Gail E. Henderson|Molly Ewing|Kristine J. Kuczynski|R. Jean Cadigan|Margaret Waltz|Rita M. Butterfield|Christine Rini|Karen E. Weck|Jonathan S. Berg|Teresa Edwards
Development and validation of a measure of comprehension of genomic screening—negative results (CoG-NR)
University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|Duke University|Northwestern University|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill|University of North Carolina at Chapel Hill
realize promise population genomic screening rare medically actionable conditions critical challenges return normalnegative results must understood overcome study objective assess functioning new 13item measure cognr understanding knowledge normalnegative genomic screening results three highly actionable conditions lynch syndrome hereditary breast ovarian cancer familial hypercholesterolemia based prior research expert review developed cognr tested well functioned using hypothetical scenarios three qualtrics surveys report psychometric properties performance across three different conditions measure performed similarly three conditions examinations item difficulty internal reliability differential item functioning indicate items perform well statistically significant positive correlations genomic knowledge health literacy objective numeracy cognr assesses understanding normalnegative results conditions next step examine performance among individuals actually undergone tests subsequent use clinical research situations cognr measure holds great promise tool enhance benefits population genomic screening bringing light prevalence incorrect interpretation negative results