Aurore Curie, Amandine Brun, Anne Cheylus, Anne Reboul, Tatjana Nazir, Gérald Bussy, Karine Delange, Yves Paulignan, Sandra Mercier, Albert David, Stéphanie Marignier, Lydie Merle, Bénédicte de Fréminville, Fabienne Prieur, Michel Till, Isabelle Mortemousque, Annick Toutain, Eric Bieth, Renaud Touraine, Damien Sanlaville, Jamel Chelly, Jian Kong, Daniel Ott, Behrouz Kassai, Nouchine Hadjikhani, Randy L Gollub, Vincent des Portes
A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients
PloS one
invasive fungal infection ifi become increasing problem nicu neonates endorgan damage eod ifi one leading causes morbidity mortality neonates study conducted summarize clinical data epidemiology risk factors causative pathogens clinical outcomes ifiassociated eod among neonates center china sake providing references prevention treatment fungal infections neonates future clinical data ifi neonates received treatment tertiary nicu china january 2009 december 2022 retrospectively analyzed including causative pathogens incidence eod neonates divided eod group noneod neod group general characteristics risk factors clinical outcomes two groups compared included study 223 ifi neonates 137 male 86 female median gestational age ga 3071 2935 weeks median birth weight bw 1470 11202150 g 794 preterm infants 502 born ga 28 32 weeks 377 bw 10001499 g candida albicans c albicans common candida spp neonates accounting 413 cases followed c parapsilosis 305 c glabrata 72 eod occurred 40 179 223 cases fungal meningitis common eod accounting 135 40 eod cases significant difference premature birth rate delivery mode ga bw eod neod groups proportion male infants eod higher without significant difference antenatal corticosteroid use endotracheal intubation invasive procedures use antibiotics total parenteral nutrition blood transfusion postnatal corticosteroid use fungal prophylaxis incidence necrotizing enterocolitis two groups proportion c albicans infection cases eod group higher neod group 575 vs 377 compared neod group proportion cured improved infants eod group significantly lower p 005 number infants died withdrew treatment larger p 005 retrospective study showed preterm infants prone fungal infection especially preterm infants c albicans common candida spp ifi highrisk factor eod eod occur fullterm premature infants possibility eod considered infants ifi