Eduardo Faerstein, Dóra Chor, Guilherme Loureiro Werneck, Claudia de Souza Lopes, George Kaplan
Race and perceived racism, education, and hypertension among Brazilian civil servants: the Pró-Saúde Study
Revista brasileira de epidemiologia = Brazilian journal of epidemiology
single nucleotide polymorphisms snps may influence pain susceptibility impact treatment response painrelated temporomandibular disorders tmdp explore role comt rs4646310 rs6269 rs4818 rs4680 oprm1 rs1799971 genotypes regulating treatment response sixty tmdp patients 55 females 5 males diagnosed diagnostic criteria tmd dctmd underwent standardised treatment information education home physical therapy occlusal splint 6 months treatment outcomes included pain intensity painfree mouth opening jaw functional limitation depression anxiety genotyping comt oprm1 snps performed using dna buccal mucosa swabs taqman assays statistical analysis carried compare changes treatment outcomes influence genotypes treatment response significantly less pain reduction observed minor allele carriers rs4646310 rs4680 compared dominant homozygous p 025 minor allele carriers rs1799971 rs4646310 demonstrated worsening painfree mouth opening dominant homozygous exhibited improvement p 025 significantly less anxiety reduction observed minor allele carriers rs4646310 compared dominant homozygous p 003 variables assessed regression model carrying minor allele rs1799971 predicted poorer treatment response considering painfree mouth opening carrying minor allele rs4646310 predicted less pain less anxiety reduction findings indicate certain snp variants comt oprm1 genes associated poorer treatment response may therefore play significant role classification tmdp patients also assessment patient genotype could potentially aid predicting treatment response