Issiaka Soulama|Issa Nébié|Alphonse Ouédraogo|Adama Gansané|Amidou Diarra|Alfred B. Tiono|Edith C. Bougouma|Amadou T. Konaté|Gustave B. Kabré|Walter R. J. Taylor|Sodiomon B. Sirima
Plasmodium falciparum genotypes diversity in symptomatic malaria of children living in an urban and a rural setting in Burkina Faso
Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Université Joseph Ki-Zerbo|University Hospital of Geneva|Groupe de Recherche et d’Action sur le Foncier
clinical presentation malaria considered result complex interaction parasite human genetics described different rural urban areas analysis plasmodium falciparum genetic diversity children uncomplicated malaria living two different areas may help understand effect urbanization distribution p falciparum genotypesisolates collected 75 89 children uncomplicated malaria infection living rural urban area burkina faso respectively analysed nested pcr amplification msp1 msp2 genes compare p falciparum diversitythe k1 allelic family widespread children living two sites compared msp1 allelic families frequency 90 mad 20 allelic family msp1 prevalent p 00001 urban 853 rural area 632 urban area 3d7 alleles msp2 prevalent compared fc27 alleles high frequency 3d7 300bp allele 30 multiplicity infection range one six urban area one seven rural area difference frequency multiple infections p 06 960 95 ci 916100 urban versus 931 95ci 876986 rural areas complexity infection increased age p 004 rural area p 006 urban areaurbanrural area differences observed allelic families mad20 fc27 3d7 suggesting probable impact urbanization genetic variability p falciparum taken account implementation malaria control measures