Christian Staerk, Hannah Klinkhammer, Tobias Wistuba, Carlo Maj, Andreas Mayr
Generalizability of polygenic prediction models: how is the R2 defined on test data?
BMC medical genomics
failed spinal anaesthesia causes prolonging operation time insufficient analgesia surgery needs repeating spinal anaesthesia turn causes local anaesthesia toxicity high spinal total spinal conversion general anaesthesia however problem remains unexplored amhara regional state comprehensive specialized hospitals determine incidence factors associated failed spinal anaesthesia among patients undergoing surgery selected amhara national regional state comprehensive specialized hospitals northwest ethiopia 2023 multicenter prospective observational study conducted data collected using questionnaire checklist consecutive scheduled emergency elective patients included study data transformed epi data spss logistic regression analysis done crude adjusted odds ratio used assess strength association variables pvalue less 005 considered statistically significant total 532 patients included study response rate 98 incidence failed spinal anaesthesia 224 ci 19259 emergency surgery aor 701 ci 45127 dose bupivacaine 10 mg aor 302 ci 13102 work experience anaesthetist 2 years aor 31 ci 17572 bloody csf aor 85 ci 253185 hyperbaric local anaesthetic drug aor 33 95 ci 3282 local anaesthetist without adjuvants aor 525 ci 262142 associated failed spinal anaesthesia incidence failed spinal anaesthesia high amhara region comprehensive specialized hospitals suggest anaesthesia providers minimize failure using adjuvants appropriate dose local anaesthetic additionally simulation training given anaesthesia trainees improve skills produce competent professionals