Sebastian J. Crutch|Manja Lehmann|Jason D. Warren|Jonathan D. Rohrer
The language profile of posterior cortical atrophy
UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London|UK Dementia Research Institute|University College London
h3backgroundh3 posterior cortical atrophy pca typically considered visual syndrome primarily characterised progressive impairment visuoperceptual visuospatial skills however patients commonly describe early difficulties word retrieval paper details first systematic analysis linguistic function pca characterising quantifying aphasia associated pca important clarifying diagnostic selection criteria clinical research studies h3methodsh3 15 patients pca seven patients logopenicphonological aphasia lpa 18 age matched healthy participants completed detailed battery linguistic tests evaluating auditory input processing repetition working memory lexical grammatical comprehension single word retrieval fluency spontaneous speech h3resultsh3 relative healthy controls pca patients exhibited language impairments across domains examined anomia reduced phonemic fluency slowed speech rate prominent deficits pca performance closely resembled lpa patients tests auditory input processing repetition digit span relatively stronger tasks comprehension spontaneous speech h3conclusionsh3 study demonstrates addition well reported degradation vision literacy numeracy pca characterised progressive oral language dysfunction prominent word retrieval difficulties overlap linguistic profiles pca lpa commonly caused alzheimer9s disease emphasises notion phenotypic continuum typical atypical manifestations disease clarifying boundaries alzheimer9s disease phenotypes important implications diagnosis clinical trial recruitment investigations biological factors driving phenotypic heterogeneity alzheimer9s disease rehabilitation strategies ameliorate phonological deficit pca required