Anna E. Bortnick|Kelly Epps|Faith Selzer|Saif Anwaruddin|Oscar C. Marroquin|Vankeepuram Srinivas|Elizabeth M. Holper|Robert L. Wilensky
Five-Year Follow-Up of Patients Treated for Coronary Artery Disease in the Face of an Increasing Burden of Co-Morbidity and Disease Complexity (from the NHLBI Dynamic Registry)
Albert Einstein College of Medicine|Montefiore Medical Center|Hospital of the University of Pennsylvania|University of Pittsburgh|Hospital of the University of Pennsylvania|University of Pittsburgh|UPMC Health System|Albert Einstein College of Medicine|Montefiore Medical Center|Medical City Dallas Hospital|Hospital of the University of Pennsylvania
management coronary artery disease cad evolved past decade prospective studies evaluating longterm outcomes realworld setting evolving technical approaches secondary prevention aim study determine mortality morbidity cad changed patients undergone percutaneous coronary intervention pci setting comorbidities evolving management national heart lung blood institute dynamic registry cohort study patients undergoing pci various time points cohorts enrolled 1999 cohort 2 n 2105 2004 cohort 4 n 2112 2006 cohort 5 n 2176 followed 5 years primary outcomes death myocardial infarction mi coronary artery bypass grafting repeat pci repeat revascularization secondary outcomes pci new obstructive lesions 5 years 5year rates death mi stratified severity coronary artery comorbid disease time patients likely multiple comorbidities severe cad despite greater disease severity significant difference death 165 vs 176 adjusted hazard ratio hr 089 95 confidence interval ci 074 108 mi 110 vs 106 adjusted hr 087 95 ci 070 108 repeat pci 204 vs 222 adjusted hr 098 95 ci 085 117 5year followup significant decrease coronary artery bypass grafting 91 vs 43 adjusted hr 044 95 ci 032 059 patients 5 comorbidities 40 60 death rate 5 years modestly high rate repeat pci new lesions indicating potential failure secondary prevention population face increasing comorbidity overall 5year rates death mi repeat pci repeat pci new lesions change significantly context increased comorbidities complex disease