Kushang V. Patel|Dagmar Amtmann|Mark P. Jensen|Shannon M. Smith|Christin Veasley|Dennis C. Turk
Clinical outcome assessment in clinical trials of chronic pain treatments
University of Washington|University of Washington|University of Washington|University of Rochester|University of Washington
abstract clinical outcome assessments coas measure outcomes meaningful patients clinical trials critical determining whether treatment effective objectives study 1 describe different types coas provide overview key considerations evaluating coas 2 review coas outcome measures chronic pain treatments recommended initiative methods measurement pain assessment clinical trials immpact expert groups 3 review advances understanding painrelated coas relevant clinical trials authors reviewed relevant articles chapters guidance documents european medicines agency us food drug administration since original core set outcome measures recommended immpact 14 years ago several new advancements publications relevant measurement interpretation coas chronic pain trials emerged presenting new research opportunities despite progress quality measurement several outcome domains clinical trials chronic pain remain measurement challenges require methodological investigation