Michael D Nicholson, Craig J Anderson, Duncan T Odom, Sarah J Aitken, Martin S Taylor
DNA lesion bypass and the stochastic dynamics of transcription-coupled repair
Proceedings of the National Academy of Sciences of the United States of America
floods frequent weatherrelated disaster causing significant health impacts worldwide limited studies examined longterm consequences flooding exposure flood data retrieved dartmouth flood observatory linked health data 499487 uk biobank participants calculate annual cumulative flooding exposure multiplied duration severity flood event summed values year conducted nested casecontrol analysis evaluate longterm effect flooding exposure allcause causespecific mortality case matched eight controls flooding exposure modelled using distributed lag nonlinear model capture nonlinear lagged effects risk allcause mortality increased 67 odds ratio 1067 95 confidence interval ci 10631071 every unit increase flood index confounders controlled mortality risk neurological mental diseases negligible current year strongest lag years 3 4 contrast risk mortality suicide strongest current year 1018 95 ci 10081028 attenuated lag year 5 participants higher levels education household income higher estimated risk death causes whereas risk suiciderelated mortality higher among participants obese lower household income engaged less physical activity nonmoderate alcohol consumers living deprived areas longterm exposure floods associated increased risk mortality health consequences flooding exposure would vary across different periods event different profiles vulnerable populations identified different causes death findings contribute better understanding longterm impacts flooding exposure