Polly Duncan|Mairead Murphy|Mei?See Man|Katherine Chaplin|Daisy Gaunt|Chris Salisbury
Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ)
University of Bristol|University of Bristol|University of Bristol|University of Bristol|University of Bristol
objective develop validate new scale assess treatment burden effort looking ones health patients multimorbidity design mixedmethods setting uk primary care participants content multimorbidity treatment burden questionnaire mtbq based literature review views patient public involvement group face validity assessed cognitive interviews scale piloted final version tested 1546 adults multimorbidity mean age 71 years took part 3d study cluster randomised controlled trial question examined proportion missing data distribution responses factor analysis cronbachs alpha spearmans rank correlations longitudinal regression assessed dimensional structure internal consistency reliability construct validity responsiveness respectively assessed interpretability grouping global mtbq scores zero tertiles gt0 comparing participant characteristics across categories results cognitive interviews found good acceptability content validity factor analysis supported onefactor solution cronbachs alpha 083 indicating internal consistency reliability mtbq score positive association comparator treatment burden scale r 058 plt00001 selfreported disease burden r 043 plt00001 negative association quality life r 036 plt00001 selfrated health r 036 plt00001 female participants younger participants participants mental health conditions likely high treatment burden scores changes mtbq score 9month followup associated expected changes measures quality life euroqol five dimensions five level questionnaire patientcentred care patient assessment chronic illness care conclusion mtbq 10item measure treatment burden patients multimorbidity demonstrated good content validity construct validity reliability responsiveness useful research tool assessing impact interventions treatment burden trial registration number nct06180958