Pedro Gamito|Jorge Oliveira|Paulo Lopes|Rodrigo Brito|Diogo Morais|Diana Silva|Ana Silva|Sara Rebelo|Marta Bastos|Alberto Deus
Executive Functioning in Alcoholics Following an mHealth Cognitive Stimulation Program: Randomized Controlled Trial
Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona|Universidade Lusófona
consequences alcohol dependence severe may range physical disease neuropsychological deficits several cognitive domains alcohol abuse also related brain dysfunction specifically prefrontal cortex conventional neuropsychological interventions paperandpencil cognitive stimulation training positive effect timeconsuming costly motivating patientsour goal test cognitive effects novel approach neuropsychological intervention using mobile technology serious games patients alcohol dependencethe trial design consisted twoarm study assessing cognitive outcomes neuropsychological intervention mobile serious games mhealth versus control treatmentasusual neuropsychological intervention patients undergoing treatment alcohol dependence syndrome sixtyeight patients recruited alcoholrehab clinic randomly assigned mhealth n33 control condition n35 intervention experimental group consisted therapistassisted cognitive stimulation therapy 4 weeks 23 daysweek basisfourteen patients dropped study results neuropsychological assessments remaining 54 patients showed overall increase p05 general cognitive abilities mental flexibility psychomotor processing speed attentional ability experimental n26 control groups n28 however pronounced improvement p01 specifically frontal lobe functions baseline mean 1389 se 058 followup mean 1550 se 046 experimental group control groupthe overall increase general cognitive function experimental control groups supports beneficial role existing alcohol treatment protocols aimed minimizing withdrawal symptoms differential improvements observed frontal lobe functioning supports use mobile serious games neuropsychological stimulation overcome executive dysfunction patients alcohol dependence trial negative two neuropsychologicalcognitive tests positive oneclinicaltrialsgov nct01942954 httpwwwclinicaltrialsgovct2shownct01942954