Mary A. Dolansky|Misty A.W. Hawkins|Julie T. Schaefer|Abdus Sattar|John Gunstad|Joseph D. Redle|Richard Josephson|Shirley Moore|Joel W. Hughes
Association Between Poorer Cognitive Function and Reduced Objectively Monitored Medication Adherence in Patients With Heart Failure
Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University|Summa Health System|Case Western Reserve University|Oklahoma State University|Kent State University
background subclinical cognitive impairment prevalent heart failure hf however role important clinical outcomes hf treatment adherence unclear given complex polypharmacy hf treatment cognitive deficits may important predicting medication management thus objective current study examine impact cognitive function medication adherence among communitydwelling patients hf using objective assessments methods results prospective observational cohort design 309 communitydwelling patients hf 597 male 68797 years history dementia neurological disease cognition assessed using neuropsychological battery baseline medication adherence objectively measured 21 days using electronic pillbox regression analyses tested whether attention executive function memory predicted 21day medication adherence unadjusted analyses lower scores 3 cognitive domains predicted poorer medication adherence 05285 p 00010009 adjusting demographic clinical psychosocial variables memory continued predict medication adherence 051 p 0008 whereas executive function 024 p 0075 attention longer predictor 034 p 0131 conclusions poorer cognitive function especially regard memory predicted reduced medication adherence among patients hf history dementia effect remained adjustment factors known predict adherence depressed mood social support disease severity level future studies examine link cognitive impairment medication nonadherence clinical outcomes eg hospitalization mortality clinical trial registration url httpwwwclinicaltrialsgov unique identifier nct01461629