Vanessa B. Sheppard|Darren Mays|Kenneth P. Tercyak|Thomas A. LaVeist
Medical Mistrust Influences Black Women’s Level of Engagement in BRCA1/2 Genetic Counseling and Testing
Georgetown University Medical Center|Georgetown University|Georgetown University Medical Center|Georgetown University|Georgetown University Medical Center|Georgetown University|Johns Hopkins University
clinical evidence supports value brca12 genetic counseling testing managing hereditary breast ovarian cancer risk however brca12 genetic counseling testing underutilized among black women reasons low use remain elusive examined potential influence sociocultural factors medical mistrust concerns genetic discrimination genetic counseling testing engagement sample 100 black women increased risk carrying brca12 mutation eligible participants fell 1 3 groups 1 healthy women least 1 firstdegree relative affected breast andor ovarian cancer 2 women diagnosed breast cancer age less equal 50 years 3 women diagnosed breast andor ovarian cancer age greater equal 50 years either 1 firstdegree relative 2 seconddegree relatives breast andor ovarian cancer participants recruited clinical community settings completed semistructured interview study variable relationships examined using bivariate tests multivariate regression analysis expected genetic counseling testing engagement among sample low 28 accounting sociodemographic factors selfefficacy 037 p 001 women higher medical mistrust lower genetic counseling testing engagement 026 p 01 communitylevel individual interventions needed improve utilization genetic counseling testing among underserved women along trust building patients providers strategies enhance womens personal confidence impact medical mistrust realization benefits personalized medicine minority populations examined future studies