Samantha Lau|Xingrong Lu|Lyn Balsamo|Meenakshi Devidas|Naomi Winick|Stephen P. Hunger|William L. Carroll|Linda C. Stork|Kelly W. Maloney|Nina S. Kadan?Lottick
Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report
Yale University|University of Florida|Yale University|University of Florida|The University of Texas Southwestern Medical Center|Children's Hospital Colorado|University of Colorado Denver|New York University|Oregon Health & Science University|Children's Hospital Colorado|University of Colorado Denver|Yale University|Yale Cancer Center
background despite higher cure rates childhood acute lymphoblastic leukemia may continue result considerable family strain sought measure incidence divorce reduced career opportunities changes work hours home relocation changes family planning one year diagnosis ii identify family patient factors associated events procedure conducted prospective cohort study 159 children average riskall enrolled treated cog protocol aall0331 31 selected sites eligibility criteria included age 2 years english spanish comprehension parents completed surveys three time points first 12 months therapy results parents significantly increased risk loss employment 46 vs 91 p 0001 peers nationally 13 divorcedseparated 27 relocated homes 22 decided children 51 declined occupational opportunities 68 decreased work hours adjusted analyses relocation correlated less maternal education 427 95 ci 1431282 declining parental opportunities associated family income lt50000 425 95 ci 1501202 child lt5 years old 421 95 ci 1731025 deciding children correlated smaller family size 23 versus 45 362 95 ci 1101196 conclusion families experience high incidence major life changes first year treatment understanding burdens helps health care providers provide appropriate anticipatory guidance support unifying factor associated different family events ongoing followup planned measure longterm outcomes pediatr blood cancer 20146122772284 2014 wiley periodicals inc