Kristine A Madsen, Hannah R Thompson, Jennifer Linchey, Lorrene D Ritchie, Shalika Gupta, Dianne Neumark-Sztainer, Patricia B Crawford, Charles E McCulloch, Ana Ibarra-Castro
Effect of School-Based Body Mass Index Reporting in California Public Schools: A Randomized Clinical Trial
JAMA pediatrics
understanding psychiatric symptoms alzheimer disease ad crucial advancing precision medicine therapeutic strategies relationship ad behavioral symptoms asymmetry spatial tau pet patterns wellknown braak tau progression implicates temporal lobes early however clinical pathological implications temporal tau laterality remain unexplored crosssectional study investigated correlation temporal tau pet asymmetry behavior assessed using neuropsychiatric inventory composite scores memory executive function language using data alzheimers disease neuroimaging initiative adni dataset entire cohort continuous right left temporal tau contributions behavior cognition evaluated controlling age sex education tau burden contralateral side additionally temporal tau laterality index calculated define asymmetryextreme groups individuals laterality indices greater two standard deviations mean 695 individuals age 739 76 years 372 535 females included comprising 281 40 cognitively unimpaired cu amyloid negative 185 27 cu amyloid positive 229 33 impaired ci amyloid positive participants full cohort analysis right temporal tau associated worse behavior b 814 pvalue 0007 left temporal tau associated worse language b 14 pvalue 0001 categorization asymmetryextreme groups revealed 20 right 27 leftasymmetric participants within extreme groups additional heterogeneity along anteriorposterior dimension asymmetrical tau burden associated distinct behavioral cognitive profiles wide multicultural implementation social cognition measures needed understand rightsided asymmetry ad