G. David Batty|Ian J. Deary|Paola Zaninotto
Association of Cognitive Function With Cause-Specific Mortality in Middle and Older Age: Follow-up of Participants in the English Longitudinal Study of Ageing
University College London|University College London|University College London
examined littletested associations general cognitive function middle older age later risk death chronic diseases english longitudinal study ageing 20022012 11391 study participants 50100 years age study induction underwent battery cognitive tests provided range collateral data analytical sample 9204 people 4982 women 1488 deaths followup mean duration 90 years combined scores 4 cognition tests represented 3 acknowledged key domains cognitive functioning memory executive function processing speed cognition inversely associated deaths cancer per 1standarddeviation decrease general cognitive function score hazard ratio 121 95 ci 110 133 cardiovascular disease hazard ratio 171 95 ci 155 189 causes hazard ratio 207 95 ci 179 240 respiratory illness hazard ratio 248 95 ci 212 290 controlling range covariates health behaviors socioeconomic status leftcensoring explore reverse causality little impact strength relationships findings indicate cognitive test scores provide relatively simple indicators risk death array chronic diseases associations appear independent commonly assessed risk factors