Marta Angélica Iossi Silva, Beatriz Pereira, Denisa Mendonça, Berta Nunes, Wanderlei Abadio de Oliveira
The involvement of girls and boys with bullying: an analysis of gender differences
International journal of environmental research and public health
tuberous sclerosis complex tsc rare genetic disease manifests early symptoms including cortical malformations childhood epilepsy tscassociated neuropsychiatric disorders tands cortical malformations arise embryonic development linked childhood epilepsy underlying mechanisms relationship remain insufficiently understood zebrafish emerged convenient model study elementary neurodevelopment however without indepth functional analysis tsc2deficient zebrafish line cannot used studies tands new drug screening study found lack tsc2 zebrafish resulted heterotopias hyperactivation mtorc1 pathway pallial regions homologous mammalian cortex observed commissural thinning responsible brain dysconnectivity recapitulating tsc pathology human patients lack tsc2 also delayed axonal development caused aberrant tract fasciculation corresponding abnormal expression genes involved axon navigation mutants underwent epileptogenesis resulted nonmotor seizures exhibited increased anxietylike behavior mapped discrete parameters locomotor activity epilepsylike anxietylike behaviors rescued reducing tyrosine receptor kinase b trkb signaling moreover contrast treatment vigabatrin rapamycin trkb inhibition rescued brain dysconnectivity anxietylike behavior data reveal commissural thinning results aberrant regulation anxiety providing mechanistic link brain anatomy human tands findings also implicate trkb signaling complex pathology tsc reveal therapeutic target