Yang Yang|Jonathan D. Sugimoto|M. Elizabeth Halloran|Nicole E. Basta|Dennis L. Chao|Laura Matrajt|Gail E. Potter|Eben Kenah|Ira M. Longini
The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus
Fred Hutch Cancer Center|University of Washington|Fred Hutch Cancer Center|University of Washington|Fred Hutch Cancer Center|University of Washington|Fred Hutch Cancer Center|University of Washington|Fred Hutch Cancer Center|University of Washington|University of Washington Applied Physics Laboratory|University of Washington|Fred Hutch Cancer Center|University of Washington|Fred Hutch Cancer Center|University of Washington
flus tricky tricks vaccination influenza virus singlepoint mutations selected hemagglutinin virus molecule binds sialic acid molecules surface host cells escape neutralization polyclonal antibody responses hensley et al p 734 discovered mice mutations increased viruss avidity sialic acid amino acid substitutions occur reiterations immune escape avidity modulation thus drive antigenic variation constant evolution influenza viruses requires us change vaccine components annually equine influenza park et al p 726 show match virus vaccine strains drifts apart time probability becoming infected length infectious period increase point outbreaks occur nevertheless even imperfect vaccines may benefit population increasing proportion vaccinated individuals supply enough herd immunity offset poor antigenic match especially used conjunction antiviral drugs humans yang et al p 729 published online 10 september estimate rate transmission within us households puts influenza 2009 h1n1 current pandemic swine flu higher range transmissibility compared past seasonal pandemic strains thus achieve mitigation fall children first recipients vaccine followed adultsaiming overall 70 coverage population