KeunBaDa Son, Kyu-Bok Lee
Effect of computer literacy on the working time of the dental CAD software program
Journal of prosthodontic research
early identification patients highrisk endstage renal disease esrd essential providing optimal care implementing targeted prevention strategies kidney failure risk equation kfre offers accurate prediction esrd risk compared static egfrbased thresholds provide insights patientspecific biological mechanisms drive esrd study focused evaluating effectiveness kfre ukbased advanced chronic kidney disease ckd cohort investigating whether integration proteomic signature could enhance 5year esrd prediction using salford kidney study biobank ukbased prospective cohort 3000 nondialysis ckd patients 433 patients met inclusion criteria minimum four egfr measurements twoyear period linear egfr trajectory plasma samples obtained analysed novel proteomic signals using swathmassspectrometry 4variable ukcalibrated kfre calculated patient based baseline clinical characteristics boruta machine learning algorithm used selection proteins contributing differentiation patient groups logistic regression employed estimation esrd prediction 1 proteomic features 2 kfre 3 proteomic features alongside kfre swath maps 943 quantified proteins generated investigated tandem available clinical data identify potential progression biomarkers identified set proteins spta1 myl6 c6 used alongside 4variable ukkfre improved prediction 5year risk esrd auc 075 vs auc 070 functional enrichment analysis revealed rho gtpases regulation actin cytoskeleton pathways statistically significant inferring role kidney function pathogenesis renal disease proteins spta1 myl6 c6 used alongside 4variable ukkfre achieve improved performance predicting 5year risk esrd specific pathways implicated pathogenesis podocyte dysfunction also identified could serve potential therapeutic targets findings study carry implications comprehending involvement rho family gtpases pathophysiology kidney disease advancing understanding proteomic factors influencing susceptibility renal damage