J. Richard Jennings|Matthew F. Muldoon|Julie C. Price|Israel C. Christie|Carolyn C. Meltzer
Cerebrovascular Support for Cognitive Processing in Hypertensive Patients Is Altered by Blood Pressure Treatment
Emory University|University of Pittsburgh|Emory University|University of Pittsburgh|Emory University|University of Pittsburgh|Emory University|University of Pittsburgh|Emory University|University of Pittsburgh
hypertension associated mild decrements cognition addition regional cerebral blood flow responses memory processing blunted parietal thalamic areas among untreated hypertensive adults compared normotensive subjects manifest greater correlation blood flow response across taskrelated brain regions test whether pharmacological treatment hypertension normalizes regional cerebral blood flow responses whether differentially according drug class treatment lisinopril angiotensinconverting enzyme blocker known enhance vasodilative responsivity compared treatment atenolol betablocker untreated hypertensive volunteers n28 randomly assigned treated 1 year whole brain regional cerebral flow responses memory processing acutely administered acetazolamide vasodilator assessed pretreatment posttreatment peripheral brachial artery dilation reactive hyperemia also measured quantitative blood flow measures showed difference magnitude regional cerebral blood flow responses pretreatment posttreatment either memory tasks acetazolamide injection brachial artery flowmediated dilation increased treatment differences medications observed brain regions active memory processing however regional cerebral blood flow responses highly correlated treatment specificity cerebral blood flow different regions appears decline treatment hypertension greater correlation among active brain regions present well untreated hypertensive relative normotensive volunteers may represent compensation face less regionspecific responsivity individuals hypertension