Matthew J. O’Brien|Robert C. Whitaker|Daohai Yu|Ronald T. Ackermann
The comparative efficacy of lifestyle intervention and metformin by educational attainment in the Diabetes Prevention Program
Northwestern University|Temple University|Temple University|Northwestern University
educational attainment inversely associated type 2 diabetes risk unknown whether education impacts individuals diabetes prevention efforts examined comparative efficacy intensive lifestyle intervention metformin educational attainment among participants diabetes prevention program dpp ongoing us multisite trial beginning 1996we studied 2910 dpp participants randomized receive lifestyle intervention metformin placebo stratifying educational attainment diabetes incidence relative risk reductions treatment assignment estimated using cox proportional hazards regression47 participants completed college 53 compared placebo lifestyle participants completed college demonstrated 68 reduction diabetes incidence 95 ci56 77 whereas less education experienced 47 risk reduction 95 ci29 61 metformin participants college graduates experienced 49 relative risk reduction 95 ci33 62 compared 23 95 ci1 41 among lower educational attainment statistically significant educationbytreatment interaction incident diabetes p003intensive lifestyle intervention metformin greater efficacy among highly educated individuals future efforts deliver treatments study dissemination may effective tailored individuals educational background