Susanne Clinch, Stacie Hudgens, Elizabeth Gibbons, Tom Willgoss, Janice Smith, Ela Polek, Claire Burbridge
Quantitative and Qualitative Exploration of Meaningful Change on the Vineland Adaptive Behavior Scales (Vineland™-II) in Children and Adolescents with Autism Without Intellectual Disability Following Participation in a Clinical Trial
Patient related outcome measures
assess chatgpt 40 chatgpt gemini ultra 10 gemini large language models nonmem coding tasks relevant pharmacometrics clinical pharmacology chatgpt gemini assessed tasks mimicking realworld applications nonmem tasks ranged providing curriculum learning nonmem overview nonmem code structure generating code prompts lay language elicit nonmem code linear pharmacokinetic pk model oral administration complex model two parallel firstorder absorption mechanisms investigated reproducibility impact temperature hyperparameter settings assessed code reviewed two nonmem experts chatgpt gemini provided nonmem curriculum structures combining foundational knowledge advanced concepts eg covariate modeling bayesian approaches practical skills including nonmem code structure syntax chatgpt provided informative summary nonmem control stream structure outlined key nonmem translator nmtran records needed chatgpt gemini able generate code blocks nonmem control stream lay language prompts two coding tasks control streams contained focal structural syntax errors required revision could executed without errors warnings code output chatgpt gemini reproducible varying temperature hyperparameter reduce errors omissions substantively large language models may useful pharmacometrics efficiently generating initial coding template modeling projects however output contain errors omissions require correction