Sarah E. MacPherson|Colm Healy|Michael Allerhand|Barbara Spanò|Carina Tudor-Sfetea|Mark White|Daniela Smirni|Tim Shallice|Edgar Chan|Marco Bozzali|Lisa Cipolotti
Cognitive reserve and cognitive performance of patients with focal frontal lesions
University of Edinburgh|National Hospital for Neurology and Neurosurgery|University College London|University of Edinburgh|Fondazione Santa Lucia|National Hospital for Neurology and Neurosurgery|University College London|National Hospital for Neurology and Neurosurgery|University College London|University of Palermo|University College London|Scuola Internazionale Superiore di Studi Avanzati|National Hospital for Neurology and Neurosurgery|University College London|Fondazione Santa Lucia|National Hospital for Neurology and Neurosurgery|University College London|University of Palermo
cognitive reserve cr hypothesis put forward account variability cognitive performance patients similar degrees brain pathology compensatory neural activity within frontal lobes often associated cr first time investigated independent effects two cr proxies education nart iq measures executive function fluid intelligence speed information processing verbal short term memory vstm naming perception sample 86 patients focal unilateral frontal lesions 142 healthy controls fitted multiple linear regression models cognitive measures found nart iq predicted executive naming performance neither education nart iq predicted performance fluid intelligence processing speed vstm perceptual abilities education nart iq modify effect lesion severity cognitive impairment also found age significantly predicted performance executive tests majority cognitive measures except vstm gnt age predictor fluid intelligence latter finding suggests age plays role executive performance contribution cr proxies patients focal frontal lesions overall results suggest cr proxies appear modify relationship cognitive impairment frontal lesions