Anita van Zwieten|Germaine Wong|Marinella Ruospo|Suetonia C. Palmer|Maria Rosaria Barulli|Annalisa Iurillo|Valeria Saglimbene|Patrizia Natale|Letizia Gargano|Marco Murgo|Clement T. Loy|Rosanna Tortelli|Jonathan C. Craig|David W. Johnson|Marcello Tonelli|Jörgen Hegbrant|Charlotta Wollheim|Giancarlo Logroscino|Giovanni F.M. Strippoli
Prevalence and patterns of cognitive impairment in adult hemodialysis patients: the COGNITIVE-HD study
University of Sydney|Children's Hospital at Westmead|Westmead Hospital|University of Sydney|Children's Hospital at Westmead|Università degli Studi del Piemonte Orientale “Amedeo Avogadro”|University of Otago|Polytechnic University of Bari|University of Bari Aldo Moro|Polytechnic University of Bari|University of Bari Aldo Moro|University of Sydney|University of Sydney|Westmead Hospital|Polytechnic University of Bari|University of Bari Aldo Moro|University of Sydney|Children's Hospital at Westmead|Princess Alexandra Hospital|Translational Research Institute|University of Queensland|University of Calgary|Polytechnic University of Bari|University of Bari Aldo Moro|University of Sydney|Polytechnic University of Bari|University of Bari Aldo Moro
mounting evidence indicates increased risk cognitive impairment adults endstage kidney disease dialysis extent pattern deficits across spectrum cognitive domains uncertainwe conducted crosssectional study 676 adult hemodialysis patients 20 centers italy aiming evaluate prevalence patterns cognitive impairment across five domains learning memory complex attention executive function language perceptualmotor function assessed cognitive function using neuropsychological battery 10 tests calculated test domain zscores using population norms age ageeducation defined cognitive impairment zscore 15participants median age 709 years range 216941 262 388 women proportions impairment domain follows perceptualmotor function 315 150476 language 412 273662 executive function 417 281674 learning memory 422 269638 complex attention 488 329674 among 474 participants data domains 289 n 137 impaired domain 259 impaired single domain n 123 173 two n 82 139 three n 66 91 four n 43 49 n 23 five across patients patterns impairment combinations diversein conclusion cognitive impairment extremely common hemodialysis patients across numerous domains patients often experience multiple deficits simultaneously clinical care tailored meet needs patients different types cognitive impairment future research focus identifying risk factors cognitive decline