Karen Sliwa|M. Carrington|A. Becker|Friedrich Thienemann|Mpiko Ntsekhe|Simon Stewart
Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort
Chris Hani Baragwanath Hospital|University of the Witwatersrand|Groote Schuur Hospital|University of Cape Town|Chris Hani Baragwanath Hospital|University of the Witwatersrand|Baker Heart and Diabetes Institute|Chris Hani Baragwanath Hospital|University of the Witwatersrand|Charité - Universitätsmedizin Berlin|Groote Schuur Hospital|University of Cape Town|Groote Schuur Hospital|University of Cape Town|University of Cape Town|Chris Hani Baragwanath Hospital|University of the Witwatersrand|Baker Heart and Diabetes Institute
contemporary impact human immunodeficiency virus hivacquired immunodeficiency syndrome aids epidemic heart disease south africa 5 million people affected unknown heart soweto study provides unique opportunity identify contribution cardiac manifestations epidemic de novo presentations heart disease urban african community epidemiological transitionchris hani baragwanath hospital services 1 million people living soweto south africa prospective clinical registry captured data de novo cases heart disease presenting cardiology unit 200608 describe cases hivaids concurrently diagnosed overall 518 5328 de novo cases heart disease identified hivpositive 97 54 prescribed highly active antiretroviral therapies presentation women 62 africans 97 predominated women significantly younger men 38 13 vs 42 13 years p 0002 common primary diagnosis attributable hivaids hivrelated cardiomyopathy 196 cases 38 prescribed antiretroviral therapy 127196 vs 147322 odds ratio 285 95 confidence interval 181388 higher viral loads median 110 000 interquartile range 26 000510 000 vs 19 000 320087 000 p 0018 lower cd4 count median 180 71315 vs 211 96391 p 0019 rest additional 128 cases 25 diagnosed pericarditispericardial effusion range concurrent diagnoses evident including 42 cases 81 hivrelated pulmonary arterial hypertension 14 581 cases coronary artery disease cad 24 mean age 41 13 years confirmed hivpositivecardiac manifestations hivaids identified within cohort relatively infrequent hivrelated cardiomyopathy pericardial disease remain important targets early detection treatment setting hivrelated cases cad remain historically low levels