C D Morris, J D Bransford
Effective elaboration and inferential reasoning
Memory & cognition
persistent functional impairment common bipolar disorder bd influenced number demographic clinical cognitive features goal project estimate compare influence key factors community function multiple cohorts wellcharacterized samples individuals bd thirteen cohorts 7 countries included n 5882 individuals bd across multiple sites statistical approach consisted systematic uniform application analyses across sites site performed logistic regression analysis empirically derived higher versus lower function dependent variable selected clinical demographic variables predictors found high rates functional impairment ranging 41 75 lower community functioning associated depressive symptoms 10 12 cohorts included variable analysis lower levels education greater number prior mood episodes presence comorbid substance use disorder greater total number psychotropic medications also associated low functioning bipolar clinical research community poised work together characterize multidimensional contributors impairment address barriers impede patients complete recovery must also identify core features enable many thrive live successfully bd largescale worldwide prospective longitudinal study focused squarely bd heterogeneous presentations serve platform discovery promote major advances toward optimizing outcomes every individual illnessreprinted bipolar disord 2022 24709719 permission john wiley sons copyright 2022