Albert Liu|David V. Glidden|Peter L. Anderson|K. Rivet Amico|Vanessa McMahan|Megha Mehrotra|Javier R. Lama|John D. MacRae|Juan Hinojosa|Orlando Montoya|Valdiléa G. Veloso|Mauro Schechter|Esper G. Kallas|Suwat Chariyalerstak|Linda?Gail Bekker|Kenneth R. Mayer|Susan Buchbinder|Robert M. Grant
Patterns and Correlates of PrEP Drug Detection Among MSM and Transgender Women in the Global iPrEx Study
San Francisco Department of Public Health|University of California, San Francisco|University of Colorado Anschutz Medical Campus|University of Colorado Denver|University of Michigan–Ann Arbor|Gladstone Institutes|Gladstone Institutes|Asociación Civil Impacta Salud y Educación|EsSALUD|Asociación para la Conservación de la Cuenca Amazónica|Instituto Ecuatoriano de Enfermedades Digestivas|Instituto Evandro Chagas|Fundação Oswaldo Cruz|Universidade Federal do Estado do Rio de Janeiro|Universidade Federal do Rio de Janeiro|Universidade de São Paulo|Chiang Mai University|Desmond Tutu HIV Foundation|University of Cape Town|Fenway Health|Beth Israel Deaconess Medical Center|University of California, San Francisco|San Francisco Department of Public Health|Gladstone Institutes
background adherence preexposure prophylaxis prep critical efficacy antiretroviral concentrations objective measure prep use correlate efficacy understanding patterns correlates drug detection identify populations risk nonadherence inform design prep adherence interventions methods blood antiretroviral concentrations assessed among active arm participants iprex randomized placebocontrolled trial emtricitabinetenofovir men sex men transgender women 6 countries evaluated rates correlates drug detection among random sample 470 participants week 8 longitudinal cohort 303 participants 72 weeks followup results overall 55 participants 95 confidence interval 49 60 tested week 8 drug detected drug detection associated older age varied study site longitudinal analysis 31 never drug detected 30 always drug detected 39 inconsistent pattern overall detection rates declined time drug detection visits associated older age indices sexual risk including condomless receptive anal sex responding dont know question belief prep efficacy 010 scale conclusions distinct patterns study product use identified significant proportion demonstrating drug detection visit research literacy may explain greater drug detection among populations greater research experience older men sex men united states greater drug detection among reporting highest risk sexual practices expected increase impact costeffectiveness prep