Zhuo Zhang, Jie Li, Yansheng Chen, Fajun Chen, Zhonghao Liu
Mapping the educational Frontier: Unleashing the Potential of artificial intelligence talents through cooperative planning in the Guangdong-Hong Kong-Macao greater bay area
Heliyon
study aimed investigate role uric acid ua diabetic nephropathy dn epidemiological genetic perspectives used data 20072016 national health nutrition examination survey evaluate relationship ua dn risk using weighted multivariateadjusted logistic regression subsequently twosample mendelian randomization study conducted using genomewide association study summary statistics main inverse variance weighting ivw method supplementary mr method used verify causal relationship ua dn sensitivity analysis conducted confirm credibility results observational study enrolled 4363 participants diabetes mellitus nhanes among 2682 614 participants identified dn multivariate logistic regression model showed compared without hyperuricemia dn risk hyperuricemia population significantly increased p 005 mr results suggest direct causal effect hyperuricemia dn ivw odds ratio 137 95 confidence interval 107176 p 001 consistent findings mr methods evidence observational studies indicates positive correlation hua onset dn causal effects hua dn supported mr analysis