Juntaro Matsuzaki|Hidekazu Suzuki|Keiko Asakura|Yasushi Fukushima|John M. Inadomi|Toru Takebayashi|Toshifumi Hibi?
Classification of functional dyspepsia based on concomitant bowel symptoms
Keio University|Keio University|Keio University|University of Washington|Keio University|Keio University
abstract background functional dyspepsia fd heterogeneous disease categorized postprandial distress syndrome pds epigastric pain syndrome eps however many fd patients overlap pds eps present study designed examine whether fd could categorized based presence concomitant gastrointestinal symptoms methods web survey comprised gastrointestinal symptom rating scale gsrs rome iii criteria fd demographic information sent public participants history severe illness factor cluster analyses conducted identify subcategories fd based gsrs key results total 8038 participants completed survey total 563 participants met criteria fd whereas 6635 participants dyspepsia symptoms remainder either organic disease 377 uninvestigated dyspepsia 463 cluster analysis categorized participants constipation predominant cluster c diarrhea predominant cluster neither diarrhea constipation cluster ncnd cluster c significantly associated presence fd odds ratio 257 95 confidence interval ci 206321 280 95 ci 227345 respectively fd especially pds cases scores upper gastrointestinal symptoms higher cluster c cluster ncnd conclusions amp inferences severity dyspepsia symptoms associated presence bowel symptoms especially pds novel categorization fd based concomitant constipation diarrhea may improve classification patients