Francisco Hernandez, Michael Macaluso
Read like a man: comparing narratives of masculinity in adolescent literature
Frontiers in sociology
antifungal medications important due potential application cancer treatment either traditional treatments mechanisms prevent effects medications restrict usage cancer treatment completely understood evaluation discrimination possible protective effects antiapoptotic members bcl2 family proteins critical regulators mitochondrial apoptosis antifungal druginduced cell death still scientific uncertainties must considered novel simple reliable strategies highly demanded identify biochemical signature phenomenon however complex nature cells poses challenges analysis cellular biochemical changes classification study first time investigated probable protective activities bcl2 mcl1 proteins cell damage induced ketoconazole ket fluconazole flu antifungal drugs yeast model surfaceenhanced raman spectroscopy sers approach proposed sers platform created robust raman spectra high signaltonoise ratio analysis sers spectral data via advanced unsupervised supervised machine learning methods enabled unquestionable differentiation 100 samples biomolecular identification various sers bands related lipids proteins observed analyses suggest expression antiapoptotic proteins reduces oxidative biomolecule damage induced antifungals also cell viability assay annexin vfitcpi double staining total oxidant antioxidant status analyses performed support raman measurements strongly believe proposed approach paves way evaluation various biochemical structureschanges various cells