Abdallah Abbas, Aya M Fayoud, Mostafa Hossam El Din Moawad, Abdullah Ashraf Hamad, Heba Hamouda, Eman A Fouad
Safety and efficacy of trofinetide in Rett syndrome: a systematic review and meta-analysis of randomized controlled trials
BMC pediatrics
research individual differences performance tests cognitive ability focuses general cognitive ability g highest level threelevel cattellhorncarroll chc hierarchical model intelligence 50 variance g due inherited dna differences heritability increases across development much less known genetics middle level chc model includes 16 broad factors fluid reasoning processing speed quantitative knowledge provide metaanalytic review 747567 monozygoticdizygotic twin comparisons 77 publications middlelevel factors refer specific cognitive abilities sca even though factors independent g twin comparisons available 11 16 chc domains average heritability across sca 56 similar g however substantial differential heritability across sca sca show developmental increase heritability seen g also investigated sca independent g scag surprising finding scag remain substantially heritable 53 average even though 25 variance sca covaries g removed review highlights need research sca especially scag despite limitations sca research review frames expectations genomic research use polygenic scores predict sca scag genomewide association studies scag needed create polygenic scores predict sca profiles cognitive abilities disabilities independent g