Fatimata Ly
Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial
objective compare effectiveness oral ivermectin iv two different modalities topical benzyl benzoate bb treating scabies community settingmethods trial included patients aged 565 years scabies attended dermatology department institut dhygine sociale dakar senegalthe randomized open trial considered three treatments single application 125 bb 24 hours bb1 group two applications bb 24 hours bb2 group oral iv 150200 gkg iv groupthe primary endpoint disappearance skin lesions itching day 14if necessary treatment repeated patients evaluated curedresults analysed intentiontotreat basisa preplanned intermediate analysis carried bb1 bb2 iv groups recruited 68 48 65 patients respectivelyfindings day 14 33 patients 688 bb2 group cured versus 37 544 bb1 group 16 246 iv group p 10 6 bacterial superinfection occurred often iv group bb1 bb2 groups combined 28 versus 78 respectively p 0006at day 28 46 patients 958 bb2 group cured versus 52 765 bb1 group 28 431 iv group p 10 5 clear findings prompted early study cessationconclusion topical bb clearly effective oral iv treating scabies senegalese community