Christina Misunas, Erica Soler-Hampejsek, Beth Kangwana, Nicole A Haberland
Do adolescent girls' education and friendships have independent effects on early pregnancy? Results of a mediation analysis from a longitudinal cohort study in Nairobi, Kenya
SSM - population health
substantial focus placed atrial fibrillation af treatment associated stroke prevention rather preventing af employed mendelian randomization mr approach examine causal relationships 50 modifiable risk factors rfs af instrumental variables genetically predicted exposures derived corresponding genomewide association studies gwass summarylevel statistical data af obtained gwas metaanalysis discovery dataset n 1030836 finngen validation dataset n 208594 univariable multivariable mr analyses performed primarily using inverse variance weighted method series robust sensitivity analyses genetic predisposition insomnia daytime naps apnea smoking initiation moderate vigorous physical activity obesity traits including body mass index waisthip ratio central peripheral fatfatfree mass exhibited significant associations increased risk af coffee consumption apob suggestive increased risks hypertension odds ratio 95 confidence interval ci 526 442 624 heart failure hf 95 ci 477 243 937 coronary artery disease cad 95 ci 120 116 124 strongly associated af college degree higher education attachment hdl levels associated decreased af risk reverse mr found bidirectional relationship genetically predicted af cad hf ischemic stroke multivariable analysis indicated obesityrelated traits systolic blood pressure lower hdl levels independently contributed development af study identified several lifestyles cardiometabolic factors might causally related af underscoring importance holistic approach af management prevention