Katherine Bristowe, Liadh Timmins, Alexandra Pitman, Debbie Braybrook, Steve Marshall, Katherine Johnson, Michael King, Anna Roach, Deokhee Yi, Kathryn Almack, Elizabeth Day, Paul Clift, Ruth Rose, Richard Harding
Between loss and restoration: The role of liminality in advancing theories of grief and bereavement
Social science & medicine (1982)
complex phenotypes many common diseases morphological traits controlled multiple genetic factors namely genetic mutations genes influenced environmental conditions deciphering genetics underlying traits requires systemic approach many different genetic factors interactions considered simultaneously many association mapping techniques available nowadays follow reasoning severe limitations particular require binary encodings genetic markers forcing user decide beforehand whether use eg recessive dominant encoding moreover methods cannot include biological prior limited testing lowerorder interactions among genes association phenotype potentially missing large number marker combinations propose hogimine novel algorithm expands class discoverable genetic metamarkers considering higherorder interactions genes allowing multiple encodings genetic variants experimental evaluation shows algorithm substantially higher statistical power compared previous methods allowing discover genetic mutations statistically associated phenotype hand could found method exploit prior biological knowledge gene interactions proteinprotein interaction networks genetic pathways protein complexes restrict search space since computing higherorder gene interactions poses high computational burden also develop efficient search strategy support computation make approach applicable practice leading substantial runtime improvements compared stateoftheart methods code data available httpsgithubcomborgwardtlabhogimine