Jennifer L. Hay|Marianne Berwick|Kate Zielaskowski|Kirsten A. White|Vivian M. Rodríguez|Erika Robers|Dolores D. Guest|Andrew L. Sussman|Yvonne Talamantes|Matthew Schwartz|Jennie Greb|Jessica Bigney|Kimberly A. Kaphingst|Keith Hunley|David B. Buller
Implementing an Internet-Delivered Skin Cancer Genetic Testing Intervention to Improve Sun Protection Behavior in a Diverse Population: Protocol for a Randomized Controlled Trial
Memorial Sloan Kettering Cancer Center|University of New Mexico|Memorial Sloan Kettering Cancer Center|University of New Mexico|The Center for Mind-Body Medicine|University of New Mexico|University of New Mexico|University of New Mexico|University of New Mexico|University of New Mexico|University of New Mexico|University of New Mexico|University of Utah|University of New Mexico|Klein Buendel (United States)
limited translational genomic research currently exists guide availability comprehension appropriate use personalized genomics diverse general population subgroups melanoma skin cancers preventable curable common general population disproportionately increasing hispanicsvariants melanocortin1 receptor mc1r gene present approximately 50 population major factors determining sun sensitivity confer 2to3fold increase melanoma risk general population even populations darker skin therefore feedback regarding mc1r risk status may raise risk awareness protective behavior general populationwe conducting randomized controlled trial examining internet presentation risks benefits personalized genomic testing mc1r gene variants associated increased melanoma risk enroll total 885 participants 462 participants currently enrolled randomized 61 personalized genomic testing melanoma risk versus waiting list control control participants offered testing outcome assessments participants balanced across selfreported hispanic versus nonhispanic ethnicity n750 personalized genomic testing melanoma risk arm n135 control arm recruited general population cohort albuquerque new mexico subject yearround sun exposure baseline surveys completed inperson study staff followup measures completed via telephoneaim 1 trial examine personal utility personalized genomic testing melanoma risk terms shortterm 3month sun protection skin screening behaviors family physician communication melanoma threat control beliefs ie putative mediators behavior change also examine potential unintended consequences testing among receive averagerisk personalized genomic testing melanoma risk findings examine predictors sun protection 3 months outcome findings used develop messages groups receive averagerisk feedback aim 2 compare rates test consideration hispanics versus nonhispanics including consideration testing pros cons registration decision either accept decline testing aim 3 examine personalized genomic testing melanoma risk feedback comprehension recall satisfaction cancerrelated distress undergo testing whether outcomes differ ethnicity hispanic vs nonhispanic sociocultural demographic factors final outcome data collection anticipated complete october 2017 point data analysis commencethis study important implications personalized genomics context melanoma risk may broadly applicable model delivery personalized genomic feedback health conditions