Catherine Jurd, Jennieffer Barr
Leadership factors for cardiopulmonary resuscitation for clinicians in-hospital; behaviours, skills and strategies: A systematic review and synthesis without meta-analysis
Journal of clinical nursing
men high serum prostate specific antigen usually undergo transrectal ultrasoundguided prostate biopsy trusbiopsy trusbiopsy cause sideeffects including bleeding pain infection multiparametric magnetic resonance imaging mpmri used triage test might allow men avoid unnecessary trusbiopsy improve diagnostic accuracywe multicentre pairedcohort confirmatory study test diagnostic accuracy mpmri trusbiopsy reference test template prostate mapping biopsy tpmbiopsy men prostatespecific antigen concentrations 15 ngml previous biopsy underwent 15 tesla mpmri followed trusbiopsy tpmbiopsy conduct reporting test done blind test results clinically significant cancer defined gleason score 4 3 maximum cancer core length 6 mm longer study registered clinicaltrialsgov nct01292291between may 17 2012 november 9 2015 enrolled 740 men 576 underwent 15 tesla mpmri followed trusbiopsy tpmbiopsy tpmbiopsy 408 71 576 men cancer 230 40 576 patients clinically significant clinically significant cancer mpmri sensitive 93 95 ci 8896 trusbiopsy 48 4255 p00001 less specific 41 3646 mpmri vs 96 9498 trusbiopsy p00001 44 59 740 patients reported serious adverse events including 8 cases sepsisusing mpmri triage men might allow 27 patients avoid primary biopsy diagnosis 5 fewer clinically insignificant cancers subsequent trusbiopsies directed mpmri findings 18 cases clinically significant cancer might detected compared standard pathway trusbiopsy mpmri used triage test first prostate biopsy could reduce unnecessary biopsies quarter mpmri also reduce overdiagnosis clinically insignificant prostate cancer improve detection clinically significant cancerpromis funded uk government department health national institute health researchhealth technology assessment programme project number 092267 project also supported partly funded uclhucl biomedical research centre royal marsden institute cancer research biomedical research centre coordinated medical research council clinical trials unit mrc ctu ucl sponsored university college london ucl