Marjo Mensonen, Sari Pramila-Savukoski, Kristina Mikkonen, Tiina Törmänen, Jonna Juntunen, Heli-Maria Kuivila
The experiences of social and health care and health sciences educators of implementing hybrid teaching in higher education: A qualitative study
Nurse education today
rapidly accumulating knowledge biological entities networks growing need general framework understand information system level order understand life system formal description system dynamics semantic validation necessary within context biological pathways several formats proposed eg sbml cellml biopax unfortunately formats lack formal definitions term fail capture system dynamics behavior thus developed new system dynamics centered ontology called cell system ontology cso exchange format ontology implemented web ontology language owl enables semantic validation automatic reasoning check consistency biological pathway models features cso follows 1 manipulation different levels granularity abstraction pathways eg metabolic pathways regulatory pathways signal transduction pathways cellcell interactions 2 capture quantitative qualitative aspects biological function using hybrid functional petri net extension hfpne 3 encoding biological pathway data related visualization simulation well modeling new ontology also predefines mature core vocabulary necessary creating models system dynamics addition core terms least one standard icon easy modeling accelerating exchangeability among applications order demonstrate potential csobased pathway modeling visualization simulation present hfpne model asel aser regulatory networks caenorhabditis elegans