Nicole E. Neef|Bent Müller|Johanna Liebig|Gesa Schaadt|Maren Grigutsch|Thomas C. Gunter|Arndt Wilcke|Holger Kirsten|Michael Skeide|Indra Kraft|Nina Kraus|Frank Emmrich|Jens Bräuer|Johannes Boltze|Angela D. Friederici
Dyslexia risk gene relates to representation of sound in the auditory brainstem
Max Planck Institute for Human Cognitive and Brain Sciences|Fraunhofer Institute for Cell Therapy and Immunology|Max Planck Institute for Human Cognitive and Brain Sciences|Humboldt-Universität zu Berlin|Max Planck Institute for Human Cognitive and Brain Sciences|Max Planck Institute for Human Cognitive and Brain Sciences|Max Planck Institute for Human Cognitive and Brain Sciences|Fraunhofer Institute for Cell Therapy and Immunology|Leipzig University|Fraunhofer Institute for Cell Therapy and Immunology|Max Planck Institute for Human Cognitive and Brain Sciences|Max Planck Institute for Human Cognitive and Brain Sciences|Northwestern University|Fraunhofer Institute for Cell Therapy and Immunology|Max Planck Institute for Human Cognitive and Brain Sciences|Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering|University of Lübeck|Fraunhofer Institute for Cell Therapy and Immunology|Max Planck Institute for Human Cognitive and Brain Sciences
dyslexia reading disorder strong associations kiaa0319 dcdc2 genes play functional role spike time precision neurons strikingly poor readers show imprecise encoding fast transients speech auditory brainstem whether dyslexia risk genes related quality sound encoding auditory brainstem remains investigated quantified response consistency speechevoked brainstem responses acoustically presented syllable da 159 genotyped literate preliterate children controlling age sex familial risk intelligence partial correlation analyses associated higher dyslexia risk loading kiaa0319 noisier responses contrast higher risk loading dcdc2 associated trend towards stable responses results suggest unstable representation sound thus reduced neural discrimination ability stop consonants occurred genotypes carrying higher amount kiaa0319 risk alleles current data provide first evidence dyslexiaassociated gene kiaa0319 alter brainstem responses impair phoneme processing auditory brainstem braingene relationship provides insight complex relationships phenotype genotype thereby improving understanding dyslexiainherent complex multifactorial condition