Thorsten Hansen, Bevil R Conway
The color of fruits in photographs and still life paintings
Journal of vision
nomegestrol acetate nomac synthetic potent progestogen study aimed assess risk intracranial meningioma associated prolonged use nomac observational cohort study using snds data france women included one dispensing nomac 2007 2017 dispensing 2006 exposure defined cumulative dose 150 mg nomac within six months first dispensing control group women cumulative dose 150 mg assembled outcome surgery resection decompression radiotherapy one intracranial meningiomas poisson models assessed relative risk rr meningioma total 1060779 women included cohort 535115 exposed group 525664 control group incidence meningioma two groups 193 70 per 100000 personyears respectively ageadjusted rra 29 2437 rra cumulative dose 6 g nomac 120 99160 event treatment discontinuation least one year risk meningioma identical control group rra 10 0813 location meningiomas anterior middle part skull base frequent exposure nomac observed strong dosedependent association prolonged use nomac risk intracranial meningiomas results comparable obtained cyproterone acetate although magnitude risk lower recommended stop using nomac meningioma diagnosed french national health insurance fund cnam french national agency medicines health products safety ansm via health product epidemiology scientific interest group epiphare