July D Nelson, Mendy E Dunn, Yulia A Levites Strekalova
Pilot implementation of a co-mentoring circles program for the clinical research professionals: Evidence for formative evaluation and logic model
Journal of clinical and translational science
human h3n2 influenza viruses subject rapid antigenic evolution translates frequent updates composition seasonal influenza vaccines despite updates effectiveness influenza vaccines h3n2associated disease suboptimal seasonal influenza vaccines primarily induce hemagglutininspecific antibody responses however antibodies directed influenza neuraminidase na also contribute protection analysed antigenic diversity panel n2 nas derived human h3n2 viruses circulated 2009 2017 antigenic breadth nas determined based na inhibition nai broad panel ferret mouse immune sera raised infection recombinant n2 na immunisation assessment allowed us distinguish least four antigenic groups n2 nas derived human h3n2 viruses circulated 2009 2017 computational analysis revealed amino acid residues n2 na major impact susceptibility nai immune sera proximity catalytic site finally machine learning method developed allowed accurately predict impact mutations present n2 na panel nai findings important implications renewed interest develop improved influenza vaccines based inclusion protective na antigen formulation