Dzmitry Hramyka, Henrike Lisa Sczakiel, Max Xiaohang Zhao, Oliver Stolpe, Mikko Nieminen, Ronja Adam, Magdalena Danyel, Lara Einicke, René Hägerling, Alexej Knaus, Stefan Mundlos, Sarina Schwartzmann, Dominik Seelow, Nadja Ehmke, Martin Atta Mensah, Felix Boschann, Dieter Beule, Manuel Holtgrewe
REEV: review, evaluate and explain variants
Nucleic acids research
experiments show monolayer cells cultured elastic substratum subject cyclic stretch cells tend reorient either perpendicularly oblique angle respect main stretching direction due stochastic effects however distribution angles achieved cells broader experimentally histograms interval formula see text usually reported determine evolution stationary state probability density functions describing statistical distribution orientations cells using fokkerplanck equations derived microscopic rules describing reorientation process cell first attempt shall use stochastic differential equation related general elastic energy cell tries minimize show results time integration stationary state related forward fokkerplanck equation compare well experimental results obtained different researchers order model accurately microscopic process cell reorientation shed light mechanisms performed cells subject cyclic stretch consider discrete time random processes allow recover fokkerplanck equations classical tools kinetic theory particular shall introduce model reorientation function rotation angle result optimal control problem also latter case results match well experiments