Sachin Shinde, Bernadette Pereira, Prachi Khandeparkar, Amit Sharma, George Patton, David A Ross, Helen A Weiss, Vikram Patel
The development and pilot testing of a multicomponent health promotion intervention (SEHER) for secondary schools in Bihar, India
Global health action
study examined whether polygenic risk scores prs lifetime cannabis alcohol use associated misusing opioids whether sex differences existed relations urban africanamerican sample data drawn three cohorts participants n 1103 45 male recruited first grade part series elementary schoolbased universal preventive intervention trials conducted midatlantic region us young adulthood participants provided dna sample reported whether used heroin misused prescription opioids lifetime three substance use prs computed based prior gwas lifetime cannabis use pasman et al 2018 heavy drinking indexed via maximum number drinks gelernter et al 2019 alcohol consumption kranzler et al 2019 higher prs lifetime cannabis use greater heavy drinking greater alcohol consumption associated heightened risk misusing opioids among whole sample significant sex prs interactions also observed higher prs heavy drinking alcohol consumption associated greater likelihood opioid misuse among males females findings elucidate genetic contributions misusing opioids showing genetics cannabis alcohol consumption associated lifetime opioid misuse among young adults though replication findings needed