Matías Bustamante-Valdés, Danilo Díaz-Levicoy, Eduardo Alarcón-Bustamante
Analysis of Formative and Evaluative Activities on Statistical Graphs in Textbooks for Chilean Rural Multigrade Education
European journal of investigation in health, psychology and education
accurate determination human epidermal growth factor receptor 2 her2 important choosing optimal her2 targeting treatment strategies her2low currently considered her2negative patients may eligible receive new antiher2 drug conjugates use breast mri birads features classifying three her2 levels first distinguish her2zero her2lowpositive task1 distinguish her2low her2positive task2 retrospective 621 invasive ductal cancer 245 her2zero 191 her2low 185 her2positive task1 488 cases training 133 testing task2 294 cases training 82 testing 30 3d t1weighted dce short time inversion recovery t2 singleshot epi dwi pathological information birads features compared random forest used select mri features four machine learning ml algorithms decision tree dt support vector machine svm knearest neighbors knn artificial neural nets ann applied build models chisquare test oneway analysis variance kruskalwallis test performed p values 005 considered statistically significant ml models generated probability used construct roc curves peritumoral edema presence multiple lesions nonmass enhancement nme showed significant differences distinguishing her2zero nonzero low positive multiple lesions edema margin tumor size selected knn model achieved highest auc 086 training set 079 testing set differentiating her2low her2positive multiple lesions edema margin selected dt model achieved highest auc 079 training set 069 testing set birads features read radiologists preoperative mri analyzed using sophisticated feature selection ml algorithms build models classification her2 status identify her2low stage 2