Inés María Iglesias Rodríguez, Sachio Miura, Takuya Maeda, Kazuo Imai, Chris Smith, Clara Vasquez Velasquez, Sumihisa Honda, Kenji Hirayama
Analysis of the Chagas disease situation in Japan: a cross sectional study and cost-effectiveness analysis of a Chagas disease screening program
The Lancet regional health. Western Pacific
characterize clinical aspects evaluate diagnostic opportunity identify factors associated mortality patients hospitalized tuberculosis tb retrospective study patients admitted tb regional hospital chile 2011 2019 142 tb events required hospitalization period 382 total cases risk groups identified significant increase patients diabetes mellitus pulmonary location frequent 711 followed disseminated forms 162 sensitivity microscopy smear cases pulmonary tb isolated combined 788 lower cases bronchoalveolar lavage 583 pcr occasionally applied 10 sensitivity 100 sputum samples use increased progressively reached positivity 33 6 18 cases cases negative sputum staining median time symptom onset diagnosis prolonged 9 weeks 325 regional events diagnosed hospital dose adjustments 221 corticosteroid use 25 treatment interruptions frequent 11 lethality reached 19 multivariate analysis shock associated fatal outcome case series diagnosis tb cases delayed scarcely diagnosed molecular methods highly concentrated hospital level required admission large percentage cases high casefatality rate