Wei Ye
The impact of internet health information usage habits on older adults' e-health literacy
Digital health
childhood trauma amygdala play essential roles major depressive disorder mdd mechanisms however neurobiological mechanism among remains unclear therefore explored relationship among amygdala subregions abnormal functional connectivity fc clinical features childhood trauma mdd obtained restingstate functional magnetic resonance imaging fmri 115 mdd patients 91 wellmatched healthy controls hc amygdala subregions defined according human brainnetome atlas case vs control difference fcs extracted controlling age sex education years mediations detected abnormal fcs clinical features analyzed including onset age mdd hamilton depression scale24 hamd24 reductive rate compared hc subjects found right amygdala subregions namely right medial amygdala mamygr right lateral amygdala lamygr showed significant decrease wholebrain fcs mdd patients childhood abuse experiences significantly associated amygdala subregion connectivity clinical features mdd patients additionally fcs mamygr extensive frontal temporal subcortical regions mediated early life abuses disease onset treatment outcome findings indicate abnormal connectivity right amygdala subregions involved mdds pathogenesis clinical characteristics