Marietta Orlowski, Miryoung Lee, William Spears, Roopsi Narayan, Rebecca S Pobocik, Julie Kennel, Erin Krafka, Susan Patton
Patterns in Vegetable Consumption: Implications for Tailored School Meal Interventions
The Journal of school health
leverage advancements genomewide association studies gwas quantitative trait loci qtl mapping traits molecular phenotypes gain mechanistic understanding genetic regulation biological researchers often investigate expression qtls eqtls colocalize qtl gwas peaks research inspired 2 studies one aims identify causal single nucleotide polymorphisms responsible phenotypic variation whose effects explained impacts transcriptomic level maize study mouse focuses uncovering cisdriver genes induce phenotypic changes regulating transregulated genes studies formulated mediation problems potentially highdimensional exposures confounders mediators seek estimate overall indirect effect ie exposure paper propose meddic novel procedure estimate overall ie based differenceincoefficients approach simulation studies find meddic offers valid inference ie higher power shorter confidence intervals faster computing time competing methods apply meddic 2 aforementioned motivating datasets find meddic yields reproducible outputs across analysis closely related traits results supported external biological evidence code additional information available github page httpsgithubcomqizhangstatmeddic