Mohamed Elbadry, Fathiya El-Raey, Mohamed Alboraie, Mohamed Abdel-Samiee, Doaa Abdeltawab, Mohammed Hussien Ahmed, Ahmed F Sherief, Ahmed Eliwa, Mina Tharwat, Amira Abdelmawgod, Ossama Ashraf Ahmed, Eman Abdelsameea, Aya Mahros, Abdelmajeed M Moussa, Alshaimaa Eid, Khaled Raafat, Ahmed Yousef, Saad A S Rafea, Youssef Alazzaq, Mohamed Mare'y, Ahmed Abdelaziz, El Sayed Abouzid Ibrahim, Waleed A Abd El Dayem, Ahmed A Abdelmoati, Ahmed Tawheed, Mohammad Amer, Samy Zaky, Mohamed El-Kassas
Clinical and endoscopic characteristics of patients undergoing gastrointestinal endoscopic procedures in Egypt: a nationwide multicenter study
BMC gastroenterology
current classification acute kidney injury aki critically ill patients sepsis relies severitymeasured maximum creatinine overlooks inherent complexities longitudinal evaluation heterogenous syndrome role classification aki based early creatinine trajectories unclear retrospective study identified patients sepsis3 developed aki within 48h intensive care unit admission using medical information mart intensive careiv database used latent class mixed modelling identify early creatinine trajectorybased classes aki critically ill patients sepsis primary outcome development acute kidney disease akd secondary outcomes composite akd allcause inhospital mortality day 7 akd allcause inhospital mortality hospital discharge used multivariable regression assess impact creatinine trajectorybased classification outcomes eicu database external validation among 4197 patients aki critically ill patients sepsis identified eight creatinine trajectorybased classes distinct characteristics compared class transient aki class showed severe aki mild improvement persistence highest adjusted risks developing akd 516 95 ci 287924 composite 7day outcome hr 451 95 ci 269756 class demonstrated late mild aki persistence worsening highest risks developing composite hospital discharge outcome hr 204 95 ci 141294 associations similar external validation 8 classes aki critically ill patients sepsis stratified early creatinine trajectories good predictors key outcomes patients aki critically ill patients sepsis independent aki staging