Hassan Hashemi, Mohammad Saatchi, Mehdi Khabazkhoob, Mohammad Hassan Emamian, Abbasali Yekta, Akbar Fotouhi
Distribution of keratometry and its determinants in a general population of 6- to 12-year-old children
European journal of ophthalmology
science technology evolved quickly two decades 21st century healthcare systems grounded last centurys structure processes changes way health care provided demanded digital transformation key driver making healthcare systems accessible agile efficient citizencentered nevertheless way healthcare systems function challenges development innovation development regulatory requirements assessment methodological guidance weaknesses adoption digital applications das wtswrng ww innovative da uses images interact citizens symptom triage monitoring used example show challenges faced development clinical validation overcome prove wws value inception novel approaches evidence generation allows agile patientcentered development applied early scientific advice nice uk sought study design iterative development interim analysis performed different statistical parameters kappa b statistic explored face development assessment challenges ww triage accuracy cutoff time ranged 062 094 frequent symptoms attending emergency department ed observed concordance 12 frequent diagnostics hospital discharge fluctuating 04 097 8 diagnostics concordance greater 08 experience provoke reflective thinking da developers digital health scientists regulators health technology assessors payers