Erin M. Jonaitis|Rebecca L. Koscik|Lindsay R. Clark|Yue Ma|Tobey J Betthauser|Sara E. Berman|Samantha L. Allison|Kimberly D. Mueller|Bruce P. Hermann|Carol A. Van Hulle|Bradley T. Christian|Barbara B. Bendlin|Kaj Blennow|Henrik Zetterberg|Cynthia M. Carlsson|Sanjay Asthana|Sterling C. Johnson
Measuring longitudinal cognition: Individual tests versus composites
University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Wisconsin–Madison|University of Gothenburg|Sahlgrenska University Hospital|University of Gothenburg|Sahlgrenska University Hospital|National Hospital for Neurology and Neurosurgery|University College London|UK Dementia Research Institute|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center|University of Wisconsin–Madison|University of Wisconsin–Madison|William S. Middleton Memorial Veterans Hospital|Geriatric Research Education and Clinical Center
longitudinal cohort studies cognitive aging must confront several sources withinperson variability scores article compare several neuropsychological measures terms longitudinal error variance relationships biomarkerassessed brain amyloidosis aanalyses used data wisconsin registry alzheimers prevention quantified withinperson longitudinal variability agerelated trajectories several global domainspecific composites constituent scores subset cerebrospinal fluid amyloid positron emission tomography measures examined modified cognitive trajectoriesglobal theoretically derived composites exhibited lower intraindividual variability stronger age interactions empirically derived composites raw scores single tests example theoretical executive function outperformed executive function scores metricsthese results reinforce need careful selection cognitive outcomes study design support emerging consensus favoring composites singletest measures