Clareci Silva Cardoso|Antônio Luiz Pinho Ribeiro|Cláudia Di Lorenzo Oliveira|Léa Campos de Oliveira|Ariela Mota Ferreira|Ana Luiza Bierrenbach|José Luiz Padilha Silva|Enrico A. Colosimo|João Eduardo Ferreira|Tzong Hae Lee|Michael P. Busch|Arthur Reingold|Éster Cerdeira Sabino
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study
Federal University of São João del-Rei|Hospital das Clínicas da Universidade Federal de Minas Gerais|Federal University of São João del-Rei|Universidade de São Paulo|Universidade Estadual de Montes Claros|Hospital Sírio-Libanês|Universidade Federal do Paraná|Hospital das Clínicas da Universidade Federal de Minas Gerais|Universidade de São Paulo|Blood Systems Research Institute|University of California, San Francisco|Blood Systems Research Institute|University of California, San Francisco|University of California, Berkeley|Universidade de São Paulo
effectiveness antiparasite treatment benznidazole chronic chagas disease chd remains uncertain evaluated using data nihsponsored samitrop prospective cohort study previous treatment benznidazole associated lower mortality less advanced cardiac disease lower parasitemia patients chronic chdthe study enrolled 1959 chd patients abnormal electrocardiogram ecg 21 remote towns brazil total 1813 patients evaluated baseline two years followup received least one course benznidazole classified treated group trg 493 never treated control group cg 1320 primary outcome death twoyear followup secondary outcomes presence baseline major chdassociated ecg abnormalities ntprobnp levels suggestive heart failure pcr positivitymortality two years 63 lower trg 28 cg 76 adjusted 037 95ci 021063 ecg abnormalities typical chd high ageadjusted ntprobnp levels suggestive heart failure lower trg cg 035 ci 023053 trg significantly lower rates pcr positivity 035 ci 027045patients previously treated benznidazole significantly reduced parasitemia lower prevalence markers severe cardiomyopathy lower mortality two years followup used early phases benznidazole treatment may improve clinical parasitological outcomes patients chronic chdclinicaltrialsgov trial registration nct02646943