Mirjam Curno|Samuela Rossi|Ioannis Hodges-Mameletzis|Rowena Johnston|Matthew A. Price|Shirin Heidari
A Systematic Review of the Inclusion (or Exclusion) of Women in HIV Research
Médecins Sans Frontières|International AIDS Society|University of Bern|International AIDS Society|International AIDS Society|World Health Organization|American Foundation for AIDS Research|University of California, San Francisco|International AIDS Vaccine Initiative|International AIDS Society
introduction effect clinical interventions differ sexgender studies shown women often underrepresented medical research aim systematic literature review characterize womens participation hiv clinical studies antiretroviral drugs arv prophylactic vaccines vax curative strategies cure methods systematic pubmed searches conducted identify arv vax cure studies data extracted number women date publication sources funding country study trial phase correlates female participation assessed results women represented median 192 participants arv studies 387 381 vax studies 53 111 cure studies 104 funding source correlated proportion female participants vax cure studies arv studies p 003 arv trials funded private noncommercial sources highest proportion women whereas publicly funded trials lowest female participation median 167 median proportion women arv trials fully partially funded national institutes health significantly lower median trials funded sources 196 vs 223 p 0001 conclusions although women comprise nearly half people living hiv continue underrepresented clinical studies despite federal policies established address study shows publicly funded arv trials recruit even fewer women trials urgent need ensure hiv clinical studies consider sexgender dimensions