Shojiro Hanaki, Shuichi Katayama, Soichi Nakada
The Effectiveness of Pediatric Central Venous Access Device Surveillance and Rounding Team: A Single-Center Study
Cureus
deficits neurocognitive function demonstrated individuals schizophrenia unaffected family members individuals genetic studies complementary traits along traditional analyses diagnosis may help elucidate biological pathways underlying familial liability schizophrenia related disorders authors conducted multiplex multigenerational family study using genomewide screen schizophrenia related neurocognitive phenotypes participants 1 676 european american individuals 43 families ascertained individual schizophrenia 2 236 healthy comparison subjects participants evaluated clinically examined use computerized neurocognitive test battery provided measures accuracy speed cognitive domains abstraction mental flexibility attention verbal face spatial memory language reasoning spatial emotion processing sensorimotor dexterity genomewide linkage screen also performed healthy comparison subjects included order obtain normative phenotypic data genotyped significant evidence linkage schizophrenia chromosome 19q observed analysis cognitive traits revealed significant linkage chromosome 5q domains abstraction mental flexibility variety neurocognitive traits also showed nominal evidence linkage 5q region joint analyses diagnosis suggested quantitative trait locus may also influence schizophrenia although chromosome 5 implicated previous linkage studies schizophrenia identification chromosome 19 quantitative trait locus novel finding identification chromosome 5 quantitative trait locus linkage neurocognitive phenotypes present study may inform functional hypotheses pertaining genotypes connected disease