Krysten Blackford, Malena Della Bona, Gemma Crawford
A preliminary analysis of passport to practice: investigating development of core competencies in undergraduate health promotion students
Global health promotion
hepatitis b virus hbv infection major risk factor hepatocellular carcinoma hcc programmed cell death pcd critical process suppressing tumor growth alterations pcdrelated genes may contribute progression hbvhcc study aims develop prognostic model incorporates genomic clinical information based pcdrelated genes providing novel insights molecular heterogeneity hbvhcc bioinformatics analysis experimental validation study analyzed 139 hbvhcc samples cancer genome atlas tcga validated 30 samples gene expression omnibus geo database various bioinformatics tools including differential expression analysis gene set variation analysis machine learning algorithms used comprehensive analysis rna sequencing data hbvhcc patients furthermore among pcdrelated genes ultimately chose dlat research tissue chips patient cohorts besides immunohistochemistry qrtpcr western blot analysis conducted cluster analysis identified three distinct subgroups hbvhcc patients among cluster 2 demonstrated significant activation dna replicationrelated pathways tumorrelated processes analysis copy number variations cnvs pcdrelated genes also revealed distinct patterns three subgroups may associated differences pathway activation survival outcomes dlat tumor tissues hbvhcc patients upregulated based pcdrelated genes developed prognostic model incorporates genomic clinical information provided novel insights molecular heterogeneity hbvhcc study emphasized significance pcdrelated genes particularly dlat examined vitro explore potential clinical implications