Jason A Mendoza, Wren Haaland, Maya Jacobs, Mark Abbey-Lambertz, Josh Miller, Deb Salls, Winifred Todd, Rachel Madding, Katherine Ellis, Jacqueline Kerr
Bicycle Trains, Cycling, and Physical Activity: A Pilot Cluster RCT
American journal of preventive medicine
describe construction digital brain atlas composed data manually delineated mri data total 56 structures labeled mri 40 healthy normal volunteers labeling performed according set protocols developed project pairs raters assigned structure trained protocol structure rater pair tested concordance 6 40 brains achieved reliability standards divided task delineating remaining 34 brains data spatially normalized wellknown templates using 3 popular algorithms air525s nonlinear warp woods et al 1998 paired icbm452 warp 5 atlas rex et al 2003 fsls flirt smith et al 2004 paired template skullstripped version icbm152 t1 average spm5s unified segmentation method ashburner friston 2005 paired canonical brain whole head icbm152 t1 average thus produced 3 variants atlas constructed 40 representative samples data processing stream one might use analysis normalization algorithm individual structure delineations resampled according computed transformations next computed averages voxel location estimate probability voxel belonging 56 structures version atlas contains every voxel probability densities region thus providing resource automated probabilistic labeling external data types registered standard spaces also computed average intensity images tissue density maps based three methods target spaces atlases serve resource diverse applications including metaanalysis functional structural imaging data bioinformatics applications display arbitrary labels probabilistically defined anatomic space facilitate knowledgebased development visualization findings multiple disciplines