Ning Li, Jincai Huang, Yanghe Feng
Construction and confirmatory factor analysis of the core cognitive ability index system of ship C2 system operators
PloS one
integrative analysis multiomics data potential yield valuable comprehensive insights molecular mechanisms underlying complex diseases cancer alzheimers disease however number analytical challenges complicate multiomics data integration instance omics data usually highdimensional sample sizes multiomics studies tend modest furthermore genes important pathway relatively weak signal difficult detect individually growing body literature knowledgeguided learning methods address challenges incorporating biological knowledge functional genomics functional proteomics multiomics data analysis methods shown outperform counterparts utilize biological knowledge tasks including prediction feature selection clustering dimension reduction review survey recently developed methods applications knowledgeguided multiomics data integration methods discuss future research directions