Paula Aristizabal|Jenelle Singer|Renee Cooper|Kristen J. Wells|Jesse Nodora|Mehrzad Milburn|Sheila Gahagan|Deborah Schiff|Mar??a Elena Mart??nez
Participation in pediatric oncology research protocols: Racial/ethnic, language and age?based disparities
University of California, San Diego|Rady Children's Hospital-San Diego|University of California, San Diego|San Diego State University|San Diego State University|University of California, San Diego|University of California, San Diego|University of California, San Diego|University of California, San Diego|Rady Children's Hospital-San Diego|University of California, San Diego|Rady Children's Hospital-San Diego|University of California, San Diego
background survival rates pediatric oncology improved dramatically part due high patient participation clinical trials although racialethnic inequalities clinical trial participation reported adults pediatric data studies comparing participation rates sociodemographic characteristics scarce goal study assess differences research protocol participation childhood cancer age sex raceethnicity parental language cancer type insurance status procedure data enrollment protocol biospecimen therapeutic protocols collected analyzed newly diagnosed pediatric patients cancer 20082012 rady childrens hospital results among 353 patients included analysis 304 861 enrolled protocol enrollment biospecimen therapeutic protocols 842 261310 811 206254 respectively logistic regression analyzes revealed significant enrollment underrepresentation protocol hispanics compared nonhispanic whites 81 vs 91 odds ratio 043 95 confidence interval ci 021090 p 0021 among children spanishspeaking vs englishspeaking parents 78 vs 89 045 95ci 023087 p 0016 compared patients aged 04 years significant underrepresentation also found among patients 1521 years old 92 vs72 021 95 ci 009048 p lt 0001 similar trends observed analyzing enrollment biospecimen therapeutic protocols separately conclusions significant underrepresentation protocol participation hispanics children spanishspeaking parents patients ages 1521 research needed understand barriers research participation among groups underrepresented pediatric oncology clinical trials pediatr blood cancer 20156213371344 2015 wiley periodicals inc