Belinda Judd, Jennie Brentnall, Justin Newton Scanlan, Kate Thomson, Felicity Blackstock, Allison Mandrusiak, Lucy Chipchase, Anna Phillips, Sue McAllister
Evaluating allied health students' readiness for placement learning
BMC medical education
study tested prefrontal hippocampal functions sample 28 schoolaged 147 years sd 27 individuals syndrome ds compared 28 49 years sd 75 typically developing children individually matched mental age neuropsychological domains tested multiple behavioral measures benchmark measures verbal spatial function demonstrated ds sample similar others literature main finding significant group x domain interaction effect indicating differential hippocampal dysfunction group ds however moderate partial correlation r 54 controlling chronological age hippocampal prefrontal composite scores ds group composites contributed unique variance prediction adaptive behavior group sum results indicate particular weakness hippocampal functions ds context overall cognitive dysfunction interesting results similar found mouse model ds model make easier understand neurobiological mechanisms lead development hippocampal dysfunction ds