R. W. Evans|Natalie Joseph?Williams|Adrian Edwards|Robert G. Newcombe|Patricia Wright|Paul Kinnersley|J. D. Griffiths|Michael D. Jones|Janet E. Williams|Richard Grol|Glyn Elwyn
Supporting Informed Decision Making for Prostate Specific Antigen (PSA) Testing on the Web: An Online Randomized Controlled Trial
Cardiff University|Cardiff University|Cardiff University|Cardiff University|Cardiff University|Cardiff University|Cardiff University|Cardiff University|Cardiff University|TropIQ Health Sciences|Radboud University Nijmegen|Cardiff University
men considering prostate specific antigen psa test prostate cancer increasingly common male cancer encouraged make informed decisions test limited accuracy natural history condition poorly understood webbased psa decision aid prosdex developed part uk prostate cancer risk management programme order help men make informed decisionsthe aim study evaluate effect webbased psa decision aid prosdex informed decision makinga webbased randomized controlled trial conducted south wales united kingdom men aged 50 75 previously psa test randomly allocated two intervention two control groups participants intervention groups either viewed prosdex given paper version text main outcome measures three components informed decision making 1 knowledge prostate cancer psa 2 attitude toward psa testing 3 behavior using proxy measure intention undergo psa testing decisional conflict anxiety also measured uptake psa test outcomes measured means online questionnaire prosdex group paper version group one two control groups six months later psa test uptake ascertained general practitioners records online questionnaire repeated results reported terms mannwhitney ustatistic divided product two sample sizes umm line effect 050participants 514 men compared control group completed initial online questionnaire men prosdex group increased knowledge psa test prostate cancer umn 070 95 ci 062 076 less favourable attitudes psa testing umn 039 95 ci 031 047 less likely undergo psa testing umn 040 95 ci 032 048 less decisional conflict umn 032 95 ci 025 040 anxiety level differ umn 050 95 ci 042 058 outcomes significant differences men prosdex group paper version group however prosdex group increased knowledge associated less favourable attitude toward testing spearman rank correlation rho 049 p 001 lower intention undergo testing rho 027 p 02 six months psa test uptake lower prosdex group paper version questionnaire control group p 014 test uptake also lower control group complete questionnaire control group suggesting possible hawthorne effect questionnaire favour psa testingexposure prosdex associated improved knowledge psa test prostate cancer men high level knowledge less favourable attitude toward less likely undergo psa testing prosdex appears promote informed decision making regarding psa testisrctn48473735 httpwwwcontrolledtrialscomisrctn48473735 archived webcite httpwwwwebcitationorg5r1tlq5nk