Saleh Salimi, Selman Özel
Insights for enhancing resilience in prolonged crises: impact of COVID-19 pandemic on nurses' quality of life
BMJ leader
limited data exist longitudinal kidney outcomes nonsurgical obesity treatments investigated effects intensive lifestyle intervention kidney function 10 years post hoc analysis action health diabetes look ahead randomized controlled trial studied 4901 individuals type 2 diabetes body mass index 25 kgm2 enrolled look ahead 20012015 original look ahead trial excluded individuals 4 urine dipstick protein serum creatinine level 14 mgdl women 15 mgdl men dialysis dependence intensive lifestyle intervention versus diabetes support education ie usual care primary outcome estimated glomerular filtration rate egfr mlmin173 m2 slope secondary outcomes mean egfr slope mean urine albumin creatinine ratio uacr mgmg linear mixedeffects models random slopes intercepts evaluate association randomization arms withinindividual repeated measures egfr uacr tested effect modification baseline egfr baseline mean egfr 89 83 normal uacr 10 years difference egfr slope 0064 per year 95 ci 0036 016 p 021 arms slope mean uacr differ arms baseline egfr categorized egfr 80 80100 100 modify interventions effect egfr slope mean loss muscle may confound creatininebased egfr patients type 2 diabetes preserved kidney function intensive lifestyle intervention change egfr slope 10 years among participants baseline egfr 80 lifestyle intervention slightly higher longitudinal mean egfr usual care studies evaluating effects intensive lifestyle intervention people kidney disease needed