Kenichi Meguro|Mari Kasai|Kyoko Akanuma|Mitsue Meguro|Hiroshi Ishii|Satoshi Yamaguchi
Donepezil and life expectancy in Alzheimer’s disease: A retrospective analysis in the Tajiri Project
Tohoku University|Tohoku University|Tohoku University|Tohoku University|Tohoku University
cholinesterase inhibitors cheis donepezil effect delaying progression alzheimers disease ad effect life expectancy unclear analyzed influence donepezil life expectancy onset ad together effects antipsychotic drugs residency nursing homeall outpatients tajiri clinic 19992012 available medical records death certificates included retrospective analysis entry criteria dementia diagnosis based dsmiv criteria diagnosis ad using nincdsadrda criteria medical treatment 3 months follow less 1 year deathwe identified 390 subjects medical records death certificates 275 diagnosis dementia met entry criteria 100 patients diagnosed ad 52 taken donepezil 48 patients received drug due treatment prior introduction donepezil 1999 japan lifetime expectancies onset 79 years donepezil group 53 years nondonepezil group significant drug effect significant covariate effect nursing home residency covariates reach significant levelalthough report limitation retrospective analyses lack randomization found positive effect donepezil lifetime expectancy onset ad may due decreased mortality rate caused reduction concomitant diseases pneumonia similar life expectancies patients taking donepezil home taking donepezil nursing home indicated positive health economic effect drug