Alessandra Cardozo Machado Suga, Alexandre Augusto de Paula da Silva, Josieli Regina Brey, Paulo Henrique Guerra, Ciro Romelio Rodriguez-Añez
Effects of interventions for promoting physical activity during recess in elementary schools: a systematic review
Jornal de pediatria
warburg effect longstanding enigma cancer biology despite passage 100 yr since discovery accumulation vast body research subject convincing biochemical explanation given original observations aerobic glycolysis cancer cell metabolism worked firstprinciples quantitative analysis problem principles stoichiometry available electron balance results interpreted using naths unified theory energy coupling adenosine triphosphate atp synthesis original data warburg colleagues analyzed new perspective use biomass yield based atp per unit substrate consumed formula see text nathwarburg number nawa shown excellently model original data warburg effect small standard deviation values without employing additional fitted adjustable parameters based results quantitative analysis novel conservative mechanism synthesis utilization recycling atp key metabolites eg lactate proposed mechanism offers fresh insights metabolic symbiosis coupling within andor among proliferating cells fundamental understanding gained using approach help catalyzing development efficient metabolismtargeting anticancer drugs