Deborah L. Jones|Karl Peltzer|Stephen M. Weiss|Sibusiso Sifunda|Ntabozuko Dwane|Shandir Ramlagan|Ryan Cook|Gladys Matseke|V. Maduna|Andrew Spence
Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial
University of Miami|Human Sciences Research Council|University of Miami|Human Sciences Research Council|Human Sciences Research Council|Human Sciences Research Council|University of Miami|Human Sciences Research Council|Human Sciences Research Council|University of Miami
rural south africa twothirds hivpositive pregnant women seeking antenatal care community health centers took full advantage prevention mothertochild transmission pmtct services 2010 studies generally support male involvement promote pmtct nature impact involvement unclear untested additionally stigma disclosure intimate partner violence pose significant barriers pmtct uptake retention care suggesting male involvement may necessary sufficient reduce infant hiv incidence study expands successful united states presidents emergency plan aids relief pepfarsupported pmtct couples intervention pilot study conducted mpumalanga province targeting hivpositive pregnant women partners primary objective determine whether male partner involvement plus behavioral intervention significantly reduce infant hiv incidencethe study follows cluster randomized controlled design enrolling two cohorts hivpositive pregnant women recruited 12 randomly assigned community health centers chc six experimental six control two cohorts consist women attending without male partners n 720 women attending male partners n 720 couples order determine whether influence male participation combined behavioral pmtct intervention significantly reduce infant hiv infection ante peri postnatallyit intention significantly increase pmtct participation current levels 69 mpumalanga province 90 95 engaging women couples controlled six session ante postnatal riskreducing pmtct promotion intervention addressing barriers pmtct stigma disclosure intimate partner violence communication infant feeding practices safer conception prevent women men utilizing treatment opportunities available infants based upon encouraging preliminary results pilot study successful chc adoption program could major public health policy implications containing epidemic among vulnerable populations rural south africa hivpositive pregnant women infantsclinicaltrialsgov nct02085356 registration date 10 march 2014