Dídac Vidal-Piñeiro|Pablo Martín-Trias|Eider M. Arenaza?Urquijo|Roser Sala?Llonch|Imma C. Clemente|Isaias Mena-Sánchez|Núria Bargalló|Carles Falcón|Álvaro Pascual?Leone|David Bartrés?Faz
Task-dependent Activity and Connectivity Predict Episodic Memory Network-based Responses to Brain Stimulation in Healthy Aging
Universitat de Barcelona|Universitat de Barcelona|Universitat de Barcelona|Universitat de Barcelona|Universitat de Barcelona|Universitat de Barcelona|Consorci Institut D'Investigacions Biomediques August Pi I Sunyer|Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine|Consorci Institut D'Investigacions Biomediques August Pi I Sunyer|Institut Guttmann|Berenson Allen Center for Noninvasive Brain Stimulation|Beth Israel Deaconess Medical Center|Consorci Institut D'Investigacions Biomediques August Pi I Sunyer|Universitat de Barcelona
background transcranial magnetic stimulation tms affect episodic memory one main cognitive hallmarks aging mechanisms action remain unclear objectives evaluate behavioral functional impact excitatory tms group healthy elders methods applied paradigm repetitive tms intermittent thetaburst stimulation left inferior frontal gyrus healthy elders n 24 evaluated impact performance episodic memory task two levels processing associated brain activity captured pre post fmri scans results posttms fmri found tmsrelated activity increases left prefrontal cerebellumoccipital areas specifically deep encoding shallow encoding rest furthermore found taskdependent change connectivity encoding task cerebellumoccipital areas tmstargeted left inferior frontal region connectivity change correlated tms effects brain networks conclusions results suggest aged brain responds brain stimulation statedependent manner engaged different tasks components tms effect related interindividual connectivity changes measures findings reveal fundamental insights brain network dynamics aging capacity probe combined behavioral stimulation approaches