Nicholas Wright|Louis Wilson|Morgen Smith|Bruce Bartholow Duncan|Patrick McHugh
The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes
Royal New Zealand College of General Practitioners|Toi Ohomai Institute of Technology|University of Otago
abstract backgroundobjective little randomised evidence using whole food plantbased wfpb diet intervention elevated body mass index bmi dyslipidaemia investigated effectiveness communitybased dietary programme primary end points bmi cholesterol 6 months subsequently extended subjects ages 3570 one general practice gisborne new zealand diagnosed obesity overweight least one type 2 diabetes ischaemic heart disease hypertension hypercholesterolaemia 65 subjects randomised control n 32 intervention n 33 49 754 completed study 6 months twentythree 70 intervention participants followed 12 months methods participants received normal care intervention participants attended facilitated meetings twiceweekly 12 weeks followed nonenergyrestricted wfpb diet vitamin b 12 supplementation results 6 months mean bmi reduction greater wfpb diet compared normal care 44 vs 04 difference 39 kg 2 95 confidence interval ci1 p lt00001 mean cholesterol reduction greater wfpb diet difference significant compared normal care 071 vs 026 difference 045 mmol l 1 95 ci054 p 01 unless dropouts excluded difference 056 mmol l 1 95 ci054 p 005 twelvemonth mean reductions wfpb diet group 42 08 kg 2 bmi points 055 054 p 005 mmol l 1 total cholesterol serious harms reported conclusions programme led significant improvements bmi cholesterol risk factors best knowledge research achieved greater weight loss 6 12 months trial limit energy intake mandate regular exercise