Saida R Sharapova, Elyse Phillips, Karen Sirocco, Jennifer W Kaminski, Rebecca T Leeb, Italia Rolle
Effects of prenatal marijuana exposure on neuropsychological outcomes in children aged 1-11 years: A systematic review
Paediatric and perinatal epidemiology
intranasal administration neuropeptide oxytocin ot yielded inconsistent effects social cognition general cognition individuals schizophrenia sz studies examined whether endogenous peripheral ot levels also associated social general cognition sz current study examined whether plasma ot levels associated performance higherorder social cognition measure ie task requires inferential processes knowledge directly presented social stimuli well domains general cognition participants included 30 individuals sz 21 demographically matched healthy controls cn matrics consensus cognitive battery administered assess neuropsychological impairment relation 7 domains processing speed attentionvigilance working memory verbal learning visual learning reasoningproblem solving social cognition plasma ot levels measured via radioimmunoassay sz significantly lower endogenous ot levels poorer mccb performance 7 domains cn cn sz lower endogenous ot associated poorer social cognition sz lower endogenous ot also associated poorer processing speed working memory significant association ot social cognition cn sz highlights importance endogenous ot levels biological predictor social cognition irrespective clinical status significant associations plasma ot general neurocognition may reflect either anxiolytic effect plasma ot results better neurocognitive performance ots action dopamine enhancement dopamine tone results improved cognition