Massimo Stella, Trevor J Swanson, Ying Li, Thomas T Hills, Andreia S Teixeira
Cognitive networks detect structural patterns and emotional complexity in suicide notes
Frontiers in psychology
population pharmacokinetics pk exposureresponse er analyses conducted compare pk er relationships golimumab children adults ulcerative colitis pk data following subcutaneous golimumab administration children ulcerative colitis 617 years pursuitpedspk study adults ulcerative colitis pursuit study children pediatric polyarticular juvenile idiopathic arthritis 217 years gokids study included population pk analysis er analysis conducted using logistic regression link serum golimumab concentration mayo scorebased efficacy outcomes pediatric adult ulcerative colitis golimumab pk adequately described 1compartment model firstorder absorption elimination golimumab apparent clearance volume distribution increased body weight golimumab apparent clearance higher patients lower serum albumin methotrexate use positive antibodies golimumab age influential factor accounting body weight modelestimated terminal halflife 92 days children 95 days adults pk parameters suggest golimumab pk properties generally comparable children adults ulcerative colitis simulations suggest higher induction dose tested pursuitpedspk may needed children 45 kg achieve exposures comparable adults comparable er relationships children adults ulcerative colitis observed although children appeared responsive stringent remission end point overall comparable pk er relationships children adults support extrapolation golimumab efficacy adult pediatric ulcerative colitis population