Jordan A McDonald, Alejandra Rincón, Rosny Daniel, Patricia S O'Sullivan, Karen E Hauer
"It's Time to Do It, to Make It a Major Part of Medicine": Faculty Experience With a Shift Toward an Antioppressive Medical School Curriculum
Academic medicine : journal of the Association of American Medical Colleges
improving safe effective access ketamine therapy high priority given growing burden mental illness telehealthsupported administration sublingual ketamine explored toward goal longitudinal study moderatelytoseverely depressed patients received four doses ketamine home four weeks within supportive digital health context treatment structured resemble methods therapeutic psychedelic trials patients receiving second course treatment also examined symptoms assessed using patient health questionnaire phq9 depression conducted preregistered machine learning symptom network analyses investigate outcomes osfiov2rpx sample 11441 patients analyzed demonstrating modal antidepressant response nonsevere n 6384 558 severe n 2070 181 baseline depression levels adverse events detected 3048 participants predominantly neurologic psychiatric nature second course treatment helped extend improvements patients responded favorably initial treatment improvement strongly predicted lower depression scores age baseline symptoms depressed mood anhedonia sustained depression despite ongoing treatment study limited absence comparison control groups lack fixeddose procedure ketamine administration athome telehealthsupported ketamine administration largely safe welltolerated associated improvement patients depression strategies combining psychedelicoriented therapies rigorous telehealth models explored may uniquely address barriers mental health treatment