Mia Djulbegovic, Jason Beckstead, Shira Elqayam, Tea Reljic, Ambuj Kumar, Charles Paidas, Benjamin Djulbegovic
Thinking Styles and Regret in Physicians
PloS one
patients adultonset huntingtons disease aohd found dysfunction autonomic nervous system thought secondary neurodegeneration causing dysfunction brainheart axis however relationship investigated patients juvenileonset hd johd aim study compare simple physiologic measures patients johd n 27 participants 64 visits participants without gene expansion causes hd gne group n 259 participants 395 visits using data kidsjohd study compared mean resting heart rate rhr systolic blood pressure sbp diastolic blood pressure dbp johd gne groups also divided johd group childhoodonset johd motor diagnosis received age 13 n 16 adolescentonset johd motor diagnosis received age 13 n 11 used linear mixedeffects models compare group means controlling age sex parental socioeconomic status including random effect per participant family primary analysis found johd group significant increases rhr compared gne group conversely johd group significantly lower sbp compared gne group johd group also lower dbp compared gne group results reach significance sbp dbp decreased disease duration johd increased rhr continue increase resting heart rate sensitive changes autonomic function compared sbp therefore results seem indicate early neurodegenerative changes central autonomic network likely lead increase rhr later progression johd leads changes blood pressure hypothesize later changes blood pressure secondary neurodegeneration brainstem regions medulla