Takele Gezahegn Demie, Getachew Tilahun Gessese
Household food insecurity and hunger status in Debre Berhan town, Central Ethiopia: Community-based cross-sectional study
Frontiers in nutrition
miniature postsynaptic current mpsc small rare highly variable spontaneous synaptic event generally caused spontaneous release single vesicles amplitude variability mpscs key measures postsynaptic processes taken main characteristics elementary unit quantal size traditional quantal analysis synaptic transmission due different sources biological measurement noise recordings mpscs exhibit high trialtotrial heterogeneity experimental measurements mpscs usually noisy scarce making analysis demanding present sequential procedure precise analysis mpsc amplitude distributions range small currents illustrate developed approach chose previously obtained experimental data effect extracellular matrix synaptic plasticity proposed statistical technique allowed us identify previously unnoticed additional modality mpsc amplitude distributions indicating formation new immature synapses upon ecm attenuation show approach reliably detect multimodality distributions mpsc amplitude allowing accurate determination size variability quantal synaptic response thus proposed method significantly expand informativeness existing newly obtained experimental data also demonstrated mpsc amplitudes around threshold microcurrent excitation follow gumbel distribution rather binomial statistics traditionally used wide range currents either single synapse taking consideration small influences adjacent synapses behaviour argued originate theory extreme processes specifically recorded mpscs represent instant random current fluctuations among relatively larger spikes extreme events required level coherence provided different mechanisms network system level activation including neuron circuit signalling extrasynaptic processes