Clinton B. Wright|Joanne R. Festa|Myunghee Cho Paik|Alexis Schmiedigen|Truman R. Brown|Mitsuhiro Yoshita|Charles DeCarli|Ralph L. Sacco|Yaakov Stern
White Matter Hyperintensities and Subclinical Infarction
Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University|Columbia University
examined white matter hyperintensity volume wmhv subclinical infarction history clinical stroke si relation performance tests sequencing cognitive flexibility sensorimotor abilitythe northern manhattan study includes strokefree communitybased sample hispanic black white participants subsample n656 undergone measurement wmhv si neuropsychological testing linear regression used examine wmhv si relation performance tests sequencing measured color trails 1 cognitive flexibility measured color trails 2 sensorimotor ability measured grooved pegboard using generalized estimating equations gee account correlation among cognitive tests covariatesconsidering performance tests sequencing cognitive flexibility sensorimotor ability simultaneously using gee wmhv subclinical infarction associated worse cognitive performance globally threshold effect wmhv upper quartile performing significantly worse tests cognitive flexibility sensorimotor ability frontal si performed worse test cognitive flexibility deep si worse test sequencingboth si wmhv associated globally worse cognitive performance participants wmh affecting 075 cranial volume significantly slower performance task cognitive flexibility sensorimotor ability lowest quartile effects si cognitive performance varied location