Lisa K Gilbert, Jane Bulger, Kelli Scanlon, Linda Moyer
Viral hepatitis prevention education: what do people and providers need to know?
Patient education and counseling
recurrent implantation failure rif challenging clinical situation various strategies tried improve pregnancy rate rif plateletrich plasma prp obtained autologous blood samples person multiple times richer platelets growth factors helps improve endometrial receptivity study conducted summarise evidence quality evidence available far regarding role prp cases unexplained rif electronic database search randomised clinical trials comparing prp routine care women unexplained rif performed pubmed embase scopus cochrane central two independent reviewers conducted literature search retrieved data using predefined eligibility criteria bias assessment done using cochrane collaboration network risk bias tool version 2 quality evidence determined summary findings table prepared individual outcomes using gradepro software identified 1146 records removing duplicates 531 records screened 22 studies reached fulltext screening nine studies included final review uncertain effect prp due low quality evidence little confidence administration prp significant effect improving live birth rate women rif odds ratio 732 95 confidence interval ci 4541181 i2 40 similarly quality evidence low clinical pregnancy rate uncertain administration prp significant effect clinical pregnancy rate 320 95 ci 238428 i2 0 current review suggests may beneficial effects prp women rif quality evidence low uncertain benefit little confidence findings limitations small sample size studies short followup period nonuniformity definition outcomes low quality evidence protocol registered prospero crd42021292209