H.J.G. Abrahams|Marieke Gielissen|Rogier Donders|Martine M. Goedendorp|Agnes J. van der Wouw|C.A.H.H.V.M. Verhagen|Hans Knoop
The efficacy of Internet?based cognitive behavioral therapy for severely fatigued survivors of breast cancer compared with care as usual: A randomized controlled trial
Amsterdam UMC Location VUmc|Radboud University Nijmegen|Radboud University Medical Center|University of Amsterdam|Academic Medical Center|Radboud University Nijmegen|Radboud University Medical Center|University Medical Center Groningen|University of Groningen|VieCuri Medisch Centrum|Radboud University Medical Center|Radboud University Nijmegen|Amsterdam UMC Location VUmc|University of Amsterdam|Academic Medical Center
severe fatigue common distressing symptom affecting approximately one four survivors breast cancer current study examined efficacy internetbased cognitive behavioral therapy icbt severe fatigue survivors breast cancer compared care usual cauthe authors conducted parallelgroup randomized controlled trial severely fatigued diseasefree survivors breast cancer completed cancer treatment least 3 months previously eligible participants randomly allocated icbt cau using computergenerated stratified block randomization primary outcome fatigue severity assessed baseline 6 months secondary outcomes functional impairment psychological distress quality life statistical effects tested analyses covariance intentiontotreat analysisparticipants recruited january 2014 march 2016 assigned icbt 66 patients cau 66 patients compared participants received cau received icbt reported lower fatigue scores 6 months mean difference 115 95 confidence interval 95 ci 77153 large effect size cohen 10 majority patients 73 demonstrating clinically significant improvement icbt also found lead lower functional impairment 2978 95 ci 14554501 psychological distress scores 57 95 ci 3479 higher qualityoflife scores 117 95 ci 58177 compared cau medium large effect sizes cohen 0608icbt appears effective reducing severe fatigue related symptoms meets current need easy accessible efficient evidencebased treatment options severely fatigued survivors breast cancer cancer 2017123382534 2017 american cancer society