Lilliana DeSantiago-Cardenas, Victoria Rivkina, Stephanie A Whyte, Blair C Harvey-Gintoft, Bryan J Bunning, Ruchi S Gupta
Emergency epinephrine use for food allergy reactions in Chicago Public Schools
American journal of preventive medicine
tracked consequences utero protein restriction mice throughout development life course using luciferasebased allelic reporter imprinted cdkn1c exposure gestational lowprotein diet lpd results inappropriate expression paternally inherited cdkn1c brains embryonic juvenile mice animals characterised developmental delay motor skills behavioural alterations indicative reduced anxiety exposure lpd utero resulted significantly tyrosine hydroxylase positive dopaminergic neurons midbrain adult offspring compared agematched controldiet equivalents positron emission tomography pet imaging revealed increase striatal dopamine synthesis capacity lpdexposed offspring elevated levels dopamine correlated enhanced sensitivity cocaine data highlight profound sensitivity developing epigenome gestational protein restriction data also suggest loss cdkn1c imprinting p57kip2 upregulation alters cellular composition developing midbrain compromises dopamine circuitry thereby provokes behavioural abnormalities early postnatal life molecular analyses showed despite phenotype exposure lpd solely pregnancy significantly change expression key neuronal dopamineassociated marker genes adult offspring