Marina G Erunova, Oleg E Yakubailik
Methods and technologies for spatial analysis of regional ecosystems based on the watershed approach
Integrated environmental assessment and management
prenatal exposure metals hypothesized associated child autism aim investigate joint individual effects prenatal exposure urine metals including lead pb mercury hg manganese mn selenium se child social responsiveness scale srs scores used data 2 cohorts enriched likelihood autism spectrum disorder asd early autism risk longitudinal investigation earli markers autism risk babieslearning early signs marbles studies metal concentrations measured urine collected pregnancy used bayesian kernel machine regression linear regression models investigate joint independent associations metals srs zscores cohort adjusted maternal age delivery interpregnancy interval maternal education child raceethnicity child sex andor study site final analytic sample consisted 251 motherchild pairs pb hg se mn 75th percentiles 003 increase 95 credible interval ci 011 017 earli 007 decrease 95 ci 029 015 marbles childhood srs zscores compared 4 metals 50th percentiles cohorts increasing concentrations pb associated increasing values srs zscores fixing metals 50th percentiles however 95 credible intervals contained null clear monotonic associations overall prenatal metal mixture pregnancy childhood srs zscores 36 months also clear associations individual metals within mixture childhood srs zscores 36 months overall effects metal mixture individual effects metal within mixture offspring srs zscores might heterogeneous across child sex cohort studies larger sample sizes warranted