Jianrong Shi, Rashid Njai, Eden Wells, Jim Collins, Melinda Wilkins, Carrie Dooyema, Julie Sinclair, Hongjiang Gao, Jeanette J Rainey
Knowledge, attitudes, and practices of nonpharmaceutical interventions following school dismissals during the 2009 Influenza A H1N1 pandemic in Michigan, United States
PloS one
effect growth velocity height weight early infancy metabolic endpoints endothelial function children born art neonatal infant childhood growth positively related blood pressure 9yearold ivficsi offspring growth childhood negatively associated endothelial function offspring pregnancies conceived art risk later cardiometabolic risk factors well established early growth related numerous later cardiometabolic risk factors high blood pressure concept known developmental origin health disease theory relation early growth later cardiometabolic risk profile studied mediumkids study prospective observational cohort study children born ivficsi treatment 131 children 481 males average age 94 years cardiometabolic outcomes assessed growth data birth age 9 years collected child welfare centers following cardiometabolic outcomes assessed blood pressure skinfolds lipid spectrum hair cortisone glucose insulin levels data maximum skin perfusion transdermal delivery acetylcholine measure endothelial function collectedgrowth charts obtained electronically child welfare centers offer free consultations vaccinations dutch children centers height weight recorded predefined ages growth defined zscore difference weight two time points multivariable linear regression analysis used model relation growth cardiometabolic outcomes following growth windows studied simultaneously model 01 month 13 months 36 months 611 months 1124 months 26 years model adjusted height growth intervals except 01 month multivariable linear regression analyses multiple growth windows positively associated blood pressure example growth 26 years significantly related systolic blood pressure b 413 p 0005 maximum skin perfusion acetylcholine negatively associated heightadjusted weight gain 2 6 years b 009 log scale p 003 several growth windows weight 13 months 36 months 611 months 1124 months 26 years positively linked total adiposity lipids glucose tolerance indices cortisone related growth study modest size observational nature include control group therefore cannot assess whether observed associations causal also possible analyze observations specific exacerbated art population ideally control group naturally conceived siblings ivficsi children simultaneously studied address limitation assess impact art procedure without influence parental subfertility characteristics results study contribute understanding reported increased risk hypertension art offspring speculate early accelerated growth may involved reported increased risk hypertension art offspring endothelial dysfunction possible underlying mechanism however additional research mechanisms involved required study financially supported march dimes grant number 6fy13153 sponsor study role study design data collection data analysis data interpretation writing paper authors conflict interest declare ntr4220