T Holland, H Holland
A mathematical model of immunohistochemical preparations, which provides quantitative predictions
Journal of microscopy
latestage distribution bulky intraperitioneal disease hallmarks ovarian cancer presentation managed primarily surgical resection chemotherapy however advances surgical resection objectives alternative chemotherapy administration schedules novel therapeutics based increasing knowledge disease biology making strides improve outcomes review covers elements definition treatment biology ovarian cancer natural history ovarian cancer continues characterized latestage presentation metastatic bulky disease burden stagnant mortality statistics despite prolific drug development robust clinical investigation particularly modifications primary treatment surgical goals adjuvant therapy increasing median progressionfree survival overall survival although cure rates affected modestly maintenance therapy holds promise studies yet identify agent andor strategy affect survival recurrent disease largely incurable state however current intervention selected surgery combination targeted therapy investigational protocols impacting progressionfree survival ovarian cancer diverse genomically complex disease commands global attention rational investigation must balance high rate discovery lagging clinical investigation limited patient resources nevertheless growth armamentarium offers unprecedented opportunities patients suffering disease review presents reviews contemporary management disease spectrum termed epithelial ovarian cancer describes direction early results clinical investigation