Codi White, Dianne C Shanley, Melanie J Zimmer-Gembeck, Katrina Lines, Kerryann Walsh, Russell Hawkins
Cluster randomised-control trial for an Australian child protection education program: Study protocol for the Learn to be safe with Emmy and friends™
BMC public health
investigated effects central review interim fluorodeoxyglucosepositron emission tomographycomputed tomography fdgpetct scan response ipet assessment treatment allocation riskbased responseadapted childrens oncology group study ahod1331 clinicaltrialsgov identifier nct02166463 pediatric patients highrisk hodgkin lymphoma per protocol 2 cycles systemic therapy patients underwent ipet visual response assessment 5point deauville score ds treating institution realtime central review latter considered reference standard area disease ds 1 3 considered rapidresponding lesion whereas ds 4 5 considered slowresponding lesion srl patients 1 srls considered ipet positive whereas patients rapidresponding lesions considered ipet negative conducted predefined exploratory evaluation concordance ipet response assessment institutional central reviews 573 patients concordance rate evaluated using cohen statistic 080 considered good agreement 060080 good agreement concordance rate 514 573 897 0685 95 ci 06100759 consistent good agreement terms direction discordance among 126 patients considered ipet positive institutional review 38 302 categorized ipet negative central review preventing overtreatment radiation therapy conversely among 447 patients considered ipet negative institutional review 21 patients 47 categorized ipet positive central review would undertreated without radiation therapy central review integral pet responseadapted clinical trials children hodgkin lymphoma continued support central imaging review education ds needed