Paolo Pellizzoni, Giulia Muzio, Karsten Borgwardt
Higher-order genetic interaction discovery with network-based biological priors
Bioinformatics (Oxford, England)
mean body weight gradually increases age yet little data exists prevalence excess weight populations aged 80 years older moreover little known predictors overweight obesity old age thus purpose study present data prevalence excess weight old age germany investigate predictors excess weight crosssectional approach examine factors affecting excess weight longitudinal approach subjects consisted 1882 individuals aged 79 years older course excess weight observed 3 years excess weight defined follows overweight 25 kgm2 bmi 30 kgm2 obesity bmi 30 kgm2 used fixed effects regressions estimate effects time dependent variables bmi overweight obesity respectively majority overweight 400 obese 137 crosssectional regressions revealed bmi positively associated younger age severe walking impairments negatively associated cognitive impairments excess weight positively associated younger age elementary education walking impairments physical inactivity excess weight negatively associated cognitive impairment longitudinal regressions showed age severely impaired walking disabilities reduced bmi probability transitions excess weight decreased considerably older age occurrence severe walking impairments overweight marked differences predictors cross longitudinal setting exist underlining complex nature excess weight old age