Kellseigh Gan, Carly Tithecott, Lisa Neilson, Jamie A Seabrook, Paula Dworatzek
Picky Eating Is Associated with Lower Nutrient Intakes from Children's Home-Packed School Lunches
Nutrients
use composite outcome measures com clinical trials increasing whilst use associated benefits several limitations highlighted limited literature exploring use within critical care primary aim study evaluate use com highimpact critical care trials compare study parameters including sample size statistical significance consistency effect estimates trials using composite versus noncomposite outcomes systematic review 16 highimpact journals conducted randomised controlled trials published 2012 2022 reporting patient important outcome involving critical care patients included 8271 trials screened 194 included 391 trials used com increased time using com 526 explicitly described outcome composite median number components 2 iqr 23 trials using com recruited fewer participants 409 19888515 vs 584 3001566 p 0004 use associated increased rates statistical significance 197 vs 178 p 0380 predicted effect sizes overestimated 6 trials studies using com effect estimates consistent across components 434 trials 93 com included components patient important com increasingly used critical care trials however effect estimates frequently inconsistent across com components confounding outcome interpretations use com associated smaller sample sizes increased likelihood statistically significant results many limitations inherent use com relevant critical care research