Samantha L Quaife|Mamta Ruparel|Rebecca J. Beeken|Andy McEwen|John Isitt|Gary Nolan|Karen Sennett|David R Baldwin|Stephen W. Duffy|Sam M. Janes|Jane Wardle
The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and ‘hard-to-reach’ patients
University College London|University College London|University College London|University College London|Nottingham University Hospitals NHS Trust|Queen Mary University of London|University College London|University College London
participation lowdose ct ldct lung cancer screening offered trial context poor especially among smokers socioeconomically deprived backgrounds group riskbenefit ratio improved due high risk lung cancer attracting high risk participants essential success equity future screening programme study investigate whether observed low biased uptake screening improved using targeted invitation strategy randomised controlled trial design used test whether targeted invitation materials effective improving engagement offer lung cancer screening high risk candidates two thousand patients aged 6075 recorded smoker within last five years gp identified primary care records individually randomised receive either intervention invitation materials take targeted stepped low burden approach information provision prior appointment control invitation materials primary outcome uptake nurseled lung health check hospital appointment patients offered spirometry test exhaled carbon monoxide co reading ldct eligible initial data demographics ie age sex ethnicity deprivation score smoking status collected primary care analysed explore differences attenders nonattenders respect invitation group attend lung health check data smoking collected appointment including packyear history nicotine dependence confidence quit secondary outcomes include willingness screened uptake ldct measures informed decisionmaking ensure latter compromised either invitation strategy effective improving informed uptake screening reducing bias participation invitation strategy could adopted local screening pilots national programme study registered isrctn international standard registered clinicalsocial study number isrctn21774741 23rd september 2015 nih clinicaltrialsgov database nct0255810 22nd september 2015