Andrew L Larsen, John J McArdle, Trina Robertson, Genevieve Dunton
Four Dietary Items of the School Physical Activity and Nutrition (SPAN) Questionnaire Form a Robust Latent Variable Measuring Healthy Eating Patterns
Journal of nutrition education and behavior
toxicological studies demonstrated hepatic toxicity several bisphenol analogs bps prevalent type endocrine disruptor development adverse outcome pathway aop substantially contributed rapid risk assessment human health however lack vitro vivo data emerging bps limited hazard assessment synthetic chemicals aimed develop new strategy rapidly predict bps hepatotoxicity using network analysis coupled machine learning models considering structural functional similarities shared bps bisphenol bpa first integrated hepatic disease related genes multiple databases bpagenephenotypehepatic toxicity network subjected computational aop caop caop network conventional machine learning approaches scored hepatotoxicity 20 emerging bps provided new insights bps structure features contributed biologic functions limited experimental data additionally assessed interactions emerging bps esr1 using molecular docking proposed aop framework wherein esr1 molecular initiating event overall study provides computational approach predict hepatotoxicity emerging bps