Rebecca L Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A Gifford, Kimberly R Pechman, Mabel Seto, Vladislav A Petyuk, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohman
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Molecular neurodegeneration
extracorporeal membrane oxygenation increasingly utilized provide cardiopulmonary support critically ill children although lifesaving many instances extracorporeal membrane oxygenation support associated considerable morbidity mortality study evaluates effect extracorporeal membrane oxygenation complications extracorporeal membrane oxygenation hospital characteristics mortality neonates children supported extracorporeal membrane oxygenation retrospective analysis administrative data data 31 us states included 2012 healthcare cost utilization project kids inpatient database children treated extracorporeal membrane oxygenation none study subject identified using international classification diseases 9th edition clinical modification code 3965 classified six diagnostic categories 1 cardiac surgery 2 nonsurgical heart disease 3 congenital diaphragmatic hernia 4 neonatal respiratory failure 5 pediatric respiratory failure 6 sepsis demographics hospital characteristics outcome information used multivariate logistic regression analysis determine factors associated mortality identified 1465 children treated extracorporeal membrane oxygenation overall mortality 40 5911465 mortality independently associated diagnosis heart disease odds ratio 17 p 001 congenital diaphragmatic hernia odds ratio 51 p 0001 sepsis odds ratio 24 p 0003 compared neonatal respiratory failure time hospital admission extracorporeal membrane oxygenation 10 days odds ratio 45 p 0001 extracorporeal membrane oxygenation complications renal odds ratio 5 p 0001 neurologic odds ratio 14 p 003 injury addition hospitals bed size less 400 higher mortality odds ratio 14 p 002 patients extracorporeal membrane oxygenation complication probability mortality lower extracorporeal membrane oxygenation patients larger hospitals 38 95 ci 3739 versus 44 95 ci 4346 p value less 0001 extracorporeal membrane oxygenation mortality significantly associated patient diagnosis time extracorporeal membrane oxygenation initiation extracorporeal membrane oxygenation complications extracorporeal membrane oxygenation hospital bed size improved survival larger hospitals supports centralization extracorporeal membrane oxygenation services larger centers