Setegn Eshetie|Mucheye Gizachew|Mulat Dagnew|Gemechu Kumera|Haile Woldie|Fekadu Ambaw|Belay Tessema|Feleke Moges
Multidrug resistant tuberculosis in Ethiopian settings and its association with previous history of anti-tuberculosis treatment: a systematic review and meta-analysis
University of Gondar|University of Gondar|University of Gondar|Debre Markos University|University of Gondar|University of Gondar|Foundation for Innovative New Diagnostics|University of Gondar
efforts control global burden tuberculosis tb jeopardized rapid evolution multidrug resistant mycobacterium tuberculosis mtb resistant least isoniazid rifampicin previous studies documented variable prevalences multidrugresistant tuberculosis mdrtb risk factors ethiopia therefore metaanalysis aimed firstly determine pooled prevalence mdrtb among newly diagnosed previously treated tb cases secondly measure association mdrtb history previous antitb drugs treatmentpubmed embase google scholar databases searched studies reported prevalence mdrtb among new previously treated tb patients selected studies surveys conducted national subnational level reported mdrtb prevalence sufficient data calculate prevalence considered analysis two authors searched reviewed studies eligibility extracted data predefined forms forest plots prevalence estimates performed summary estimates also calculated using random effects models associations previous tb treatment mdrmtb infection examined subgroup analyses stratified new previously treated patientswe identified 16 suitable studies found overall prevalence mdrtb among newly diagnosed previously treated tb patients 2 95 ci 1 2 15 95 ci 12 17 respectively observed difference statistically significant p 0001 odds ratio 81 95 ci 7587 previously treated tb patients develop mdrmtb infection compared newly diagnosed cases past 10 years 2006 2014 overall mdrtb prevalence showed stable time trendthe burden mdrtb remains high ethiopian settings especially previously treated tb cases previous tb treatment powerful predictor mdrmtb infection strict compliance antitb regimens improving case detection rate necessary steps tackle problem ethiopia