Yusuke Matsuyama, Aya Isumi, Satomi Doi, Takeo Fujiwara
69th Annual ORCA Congress 2022
Caries research
study explores impact significant interpretative breakpoint changes aminoglycosides piperacillintazobactam enterobacterales pseudomonas aeruginosa considering pkpd clinical data susceptibility clinical reporting use january 2021 june 2023 total 189583 samples processed bacterial pathogens antimicrobial susceptibility testing performed using disc diffusion methodvitek 2 compact systembroth microdilution whonet software utilised capture analyse changes interpretation disc diffusion method following updates clsi m100 documents comparison previous editions antimicrobial consumption data collected interpreted ddd100 bed days using amc tool software present data 13615 members order enterobacterales 1793 pseudomonas aeruginosa isolates enterobacterales exhibited significant susceptibility drop 147 gentamicin 217 amikacin pseudomonas aeruginosa showed increase isolates intermediate tobramycin susceptibility 06 297 relatively minor changes piperacillintazobactam interpretation changes indicate shift toward increased resistance intermediate susceptibility antibiotics emphasizing need cautious use leveraging pkpd knowledge improved antibiotic utilization patient outcomes antimicrobial stewardship