Pier Mario Perrone, Simone Villa, Giuseppina Maria Raciti, Laura Clementoni, Valentina Vegro, Francesco Scovenna, Augusto Altavilla, Adriana Monica Tomoiaga, Valentina Beltrami, Ilaria Bruno, Marcello Vaccargiu, Elisa Astorri, Navpreet Tiwana, Matteo Letzgus, Peter Johannes Schulz, Fabrizio Ernesto Pregliasco, Silvana Castaldi
Influenza and Covid-19 Vaccination in 2023: a descriptive analysis in two Italian Research and Teaching Hospitals. Is the On-Site strategy effective?
Annali di igiene : medicina preventiva e di comunita
novel coronaviruses constitute significant health threat prompting adoption vaccination primary preventive measure however current evaluations immune response vaccine efficacy deemed inadequate study sought explore evolving dynamics immune response various vaccination time points breakthrough infections aimed elucidate synergistic effects epidemiological factors humoral immunity cellular immunity additionally regression curves used determine correlation protective efficacy vaccine stimulated immune response employing lasso highdimensional data analysis study utilised four machine learning algorithmslogistical regression random forest lgbm classifier adaboost classifierto comprehensively assess immune response following booster vaccination neutralising antibody levels exhibited rapid surge postbooster escalating 10238 auml one week peaking 29802 auml two weeks influential factors sex age disease history smoking status significantly impacted postbooster antibody levels study constructed regression curves neutralising antibodies nonswitched memory b cells cd4t cells cd8t cells using lasso combined random forest algorithm establishment artificial intelligence evaluation system emerges pivotal predicting breakthrough infection prognosis covid19 booster vaccination research underscores intricate interplay various components immunity external factors elucidating key insights enhance vaccine effectiveness 3d modelling discerned distinctive interactions humoral cellular immunity within prognostic groups class 02 underscores critical role synergistic effect humoral immunity cellular immunity epidemiological factors determining protective efficacy covid19 vaccines postbooster administration