Jang-Sik Ko, Seon-Rye Kim, Byung-Jun Cho
The Effect of Cardiopulmonary Resuscitation (CPR) Education on the CPR Knowledge, Attitudes, Self-Efficacy, and Confidence in Performing CPR among Elementary School Students in Korea
Healthcare (Basel, Switzerland)
2023 danish covid19 vaccination campaign updated monovalent mrna vaccine targeting sarscov2 omicron xbb15 subvariant administered however rapid spread genetically divergent omicron ba286 subvariant jn1 since september 2023 poses potential challenges due rapid dominance possible immune escape using national electronic health registry data regions denmark aimed investigate whether sarscov2 subvariant ba286 descendant jn1 differed circulating variants terms ability escape vaccine protection risk infection leading severe disease selfreported symptoms among infected people observational study included residents denmark aged 65 years older tested positive sarscov2 pcr oct 1 dec 31 2023 genomic data sarscov2 variant caused infection available data clinical testing sentinel selfsamplingbased surveillance linked national electronic civil vaccination hospitalisation registers relative protection xbb15 updated covid19 vaccine ba286 infections versus infections variants analysed caseonly study relative risk hospitalisation people infected ba286 versus variants analysed casecontrol study analyses adjusted time comorbidities previous vaccination history among potential confounders additionally prevalence patterns selfreported symptoms among people ages infected sarscov2 reported separately subvariant 7581 people denmark aged 65 years older tested positive sarscov2 pcr study period 5882 78 samples eligible sequencing 3862 66 passed quality control successfully sequenced sarscov2 variant subvariant identified individuals included study 3862 people 2184 57 infected ba286 subvariant including 1615 jn1 infections participants infected ba286 152 95 ci 125186 times odds infected jn1 160 127202 times odds received xbb15 vaccine least 7 days infection compared participants infected nonba286 variant severity analysis showed evidence association infecting variant risk covid19 hospitalisation odds ratio 104 95 ci 086126 ba286 107 085134 jn1 similarly evidence differences selfreported symptoms variant strain compared sarscov2 variants ba286 jn1 sublineage less sensitive vaccineinduced immune protection xbb15 updated covid19 vaccine however found evidence infection ba286 jn1 resulted increased disease severity different symptom profiles although less effective new variants xbb15 vaccination remains protective reduces risk infection covid19 disease danish government eus eu4health programme