Yilin Ye, Hongran Ma, Jiyuan Dong, Jiancheng Wang
Association between short-term ambient air pollutants and type 2 diabetes outpatient visits: a time series study in Lanzhou, China
Environmental science. Processes & impacts
backgroundpurpose previous epidemiological studies associated interstitial lung disease ild rheumatoid arthritis ra yet causality relationship remains uncertain study aimed investigate genetic causal link ild ra methods genomewide association study gwas statistics ild ra collected public datasets relevant singlenucleotide polymorphisms snps selected executing quality control steps gwas summary results twosample bidirectional mendelian randomization mr analysis performed assess causal relationship two conditions mr analysis primarily used inverse variance weighting ivw weighted median wm mregger regression methods sensitivity analyses including mregger leaveoneout mr pleiotropy residual sum outlier mrpresso conducted evaluate heterogeneity pleiotropy replication analyses using asian datasets also conducted enhance robustness findings results european population ra found increase risk ild 96 1096 95 ci 10231174 p 0009 conversely ild associated 128 increased risk ra 1128 95 ci 10131256 p 0029 replication analyses asian gwas supported findings particularly increased risk ild attributable ra 133 95 ci 118149 pvalue 0001 conclusion findings underscore clinical importance screening ild ra patients suggest effective management ra could significantly benefit ild patients potential applicability novel ra treatments ild warrants exploration additionally racial disparities manifestation diseases overlooked may offer new perspectives targeted therapies diverse populations