Kristine Yaffe|Daniel Freimer|Honglei Chen|Keiko Asao|Andrea L. Rosso|Susan M. Rubin|Greg Tranah|Steve Cummings|Eleanor M. Simonsick
Olfaction and risk of dementia in a biracial cohort of older adults
University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|University of Pittsburgh|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|University of Pittsburgh|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh|University of Tennessee Health Science Center|National Institute of Environmental Health Sciences|San Francisco VA Medical Center|Northern California Institute for Research and Education|California Pacific Medical Center|University of California, Los Angeles|National Institute on Aging|University of Pittsburgh
prior studies indicate olfactory function may early marker cognitive impairment body evidence largely restricted white populationswe studied 2428 communitydwelling black white older adults baseline age 7079 years without dementia enrolled health aging body composition health abc study olfaction measured odor identification oi 12item cross cultural smell identification test year 3 defined incident dementia 12 years basis hospitalization records prescription dementia medication 15sd decline racestratified global cognition score assessed dementia risk associated oi score tertile using cox proportional hazards models analyses stratified racepoorer oi older adults without dementia associated increased risk dementia adjustment demographics medical comorbidities lifestyle characteristics white participants poor moderate oi tertile greater risk dementia adjusted hazard ratio hr 334 95 confidence interval ci 245454 hr 184 95 ci 133254 respectively compared good tertile function among blacks worse oi associated increased risk dementia magnitude effect weaker p interaction 004 poor oi tertile adjusted hr 203 95 ci 144284 moderate tertile adjusted hr 142 95 ci 097210 interaction oi apoe 4 risk dementiawhile magnitude association stronger whites found poor oi associated increased risk dementia among black white older adults