Gayle Haischer-Rollo, Jamie Lynn Geringer, Katryna Thomas, Diane Hale
Do You See What I See? A Comparison of CCC and Self-Assigned Milestones Across Military Medical Specialties
Journal of surgical education
mortality prediction interstitial lung disease ild poses significant challenge clinicians due heterogeneity across disease subtypes currently forced vital capacity fvc gender age physiology gap score two utilized metrics prognostication recently machine learning classifier system fibresolve designed identify variety computed tomography ct patterns associated idiopathic pulmonary fibrosis ipf demonstrated significant association mortality across multiple subtypes ild purpose followup study retrospectively validate findings large external cohort patients ild multicenter validation study fibresolve applied chest ct scans patients confirmed ild available followup data fibresolve scores categorized tertile analyzed using cox regression analysis adjusted tobacco use modified gap mgap score 643 patients included 446 693 died median followup time 144 1821 weeks median range mgap score 5 37 multivariable analysis fibresolve score categorized tertile significantly associated mortality tertile 2 hr 147 95 ci 082237 p 011 tertile 3 hr 312 95 ci 198490 p 0001 subgroup analyses revealed significant associations amongst nonipf ilds tertile 2 hr 195 95 ci 128297 tertile 3 hr 466 95 ci 294738 severe disease defined fvc 75 tertile 2 hr 229 95 ci 143367 tertile 3 hr 480 95 ci 293786 fibresolve independently associated mortality ild particularly amongst patients nonipf ilds severe disease