Nadezhda Koriakina, Nataša Sladoje, Vladimir Bašić, Joakim Lindblad
Deep multiple instance learning versus conventional deep single instance learning for interpretable oral cancer detection
PloS one
fracture begets fracture pharmacological treatment needed prevent secondary fractures study found fragility fracture care gap bone health investigations treatment initiation rates low strategies fracture liaison service needed address care gap study aimed investigate clinical burden secondary fracture prevention fragility fractures tertiary teaching hospital malaysia electronic medical records patients admitted fragility fractures 1 january 201731 december 2018 reviewed patients 50 years old nonfragility fractures restricted access medical records transferred another hospital passed away admission excluded descriptive statistics used summarise patients characteristics frequency fragility fractures secondary fracture prevention details binomial logistic regression performed analyse predictive factors postfracture bone health assessments treatment initiation 1030 patients female 7671030 745 presented 1071 fractures hip fractures 3781071 353 170993 171 patients initiated antiosteoporosis medications aoms 148984 150 bone mineral density bmd performed within 1year postfracture less half 424 patients remained treatment 1year postfracture older patients 6574 years old odds ratio 218 95ci 105452 p 004 75 years 306 95ci 154607 p 001 hip fractures 195 95ci 123311 p 001 chinese ethnicity 190 95ci 107335 p 003previously diagnosed osteoporosis 265 95ci132531 p 001 bmd test performed 1248 95ci 8041937 p 001 found higher aom initiation patients past diagnosis osteoporosis 445 95ci 225881 p 001 initiated aom 1134 95ci 7571697 p 001 higher likelihood undergo bmd testing aom initiation bmd testing rates low need address fragility fracture care gap strategies fracture liaison service