Gopisankar Mohanannair Geethadevi, Terry J Quinn, Johnson George, Kaarin J Anstey, J Simon Bell, Muhammad Rehan Sarwar, Amanda J Cross
Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia
The Cochrane database of systematic reviews
activitydependent alteration synaptic strength fundamental property vertebrate central nervous system thought underlie learning memory extensively studied model activitydependent synaptic plasticity longterm potentiation ltp glutamateresponsive glutamatergic synapses widespread phenomenon involving multiple mechanisms best characterized form ltp occurs ca1 region hippocampus ltp initiated transient activation nmda nmethyldaspartate receptors expressed persistent increase synaptic transmission ampa alphaamino3hydroxy5methyl4isoxazolepropionate receptors increase due least part postsynaptic modification ampareceptor function modification could caused increase number receptors open probability kinetics singlechannel conductance show induction ltp ca1 region hippocampus often associated increase singlechannel conductance ampa receptors shows elementary channel properties rapidly modified synaptic activity provides insight one molecular mechanism glutamatergic synapses alter strength