Jesse Yedinak, Maxwell S Krieger, Raynald Joseph, Stacey Levin, Sarah Edwards, Dennis A Bailer, Jonathan Goyer, Colleen Daley Ndoye, Cathy Schultz, Jennifer Koziol, Rachael Elmaleh, Benjamin D Hallowell, Todd Hampson, Ellen Duong, Abdullah Shihipar, William C Goedel, Brandon Dl Marshall
Public Health Dashboards in Overdose Prevention: The Rhode Island Approach to Public Health Data Literacy, Partnerships, and Action
Journal of medical Internet research
communityacquired pneumonia cap causes around 10 hospitalisations per 1000 childyears associated average 13 nonroutine days experienced 4 parent workdays lost adults steroid treatment shortens time clinical stabilisation without increase complications patients cap however despite promising data observational studies lack highquality evidence use steroids kidsstep trial multicentre randomised doubleblind placebocontrolled superiority trial betamethasone treatment outcome hospitalised children cap children enrolled paediatric emergency departments hospitals across switzerland randomised adjunct oral betamethasone 2 days matching placebo addition standard care treatment coprimary outcomes proportion children clinically stable 48 hours randomisation proportion children caprelated readmission within 28 days randomisation secondary outcomes include length hospital stay time away routine childcare healthcare utilisation total antibiotic prescriptions within 28 days randomisationeach coprimary outcomes analysed separately test clinical stability rates using proportion test test noninferiority readmission rates construct 1 ci estimated difference test contains predefined margin 7 success conditional tests simulationbased sample size estimation determined recruiting 700 patients ensure power 80 study trial protocol materials approved ethics committees switzerland lead ethikkommission nordwest und zentralschweiz regulatory authority swissmedic participants caregivers provide informed consent prior study procedures commencing trial results published peerreviewed journals national international conferences key messages also disseminated via press social media appropriate nct03474991 snctp000002864