate high throughput clinical data context fundamental biological knowledge extended corvus data warehouse provides uniform interface various forms omics data providing sparql endpoint querying reasoning tools made possible semantic web able explore quantitative semantic models retrieved corvus light systematic biological knowledge paper merged semantic models containing genomic transcriptomic epigenomic data melanoma samples two semantic models functional data one containing gene ontology go data regulatory networks constructed transcription factor binding information two semantic models created ad hoc manner support common interface integration quantitative semantic models combined semantic models allow us pose significant translational medicine questions study interplay cells molecular state response anticancer therapy exploring resistance cancer cells decitabine demethylating agent able generate testable hypothesis explain decitabine fights cancer namely targets apoptosisrelated gene promoters predominantly decitabinesensitive cell lines thus conveying cytotoxic effect activating apoptosis pathway research provides framework whereby similar hypotheses developed easily