Anila M. D’Mello|Catherine J. Stoodley
Cerebro-cerebellar circuits in autism spectrum disorder
American University|American University
cerebellum one consistent sites abnormality autism spectrum disorder asd cerebellar damage associated increased risk asd symptoms suggesting cerebellar dysfunction may play crucial role etiology asd cerebellum forms multiple closedloop circuits cerebral cortical regions underpin movement language social processing circuits cerebellar dysfunction could impact core asd symptoms social communication deficits repetitive stereotyped behaviors emerging topography sensorimotor cognitive affective subregions cerebellum provides new framework interpreting significance regional cerebellar findings asd relationship broader cerebrocerebellar circuits recent research supports idea integrity cerebrocerebellar loops might important early cortical development disruptions specific cerebrocerebellar loops asd might impede specialization cortical regions involved motor control language social interaction leading impairments domains consistent concept structural functional differences sensorimotor regions cerebellum sensorimotor cerebrocerebellar circuits associated deficits motor control increased repetitive stereotyped behaviors asd communication social impairments associated atypical activation structure cerebrocerebellar loops underpinning language social cognition finally converging evidence structural functional connectivity neuroimaging studies cerebellar right crus iii abnormalities related severe asd impairments domains propose cerebellar abnormalities may disrupt optimization structure function specific cerebrocerebellar circuits asd