Sadia Haider|Adnan ?ustovi?
Breaking Down Silos in Asthma Research: The Case for an Integrated Approach
Imperial College London|GlaxoSmithKline (Brazil)|Sanofi (France)|Regeneron (United States)|Boehringer Ingelheim (Philippines)|Bayer (United States)|Imperial College London|GlaxoSmithKline (Brazil)|Sanofi (France)|Regeneron (United States)|Boehringer Ingelheim (Philippines)|Bayer (United States)
asthma complex condition heterogeneous patterns symptoms underpinned different underlying pathophysiological mechanisms treatment responses analyses data birth cohorts patient studies subjective hypothesistesting approach datadriven hypothesisgenerating approach improved current understanding asthmas heterogeneity despite rapid proliferation new sources data increasingly sophisticated methods data mining revealing structure relatively findings translated clinically actionable solutions targeted therapeutics improved patient care review focusses integrated approach may powerful catalyst improved patient outcomes compared artificial imposed dichotomy hypothesisgenerating versus investigatorled subjective approaches factors shaping development control asthma affect individuals dynamically response treatment environmental factors deeper insights garnered integration data human expertise experience authors describe integrative approaches may greater power provide holistic understanding pathophysiological mechanisms driving asthma heterogeneity discussing key methodological challenges limit clinical use findings asthma research highlighting recent examples integrative approaches building bridges ensure power emerging sources data coupled rigorous scientific scrutiny lead nuanced understanding asthma