Guobin Zhao, Yongchul G Chung
PACMAN: A Robust Partial Atomic Charge Predicter for Nanoporous Materials Based on Crystal Graph Convolution Networks
Journal of chemical theory and computation
seems general agreement prevalence obesity increasing united states midst obesity epidemic diseaserelated implications epidemic received enormous amount publicity popular media public awareness untoward effects excess weight led effective approach dealing dilemma gravity problem accentuated light report approximately 50 physicians polled provided weight loss counseling given importance excess adiposity increasing risk cvd 2dm hypertension combination increase prevalence overweightobesity health care system unprepared deal situation essential considerable thought given best address dilemma context must emphasized cvd 2dm hypertension characterized resistance insulinmediated glucose disposal insulin resistance compensatory hyperinsulinemia associated insulin resistance shown independent predictors three clinical syndromes also apparent many years overweightobese individuals tend insulin resistant become insulin sensitive weight loss25 light observations seems reasonable suggest insulin resistance link overweightobesity adverse clinical syndromes related excess adiposity evidence summarized review shows overweight individual likely insulin resistant increased risk develop abnormalities associated defect insulin action overweightobese individuals insulin resistant however insulin resistant individuals overweightobese important compelling evidence cvd risk factors present significantly greater degree subset overweightobese individuals also insulin resistant surprisinglywe also demonstrated improvement cvd risk factors weight loss occurs significantly greater degree overweightobese individuals also insulin resistant baseline view ineffectiveness current clinical approaches weight loss seems necessary recognize overweightobese individuals equal risk develop cvd clinically useful identify highest risk simplest way achieve task seems focusing cvd risk factors highly associated insulin resistancehyperinsulinemia done intense efforts weight control brought bear need also gain losing weight