Brittany Lattanza, Divya Lakhaney, Theresa Scott, Ashley Croker-Benn, Mirna Giordano, Sumeet L Banker
Caring for Children With Medical Complexity: A Clinical, Patient-Focused Curriculum
MedEdPORTAL : the journal of teaching and learning resources
hyponatremia wellknown adverse event repeated therapy vincristine oncological patients however date data pediatric patients malignant diseases acute lymphoblastic leukemia sparse lacking retrospective study 98 pediatric patients conducted analyze incidence hyponatremia caucasian cohort newly diagnosed comparison examined five pediatric oncological cohorts hodgkins disease ewing sarcoma wilms tumor benign glioma cns langerhans cell histiocytosis receive alkaloids induction regimes found high incidence hyponatremia 147 cohort trend toward male patients elementary school age none affected patients showed neurological symptoms comparison patients malignancy groups show significant hyponatremia regardless comparable therapy alkaloids show noticeable coincidence hyponatremia hypertriglyceridemia patients indicating possible role lasparaginaserelated hypertriglyceridemia development severe hyponatremia patients report higher incidence hyponatremia following vincristine therapy caucasian children published hyponatremia could demonstrated oncologic cohorts treated alkaloids lasparaginaseinduced hypertriglyceridemia may play role certainly multifactorial development hyponatremia childhood leukemia