Deb K. Pal|Colin D. Ferrie|Laura Addis|Tomoyuki Akiyama|Giuseppe Capovilla|Roberto Caraballo|Anne de Saint?Martin|Natalio Fejerman|Renzo Guerrini|Khalid Hamandi|Ingo Helbig|Andreas A. Ioannides|Katsuhiro Kobayashi|Dennis Lal|Gaëtan Lesca|Hiltrud Muhle|Bernd A. Neubauer|Tiziana Pisano|Gabrielle Rudolf|Caroline Seegmüller|Takashi Shibata|Anna Smith|Pasquale Striano|Lisa J. Strug|Pierre Szepetowski|Thalia Valeta|Harumi Yoshinaga|Michalis Koutroumanidis
Idiopathic focal epilepsies: the “lost tribe”
Neuroscience Institute|King's College London|Evelina London Children's Healthcare|King's College Hospital|Leeds General Infirmary|Neuroscience Institute|King's College London|Okayama University|Azienda Ospedaliera Carlo Poma|Garrahan Hospital|Hôpitaux Universitaires de Strasbourg|Garrahan Hospital|Neuroscience Institute|King's College London|University Hospital of Wales|Cardiff University|University Hospital Schleswig-Holstein|University of Lübeck|Okayama University|Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases|University of Cologne|Inserm|French National Centre for Scientific Research|Claude Bernard University Lyon 1|Lyon Neuroscience Research Center|University Hospital Schleswig-Holstein|University of Lübeck|Universitätsklinikum Gießen und Marburg|Meyer Children's Hospital|University of Florence|Inserm|University of Strasbourg|Hôpitaux Universitaires de Strasbourg|King's College London|Neuroscience Institute|King's College London|Neuroscience Institute|University of Genoa|Institute for Clinical Evaluative Sciences|University of Toronto|Hospital for Sick Children|SickKids Foundation|Inserm|Institut de Neurobiologie de la Méditerranée|Aix-Marseille University|St Thomas' Hospital|Okayama University|Lambeth Hospital|St Thomas' Hospital
corollary questions regarding comorbidities role focal interictal spikes enduring impact cognitive functioningwhat explains paradox epilepsies characterised abundant interictal epileptiform abnormalities often associated clinical seizuresthis exciting area clinical experimental arenas eventually important implications clinical management whole child taking account seizures also adaptive functioning quality lifefor several decades accepted evidencefree approach using using antiepileptic drugs ifesthere huge international variation handful studies examining neurocognitive outcomesclearly situation ready overhaul practicefundamental understanding treatment knowledge aetiologyin recent years several significant discoveries ifes studies copy number variation exome sequencing linkage prompt reconsideration unknown cause classification strongly suggest genetic aetiologythe ife strongly agerelated regards age seizure onset remissiondoes time window solely relate similar agerelated gene expression epigenetic factors involved might also explain low observed twin concordancethe genetic epigenetic models different ifes comorbidities similarities neurodevelopmental disorders deserve investigation coming yearsin probably learn much normal brain functioningthis disorders perhaps human brain disease disorders functional brain systems even though functional networks may yet fully definedin june 2012 international group clinical basic science researchers met london auspices waterloo foundation discuss debate issues relation ifesthis waterloo foundation symposium idiopathic focal epilepsies phenotype genotype witnessed presentations explored clinical phenomenology phenotypes endophenotypes genetic approaches investigation disordersin parallel impact epilepsies children families reviewedthe papers supplement based upon presentationsthey represent updated stateoftheart thinking topics exploredthe symposium led formation international working groups umbrella lukes idiopathic focal epilepsy project investigate various aspects idiopathic focal epilepsies including semiology classification genetics cognition sleep highfrequency oscillations parental resources see wwwchildhoodepilepsyorgthe next sponsored international workshop june 2014 randomised controlled trials ifes overnight learning outcome measures