Mariette Derwig, Irén Tiberg, Jonas Björk, Inger Hallström
Child-Centred Health Dialogue for primary prevention of obesity in Child Health Services - a feasibility study
Scandinavian journal of public health
access hepatis c treatment subsaharan africa clinical public health ethical concern multicountry openlabel trial tac anrs 12311 allowed assessing feasibility safety efficacy specific care model hcv treatment retreatment patients hepatitis c sub saharan africa november 2015 march 2017 followup mid 2019 treatmentnave patients hcv without decompensated cirrhosis liver cancer recruited receive 12 weektreatment either sofosbuvir ribavirin hcv genotype 2 sofosbuvir ledipasvir genotype 1 4 retreatment sofosbuvir velpatasvir voxilaprevir case virological failure primary outcome sustained virological response 12 weeks end treatment svr12 secondary outcomes included treatment adherence safety svr12 patients retreated due nonresponse firstline treatment model care relied viral load assessment educational sessions increase patient awareness adherence health literacy study recruited 120 participants 36 hivcoinfected 14 cirrhotic one patient discontinued treatment return home country neither death severe adverse event occurred svr12 reached 107 patients 89 90 genotype 1 2 88 gt4 retreated patients n 13 reached svr12 hcv treatment highly acceptable safe effective model care implementation research needed scale pointofcare hcv testing svr assessment along community involvement patient education achieve hcv elimination subsaharan africa