David W Price, Peter Wingrove, Andrew Bazemore
Machine Learning to Identify Clusters in Family Medicine Diplomate Motivations and Their Relationship to Continuing Certification Exam Outcomes: Findings and Potential Future Implications
Journal of the American Board of Family Medicine : JABFM
data relationships environmental exposures asthma morbidity systemic il6 inflammation exist sought determine whether baseline plasma il6 level associated increased asthma morbidity children exposed mouse allergen innercity classrooms data longitudinal school innercity asthma studies 215 children asthma aged 4 14 years recruited urban elementary schools analyzed given unknown threshold il6 risk levels skewness distribution children stratified tertiles follows low baseline il6 level 0013 pgml moderate baseline il6 level 00130302 pgml high baseline il6 level 0302 pgml relationships plasma il6 level body mass index bmi percentile inflammatory markers lung function mouse allergen exposure asthma outcomes assessed crosssectional analysis demonstrated increasing il6 level associated higher bmi percentile p 0001 creactive protein level p 0006 blood neutrophil count p 0024 il6 associated type 2 inflammatory markers including blood eosinophil count allergic sensitization fractional exhaled nitric oxide level longitudinal analysis showed children high il6 levels higher number days asthma symptoms children moderate incidence rate ratio 174 95 ci 110277 p 0187 low incidence rate ratio 183 95 ci 121277 p 0043 il6 levels children high il6 levels exposed increasing levels mouse allergen exhibited lower ratios fev1 value forced vital capacity children moderate il6 levels 00044 95 ci 00073 00015 pairwise interaction p 0028 low il6 levels 00042 95 ci 00070 00013 pairwise interaction p 0039 innercity children asthma high plasma il6 levels likely increased bmi elevated creactive protein level elevated blood neutrophil count greater asthma symptoms high il6 level appears increase susceptibility effects classroom exposure mouse allergen lung function urban children