Liliana Dell'Osso, Giulia Amatori, Federico Giovannoni, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita
Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits
CNS spectrums
genomics grown exponentially last decade common variants associated physiological changes statistical strategies genomewide association studies gwas quantitative trail loci qtl rare variants associated diseases extensive filtering tools including population genomics triobased sequencing parents probands however genomic associations require followup analyses narrow causal variants identify genes influenced determine physiological changes large quantities data exist used connect variants gene changes cell types protein pathways clinical phenotypes animal models establish physiological genomics data combined bioinformatics including evolutionary analysis structural insights gene regulation yield testable hypotheses mechanisms genomic variants molecular biology biochemistry cell culture crispr editing animal models test hypotheses give molecular variant mechanisms variant characterizations significant component educating future professionals undergraduate graduate medical training programs teaching basic concepts terminology genetics learning independent research hypothesis design article goes computational experimental analysis strategies variant characterization provides examples tools applied publications 2022 american physiological society compr physiol 1233033336 2022