Susanna Hedenborg, Mathilde Kronborg, Anna Sätre, Aage Radmann, Gabriella Torell Palmquist, Petra Andersson
Pro-Environmental Transformation of the Equine Sector-Facilitators and Challenges
Animals : an open access journal from MDPI
genetic effects sexspecific particularly traits testosterone sex hormone sexstratified analysis provides easily interpretable sexspecific effect size estimates presence sexdifferences snp effect implies snpsex interaction suggests usage often overlooked joint test testing snps main snpsex interaction effects simultaneously notably even without individuallevel data joint test statistic derived sexstratified summary statistics omnibus metaanalysis utilizing available sexstratified summary statistics uk biobank performed omnibus metaanalyses 290 quantitative traits results revealed approach robust genetic effect heterogeneity outperform traditional sexstratified sexcombined main effectonly tests therefore advocate using omnibus metaanalysis captures main interaction effects subsequent sexstratified analysis conducted sexspecific effect size estimation interpretation