Janice E. Williams|Marc I. Chimowitz|George Cotsonis|Michael Lynn|Salina P. Waddy
Gender Differences in Outcomes Among Patients With Symptomatic Intracranial Arterial Stenosis
Emory University|Emory University|Emory University|Emory University|Emory University
limited conflicting data gender differences clinical outcomes among patients symptomatic intracranial arterial stenosis study examined gender differences patients enrolled warfarinaspirin symptomatic intracranial disease wasid studyparticipants 569 men women symptomatic intracranial arterial stenosis followedup occurrence ischemic stroke combined end point stroke vascular death february 1999 july 2003 mean followup 18 yearstwoyear rates primary end point 284 166 women men respectively cumulative probabilities outcomes time estimated kaplanmeier productlimit method compared men women use logrank test cox proportional hazards regression analyses used estimate hazard ratio gender women men ischemic stroke primary end point probabilities ischemic stroke p0005 combined end point stroke vascular death p0017 time significantly higher women men women greater multivariateadjusted risk ischemic stroke hr 185 95 ci 114 301 p0013 combined end point stroke vascular death hr 158 95 ci 101 248 p0045women symptomatic intracranial arterial stenosis significantly greater risk ischemic stroke combined end point stroke vascular death findings suggest need vigorous screening risk factors aggressive management risk factors stroke women also suggest need ensure adequate numbers women clinical trials designed explore new promising therapies intracranial arterial stenosis