Ayeesha Kamran Kamal|Wardah Khalid|Abdul Muqeet|Anum Jamil|Kashfa Farhat|Sehar Rahim Ali Gillani|Maryam Zulfiqar|Mehreen Saif|Aliya Amin Muhammad|Fabiha Zaidi|Mohammad Mustafa|Ambreen Gowani|Shahrukh Sharif|Syedah Saira Bokhari|Javed Tai|Nasir Rahman|Fateh Ali Tipoo Sultan|Saleem Sayani|Salim S. Virani
Making prescriptions “talk” to stroke and heart attack survivors to improve adherence: Results of a randomized clinical trial (The Talking Rx Study)
Aga Khan University|Aga Khan University|Aga Khan Development Network|Aga Khan University|Aga Khan University Hospital|Aga Khan University Hospital|Aga Khan University Hospital|Aga Khan University Hospital|Aga Khan Development Network|Aga Khan Development Network|Aga Khan University Hospital|Aga Khan University|Aga Khan Development Network|Aga Khan University|Aga Khan University|Aga Khan University|Aga Khan University|Aga Khan Development Network|Michael E. DeBakey VA Medical Center|Baylor College of Medicine
developed tested effectiveness tailored health information technology driven intervention talking prescriptions talking rx improve medication adherence resource challenged environmentwe conducted parallel randomized controlled assessorblinded trial aga khan university aku karachi pakistan adults diagnosis cerebrovascular accident cva coronary artery disease cad diagnosed least one month enrollment antiplatelets statins access mobile phone enrolled intervention group received daily interactive voice response ivr call services regarding specific statin antiplatelet b daily tailored medication reminders statin antiplatelet c weekly lifestyle modification messages period 3 months assessed medication adherence statin antiplatelets validated version 8item morisky medication adherence scale 8 mmas8 3 months blinded assessment officer analysis conducted intentiontotreat principle ittbetween april 2015 december 2015 197 participants 99 intervention 98 usual care group enrolled talking rx study dropout rate 96 baseline group characteristics similar baseline mean mmas8 668 sd 128 intervention group 677 sd 136 usual care group end followup mean mmas8 increased 741078 intervention group compared 738 099 usual care group mean difference 003 sd 013 95 ci 023 029 statistically significant pvalue 040 cva patients showed relatively greater magnitude adherence via mmas8 end follow mean mmas8 increased 729 sd 082 intervention group compared 707sd 124 usual care group mean difference 022 sd 022 95 ci 020 065 pvalue 015 around 84 intervention arm used service calling least 3 times listening prescriptions average 8 minutes user excluded due technologic reasonsthe use phone based medication adherence program feasible lmic settings high volume clinics low patient literacy early study limited follow program achieve statistically significant differences adherence behavior selfreported mmas8 scaleclinical trialsgov nct02354040