Harry Wu|Lisa Kouladjian O’Donnell|Kenji Fujita|Nashwa Masnoon|Sarah N. Hilmer
Deprescribing in the Older Patient: A Narrative Review of Challenges and Solutions
Royal North Shore Hospital|University of Sydney|Royal North Shore Hospital|University of Sydney|Royal North Shore Hospital|University of Sydney|Royal North Shore Hospital|University of Sydney|Royal North Shore Hospital|University of Sydney
abstract polypharmacy major challenge healthcare older people associated increased risks adverse outcomes delirium falls frailty cognitive impairment hospitalization significant public professional interest role deprescribing reducing medicationrelated harms older people aim provide narrative review 1 safety efficacy deprescribing interventions 2 challenges solutions deprescribing research implementation clinical practice 3 benefits using computerized clinical decision support systems ccdss quality indicators qis deprescribing research practice deprescribing established management strategy minimize polypharmacy potentially inappropriate medications limited clinical evidence efficacy global geriatric outcomes various challenges patient healthcare professional healthcare system levels may impact success deprescribing interventions research practice management strategies target levels healthcare system required overcome challenges future studies may consider large multicenter prospective designs establish effects sustainability deprescribing interventions clinical outcomes keywords deprescribing polypharmacy geriatric older people computerized clinical decision support quality indicator