Carl?Gustaf Bornehag|Christian Lindh|Abraham Reichenberg|Sverre Wikström|Maria Unenge Hallerbäck|Sarah Evans|Sheela Sathyanarayana|Emily S. Barrett|Ruby H.N. Nguyen|Nicole R. Bush|Shanna H. Swan
Association of Prenatal Phthalate Exposure With Language Development in Early Childhood
Karlstad University|Icahn School of Medicine at Mount Sinai|Lund University|Icahn School of Medicine at Mount Sinai|Örebro University|Karlstad University|Icahn School of Medicine at Mount Sinai|University of Washington|Rutgers, The State University of New Jersey|University of Minnesota System|University of California, San Francisco|Icahn School of Medicine at Mount Sinai
prenatal exposure phthalates associated neurodevelopmental outcomes little known association language developmentto examine association prenatal phthalate exposure language development children 2 populationbased pregnancy cohort studiesdata study obtained swedish environmental longitudinal mother child asthma allergy selma study conducted prenatal clinics throughout vrmland county sweden infant development environment study tides conducted 4 academic centers united states participants recruited studies women first trimester pregnancy literacy swedish selma english spanish tides study included mothers children selma study n 963 tides n 370 complete data prenatal urinary phthalate metabolite levels language delay modeled covariables selma data collected november 1 2007 june 30 2013 data analysis conducted november 1 2016 june 30 2018 tides data collection began january 1 2010 ended march 29 2016 data analysis performed september 15 2016 june 30 2018mothers completed language development questionnaire asked number words children could understand use median 30 months age selma 37 months age tides responses categorized fewer 25 25 50 50 words 50 words fewer classified language delayin selma study 963 mothers 455 472 girls 508 528 boys included tides 370 mothers 185 500 girls 185 500 boys included analysis prevalence language delay 100 selma 96 reported tides 37 reported higher rates delay boys girls selma 69 135 vs 27 60 tides 23 124 vs 14 76 crude analyses metabolite levels dibutyl phthalate butyl benzyl phthalate statistically significantly associated language delay cohorts adjusted analyses doubling prenatal exposure dibutyl phthalate butyl benzyl phthalate metabolites increased odds ratio language delay approximately 25 40 statistically significant results selma study dibutyl phthalate 129 95 ci 103163 p 03 butyl benzyl phthalate 126 95 ci 107149 p 003 doubling prenatal monoethyl phthalate exposure associated approximately 15 increase language delay selma study 114 95 ci 100131 p 05 association found tides 098 95 ci 079123in findings study prenatal exposure dibutyl phthalate butyl benzyl phthalate statistically significantly associated language delay children selma study tides findings along prevalence prenatal exposure phthalates importance language development inconsistent results 2017 danish study suggest association phthalates language delay may warrant examination