Rosian Tossaint-Schoenmakers, Marise J Kasteleyn, Anneloek Rauwerdink, Niels Chavannes, Sofie Willems, Esther P W A Talboom-Kamp
Development of a Quality Management Model and Self-assessment Questionnaire for Hybrid Health Care: Concept Mapping Study
JMIR formative research
study undertaken characterize quantitative electroencephalographic eeg features participants natural history study rtt related disorders assess potential features act objective measures cortical function rett syndrome rtt eeg amplitude power features derived resting eeg 60 females rtt median age 107 years 26 neurotypical females median age 106 years analyses focus group differences within rtt group associations eeg parameters clinical severity subset participants n 20 followup data available assessing reproducibility results stability parameters 1 year compared neurotypical participants participants rtt greater amplitude variability greater lowfrequency activity reflected greater delta power negative 1f slope lower thetadelta alphadelta betadelta alphatheta betatheta ratios greater delta power negative 1f slope lower power ratios associated greater severity analyses year 1 data replicated associations 1f slope power ratios clinical severity demonstrated good withinsubject consistency measures overall group comparisons reflected greater predominance lower versus higher frequency activity participants rtt consistent prior clinical interpretations resting eeg population observed associations eeg power measures clinical assessments repeatability measures underscore potential eeg provide objective measure cortical function clinical severity rtt ann neurol 2024