José Marcelo Farfel|Ricardo Nitríni|Cláudia Kimie Suemoto|Lea T. Grinberg|Renata E.L. Ferretti|Renata Elaine Paraízo Leite|Edilaine Tampellini|Luzia Carreira Lima|Daniela Souza Farias|Ricardo Caires Neves|Roberta Diehl Rodriguez|Paulo Rossi Menezes|Felipe Fregni|David A. Bennett|Carlos Augusto Pasqualucci|Wilson Jacob Filho
Very low levels of education and cognitive reserve
Universidade de São Paulo
h3objectiveh3 conducted clinicopathologic study large population low levels education determine whether years education could contribute cognitive reserve modify relation neuropathologic indices dementia h3methodsh3 crosssectional study included 675 individuals 50 years age older brazilian aging brain study group cognitive abilities evaluated structured interview informant time autopsy including clinical dementia rating cdr scale neuropathologic examinations performed using immunohistochemistry following internationally accepted criteria multivariate linear regression models conducted determine whether association cognitive abilities measured cdr sum boxes years education independent sociodemographic variables neuropathologic indices including neuritic plaques neurofibrillary tangles lacunar infarctions smallvessel disease lewy bodies addition interaction models used examine whether education modified relation neuropathologic indices cognition h3resultsh3 mean education 39 35 years formal education associated lower cdr sum boxes 0197 95 confidence interval 0343 0052 ipi 0008 adjustment sociodemographic variables neuropathologic indices furthermore education modified relationship lacunar infarcts cognitive abilities ipi 004 h3conclusionsh3 even years formal education contributes cognitive reserve