Charles G Jose, Rachel Lucy, Alma Manabat Parker, Joana Clere, Linda Montecillo, Allison M Cole
Pakikisama: Filipino Patient Perspectives on Health Care Access and Utilization
Journal of the American Board of Family Medicine : JABFM
childhood obesity nutritionrelated disease multiple underlying aetiologies genetic factors contribute obesity gut microbiome also implicated fermentation nondigestible polysaccharides shortchain fatty acids scfa provide energy host postulated act signalling molecules affect expression gut hormones study cumulative association causal regulatory tagged single nucleotide polymorphisms snps within genes involved scfa recognition metabolism obesity study participants nonhispanic white nhw n 270 nonhispanic black nhb n 113 children 25 years synergistic theory research obesity nutrition group strong kids 1 study snp variables assigned values according additive dominant recessive inheritance models weighted genetic risk scores grs constructed multiplying reassigned values independently generated coefficients summing coefficients ethnicityspecific snps selected inclusion grs cohort grs directly associated body mass index bmi zscore models explained 375 129 267 variance nhwnhb nhw nhb 089 ci 043135 p 00002 078 ci 054103 p 00001 074 ci 051097 p 00001 analysis supports cumulative association several candidate genetic variants selected role scfa signalling transport metabolism earlyonset obesity data strengthen concept microbiome influences obesity development host genes interacting scfa