Marie C L Sørensen, Mie M Andersen, Klaus Rostgaard, Kjeld Schmiegelow, Torben S Mikkelsen, Peder S Wehner, Marianne Olsen, Signe H Søegaard, Lisa L Hjalgrim
Treatment-related mortality among children with cancer in Denmark during 2001-2021
Acta oncologica (Stockholm, Sweden)
fluoroquinolones fqs distinct class antibiotics prescribed used quite frequently worldwide despite box warnings bw issued food drug administration fda literature shown spite bws related fqs minimal impact health care professionals hcps prescribing habits potentially attributing towards limited insufficient awareness pakistan fqs mostly prescribed antibiotics microbial treatments therefore purpose study determine level knowledge safety profile use bw fqs among hcps working pakistan crosssectional study undertaken among hcps khyber pakhtunkhwa province pakistan october 2022 december 2022 validated questionnaire used assess knowledge hcps regarding fqs safety profile bw random convenient sample technique used recruiting hcps study hcps comprised physicians dentists pharmacist nurses approached person study objective fully elaborated explained statistic test like oneway anova independentt test multivariate logistic regression used keeping pvalue 005 statistically significant total n 250 hcps approached n 186 hcps completed questionnaire response rate 744 fqs prescribing pattern assessed among prescribers ie physicians dentists 39186 mean knowledge score indications 529 305 adverse effects 770 261 highest score knowledge indications adverse effect score achieved physicians followed dentist mean knowledge score bw 346 293 among hcps bw fqs 204 hcps appropriate knowledge score score 50 knowledge score significantly higher males p 0039 dentists p 0001 hcps masterspecialization level education p 0003 hcps working government sector hospitals p 0010 secondary care hospitals p 0001 multivariate logistic regression analysis showed hcps working primary care hospital 62 secondary care hospital 203 associated tendency achieve 50 knowledge score findings study reveals unsatisfactory knowledge hcps regarding safety profile use bw fqs putting patients heightened risks fqs associated aes therefore crucial implement national antimicrobial stewardship program seminars lectures aimed continuously updating knowledge hcps regardless specialties effectively restrict misuse antimicrobial disseminate fda bws clinical practice