Samah Mahmoud Sofar, Dhuha Youssef Wazqar, Narges Mohammed Syam
Effect of a Nurse-Led Rehabilitation Program: A Quasi-Experimental Study Examining Functional Outcomes in Patients With Hand Burns
Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
numerous studies shown older women endometrial cancer higher risk recurrence cancerrelated death however remains unclear whether older age causal prognostic factor whether risk factors become increasingly common age aimed address question unique multimethod study design using stateoftheart statistical causal inference techniques datasets three large randomised trials multimethod analysis data 1801 women participating randomised portec1 portec2 portec3 trials used statistical analyses causal inference cohort included 714 patients intermediaterisk endometrial cancer 427 patients highintermediate risk endometrial cancer 660 patients highrisk endometrial cancer associations age clinicopathological molecular features analysed using nonparametric tests multivariable competing risk analyses performed determine independent prognostic value age analyse age causal prognostic variable deep learning causal inference model called autoci used median followup estimated using reversed kaplanmeier method 123 years 95 ci 119126 portec1 105 years 102107 portec2 61 years 5963 portec3 overall recurrence endometrial cancerspecific death significantly increased age moreover older women higher frequency deep myometrial invasion serous tumour histology p53abnormal tumours age independent risk factor overall recurrence hazard ratio hr 102 per year 95 ci 101104 p00012 endometrial cancerspecific death hr 103 per year 101105 p00012 identified significant causal variable study showed advanced age associated aggressive tumour features women endometrial cancer independently causally related worse oncological outcomes therefore findings suggest older women endometrial cancer excluded diagnostic assessments molecular testing adjuvant therapy based age alone none