Amy Lewin, Izidora Skracic, Ellie Brown, Kevin Roy
"The thing in my arm": Providing contraceptive services for adolescents in primary care
Women's health (London, England)
backoftheenvelope ruleofthumb calculations involving rough estimates quantities play central scientific role developing intuition structure behavior physical systems example socalled fermi problems physical sciences calculations used powerfully quantitatively reason biological systems particularly interface physics biology however substantial uncertainties often associated values cell biology performing calculations without taking uncertainty account may limit extent results interpreted given problem present means facilitate calculations uncertainties explicitly tracked line reasoning introduce probabilistic calculator called caladis free web tool designed perform tracking approach allows users perform statistically robust calculations cell biology despite uncertain values identify quantities need measured precisely make confident statements facilitating efficient experimental design illustrate use tool tracking uncertainty several example biological calculations showing results yield powerful interpretable statistics quantities interest also demonstrate outcomes calculations may differ point estimates uncertainty accurately tracked integral link caladis bionumbers repository biological quantities facilitates straightforward location selection use wealth experimental data cell biological calculations