Kelong Zhong, Xuemei An, Yun Kong
The effectiveness of five-element music therapy for post-stroke depression: A systematic review and meta-analysis
Heliyon
mutyh associated polyposis map autosomal recessive disorder inheritance constitutional biallelic pathogenic mutyh variants predisposes person development adenomas colorectal cancer crc also associated extracolonic extraintestinal manifestations may overlap phenotype familial adenomatous polyposis fap currently discrepancies literature regarding whether certain phenotypes truly associated map narrative review aims explore phenotypic spectrum map better characterise map phenotype literature search conducted identify articles reporting mapspecific phenotypes clinical data 2109 map patients identified literature showed 1123 patients 532 crc patients crc associated adenomas suggesting adenomas obligatory component map carriers two missense founder variants possibly truncating variants increased cancer risk compared carry pathogenic variants suggested somatic gcta transversions mutational signature map could used biomarker screening identifying patients atypical map associating certain phenotypes map extracolonic extraintestinal manifestations associated map include duodenal adenomas duodenal cancer fundic gland polyps gastric cancer ovarian cancer bladder cancer skin cancer association breast cancer endometrial cancer map remains disputed desmoids congenital hypertrophy retinal pigment epithelium chrpes rarely reported map long seen fap patients thus could act distinguishing feature two collection map phenotypes assist assessment pathogenic mutyh variants using american college medical genetics association molecular pathology acmgamp variant interpretation guidelines ultimately improve patient care