Adam Whaley?Connell|Michael G. Shlipak|Lesley A. Inker|Manjula Kurella Tamura|Andrew S. Bomback|Georges Saab|Susanna Szpunar|Samy I. McFarlane|Suying Li|Shu?Cheng Chen|Keith C. Norris|George L. Bakris|Peter A. McCullough
Awareness of Kidney Disease and Relationship to End-stage Renal Disease and Mortality
Harry S. Truman Memorial Veterans' Hospital|University of Missouri|University of California, San Francisco|Tufts Medical Center|Palo Alto University|Stanford University|Columbia University|Washington University in St. Louis|Ascension|SUNY Downstate Medical Center|Medical Research Foundation|Medical Research Foundation|Charles R. Drew University of Medicine and Science|University of Chicago|Ascension
often patients chronic kidney disease reported unaware prospectively evaluated association awareness kidney disease endstage renal disease mortalitywe utilized 20002009 data national kidney foundations kidney early evaluation program mortality determined cross reference social security administration death master file development end stage cross reference united states renal data systemof 109285 participants 28244 26 chronic kidney disease defined albuminuria estimated glomerular filtration rate egfr 60 mlmin173 m2 9 n2660 reported aware kidney disease compared aware participants aware chronic kidney disease lower egfr 49 vs 62 mlmin173 m2 higher prevalence albuminuria 52 vs 46 diabetes 47 vs 42 cardiovascular disease 43 vs 28 cancer 23 vs 14 85 years followup aware participants compared unaware lower rate survival end stage 83 96 mortality 78 vs 81 p 001 adjustment demographics socioeconomic factors comorbidity severity kidney disease aware participants continued demonstrate increased risk endstage renal disease hazard ratio 137 95 confidence interval 107175 p 0123 mortality hazard ratio 127 95 confidence interval 107152 p 0077 relative unaware participants chronic kidney diseaseamong patients identified chronic kidney disease health screening small proportion made aware diagnosis previously clinicians subgroup disproportionately high risk mortality endstage renal disease