Gerald M Fried, Julián Varas, Dana A Telem, Caprice C Greenberg, Daniel A Hashimoto, John T Paige, Carla Pugh
Opportunities and Applications of Educational Technologies in Surgical Education and Assessment
Annals of surgery
singapore population aging rising life expectancy increasing herpes zoster hz burden may reduced vaccination present study modeled public health impact hz vaccination singapore using zoster economic analysis zona model adapted singaporespecific key model inputs available base case analysis conducted adults 50 years age yoa exploring three vaccination strategies vaccination recombinant zoster vaccine rzv zoster vaccine live zvl mass vaccination setting 30 coverage scenario sensitivity analyses performed 151 million adults 2021 base case population 406513 270 cases hz 68264 45 cases postherpetic neuralgia phn 54949 36 cases complications projected without vaccination rzv estimated avoid 73129 cases hz 11094 cases phn 9205 cases complications subjects remaining lifetime zvl would avoid 17565 cases hz 2781 cases phn 1834 cases complications number needed vaccinate prevent one case hzphn lower rzv 741 zvl 26163 among five agestratified cohorts 505960646569707980 yoa rzv versus vaccinationzvl avoided largest number cases youngest cohort 5059 yoa results robust scenario sensitivity analyses mass vaccination rzv expected greatly reduce public health burden hz among singapore individuals 50 yoa findings support value assessment decisionmaking regarding public health vaccination strategies hz prevention singapore