Leigh M. Howard|José A. Tique|Sandra Gaveta|Mohsin Sidat|Russell L. Rothman|Sten H. Vermund|Philip J. Ciampa
Health literacy predicts pediatric dosing accuracy for liquid zidovudine
Vanderbilt University|Friends United|Eduardo Mondlane University|Eduardo Mondlane University|Beth Israel Deaconess Medical Center|Vanderbilt University
little known adult caregivers ability accurately dose pediatric antiretroviral medications aimed characterize frequency dosing errors liquid zidovudine using two dosing devices evaluate association hiv literacy dosing errors adults living hiv infectioncrosssectional study enrolling 316 adults receiving combination antiretroviral therapy cart hiv infection maputo province mozambiqueparticipants administered hiv literacy test hivlt asked measure 25 ml liquid zidovudine using cup syringe dosing measurement errors liquid zidovudine defined error 20 deviation reference dose major error 40 deviation reference dosedosing errors common using cup error 50 major error 28 syringe error 48 participants major error 28 significant differences proportions dosing error p061 major dosing errors p082 dosing instruments multivariable models associations p 003 found higher hivlt score dosing errors cup error adjusted odds ratio aor 091 084099 major error aor 084 075092 syringe error aor 082 075090 major error aor 088 080097liquid antiretroviral medications critical prevention treatment pediatric hiv infections yet dosing errors exceedingly common population significantly associated lower hiv literacy levels targeted interventions needed improve hiv knowledge skills pediatric medication dosing particularly caregivers limited literacy