Kristine Yaffe|Karla Lindquist|Saunak Sen|Jane A. Cauley|Robert E. Ferrell|Brenda W. J. H. Penninx|Tamara B. Harris|Rongling Li|Steven R. Cummings
Estrogen receptor genotype and risk of cognitive impairment in elders: Findings from the Health ABC study
University of California, San Francisco
determine whether variants estrogen receptors 1 alpha 2 beta esr1 esr2 genes associated cognitive impairment nondemented elderly men womenseveral single nucleotide polymorphisms snps esr1 esr2 genes associated range hormone sensitive diseases breast cancer osteoporosis genetic variations esr may also influence cognitive aging less studied especially among menwe studied 2527 participants enrolled ongoing prospective study communitydwelling elders four snps esr1 four esr2 analyzed measured cognitive function modified minimental status examination 3ms baseline biannually cognitive impairment defined decline five points 4 years calculated odds developing cognitive impairment across snps using genderstratified logistic regression adjusted analyses age education baseline 3ms score addition raceone thousand three hundred fortythree women mean age 734 1184 men mean age 737 comprised cohort among women multivariate adjustment two esr1 snps rs8179176 rs9340799 two esr2 snps rs1256065 rs1256030 associated likelihood developing cognitive impairment although association rs8179176 trend level significance men one esr1 snps rs728524 two esr2 rs1255998 rs1256030 associated cognitive impairment adjustment race attenuated results somewhat association esr snp level bioavailable estradiol testosterone level vary among two snps p005we found among nondemented community elders several snps esr1 esr2 genes associated risk developing cognitive impairment findings suggest estrogen receptor genetic variants may play role cognitive aging