Siriwan Suebnukarn, Peter Haddawy
A Bayesian approach to generating tutorial hints in a collaborative medical problem-based learning system
Artificial intelligence in medicine
recurrent joint bleeds major cause morbidity severe hemophilia prophylaxis efmoroctocog alfa recombinant factor viii fc fusion protein rfviiifc demonstrated benefits beyond bleed control including joint health maintenance assess longterm efficacy safety rfviiifc prophylaxis severe hemophilia phase 3 pivotal alongkids along extension aspire studies longitudinal analysis included pooled data alongkids along aspire subgroup analyses investigated outcomes modified hemophilia joint health score hemophilia joint health score target joints subjects 4 5 years followup individualized prophylaxis ip highest annualized bleeding rate abr quartile year 1 ip overall rfviiifc consumption remained stable low abrs maintained median treatment duration 4234 years subjects alongkids along respectively median overall abr also remained low 1020 subjects ip 4 5 years sustained improvements modified hemophilia joint health score hemophilia joint health score demonstrated median followup 37 years subjects alongkids along 996 n 234100 n 9 evaluable baseline target joints resolved recurrence 95100 target joints ip subjects within highest abr quartile year 1 continued improvements observed median followup 43 years abr joint health without increased factor consumption inhibitors treatmentrelated serious adverse events reported previously treated subjects ages receiving longterm prophylaxis rfviiifc sustained clinical benefits including improved joint health low abr