Stefan Buss, Lukas Ketter, Dana Brünink, Dominik Schwab, Steffen Klenner, Alexander Hepp, Jutta Kösters, Thomas J Schmidt, Rainer Pöttgen, Nikos L Doltsinis, Cristian A Strassert
Antiprotozoal Pt(II) Complexes as Luminophores Bearing Monodentate P/As/Sb-Based Donors: An X-ray Diffractometric, Photoluminescence, and 121Sb-Mössbauer Spectroscopic Study with TD-DFT-Guided Interpretation and Predictive Extrapolation toward Bi
Inorganic chemistry
evolving sarscov2 variants changing levels preexisting immunity require reevaluation antigendetecting rapid diagnostic test agrdt performance investigated possible associations agrdt sensitivity various potential influencing factors immunisation status viral variant symptomatic hospital employees observational study rtpcr agrdt symptomspecific data collected three sarscov2 test centres employees charituniversittsmedizin berlin hospital berlin germany employees reporting sarscov2like symptoms increased risk infection eg due contact infected person testing positive previous selfadministered agrdt seeking releasetesting return work least 7 days positive rtpcr test eligible combined testing rtpcr agrdt data individuals ongoing sarscov2 infection assessed rtpcr used analysis bayesian regression analyses done evaluate possible differences viral load agrdt sensitivity according viral variant immunisation status previous vaccination recovery infection using data first rtpcr positive samples infection comprehensive logistic regression analysis used investigate potential concomitant associations agrdt sensitivity level preexisting immunity time post symptom onset viral load gender age agrdt device agrdt performance also compared supernatants cell cultures infected omicron variant concern voc wildtype strain prevoc nov 30 2020 feb 11 2022 total 14 773 samples 7675 employees tested sarscov2 rtpcr agrdt found negative association immunisation status agrdt sensitivity symptomatic employees observed sensitivity 82 94 highest posterior density interval hpdi 7886 immunologically naive participants compared 73 6878 multiply immunised individuals ie least two vaccinations recoveries infection median log10 viral loads 702 iqr 583807 808 680889 respectively dominant viral variant changed several times study period prevoc period sensitivity 80 94 hpdi 7585 symptomatic participants alpha variant 82 7094 delta variant 75 6982 omicron variant 72 6579 waves concomitantly steep increase vaccination coverage dataset comparison agrdt performance cell culture supernatants found difference wildtype omicron viral variants basis findings data studies hypothesise observed reduction clinical agrdt sensitivity despite higher sarscov2 rna loads due shorter incubation times later study period resulting increased population immunity changes immune response dynamics caused later sarscov2 vocs berlin university alliance german ministry education research eu projects eu4health recover berlin institute health