Hanife Gülden Düzkalir, Barış Genç, Safiye Güneş Sağer, Ayberk Türkyilmaz, Hediye Pınar Günbey
Microstructural evaluation of the brain with advanced magnetic resonance imaging techniques in cases of electrical status epilepticus during sleep (ESES)
Turkish journal of medical sciences
context traumatic brain injury tbi common acquired childhood disability may used model understand completely impact early brain injury brain structure daytoday function contrary previously held views plasticity young brain recent research suggests early insults may profound impact development date suggestions remain largely untested objectives plot changes cognitive abilities childhood tbi 30 months injury examine impact age injury cognitive outcomes design prospective longitudinal study setting royal childrens hospital victoria australia main outcome measures global intellectual ability verbal nonverbal skills attention processing speed participants total 122 children admitted hospital diagnosis tbi divided according injury age ie young age 37 years old age 812 years injury severity mild moderate severe evaluated acutely 12 30 months injury additional sample children injured 3 years age n 27 compared groups respect global intellectual ability results clear relationship documented injury severity cognitive performance children sustained severe injury younger age injury associated minimal recovery injury better outcomes observed severe tbi among older children age injury predictive outcomes children mild moderate tbi although infants age 0211 years moderate tbi showed poorer outcomes older children injury similar severity conclusions findings support doublehazard model severe early brain insults add ongoing debate regarding cerebral plasticity suggesting contrary traditional views young children sustain severe tbi early childhood moderate severe tbi infancy may particularly vulnerable significant residual cognitive impairment clinical perspective results indicate longterm followup monitoring management targeted highrisk group