Madisyn L Cox, David Z Allen, Megan M Rodriguez, Jackson C Green, Joshua J Kain
An Analysis of Global Surgery Opportunities in American Otolaryngology Residency Programs
The Laryngoscope
mothertochild transmission hiv1 mtct remains major route hivtransmission among pediatric populations africa though prevention mtct pmtct highpriority country data mtct burdens cameroon remains fragmented sought assess pooled mtct rate riskfactors characterize viral reservoirs infectedchildren cameroon relevant observational cohort crosssectional studies conducted cameroon searched pubmed african journals online google scholar sciencedirect academic medical education databases heterogeneity publication bias respectively assessed i2 statistic eggerfunnel plot test metaanalysis performed using random effects model mtct rate 5 considered high review registered prospero database crd42021224497 included total 29 studies analyzed 46 684 children born hivpositive mothers overall rate mtct 700 95 ci 607851 according regions highest burden adamaouaregion 1751 95 ci14212107 one study found pmtct optionb resulted 25 reduction mtct 897 95 ci 871924 without optionb versus 288 95 ci 503934 optionb regarding riskfactors mtct significantly associated absence pmtctinterventions children or540 95 ci 2581127 mothers 359 95 ci 215599 regarding viral reservoirs proviral dna mean 334105 log10ml observed among 557 children archived hiv drug resistance mutations identified proviral dna marker among 2179 infectedchildren spite dropdown mtct following optionb implementation mtct remains high cameroon substantial disparities across regions thus era optionb achieving mtct elimination requires interventions northerncameroon variation proviral load infectedchildren underlines relevance characterizing viral reservoirs possible infection control tropical settings