Martin Prince|Daisy Acosta|Cleusa P. Ferri|Mariella Guerra|Yueqin Huang|Juan J. Llibre Rodriguez|Aquiles Salas|Ana Luisa Sosa|Joseph Williams|Michael Dewey|Isaac Acosta|Amuthavalli T Jotheeswaran|Zhaorui Liu
Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study
King's College London|Universidad Nacional Pedro Henríquez Ureña|King's College London|Instituto de la Memoria Depresión y Enfermedades de Riesgo|Peking University|Peking University Sixth Hospital|University of Havana|Central University of Venezuela|Hospital Clínico Universitario de Caracas|Instituto Nacional de Neurología y Neurocirugía|Voluntary Health Services Hospital|King's College London|Instituto Nacional de Neurología y Neurocirugía|Public Health Foundation of India|Peking University|Peking University Sixth Hospital
results cohort studies countries low incomes middle incomes suggest lower incidence dementia highincome countries assessed incidence dementia according criteria 1066 dementia research group diagnostic statistical manual mental disorders dsm iv effect dementia baseline mortality independent effects age sex socioeconomic position indicators cognitive reservewe populationbased cohort study people aged 65 years older living urban sites cuba dominican republic venezuela rural urban sites peru mexico china ascertainment incident 1066 dsmiv dementia 35 years cohort inception used questionnaires obtain information age years sex educational level literacy occupational attainment number household assets obtained information mortality sites participants died interviewed friend relative ascertain likelihood dementia death12887 participants interviewed baseline 11718 free dementia 8137 69 reinterviewed contributing 34718 personyears followup incidence 1066 dementia varied 182 304 per 1000 personyears 1427 times higher dsmiv dementia 99157 per 1000 personyears mortality hazards 156569 times higher individuals dementia baseline dementiafree informant reports suggested high incidence dementia death overall incidence might 419 higher data included 1066 dementia incidence independently associated increased age hr 167 95 ci 156179 female sex 072 061084 low education 089 081097 occupational attainment 104 095113our results provide supportive evidence cognitive reserve hypothesis showing middleincome countries highincome countries education literacy verbal fluency motor sequencing confer substantial protection onset dementiawellcome trust health consequences population change programme us alzheimers association fonacit cdch ucv