Vincent Mok|Alexander Wong|Stanley Ho|Thomas W. Leung|Wynnie W.M. Lam|Ka Sing Wong
Rivastigmine in Chinese patients with subcortical vascular dementia
Chinese University of Hong Kong
background explored efficacy tolerability rivastigmine among chinese patients subcortical vascular dementia methods forty subjects randomized either placebo n 20 rivastigmine n 20 doubleblind 26week trial outcome measures cognition minimental state examination frontal assessment battery neuropsychiatric inventory npi instrumental activities daily living clinical dementia rating scale adverse events results statistical significant benefit could observed active group efficacy measures trend favoring active group observed npi subscore irritability p 0066 aberrant motor behavior p 0068 withdrawal rate 30 15 active placebo group respectively conclusion among chinese subcortical vascular dementia patients apparent cognitive benefit associated use rivastigmine 6 months period trend favoring rivastigmine observed certain behavioral measures rivastigmine associated withdrawals relative placebo keywords rivastigmine subcortical vascular dementia chinese