Andreas Deutsch, Josué Manik Nava-Sedeño, Simon Syga, Haralampos Hatzikirou
BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration
PLoS computational biology
primary neuroendocrine neoplasms breast brnens rare classification updated recent years making interpretation data published challenging unclear whether neuroendocrine differentiation associated poorer prognosis treatment approaches applied database breast cancer patients treated 2009 2022 maria sklodowskacurie national research institute oncology branch krakow explored search brnens patients medical pathological data collected analyzed included 22 females brnen without metastases time diagnosis median age 64 years range 2888 cases 18 hormone receptor positive her2 negative median ki67 27 10100 median tumor size time diagnosis 295mm 775mm 9 patients npositive dcis present 5 cases one case negative chromogranin synaptophysin staining data missing 4 cases nine patients received adjuvant chemotherapy mainly based anthracyclines taxanes 16 received adjuvant hormonal therapy 15 received postoperative radiotherapy radical surgery performed patients two underwent suboptimal tumorectomy one patient local recurrence three experienced metastatic disease involving lungs patients still alive median followup 96 months 8153 two patients died follow time recurrence 4 years results compared twelve case series collecting clinical data brnens median patient number 105 range 3142 brnens represent heterogenous group diseases lacking data prospective studies clinical trials established treatment standards tailored brnens patients cohort exhibited favorable prognosis potentially attributed lower tumor stage ki67 index compared reported case series suggest radical surgery postoperative radiotherapy administered akin standard treatment breast cancer special type esmo also advocates approach systemic treatment although recommend considering platinumbased chemotherapy patients poorly differentiated brnens exhibiting high ki67