B. Lebwohl|Joseph A. Murray|Alberto Rubio?Tapia|P. H. R. Green|Jonas F. Ludvigsson
Predictors of persistent villous atrophy in coeliac disease: a population?based study
Karolinska Institutet|Columbia University|Karolinska University Hospital|Mayo Clinic in Arizona|Mayo Clinic in Arizona|Columbia University|Karolinska Institutet|Örebro University Hospital|Karolinska University Hospital
villous atrophy va intraepithelial lymphocytosis histological hallmark coeliac disease cd reported rates mucosal recovery variableto determine impact age demographic variables probability persistent va followup biopsywe identified patients va duodenal histology 28 swedish pathology departments years spanning 19692008 examined age gender calendar period duration disease educational attainment determine predictors persistent vaof 7648 patients cd underwent followup biopsy persistent va present 3317 43 95 ci 4244 effect age persistent va varied according time period among biopsied years spanning 20002008 prevalence persistent va 31 increasing age associated increasing rates persistent va 17 among younger 2 years compared 56 among 70 years contrast persistent va vary widely age earlier years multivariate analysis restricted calendar period 20002008 25 years cd diagnosis persistent va common among males 143 95 ci 107190 less common among patients higher educational attainment college degree vs 2 years high school 052 95 ci 035078the prevalence persistent villous atrophy changed time greater rates healing recent years social differences persistent villous atrophy suggest access andor education regarding glutenfree diet impact mucosal healing