John P. Marinelli|Christine M. Lohse|Matthew L. Carlson
Incidence of Vestibular Schwannoma over the Past Half?Century: A Population?Based Study of Olmsted County, Minnesota
Mayo Clinic|Mayo Clinic in Florida|Mayo Clinic
objective absence centralized health system limited epidemiologic research surrounding vestibular schwannoma vs united states rochester epidemiology project rep comprises unique medical consortium covers complete population ages welldefined geographic region past halfcentury objective study characterize incidence sporadic vs extended period study design populationbased study setting olmsted county minnesota subjects methods review vss diagnosed january 1 1966 december 31 2016 conducted rep medical records linkage system results total 153 incident cases vs identified incidence vs significantly increased past halfcentury 15 per 100000 personyears first decade 42 last decade p lt 001 incidence increased age p lt 001 aged 70 years exhibited highest incidence rate 183 per 100000 personyears last decade age diagnosis significantly increased median 52 years first decade 62 years last p lt 001 despite presenting fewer symptoms smaller tumors time delay symptom onset diagnosis significantly decreased past 5 decades p lt 05 almost 1 4 patients diagnosed incidentally last decade conclusion incidence vs increased significantly past halfcentury rate greater previously reported patients ease access medical care olmsted county comprehensive rep system likely contributed elevated detection rate vs