Milo A. Puhan|Alka Ahuja|Mark L. Van Natta|Lori E. Ackatz|Curtis L. Meinert
Interviewer versus self-administered health-related quality of life questionnaires - Does it matter?
Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Northwestern Medical Faculty Foundation|Johns Hopkins University
patientreported outcomes measured many epidemiologic studies using self intervieweradministered questionnaires studies differences administration formats observed studies show statistically significant differences important patients since evidence effect administration format inconsistent mainly available crosssectional studies aim assess effects different administration formats repeated measurements patientreported outcomes participants aids enrolled longitudinal study ocular complications aidswe included participants enrolled longitudinal study ocular complications aids lsoca completed medical outcome study mos hiv questionnaire euroqol feeling thermometer visual function questionnaire vfq 25 every six months thereafter using self intervieweradministration large print questionnaire available participants visual impairment considering measurements time adjusting patient study site characteristics used linear models compare hrql scores scores 0100 administration formats defined adjusted differences 02 standard deviations sd quantitatively meaningfulwe included 2261 participants 806 males median 431 years age enrollment provided data 23420 study visits selfadministered moshiv feeling thermometer euroqol used 70 visits vfq25 80 eight domains moshiv differences interviewer self administered format 01 sd differences scores highest social role function domains adjusted differences still 02 sd quantitatively meaningful difference administration formats euroqol feeling thermometer vfq25 domain scores ocular pain vfq25 found statistically significant difference 35 95 ci 02 68 however exceed 02 sd instruments scores similar large standard print formats adjusted differences 02 sdour large study provides evidence administration formats meaningful effect repeated measurements patientreported outcomes consequence longitudinal studies may need consider effect different administration formats analyses