Hal H. Atkinson|Caterina Rosano|Eleanor M. Simonsick|Jeff D. Williamson|Cralen Davis|Walter T. Ambrosius|Stephen R. Rapp|Matteo Cesari|Anne B. Newman|Tamara B. Harris|Susan M. Rubin|Kristine Yaffe|Suzanne Satterfield|Stephen B. Kritchevsky
Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study
Wake Forest University|Winston-Salem/Forsyth County Schools|University of Pittsburgh|Institute on Aging|National Institute on Aging|Wake Forest University|Winston-Salem/Forsyth County Schools|Faculty of Public Health|Faculty of Public Health|Wake Forest University|University of Florida|University of Pittsburgh|Institute on Aging|National Institute on Aging|University of California, San Francisco|University of California, San Francisco|University of Tennessee Health Science Center|Wake Forest University|Winston-Salem/Forsyth County Schools
backgroundemerging evidence indicates association cognitive function physical performance late lifethis study examines relationship cognitive function subsequent gait speed decline among highfunctioning older adults methods measures global cognitive function modified mini mental state examination 3ms executive control function ecf clock drawing task clox 1 15item executive interview exit 15 obtained health aging body composition study 19992000gaitspeed meterssecond assessed 20 meters usual paceusing mixed model assessed relationship baseline cognitive function gaitspeed change 3 yearsresultstwo thousand three hundred fortynine older adults mean age 756 6 29 years completed assessmentsafter adjustment baseline gait speed 1standarddeviation sd lower performance cognitive test associated greater gaitspeed decline 3 years 0016 ms 3ms sd 81 0009 ms clox 1 sd 24 0012 ms exit 15 sd 41 p 0005 allafter adjustment comorbidities effect size attenuated 3ms clox 1 association exit 15 longer significantdepression score strongly associated exit 15 effect reduction conclusionglobal executive cognitive functions predict declines gait speedthe association ecf gait speed decline attenuated comorbid conditions particularly depressionelucidation mechanisms underlying associations may point new pathways treatment physical decline associated diminished cognitive function