Mauricette Moling Lee, Wern Ee Tang, Helen Elizabeth Smith, Lorainne Tudor Car
Information-seeking behaviour of primary care clinicians in Singapore at the point-of-care: A qualitative study
Health information and libraries journal
adverse drug reactions adrs firstline antituberculosis tb drugs common however reports nationwide epidemiologic studies adrs antitb drugs korea study aimed investigate clinical characteristics various adrs firstline antitb drugs using nationwide database adrs used korea adverse event reporting system kaers database 20092018 study subjects selected using korean standard classification diseases codes pulmonary extrapulmonary tb electronic data interchange codes isoniazid inh rifampicin rif ethambutol etb pyrazinamide pza causality assessment possible probable certain world health organizationuppsala monitoring center system causality category selected total 1562024 adrs reported kidskaers database 2009 2018 adrs firstline antitb drugs 17843 cases 114 common causative drugs rif 287 inh 240 etb 234 pza 239 order 485 cases reported older patients 60 years according organ system gastrointestinal system disorder common 320 followed skin appendage 259 liver biliary system 142 nausea common adr 146 followed hepatic enzyme elevation 142 rash 117 pruritus 91 vomiting 89 urticaria 42 adrs appeared within 1 month adrs neuropathy paresthesia hematologic abnormalities renal function abnormalities liver enzyme abnormality also often reported 2 months data clinically informative recognizing coping adrs antitb drugs