Kaarin J. Anstey|Alex Bahar?Fuchs|Pushpani Herath|George W. Rebok|Nicolas Cherbuin
A 12-week multidomain intervention versus active control to reduce risk of Alzheimer’s disease: study protocol for a randomized controlled trial
Australian National University|Australian National University|Australian National University|Johns Hopkins University|Australian National University
disappointing results clinical trials diseasemodifying interventions alzheimers dementia ad along reliable identification modifiable risk factors mid life epidemiological studies contributed calls invest riskreduction interventions also well known adrelated pathological processes begin decade development clinical signs observations suggest lifestyle interventions might effective targeting nonsymptomatic adults risk ad date however dementia riskreduction programs available targeted individual risk factors andor restricted clinical settings current study describes development evidencebased theoreticallydriven multidomain intervention reduce ad risk adults riskthe design body brain life bbl randomized controlled trial rct evaluate 12week online ad riskreduction intervention eligible participants several modifiable risk factors australian national university anu ad risk index anuadri randomly allocated online group online facetoface group active control group aim recruit 180 participants undergo comprehensive cognitive physical assessment baseline postintervention 6month followup assessment intervention comprises seven online modules dementia literacy risk factor education engagement physical social cognitive lifestyles nutrition health monitoring designed using contemporary models health behavior changethe bbl program novel online intervention reduce risk ad middleaged adults risk trial currently way hypothesized participants intervention arms make lifestyle changes several domains lead reduction ad risk profile also expect show health behavior change underpinned changes psychological determinants behavior successful findings contribute development dementia risk reduction interventions thus contribute urgent need lower dementia risk factors population alter future projections disease prevalence longer followup bbl participants replications using large samples required examine whether reduction ad risk factors associated reduced prevalencereg actrn12612000147886