Punit Tyagi, Mangesh Bhide
Development of a bioinformatics platform for analysis of quantitative transcriptomics and proteomics data: the OMnalysis
PeerJ
three early 20thcentury attempts unifying separate areas biology particular development genetics physiology evolution compared regard success fruitfulness research jacques loebs reductionist project unifying approaches physicochemical explanations richard goldschmidts antireductionist attempts unify integration sewall wrights combination reductionist research vision hierarchical genetic systems loebs program demanding aspects biology including evolution studied methods experimental sciences proved highly successful indispensible higher level investigations even though evolutionary change properties biological systems cannot fully explained molecular level alone goldschmidt appraised pioneer physiological developmental genetics new evolutionary synthesis transcended neodarwinism however study concludes antireductionist attempts integrate genetics development evolution regarded failures dead ends grand speculations based one hand concepts experimental systems vague order stimulate research experiments core parts turned reproducible contrast sewall wright apart one architects neodarwinian synthesis 1930s opened new paths testable quantitative developmental genetic investigations placed research within framework logical reasoning resulted farsighted speculation examinations biological systems related regulation hierarchical genetic subsystems possibly providing mechanism development evolution argue suggestion basing study systems clearly defined properties components proved superior goldschmidts approach studying systems whole attempts integrate different fields early stage may prove futile worse