David Gozal|Abdelnaby Khalyfa|Óscar Sans Capdevila|Leila Kheirandish?Gozal|Ahamed Khalyfa|Jinkwan Kim
Cognitive Function in Prepubertal Children with Obstructive Sleep Apnea: A Modifying Role for NADPH Oxidase p22 Subunit Gene Polymorphisms?
University of Chicago|University of Chicago|Hospital Sant Joan de Déu Barcelona|University of Chicago|University of Chicago|University of Chicago
pediatric obstructive sleep apnea osa may lead neurocognitive dysfunction everyone affected frequencies nadph oxidase nox polymorphisms p22phox subunit similar children osa controls except rs6520785 rs4673 latter significantly frequent among osa children without deficits deficits p002 similarly 8hydroxydeoxyguanine urine levels nox activity lower among children without cognitive deficits particularly among rs4673 polymorphism thus polymorphisms within nox gene functional subunits may account important components variance cognitive function deficits associated osa children antioxid redox signal 16 171177