Sherry Bawa, Subramaniam Ananthram, Dawn Bennett, Subhadarsini Parida
Do STEM women feel ethically and emotionally better prepared for their careers than men?
Acta psychologica
argon ar proposed potential therapeutic agent multiple clinical conditions specifically organ protection however conflicting data preclinical models together great variability ar administration protocols outcome assessments reported aim study review evidence treatment ar extensive investigation neuroprotective effect summarise tested administration protocols using pubmed database existing preclinical clinical studies treatment ar systematically reviewed registration httpsdoiorg1017605osfio7983d study titles abstracts screened extracting data relevant studies post fulltext review exclusion criteria included absence full text nonenglish language furthermore metaanalysis also performed assess ar potential neuroprotectant agent different clinical conditions cardiac arrest traumatic brain injury ischemic stroke perinatal hypoxicischemic encephalopathy subarachnoid haemorrhage standardised mean differences neurological cognitive locomotor histological physiological measures evaluated appropriate tests clinical laboratory variables vivo studies evaluated risk bias using systematic review center laboratory animal experimentation tool vitro studies underwent assessment tool developed office health assessment translation systematic review detected 60 experimental studies 16 vitro 7 ex vivo 31 vivo 6 vitro vivo investigating role ar one clinical study found data six vitro nineteen vivo studies included metaanalyses preclinical models ar administration resulted improved neurological cognitive locomotor histological outcomes without change physiological parameters ie absence adverse events systematic review metaanalysis based experimental studies supports neuroprotective effect ar thus providing rationale potential translation ar treatment humans despite adherence established guidelines methodologies limitations data availability prevented analyses investigate potential sources heterogeneity due study design study funded part italian ministry healthcurrent researchirccs ministero della salute italiano ricerca finalizzata project rf 201912371416