Anthony P. Monaco
Multivariate Linkage Analysis of Specific Language Impairment (SLI)
specific language impairment sli defined inability develop appropriate language skills without explanatory medical conditions low intelligence lack opportunity previously genome scan 98 families affected sli completed sli consortium resulting identification two quantitative trait loci qtl chromosomes 16q sli1 19q sli2 followed replication regions additional 86 families studies applied linkage methods one phenotypic trait time however investigations suggested simultaneous analysis several traits may offer power current study therefore applied multivariate variancecomponents approach sli consortium dataset using additional phenotypic data multivariate genome scan completed supported importance sli1 sli2 loci whilst highlighting possible novel qtl chromosome 10 investigation implied effect sli1 nonword repetition equally strong reading spelling phenotypes contrast sli2 appeared influences selection expressive receptive language phenotypes addition nonword repetition show linkage literacy phenotypes