Chien Hsiun Chen|Toshiki Mizuno|Robert C. Elston|Monica M. Kariuki|Kathleen Hall|Fred Unverzagt|Hugh C. Hendrie|S. Gatere|Paul Kioy|Nilesh B. Patel|Robert P. Friedland|Raj N. Kalaria
A comparative study to screen dementia and APOE genotypes in an ageing East African population
Case Western Reserve University
previous studies established crosscultural methods screen ageing related dementia susceptibility genes particular alzheimers disease ad among canadian cree african americans yoruba nigeria determined whether community screening interview dementia csid translated kikuyu major language kenya could used evaluate dementia alzheimer type using two sets coefficients cognitive informant scores two discriminant function df scores calculated 100 elderly 65 years nyeri kenyans cutoff points selected 100 sensitivities specificities df scores remarkably similar 9375 kenyan sample propose adapted csid utilised detect dementia among east africans also show apolipoprotein e epsilon 4 allele frequencies high approximately 30 different normal subjects probable ad evidence suggest years education vascular factors associated dementia status