Felicia Zhang, Jia Ren, Colin Garon, Zhuoying Huang, John Kubale, Abram L Wagner
Complex interplay of science reasoning and vaccine hesitancy among parents in Shanghai, China
BMC public health
aspergillus fumigatus fumigatus emerged significant pathogen patients cystic fibrosis cf currently within top five isolated organisms reported several international cf patient registries fumigatus attributed disease progression although role remains controversial paucity reports infection dynamics aim study examine time first laboratory reports fumigatus acquisition correlate patient gender cystic fibrosis transmembrane conductance regulator cftr mutation type one hundred adult 18 years cf patients examined 50 females 50 males mean age 246 years 625 sd median age 24 years maximum age 76 years cftr mutation groups consisted f508delf508del homozygous n 45 ii f508delother heterozygous n 45 iii others n 10 cftr mutation type patient gender presenceabsence fumigatus time months first isolation fumigatus examined microbiological data examined 100 patients birth present 31122021 equating 2455 patient years fumigatus isolated 66100 66 adult cf patients f508delf508del homozygous 82 3745 ii f508delother heterozygous 56 2545 iii others 40 410 within f508delother heterozygous group 14 mutations noted second allele r560t r117h collectively accounting 36 second mutations four unique alleleallele mutations noted mutations category trend higher fumigatus acquisition f508delf508del homozygous patients f508delother patients p 00529 66 patients positive fumigatus 3553 male 3147 female median mean time first isolation fumigatus fumigatuspositive patients 1195 months 128 months respectively shortest time 12 months longest time 288 months statistical significance timetofirst isolation relation cftr mutation group p 00272 whereby f508del homozygous individuals first isolation fumigatus 1168 79 months mean standard error mean sem f508del heterozygous patients first isolate fumigatus 1504 months 137 months mean sem approximately 275 years f508del homozygous peers significant difference p 012 time first acquisiton males females whereby males first fumigatus isolate 118 94 months whereas females first fumigatus isolate 140 108 months highest rate first fumigatus isolation 4 years 16 years age 16 years approximately 85 fumigatuspositive patients recorded first fumigatus isolate minimise risk first acquisition fumigatus important infection prevention educational messaging delivered paediatric clinic enhance health literacy around fumigatus acquisition