Sarah M. Hartz|Emily Olfson|Robert Culverhouse|Patricia A. Cavazos?Rehg|Li?Shiun Chen|James M. DuBois|Sherri L. Fisher|Kimberly A. Kaphingst|David Kaufman|Andrew D. Plunk|Shelina Ramnarine|Stephanie Solomon|Nancy L. Saccone|Laura J. Bierut
Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change
Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Washington University in St. Louis|Johns Hopkins University|Washington University in St. Louis|Washington University in St. Louis|Saint Louis University|Washington University in St. Louis|Washington University in St. Louis
goal study examine participant responses disclosure genetic results minority population high risk depression anxietyeightytwo subjects genetic study nicotine dependence offered personalized genetic results nicotinedependent 64 selfidentified african american pathway genomics used evaluate genetic risks five complex diseases participants returned 48 weeks enrollment inperson genetic counseling interviews evaluation baseline measures telephone followup performed 48 weeks later assess responses resultsfifty 82 subjects 61 interested receiving genetic results participants multiple risk factors including high baseline measures depression 66 anxiety 32 well low rates employment 46 adequate health literacy 46 health insurance 45 pathway genomics reported increased risk least one disease 77 subjects ninetyfive percent participants reported appreciated genetic results receiving results associated changes symptoms depression anxiety furthermore return genetic results smoking cessation attempts increased p 0003even underserved population high risk adverse psychological reactions subjects responded positively personalized genetic results