Janine R Blakeslee
Effects of high-fidelity simulation on the critical thinking skills of baccalaureate nursing students: A causal-comparative research study
Nurse education today
interindividual variation blood pressure bp arises part sequence variants within enhancers modulating expression causal genes propose genes active tissues relevant bp physiology identified tissuelevel epigenomic data genotypes bpphenotyped individuals used chromatin accessibility data heart adrenal kidney artery identify cisregulatory elements cres tissues estimate impact common human singlenucleotide variants within cres gene expression using machine learning methods identify causal genes performed genewise association test conducted analyses 2 separate largescale cohorts 77 822 individuals genetic epidemiology research adult health aging 315 270 individuals uk biobank identified 309 259 331 367 genes false discovery rate 005 diastolic bp 191 184 204 204 genes systolic bp artery kidney heart adrenal respectively genetic epidemiology research adult health aging 50 70 genes replicated uk biobank significantly higher 12 15 expected chance p00001 results enabled tissue expression prediction 988 2875 putative bp genes individuals cohorts construct expression polygenic score score explained 27 reported singlenucleotide variant heritability substantially higher expected prior studies work demonstrates power tissuerestricted comprehensive cre analysis followed crebased expression prediction understanding bp regulation relevant tissues provides dualmodality supporting evidence cre expression causality genes