William Checkley|Keith P. West|Robert A. Wise|Matthew R. Baldwin|Lee Wu|Steven C. LeClerq|Parul Christian|Joanne Katz|James M. Tielsch|Subarna K. Khatry|Alfred Sommer
Maternal Vitamin A Supplementation and Lung Function in Offspring
Johns Hopkins University|Nepal Red Cross Society|Nepal Red Cross Society|Johns Hopkins University
vitamin important regulating early lung development alveolar formation maternal vitamin status may important determinant embryonic alveolar formation vitamin deficiency mother pregnancy could lasting adverse effects lung health offspring tested hypothesis examining longterm effects supplementation vitamin beta carotene women pregnancy lung function offspring population chronic vitamin deficiencywe examined cohort rural nepali children 9 13 years age whose mothers participated placebocontrolled doubleblind clusterrandomized trial vitamin betacarotene supplementation 1994 1997of 1894 children alive end original trial 1658 88 eligible participate followup trial performed spirometry 1371 children 83 eligible october 2006 march 2008 children whose mothers received vitamin forced expiratory volume 1 second fev1 forced vital capacity fvc significantly higher children whose mothers received placebo fev1 46 ml higher vitamin 95 confidence interval ci 6 86 fvc 46 ml higher vitamin 95 ci 8 84 adjustment height age sex bodymass index calendar month caste individual spirometer used children whose mothers received beta carotene adjusted fev1 fvc values similar children whose mothers received placebo fev1 14 ml higher beta carotene 95 ci 24 54 fvc 17 ml higher beta carotene 95 ci 21 55in chronically undernourished population maternal repletion vitamin recommended dietary levels pregnancy improved lung function offspring public health benefit apparent preadolescent years