Emily A Ogutu, Anna S Ellis, Kyra A Hester, Katie Rodriguez, Zoe Sakas, Chandni Jaishwal, Chenmua Yang, Sameer Dixit, Anindya Sekhar Bose, Moussa Sarr, William Kilembe, Robert Bednarczyk, Matthew C Freeman
Success in vaccination programming through community health workers: a qualitative analysis of interviews and focus group discussions from Nepal, Senegal and Zambia
BMJ open
hand foot mouth disease hfmd common infectious disease children enterovirus a71 eva71 one main pathogens coxsackievirus a6 cva6 gradually become dominant pathogen hfmd recent years study conducted mainly assess serological prevalence eva71 cva6 antibodies people different ages sexes regions systematic review metaanalysis comprehensive study performed based eva71 cva6 serological literature published may 2022 heterogeneity analysis cochranes q test i2 statistic random effect models adopted subgroup metaregression analyses used identify potential sources heterogeneity data analysis performed using stata version 160 study included 71 studies involving 55176 people 13 countries met inclusion criteria serological prevalence eva71 antibody different studies 431888 cva6 antibody 408809 metaanalysis results showed serum positive rate eva71 antibody 459 95 ci 376541 rate chinese population 478 95 ci 424532 countries 38 95 ci 2355 serum positive rate cva6 antibody 583 95 ci 465702 rate chinese population 491 95 ci 383599 countries 68 95 ci 5183 subgroup analysis also conducted seroprevalence eva71 cva6 antibodies related age rather gender region rates eva71 cva6 seropositivity considerably lower children younger five years age however rates gradually increase age findings study suggest children five years age may susceptible eva71 cva6 thus safety education vaccination strengthened accordingly study provides basis understanding risk factors eva71 cva6 infection china deciding formulate standard preventive measures prevent spread virus