Walter Palmas|Thomas G. Pickering|Jeanne Teresi|Joseph E. Schwartz|Andrew E. Moran|Ruth S. Weinstock|Steven Shea
Ambulatory Blood Pressure Monitoring and All-Cause Mortality in Elderly People With Diabetes Mellitus
Columbia University|Hebrew Home|Columbia University|Hebrew Home|Columbia University|Hebrew Home|Columbia University|Hebrew Home|Columbia University|Hebrew Home|Columbia University|Hebrew Home|Columbia University|Hebrew Home
multiethnic cohort older people diabetes n1178 assessed whether ambulatory blood pressure bp monitoring improves prediction allcause mortality cardiovascular mortality added baseline covariates including office bp heart rate hr secondary analyses assessed whether albuminuria may mediate association pulse pressure mortality ambulatory arterial stiffness index calculated 1slope withinperson regression diastoliconsystolic ambulatory bp readings mean followup 6604 years 287 deaths death certificates available 215 deaths 75 110 deemed cardiovascular cause cox models built incrementally first models using clinical laboratory variables selected albuminuria office hrs independent predictors allcause cardiovascular mortality ambulatory monitoring data added sleepwake hr ratio ambulatory arterial stiffness index added significantly prediction allcause mortality sleepwake hr ratio added prediction cardiovascular mortality office hr albuminuria retained significance predictors types mortality secondary analyses without adjustment albuminuria confirmed predictive value office hr sleepwake hr whereas 24hour pulse pressure sleep systolic bp also independently predictive allcause cardiovascular mortality respectively conclusion office hr albuminuria strong predictors mortality ambulatory monitoring improved prediction risk assessment sleep hr dipping ambulatory arterial stiffness index measure dynamic relationship systolic diastolic bps albuminuria may mediate association bp mortality