Vicki S. Conn|Todd Ruppar|Jo?Ana D. Chase|Maithe Enriquez|Pamela S. Cooper
Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis
University of Missouri|University of Missouri|University of Missouri|University of Missouri|University of Missouri
systematic review applied metaanalytic procedures synthesize medication adherence interventions focus adults hypertension comprehensive searching located trials medication adherence behavior outcomes study sample design intervention characteristics outcomes coded randomeffects models used calculating standardized mean difference effect sizes moderator analyses conducted using metaanalytic analogues anova regression explore associations effect sizes sample design intervention characteristics effect sizes calculated 112 eligible treatmentvscontrol group outcome comparisons 34272 subjects overall standardized mean difference effect size treatment control subjects 0300 exploratory moderator analyses revealed interventions effective among female older moderate highincome participants promising intervention components linking adherence behavior habits giving adherence feedback patients selfmonitoring blood pressure using pill boxes special packaging motivational interviewing effective interventions employed multiple components delivered many days future research strive minimizing risks bias common literature especially avoiding selfreport adherence measures