Erin E Centeio, Nate McCaughtry, E Whitney G Moore, Noel Kulik, Alex Garn, Jeffrey Martin, Bo Shen, Cheryl L Somers, Mariane Fahlman
Building healthy communities: A comprehensive school health program to prevent obesity in elementary schools
Preventive medicine
aimed develop internally validate realworld prognostic model level 3 hypoglycaemia risk compatible outpatient care united states inphorm 12month usbased panel survey adults 1890 years old type 1 diabetes mellitus insulin andor secretagoguetreated type 2 diabetes mellitus recruited nationwide probabilitybased internet panel among participants completing 1 followup questionnaires modelled 1year level 3 hypoglycaemia risk using andersen gills cox survival penalized regression multiple imputation candidate variables selected clinical relevance ease capture pointofcare total 986 participants type 1 diabetes mellitus 17 men 496 mean age 51 sd 143 years analysed across followup 0351 95 ci 322381 reported 1 level 3 events rate 50 95 ci 4160 events per personyear final model showed strong discriminative validity parsimony optimism corrected cstatistic 077 numerous variables selected age sex body mass index marital status level education insurance coverage race ethnicity food insecurity diabetes type glycated haemoglobin value glycated haemoglobin variability number type dose various medications number sh events requiring hospital care past year followup type number comorbidities complications number diabetesrelated health care visits past year use continuousflash glucose monitoring general health status inphorm first usbased primary prognostic study level 3 hypoglycaemia future model implementation could potentiate risktailored strategies reduce realworld event occurrence overall diabetes burden