Yousef Mansouri, Ehsan Naderifar, Alireza Hajiyakhchali, Negin Moradi
The Dysphonia Severity Index as a Mediator for the Relationship Between the Vocal Fatigue Index and the Voice-Related Quality of Life Among Elementary Teachers with Voice Complaint
Journal of voice : official journal of the Voice Foundation
primary metastatic breast cancer pmbc accounts 510 annual breast cancers median survival 34 years varying among subtypes denmark incidence breast cancer increased 2010 followed stabilisation several factors influencing pmbc incidence survival including screening prevalence staging methods classification standards remain pivotal inadequately documented retrospective observational study involving pmbc patients diagnosed 2000 2020 encompassed danish oncology departments data danish breast cancer group database national patient register included diagnosis specifics demographics treatment followup 2000 2020 3272 patients diagnosed pmbc rise 355 patients 20002004 1323 patients 20152020 increase particularly observed patients aged 70 years older changes tumour subtypes observed notably rise human epidermal growth factor receptor 2 her2positive cases steady distribution estrogen receptor er status diagnostic practices changed two decades 6 evaluated petct positron emission tomographycomputed tomography ct computed tomography bone evaluation 20002004 65 20152020 overall survival os improved 23 months 20002004 33 months 20152020 patients erpositive her2positive disease multivariable model showed improved survival year diagnosis patients ernegativeher2negative disease fared worse first 2 years diagnosis study delineates changes treatment survival pmbc two decades stage migration screening introduction changes registration practice however prevent valid assessment possible causal relationship