Wolnei Caumo|Luciana da Conceição Antunes|Jéssica Lorenzzi Elkfury|Evelyn Grabin Herbstrith|Raquel Busanello Sipmann|Andressa de Souza|Iraci Lucena da Silva Torres|Vinícius Souza dos Santos|Randy Neblett
The Central Sensitization Inventory validated and adapted for a Brazilian population: psychometric properties and its relationship with brain-derived neurotrophic factor
Pontifícia Universidade Católica do Rio Grande do Sul|Universidade Federal do Rio Grande do Sul|Universidade La Salle|Health and Human Development (2HD) Research Network|Universidade Federal do Rio Grande do Sul|Productive Rehabilitation Institute of Dallas for Ergonomics
primary aim assess psychometric properties including internal consistency construct validity reproducibility factor structure central sensitization inventory csi adapted validated brazilian population csibp additionally evaluated relationship csibp serum brainderived neurotrophic factor bdnf determined symptoms elicited csibp discriminate subjects dodo respond conditioned pain modulation cpm task assessed change numeric pain scale 010 scorea crosssectional study conducted pain clinic tertiary teaching hospital total 222 adults chronic musculoskeletal pain 63 healthy control subjects completed csibp brazilian portuguese paincatastrophizing scale bppcs team experts translated csi according international guidelines testretest item analysis convergent validity factor analysis performed later random subsample n77 used correlate csibp adjusted index change numeric painscale score cpm task bdnf blood samplethe csibp presented strong psychometric properties testretest reliability 091 cronbachs 091 confirmatory factor analysis yielded fourfactor structure supporting original english version csibp adjusted index showed moderate positive correlation bppcs classified 80 patients correctly vs healthy controls serum bdnf levels explained 27 variation csibp adjusted index subjects impairment descending modulatory system higher csibp adjusted index scores subjects responded normally cpm task 4935 121 vs 395 1233 respectively p005the csibp found psychometrically strong reliable instrument primary evidence validity higher scores csibp correlated positively serum bdnf greater dysfunction descending painmodulatory system