Vesna Balac, Kori Stewart, Randy Griswold, Richard Carlton, Arlene Adler
Establishing Standardized Terminology for Digital Image Analysis: A Pilot Study
Radiologic technology
insulindependent diabetes mellitus iddm chronic disease characterized inability pancreas produce sufficient amounts insulin daily compensation deficiency requires 46 insulin injections taken daily aim insulin therapy maintain normoglycemia ie blood glucose level 4 7mmoll determine quantity timing injections various different approaches used currently mostly qualitative semiquantitative models reasoning used design therapy attempt made show system identification control may used estimate predictive quantitative models used design optimal insulin regimens system divided three subsystems insulin subsystem glucose subsystem insulinglucose interaction insulin subsystem aims describe absorption injected insulin subcutaneous depots glucose subsystem absorption glucose gut following meal subsystems modeled using compartment models proposed models found literature several blackbox models greybox models describing insulinglucose interaction developed analyzed models fitted real data monitored iddm patient many difficulties encountered typical biomedical systems nonuniform scarce sampling timevarying dynamics severe nonlinearities difficulties encountered modeling none proposed models able describe system accurately aspects conditions however linear models shared dynamics based estimated models shortterm blood glucose predictors twohourahead blood glucose prediction designed furthermore explored issues arise applying prediction theory control shortterm blood glucose prediction