Bo Fang, Jing Wei, Lei Chen, Shan Jin, Qi Li, Renzhi Cai, Naisi Qian, Zhen Gu, Lei Chen, Romain Santon, Chunfang Wang, Weimin Song
Short-term association of particulate matter and cardiovascular disease mortality in Shanghai, China between 2003 and 2020
Frontiers in public health
background fetal exposure paracetamol acetaminophen shown associated asthma atopic disorders well behavioural problems including hyperactivity childhood however little information scholastic abilities among children exposed paracetamol pregnancy objectives determine whether differences scholastic abilities among offspring women ingested paracetamol pregnancy compared nonexposed children methods mothers enrolled avon longitudinal study parents children alspac recorded frequency taken medication two time periods pregnancy first 18 weeks ii 1832 weeks offspring followed ever since study use outcomes 14 tests ability reading 2 spelling using studys tests national education system test results b 6 mathematical abilities including tests arithmetic mathematical reasoning c 1 scientific understanding multiple regression used adjusting 15 different exposures including reasons taking medication well demographic features results almost unadjusted adjusted mean differences negative ie exposed maternal intake paracetamol less well negative associations exposures 18 32 weeks gestation much evident exposures earlier pregnancy later exposures adjustment 12 23 scholastic tests associated prenatal exposure paracetamol p 005 negative effects found girls 12 tests p 005 boys 0 tests p 005 conclusion evidence longitudinal study suggests maternal exposure paracetamol associated disadvantages offspring scholastic abilities mathematics reading secondary school ages raises question whether longerlasting effects educational attainment age 15 years onwards including university level clearly results tested settings meanwhile add growing accumulation known adverse effects exposure paracetamol pregnancy