K. Darvin|Adam Randolph|S. Ovalles|Dipti G. Halade|L Breeding|Arlan Richardson|Sara Espinoza
Plasma Protein Biomarkers of the Geriatric Syndrome of Frailty
South Texas Veterans Health Care System|The University of Texas Health Science Center at San Antonio|The University of Texas Health Science Center at Houston|The University of Texas Health Science Center at San Antonio|The University of Texas Health Science Center at Houston
frailty geriatric syndrome associated physical decline aging using proteomicsbased screening method screen plasma potential biomarkers previously found inflammatory glycoproteins increased frailty purpose study confirm plasma levels glycoproteins well interleukin6 increased frailty larger sample n 65 communitydwelling older adults plasma levels transferrin fibrinogen haptoglobin interleukin6 determined enzymelinked immunosorbent assay differences protein concentrations frailty status determined using analysis variance higher levels transferrin p 001 fibrinogen p 0001 interleukin6 p 0035 associated frailty status nonfrail prefrail frail frailty score 05 sample even adjustment age sex haptoglobin differ frailty status p 05 findings largely confirmed findings nontargeted approach inflammatory glycoproteins increased frailty future studies include larger examinations associations consider potential usefulness glycoproteins biomarkers frailty