Elizabeth Corsentino|Kathryn Sawyer|Natalie Sachs?Ericsson|Dan G. Blazer
Depressive Symptoms Moderate the Influence of the ApolipoproteinE ?4 Allele on Cognitive Decline in a Sample of Community Dwelling Older Adults
Florida State University|Florida State University|Florida State University|Duke University|Duke University Hospital|Duke Medical Center
apolipoproteine epsilon4 apoe epsilon4 allele history depression separate risk factors cognitive decline cd however little research investigated whether history depression influences relationship apoe epsilon4 cd present study examined whether depressive symptoms greater influence subsequent cd among participants apoe epsilon4 without alleleprospective 6year longitudinal studycommunity inhome interviewsa biracial sample community dwelling older adults n 1992 duke established populations epidemiologic studies elderly epesedata drawn waves 1 3 epese conducted 6 years apart cognitive functioning depressive symptoms assessed waves apoe genotyping completed wave 3 assessmentregression analyses revealed depressive symptoms apoe epsilon4 allele independently predicted cd importantly influence depressive symptoms cd greater individuals apoe epsilon4 allele compared without alleledepressive symptoms apoe epsilon4 allele independent contributors cd moreover influence depressive symptoms cd greater among individuals apoe epsilon4 allele depression apoe epsilon4 allele may act together disrupting neurological functioning may turn lower individuals cognitive reserve capacity given efficacious treatments currently available depression future research investigate extent interventions depression may reduce risk subsequent cd