Beate Peter|Wendy H. Raskind|Mark Matsushita|Mark Lisowski|Tiffany Vu|Virginia W. Berninger|Ellen M. Wijsman|Zoran Brkanac
Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample
University of Washington|University of Washington|University of Washington|University of Washington|University of Washington|University of Washington|University of Washington|University of Washington
two functionally related genes foxp2 cntnap2 influence language abilities families rare syndromic common nonsyndromic forms impaired language respectively investigated whether genes associated component phenotypes dyslexia measures sequential motor ability quantitative transmission disequilibrium testing qtdt linear association modeling used evaluate associations measures phonological memory nonword repetition nwr expressive language sentence repetition reading real word reading efficiency rwre word attack watt timed sequential motor activities rapid alternating place articulation rapa finger succession dominant hand fsd 188 family trios child dyslexia consistent prior study language impairment qtdt dyslexia showed evidence cntnap2 single nucleotide polymorphism snp association nwr foxp2 provide first evidence snp association component phenotypes dyslexia specifically nwr rwre watt addition foxp2 snp associations rapa fsd observed results confirm role cntnap2 nwr dyslexia sample motivate new questions effects foxp2 neurodevelopmental disorders