María Jesús Broch Porcar, Álvaro Castellanos-Ortega
Patient safety, what does clinical simulation and teaching innovation contribute?
Medicina intensiva
whether exposure air pollution adversely affects growth lung function period rapid lung development occurs ages 10 18 years unknownin prospective study recruited 1759 children average age 10 years schools 12 southern california communities measured lung function annually eight years rate attrition approximately 10 percent per year communities represented wide range ambient exposures ozone acid vapor nitrogen dioxide particulate matter linear regression used examine relationship air pollution forced expiratory volume one second fev1 spirometric measuresover eightyear period deficits growth fev1 associated exposure nitrogen dioxide p0005 acid vapor p0004 particulate matter aerodynamic diameter less 25 microm pm25 p004 elemental carbon p0007 even adjustment several potential confounders effect modifiers associations also observed spirometric measures exposure pollutants associated clinically statistically significant deficits fev1 attained age 18 years example estimated proportion 18yearold subjects low fev1 defined ratio observed expected fev1 less 80 percent 49 times great highest level exposure pm25 lowest level exposure 79 percent vs 16 percent p0002the results study indicate current levels air pollution chronic adverse effects lung development children age 10 18 years leading clinically significant deficits attained fev1 children reach adulthood