Christopher Leonetti|Craig M. Butt|Kate Hoffman|Marie Lynn Miranda|Heather M. Stapleton
Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
Duke University|Duke University|Duke University|Duke University|Rice University|Duke University
legacy environmental contaminants polybrominated diphenyl ethers pbdes widely detected human tissues however studies measured pbdes placental tissues reported measurements 246tribromophenol 246tbp placental tissues measurements contaminants important understanding potential fetal exposures compounds shown alter thyroid hormone regulation vitro vivo study measured suite pbdes 246tbp 102 human placental tissues collected 2010 2011 durham county north carolina usa abundant pbde congener detected bde47 mean concentration 509ngg lipid range 012141ngg lipid detection frequency 91 however 246tbp ubiquitously detected present higher concentrations mean concentration 154ngg lipid range131316ngg lipid detection frequency 100 bde209 also detected 50 samples significantly associated 246tbp placental tissues suggesting may similar source 246tbp may degradation product bde209 interestingly bde209 246tbp negatively associated age rs016 p010 rs017 p008 respectively results work indicate pbdes 246tbp bioaccumulate human placenta tissue likely contribute prenatal exposures environmental contaminants future studies needed determine joint exposures associated adverse health measures infants children