Justin J Choi, Lars G Osterberg, Janet D Record
Exploring Ward Team Handoffs of Overnight Admissions: Key Lessons from Field Observations
Journal of general internal medicine
effort expedite publication articles ajhp posting manuscripts online soon possible acceptance accepted manuscripts peerreviewed copyedited posted online technical formatting author proofing manuscripts final version record replaced final article formatted per ajhp style proofed authors later time familiarize clinicians emerging concepts critical care research bayesian thinking personalized medicine phenotyping explain clinical relevance highlighting address issues frequent negative trials heterogeneity treatment effect past decades seen many negative effectneutral critical care trials promising interventions culminating calls improve fields research adopting bayesian thinking increasing personalization critical care medicine phenotyping bayesian analyses add interpretive power clinicians summarize treatment effects based probabilities benefit harm contrasting conventional frequentist statistics either affirm reject null hypothesis critical care trials beginning include prospective bayesian analyses many trials undergone reanalysis bayesian methods phenotyping seeks identify treatable traits target interventions patients expected derive benefit phenotyping subphenotyping gained prominence syndromic heterogenous critical care disease states acute respiratory distress syndrome sepsis grouping patients informative across spectrum clinically observable physiological parameters biomarkers genomic data bayesian thinking phenotyping emerging elements adaptive clinical trials predictive enrichment paving way new era highquality evidence concepts share common goal sifting noise heterogeneity critical care increase value existing future research future critical care medicine inevitably involve modification statistical methods bayesian analyses targeted therapeutics via phenotyping clinicians must familiar systems support recommendations improve decisionmaking gray areas critical care practice