Robert K. McNamara|Wilhelmina Kalt|Marcelle D. Shidler|Jane E. McDonald|Suzanne Summer|Amanda L. Stein|Amanda N. Stover|Robert Krikorian
Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment
University of Cincinnati Medical Center|Agriculture and Agri-Food Canada|University of Cincinnati Medical Center|Agriculture and Agri-Food Canada|Cincinnati Children's Hospital Medical Center|University of Cincinnati Medical Center|University of Cincinnati Medical Center|University of Cincinnati Medical Center
given evidence eicosapentaenoic acid epa docosahexaenoic acid dha anthocyaninrich blueberries provide neurocognitive benefit investigated longterm supplementation older adults cognitive complaints 24week randomized doubleblind placebocontrolled trial elderly men women received daily fish oil fo blueberry bb diet records confirmed participants reduced background consumption epa dha anthocyanins prescribed erythrocyte epa dha composition increased fo groups p 00001 total urinary anthocyanins differ groups supplementation glycoside native food forms increased bbsupplemented groups fo p 003 bb p 005 groups reported fewer cognitive symptoms bb group showed improved memory discrimination p 004 indicating supplementation improved cognition cognitive benefit bb group associated presence urinary anthocyanins reflecting recent bb intake anthocyanin metabolites however combined fo bb treatment associated cognitive enhancement expected