Petros Isaakidis|Marie?Eve Raguenaud|Vantha Te|Chhraing S. Tray|Kazumi Akao|Varun Kumar|Sopheak Ngin|Eric Nerrienet|Rony Zachariah
High survival and treatment success sustained after two and three years of first?line ART for children in Cambodia
Ministry of Health|Angkor Hospital for Children|Angkor Hospital for Children|Angkor Hospital for Children|Institut Pasteur du Cambodge|Institut Pasteur du Cambodge|Médecins Sans Frontières
longterm outcomes antiretroviral therapy art children remain poorly documented resourcelimited settings objective study assess twoand threeyear survival cd4 evolution virological response among children art programmatic setting cambodiachildren treated firstline art least 24 months assessed viral load testing genotyping used kaplanmeier analysis survival cox regression identify risk factors associated treatment failureof 1168 registered hivpositive children 670 57 started art january 2003 december 2007 survival probability 093 95 ci 091095 091 95 ci 088093 24 36 months art initiation respectively median cd4 gain children aged five years 704 cellsmm3 24 months 737 36 months median cd4 percentage gain children five years old 152 24 months 15 36 months one hundred thirty children completed least 24 months art 138 completed 36 months 128 268 48 female median age art initiation six yearsoverall 22 children viral loads 1000 copiesml success ratio 86 intentiontotreatanalysis 21 21 presented mutations conferring resistance mostly lamivudine nonnucleoside reverse transcriptase inhibitors risk factors failure 24 36 months cd4 counts threshold severe immunosupression months respectively two 22 children viral loads 1000 copiesml met world health organization immunological criteria failure sensitivity 01good survival immunological restoration viral suppression sustained two three years art among children resourceconstrained settings increased access routine virological measurements needed timely diagnosis treatment failure