Robert Adams|Sarah Appleton|Tiffany K. Gill|Anne Taylor|David H. Wilson|Catherine Hill
Cause for concern in the use of non-steroidal anti-inflammatory medications in the community -a population-based study
Queen Elizabeth Hospital|University of Adelaide|Queen Elizabeth Hospital|University of Adelaide|University of Adelaide|University of Adelaide|Queen Elizabeth Hospital|University of Adelaide|Queen Elizabeth Hospital
nonsteroidal antiinflammatory nsaid medications common cause reported adverse drug sideeffects study describes prevalence nonsteroidal antiinflammatory nsaid use lowdose aspirin presence coexisting relative contraindications nsaid use chronic conditions representative population sample data analysed 3206 adults attending first followup north west adelaide health study nwahs 2004 2006 longitudinal representative population study medications brought study clinic visits participants clinical assessment included measured blood pressure kidney function serum cholesterol blood glucose questionnaires assessed demographics lifestyle risk factors physiciandiagnosed chronic conditions data weighted census measures region age group gender probability selection household provide population representative estimates pearsons chisquare tests determined significant differences proportions multiple logistic regression used examine associations sociodemographic characteristics use nsaids 3175 participants 357 112 16 aged 55 years reported using either nonspecific nsaids cox2 inhibitors lowdose aspirin among people using nsaids 608 hypertension 308 stage 3 higher chronic kidney disease 172 history cardiovascular disease cvd 207 15 10year cvd risk prevalence nsaid use among people hypertension 16 kidney disease 159 history cvd 200 among people taking diuretics 241 also taking nsaids taking medications gastroesophageal reflux 247 nsaids prescriptiononly cox2 inhibitors nsaids used people 75 years 3554 year olds 37 95 ci 20 67 also commonly used people hypertension cardiac kidney disease high prevalence current nsaid use among groups atrisk significant drugrelated adverse events major chronic conditions relative contraindications nsaid use assessment absolute risks regarding cardiovascular kidney disease need take account use medications nsaids potential make substantial impact chronic disease burden via improved use nsaids considerable