Ahmad Samed Al-Adwan, Malek Alsoud, Na Li, Tha'er Majali, Jo Smedley, Akhmad Habibi
Unlocking future learning: Exploring higher education students' intention to adopt meta-education
Heliyon
optimal amount timing protein intake critically ill patients unknown replenish replacing protein via enteral nutrition stepwise approach critically ill patients trial evaluates whether supplemental enteral protein added standard enteral nutrition achieve high amount enteral protein given icu day five icu discharge icu day 90 compared supplemental enteral protein achieve moderate amount enteral protein would reduce allcause 90day mortality adult critically ill mechanically ventilated patients multicenter randomized trial critically ill patients randomized receive supplemental enteral protein 12 gkgday added standard enteral nutrition achieve high amount enteral protein range 224 gkgday supplemental enteral protein achieve moderate amount enteral protein 0812 gkgday primary outcome 90day allcause mortality outcomes include functional healthrelated qualityoflife assessments 90 days study sample size 2502 patients 80 power detect 5 absolute risk reduction 90day mortality 30 25 consistent international guidelines statistical analysis plan specifies methods evaluating primary secondary outcomes subgroups applying statistical analysis plan replenish trial facilitate unbiased analyses clinical data ethics approval obtained institutional review board ministry national guard health affairs riyadh saudi arabia rc19414r approvals also obtained institutional review boards participating institution findings disseminated international peerreviewed journal presented relevant conferences meetings clinicaltrialsgov nct04475666 registered july 17 2020