Tom Broomhead, Rachael England, Stephen Mason, Michael Sereny, Sean Taylor, Georgios Tsakos, David Williams, Sarah R Baker
Using Standardised International Oral Health-Related Datasets in 6 Countries
International dental journal
block copolymers composed poly2oxazolines poly2oxazines serve drug delivery systems form micelles carry poorly watersoluble drugs many recent studies investigated effects structural changes polymer hydrophobic cargo drug loading work combine data establish extended formulation database different molecular properties fingerprints tested applicability serve formulationspecific mixture descriptors variety classification regression models built different descriptor subsets thresholds loading efficiency loading capacity best models achieving overall good statistics cross external validation balanced accuracies 08 subsequently important features dissected interpretation drugbank screened potential therapeutic use cases polymers could used develop novel formulations hydrophobic drugs promising models provided opensource software tool researchers test applicability delivery systems potential new drug candidates