Deirdre O’Shea|Robert Fieo|Jamie Hamilton|Laura B. Zahodne|Jennifer J. Manly|Yaakov Stern
Examining the association between late?life depressive symptoms, cognitive function, and brain volumes in the context of cognitive reserve
Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University
objective present study aimed investigate whether cognitive reserve moderated association depressive symptoms cognition well brain volumes sample older adults methods nondemented participants n 3484 selected washington heightshamilton heights inwood columbia aging project northern manhattan subsample participants without dementia n 703 brain imaging data also selected separate analysis depressive symptomatology assessed 10item center epidemiologic studies depression scale reading level years education used measures cognitive reserve four distinct cognitive composite scores calculated executive function memory visualspatial language results multiple regression analysis revealed interaction effects measures cognitive reserve depressive symptoms cognitive outcome measures except visualspatial ability greater reserve showed greater cognitive decrements lower levels reserve depressive symptoms increased borderline interaction effect revealed reading level depressive symptoms total brain volumes lower reading scores showed greater volume loss depressive symptoms increased higher reading scores conclusions findings indicate association latelife depressive symptoms core aspects cognition varies depending ones level cognitive reserve greater levels education andor reading ability showed greater decrease memory executive language performances depressive symptoms increased lower years education reading ability copyright 2014 john wiley amp sons ltd