Marta S Palmeirim, Yara C Baxter, Mariana Silveira, Rafael V Maggion, Beatriz Aquino, Álvaro Avezum, Jasmina Saric, Louise Morgan, Luciano F Drager, Luiz A Bortolotto, Suely Miya S Rollemberg, Marcia M C de Lima, Edmir P R Albuquerque, Olivia Jones, Peter Steinmann, Theresa Reiker, Johannes Boch
Situational analysis of hypertension management at primary health care level in São Paulo, Brazil: population, healthcare professional and health system perspectives
BMC health services research
crosssectional definitions successful cognitive aging widely utilized longitudinal measurements identify people decline performed study contrast maintenance declining trajectories including clinical conversion included baseline cognitively unimpaired alzheimers disease neuroimaging initiative participants 3 cognitive testing sessions n 539 followup 61 35 years calculated slopes episodic memory composite mem classify two groups maintainers slope 0 decliners slope 0 within decliners examined subgroup individuals became clinically impaired followup groups compared baseline characteristics cognitive performance well crosssectional longitudinal alzheimer disease ad biomarker measures betaamyloid tau hippocampal volume fortyone percent n 221 cohort mem maintainers 33 n 105 decliners converted clinical impairment followup compared superior baseline scores maintainers lower education likely male maintainers decliners differ baseline mem scores maintainers higher nonmem cognitive scores maintainers lower baseline global lower tau pathology larger hippocampal volumes decliners even removing converters differences rates change ad biomarkers cognitive trajectory groups except higher rate hippocampal atrophy clinical converters compared maintainers using longitudinal data define cognitive trajectory groups reduces education sex bias reveals prognostic importance early onset accumulation ad pathology ann neurol 2024