Vimla Lodhia Patel, Mariel Halpern, Vijayalakshmi Nagaraj, Odille Chang, Sriram Iyengar, William May
Information processing by community health nurses using mobile health (mHealth) tools for early identification of suicide and depression risks in Fiji Islands
BMJ health & care informatics
inflammageing condition perpetual lowgrade inflammation induced ageing inflammageing may predicted creactive protein crp recently described biomarker measures nglycosylated side chains carbohydrate component several acutephase proteins known glyca objective study examine depth genetic relationships crp glyca well selected cytokines may shed light mechanisms inflammageing using olink 96 inflammation panel data inflammatory mediators 1518 twins twinsuk dataset acquired summary statistics genomewide association studies several cytokines well crp glyca collected public sources extensive genetic correlation analyses colocalization genetic enrichment analyses carried detect shared genetic architecture glyca crp mendelian randomization carried assess potential causal relationships glyca predicted examined cytokines magnitude twice great crp glyca crp significantly genetically correlated rg 04397 00854 pvalue 260 107 evidence causal relationship glyca crp two biomarkers cytokines assessed obtained however aforementioned relationships explained well horizontal pleiotropy five exonic genetic variants annotated five genes explain shared genetic architecture observed glyca crp il6r gckr mlxipl serpina1 map1a glyca crp possess shared genetic architecture relationship appears modest may imply promotion differing inflammatory pathways glyca appears robust predictor cytokines compared crp