A A Akinlabi, A A Ojo, O A Akpor
Prevalence and Management Outcomes of Burns in a Teaching Hospital in Ekiti State, Nigeria: A Five-Year Review
Annals of burns and fire disasters
one severe monogenic conditions highest prevalence globe sickle cell disease although significance chronic anemia hemolysis vasculopathy established hemoglobin polymerization results erythrocyte stiffness vasoocclusion important pathophysiology disease clinical management elementary scant reliable data many treatments onset cerebrovascular illness cognitive impairment two major issues associated sickle cell disease children researchers beginning understand blood transfusions hydroxycarbamide prevent complications vaso occlusion inflammation occur repeatedly majority organs gradually damaged including brain kidneys lungs bones cardiovascular system damage worsens age study focused specific pathways affected involvement effected genes firstly retrieved gene datasets publically available data source website disgnet using literaturebased genes identified 290 highly regulated genes directly associated sickle cell disease subsequently performed gene expression analysis extracted gene set using geo2r analysis used prune 290 differentially expressed genes degs pruning got 60 highly expressed genes identification degs used genes pathway analysis pathway analysis used reactome software found degs directly associated 7 different pathways alpha beta signaling pathways 15 antiviral mechanism oligoadenylate synthetase oas antiviral response interleukin 1 signaling pathways interleukin 4 13 interleukin 10 signaling pathway aspirin adme pathway pathway analysis exactly relate sickle cell disease alters gene expression genes affect different pathways additionally performed gene ontology 60 genes identified gene biological process cellular component molecular functions mentioned results help study data chance preidentification sickle cell disease person gene result used biomarker sickle cell disease paper result primary approach sickle cell disease help paper researcher get primary data use research