Liang Feng|Yuting Liao|Jincai He|Cheng-Long Xie|Siyan Chen|Huihui Fan|Zhi-Peng Su|Zhen Wang
Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease
Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|Wenzhou Medical University|Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|Wenzhou Medical University|Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|First Affiliated Hospital of Wenzhou Medical University|Wenzhou Medical University
long noncoding rna lncrna reported involved pathogenesis neurodegenerative diseases whether serve biomarker alzheimer disease ad yet known present study selected four specific lncrna 17a 51a bace1 bc200 possible ad biomarker rtqpcr performed validate lncrna receiver operating characteristic curve roc area roc curve auc applied study potential lncrna biomarker population 88 ad patients 72 control individuals found plasma lncrna bace1 level ad patients significantly higher healthy controls p 0006 plasma level lncrna 17a 51a bc200 show significant difference two groups p 0098 p 0204 p 0232 respectively roc curve analysis showed lncrna bace1 best candidate lncrna 95 ci 05530781 p 0003 addition correlation found expression lncrna control ad groups age mmse scale p 005 present study compared plasma level four lncrna ad nonad patients found level bace1 increased plasma ad patients high specificity 88 ad indicating bace1 may potential candidate biomarker predict ad