Thida Ong|Michael S. Schechter|Jing Yang|Limin Peng|Julia Emerson|Ronald L. Gibson|Wayne J. Morgan|Margaret Rosenfeld
Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis
University of Washington|Children's Hospital of Richmond at VCU|Virginia Commonwealth University|Emory University|Emory University|University of Washington|University of Washington|University of Arizona|University of Washington
lower socioeconomic status ses environmental tobacco smoke ets exposure associated poorer disease outcomes cystic fibrosis cf children low ses disproportionately exposed ets analyzed large cohort young children cf distinguish impact ses ets clinical outcomesthe early pseudomonas infection control observational study enrolled pseudomonasnegative young children cf 13 years age enrollment survey assessed ses ets exposures forced expiratory volume 1 second fev1 crackles wheezes weightforage percentile assessed clinical encounter least 4 years repeated measures analyses estimated association ses ets exposures longitudinal clinical outcomes adjusting confoundersof 1797 participants 1375 eligible analysis maternal education high school less 281 268 household income 40 000 438 medicaid insurance maternal smoking birth present 248 prevalent household low ses separate models lower ses ets exposure significantly associated lower fev1 predicted presence crackles wheezes lower weight percentile combined models effect estimates ses changed minimally adjustment ets exposures whereas estimates ets exposures attenuated adjusting sesets exposure disproportionately high low ses families cohort children cf lower ses ets exposure independent adverse effects pulmonary nutritional outcomes estimated effect ses fev1 decreased minimally ets adjustment suggesting health disparity risks independent ets exposure