Kristine Yaffe
Association of Plasma ?-Amyloid Level and Cognitive Reserve With Subsequent Cognitive Decline
Jacksonville College|Mayo Clinic in Florida|Winneshiek Medical Center|National Institute on Aging|University of Tennessee at Knoxville|Pittsburg State University|University of Pittsburgh|Wake Forest University|University Medical Center|University of California, San Francisco
lower plasma amyloid 42 4240 levels associated incident dementia results conflicting investigated cognitive decline among elders without dementiato determine plasma amyloid associated cognitive decline association modified measures cognitive reservewe studied 997 black white communitydwelling older adults memphis tennessee pittsburgh pennsylvania enrolled health abc study prospective observational study begun 19971998 10year followup 20062007 participant mean age 740 sd 30 years 552 n 550 female 540 n 538 blackassociation nearbaseline plasma amyloid levels 42 4240 measured 2010 repeatedly measured modified minimental state examination 3ms resultslow amyloid 4240 level associated greater 9year 3ms cognitive decline lowest amyloid tertile mean change 3ms score 659 95 confidence interval ci 521 767 points middle tertile 616 95 ci 492 732 points highest tertile 360 95 ci 227 473 points p 001 results similar multivariate adjustment age race education diabetes smoking apolipoprotein e apoe e4 status excluding 72 participants incident dementia measures cognitive reserve modified association whereby among high reserve least high school diploma higher sixthgrade literacy apoe e4 allele amyloid 4240 less associated multivariate adjusted 9year decline example among participants less high school diploma 3ms score decline 894 95 ci 694 1094 lowest tertile compared 445 95 ci 231 659 highest tertile least high school diploma 3ms score decline 460 95 ci307 613 lowest tertile 288 95 ci141 435 highest tertile p 004 interaction interactions also observed literacy p 005 apoe e4 allele p 02lower plasma amyloid 4240 associated greater cognitive decline among elderly persons without dementia 9 years association stronger among low measures cognitive reserve