Stephanie Supriadi, Djatnika Setiabudi, Anindita Noviandhari, Raden Tina Dewi Judistiani, Budi Setiabudiawan, Meita Dhamayanti
Correlation between Cord Blood Vitamin D Levels and Problem-Solving Neurodevelopment in Early Childhood: A Cohort Study in Rural Indonesia
Children (Basel, Switzerland)
lung cancer leading cause cancer death majority cases nonsmall cell lung cancer nsclc 1 common complication nsclc brain metastasis bm 2 3 prognosis remains poor despite new treatments real world data complements data gained clinical trials providing information patients excluded prospective research 4 however information patient notes may prove incomplete difficult extract developed algorithm identify patients clinical database brain metastasis electronic health record ehr retrospectively extracted data ehr patients managed large teaching hospital 2007 2018 using icd10 code c34 lung cancer algorithm used phrases associated bms search unstructured text radiology reports summary statistics univariant analysis performed overall survival 818 patients identified potentially bm 453 patients confirmed clinical review records median age patients 69 years 50 female 66 performance status 2 122 identifiable mutation 115 identified pdl1 positive first line setting 65 patients received symptomatic treatment 23 received systemic anticancer therapy sact 61 surgery 10 radiotherapy 65 external beam 35 stereotactic radiosurgery regarding treated sact 35 intracranial response treatment 3 complete response 32 partial response median survival 2 months 19 24 months 95 ci realworld prognosis nsclc patients bms poor using algorithm reported outcomes comprehensive cohort patients helps identify active treatment approach appropriate