Stella E. Panos|A. C. Del Re|April D. Thames|Timothy J. Arentsen|Srushti Patel|Steven A. Castellon|Elyse J. Singer|Charles H. Hinkin
The impact of neurobehavioral features on medication adherence in HIV: Evidence from longitudinal models
Neurobehavioral Systems|VA Greater Los Angeles Healthcare System|Stanford University|VA Palo Alto Health Care System|Neurobehavioral Systems|VA Greater Los Angeles Healthcare System|Neurobehavioral Systems|VA Greater Los Angeles Healthcare System|Neurobehavioral Systems|VA Greater Los Angeles Healthcare System|Neurobehavioral Systems|VA Greater Los Angeles Healthcare System|University of California, Los Angeles|Neurobehavioral Systems|VA Greater Los Angeles Healthcare System
effective antiretroviral therapy led substantial improvements healthrelated outcomes among individuals hiv despite advances hiv pharmacotherapy suboptimal medication adherence remains significant barrier successful treatment although several factors associated medication adherence extant literature study assessing effects neurobehavioral features specific hiv limited moreover although growing body literature measuring medication adherence hiv prospectively employ advanced statistical methodologies suited handle advanced models multiple predictors would strengthen understanding medication adherence trajectories hiv study sought integrate traditionally assessed predictors medication adherence neurobehavioral features hiv longitudinal study medication adherence combined antiretroviral therapy cart current study used multilevel modeling examine wide arrangement categories factors demographic medication related psychosocial neurobehavioral medication adherence sample consisted 235 hiv individuals whose medication adherence monitored course six months using electronic monitoring devices controlling effects demographic medication psychosocial factors neurobehavioral features added predictive validity model final model simultaneously controlling effects predictors within categories age selfefficacy executive functioning apathy frequency stimulant use emerged unique individual predictors average medication adherence across 6month study selfefficacy irritability predicted changes medication adherence time adherence behavior multidetermined adequate assessment factors combined timely intervention appears warranted order boost adherence rates