Antoine Choufani, Rasseel Barakat
The Knowledge, Attitude, and Practice of Lebanese Mothers Toward Their Children's Oral Health: A Cross-Sectional Survey
Cureus
due timedependent effect specific risk factors dementia multidomain interventions based lifecourse model might achieve optimal preventive effects dementia purpose study investigate effectiveness multidomain interventions based lifecourse model modifiable risk factors dementia atrisk chinese older adults twoarm proofofconcept randomized controlled trial randomly assigned 96 communitydwelling atrisk adults aged 60 years older 11 ratio either 6month multidomain intervention group dementia literacy physical activity cognitive training social activity optional modules control group health education primary outcomes dementia risk score cognitive composite z score secondary outcomes included individual components dementia risk score protective risk factors cognitive composite z score global cognition memory executive function language social isolation loneliness social contact social participation dementia literacy prevention belief linear mixed models maximum likelihood estimation used calculate outcomes groups time primary analyses showed dementia risk score significantly lower p 0001 cognitive composite z score significantly higher p 0013 multidomain intervention group control group baseline characteristics modify effects multidomain interventions p value interaction 005 secondary outcomes statistically significant group time interactions observed protective p 0001 risk factors p 0049 well executive function p 0020 loneliness p 0029 dementia literacy p 0001 prevention belief p 0001 multidomain interventions based lifecourse model feasible potential reduce dementia risk improve cognitive function atrisk chinese older adults trial registered chinese clinical trials registry chictr2100053417