Nicole Marinsek, Benjamin O Turner, Michael Gazzaniga, Michael B Miller
Divergent hemispheric reasoning strategies: reducing uncertainty versus resolving inconsistency
Frontiers in human neuroscience
patients intrahepatic cholangiocarcinoma managed targeted therapies directed specific molecular alterations consequently tissue samples submitted pathology department must produce molecular information addition diagnosis resection specimens staging information pathologists role evaluating specimens therefore changed accommodate personalised approaches developed recommendations guidance pathologists conducting systematic review existing guidance generate candidate statements followed international delphi process fiftynine pathologists 28 countries six continents rated statements mapped elements specimen pathway receipt pathology department authorisation final written report separate survey endusers report including surgeons oncologists gastroenterologists undertaken evaluate information included written report enable appropriate patient management fortyeight statements reached consensus inclusion guidance including 10 statements content written report also reached consensus enduser participants reporting proforma allow easy inclusion recommended data points developed guiding principles recommendations provide framework allow pathologists reporting patients intrahepatic cholangiocarcinoma maximise informational yield specimens required personalised patient management biopsy resection lesional tissue intrahepatic cholangiocarcinoma must yield information molecular abnormalities within tumour define suitability personalised therapies addition diagnosis staging information developed international consensus guidance pathologists report cases using delphi process sought views pathologists endusers pathology reports guide highlights need report cases way preserves tissue molecular testing emphasises reporting requires interpretation histological characteristics within broader clinical radiological context guide allow pathologists report cases intrahepatic cholangiocarcinoma uniform manner maximises value tissue received facilitate optimal multidisciplinary patient management