Virginia Elderkin?Thompson|Michael R. Irwin|Gerhard Hellemann|Anand Kumar
Interleukin-6 and Memory Functions of Encoding and Recall in Healthy and Depressed Elderly Adults
Biostats (United States)|University of Illinois at Chicago
activation proinflammatory cytokines associated depressed mood feelings fatigue changes cognitive function study examined relationships cognitive performance circulating cellular markers inflammation interleukin6 il6 creactive protein crp moderately depressed comparison healthy older adults conducted crosssectional analysis 87 volunteers 45 nondepressed 42 depressed participants completed structured clinical diagnostic interview evaluated geriatric psychiatrist dementia depression stroke risk neurologic disorders volunteers also completed electrocardiogram standard battery laboratory tests neuropsychological examination assessed memory functions encoding recall executive function attentionprocessing midmorning il6 crp levels assessed data analysis showed encoding recall inversely associated il6 across diagnostic groups controlling chronological age minimental state examination body mass index literacy level depression severity sex crp associated cognition depression status associated recall independent il6 levels conclusion il6 serum levels among elderly individuals significant correlate memory performance women particular appear sensitive il6 fluctuations across diagnostic groups