The University of Texas Medical Branch at Galveston|The University of Texas Medical Branch at Galveston|The University of Texas Medical Branch at Galveston|The University of Texas Medical Branch at Galveston|The University of Texas Medical Branch at Galveston
objectives examine association frailty status change cognitive function time older mexican americans design data used hispanic established population epidemiological study elderly setting five southwestern states texas new mexico colorado arizona california participants one thousand three hundred seventy noninstitutionalized mexicanamerican men women aged 65 older minimental state examination mmse score 21 higher baseline 199596 measurements frailty defined three following components unintentional weight loss 10 pounds weakness lowest 20 grip strength selfreported exhaustion slow walking speed lowest 20 16foot walk time seconds low physical activity level lowest 20 physical activity scale elderly score information sociodemographic factors mmse score medical conditions stroke heart attack diabetes mellitus arthritis cancer hypertension depressive symptoms visual impairment obtained results 1370 subjects 684 499 frail 626 457 prefrail 12 components 60 44 frail 3 components 199596 using general linear mixed models found frail subjects greater cognitive decline 10 years frail subjects estimate067 standard error013 p lt001 association remained statistically significant controlling potential confounding factors conclusion frail status older mexican americans mmse scores 21 higher baseline independent predictor mmse score decline 10year period future research needed establish pathophysiological components clarify relationship frailty cognitive decline