Xiaoyu Yin, Marcy Richardson, Andreas Laner, Xuemei Shi, Elisabet Ognedal, Valeria Vasta, Thomas V O Hansen, Marta Pineda, Deborah Ritter, Johan T den Dunnen, Emadeldin Hassanin, Wencong Lyman Lin, Ester Borras, Karl Krahn, Margareta Nordling, Alexandra Martins, Khalid Mahmood, Emily A W Nadeau, Victoria Beshay, Carli Tops, Maurizio Genuardi, Tina Pesaran, Ian M Frayling, Gabriel Capellá, Andrew Latchford, Sean V Tavtigian, Carlo Maj, Sharon E Plon, Marc S Greenblatt, Finlay A Macrae, Isabel Spier, Stefan Aretz
Systematic large-scale application of ClinGen InSiGHT APC -specific ACMG/AMP variant classification criteria substantially alleviates the burden of variants of uncertain significance in ClinVar and LOVD databases
medRxiv : the preprint server for health sciences
fear childbirth foc influence maternal child health research foc china scarce especially rural women study aimed assess pre postpartum foc predictors among chinese rural women prospective correlation study total 569 women completed prenatal questionnaire third trimester 477 completed postpartum questionnaire within three days childbirth maternal sociodemographic information clinical information childbirth selfefficacy prenatal postpartum foc investigated foc evaluated using wijma childbirth expectancy experience questionnaire wdeq descriptive bivariate multivariate linear regression analysis univariate multivariate logistic regression analyses performed mean pre postpartum foc scores 645 standard deviation 251 643 standard deviation 239 respectively 208 women reporting severe fear childbirth 182 childbirth multivariate linear regression analysis revealed predictors higher levels prenatal foc including higher education level nullipara higher monthly household income lower family support lower childbirth selfefficacy p 005 predictors higher levels postpartum foc included unemployed status lower childbirth selfefficacy higher prenatal foc p 005 multivariate logistic regression showed higher childbirth selfefficacy reduced likelihood severe prenatal foc 099 p 0001 severe prenatal foc increased likelihood severe postpartum foc 357 p 0001 rural women high levels foc childbirth approximately 20 experiencing severe foc periods higher education level nullipara higher monthly household income lower family support lower childbirth selfefficacy predictors heightened prenatal foc unemployed status lower childbirth selfefficacy higher prenatal foc predictors heightened postpartum foc notably enhancing childbirth selfefficacy emerges crucial mitigating severe prenatal foc severe prenatal foc significantly increases likelihood severe postpartum foc development targeted intervention strategies factors help reduce womens foc level improve overall pregnancy childbirth experience