Thirumalini Selvaraj, Gianni Gallello, Ashna Mehra, Kunal Rungta, Baskar Jaganathan, Mirco Ramacciotti, Agustín Pastor, Simona Raneri
Rare earth elements sediment analysis tracing anthropogenic activities in the stratigraphic sequence of Alagankulam (India)
Heliyon
medullary thyroid carcinoma mtc positive findings lateral neck surgery whether prophylactic lateral neck dissection lnd needed remains controversial better way predict occult metastasis lateral neck needed january 2010 january 2022 patients diagnosed mtc underwent primary surgery hospital retrospectively reviewed collected patients baseline characteristics surgical procedure rescored ultrasound images primary lesions using american college radiology acr thyroid imaging reporting data system tirads regularized logistic regression 5fold crossvalidation decision curve analysis applied lateral lymph node metastasis llnm models development validation tested predictive ability llnm model occult llnm cn01a patients total 218 patients enrolled five baseline characteristics two tirads features identified highrisk factors llnm gender baseline calcitonin ctn tumor size multifocality central lymph node cln status well tirads margin level llnm model developed showed good discrimination 5fold crossvalidation mean area curve auc 092 003 test dataset among cn01a patients llnm model achieved auc 091 95 ci 088094 predicting occult llnm significantly higher aucs baseline ctn 083 cln status 064 developed llnm prediction model mtc using machine learning based clinical baseline characteristics tirads model predict occult llnm cn01a patients accurately benefit decision prophylactic lnd