Peng Li|Ing?Tsung Hsiao|Chia-Yih Liu|Chia?Hsiang Chen|Sheng?Yao Huang|Tzu?Chen Yen|Kuan?Lin Wu|Kun-Ju Lin
Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study
Chang Gung University|Chang Gung Memorial Hospital|Chang Gung Memorial Hospital|Chang Gung University|Chang Gung Memorial Hospital|Chang Gung University|Chang Gung Memorial Hospital|Chang Gung Memorial Hospital|Chang Gung Memorial Hospital|Chang Gung University|Chang Gung Memorial Hospital|Chang Gung University
lack treatment response patients latelife depression common role brain betaamyloid deposition treatment outcome subjects latelife depression remains unclear present study aimed investigate brain deposition patients major depressive disorder mdd differing treatment outcomes vivo using 18fflorbetapir imaging study included 62 mdd patients 18 healthy control subjects hcswe first employed maudsley staging method msm categorize mdd patients two groups according treatment response mild treatment resistance n 29 moderatetosevere treatment resistance n 33the standard uptake value ratio suvr volume interest analysed voxelwise comparisons made mdd patients hcs vascular risk factors serum homocysteine level apolipoprotein e apoe genotype also determined mdd patients moderatetosevere treatment resistance higher 18fflorbetapir suvrs hcs parietal region p 001 voxelwise comparisons demonstrated elevated suvrs mdd patients moderatetosevere treatment resistance precuneus parietal temporal occipital regions mdd patients mild treatment resistance found increased 18fflorbetapir uptake mainly left frontal parietal regions compared hcs addition voxeltovoxel correlation analysis showed brain deposition correlated positively msm score occipital region 18fflorbetapir suvrs correlated negatively mini mental status examination mmse score sample mdd patients r 0355 p 0005 study provided preliminary evidence regionspecific deposition present mdd patients especially moderatetosevere treatment resistance depressive symptoms may represent prodromal manifestations alzheimers disease ad depressive symptomatology old age particularly subjects poor treatment response may underscore early changes adrelated pathophysiology