Guiliana Mas, Tania Tello, Pedro Ortiz, Dafina Petrova, Rocío García-Retamero
[Graphical and numerical skills in pre- and postgraduate medical students from a private university]
Gaceta medica de Mexico
manganese lipoxygenase mnlox enzyme converts polyunsaturated fatty acids alkyl hydroperoxides proposed mechanisms enzyme transfer hydrogen atom substrate ch bond activesite mniiihydroxo center initiates substrate oxidation proposed mechanisms activesite mniiihydroxo complex regenerated reaction mniiialkylperoxo intermediate water ligand substitution reaction recent study described pair mniiihydroxo mniiialkylperoxo complexes supported amidecontaining pentadentate ligand 6medpaq present work describe reaction mniiihydroxo unit ch oh bond oxidation processes thus mimicking one elementary reactions mnlox enzyme analysis kinetic data shows mniiihydroxo complex mniiioh6medpaq oxidizes tempoh 2266tetramethylpiperidine1ol faster majority previously reported mniiihydroxo complexes using combination cyclic voltammetry electronic structure computations demonstrate weak mniiinpyridine bonds lead higher mniiiii reduction potential increasing driving force substrate oxidation reactions accounting faster reaction rate addition demonstrate mniiialkylperoxo complex mniiiootbu6medpaq reacts water obtain corresponding mniiihydroxo species thus mimicking ligand substitution step proposed mnlox