John M. Brehm|Juan C. Celed?n|Manuel Soto-Quirós|Lydiana Avila|Gary M. Hunninghake|Erick Forno|Daniel Laskey|Jody S. Sylvia|Bruce W. Hollis|Scott T. Weiss|Augusto A. Litonjua
Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
Harvard University|Brigham and Women's Hospital|Hospital Nacional de Niños|Hospital Nacional de Niños|Harvard University|Harvard University|Boston Children's Hospital|Medical University of South Carolina|Harvard University|Brigham and Women's Hospital
rationale maternal vitamin intake pregnancy inversely associated asthma symptoms early childhoodhowever study examined relationship measured vitamin levels markers asthma severity childhoodobjectives determine relationship measured vitamin levels markers asthma severity allergy childhoodmethods examined relation 25hydroxyvitamin levels major circulating form vitamin markers allergy asthma severity crosssectional study 616 costa rican children ages 6 14 yearslinear logistic negative binomial regressions used univariate multivariate analysesmeasurements main results 616 children asthma 175 28 insufficient levels vitamin 30 ngmlin multivariate linear regression models vitamin levels significantly inversely associated total ige eosinophil countin multivariate logistic regression models log 10 unit increase vitamin levels associated reduced odds hospitalization previous year odds ratio 005 95 confidence interval ci 0004071p 5 003 use antiinflammatory medications previous year 018 95 ci 005067p 5 001 increased airway responsiveness 858mmol provocative dose methacholine producing 20 fall baseline fev 1 015 95 ci 0024097p 5 005conclusions results suggest vitamin insufficiency relatively frequent equatorial population children asthmain children lower vitamin levels associated increased markers allergy asthma severity