Christine A. Pace|Ambrose Talisuna|David Wendler|Faustin Maiso|Fred Wabwire?Mangen|Nathan Bakyaita|Edith Okiria|Elizabeth S. Garrett-Mayer|Ezekiel J. Emanuel|Christine Grady
Quality of Parental Consent in a Ugandan Malaria Study
Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health|Ministry of Health
surveyed ugandan parents enrolled children randomized pediatric malaria treatment trial evaluate parents levels understanding treatment trial quality parents consents allow children participate studywe conducted 347 interviews immediately following enrollment 4 ugandan sitesa majority 78 parents mothers 86 primary school education participating mothers substantial percentage reported remembered told studys purpose 77 required number visits 88 risks involved 61 treatment allocation 84 ability discontinue childrens participation 64 addition reported knowing trials purpose 80 required number visits 78 however 18 could name possible side effects drugs administered 19 knew children would administered identical treatments ninetyfour percent reported made enrollment decision 58 said felt pressure participate childs illness 15 said felt type pressure participate others 41 reported knowing participatethe consent ugandan parents provided allow children participate malaria study mixed quality parents understood many study details aware risks involved randomization many parents felt could refused participate child sick either know believe child would receive treatment outside study results indicate debate needed informed consent treatment studies emergent illnesses children