Fadia Fakhre, Danny J Soares
Practice-Based Learning in Aesthetic Medicine: Assessing Scientific Literacy Among Cosmetic Practitioners
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
challenge solving genotypetophenotype relationship predict cells metabolome believed correlate poorly gene expression using comparative quantitative proteomics found differential protein expression 97 saccharomyces cerevisiae kinase deletion strains nonredundant dominated abundance changes metabolic enzymes associating differential enzyme expression landscapes corresponding metabolomes using network models provided reasoning poor proteomemetabolome correlations differential protein expression redistributes flux control many enzymes acting concert mechanism captured onetoone correlation statistics mapping regulatory patterns using machine learning enabled prediction metabolite concentrations well identification candidate genes important regulation metabolism overall study reveals large part metabolism regulation explained coordinated enzyme expression changes quantitative data indicate mechanism explains half metabolism regulation underlies interdependency enzyme levels metabolism renders metabolome predictable phenotype