Luiz Felipe Nevola Teixeira, Fabio Sandrin, Ruy Fernando Kuenzer Caetano da Silva, Francesco Petrella, Luca Bertolaccini, Maria Claudia Simoncini, Lorenzo Spaggiari
The Incidence of Winged Scapula after Thoracic Cancer Surgery: A Prospective Cohort Study
The Thoracic and cardiovascular surgeon
optimal meropenem dosing regimens critically ill patients receiving continuous renal replacement therapy crrt based pharmacokinetic pharmacodynamic pd concepts well established study aimed 1 gather available published pharmacokinetic studies conducted septic patients receiving crrt 2 define optimal meropenem dosing regimens populations via monte carlo simulations used medical subject headings meropenem continuous renal replacement therapy pharmacokinetics related terms identify studies systematic review onecompartment pharmacokinetic model conducted predict meropenem levels initial 48 h therapy pd targets 40 free drug threshold 1 times minimum inhibitory concentration mic 40 ft gt mic 4 times mic 40 ft gt 4mic additional target free drug level 1 times mic 100 time ft gt mic dose achieved least 90 probability target attainment pta defined optimal dose twentyone articles included systematic review necessary pharmacokinetic parameters volume distribution crrt clearance cited 905 714 articles respectively none published studies reported completed necessary parameters regimen 750 mg q 8 h found optimal dose predilution continuous venovenous hemofiltration continuous venovenous hemodialysis modality using two effluent rates 25 35 mlkgh achieved pd target 40 ft gt 4mic none published studies showed necessary pharmacokinetic parameters pd target significantly contributed meropenem dosage regimens patients differing effluent rates types crrt shared similar dosing regimens clinical validation recommendation suggested