Jose Jiron|Seema Sethi|Rouba Ali?Fehmi|Silvia Franceschi|Linda Struijk|Leen Jan Van Doorn|Wim Quint|Ikuko Kato
Racial disparities in Human Papillomavirus (HPV) associated head and neck cancer
Wayne State University|Wayne State University|Wayne State University|International Agency For Research On Cancer|DDL Diagnostic Laboratory|DDL Diagnostic Laboratory|DDL Diagnostic Laboratory|Wayne State University
poorer survival head neck squamous cell carcinoma hnscc african americans aa may due disparity prevalence human papillomavirus hpv earlier studies often failed control etiological factors aimed elucidate whether racial disparities hpv prevalence overall survival due confounding smoking alcohol use 385 patients scc mouth pharynx nose larynx surgical resection wayne state university affiliated hospitals identified populationbased cancer registry formalin fixed paraffin embedded tissue blocks used determine presence hpv dna genotype using sensitive broadspectrum pcr technique patients demographics tumor characteristics vital status obtained record linkage registry data smoking alcohol information abstracted medical record coxs proportional hazard model unconditional logistic regression models employed analyze overall survival tumor hpvpositivity respectively hpv positivity oropharyngeal cancer substantially lower aa racial groups odds ratio 014 95 confidence interval ci 005037 adjustment smoking alcohol change association however significantly increased hazard ratio death aa oropharyngeal cancer patients univariable hazard ratio hr 255 95 ci 142459 decreased almost unity hr 149 95 ci 075293 adjustment hpv smoking lower hpv prevalence aa largely accounts poorer survival oropharyngeal cancer hnssc