Roberto Giorgini, Fernando Maestu, Fernandes Margarida Sara, Massimiliano Pastore, Maria Abellan, Andrea Quattrone, Sara Caparello, Aldo Quattrone, Maria Grazia Vaccaro
Measurement invariance across countries of the Test of Memory Strategies (TMS): A contribution to the cross-national validity study
Acta psychologica
dendritic cells dcs antigen presenting cells serve passage innate acquired immunity aspergillosis major lethal condition immunocompromised patients caused adaptable saprophytic fungus aspergillus fumigatus healthy human immune system capable ward fumigatus infections however immunedeficient patients highly vulnerable invasive aspergillosis fumigatus persist infection due ability survive immune response human dcs therefore study metabolism specific context infection may allow us gain insight adaptation strategies pathogen immune cells established metabolic model fumigatus central metabolism infection dcs calculated metabolic pathway elementary modes ems transcriptome data used identify pathways activated fumigatus challenged dcs particular amino acid metabolic pathways alternative carbon metabolic pathways stress regulating enzymes found active metabolic flux modeling identified active enzymes alcohol dehydrogenase inositol oxygenase gtp cyclohydrolase participating different stress responses fumigatus validated qrtpcr rna extracted different conditions dcs outlined activation metabolic pathways response confrontation fumigatus found fatty acid metabolism plays crucial role along metabolic changes gene expression data analysis illuminate additional regulatory pathways activated dcs apart interleukin regulation particular tolllike receptor signaling nodlike receptor signaling rigilike receptor signaling active pathways moreover identified subnetworks several novel key regulators ubc egfr cul3 dcs activated response fumigatus conclusion analyze metabolic regulatory responses fumigatus dcs confronted