Shaefali Shandilya, Justen M Aprile
Improvements in Interdisciplinary Communication Following the Implementation of a Standardized Handoff Curriculum: SAFETIPS (Statistics, Assessment, Focused Plan, Pertinent Exam findings, to Dos, If/Thens, Pointers/Pitfalls, and Severity of Illness)
Cureus
despite considerable progress genome proteomebased highthroughput screening methods rational drug design increase approved drugs past decade match increase drug development costs network description analysis give systemslevel understanding drug action disease complexity also help improve efficiency drug design give comprehensive assessment analytical tools network topology dynamics stateoftheart use chemical similarity protein structure proteinprotein interaction signaling genetic interaction metabolic networks discovery drug targets summarized propose network targeting follows two basic strategies central hit strategy selectively targets central nodesedges flexible networks infectious agents cancer cells kill network influence strategy works diseases efficient reconfiguration rigid networks needs achieved targeting neighbors central nodesedges shown network techniques help identification singletarget edgetic multitarget allonetwork drug target candidates review recent boom network methods helping hit identification lead selection optimizing drug efficacy well minimizing sideeffects drug toxicity successful networkbased drug development strategies shown examples infections cancer metabolic diseases neurodegenerative diseases aging summarizing 1200 references suggest optimized protocol networkaided drug development provide list systemslevel hallmarks drug quality finally highlight networkrelated drug development trends helping achieve hallmarks cohesive global approach