Humphrey G M Walker, Alastair J Brown, Ines P Vaz, Rebecca Reed, Max A Schofield, Jeffrey Shao, Vinodh B Nanjayya, Andrew A Udy, Toby Jeffcote
Composite outcome measures in high-impact critical care randomised controlled trials: a systematic review
Critical care (London, England)
cryptosporidiosis recognized significant cause gastrointestinal illness due wide range vertebrate hosts including humans infection cryptosporidium spp especially common young domestic ruminants calves lambs goat kids associated economic losses worldwide contrast cattle date detailed studies cryptosporidium infections sheep europe still limited thus importance reservoirs cryptosporidium species implications animal public health still needs clarified study evaluates prevalence zoonotic potential cryptosporidium spp sheep farms italy total 915 individual faecal samples divided three different animal categories collected 61 sheep farms sample examined microscopy faecal smears stained modified ziehlneelsen biomolecular techniques cryptosporidium oocysts detected 101 animals examined 344 farms prevalence cryptosporidium spp significantly higher 2 51854 p 0001 diarrhoeic samples pasty normal faeces genotype analyses showed presence two cryptosporidium species c parvum c ubiquitum subtyping analysis c parvum isolates revealed presence subtypes iia15g2r1 iida20g1 subtype xiia c ubiquitum findings public health implications since cryptosporidium species identified considered zoonotic c parvum secondmost common cryptosporidium species infecting humans data reveal lambs especially excreting diarrhoeic faeces may important reservoirs cryptosporidium also highlight need establish adequate control monitoring programmes control infection sheep farms primarily coprological monitoring