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generic medicines clinically equivalent used interchangeably intended use globally usage generic medicines highly recommended affordability accessibility however consumers hold negative perception attitude using generic medicine consider poor inferior quality compared branded medicines study conducted assess consumers general view generic medicines vitro evaluation locally produced generic medicine paracetamol analytical crosssectional study conducted three selected hospitals vitro quality control evaluation done national drug quality control laboratory october 26 november 21 2017 asmara eritrea systematic random sampling design employed data collected using questionnaire checklist recording quality control parameters paracetamol tablets total 403 respondents included study majority study participants females 618 generally half 491 respondents choose locally manufactured paracetamol imported ones half 685 respondents believe expensive medicines better quality main reason consumers prefer local paracetamol azemol tablet imported one due good experience 621 threefourths 781 consumers also believed medicines manufactured abroad confer higher quality multivariate level educational backgrounds elementary aor 419 95 ci 1251 14035 junior aor 24 95 ci 1146 5028 associated preferability local paracetamol pain killer brand ones vitro test local paracetamol met standard specification identification test weight variation test pharmacopeial test friability test disintegration test dissolution test conclusion majority consumers considered local paracetamol inferior quality compared brand paracetamol however reality revealed local paracetamol quality brand ones facilitate widespread use generic medicines healthcare professionals educate consumers advantages medicines