Richard Odame Phillips|Fred Stephen Sarfo|Laure Guenin?Macé|Jérémie Decalf|Mark Wansbrough?Jones|Albert Tran|Caroline Demangel
Immunosuppressive Signature of Cutaneous<i>Mycobacterium ulcerans</i>Infection in the Peripheral Blood of Patients with Buruli Ulcer Disease
Komfo Anokye Teaching Hospital|Kwame Nkrumah University of Science and Technology|Komfo Anokye Teaching Hospital|Institut Pasteur|Inserm|St George's, University of London|Institut Pasteur|Inserm
buruli ulcer disease bud emerging human disease caused infection mycobacterium ulcerans leads development necrotic skin lesions pathogenesis ulcer closely associated production mycolactone diffusible cytotoxin immunomodulatory properties identify immunological correlates bud performed broad screen inflammatory mediators serum samples stimulated wholeblood supernatants patients found patients active ulcers displayed distinctive profile immune suppression marked downmodulation selected chemokines impaired capacity produce th1 th2 th17 cytokines stimulation mitogenic agents immunological defects induced early disease resolved antibud therapy establishing association presence ulcerans interestingly defects cytokine chemokine response could mimicked vitro incubation cd4 peripheral blood lymphocytes mycolactone findings support hypothesis mycolactone contributes bacterial persistence human hosts limiting generation adaptive cellular responses moreover identified immunological markers bud may helpful confirmatory diagnosis disease especially monitoring response antibiotic treatment