Yingying Wang|Meaghan V. Mauer|Talia Raney|Barbara Peysakhovich|Bryce L. C. Becker|Danielle D. Sliva|Nadine Gaab
Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls
Harvard University|University of Nebraska–Lincoln|Boston Children's Hospital|Boston Children's Hospital|Boston Children's Hospital|Boston Children's Hospital|Boston Children's Hospital|Boston Children's Hospital|Harvard University|Boston Children's Hospital
developmental dyslexia neurodevelopmental disorder strong genetic basis previous studies observed white matter alterations left posterior brain regions adults schoolage children dyslexia however study yet examined development tractspecific white matter pathways prereading fluent reading stage children familial risk dyslexia fhd versus controls fhd study examined white matter integrity prereading beginning fluent reading stages crosssectionally n 78 longitudinally n 45 using automated fibertract quantification method findings depict white matter alterations atypical lateralization arcuate fasciculus prereading stage fhd versus fhd children moreover demonstrate faster white matter development subsequent good versus poor readers positive association white matter maturation reading development using longitudinal design additionally combination white matter maturation familial risk psychometric measures best predicted later reading abilities furthermore within fhd children subsequent good readers exhibited faster white matter development right superior longitudinal fasciculus compared subsequent poor readers suggesting compensatory mechanism overall findings highlight importance white matter pathway maturation development typical atypical reading skills