May A. Beydoun|Hind A. Beydoun|Ola S. Rostant|Gregory A. Dore|Marie Fanelli Kuczmarski|Michele K. Evans|Alan B. Zonderman
Thyroid hormones are associated with longitudinal cognitive change in an urban adult population
National Institute on Aging|Eastern Virginia Medical School|National Institute on Aging|National Institute on Aging|University of Delaware|National Institute on Aging|National Institute on Aging
recent evidence indicates thyroid hormones may closely linked cognition among adults investigated associations thyroid hormones longitudinal cognitive change within outside reference ranges stratifying sex race longitudinal study used data healthy aging neighborhoods diversity across lifespan study set baltimore city md 20042013 adults aged 3064 years baseline visit length followup visits 1 2 ranging 1 8 years mean standard deviation 464 093 final analytic sample sizes ranged 1486 1602 participants 1617 visits per participant total visits 24962757 depending cognitive test eleven cognitive test scores spanning domains learning memory language verbal attention visuospatial andor visuoconstruction psychomotor speed executive function mental status used mixedeffects regression models conducted interacting time followup several thyroid exposures whites performed better african americans 4 cognitive test scores 11 declining significantly time importantly reference range thyroid stimulating hormone vs reference range thyroid stimulating hormone reference range tsharr linked faster rates decline digits span backwards test reflecting working memory tsharr time standard error 014 005 p 0006 clockcommand test visuospatial andor visuoconstruction abilities tsharr time standard error 010 004 p 0004 latter finding replicated comparing normal thyroid function subclinical hypothyroidism withinreference ranges higher thyroid stimulating hormone related faster decline clockcommand test scores women sum higher baseline thyroid stimulating hormone associated faster cognitive decline overtime among urban us adults specifically domains working memory visuospatial andor visuoconstruction abilities