Riyaan Mahamud Gabeyre, Misbah Hussein, Siedra Salih, Salia Amir, Parisa Gazerani
Social Prescribing Competence among Community Pharmacists and Pharmacy Students in Norway
Pharmacy (Basel, Switzerland)
despite widespread use polymers precipitation inhibitors supersaturating drug formulations current understanding mechanisms action still incomplete specifically role hydrophobic drug interactions polymers considering possible supramolecular conformations aqueous dispersion interesting topic accordingly study investigated tendency polymers create hydrophobic domains lipophilic compounds may nest support drug solubilisation supersaturation fluorescence spectroscopy environmentsensitive probe pyrene compared atomistic molecular dynamics simulations model drug fenofibrate feno subsequently kinetic drug supersaturation thermodynamic solubility experiments conducted result different polymers showed hydrophobic domain formation varying degree molecular simulations supported interpretation fluorescence spectroscopy data molecular insights gained conformational structure polymers interacted feno solution phase apart nucleation crystal growth effects determined drug concentrations solution notable even lowest polymer concentration 001 wv polymerspecific solubilisation effects feno observed resulting reduction apparent drug supersaturation provided relevant knowledge mechanistic practical perspective