Diane B McNaughton, Julia Muennich Cowell, Louis Fogg
Efficacy of a Latino mother-child communication intervention in elementary schools
The Journal of school nursing : the official publication of the National Association of School Nurses
treatment planning diagnostic dimension theranostics provides insights predicting absorbed dose rpt potential individualize radiation doses enhancing treatment efficacy however existing studies focusing dose prediction diagnostic data often rely organlevel estimations overlooking intraorgan variations study aims characterize intraorgan theranostic heterogeneity utilize artificial intelligence techniques localize ie predict voxelwise absorbed dose map based pretherapy pet 23 patients metastatic castrationresistant prostate cancer treated 177lulupsma rpt retrospectively included 48 treatment cycles pretreatment pet imaging least 3 posttherapeutic spectct imaging selected distribution pet tracer rpt dose compared kidney liver spleen characterizing intraorgan heterogeneity differences pharmacokinetic simulations performed enhance understanding correlation two strategies explored pretherapy voxelwise dosimetry prediction 1 organdose guided direct projection 2 deep learning dlbased distribution prediction physical metrics dose volume histogram dvh analysis identity plots applied investigate predicted absorbed dose map inconsistent intraorgan patterns emerged pet imaging dose map moderate correlations existing kidney r 077 liver r 05 spleen r 058 p 0025 simulation results indicated intraorgan pharmacokinetic heterogeneity might explain inconsistency dlbased method achieved lower average voxelwise normalized root mean squared error 079 027 regarding groundtruth dose map outperforming organdose guided projection 111 057 p 005 dvh analysis demonstrated good prediction accuracy r2 092 kidney dl model improved mean slope fitting lines identity plots 199 liver compared theoretical optimal results organdose approach results demonstrated intraorgan heterogeneity pharmacokinetics may complicate pretherapy dosimetry prediction dl potential bridge gap pretherapy prediction voxelwise heterogeneous dose map