Reshmi Marhe|Maartje Luijten|B.J.M. van de Wetering|Marion Smits|Ingmar H.A. Franken
Individual Differences in Anterior Cingulate Activation Associated with Attentional Bias Predict Cocaine Use After Treatment
Erasmus University Rotterdam|Erasmus University Rotterdam|Bouman GGZ|Erasmus MC|Erasmus MC
drugdependent patients often relapse drug use treatment behavioral studies show enhanced attentional bias drug cues precursor relapse present functional magnetic resonance imaging fmri study examined whether brain regions involved attentional bias predictive cocaine use treatment attentional biasrelated brain activity measuredwith cocaine stroop taskin cocainedependent patients first week detoxification treatment used predict cocaine use 3month followup predictive value attentional biasrelated brain activity priori defined regions interest addition measures selfreports substance severity craving behavioral attentional bias examined results show craving week treatment individual variability attentional biasrelated activity dorsal anterior cingulate cortex dacc significant predictors days cocaine use 3month followup accounted 45 explained variance brain activity dacc uniquely contributed 22 explained variance prediction model findings suggest hyperactive attentional biasrelated brain activity dacc might biomarker relapse vulnerability early first week detoxification treatment ultimately may help develop individually tailored treatment interventions reduce relapse risk