Tessa Crume|Allison Shapiro|John T. Brinton|Deborah H. Glueck|Mercedes Martinez|Mary Kohn|Curtis S. Harrod|Jacob E. Friedman|Dana Dabelea
Maternal Fuels and Metabolic Measures During Pregnancy and Neonatal Body Composition: The Healthy Start Study
Colorado School of Public Health|Colorado School of Public Health|Colorado School of Public Health|Colorado School of Public Health|Colorado School of Public Health|University of Colorado Hospital|University of Colorado Denver|Colorado School of Public Health|University of Colorado Denver|Colorado School of Public Health
impact specific maternal fuels metabolic measures early late gestation neonatal body composition well defined determine circulating maternal glucose lipids insulin resistance first second halves pregnancy influence neonatal body composition prospective prebirth cohort enrolling pregnant women healthy start study conducted fasting maternal serum samples collected twice pregnancy measure glucose insulin hemoglobin a1c triglyceride total cholesterol highdensity lipoprotein free fatty acids neonatal body composition measured air displacement plethysmography observational epidemiology study pregnant women attending obstetric clinics university colorado anschutz medical center analysis includes 804 maternalneonate pairs strong positive linear relationship maternal estimated insulin resistance homeostasis model assessment insulin resistance first half pregnancy neonatal fat mass fm fm percentage fm detected independent prepregnancy body mass index bmi second half pregnancy positive linear relationships maternal glucose levels offspring fm fm observed independent prepregnancy bmi inverse relationship detected highdensity lipoprotein first half pregnancy fm independent prepregnancy bmi free fatty acid levels second half pregnancy positively associated higher birth weight independent prepregnancy bmi maternal insulin resistance first half pregnancy highly predictive neonatal fm whereas maternal glycemia even within normal range important driver neonatal adiposity later pregnancy independent prepregnancy bmi data provide additional insights potential maternal factors responsible fetal fat accretion early development adiposity