Tze Ping Loh, Chun Yee Lim, Sunil Kumar Sethi, Rui Zhen Tan, Corey Markus
Advances in internal quality control
Critical reviews in clinical laboratory sciences
given increasingly large number loci discovered psychiatric gwas specification key biological pathways underlying loci become priority field previously leveraged pleiotropic genetic relationships schizophrenia two cognitive phenotypes educational attainment cognitive task performance differentiate two subsets illnessrelevant snps 1 concordant alleles associated reduced cognitive abilityeducation increased schizophrenia risk 2 discordant alleles linked reduced educational andor cognitive levels lower schizophrenia susceptibility present study extend prior work utilizing larger input gwas datasets powerful statistical approach pleiotropic metaanalysis pleiotropic locus exploration interpretation using optimal test pleio pleiotropic metaanalysis schizophrenia two cognitive phenotypes revealed 768 significant loci 159 novel among 347 loci harbored concordant snps 270 encompassed discordant snps 151 dual loci contained concordant discordant snps competitive geneset analysis using magma related concordant snp loci neurodevelopmental pathways eg neurogenesis whereas discordant loci associated mature neuronal synaptic functions distinctions also observed brainspan analysis temporal enrichment patterns across developmental periods concordant loci containing prenatally expressed genes discordant loci dual loci enriched genes related mrna translation initiation representing novel finding schizophrenia literature