Dmitry Efrosinin, Vladimir Vishnevsky, Natalia Stepanova
Optimal Scheduling in General Multi-Queue System by Combining Simulation and Neural Network Techniques
Sensors (Basel, Switzerland)
longitudinal clinical trials recurrent events endpoints interest commonly subject missing event data primary analyses trials often performed assuming events missing random sensitivity analyses necessary assess robustness primary analysis conclusions missing data assumptions controlbased imputation attractive approach superiority trials imposing conservative assumptions data may missing random popular approach implementing controlbased assumptions recurrent events multiple imputation mi rubins variance estimator often biased true sampling variability point estimator controlbased setting propose distributional imputation di corresponding wild bootstrap variance estimation procedure controlbased sensitivity analyses recurrent events apply controlbased di type diabetes trial application simulation studies di produced reasonable standard error estimates mi rubins combining rules controlbased sensitivity analyses recurrent events