Clément Guibert|Camille Maumet|Pierre Jannin|Jean?Christophe Ferré|C. Tréguier|Christian Barillot|Élisabeth Le Rumeur|Catherine Allaire|Arnaud Biraben
Abnormal functional lateralization and activity of language brain areas in typical specific language impairment (developmental dysphasia)
French Institute for Research in Computer Science and Automation|University of Rennes|Institut de Recherche en Informatique et Systèmes Aléatoires|French National Centre for Scientific Research|Inserm|French Institute for Research in Computer Science and Automation|University of Rennes|Institut de Recherche en Informatique et Systèmes Aléatoires|French National Centre for Scientific Research|Inserm|French Institute for Research in Computer Science and Automation|University of Rennes|Institut de Recherche en Informatique et Systèmes Aléatoires|French National Centre for Scientific Research|Inserm|French Institute for Research in Computer Science and Automation|Hôpital Pontchaillou|University of Rennes|Institut de Recherche en Informatique et Systèmes Aléatoires|French National Centre for Scientific Research|Inserm|Hôpital Pontchaillou|French Institute for Research in Computer Science and Automation|University of Rennes|Institut de Recherche en Informatique et Systèmes Aléatoires|French National Centre for Scientific Research|Inserm|Hôpital Pontchaillou|Hôpital Pontchaillou
atypical functional lateralization specialization language proposed account developmental language disorders yet results functional neuroimaging studies sparse inconsistent functional magnetic resonance imaging study compared children specific subtype specific language impairment affecting structural language n 21 matched group typically developing children using panel four language tasks neither requiring reading metalinguistic skills including two auditory lexicosemantic tasks category fluency responsive naming two visual phonological tasks based picture naming data processing involved normalizing data respect matched pairs paediatric template groups betweengroups analysis laterality indices assessment within regions interest using single combined task analysis children specific language impairment exhibited significant lack left lateralization core language regions inferior frontal gyrusopercularis inferior frontal gyrustriangularis supramarginal gyrus superior temporal gyrus across single combined task analysis difference lateralization rest brain betweengroup comparisons revealed left hypoactivation wernickes area posterior superior temporalsupramarginal junction responsive naming task right hyperactivation encompassing anterior insula adjacent inferior frontal gyrus head caudate nucleus first phonological task study thus provides evidence subtype specific language impairment associated atypical lateralization functioning core language areas