Norhidayu Sahimin, Zhao Xuan Low, Pouya Hassandarvish, Izzah Ruzana Mohd Hanapi, Siti Nursheena Mohd Zain, Hasmawati Yahaya, Sazaly Abu Bakar
Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia
Transactions of the Royal Society of Tropical Medicine and Hygiene
brainderived neurotrophic factor bdnf neurotransmitter modulator plays significant role neuronal survival growth participates neuronal plasticity thus essential learning memory development cognition additionally crucial appetite weight metabolic control plays pivotal role cardiovascular system val66met polymorphism rs6265 bdnf gene causes decrease bdnf secretion plays role impairments cognition energy homeostasis cardiovascular events present study aimed evaluate association polymorphism rs6265 bdnf gene three quantitative traits simultaneously namely intelligence quotient iq body mass index bmi blood pressure bp psychometric morphometric physiometric data total participants n 246 collected wasiiiindia used measure cognitive ability genotyping carried using allelespecific pcr rs6265 polymorphism c196t genotypes determined statistical analyses performed p 005 significance level using msexcel sigmaplot odds ratio models 95 confidence interval used test associations used models codominant recessive dominant overdominant additive allelic frequencies alleles c 72 28 respectively dominant genetic model significant susceptible association minor allele observed lower average verbal comprehensive index 2216 p 0003 ci 95 133369 lower average performance reasoning index 2634 p 0001 ci 95 1573441 lower average fullscale iq4 3159 p 0001 ci 95 18735328 carriers metalleles found increased body mass index 2538 p 0001 ci 95 15074275 decreased systolic blood pressure 2051 p 0012 ci 95 12023502 decreased diastolic blood pressure 2162 p 0006 ci 95 12783657 recessive genetic model several folds decrease iq bp increase bmi presence allele also detected novel study may improve understanding genetic alterations traits hence helpful clinicians researchers investigate diagnostic prognostic value neurotrophic factor