Yuka Morita, Chihiro Yagi, Tadashi Wada, Toshiyuki Fujisaki, Hajime Ohtaki, Meiko Kitazawa, Tatsuya Yamagishi, Shinsuke Ohshima, Shuji Izumi, Yutaro Oi, Shinsuke Ito, Arata Horii
The impact of hearing aids on cognitive function and quality of life in patients with hearing impairment: A cross-sectional study
Auris, nasus, larynx
kidney plays critical role excreting ammonia metabolic acidosis liver failure mechanisms behind process poorly explored present study combines results vivo experiments increased total ammoniagenesis systems biology modeling eight rats fed amino acidrich diet hd group eight normal chow diet al group developed method based elementary mode analysis study changes amino acid flux occurring across kidney increased ammoniagenesis elementary modes represent minimal feasible metabolic paths steady state model used predict amino acid fluxes healthy prehyperammonemic conditions compared experimental fluxes rats first found total renal ammoniagenesis increased 264 68 612 87 nmol 100 g body weight1 min1 hd group p 0021 concomitated upregulation nkcc2 ammonia transporters kidney kidney metabolic model best predictions obtained ammonia transport objective objectives resulting fair correlation measured fluxes correlation coefficient 05 growth protein uptake urea excretion lysine phenylalanine transport predictions improved specific gene expression data considered hd conditions suggesting role mitochondrial glycine pathway studies needed determine regulation mitochondrial glycine pathway ammonia transporters modulated use kidney therapeutic target hyperammonemia