Hannah C Heims|Hugo Critchley|Raymond J. Dolan|Christopher J. Mathias|Lisa Cipolotti
Social and motivational functioning is not critically dependent on feedback of autonomic responses: neuropsychological evidence from patients with pure autonomic failure
National Hospital for Neurology and Neurosurgery|University College London|University College London|National Hospital for Neurology and Neurosurgery|National Hospital for Neurology and Neurosurgery|University College London|St. Mary's Hospital|University of Palermo
social emotional motivational behaviours associated production automatic bodily responses rerepresentation brain feedback autonomic skeletomuscular arousal proposed underlie feeling states influence emotional judgments bias motivational decisionmaking guide social interactions consistent hypothesis dissocial behaviour deficits emotional motivation tasks associated blunted bodily responses patients orbitofrontal brain lesions developmental psychopathy determine critical dependence social emotional behaviours bodily responses mediated autonomic nervous system examined patients pure autonomic failure paf peripheral denervation autonomic neurons onset middle age compared healthy subjects paf patients unimpaired tests motivational decisionmaking iowa gambling task recognition emotional facial expressions theory mind tasks tests social cognition test emotional attribution perhaps sensitive subjective feeling states paf patients score worse comparison group though evidence deficit specific discrete emotion requires validation findings suggest emotional social functioning critically tied ongoing experience autonomic arousal state acquisition autonomic failure late life may protect maladaptive social behaviour established behavioural responses may associated central representations