Sophia Vijay|Prahlad Kumar|L. S. Chauhan|Balasangameshwara Hanumanthappa Vollepore|Unnikrishnan Pallikkara Kizhakkethil|Sumathi Govinda Rao
Risk Factors Associated with Default among New Smear Positive TB Patients Treated Under DOTS in India
National Tuberculosis Institute|National Tuberculosis Institute|Ministry of Health and Family Welfare|Bangalore Diabetes Centre|National Tuberculosis Institute
background poor treatment adherence leading risk drug resistance treatment failure relapse death persistent infectiousness remains impediment tuberculosis control programmes objective study identify predictors default among new smear positive tb patients registered treatment suggest possible interventions set right problems sustain enhance programme performance methodology principal findings twenty districts selected six states assigned six strata formed considering geographic sociocultural demographic setup area new smear positive patients registered treatment two consecutive quarters iii quarter 2004 iii quarter 2005 formed retrospective study cohort case control analysis done including defaulted patients cases equal number age sex matched patients completing treatment controls presence degree association default determinant factors computed univariate multivariate logistic regression analysis data collection patient interviews using pretested semi structured questionnaire review treatment related records information wide range socio demographic patient related factors obtained among 687 defaulted equal numbers patients completed group 389 540 patients respectively satisfactorily interviewed logistic regression analysis factors independently associated default alcoholism aor172 123244 illiteracy aor140 103192 commitments treatment aor322 11909 inadequate knowledge tb aor188135263 poor patient provider interaction aor172123244 lack support health staff aor193141264 instances missed doses aor256182357 side effects anti tb drugs aor255 187347 dissatisfaction services provided aor173 11426 conclusion majority risk factors default treatment provider oriented rectifiable appropriate interventions would help sustaining good programme performance