Cortino Sukotjo, Merve Koseoglu, Pitcha Suwannasin, Judy Chia-Chun Yuan, Yoon Soo Park, Bradford Ray Johnson, Kewalin Thammasitboon, Ara Tekian
Assessing methodological quality in dental education research using MERSQI: Analysis of publications from two journals
Journal of dental education
black patients heart failure poorer prognosis white patients difference adequately explained whether racial differences response drug treatment contribute differences outcome unclear address issue pooled analyzed data studies left ventricular dysfunction solvd prevention treatment trials two large randomized trials comparing enalapril placebo patients left ventricular dysfunctionwe used matchedcohort design four white patients matched black patient according trial treatment assignment sex left ventricular ejection fraction age total 1196 white patients 580 prevention trial 616 treatment trial matched 800 black patients 404 prevention trial 396 treatment trial average duration followup 35 months prevention trial 33 months treatment trialthe black patients matched white patients similar demographic clinical characteristics black patients higher rates death cause 122 vs 97 per 100 personyears hospitalization heart failure 132 vs 77 per 100 personyears despite similar doses drug two groups enalapril therapy compared placebo associated 44 percent reduction 95 percent confidence interval 27 57 percent risk hospitalization heart failure among white patients p0001 significant reduction among black patients p074 one year enalapril therapy associated significant reductions base line systolic blood pressure mean sd 50171 mm hg diastolic blood pressure 36106 mm hg among white patients among black patients significant change risk death observed association enalapril therapy either groupenalapril therapy associated significant reduction risk hospitalization heart failure among white patients left ventricular dysfunction among similar black patients finding underscores need additional research efficacy therapies heart failure black patients