Juliana Dos Santos Müller, Ila Rocha Falcão, Maria Carolina Barreto Moreira Couto, Wendel da Silva Viana, Ivone Batista Alves, Denise Nunes Viola, Courtney Georgette Woods, Rita Franco Rêgo
Health-Related Quality of Life among Artisanal Fisherwomen/Shellfish Gatherers: Lower than the General Population
International journal of environmental research and public health
introduce chalkboard prototype tool representing displaying cellsignaling pathway knowledge carrying simple qualitative reasoning pathways generating quantitative biosimulation code design chalkboard driven need quickly model visualize alternative hypotheses uncertain pathway knowledge chalkboard allows biologists test silico implications various hypotheses fulfill need chalkboard includes 1 rich ontology pathway entities interactions ultimately informed basic chemistry physics among molecules 2 form qualitative reasoning computes causal chains feedback loops within network entities reactions demonstrate chalkboards capabilities domain app proteolysis pathway plays key role pathogenesis alzheimers disease pathway common information incomplete parts pathways conjectural rather experimentally verified chalkboard carry silico perturbation experiments explore consequences different conjectural connections relationships network believe pathway reasoning capabilities silico experiments become critical component hypothesis generation phase modern biological research