Daniela Mazzuca, Fulvio Bergantin, Davide Macrì, Francesco Zinno, Agostino Forestiero
AI Approach for Enhanced Thalassemia Diagnosis Using Blood Smear Images
Studies in health technology and informatics
evidencebased interventions protect cognitive decline among older adults risk alzheimers disease related dementias adrd urgently needed rehabilitation approaches support memory behaviorallifestyle interventions recognized promising strategies preserving improving cognitive health although previous interventions combined approaches paper describes protocol brain boosters intervention synergistically combines training compensatory healthy lifestyle behaviors supports implementation tracking new behaviors digital application study utilizes singlesite singleblinded randomized controlled design compare structured lifestyle compensatory aid intervention educationonly selfguided intervention plan enroll 225 communitydwelling adults 25 underrepresented groups aged 65 endorse subjective cognitive decline scd low baseline levels healthy lifestyle behaviors interventions administered group format consisting 15 twohour classes occur weekly ten weeks taper bimonthly monthly intervention duration 6 months participants interventions receive education variety memory support strategies healthy lifestyle behaviors focusing physical cognitive activity stress management structured intervention also receive support adopting new behaviors tracking set goals aided electronic memory management aid emma digital application primary outcomes include global cognition composite memory attention executive function tests everyday function everyday cognition questionnaire data collected baseline outcome visits approximately 6 12 18 months qualitative interviews selfreport surveys eg indicators selfdetermination health literacy emma data metrics also used identify components intervention effective work successful project completion provide valuable information individuals scd respond compensation preventative lifestyle intervention assisted digital application including understanding factors may impact outcomes treatment uptake adherence work also inform development scaling personalization future interventions delay disability individuals risk adrd clinicaltrialsgov nct05027789 posted 8302021