Deanna Alexis Carere|Peter Kraft|Kimberly A. Kaphingst|J. Scott Roberts|Robert Green
Consumers report lower confidence in their genetics knowledge following direct-to-consumer personal genomic testing
Brigham and Women's Hospital|Huntsman Cancer Institute|University of Utah|University of Michigan–Ann Arbor|Michigan Department of Health and Human Services|Mass General Brigham|Harvard University|Brigham and Women's Hospital
aim study measure changes genetics knowledge selfefficacy following personal genomic testing pgtnew customers 23andme pathway genomics completed series online surveys measured genetics knowledge nine truefalse items genetics selfefficacy five likertscale items receipt results 6 months results used paired methods evaluate change time correlates change eg decision regret identified using linear regression998 pgt customers 599 female 858 white mean age 469 155 years included analyses mean genetics knowledge score 815 095 9 baseline 825 092 6 months p 00024 mean selfefficacy score 2906 559 35 baseline 277 546 6 months p 00001 item 3045 participants reported lower selfefficacy following pgt change selfefficacy positively associated healthcare provider consultation p 00042 impact pgt perceived control ones health p 00001 perceived value pgt p 00001 negatively associated decision regret p 00001lowered genetics selfefficacy following pgt may reflect appropriate reevaluation consumers response receiving complex genetic informationgenet med 18 1 6572