Susitha Wanigaratne, Baiju Shah, Therese A Stukel, Hong Lu, Sophia Den Otter-Moore, Janavi Shetty, Natasha Saunders, Sima Gandhi, Astrid Guttmann
COVID-19 hospitalization, mortality and pre-mature mortality by a history of immigration in Ontario, Canada: a population-based cohort study
Lancet regional health. Americas
examine ability physiologically based mathematical model human circadian rhythms predict circadian phase measured salivary dim light melatonin onset dlmo children compared proxy measurements circadian phase bedtime sleep midpoint wake time part ongoing clinical trial sample 29 elementary school children mean age 74 97 years completed 7 days wrist actigraphy lab visit assess dlmo hourly salivary melatonin samples collected dim light conditions 5 lx data actigraphy used generate predictions circadian phase using physiologically based circadian limit cycle oscillator mathematical model hannay model published regression equations utilize average sleep onset midpoint offset predict dlmo agreement proxy predictions measured dlmo assessed compared dlmo predictions using hannay model outperformed dlmo predictions based childrens sleepwake parameters lins concordance correlation coefficient linccc 079 compared 041059 sleepwake parameters mean absolute error 31 min hannay model compared 3538 min sleepwake variables findings suggest sleepwake behaviors weak proxies dlmo phase children mathematical models using data collected wearable data used improve accuracy predictions additional research needed better adapt adult models use children heart rhythm project healthy sleep behavioral rhythms obesity prevention httpsclinicaltrialsgovct2shownct04445740