Loren H Raun, Laura A Campos, Elizabeth Stevenson, Katherine B Ensor, Gwen Johnson, David Persse
Analyzing Who, When, and Where: Data for Better Targeting of Resources for School-Based Asthma Interventions
The Journal of school health
employed novel approach identify key loci harbor genes influencing lipoprotein metabolism approximately 2000 pedigreed baboons fed various diets differing levels fat cholesterol study 126 overlapping traits related ldl hdl metabolism normalized subjected genomewide linkage screening expected traits highly completely correlated exploited information correlated traits focusing genomic regions harboring quantitative trait loci qtl multiple traits reasoning influential genes would impact larger number traits study identified five major qtl clusters least two significant logarithm odds scores 47 two previously reported baboons one mapped baboon ortholog human chromosome 1p32p34 influenced concentrations ldlcholesterol basal highfat lowcholesterol diets novel qtl cluster mapped baboon ortholog human chromosome 12q1313q141 influenced ldl size properties highfat lowcholesterol highfat highcholesterol basal diets confirming value approach three qtl clusters replicated published linkage findings similar traits