Jai Prakash Agarwal|Indranil Mallick|Ritu Bhutani|Sarbani Ghosh?Laskar|Tejpal Gupta|Ashwini Budrukkar|Vedang Murthy|Manju Sengar|Ketayun A. Dinshaw
Prognostic factors in oropharyngeal cancer – analysis of 627 cases receiving definitive radiotherapy
Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital|Tata Memorial Hospital
aim retrospective analysis analyze results conventional radical radiotherapy treatment oropharyngeal cancer identify pretreatment treatmentrelated prognostic factors outcomethe records 627 patients oropharyngeal cancer treated radical radiotherapy conventional techniques analyzedthe median age 56 years history tobacco abuse present 805 eighty six percent stage iii iv disease radical radiotherapy alone treatment modality 712 concomitant neoadjuvant chemotherapy used 288 3year local control lc locoregional control lrc diseasefree survival dfs overall survival os 49 406 389 361 respectively 3year dfs rates 803 stage 658 stage ii 461 stage iii 252 stage iv disease multivariate analysis performed prognostic factors prior history tobacco abuse independent prognostic factor dfs lrc karnofsky performance score kps 80 higher nodal stage lower total radiotherapy dose 66 gy receiving 60 gy overall treatment time 50 days independent prognostic factors inferior dfs lrc kps 80 higher stage higher nodal stage rt dose 66 gy longer overall treatment time 50 days independent prognostic factors poorer local controlseveral patient disease treatmentrelated variables independently affect survival outcomes radical radiotherapy oropharyngeal cancer oropharyngeal cancers without history tobacco abuse may biologically different amenable cure radiotherapy