Sadia Afreen, Alexander Krohannon, Saptarshi Purkayastha, Sarath Chandra Janga
Datawiz-IN: Summer Research Experience for Health Data Science Training
Research square
molecular cellular biology methodology traditionally based reasoning called mechanistic explanation practice means identifying selecting correlations biological processes result manipulation biological system theory successful application approach requires precise knowledge parameters studied system however practice due systems complexity requirement rarely ever accomplished typically limited quantitative semiquantitative measurements selected parameters eg concentrations metabolites qualitative semiquantitative description expressionposttranslational modifications changes within selected proteins quantitative proteomics approach gives possibility quantitative characterization entire proteome biological system context titer proteins well posttranslational modifications enables accurate testing novel hypotheses also provides tools used verify fundamental dogmas modern biology short review discuss consequences using quantitative proteomics verify several key concepts skeletal muscle physiology