Lucy Cui, Stephanie Lo, Zili Liu
The Use of Visualizations to Improve Bayesian Reasoning: A Literature Review
Vision (Basel, Switzerland)
increases reconstructive orthopaedic surgery total hip replacement spinal fusion resulting advances surgical practice ageing population lead demand bone graft far exceeds supply consequently number synthetic bonegraft substitutes bgss developed mixed success surgical acceptance skeletal tissue regeneration requires interaction three basic elements cells growth factors gfs permissive scaffold achieved preloading synthetic scaffold gfs preexpanded cells however simpler approach design intrinsic osteoinductivity bgs ie capability recruit stimulate patients gfs stem cells investigation mechanisms controlling bone repair bgss linking interactions local chemical physical environment scientists currently developing osteoinductive materials stimulate bone regeneration control scaffold chemistry structure moreover body research providing foundations future generations bgss bonerepair therapies may ultimately contribute towards improving quality life maintenance skeleton reversal disease states opposed mending broken bones currently practice able grow bones bioreactor use autologous graft materials future could surgery limited accidental trauma cases greater restoration function biochemical gene therapies technology research probes necessary task currently developed advent nanotechnology genomics proteomics embark chemical revolution medicine paper aims discuss current thinking mechanisms behind bioactivity biocompatibility bone fuller understanding interactions cells materials used today could bring completely new approaches treatment bone fracture disease tomorrow