Tomoyuki Sakai, Yasuyuki Nomura, Toshihiro Sawai, Riku Hamada, Yoshimitsu Gotoh, Kazuna Yamamoto, Satoko Ichioka, Toshiki Masuda, Yoshihiro Maruo, Masataka Honda
Uptake of further investigations following universal urinary screening among elementary and junior high school students in Shiga Prefecture, Japan: A retrospective cohort study
Nephrology (Carlton, Vic.)
residents longterm care facilities ltcfs high risk morbidity mortality due covid19 especially new variants concern voc emerge provide intradisciplinary data order tailor public health interventions future epidemics available epidemiologic genomic data slovenian ltcfs initial phases covid19 pandemic analyzed first part study included sarscov2 reversetranscription realtime pcr rtrtpcr positive ltcf residents 21 facilities covid19 outbreaks occurring october 2020 second part study included sarscov2 rtrtpcr positive ltcf residents staff january april 2021 voc alpha emerged slovenia nextgeneration sequencing ngs used acquire sarscov2 genomes lineage determination indepth phylogenetic mutational profile analysis performed coupled available field epidemiological data assess dynamics sarscov2 introduction transmission 370498 sarscov2 positive residents well 558699 sarscov2 positive residents 301358 staff successfully sequenced first second part study respectively october 2020 covid19 outbreaks 21 ltcfs caused intrafacility transmission well multiple independent sarscov2 introductions alpha variant confirmed first ltcf resident approximately 15 months first alpha case identified slovenia data also showed slower replacement existing variants alpha residents compared staff general population multiple sars cov2 introductions well intrafacility spreading impacted disease transmission slovenian ltcfs timely implementation control measures aimed limiting new introductions controlling infacility transmission paramount importance especially new vocs emerge sequencing conjunction epidemiological data facilitate determination need future improvements control measures protect ltcf residents covid19 respiratory infections