Anja Soldan|Corinne Pettigrew|Yi Lu|Mei?Cheng Wang|Ola A. Selnes|Marilyn Albert|Timothy Brown|J. Tilak Ratnanather|Laurent Younes|Michael I. Miller
Relationship of medial temporal lobe atrophy, <scp>APOE</scp> genotype, and cognitive reserve in preclinical <scp>A</scp>lzheimer's disease
Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University|Johns Hopkins University
abstract study evaluated utility baseline longitudinal magnetic resonance imaging mri measures medial temporal lobe brain regions collected participants cognitively normal largely middle age mean age 57 years predict time onset clinical symptoms associated mild cognitive impairment mci furthermore examined whether relationship mri measures clinical symptom onset modified apolipoprotein e apoe genotype level cognitive reserve cr mri scans measures cr obtained baseline 245 participants followed 18 years mean followup 11 years composite score based reading vocabulary years education used index cr cox regression models showed lower baseline volume right hippocampus smaller baseline thickness right entorhinal cortex predicted time symptom onset independently cr apoe4 genotype also predicted onset symptoms atrophy rates bilateral entorhinal cortex amygdala volumes also associated time symptom onset independent cr apoe genotype baseline volume one measure left entorhinal cortex baseline volume interacted cr smaller volumes predicted symptom onset individuals lower cr results suggest mri measures medial temporal atrophy apoe4 genotype protective effects higher cr predict time onset symptoms associated mci largely independent additive manner preclinical phase alzheimers disease hum brain mapp 3628262841 2015 2015 wiley periodicals inc