Su Lin Lim|Jolyn Johal|Kai Wen Ong|Chad Yixian Han|Yiong Huak Chan|Yin Mei Lee|Wai Mun Loo
Lifestyle Intervention Enabled by Mobile Technology on Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial
National University Health System|National University Hospital|National University Health System|National University Hospital|National University Health System|National University Hospital|National University Health System|National University Hospital|National University of Singapore|National University Health System|National University Hospital|National University Health System|National University Hospital
background prevalence nonalcoholic fatty liver disease nafld reaches 30 asian adult population higher prevalence obese patients weight reduction typically recommended patients high risk diagnosed nafld challenge achieve objective aimed evaluate effect lifestyle intervention mobile app weight loss nafld patients methods prospective randomized controlled trial included 108 adults nafld confirmed steatosis ultrasound body mass index 23 kgm2 recruited fatty liver outpatient clinic patients randomly allocated either control group n53 receiving standard care consisting dietary lifestyle advice trained nurse intervention group n55 utilizing nutritionist buddy nbuddy mobile app addition receiving dietary lifestyle advice dietitian body weight alanine aminotransferase alt aspartate aminotransferase ast waist circumference blood pressure measured baseline 3 6 months intentiontotreat perprotocol analyses used statistical comparisons results intervention group 5fold higher likelihood relative risk 52 p003 95 ci 18154 achieving 5 weight loss compared control group 6 months intervention group also showed greater reductions weight mean 32 sd 41 kg vs mean 05 sd 29 kg plt001 waist circumference mean 29 sd 50 cm vs mean 07 sd 44 cm plt001 systolic blood pressure mean 124 sd 148 mmhg vs mean 24 sd 124 mmhg p003 diastolic blood pressure mean 68 sd 89 mmhg vs mean 09 sd 100 mmhg p001 alt mean 335 sd 404 iul vs mean 115 sd 352 iul p004 ast mean 174 sd 275 ul vs mean 74 sd 176 iul p03 6 months conclusions lifestyle intervention enabled mobile app effective improving anthropometric indices liver enzymes patients nafld treatment modality potential extended larger population scale trial registration australian new zealand clinical trials registry actrn12617001001381 httpstinyurlcomw9xnfmp