Michele B. Parsons|Dominic A. Travis|Elizabeth V. Lonsdorf|Iddi Lipende|Dawn M. Roellig|Shadrack Kamenya|Hongwei Zhang|Lihua Xiao|Thomas R. Gillespie
Epidemiology and Molecular Characterization of Cryptosporidium spp. in Humans, Wild Primates, and Domesticated Animals in the Greater Gombe Ecosystem, Tanzania
Emory University|Waterborne Environmental (United States)|Centers for Disease Control and Prevention|University of Minnesota|Franklin & Marshall College|The Jane Goodall Institute|The Jane Goodall Institute|Waterborne Environmental (United States)|Centers for Disease Control and Prevention|The Jane Goodall Institute|Henan Provincial Center for Disease Control and Prevention|Waterborne Environmental (United States)|Centers for Disease Control and Prevention|Emory University
cryptosporidium important zoonotic parasite globally studies examined ecology epidemiology pathogen rural tropical systems characterized high rates overlap among humans domesticated animals wildlife investigated risk factors cryptosporidium infection assessed crossspecies transmission potential among people nonhuman primates domestic animals gombe ecosystem kigoma district tanzania crosssectional survey designed determine occurrence risk factors cryptosporidium infection humans domestic animals wildlife living around gombe national park diagnostic pcr revealed cryptosporidium infection rates 43 humans 160 nonhuman primates 96 livestock local streams sampled negative dna sequencing uncovered complex epidemiology cryptosporidium system humans baboons subset chimpanzees infected c hominis subtype ifa12g2 another subset chimpanzees infected c suis positive goats sheep infected c xiaoi humans residence location associated increased risk infection mwamgongo village compared one camp kasekela increased odds infection living household another positive person fecal consistency gastrointestinal signs predict cryptosporidium infection despite high degree habitat overlap village people livestock results suggest distinct cryptosporidium transmission dynamics humans livestock system dominance c hominis subtype ifa12g2 among humans nonhuman primates suggest crossspecies transmission interestingly subset chimpanzees infected c suis hypothesize crossspecies transmission bush pigs potaochoerus larvatus chimpanzees gombe forest since domesticated pigs regionally absent findings demonstrate complex nature cryptosporidium sympatric primates including humans stress need studies