Hae Won Kim
Awareness of human papillomavirus and factors associated with intention to obtain HPV vaccination among Korean youth: quasi experimental study
BMC international health and human rights
review powerful new algorithms build intuitive biological interpretation techniques statistical analysis functional genomics experiments although originally designed transcriptomics argue algorithms applicable type omics study transcriptomics proteomics metabolomics rank products rp strictly nonparametric test statistic detect differentially regulated elements genes proteins metabolites genomewide screens rp particularly powerful noisy data low numbers replicates makes full use availability large number parallel measurements typical modern largescale experiments iterative group analysis iga statistical method makes transition regulated single elements significant classes elements thus provides automatic functional annotation experiment graphbased iga giga extension iga combines experimental data broad variety biological annotations highlight physiologically relevant regions given evidence graph eg metabolic networks signaling pathway diagrams protein interaction maps sequential application techniques yields increasingly abstract interpretation experimental data time quantitative statistically rigorous biologically significant results used either helpful tools guide data visualization exploration input downstream computational applications systems biology framework