Fearn Bishop, Johannes Zagermann, Ulrike Pfeil, Gemma Sanderson, Harald Reiterer, Uta Hinrichs
Construct-A-Vis: Exploring the Free-Form Visualization Processes of Children
IEEE transactions on visualization and computer graphics
quantitative proteomics enhanced capability study protein dynamics involvement disease using various techniques including statistical testing discern significant differences conditions focus different conditions exploring similarities provide valuable insights however exploring similarities directly analyte level proteins genes metabolites standard practice widely adopted study propose statistical framework called questvar quantitative exploration stability variability statistical hypothesis testing enabling exploration quantitative stability variability features combined statistical framework questvar utilizes differential equivalence testing expand statistical classifications analytes comparing conditions applied method extensive data set cancer cell lines revealed quantitatively stable core proteome across diverse tissues cancer subtypes functional analysis set proteins highlighted molecular mechanism cancer cells maintain constant conditions tumorigenic environment via biological processes including transcription translation nucleocytoplasmic transport