Nicole Cockayne|Nick Glozier|Sharon L. Naismith|Helen Christensen|Bruce Neal|Ian B. Hickie
Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trial
University of Sydney|University of Sydney|University of Sydney|Australian National University|The George Institute for Global Health|University of Sydney
depression cardiovascular disease cvd risk factors cognitive impairment important causes disability poor health outcomes combination lead even worse prognosis internet webbased interventions shown deliver efficacious psychological intervention programs depression large scale yet published studies evaluated impact among patients coexisting physical conditions aims randomised controlled trial determine effects evidencebased internet intervention program depression depressive mood symptoms cognitive function treatment adherence patients risk cvdthis study internetbased doubleblind parallel group randomised controlled trial trial compare effectiveness online cognitive behavioural therapy online attention control placebo trial consist 12week intervention phase 40week followup conducted urban rural new south wales australia recruit communitybased sample adults aged 45 75 years recruitment intervention cognitive testing followup data collection internetbased automated primary outcome change severity depressive symptoms baseline threemonths secondary outcomes changes cognitive function adherence treatment cvd baseline three six 12monthsprior studies depression amongst patients cvd targeted previous vascular events major depression potential intervening earlier disease states appears significant potential yet tested scalable psychological programs using webbased interventions could deliver care large numbers cost effective way efficacy proved study determine effects webbased intervention depressive symptoms adherence treatment among patients risk cvd addition also precisely reliably define effects intervention upon aspects cognitive function likely affected early risk individuals using sensitive responsive measuresaustralian new zealand clinical trials registry anzctr actrn12610000085077