Diane Gilbert?Diamond|Jennifer A. Emond|Emily Baker|Susan Korrick|Margaret R. Karagas
Relation between <i>in Utero</i> Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire
Dartmouth College|Dartmouth College|Dartmouth–Hitchcock Medical Center|Brigham and Women's Hospital|Harvard University|Dartmouth College
background studies suggest arsenic exposure influences birth outcomes however findings mixedobjective assessed utero arsenic exposure relation birth outcomes whether maternal prepregnancy weight infant sex modified associationsmethods among 706 motherinfant pairs exposed low levels arsenic drinking water diet assessed utero arsenic exposure using maternal secondtrimester urinary arsenic maternal prepregnancy weight selfreport birth outcomes medical recordsresults median interquartile range total urinary arsenic tas inorganic arsenic ias monomethyl arsonic acid mma dimethylarsinic acid dma 34 gl 1760in adjusted linear models doubling tas associated 010cm decrease 95 ci 019 001 head circumferenceresults similar mma dmalntas lndma positively associated birth length infant males among males doubling tas associated 028cm increase 95 ci 009 046 birth length p interaction 004results similar dmaadditionally arsenic exposure inversely related ponderal index associations differed maternal weighteach lntas doubling tas associated 055kgm 3 lower 95 ci 082 028 p 0001 ponderal index infants overweightobese normalweight mothers p interaction 001finally significant inter action maternal weight status infant sex arsenic exposure birth weight p interaction 003in girls born overweightobese mothers doubling tas associated 629g decrease 95 ci 1116 142 birth weight though association null strataconclusions lowlevel arsenic exposure may affect fetal growth associations may modified maternal weight status infant sex