Katie M Queenan|Maria Stewart|Kristen N Smith|William Thomas|R. G. Fulcher|Joanne L. Slavin
Concentrated oat ?-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
University of Minnesota|University of Minnesota|University of Minnesota|University of Minnesota|University of Minnesota|University of Minnesota
soluble fibers lower serum lipids difficult incorporate products acceptable consumers investigated physiological effects concentrated oat betaglucan cardiovascular disease cvd endpoints human subjects also compared fermentability concentrated oat betaglucan inulin guar gum model intestinal fermentation systemseventyfive hypercholesterolemic men women randomly assigned one two treatments 6 gramsday concentrated oat betaglucan 6 gramsday dextrose control fasting blood samples collected baseline week 3 week 6 analyzed total cholesterol hdl cholesterol ldl cholesterol triglycerides glucose insulin homocysteine creactive protein crp estimate colonic fermentability 05 g concentrated oat betaglucan incubated batch model intestinal fermentation system using human fecal inoculum provide representative microflora fecal donors involved betaglucan feeding trial inulin guar gum also incubated separate serum bottles comparisonoat betaglucan produced significant reduction baseline total cholesterol 03 01 mmoll ldl cholesterol 03 01 mmoll reduction ldl cholesterol significantly greater control group p 003 concentrated oat betaglucan fermentable fiber produced total scfa acetate concentrations similar inulin guar gum concentrated oat betaglucan produced highest concentrations butyrate 4 8 12 hourssix grams concentrated oat betaglucan per day six weeks significantly reduced total ldl cholesterol subjects elevated cholesterol ldl cholesterol reduction greater change control group based model intestinal fermentation oat betaglucan fermentable producing higher amounts butyrate fibers thus practical dose betaglucan significantly lower serum lipids highrisk population may improve colon health