Roy Rillera Marzo, Ritankar Chakraborty, Shean Yih Soh, Hui Zhu Thew, Collins Chong, Ching Sin Siau, Khairuddin Bin Abdul Wahab, Indang Ariati Binti Ariffin, Shekhar Chauhan, Ken Brackstone, Bijaya Kumar Padhi, Petra Heidler
Factors influencing parents' hesitancy to vaccinate their children aged 5-11 years old against COVID-19: results from a cross-sectional study in Malaysia
Frontiers in public health
major surgical procedures associated significant bleeding risk infectious complications patients hemophilia may minimized factor replacement monitoring perioperative factor levels guides dosing maintain adequate levels hemostatic control report prospectively collected post hoc surgical data patients hemophilia b underwent major surgery extended halflife recombinant factor ix fc fusion protein rfixfc phase 3 studies blongkids blong byond achieved fix plasma levels described underwent major surgeries 1 peak andor predose fix assessment available day surgery day 0 d0 central laboratory dosing injection frequency adverse events hemostatic responses assessed two representative cases described including blood loss transfusions concomitant medication assessment 35 major surgeries 17 n 16 subjects sufficient fix measurements included analysis 13 17 surgeries orthopedic d0 median loading preoperative dose 1011 international units iukginjection achieved median peak fix 1033 iudl across postoperative days 1 3 4 6 7 14 median predose levels 751 iudl 1 injectiond 716 iudl 0 1 injectiond 432 iudl 0 1 injectiond respectively hemostasis rated excellent 14 16 good 2 16 across surgeries case studies knee arthroscopy ankle fusion illustrate measured fix levels rfixfc aggregate analysis representative cases major surgeries demonstrate rfixfc achieve fix levels effective hemostasis invasive highrisk procedures