Begoña Díaz|Florian Hintz|Stefan J. Kiebel|Katharina von Kriegstein
Dysfunction of the auditory thalamus in developmental dyslexia
Max Planck Institute for Human Cognitive and Brain Sciences
developmental dyslexia severe persistent reading spelling impairment characterized difficulties processing speech sounds ie phonemes test hypothesis phonological difficulties associated dysfunction auditory sensory thalamus medial geniculate body mgb using functional mri found dyslexic adults mgb responded abnormally task required attending phonemes compared speech features structure auditory pathway showed distinct functional neural patterns two tasks dyslexic control participants furthermore mgb activity correlated dyslexia diagnostic scores indicating task modulation mgb critical performance dyslexics results suggest deficits dyslexia associated failure neural mechanism dynamically tunes mgb according predictions cortical areas optimize speech processing view taskrelated mgb dysfunction dyslexics potential reconcile influential theories dyslexia within predictive coding framework brain function