Xin Wang, Weiqiu Cheng, Jin Zhu, Hongtao Yin, Suhua Chang, Weihua Yue, Hao Yu
Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder
Journal of affective disorders
interindividual variability gross motor development infants substantial challenges interpretation motor assessments longitudinal research provide insight variability individual gross motor trajectories model gross motor growth curve healthy termborn infants 35 155 months alberta infant motor scale aims explore groups infants different patterns development prospective longitudinal study including six assessments aims linear mixed model analysis lmm applied model motor growth controlled covariates cluster analysis used explore groups different pathways growth curves subgroups modelled differences covariates groups described tested total data 103 infants included lmm showed cubic function f1571 8968 p 0001 fitted data best none covariates remained model cluster analysis delineated three clinically relevant groups 1 early developers 32 2 gradual developers 46 3 late bloomers 22 significant differences covariates groups found birth order maternal education maternal employment current study contributes knowledge gross motor trajectories healthy term born infants cluster analysis identified three groups different gross motor trajectories motor growth curve provides starting point future research motor trajectories infants risk contribute accurate screening