Yumi Dille, Lieven Lagae, Ann Swillen, Griet Van Buggenhout
Neurodevelopmental profile and stages of regression in Phelan-McDermid syndrome
Developmental medicine and child neurology
study uses administrative data assess optimal timing surgical repair craniosynostosis identify factors associated risk perioperative complications statistical analysis healthcare cost utilization project kids inpatient database 2006 2009 2012 kidparticipating hospitals 44 states children 0 3 years age icd9 codes surgical correction craniosynostosis 756 0124 0125 0201 0203 0204 0206 agebased cohorts assessed perioperative complications performed multivariable analysis determine characteristics associated increased risk complications 21 million admissions screened 8417 visits met criteria inclusion seventyfive percent procedures occurred age 1 complications occurred 86 patients 66 patients age 0 6 months 103 patients aged 7 12 months 139 patients 12 36 months patients acrocephalosyndactyly associated congenital anomalies experienced complications 229 cases 307 95 ci 233 403 craniosynostosis repair safe however risk complications increases age intervention presence syndromic congenital deformity age carries greatest increased risk perioperative complications suggests optimal timing intervention within first year life especially cases additional factors increasing perioperative risk data support importance counseling patients increased risk associated delaying craniosynostosis repair