Simon Brooker|Charles Mwandawiro|Katherine E. Halliday|Sammy M. Njenga|Carlos Mcharo|Paul M. Gichuki|Beatrice Wasunna|Jimmy Kihara|Doris Njomo|Dorcas Alusala|Athuman Nyae Chiguzo|Hugo C. Turner|Caroline Teti|Claire Gwayi-Chore|Birgit Nikolay|James E. Truscott|T. Déirdre Hollingsworth|Dina Balabanova|Ulla K. Griffiths|Matthew C. Freeman|Elizabeth Allen|Rachel L. Pullan|Roy M. Anderson
Interrupting transmission of soil-transmitted helminths: a study protocol for cluster randomised trials evaluating alternative treatment strategies and delivery systems in Kenya
London School of Hygiene & Tropical Medicine|Kenya Medical Research Institute|London School of Hygiene & Tropical Medicine|Kenya Medical Research Institute|Practical Action|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Kenya Medical Research Institute|Ministry of Health|Kenya School of Government|London Centre for Neglected Tropical Disease Research|Imperial College London|Practical Action|Practical Action|London School of Hygiene & Tropical Medicine|London Centre for Neglected Tropical Disease Research|Imperial College London|University of Warwick|Faculty of Public Health|London School of Hygiene & Tropical Medicine|Faculty of Public Health|London School of Hygiene & Tropical Medicine|Emory University|London School of Hygiene & Tropical Medicine|London School of Hygiene & Tropical Medicine|London Centre for Neglected Tropical Disease Research|Imperial College London
recent years unprecedented emphasis given control neglected tropical diseases including soiltransmitted helminths sths mainstay sth control schoolbased deworming sbd mathematical modelling shown low transmission settings sbd unlikely interrupt transmission new treatment strategies required study seeks answer question possible interrupt transmission sth costeffective treatment strategy delivery system achieve goaltwo cluster randomised trials implemented contrasting settings kenya interventions annual mass anthelmintic treatment delivered preschool schoolaged children part national sbd programme entire communities delivered community health workers allocation study group cluster using predefined units used public health provisiontermed community units cus cus randomised one three groups receiving either 1 annual sbd 2 annual communitybased deworming cbd 3 biannual cbd primary outcome measure prevalence hookworm infection assessed four crosssectional surveys secondary outcomes prevalence ascaris lumbricoides trichuris trichiura intensity species infections treatment coverage costs costeffectiveness evaluated among random subsample participants worm burden proportion unfertilised eggs assessed longitudinally nested process evaluation using semistructured interviews focus group discussions stakeholder analysis investigate community acceptability feasibility scaleup delivery systemstudy protocols reviewed approved ethics committees kenya medical research institute national ethics review committee london school hygiene tropical medicine study dedicated web sitenct02397772