Jennifer Y Oshita, Nancy M Gell, Michelle L Stransky, Nicholas S Reed, Charles D MacLean
Prevalence and sociodemographic characteristics of US community-dwelling older adults with communication disabilities, using the national health and aging trends survey
Journal of communication disorders
acute respiratory distress syndrome ards heterogeneous condition two subphenotypes identified different methodologies group similarly identified two ards subphenotypes using nine routinely available clinical variables however whether associated differential response treatment yet explored differential responses positive endexpiratory pressure peep strategies 28day mortality according subphenotypes adult patients ards evaluated data two prior ards trials alveoli art compared different peep strategies classified patients one two subphenotypes previously described assessed differential effect peep bayesian hierarchical logistic model primary outcome 28day mortality analyzed data 1559 ards patients compared lower peep higher peep strategy resulted higher 28day mortality subphenotype patients alveoli 161 95 cri 090 294 art 173 95 cri 101 298 probability harm higher peep subphenotype 943 977 alveoli art respectively higher peep associated mortality subphenotype b patients trial 095 95 cri 051 173 100 95 cri 063 155 probability benefit 564 507 alveoli art respectively effects modified pao2fio2 ratio driving pressure severity illness cohorts found evidence differential response peep strategies across two ards subphenotypes suggesting possible harm higher peep strategy one subphenotype observations may assist predictive enrichment future clinical trials