Jinping Xu, Cathryn H Bock, James Janisse, Justin Woo, Michael L Cher, Kevin Ginsburg, Rami Yacoub, Michael Goodman
Determinants of active surveillance uptake in a diverse population-based cohort of men with low-risk prostate cancer: The Treatment Options in Prostate Cancer Study (TOPCS)
Cancer
bradykinesia rigidity considered closely related motor signs parkinson disease pd recent neurophysiological findings suggest distinct pathophysiological mechanisms study aims examine compare longitudinal changes bradykinesia rigidity pd patients treated bilateral subthalamic nucleus deep brain stimulation stndbs retrospective cohort study clinical progression appendicular axial bradykinesia rigidity assessed 15 years stndbs best treatment conditions medication stimulation severity bradykinesia rigidity examined using ad hoc composite scores specific subitems unified parkinsons disease rating scale motor part updrsiii short longterm predictors bradykinesia rigidity analyzed linear regression analysis considering various preoperative demographic clinical data including disease duration severity phenotype motor cognitive scores eg frontal score medication total 301 patients examined 1 year surgery among 101 56 individuals also evaluated 10year 15year followups respectively bradykinesia significantly worsened surgery especially appendicular segments p 0001 conversely rigidity showed sustained benefit unchanged clinical scores compared preoperative assessment p 005 preoperative motor disability eg composite scores updrsiii predicted short longterm outcomes bradykinesia rigidity p 001 executive dysfunction specifically linked bradykinesia rigidity p 005 bradykinesia rigidity show longterm divergent progression pd following stndbs associated independent clinical factors supporting hypothesis partially distinct pathophysiology ann neurol 2024