Genevieve Perrins, Tabassum Ferdous, Dawn Hay, Bobby Harreveld, Kerry Reid-Searl
Conducting Health Literacy Research With Hard-to-Reach Regional Culturally and Linguistically Diverse Populations: Evaluation Study of Recruitment and Retention Methods Before and During COVID-19
JMIR formative research
abstract general cognitive function prominent relatively stable human trait associated many important life outcomes combine cognitive genetic data charge cogent consortia uk biobank total n 300486 age 16102 find 148 genomewide significant independent loci p lt 5 10 8 associated general cognitive function within novel genetic loci variants associated neurodegenerative neurodevelopmental disorders physical psychiatric illnesses brain structure genebased analyses find 709 genes associated general cognitive function expression levels across cortex associated general cognitive function using polygenic scores 43 variance general cognitive function predicted independent samples detect significant genetic overlap general cognitive function reaction time many health variables including eyesight hypertension longevity conclusion identify novel genetic loci pathways contributing heritability general cognitive function