Ainara Garde, Manil Chowdhury, Aryannah U Rollinson, Mika Johnson, Paul Prescod, Jean Pierre Chanoine, John Mark Ansermino, Guy A Dumont
A Multi-Week Assessment of a Mobile Exergame Intervention in an Elementary School
Games for health journal
investigate possible crosstalk genes associated pathways transcription factors chronic periodontitis cp chronic obstructive pulmonary disease copd gene expression profiles cp gse10334 gse16134 copd gse76925 downloaded geo database differential expression functional clustering analyses performed proteinprotein interaction ppi network constructed core crosstalk genes filtered using four topological analysis algorithms modular segmentation functional clustering analysis performed gse10334 detected 164 differentially expressed genes degs 119 upregulated 45 downregulated gse16134 identified 208 degs 154 upregulated 54 downregulated gse76925 identified 1 408 degs 557 upregulated 851 downregulated ppi network included 21 nodes 20 edges final screening included seven crosstalk genes cd79a fcrla cd19 irf4 cd27 sell cxcl13 relevant pathways included primary immunodeficiency bcell receptor signaling pathway cytokinecytokine receptor interaction study indicates probability shared pathophysiology cp copd crosstalk genes associated pathways transcription factors may offer novel concepts future mechanistic investigations