Adelline Twimukye, Yussif Alhassan, Beate Ringwald, Thokozile Malaba, Landon Myer, Catriona Waitt, Mohammed Lamorde, Helen Reynolds, Saye Khoo, Miriam Taegtmeyer
Support, not blame: safe partner disclosure among women diagnosed with HIV late in pregnancy in South Africa and Uganda
AIDS research and therapy
multicenter early diuretic response dr analysis single furosemide dosing following neonatal cardiac surgery lacking inform whether early dr predicts adverse clinical outcomes performed retrospective cohort study utilizing data nephron registry random forest machine learning generated receiver operating characteristicarea curve rocauc odds ratios mechanical ventilation mv respiratory support rs prolonged mv rs defined using 90th percentile observedexpected ratios secondary outcomes prolonged cicu hospital length stay los kidney failure stage iii acute kidney injury aki peritoneal dialysis andor continuous kidney replacement therapy postoperative day three assessed using covariateadjusted rocauc curves total 782 children included cumulative urine output uop metrics lower prolonged mv rs patients dr poorly predicted prolonged mv highest auc 0611 098 sensitivity 067 specificity 053 p 0006 95 ci 096099 cumulative 6h uop rs highest auc 0674 094 sensitivity 075 specificity 054 p 0001 95 ci 091097 uop 3 6 h secondary outcome results similar dr fair discrimination kidney failure auc 0703 094 sensitivity 063 specificity 071 95 ci 091098 p 0001 cumulative 6h uop early dr poorly discriminated patients prolonged mv rs los cohort though may identify severe postoperative aki phenotype future work warranted determine early dr late postoperative dr later combination aki metrics may identify higherrisk phenotype