Katherine L Rosettie, Renata Micha, Frederick Cudhea, Jose L Peñalvo, Martin O'Flaherty, Jonathan Pearson-Stuttard, Christina D Economos, Laurie P Whitsel, Dariush Mozaffarian
Comparative risk assessment of school food environment policies and childhood diets, childhood obesity, and future cardiometabolic mortality in the United States
PloS one
identify predictors moderators response acute treatments among depressed adolescents n 439 randomly assigned fluoxetine cognitivebehavioral therapy cbt fluoxetine cbt clinical management pill placebo treatment adolescents depression study tadspotential baseline predictors moderators identified literature review outcome measure week 12 predicted score derived childrens depression rating scalerevised cdrsr candidate moderator predictor general linear model conducted examine main interactive effects treatment candidate variable cdrsr predicted scoresadolescents younger less chronically depressed higher functioning less hopeless less suicidal ideation fewer melancholic features comorbid diagnoses greater expectations improvement likely benefit acutely counterparts combined treatment condition less effective monotherapy effective fluoxetine mild moderate depression depression high levels cognitive distortion severe depression depression low levels cognitive distortion adolescents highincome families likely benefit cbt alone combined treatmentyounger less severely impaired adolescents likely respond better acute treatment older impaired multiply comorbid adolescents family income level cognitive distortions severity depression may help clinicians choose among acute interventions combined treatment proved robust presence moderators