Gary R Maslow, Sherika N Hill
Systematic review of character development and childhood chronic illness
World journal of clinical pediatrics
introduction achieve optimized blood glucose concentrations assessed hba1c high healthrelated quality life hrql children adolescents diabetes mellitus type 1 t1dm must follow strict disease management strategies study aims investigate hrql children adolescents t1dm association hba1c values course 6 months methods patients aged 717 years n 203 t1dm provided hrql data monthly basis hrql measured using kidscat computeradaptive test cat comprising five generic hrql domains hba1c concentrations assessed baseline 3 6 months explored trajectory hrql domain level using linear mixed effects models investigated association hrql hba1c concentrations time using path analysis models results children adolescents t1dm reported high scores across hrql domains time however hba1c concentrations 90 reported significantly lower scores physical wellbeing parent relations compared hba1c concentration 75 path analysis models revealed minimal temporal relationship hba1c hrql small negative impact hba1c physical wellbeing psychological wellbeing parent relations conclusion although observed hrql young patients t1dm comparable agerelated germanspeaking reference population course 6 months hba1c concentration 90 reported lower scores selected hrql domains thus special attention drawn hrql children adolescents higher hba1c concentrations minimal relationship hba1c hrql indicates two therapy goals ie achievement maintenance glycemic targets high hrql considered evaluated independently clinical routine trial registration drks00006326 german clinical trial register date registration august 1st 2014