Riya Singla, Pratik Chatterjee, Prasanna Mithra
Impact of COVID-19 on Academic and Psychological Aspects in Students of Medicine: A Cross-Sectional Study
Cureus
study investigates degradation processes three antimicrobials water norfloxacin ciprofloxacin sulfamethoxazole photolysis focusing prediction toxicity endpoints via silico quantitative structureactivity relationship qsar transformation products tps photolysis experiments conducted distilled water individual solutions 10 mg l1 compound identification tps performed means lctofms employing method based retention time exact mass fragmentation pattern peak intensity ten main compounds identified sulfamethoxazole fifteen ciprofloxacin fifteen norfloxacin 40 identified tps 6 reported literature based new data found work tps already reported literature proposed degradation pathways three antimicrobials providing reasoning identified tps qsar risk assessment carried 74 structures possible isomers qsar predictions showed 19 possible structures sulfamethoxazole tps nonmutagenic whereas 16 toxicant 18 carcinogenic 14 nonreadily biodegradable ciprofloxacin 28 30 possible structures tps mutagenic nonreadily biodegradable structures toxicant carcinogenic 25 possible norfloxacin tps predicted mutagenic toxicant carcinogenic nonreadily biodegradable results obtained silico qsar models evince need performing risk assessment tps well parent antimicrobial expert analysis qsar predictions using different models degradation pathways imperative large variety structures found tps