Katarzyna Bobrowicz, Areum Han, Jennifer Hausen, Samuel Greiff
Corrigendum: Aiding Reflective Navigation in a Dynamic Information Landscape: A Challenge for Educational Psychology
Frontiers in psychology
presence portal vein tumor thrombus pvtt significant indicator advancedstage hepatocellular carcinoma hcc unfortunately prediction pvtt occurrence remains challenging lack comprehensive research exploring underlying mechanisms pvtt formation association immune infiltration approach involved analyzing singlecell sequencing data applying high dimensional weighted gene coexpression network analysis hdwgcna identifying key genes associated pvtt development furthermore constructed competing endogenous rna cerna networks employed weighted gene coexpression network analysis wgcna well three machinelearning techniques identify upstream regulatory micrornas mirnas long noncoding rnas lncrnas crucial mrnas employed fuzzy clustering time series gene expression data mfuzz gene set variation analysis gsva cell communication analysis uncover significant signaling pathways involved activation important mrnas pvtt development addition conducted immune infiltration analysis survival typing drug sensitivity analysis using cancer genome atlas tcga cohort gain insights two patient groups study implementation hdwgcna identified 110 genes closely associated pvtt among genes tmem165 emerged crucial candidate investigated significance using cox regression analysis furthermore machine learning techniques survival analysis successfully identified upstream regulatory mirna hsamir148a lncrna linc00909 targeted tmem165 findings shed light complex regulatory network surrounding tmem165 context pvtt moreover conducted cibersort analysis unveiled correlations tmem165 immune infiltration hcc patients specifically tmem165 exhibited associations various immune cell populations including memory b cells cd8 cells additionally observed implications immune function particularly relation immune checkpoints within context hcc regulatory axis involving tmem165 hsamir148a linc00909 emerges crucial determinant development pvtt hcc patients holds significant implications prognosis furthermore alterations tmem165hsamir148alinc00909 regulatory axis exhibit strong correlation immune infiltration within hcc tumor microenvironment leading immune dysfunction potential failure immunotherapy