Jay Park|Ofir Harari|Louis Dron|Richard Lester|Kristian Thorlund|Edward J. Mills
An overview of platform trials with a checklist for clinical readers
University of British Columbia|McMaster University|Impact|McMaster University|Impact|University of British Columbia|McMaster University|Impact|McMaster University|Impact
objectivesthe objective study outline key considerations general clinical readers critically evaluating publications platform trials researchers designing types clinical trialsstudy design settingin review describe key concepts platform trials case study discussion two hallmark platform trials stampede ispy2 provide readers guide platform trials critical appraisal checklistresultsplatform trials offer flexibilities dropping ineffective arms early based interim data introducing new arms trial platform trials important consider interventions compared evaluated throughout new interventions introduced intervention comparisons important consider primary analysis many interventions active simultaneously allocation different arms interim evaluation considerations include number timing interim evaluations outcomes statistical rules used drop interventions new interventions usually introduced based scientific merits consideration merits important together timing mechanisms new interventions addedconclusionmore efforts needed improve scientific literacy platform trials review provides overview important concepts platform trials