Yaakov Stern|Christian Habeck|James R. Moeller|Nikolaos Scarmeas|Karen E. Anderson|Holly Hilton|Joseph Flynn|Harold A. Sackeïm|Ronald Van Heertum
Brain Networks Associated with Cognitive Reserve in Healthy Young and Old Adults
Columbia University
order understand brain networks mediate cognitive reserve explored relationship subjects network expression performance memory test index cognitive reserve using h215o positron emission tomography imaged 17 healthy older subjects 20 young adults performed serial recognition memory task nonsense shapes two conditions low demand unique shape presented study trial titrated demand study list size adjusted subject recognized shapes 75 accuracy factor score summarized years education scores nart waisr vocabulary subtest used index cognitive reserve scaled subprofile model used identify set functionally connected regions topography changed expression across two task conditions differentially expressed young elderly subjects regions active topography consisted right hippocampus posterior insula thalamus right left operculum found concomitant deactivation right lingual gyrus inferior parietal lobe association cortex left posterior cingulate right left calcarine cortex young subjects higher cognitive reserve showed increased expression topography across two task conditions topography responsive increased task demands differentially expressed function reserve level may represent neural manifestation innate acquired reserve contrast older subjects higher cognitive reserve showed decreased expression topography across tasks suggests functional reorganization network used young subjects thus old subjects topography may represent altered compensatory network used maintain function face agerelated physiological changes