Mengdan Li, Ping Ni, Tingting Zuo, Yunyong Liu, Bo Zhu
Cancer literacy differences of basic knowledge, prevention, early detection, treatment and recovery: a cross-sectional study of urban and rural residents in Northeast China
Frontiers in public health
stillbirth 20 weeks gestation happens 1 200 pregnancies occurs commonly neonatal loss sudden infant death syndrome sids combined stillbirth rate several times greater low opposed highresource countries however among highresource countries although lower overall stillbirth rate exists little change several decades molecular genetic technologies emerging important contributors understanding stillbirth initially genetic etiologies included alterations chromosome number structure aneuploidy microduplications deletions recently nextgeneration sequencing analysis two genetic conditions smith lemli optiz syndrome slos channelopathy disorders long qt syndrome lqts provide examples association pathogenic gene variants stillbirth although specific conditions individually account small number stillbirths investigating disorders provides new innovative approach understanding genetic contributors adverse pregnancy outcomes knowledge role genetic disease etiology stillbirth elementary genomic interrogation maternalfetal genotypes genegene genotypeenvironment interaction lacking stillbirth research dna sequence level investigation variants unknown significance opportunity exploration biologic pathways importance pregnancy loss review concentrates slo example single gene disorder high carrier low affected liveborn proband rate channelopathy disorders included initial examples genetic conditions variable presentation including association sudden infant death syndrome highlighted challenges numerous genes variants involved task assigning pathogenicity advantages limitations genetic evaluations presented avenues research considered