Katyane Larissa Alves, Ruffo Freitas, Régis Resende Paulinelli, Marcus Nascimento Borges
Comparison of medical image interpretation time between conventional and automated methods of breast ultrasound
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
exposure single chemical exist reality mixtures ecological norm often characterized numerous intrinsic driving factors unknown combined effects interactions heterogeneous chemicals chemical nonchemical stressors could alter toxicity traits relative single exposure hence revealing hidden environmental effects affecting multiple stressor interactions essential expand knowledge uncertainty sources chemical riskbased decision contexts global sensitivity analysis gsa techniques involving morris method sampling elementary effects ee sensitivity analysis applied investigate driving factors underlying combined effects scenedesmus obliquus identify mode interaction mixtures environmentallyrelevant concentrations one hundred mixedexposure formulas generated 9 variables 8 chemicals temperature via morris method representing environmental perspective field subsequently ee sensitivity analysis combined quantitative highthroughput screening qhts adopted identify critical mixture primary drivers combined exposure exerted significantly increased effects obliquus compared effects individual exposure critical drivers identified validated control variate method mode combined action mixture toxicity match additivity relationship strong interaction existed among chemicals collectively data provides evidence combination specific pesticides emerging brominated flame retardants produce comparable even stronger bionegative effects pure chemicals due complicated interactions method used offers direct comparison multifarious factors unified standard scale bridges actual interaction scenarios field toxicity simulations laboratory fill gap ecotoxicology