Jung Guel Kim, Sang-Min Park, Ho-Joong Kim, Jin S Yeom
Development and Validation of a Risk-Prediction Nomogram for Chronic Low Back Pain Using a National Health Examination Survey: A Cross-Sectional Study
Healthcare (Basel, Switzerland)
acuteonchronic liver failure aclf major public health concern aimed assess definitions etiological spectrum organ failure outcomes aclf globally three databases searched studies aclf 1990 till september 2022 information regarding definitions acute precipitants underlying chronic liver disease cld mortality extracted metaanalyses performed pooled prevalence rates 95 confidence interval ci using random effects model definition aclf 11451 studies identified 114 articles 142 cohorts encompassing 210239 patients met eligibility criteria studies 532 used european association study liver easl definition followed asiapacific association study liver apasl 333 systemic infection major acute precipitant alcohol use major cause cld easldefined studies alcohol major acute precipitant cause cld apasldefined studies liver failure major apaslbased studies renal failure predominant easlbased studies thirtyday mortality varied across definitions apasl 389 95ci 312469 easl 479 95ci 422535 nacseld 522 95ci 519525 diagnostic overlap definitions ranged 77 802 metaregression suggested region influenced 30day mortality studies using easl definition heterogeneity definition aclf proposed different expert societies regional preferences use result differences clinical phenotype outcomes uniform definition would enhance comparability interpretation global data