Neuza Maria Alcântara?Neves|Samuel J Badaró|Mariese Conceição Alves dos Santos|Lain Carlos Pontes?de?Carvalho|Maurício L. Barreto
The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children
Universidade Federal da Bahia|Universidade Federal da Bahia|Universidade Federal da Bahia|Fundação Oswaldo Cruz|Universidade Federal da Bahia|Instituto de Saúde
elucidation factors trigger development transient wheezing early childhood may important step toward understanding pathogenesis asthma allergic diseases later life transient wheezing mainly attributed viral infections although sensitisation aeroallergens food allergens may occur early age developing countries intestinal helminthic infections also associated allergy atopyrelated disordersthe aim study explore association trichuris trichiura ascaris lumbricoides infections wheezing atopy early childhooda crosssectional study using portugueselanguage isaac phase questionnaire adapted preschoolaged children nested cohort study childhood diarrhoea conducted 682 children two faecal samples per child examined presence intestinal helminthic infection ige antibodies three allergenic preparations dermatophagoides pteronyssinus blomia tropicalis common child food well lumbricoides antigens measured subsample children whose parents allowed procedure atopy defined presence levels serum ige antibodies 035 kul least one three tested allergenic preparationsactive trichiura infection lumbricoides infection positively associated wheezing total studied children population adjusted 260 ci 154438 atopic children subpopulation adjusted 307 ci 100943 association atopy also positive statistically significant brute analysis 213 ci 103440 antia lumbricoides ige antibodies current lumbricoides infection positively associated wheezing atopic children adjusted 201 ci 100450 nonatopic children adjusted 307 ci 113835 also associated atopy adjusted 729 ci 390 134 hands reports wheezing significantly associated atopythese data corroborate previous studies showing wheezing predominantly associated infection early childhood shows antia lumbricoides ige antibodies active ascaris infections associated wheezing atopy additionally data demonstrate trichiura infection may play role pathogenesis atopic wheezing early childhood