Nadine Revheim|Cheryl Corcoran|Elisa C. Dias|Esther Hellmann|Ant??gona Mart??nez|Pamela D. Butler|Jonathan Lehrfeld|Joanna DiCostanzo|Jennifer Albert|Daniel C. Javitt
Reading Deficits in Schizophrenia and Individuals at High Clinical Risk: Relationship to Sensory Function, Course of Illness, and Psychosocial Outcome
ability read passages information fluently comprehension basic component socioeconomic success reading ability depends integrity underlying visual auditory phonological systems study investigated integrity reading ability schizophrenia relative integrity underlying visual auditory functionthe participants 45 schizophrenia patients 19 clinical highrisk patients 65 comparison subjects reading assessed using tests sensitive visual phonological reading dysfunction sensory neuropsychological functional outcome measures also obtainedschizophrenia patients displayed reading deficits far severe effect size 20 would predicted based general neurocognitive impairments effect size 1014 deficits correlated highly visual auditory sensory measures including impaired mismatch negativity generation r062 n51 p00002 patients established schizophrenia displayed visual phonological impairments whereas highrisk patients showed isolated visual impairments 70 schizophrenia patients met criteria acquired dyslexia 50 reading eighth grade level despite intact premorbid reading ability reading deficits also correlated significantly rp04 n30 p003 failure match parental socioeconomic achievement contributions general cognitive impairmentpatients schizophrenia display severe deficits reading ability represent potentially remediable cause impaired socioeconomic function deficits presently captured routine clinical assessment deficits likely develop years immediately surrounding illness onset may contribute reduced educational occupational achievement associated schizophrenia