Canice Chukwudi Anyachukwu, Confidence Chinemerem Amarah, Blessing Chiagozikam Atueyi, Ifeanyi Anthony, Martins Nweke, Ukachukwu Abaraogu
Effectiveness of Back care education Programme among school children: a systematic review of randomized controlled trials
BMC pediatrics
disturbances maternal placental fetal metabolism associated developmental outcomes associations maternal placental fetal metabolism subsequent neurodevelopmental outcomes child understudied investigate metabolic associations within maternalplacentalfetal unit subsequent neurodevelopmental outcomes younger siblings children autism spectrum disorder asd cohort study conducted within subset markers autism risk babies learning early signs marbles cohort marbles prospective birth cohort younger siblings children asd assessed neurodevelopmental outcomes approximately age 36 months participants marbles recruited uc davis mind institute subset marbles cohort included younger siblings born 2009 2015 maternal third trimester serum placental tissue umbilical cord serum samples collected participants pregnancies least 2 sample types included analysis data analysis conducted march 1 2023 march 15 2024 quantitative metabolomics analysis conducted maternal third trimester serum well placental tissue umbilical cord serum collected delivery using autism diagnostic observation schedule mullen scales early learning outcomes classified asd nontypical development nontd typical development td analysis included 100 maternal serum samples 141 placental samples 124 umbilical cord serum samples 152 pregnancies median iqr maternal age 346 308383 years median iqr gestational age 390 386397 weeks 87 572 male infants evidence maternal third trimester serum metabolome significantly associated metabolomes placental cord serum metabolomes highly correlated first latent variate pair r2 075 p 001 variate scores tissue significantly associated reduced risk nontd placenta relative risk rr 013 95 ci 002071 cord rr 013 95 ci 003070 asd placenta rr 109 95 ci 042281 cord rr 063 95 ci 023173 compared td reference group cohort study children high familial risk asd placental cord serum metabolism delivery highly correlated furthermore placental cord serum metabolic profiles associated risk nontd