Margaret J Trost, Ann H Allen, Monique Naifeh, Ashlie Tseng, Allyson McDermott, Snehal Shah, Jeffrey C Winer, Erik Hoefgen, Joanna Thomson, Robert A Dudas
Characteristics of Pediatric Hospital Medicine Fellowship Program Directors
Hospital pediatrics
black cohosh red clover hops chasteberry botanicals commonly used alleviate menopausal symptoms us examined study part fda office womens health research collaboration expand knowledge safety botanical products computational approaches using classic quantitative structureactivity relationships qsar probabilistic reasoning machine learning methods human expert rulebased systems employed deliver human hepatobiliary adverse effect predictions objective profile analyze constituents alerting human hepatobiliary adverse effects computational analysis positively predicted constituents showed common structural features contributing hepatobiliary adverse effect predictions contain phenolic flavone isoflavone glucoside conjugated flavone isoflavone 4hydroxyacetophenone structures specifically protocatechuic acid black cohosh benzofuran 4vinylphenol chasteberry xanthohumol hops botanical constituents predicted positive liver toxicity endpoints also confirmed literature findings however comparison estimated human exposure botanical constituents loael noael published animal liver toxicology studies constituents demonstrated varying margins safety study serve regulatory decision support information regulators fda help process prioritizing chemicals testing