Svetlana V Doubova|Hortensia Reyes?Morales|Laura del Pilar Torres?Arreola|Magdalena Suárez-Ortega
Potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City
Mexican Social Security Institute|Mexican Social Security Institute|Mexican Social Security Institute|Mexican Social Security Institute
mexico inappropriate prescription drugs potential interactions causing serious risks patient health little studied work area focused mainly hospitalized patients specific drug combinations analyzed moreover studies produced conclusive results present study determined frequency potential drugdrug drugdisease interactions prescriptions ambulatory patients 50 years age used mexican institute social security imss family medicine clinics addition aimed identify associated factors interactionswe collected information general patient characteristics medical histories medication complete data study included 624 ambulatory patients 50 years age nonmalignant pain syndrome made ambulatory visits two imss family medicine clinics mexico city patients received 7day prescriptions nonopioid analgesics potential interactions identified using thompson micromedex program data analyzed using descriptive bivariate multiple logistic regression analysesthe average number prescribed drugs 59 25 800 patients prescriptions implying one potential drugdrug interactions 38 patients prescribed drug combinations interactions avoided also 640 patients prescriptions implying one potential drug disease interactions factors significantly associated one potential interactions included taking 5 medicines adjusted odds ratio 434 95ci 276683 patient age 60 years older adjusted 166 95 ci 101274 suffering cardiovascular diseases adjusted 726 95 ci 4611144the high frequency prescription drugs potential drug interactions showed study suggests common practice primary care level lower frequency potential interactions could necessary make careful selection therapeutic alternatives cases without options patients continuously monitored identify adverse events