Christine Roth|Per Magnus|Synnve Schjølberg|Camilla Stoltenberg|Pål Surén|Ian W. McKeague|George Davey Smith|Ted Reichborn?Kjennerud|Ezra Susser
Folic Acid Supplements in Pregnancy and Severe Language Delay in Children
Norwegian Institute of Public Health
h3contexth3prenatal folic acid supplements reduce risk neural tube defects may beneficial effects aspects neurodevelopmenth3objectiveh3to examine associations mothers use prenatal folic acid supplements risk severe language delay children age 3 yearsh3design setting patientsh3the prospective observational norwegian mother child cohort study recruited pregnant women 1999 december 2008 data children born 2008 whose mothers returned 3year followup questionnaire june 16 2010 used maternal use folic acid supplements within interval 4 weeks 8 weeks conception exposure relative risks approximated estimating odds ratios ors 95 cis logistic regression analysish3main outcome measureh3childrens language competency age 3 years measured maternal report 6point ordinal language grammar scale children minimal expressive language 1word unintelligible utterances rated severe language delayh3resultsh3among 38 954 children 204 05 severe language delay children whose mothers took dietary supplements specified exposure interval reference group n 9052 240 severe language delay 81 children 09 adjusted ors 3 patterns exposure maternal dietary supplements 1 supplements folic acid n 2480 66 severe language delay 22 children 09 104 95 ci 062174 2 folic acid n 7127 189 severe language delay 28 children 04 055 95 ci 035086 3 folic acid combination supplements n 19 005 505 severe language delay 73 children 04 055 95 ci 039078h3conclusionh3among norwegian cohort mothers children maternal use folic acid supplements early pregnancy associated reduced risk severe language delay children age 3 years