Alya Isam Elgamri, Azza Tagelsir Ahmed, Omer Elfatih Haj-Siddig, Judith R Chin
Infant oral mutilation (IOM) related to traditional practices among inner city pre-school children in Sudan
African health sciences
schizophrenia affects 1 global population addition complex etiology linking illness genetic environmental neurobiological factors dynamic experiences associated disease experiences delusions hallucinations disorganized thinking abnormal behaviors limit neurological consensuses regarding mechanisms underlying disease study recruited 72 patients schizophrenia 74 healthy individuals matched age sex investigate structural brain changes may serve prognostic biomarkers indicating evidence neural dysfunction underlying schizophrenia subsequent cognitive behavioral deficits used voxelbased morphometry vbm determine changes three tissue structures gray matter gm white matter wm cerebrospinal fluid csf image processing statistical analysis used statistical parametric mapping spm results show patients schizophrenia exhibited significant volume reduction gm wm particular gm volume reductions evident frontal temporal limbic parietal lobe similarly wm volume reductions predominantly frontal temporal limbic lobe addition patients schizophrenia demonstrated significant increase csf volume left third lateral ventricle regions vbm study supports existing research showing schizophrenia associated alterations brain structure including gray white matter cerebrospinal fluid volume findings provide insights neurobiology schizophrenia may inform development effective diagnostic therapeutic approaches