Younyoung Choi, Joo Yeon Shin
Assessing quality of life among elementary school students: Validation of the Korean version of the Meaning in Life in Children Questionnaire
Frontiers in psychology
develop osmotically controlledrelease gastroprokinetic metoclopramide hcl tablets using quality design qbdnumerical graphical optimization technique treatment gastroparesis prophylaxis delayed nausea vomiting induced lowhigh emetogenic chemotherapy formulations designed central composite design using design expert version 1100 osmogen concentration x1 orifice size x2 tablet weight gain coating x3 input invitro drug release 1hr y1 6 hrs y2 12 hrs y3 regression coefficient drug release data fitted zeroorder rsq zero y4 output variables core tablets prepared direct compression coated opadry ca experimental design validated polynomial equation correlation predicted observed values evaluated random checkpoint analysis optimized formulations characterized drug release ph effect osmolarity agitation intensity surface morphology stability study subjected accelerated studies according ich guidelines interaction charts response surface plots deduced significant simultaneous effect x variables vitro drug release rsq zero numerical optimization model predicted 90 drug release x1 1330 x2 06 mm x3 796 random checkpoint analysis showed good correlation predicted observed values optimized formulation followed zeroorder kinetics r209703 drug release shelf life calculated 28 years per ich guidelines qbdbased approach found successful developing controlled release osmotic tablets metoclopramide hcl reducing dosage frequency better emetic control improve patient compliance