Joseph A. Ross
Predicting and classifying effects of insertion and deletion mutations on protein coding regions
California State University, Fresno
mutations genes affect encoded proteins multiple ways effects counterintuitive knowledge students must create deep understanding central dogma students may develop understanding limited opportunity practice manipulating dna sequences classifying effects practice improve student appreciation myriad possible effects dna change mutation amino acid sequence lesson series scaffolded exercises provides opportunity students first identify gene sequences online database create insertiondeletion mutations predict effects students use webbased tool translate observe effect mutation protein sequence subsequent comparison predicted observed effects employs chisquare test discussion results peers involves categorizing types possible effects lesson concludes exercise asking students create mutation intended effect protein together exercises integrate quantitative reasoning statistical analysis information literacy multiple bloom39s learning levels student progress monitored using three formative three summative assessments