Keisuke Inomura, Juan José Pierella Karlusich, Stephanie Dutkiewicz, Curtis Deutsch, Paul J Harrison, Chris Bowler
High Growth Rate of Diatoms Explained by Reduced Carbon Requirement and Low Energy Cost of Silica Deposition
Microbiology spectrum
increased left atrial volume decreased left atrial function long associated atrial fibrillation availability largescale cardiac magnetic resonance imaging data paired genetic data provides unique opportunity assess genetic contributions left atrial structure function understand relationship risk atrial fibrillation use deep learning surface reconstruction models measure left atrial minimum volume maximum volume stroke volume emptying fraction 40558 uk biobank participants genomewide association study 35049 participants without preexisting cardiovascular disease identify 20 common genetic loci associated left atrial structure function find polygenic contributions increased left atrial volume associated atrial fibrillation downstream consequences including stroke mendelian randomization find evidence supporting causal role left atrial enlargement dysfunction atrial fibrillation risk