Daniel W. Belsky|Terrie E. Moffitt|David L. Corcoran|Benjamin W. Domingue|HonaLee Harrington|Sean Hogan|Renate Houts|Sandhya Ramrakha|Karen Sugden|Benjamin Williams|Richie Poulton|Avshalom Caspi
The Genetics of Success
Duke University|Social Science Research Council|Duke University|Center for Genomic Science|King's College London|Center for Genomic Science|Duke University|Stanford University|Duke University|University of Otago|Duke University|University of Otago|Duke University|Duke University|University of Otago|Duke University|Center for Genomic Science|King's College London
previous genomewide association study gwas 100000 individuals identified moleculargenetic predictors educational attainment undertook indepth lifecourse investigation polygenic score derived gwas using fourdecade dunedin study n 918 five main findings first polygenic scores predicted adult economic outcomes even accounting educational attainments second genes environments correlated children higher polygenic scores born betteroff homes third childrens polygenic scores predicted adult outcomes even analyses accounted socialclass origins socialmobility analysis showed children higher polygenic scores upwardly mobile children lower scores fourth polygenic scores predicted behavior across life course early acquisition speech reading skills geographic mobility mate choice financial planning retirement fifth polygenicscore associations mediated psychological characteristics including intelligence selfcontrol interpersonal skill effect sizes small factors connecting dna sequence life outcomes may provide targets interventions promote populationwide positive development