Hui-Chuan Hsu, Shu-Ching Chang, Chun-Yu Liang, Jie-Rong Ting
Intervention to reduce loneliness among older adults in the community: Making friends with volunteers
Geriatrics & gerontology international
autism spectrum disorder asd highly heritable heterogeneous neurodevelopmental disorder characterized impaired social interactions repetitive behaviors wide range comorbidities 4483 autistic individuals report sleep disturbances may share underlying neurodevelopmental basis asd recruited 382 asd individuals 223 family members obtain quantitative asdrelated traits wearable devicebased accelerometer data spanning three consecutive weeks unbiased approach identifying traits associated asd achieved applying elastic net machine learning algorithm fivefold crossvalidation 6878 days data relationship sleep physical activity traits examined linear mixedeffects regressions using night data analysis yielded 59 242 actimetry measures associated asd status training set validated test set auc 0777 several traits eg total light physical activity daytoday variability addition mean associated asd individuals asd found stronger correlation physical activity sleep less physical activity decreased sleep significantly nonasd relatives average duration sleepphysical activity variation average duration sleepphysical activity strongly predict asd status physical activity measures correlated sleep quality traits regularity asd individuals stronger correlations interventional studies warranted investigate whether improvements sleep increased physical activity may improve core symptoms asd