May A. Beydoun|Jordan Weiss|Hardeep K. Obhi|Hind A. Beydoun|Gregory A. Dore|Hailun Liang|Michele K. Evans|Alan B. Zonderman
Cytokines are associated with longitudinal changes in cognitive performance among urban adults
National Institute on Aging|National Institute on Aging|University of Pennsylvania|National Institute on Aging|Johns Hopkins University|National Institute on Aging|Johns Hopkins University|National Institute on Aging|National Institute on Aging
chronic systemic inflammation positively associated structural functional brain changes representing early markers alzheimers disease ad cognitive decline current study examined associations systemic inflammation cognitive performance among africanamericans whites urban adults participants selected healthy aging neighborhoods diversity across life span handls study 20042013 baseline age 3064 mean sd followup time 464 093 n 189222 k 1517 observationsparticipant cytokines known positively linked ad incidence among others tested crosssectional longitudinal cognitive function stratifying age group 50 vs 50 sex race series mixedeffects regression models conducted adjusting key confounders among key findings il1 positively associated faster rate decline test executive functioning among older adults age 50 11 249 089 p 0005 total population il6 linked faster decline test verbal memory 11 0011 0004 p 0009 among younger participants il18 linked poorer performance test attention baseline age 50 01 0007 00025 p 0004 though slower rate decline higher il18 detected test psychomotor speed older adults age 50 11 00010 00004 p 0008 finally among whites unlike among africanamericans il6 associated better baseline performance two tests verbal working memory cytokines shown associated agerelated cognitive decline among middleaged older urban adults age group racespecific manner longitudinal studies needed replicate findings mediation relevant biological psychosocial factors need studied well