Jo Ann M Farver, Yiyuan Xu, Christopher J Lonigan, Stefanie Eppe
The home literacy environment and Latino head start children's emergent literacy skills
Developmental psychology
evolutionary conserved notch signaling pathway functions mediator direct cellcell communication neighboring cells development notch plays crucial role various fundamental biological processes wide range tissues accordingly aberrant signaling pathway underlies multiple genetic pathologies developmental syndromes congenital disorders neurodegenerative diseases cancer last two decades significant data shown notch signaling pathway displays significant function mature brains vertebrates invertebrates beyond neuronal development specification embryonic development neuronal connection synaptic plasticity learning memory appear regulated pathway specific mutations human notch family proteins linked several neurodegenerative diseases including alzheimers disease cadasil ischemic injury neurodegenerative diseases incurable disorders central nervous system cause progressive degeneration andor death brain nerve cells affecting mental function movement ataxia currently lot study conducted better understand molecular mechanisms notch plays essential role mature brain study silico analysis polymorphisms mutations human notch family members lead neurodegenerative diseases performed order investigate correlations among notch family proteins neurodegenerative diseases particular emphasis placed study mutations notch3 protein structure analysis mutant notch3 protein leads manifestation cadasil syndrome order spot possible conserved mutations interpret effect mutations notch3 protein structure conserved mutations cysteine residues may candidate pharmacological targets potential therapy cadasil syndrome