Frederick J A Torlot|Mark McPhail|Simon D. Taylor?Robinson
Meta?analysis: the diagnostic accuracy of critical flicker frequency in minimal hepatic encephalopathy
Imperial College London|St Mary's Hospital|St Mary's Hospital|Imperial College London|St Mary's Hospital|Imperial College London
minimal hepatic encephalopathy mhe reduces quality life increases risk road traffic incidents predicts progression overt hepatic encephalopathy death current psychometrybased diagnostic methods effective timeconsuming universal gold standard test yet agreed upon critical flicker frequency cff proposed languageindependent diagnostic tool mhe accuracy yet confirmedto assess diagnostic accuracy cff mhe performing systematic review metaanalysis studies report diagnostic accuracy testa systematic literature search performed locate publications reporting diagnostic accuracy cff mhe data extracted 2 2 tables calculated reported accuracy data collated data metaanalysed sensitivity specificity diagnostic odds ratio dor summary receiver operator curve sroc analysis prespecified subgroup analysis metaregression also performednine studies data 622 patients included summary sensitivity 61 95 ci 5567 specificity 79 95 ci 7583 dor 109 95 ci 42283 symmetrical sroc gave area receiver operator curve 084 se 006 heterogeneity dor 74critical flicker frequency high specificity moderate sensitivity diagnosing minimal hepatic encephalopathy given advantages language independence simple perform interpret suggest use critical flicker frequency adjunct replacement psychometric testing