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Association of depression with disease severity in patients with chronic obstructive pulmonary disease
Lung
tuberculosis tb one biggest communicable causes mortality worldwide incidence uk continued fall since 2011 bradford retains one highest tb rates uk study aims examine local disease burden musculoskeletal msk tb analyzing common presenting factors within famously diverse population bradford observational study conducted using data bradford teaching hospitals tb database patients formal diagnosis msk tb january 2005 july 2017 patient data included demographic data including nationalitydate entry uk disease focus microbiology management strategies disease incidence calculated using population data office national statistics poisson confidence intervals calculated demonstrate extent statistical error disease incidence nationality also analyzed correlation sought using chisquared test january 2005 july 2017 109 cases msk tb diagnosed bradford mean incidence 165 per 100000 population per calendar year sd 075 total 38 cases required surgical intervention low rates antimicrobial resistance encountered low rate loss followup observed four patients 37 overall 945 patients n 103 successfully treated 67 patients n 73 reported country origin either india pakistan bangladesh ethnicities account around 25 local population bradford maintains high prevalence msk tb infection relative national data prevalence within local immigrant population remains grossly disproportionate typical associated factors hivhepatitis coinfection drug resistance modest prevalence dataset however local socioeconomic factors deprivation poverty appear germane suggested global literature advocate high degree suspicion treatment atypical infection area similar population factors ensure timely diagnosis cite article bone jt open 202235432440