Marianne Hope Abel|Ida Henriette Caspersen|Helle Margrete Meltzer|Margaretha Haugen|Ragnhild Eek Brandlistuen|Heidi Aase|Jan Alexander|Liv Elin Torheim|Anne Lise Brantsæter
Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study
OsloMet – Oslo Metropolitan University|Norwegian Institute of Public Health|Tine (Norway)|Norwegian Institute of Public Health|Norwegian Institute of Public Health|Norwegian Institute of Public Health|Norwegian Institute of Public Health|Norwegian Institute of Public Health|Norwegian Institute of Public Health|OsloMet – Oslo Metropolitan University|Norwegian Institute of Public Health
background severe iodine deficiency pregnancy major effects child neurodevelopment less known potential consequences mildtomoderate deficiency iodine supplement useobjective explored associations maternal iodine intake child neurodevelopment 3 age potential impact maternal intake iodine supplements outcomesmethods populationbased prospective observational study included 48297 motherchild pairs recruited pregnancy 2002 2008 maternal iodine intake calculated based validated foodfrequency questionnaire answered midpregnancy covered mean intake since beginning pregnancy associations iodine intake maternalreported child language motor development behavior problems explored multivariable regression analysesresults 33047 motherchild pairs excluding iodine supplement users maternal iodine intake associated child language delay p 0024 externalizing internalizing behavior problems p 0001 fine motor skills p 0002 gross motor skills risk walking unaided 17 mo age 74 participants iodine intake 160 gd estimated average requirement suboptimal iodine intake estimated account 5 95 ci 5 14 cases language delay 16 95 ci 0 21 cases externalizing behavior problems 15 sd 16 95 ci 10 21 cases internalizing behavior problems 15 sd 48297 motherchild pairs including iodine supplement users found protective effects supplemental iodine pregnancy neurodevelopmentconclusions maternal iodine intake estimated average requirement pregnancy associated symptoms child language delay behavior problems reduced fine motor skills 3 age results showed evidence protective effect iodine supplementation pregnancy