Nirmala Bhoo?Pathy|Mikael Hartman|Cheng?Har Yip|Nakul Saxena|Nur Aishah Mohd Taib|S.P. Lim|Philip Iau|Hans?Olov Adami|Awang Bulgiba|Soo Chin Lee|Helena M. Verkooijen
Ethnic Differences in Survival after Breast Cancer in South East Asia
University Medical Center Utrecht|Hospital Kuala Lumpur|National University of Singapore|National University Health System|University of Malaya|National University Health System|National University of Singapore|University of Malaya|National University Cancer Institute, Singapore|National University Health System|National University of Singapore|Karolinska Institutet|Harvard University|University of Malaya|National University Cancer Institute, Singapore|National University Health System|National University Health System|National University of Singapore|University Medical Center Utrecht
burden breast cancer asia escalating evaluated impact ethnicity survival breast cancer multiethnic region south east asiausing singaporemalaysia hospitalbased breast cancer registry analyzed association ethnicity mortality following breast cancer 5264 patients diagnosed 1990 2007 chinese 716 malay 184 indian 100 compared survival rates ethnic groups calculated adjusted hazard ratios hr estimate independent effect ethnicity survival malays n 968 presented significantly younger age larger tumors later stages chinese indians malays also likely axillary lymph node metastasis similar tumor sizes hormone receptor negative poorly differentiated tumors five year overall survival highest chinese women 758 95ci 744773 followed indians 680 95ci 638722 malays 585 95ci 552617 compared chinese malay ethnicity associated significantly higher risk allcause mortality hr 134 95ci 119151 independent age stage tumor characteristics treatment indian ethnicity significantly associated risk mortality breast cancer compared chinese hr 114 95ci 098134in south east asia malay ethnicity independently associated poorer survival breast cancer research underlying reasons potentially including variations tumor biology psychosocial factors treatment responsiveness lifestyle diagnosis warranted