Christopher P. Wild
The exposome: from concept to utility
International Agency For Research On Cancer
broad sense nongenetic exposome therefore complements genome providing comprehensive description lifelong exposure history remaining focused element application epidemiology key ensuring exposome translated concept utility better delineating causes prevention human disease time original proposal recognized whereas exquisite tools developed sequence human genome interrogate individual susceptibility genomewide association studies gwas relative paucity comparable tools indeed investment relation exposure assessment given cancer chronic diseases develop predominantly combination environmental exposures played particular genetic background inability measure one part geneenvironment combination anything approaching precision stymie progress becomes particularly acute epidemiology aims tease relatively modest effect sizes associated specific environmental exposures commentary seeks define exposome describe realisation may achieved epidemiological studies commentary focuses cancer many concepts applicable chronic diseases