Sharon D Horner, Adama Brown, Sharon A Brown, D Lynn Rew
Enhancing Asthma Self-Management in Rural School-Aged Children: A Randomized Controlled Trial
The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association
sickle cell disease scd common inherited singlegene disease complications include chronic anaemia reduced oxygencarrying capability cerebral vasculopathy resulting silent cerebral infarction stroke cognitive dysfunction impairments measures executive function attention reasoning language memory iq systematic review aims investigate association neuroimaging findings cognition children scd searches pubmed embase conducted march 2022 studies included participants 18 years original data published english 1960 2022 genotype scd included relationship cognition neuroimaging examined exclusion criteria included case studies editorials reviews quality assessed using critical appraisal skills programme case control checklist total 303 articles retrieved 33 met eligibility criteria presence overt silent strokes elevated blood flow velocities abnormal functional connectivity decreased fmri activation associated neuropsychological deficits children scd compared controls critical need address disease manifestations scd early damage appears begin young age studies crosssectional restricting interpretation directionality relationships future research employing longitudinal neuroimaging neuropsychological assessments could improve understanding cumulative consequences scd developing brain