Mohammad Sorowar Hossain, Md Hasanul Banna Siam, Mohammad Nayeem Hasan, Rifat Jahan, Mahbubul H Siddiqee
Knowledge, attitude, and practice towards blood donation among residential students and teachers of religious institutions in Bangladesh - A cross-sectional study
Heliyon
glucagon glucagonlike peptide1 glp1 derived precursor proglucagon dual agonists receptors currently explored treatment obesity metabolic dysfunctionassociated steatotic liver disease masld elevated levels endogenous glucagon hyperglucagonaemia linked hyperglycaemia individuals type 2 diabetes also observed individuals obesity masld glp1 levels reported largely unaffected even reduced similar conditions investigated potential determinants plasma proglucagon associations glucagon receptor signalling metabolic diseases based data uk biobank used exome sequencing data uk biobank 410000 white participants identify glucagon receptor variants grouped based known predicted signalling data plasma levels proglucagon estimated using olink technology available subset cohort 40000 determined associations glucagon receptor variants proglucagon bmi type 2 diabetes liver fat quantified liver mri performed survival analyses investigate elevated proglucagon predicts type 2 diabetes development obesity masld type 2 diabetes associated elevated plasma levels proglucagon independently baseline proglucagon levels associated risk type 2 diabetes development 14 year followup period hr 113 95 ci 109 117 n1562 p131012 association magnitude across strata bmi carriers glucagon receptor variants reduced camp signalling elevated levels proglucagon 0847 95 ci 004 166 n17 p004 carriers variants predicted frameshift mutation higher levels liver fat compared wildtype reference group 0504 95 ci 003 098 n11 p004 findings support suggestion glucagon receptor signalling involved masld plasma levels proglucagon linked risk type 2 diabetes development proglucagon levels influenced genetic variation glucagon receptor obesity type 2 diabetes masld determining molecular signalling pathways downstream glucagon receptor activation may guide development biased glp1glucagon coagonist improved metabolic benefits coding available httpsgithubcomnicwin98ukbiobankgcg