Chiara Doneda, Barbara Scelsa, Paola Introvini, Maurizio Zavattoni, Simona Orcesi, Giuseppina Lombardi, Lorenza Pugni, Monica Fumagalli, Mariangela Rustico, Elena Vola, Filippo Arrigoni, Elisa Fabbri, Mario Tortora, Giana Izzo, Maurilio Genovese, Cecilia Parazzini, Beatrice Tassis, Andrea Ronchi, Carlo Pietrasanta, Fabio Triulzi, Andrea Righini
Congenital Cytomegalovirus Infection With Isolated "Minor" Lesions at Fetal Magnetic Resonance Imaging: Long-Term Neurological Outcome
Pediatric neurology
mitochondrial disease diagnosed increasing frequency although children mitochondrial disease often severe lifelimiting illnesses many survive adulthood however limited information impact mitochondrial disease healthcare utilization us across lifespan describe characteristics inpatient hospitalizations related mitochondrial disease us identify patientlevel clinical factors associated inhospital mortality estimate burden hospitalizations individual patients crosssectional longitudinal observational studies us hospitals individuals hospital discharges included triennial healthcare cost utilization project hcup kids inpatient database kid national inpatient sample nis 2012 crosssectional analysis individuals hospital discharges included hcup california state inpatient database 2007 2011 inclusive longitudinal analysis hospital discharge associated diagnosis mitochondrial disease total number rate hospitalizations individuals mitochondrial disease international classification diseases 9th revision clinical modification code 27787 disorder mitochondrial metabolism inhospital mortality 2012 approximately 3200 inpatient pediatric hospitalizations 19 per 100000 population 2000 inpatient adult hospitalizations 08 per 100000 population mitochondrial disease us associated direct medical costs 113million inhospital mortality rates 24 children 30 adults far exceeding population averages higher socioeconomic status associated diagnosis mitochondrial disease higher inhospital mortality 2007 2011 california 495 individuals least one admission diagnosis mitochondrial disease patients median 11 hospitalizations iqi 0622 per calendar year followup infants 2y hospitalized frequently age groups five years follow 99 participants hospitalization mitochondrial disease noted inhospital death hospitalizations pediatric adult mitochondrial diseases associated serious illnesses substantial costs significant patient time identification opportunities prevent shorten hospitalizations focus future studies