Deborah L. Harris|Jane Alsweiler|Juliet Ansell|Gregory D. Gamble|Benjamin Thompson|Trecia Wouldes|Tzu-Ying Yu|Jane E Harding|Juliet Ansell|Coila Bevan|Jessica Brosnanhan|Ellen Campbell|Tineke J Crawford|Kelly Fredell|Karen Frost|Greg Gamble|Anna C. Gsell|Claire Hahnhaussen|Safayet Hossin|Yannan Jiang|Kelly Jones|Sapphire Martin|Christopher J. D. McKinlay|G. Tipton McKnight|Christina McQuoid|John Paynter|Jenny Rogers|Kate Sommers|Heather Stewart|Anna Timmings|Jessica Wilson|R. T. Young|Nicola Anstice|Joshua Arthur|Scott P. Bruder|Arijit Chakraborty|Robert J. Jacobs|Gordon O. Matheson|Nabin Paudel|Tzu-Ying Yu|Matthew Signal|Aaron Le Compte|Max Berry|Arun Nair|Ailsa Tuck|Alexandra Wallace|Phil J Weston|Jane Alsweiler|Jane E Harding|Benjamin Thompson|Trecia Wouldes|J. Geoffrey Chase|Deborah L. Harris|Heidi M. Feldman|Darrell Wilson|William W. Hay|Robert M. Hess
Outcome at 2 Years after Dextrose Gel Treatment for Neonatal Hypoglycemia: Follow-Up of a Randomized Trial
Waikato District Health Board|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|University of Auckland|Waikato District Health Board|University of Auckland
objective determine neurodevelopmental outcome 2 years corrected age children randomized treatment dextrose gel placebo hypoglycemia soon birth sugar babies study study design followup study 184 children hypoglycemia 26 mm 47 mgdl first 48 hours randomized either dextrose 90118 76 placebo gel 94119 79 assessments performed kahikatea house hamilton new zealand included neurologic function general health pediatrician assessed cognitive language behavior motor skills bayley scales infant toddler development third edition executive function clinical assessment behaviour rating inventory executive functionpreschool edition vision clinical examination global motion perception coprimary outcomes neurosensory impairment cognitive language motor score 1 sd cerebral palsy blind deaf processing difficulty executive function global motion perception worse 15 sd mean statistical tests two sided 5 significance level results mean sd birth weight 3093 803 g mean gestation 377 16 weeks sixtysix children 36 neurosensory impairment 1 severe 6 moderate 59 mild similar rates groups dextrose 38 vs placebo 34 relative risk 111 95 ci 075163 processing difficulty also similar groups dextrose 10 vs placebo 18 relative risk 052 95 ci 023115 conclusions dextrose gel safe treatment neonatal hypoglycemia neurosensory impairment common among children trial registration australian new zealand clinical trials registry actrn 12608000623392 determine neurodevelopmental outcome 2 years corrected age children randomized treatment dextrose gel placebo hypoglycemia soon birth sugar babies study followup study 184 children hypoglycemia 26 mm 47 mgdl first 48 hours randomized either dextrose 90118 76 placebo gel 94119 79 assessments performed kahikatea house hamilton new zealand included neurologic function general health pediatrician assessed cognitive language behavior motor skills bayley scales infant toddler development third edition executive function clinical assessment behaviour rating inventory executive functionpreschool edition vision clinical examination global motion perception coprimary outcomes neurosensory impairment cognitive language motor score 1 sd cerebral palsy blind deaf processing difficulty executive function global motion perception worse 15 sd mean statistical tests two sided 5 significance level mean sd birth weight 3093 803 g mean gestation 377 16 weeks sixtysix children 36 neurosensory impairment 1 severe 6 moderate 59 mild similar rates groups dextrose 38 vs placebo 34 relative risk 111 95 ci 075163 processing difficulty also similar groups dextrose 10 vs placebo 18 relative risk 052 95 ci 023115 dextrose gel safe treatment neonatal hypoglycemia neurosensory impairment common among children