Yasir J. Sepah|Masood Umer|Tashfeen Ahmad|Faria Nasim|Muhammad Umer Chaudhry|Muhammad Umar
Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement
Aga Khan University|Aga Khan University Hospital|Aga Khan University Hospital|Aga Khan University|Aga Khan University|Aga Khan University Hospital
allogenic blood transfusion elective orthopaedic surgery best avoided owing associated risks total knee replacement often requires blood transfusion bilateral surgery performed many strategies currently employed reduce amount perioperative allogenic transfusions antifibrinolytic compounds aminocaproic acid tranexamic acid used systemically perioperative settings promising results study aimed evaluate effectiveness tranexamic acid reducing allogenic blood transfusion total knee replacement surgerythis retrospective cohort study conducted patients undergoing total knee replacement time period november 2005 november 2008 study population 99 patients 70 underwent unilateral 29 bilateral knee replacement fortyseven patients 62 495 knees groupi received tranexamic acid surgeon preference remaining fiftytwo patients 66 515 knees groupii received tranexamic acid either pre postoperativelythe mean drop postoperative haemoglobin concentration groupii unilateral bilateral cases 179 gmdl 221 gmdl mean postoperative drainage 1828 ml unilateral 2695 ml bilateral comparison mean drop postop haemoglobin groupi 149 gmdl unilateral 194 gmdl bilateral mean drainage 826 ml unilateral 1288 ml bilateral pvalue 0001tranexamic acid effective reducing postoperative drainage requirement blood transfusion knee replacement