Geraldine Moreno-Black, Shawn Boles, Deb Johnson-Shelton, Cody Evers
Exploring Categorical Body Mass Index Trajectories in Elementary School Children
The Journal of school health
severe early childhood caries secc highly prevalent affecting childrens oral health secc development closely associated complex oral microbial microbiome microorganism interactions imbalance bacteriophages bacteria till little known oral phageome secc therefore study aimed investigate potential role oral phageome pathogenesis secc unstimulated saliva 2 ml collected 20 children without secc metagenomics analysis metagenomics sequencing bioinformatic analysis performed determine two groups phageome diversity taxonomic functional annotations statistical analysis visualization performed r spss statistics software 857 extracted viral sequences predicted phages phages classified myoviridae siphoviridae podoviridae alpha diversity decreased beta diversity increased secc phageome compared healthy group abundance podoviridae phages increased abundance inoviridae herelleviridae streptococcus phages decreased secc group functional annotation revealed increased annotation glycoside hydrolases nucleotide metabolism decreased glycosyl transferases carbohydratebinding modules biogenic metabolism secc phageome metagenomic analysis revealed reduced streptococcus phages significant changes functional annotations within secc phageome findings suggest potential weakening regulatory influence oral bacteria may indicate development innovative prevention treatment strategies secc implications deserve investigation hold promise advancing understanding management secc findings study indicate oral phageomes associated bacterial genomes metabolic processes affecting development secc reduced modulatory effect oral phageome counteracting seccs cariogenic activity suggests new avenue prevention treatment secc