Gildàsio S. De Oliveira|Lucas J. Castro Alves|Autoun Nader|Mark C. Kendall|Rohit Rahangdale|Robert J. McCarthy
Perineural Dexamethasone to Improve Postoperative Analgesia with Peripheral Nerve Blocks: A Meta-Analysis of Randomized Controlled Trials
Northwestern University|Northwestern University|Northwestern University|Northwestern University|Northwestern University|Northwestern University
background overall effect perineural dexamethasone postoperative analgesia outcomes yet quantified main objective quantitative review evaluate effect perineural dexamethasone nerve block adjunct postoperative analgesia outcomes methods systematic search performed identify randomized controlled trials evaluated effects perineural dexamethasone block adjunct postoperative pain outcomes patients receiving regional anesthesia metaanalysis performed using randomeffect model results nine randomized trials 760 subjects included weighted mean difference 99 ci combined effects favored perineural dexamethasone control analgesia duration 473 264 682 minutes motor block duration 500 154 846 minutes postoperative opioid consumption also reduced perineural dexamethasone group compared control 85 123 46 mg iv morphine equivalents significant neurological symptoms could attributed use perineural dexamethasone conclusions perineural dexamethasone improves postoperative pain outcomes given adjunct brachial plexus blocks reports persistent nerve injury attributed perineural administration drug