Ira Driscoll|J. C. Troncoso
Asymptomatic Alzheimers Disease: A Prodrome or a State of Resilience?
National Institute on Aging
neuritic plaques neurofibrillary tangles neuropathological hallmarks ad limited individuals dementia pathologic changes also present brains cognitively normal older adults condition defined asymptomatic ad asymad although remains unclear whether individuals would remain clinically normal longer survival seem able compensate delay appearance dementia symptoms provide historical background highlight combined clinical pathologic morphometric evidence related asymad understanding nature changes apparently asymptomatic state may shed light mechanisms forestall progression disease allow maintenance cognitive health important area research understudied relative identification risks pathways negative health outcomes