Viskasari Pintoko Kalanjati, Nurina Hasanatuludhhiyah, Annette d'Arqom, Danial H Arsyi, Ancah Caesarina Novi Marchianti, Azlin Muhammad, Diana Purwitasari
Sentiment analysis of Indonesian tweets on COVID-19 and COVID-19 vaccinations
F1000Research
choline essential healthy cognitive development single nucleotide polymorphisms snps rs3199966g rs2771040g within choline transporter slc44a1 increase risk choline deficiency choline intervention trial children experienced prenatal alcohol exposure pae alleles associated improved cognition study aimed determine snps within slc44a1 differentially associated cognition children pae compared normotypic controls genotype exposure secondary objective tested association snps cognition controls genotypeonly secondary analysis data collaborative initiative fetal alcohol spectrum disorders participants 163 normotypic controls 162 pae underwent psychological assessments genotyped within slc44a1 choline status assessed association analysis genotype exposure performed using additive genetic model linear regression identify allelic effect primary outcome interaction slc44a1 genotype exposure status respect cognition secondary outcome cognitivegenotype association normotypic controls genotype exposure analysis identified 7 snps slc44a1 including rs3199966g rs2771040g strong linkage 087 associated adjusted p 005 reduced performance measures general cognition nonverbal quantitative reasoning memory executive function 192391 controls carriers rs3199966gt gg worsened cognitive performance rs3199966tt carriers 046083 p 00001 whereas cognitive performance differ rs3199966 genotype pae two functional alleles increase vulnerability choline deficiency rs3199966g ser644ala rs2771040g 3 untranslated region associated worsened cognition otherwise normotypic children alleles previously associated greater cognitive improvement children pae received supplemental choline findings endorse choline benefits cognitive development normotypic children pae