Jonathan D. Rohrer|Dominic Paviour|Adolfo M. Bronstein|Sean S. O’Sullivan|Andrew J. Lees|Jason D. Warren
Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: A neuropsychological and neuroimaging analysis
UK Dementia Research Institute|University College London|University College London|UK Dementia Research Institute|Charing Cross Hospital|Imperial College London|University College London|University College London|UK Dementia Research Institute|University College London
currently considerable interest clinical spectrum progressive nonfluent aphasia pnfa progressive supranuclear palsy psp intersection two entities undertook detailed prospective clinical neuropsychological neuroimaging analysis 14 consecutive patients presenting pnfa identify cases meeting clinical criteria psp patients detailed assessment extrapyramidal oculomotor functions patients highresolution mr brain volumetry cortical thickness analysis undertaken brain images four patients presenting pnfa subsequently developed features psp syndrome including typical oculomotor palsy neuropsychological profile cases similar patients pnfa however marked reduction propositional speech fewer speech errors less marked impairment literacy skills severe associated deficits episodic memory praxis psppnfa cases less prominent midbrain atrophy marked prefrontal atrophy comparison group five patients pathologically confirmed psp without pnfa prominent midbrain atrophy less marked perisylvian atrophy pnfa cases summary although psppnfa syndrome overlaps pnfa without psp certain neuropsychological neuroanatomical differences may help predict development psp syndrome