Rida Naaem, Furqan Khurshid Hashmi, Sulaman Yaqub, Dzul Azri Mohamed Noor
Qualitative assessment of knowledge, attitude and practice of oncologists about precision medicine in cancer patients- study from Lahore, Pakistan
PloS one
monitoring disease progression childhood interstitial lung diseases child essential information minimal important difference mid defined smallest change parameter perceived important prompting clinician change treatment available calculated mids vital signs respiratory rate peripheral oxygen saturation room air fan severity score healthrelated quality life hrqol scores study used data kids lung register webbased management platform collects data rare paediatric lung disorders focus child data vital signs hrqol scores health status questionnaire childspecific questionnaire pedsql v40 collected mids calculated according distributionbased onethird sd anchorbased methods using forced expiratory volume 1 forced vital capacity anchors baseline data 774 children used calculate following mids respiratory rate 13 zscore o2 saturation room air 30 fan severity score 0204 health status questionnaire 0408 childspecific questionnaire 4482 physical health summary score 7889 psychosocial health summary score 3469 total score 5174 results responsiveness analysis generally agreed mids calculated first time provide estimates mids vital signs hrqol scores large cohort child using different methods