Avshalom Caspi|Terrie E. Moffitt
All for One and One for All: Mental Disorders in One Dimension
Duke University|Duke University
child adult psychiatry empirical evidence accrued suggest single dimension able measure persons liability mental disorder comorbidity among disorders persistence disorders time severity symptoms single dimension general psychopathology termed p conceptually parallels dimension already familiar behavioral scientists clinicians g factor general intelligence g dimension reflects low high mental ability p dimension represents low high psychopathology severity thought disorder extreme dimension p unites disorders influences presentabsent status hundreds psychiatric symptoms modern nosological systems typically aggregate dozens distinct diagnoses turn aggregate three overarching domains namely externalizing internalizing psychotic experience domains finally aggregate one dimension psychopathology low high p studies show higher person scores p worse person fares measures family history psychiatric illness brain function childhood developmental history adult life impairment dimension p may help account ubiquitous nonspecificity psychiatry multiple disorders share risk factors biomarkers often respond therapies authors summarize history unidimensional idea review modern research p demystify statistical models articulate implications p prevention clinical practice outline transdiagnostic research agenda ajp 175 remembering past envision future october 1910 study association insanity grace helen kent aj rosanoff