Clara Martínez-Cao, Ainoa García-Fernández, Leticia González-Blanco, Pilar A Sáiz, Julio Bobes, María Paz García-Portilla
Anticholinergic load: A commonly neglected and preventable risk to cognition during schizophrenia treatment?
Schizophrenia research. Cognition
decision making regarding adjuvant therapy highrisk endometrial cancer complex aim study determine patients clinicians minimally desired survival benefit choose chemoradiotherapy radiotherapy alone moreover influencing factors importance positive negative treatment effects ie attribute investigated patients highrisk endometrial cancer treated adjuvant pelvic radiotherapy without chemotherapy multidisciplinary gynaecologic oncology clinicians completed tradeoff questionnaire based portec3 trial data total 171 patients 63 clinicians completed questionnaire median minimally desired benefit make chemoradiotherapy worthwhile significantly higher patients versus clinicians 10 vs 5 p 002 patients clinicians rated survival benefit important decision making followed longterm symptoms older patients 092 95ci 087097 p 0003 comorbidity 034 95 ci 012089 p 0035 lower preference chemoradiotherapy patients better numeracy skills 12 95ci 105136 p 0011 chemoradiotherapy history 250 95ci 88917 p 0001 higher preference chemoradiotherapy considerable difference minimally desired survival benefit chemoradiotherapy highrisk endometrial cancer among patients clinicians overall endometrial cancer patients needed higher benefits clinicians preferring chemoradiotherapy