Laura Betancur, Elizabeth Votruba-Drzal, Christian Schunn
Socioeconomic gaps in science achievement
International journal of STEM education
contact topology protein determines important aspects folding process topological measure contact order shown predictive rate folding circuit topology emerging another fundamental descriptor biomolecular structure predicted effects folding rate analyze residuebased circuit topological environments 21 k mutations labeled pathogenic benign multiple statistical lines reasoning support conclusion number contacts two specific circuit topological arrangements namely inverse parallel cross relations contacts involving mutated residue discriminatory value determining pathogenicity human variants investigate results vary residue type according whether gene essential explore relationship number structural features find circuit topology provides nonredundant information protein structures pathogenicity mutations results may implications polymer physics protein folding suggest local topological information including residuebased circuit topology residue contact order could useful improving stateoftheart machine learning algorithms pathogenicity prediction