Maki Jike|Osamu Itani|Norio Watanabe|Daniel J. Buysse|Yoshitaka Kaneita
Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression
Nihon University|Oita University|Kyoto University|University of Pittsburgh|Nihon University
examined doseresponse relationship long sleep duration health outcomes including mortality incidence diabetes mellitus hypertension cardiovascular diseases stroke coronary heart diseases obesity depression dyslipidemia collected data 5134036 participants 137 prospective cohort studies independent variable categorized participants baseline long sleep duration normal sleep duration risk ratios rrs mortality incident health conditions followup calculated metaanalyses adjusted data individual studies metaregression analyses performed investigate association outcome specific thresholds long sleep long sleep significantly associated mortality rr 139 95 ci 131147 incident diabetes mellitus 126 111143 cardiovascular disease 125 114137 stroke 146 126169 coronary heart disease 124 113137 obesity 108 102115 long sleep significantly related incident hypertension 101 095107 insufficient data available depression dyslipidemia metaregression analyses found statistically significant linear associations longer sleep duration increased mortality incident cardiovascular disease future studies address whether relationship long sleep health outcomes causal modifiable