Habtamu Teshome, Yilfashewa Seyoum, Derebssa Dufera, Samuel Assefa
Academics' Beliefs Regarding the Importance of Curriculum Internationalization in the Ethiopian Research Universities
Heliyon
background tuberculosis tb intestinal helminth infections often coexist posing significant health challenge tb caused mycobacterium tuberculosis helminths elicit distinct immune responses th1 tb th2 helminths coinfection introduces complex immunological challenge potentially compromising tb control study addresses research gap comparing cytokine profiles monocyte responses tb patients helminthinfected individuals insights gained may enhance diagnosis treatment disease control strategies tb helminths prevail methods crosssectional observational study conducted indira gandhi institute medical sciences patna bihar aimed compare cytokine profiles monocyte responses tb patients coinfected tb helminths study included 150 newly diagnosed active tb individuals aged 18 65 years tb diagnosis confirmed clinical assessment sputum microscopy genexpert cepheid sunnyvale ca usa testing stool examination employed various methods including katokatz technique formalinether concentration blood samples collected hematological analysis cytokine profiling monocyte isolation statistical analysis using spss version 200 ibm corp armonk ny usa included descriptive statistics ttest analyses results study 150 participants half 500 showed positive helminth status sociodemographic analysis revealed significant differences age gender education occupation marital status smoking alcohol bmi diabetes hypertension tb patients n75 tbhelminth patients n75 ensuring baseline matching prevalence specific helminth infections tbhelminth patients included ascaris lumbricoides 240 trichuris trichiura 187 others hematological parameters showed significant differences tbhelminth patients exhibiting higher rbc count hemoglobin hematocrit neutrophil count monocyte count also eosinophil count raised tbhelminth patients 036 x 103l compared tb patients 025 x 103l cytokine profiles monocyte responses varied significantly groups tb patients higher il4 il6 ifn tnf il1 levels tbhelminth patients elevated il10 monocyte response time differ significantly conclusion observed differences hematological parameters cytokine profiles emphasize need tailored approaches diagnosis treatment coinfected individuals findings suggest management tb patients consider potential influence helminth coinfections