Lena Jafri, Arsala Jameel Farooqui, Janet Grant, Usmaan Omer, Rodney Gale, Sibtain Ahmed, Aysha Habib Khan, Imran Siddiqui, Farooq Ghani, Hafsa Majid
Insights from semi-structured interviews on integrating artificial intelligence in clinical chemistry laboratory practices
BMC medical education
human nonhuman primate data clearly implicate dorsolateral prefrontal cortex dlpfc critical advanced cognitive functions 12 thought intracortical synaptic architectures within dlpfc integral neurobiological substrate gives rise processes including working memory inferential reasoning decisionmaking 37 prevailing model cortical column makes one fundamental processing unit composed dense intrinsic connectivity conceptualized canonical cortical microcircuit 38 cortical microcircuit receives sensory cognitive information variety sources represented sustained activity within microcircuit referred persistent recurrent activity 49 via recurrent connections within microcircuit activity propagate variable length time thereby allowing temporary storage computations occur locally ultimately passing transformed representation downstream output 4510 competing theories regarding microcircuit activity coordinated proven difficult reconcile vivo intercortical intracortical computations cannot fully dissociated 591112 interrogated intrinsic features isolated microcircuit networks using highdensity calcium imaging macaque dlpfc ex vivo found spontaneous activity intrinsically maintained microcircuit architecture persisting high rate absence extrinsic connections using perisulcal stimulation evoke persistent activity deep layers found activity propagates stochastically assembled intracortical networks creating predictable populationlevel events largely nonoverlapping ensembles microcircuit excitability covaried individual cognitive performance thus anchoring heuristic models abstract cortical functions within quantifiable constraints imposed underlying synaptic architecture