Eugenia Lin, Tom J Crijns, David Ring, Prakash Jayakumar
Imposter Syndrome Among Surgeons Is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving
Clinical orthopaedics and related research
lysine acetylation primarily investigated context transcriptional regulation role acetylation mediating cellular responses emerged multiple studies described global lysine acetylation profiles particular biological states none date investigated temporal dynamics regulating cellular response perturbation reasoning lysine acetylation may altered response growth factors implemented quantitative mass spectrometrybased proteomics investigate temporal dynamics lysine acetylation response growth factor stimulation cultured carcinoma cell lines found lysine acetylation changed rapidly response activation several different receptor tyrosine kinases respective ligands uncover effects lysine acetylation dynamics tyrosine phosphorylation signaling networks cells treated hdac inhibitor shortterm pharmacological inhibition histone deacetylase activity modulated signaling networks involving phosphorylated tyrosine thereby altered response receptor tyrosine kinase activation result highlights interconnectivity lysine acetylation tyrosine phosphorylation signaling networks suggests hdac inhibition may influence cellular responses affecting types posttranslational modifications