Nicholas A. Badcock|Dorothy V. M. Bishop|Mervyn J. Hardiman|J Barry|Kate E. Watkins
Co-localisation of abnormal brain structure and function in specific language impairment
University of Oxford|University of Oxford|University of Oxford|University of Oxford|MRC Institute of Hearing Research|University of Nottingham|University of Oxford|John Radcliffe Hospital|Wellcome Centre for Integrative Neuroimaging
assessed relationship brain structure function 10 individuals specific language impairment sli compared six unaffected siblings 16 unrelated control participants typical language voxelbased morphometry indicated grey matter sli group relative controls increased left inferior frontal cortex decreased right caudate nucleus superior temporal cortex bilaterally unaffected siblings also showed reduced grey matter caudate nucleus relative controls auditory covert naming task sli group showed reduced activation left inferior frontal cortex right putamen superior temporal cortex bilaterally despite spatially coincident structural functional abnormalities frontal temporal areas relationships structure function regions different findings suggest multiple structural functional abnormalities sli differently associated receptive expressive language processing