Jaimie N Davis, Lauren C Martinez, Donna Spruijt-Metz, Nicole M Gatto
LA Sprouts: A 12-Week Gardening, Nutrition, and Cooking Randomized Control Trial Improves Determinants of Dietary Behaviors
Journal of nutrition education and behavior
present extension local effect model lem include timedose relationships predicting effects protracted splitdose ion irradiation arbitrary let kinetic extension spatial temporal induction processing dna double strand breaks dsb cellular nuclei simulated wide range ion radiation qualities doses dose rates key concept extension based joint spatial temporal coexistence initial dsb leading formation clustered dna damage scale defined eg size scale mbp chromatin loops considered increased cellular lethality compared isolated single dsb simulating time dependent induction repair dsb scoring isolated clustered dsb upon irradiation impact dose rate split dose cell survival probability computed first part work systematically analyze predicted impact protraction dependence factors like dose let ion species radiosensitivity characterized photon lqparameters establish links common concepts describe dose rate effects low let radiation also compare model predictions experimental data find agreement general trends observed experiments relevant concepts approach compared models suitable predicting time effects investigate apparent analogy spatial temporal concentration radiation delivery leading increased effectiveness discuss similarities differences general dependencies clustering effects impacting factors finally conclude findings give additional support general concept lem ie characterization high let radiation effects based distinction two classes dsb isolated dsb clustered dsb