O Parker Martinez, Katharine Storo, Zachary Provenzano, Eric Murphy, Tadaki M Tomita, Samantha Cox
A systematic review and meta-analysis on the influence of sociodemographic factors on amputation in patients with peripheral arterial disease
Journal of vascular surgery
objective triplenegative breast cancer tnbc represents aggressive prognostically poor variant breast cancer years detailed research conducted published western literature however lacks detailed account tnbc cases perspective lowvolume institution study aims assess clinical features tnbc well prognostic implications tertiary care centre methods materials prospective observational study took place tertiary health centre two years spanning 2021 2023 study aimed investigate various clinicopathological epidemiological parameters thereby highlighting shortcomings existing knowledge subject context lowvolume centre well additional contributing factors developing countries like india group 150 participants diagnosed tnbc biopsy immunohistochemistry 40 years age included study patients tested positive hormonal receptors refused give consent participation excluded study study subjects categorized according clinical tnm ctnm stage eventually segregated two primary heads namely presurgery chemotherapy breastconserving surgery bcs good response modified radical mastectomy mrm upfront important demographic details including age socioeconomic status education also recorded comprehensive followup assessment posttreatment performed detect early recurrence data collection recurrence rates correlated tnbc status establish aggressiveness cancer statistical analysis data done using statistical package social sciences spss 16version software results average age 150 participants study 5221 years sd489 years highest recorded age 64 years lowest recorded age 45 years study observed 41 participants diagnosed tnbc stage iii disease whereas 335 stage disease 22 stage iv disease 36 stage ii disease total 275 individuals tnbc exhibited metastases various anatomical sites whereas 725 show signs metastasis conclusion triplenegative breast cancer earned position unique subtype breast cancer due unusual molecular characteristics aggressive behavior limited treatment options poor prognosis lower percapita income limited knowledge pertaining variant along absence specific treatment options contribute already high levels morbidity mortality associated illness effectively address unique virulent ailment customize strategies imperative comprehensive investigations thereby enabling us deliver highest quality medical attention individuals afflicted pathology