Sophia Giazitzidou, Susana Padeliadu
Contribution of morphological awareness to reading fluency of children with and without dyslexia: evidence from a transparent orthography
Annals of dyslexia
cardioswitchstudy demonstrated patients solid tumors develop cardiotoxicity capecitabine 5fluorouracil 5fu treatment safely switched s1 alternative fluoropyrimidine fp light european medicines agency approval s1 metastatic colorectal cancer mcrc analysis provides detailed safety efficacy information data regarding metastasectomy andor local ablative therapy lat mcrc patients original study retrospective cohort study conducted 12 european centers primary endpoint recurrence cardiotoxicity switch analysis safety data reported 78 mcrc patients cardioswitch cohort n 200 detailed efficacy outcomes data available 66 mcrc patients data safety s1 mcrc patients similar original cardioswitch cohort expected fpbased treatment new concerns recurrent cardiotoxicity grade 1 s1based treatment occurred 478 5 mcrc patients able complete fp treatment median progressionfree survival initiation s1based treatment 90 months median overall survival 267 months metastasectomy andor lat performed 3366 50 patients s1 successfully used recommended neoadjuvantconversion adjuvantlike combination regimens schedules standard fps s1 safe effective fp alternative mcrc patients forced discontinue 5fu capecitabine due cardiotoxicity safely used standard recommended regimens settings schedules