Heemoon Lim, Hyejung Lee
Eating Habits and Lifestyle Factors Related to Childhood Obesity Among Children Aged 5-6 Years: Cluster Analysis of Panel Survey Data in Korea
JMIR public health and surveillance
hand osteoarthritis poses significant health challenge globally due increasing prevalence substantial burden individuals society current clinical practice treatment options hand osteoarthritis encompass range approaches including biological agents antimetabolic drugs neuromuscular blockers antiinflammatory drugs hormone medications pain relievers new synergistic drugs medications despite diverse array treatments determining optimal regimen remains elusive study seeks conduct network metaanalysis assess effectiveness safety various drug intervention measures treatment hand osteoarthritis findings aim provide evidencebased support clinical management hand osteoarthritis performed comprehensive search across pubmed embase web science cochrane central register controlled trials conducted september 15th 2022 identify relevant randomized controlled trials meticulous screening data extraction cochrane handbooks risk bias assessment tool applied evaluate study quality data synthesis carried using stata 151 software 21 studies data 3965 patients metaanalyzed involving 20 distinct western medicine agents gcsb5 specific herbal complex mainly regulate pain hand osteoarthritis showed greatest reduction pain wmd 1300 95 ci 2669 069 crx102 specific medication characterized significant effect relieving joint stiffness symptoms remarkably mitigated stiffness wmd 750 95 ci 890 610 chondroitin sulfate displayed highest incidence adverse events rr 026 95 ci 006 122 substantial variation functional index hand osteoarthritis score improvement identified distinct agents placebo summary gcsb5 crx102 exhibit efficacy alleviating pain stiffness hoa respectively however cautious interpretation results advised tailored treatment decisions based individual contexts imperative