Gabriella Nagy, Ferenc Arató, István G Télessy, Aranka Varga, András Fittler
A Scoping Review of Educator Proficiency Interventions in Pharmacy Education Illustrated by an Interdisciplinary Model Integrating Pedagogical Theories into Practice
Pharmacy (Basel, Switzerland)
comparative studies covariate balance sequential allocation schemes attracted growing academic interest although many theoretically justified adaptive randomization methods achieve covariate balance often allocate patients pairs groups better meet practical requirements clinicians cannot wait participants assign current patient economic ethical reasons propose method randomizes patients individually sequentially proposed method conceptually separates covariate imbalance measured newly proposed modified mahalanobis distance marginal imbalance sample size difference 2 groups minimizes explicit priority order compared existing sequential randomization methods proposed method achieves best possible covariate balance maintaining marginal balance directly offering us control randomization process demonstrate superior performance proposed method wide range simulation studies real data analysis also establish theoretical guarantees proposed method terms convergence imbalance measure subsequent treatment effect estimation