Shivayogi R Bhusnurmath, Bharti S Bhusnurmath, Shefali B Goyal
Helping medical students to learn pathology more effectively
Indian journal of pathology & microbiology
thromboangiitis obliterans tao vascular condition characterized poor prognosis unclear etiology study employs mendelian randomization mr investigate causal impact circulating inflammatory proteins tao mr analysis summary statistics genomewide association study metaanalysis 91 inflammationrelated proteins integrated independently sourced tao data finngen consortiums r10 release methods inverse variance weighting mregger regression weighted median approaches mrpresso multivariable mr mvmr analysis utilized analysis indicated association higher levels cc motif chemokine 4 reduced risk tao odds ratio 044 95 confidence interval ci 029067 p 14 104 adjusted p 0013 similarly glial cell linederived neurotrophic factor exhibited suggestively protective effect tao 043 95 ci 022081 p 0010 adjusted p 0218 conversely higher levels cc motif chemokine 23 suggestively linked increased risk tao 188 95 ci 121293 p 0005 adjusted p 0218 sensitivity analysis mvmr revealed evidence heterogeneity pleiotropy study identifies cc motif chemokine 4 glial cell linederived neurotrophic factor potential protective biomarkers tao whereas cc motif chemokine 23 emerges suggestive risk marker findings elucidate potential causal relationships highlight significance proteins pathogenesis prospective therapeutic strategies tao