Sujuan Gao|Yinlong Jin|Frederick W. Unverzagt|Feng Ma|Kathleen Hall|Jill R. Murrell|Yibin Cheng|Jianzhao Shen|Bo Ying|Rongdi Ji|Janetta Matesan|Chaoke Liang|Hugh C. Hendrie
Trace Element Levels and Cognitive Function in Rural Elderly Chinese
Indiana University – Purdue University Indianapolis
background trace elements involved metabolic processes oxidationreduction reactions central nervous system could possible effect cognitive function relationship trace elements measured individual biological samples cognitive function elderly population investigated extensively methods participant population part large cohort study 2000 rural elderly chinese persons six cognitive assessment tests used evaluate cognitive function population composite score created represent global cognitive function trace element levels aluminum calcium cadmium copper iron lead zinc analyzed plasma samples 188 individuals randomly selected consented donating fasting blood analysis covariance models used assess association trace element composite cognitive score adjusting demographics medical history chronic diseases apolipoprotein e apoe genotype results three trace elementscalcium cadmium copperwere found significantly related composite cognitive score increasing plasma calcium level associated higher cognitive score p 0001 increasing cadmium copper contrast significantly associated lower composite score p 0044 p 0121 respectively trace elements show significant association composite cognitive score conclusions results suggest calcium cadmium copper may associated cognitive function elderly population