Lucie Lerouge, Aurélie Ruch, Julien Pierson, Noémie Thomas, Muriel Barberi-Heyob
Non-targeted effects of radiation therapy for glioblastoma
Heliyon
excess body weight alzheimers disease ad disproportionately affect older african americans midlife obesity increases risk ad data exist relationship latelife obesity ad obesitybased genetic risk ad interact although apoe4 allele confers strong genetic risk ad unclear latelife obesity poses greater risk apoe4 carriers compared noncarriers assessed 1 influence body mass index bmi normal overweight class 1 obese class 2 obese cognitive structural mri measures ad risk 2 interaction bmi apoe4 older african americans seventy cognitively normal older african american participants mage 6950 years mbmi 3101 kgm2 39 apoe4 allele carriers 86 female completed anthropometric measurements physical assessments saliva collection apoe4 genotyping cognitive testing health lifestyle questionnaires structural neuroimaging volumesurface area sa medial temporal lobe subregions hippocampal subfields covariates included age sex education literacy depressive symptomology estimated aerobic fitness using ancovas observed individuals overweight demonstrated better hippocampal cognitive function generalization learning sensitive marker preclinical ad individuals normal bmi p 0016 p2 018 however individuals obese categories apoe4 noncarriers larger hippocampal subfield cornu ammonis region 1 ca1 volumes apoe4 carriers smaller ca1 volumes p 0003 p2 023 thus overweight bmi standards may preserve hippocampal function obesity reduces hippocampal structure function older african americans apoe4 alzheimers disease risk allele