David R Mann, Christopher S Thomas, Raphael H Parrado, G Tyler Rives, Cynthia L Talley
Future Surgical Leaders: Resident Perception Of Longitudinal Leadership And Non-Technical Skills Curriculum
Journal of surgical education
neoadjuvant chemotherapy variable efficacy patients nonsmallcell lung cancer nsclc yet reliable noninvasive predictive markers lacking study aimed develop radiomics model predicting pathological complete response postneoadjuvant chemotherapy survival nsclc retrospective data collection involved 130 patients nsclc underwent neoadjuvant chemotherapy surgery patients randomly divided training independent testing sets nine radiomics features prechemotherapy computed tomography ct images extracted intratumoral peritumoral regions autoencoder model constructed performance evaluated xtile software classified patients high lowrisk groups based predicted probabilities survival patients different risk groups role postoperative adjuvant chemotherapy examined model demonstrated area receiver operating characteristic roc curve 0874 training set 0876 testing set larger area curve auc better model performance calibration curve decision curve analysis indicated excellent model calibration hosmerlemeshow test p 763 higher pvalue better model fit potential clinical applicability survival analysis revealed significant differences overall survival p 011 diseasefree survival p 017 different risk groups adjuvant chemotherapy significantly improved survival lowrisk group p 041 highrisk group p 056 study represents first successful prediction pathological complete response achievement neoadjuvant chemotherapy nsclc well patients survival utilizing intratumoral peritumoral radiomics features