Josephine Barnes|Bradford C. Dickerson|Chris Frost|Lize C. Jiskoot|David A. Wolk|Wiesje M. van der Flier
Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
National Hospital for Neurology and Neurosurgery|University College London|Massachusetts General Hospital|Harvard University|London School of Hygiene & Tropical Medicine|Amsterdam Neuroscience|Erasmus MC|Penn Center for AIDS Research|University of Pennsylvania|Amsterdam Neuroscience
determining relationship age alzheimers disease ad presentation important improve understanding provide better patient serviceswe used ad patient data n 7815 national alzheimer coordinating center database multinomial logistic regression investigate presentation age first cognitivebehavioral symptomsthe odds nonmemory first cognitive symptom including impairment judgment problem solving language visuospatial function increased younger age p 001 tests compared apathywithdrawal odds depression behavioral symptoms increased younger age p 02 tests whereas odds psychosis behavioral symptom increased older age p 001 teststhere considerable heterogeneity first cognitivebehavioral symptoms experienced ad patients proportions symptoms change age patients experiencing increasing nonmemory cognitive symptoms behavioral symptoms younger ages