Brook E Harmon
Rethinking physical activity for children: implications for the working poor
Translational behavioral medicine
sensitivity analysis widely applied study biological systems including metabolic networks signalling pathways genetic circuits morris method kind screening sensitivity analysis approach fast identify key factors numerous biological parameters inputs parameter input space randomly sampled produce limited number trajectories calculation elementary effects clear sampled trajectories enough cover whole uncertain space eventually causes unstable sensitivity measures paper presents novel trajectory optimisation algorithm morrisbased sensitivity calculation ensure good scan throughout whole uncertain space paper demonstrates presented method gets consistent sensitivity results benchmark example application previously published ordinary differential equation model cellular signalling network presented detail parameter sensitivity analysis verifies good agreement data literatures