Sohil H Patel, Jason N Itri
The Role of Intuitive Cognition in Radiologic Decision Making
Journal of the American College of Radiology : JACR
teaching resource provides lecture notes slides student assignment twopart lecture introduces stochastic modeling biological systems first lecture uses biological examples present concept celltocell variability makes connection variability singlecell measurements concepts statistical mechanics probability theory section makes point low copy number species usual differential equation formalism longer applicable needs replaced probabilistic approach based socalled master equation example simple model gene transcription discussed detail different contributions relevant master equation highlighted equation derived second lecture describes complex biologically interesting applications direct solution master equation becomes difficult gillespies algorithm used cases biological interest introduced practical alternative lecture delves crux gillespies algorithm entails drawing two random numbers time step establishes corresponding formalism details connection chemical rate constants gillespie rates culminates description explanation core matlab program transcriptional model considered first lecture core program written single cell expanded students homework assignment consider transcription translation