Yining Pan, Ashley Ballard, Beomyoung Cho
Sex and Racial/Ethnic Patterns of Tobacco Product Use Among Students at a U.S. University in 2021-2023
Substance use & misuse
bacteraemia critical condition generally leads substantial morbidity mortality unclear whether delayed antimicrobial therapy andor source control prognostic defervescence effect patients sourcecontrolrequired scr unrequired scu bacteraemia multicenter cohort included treatmentnave adults bacteraemia emergency department clinical information retrospectively obtained etiologic pathogens prospectively restored accurately determine timetoappropriate antibiotic ttaa association ttaa timetosource control ttsc scr bacteraemia 30day crude mortality delayed defervescence respectively studied adjusting independent determinants mortality delayed defervescence recognised logistic regression model total 5477 patients hour ttaa delay associated average increase 02 adjusted odds ratio aor 1002 p 0001 03 aor 1003 p 0001 mortality rates patients scu 3953 patients scr 1524 bacteraemia respectively notably aors augmented 04 05 critically ill individuals patients experiencing scr bacteraemia hour ttsc delay significantly associated average increase 031 033 mortality rates overall critically ill individuals respectively febrile patients additional hour ttaa significantly associated average 02 03 increase proportion delayed defervescence scu 3085 patients scr 1266 bacteraemia respectively 05 09 critically ill individuals 1266 febrile patients scr bacteraemia hour ttsc delay respectively significantly associated average increase 03 04 mortality rates overall population critical illness regardless need source control cases bacteraemia seems significant association prompt administration appropriate antimicrobials favourable prognosis rapid defervescence particularly among critically ill patients scr bacteraemia delayed source control identified determinant unfavourable prognosis delayed defervescence moreover association patient survival speed defervescence appears augmented among critically ill patients