Nerilee Hing, Hannah Thorne, Lisa Lole, Kerry Sproston, Nicole Hodge, Matthew Rockloff
Getting addicted to it and losing a lot of money… it's just like a hole.' A grounded theory model of how social determinants shape adolescents' choices to not gamble
BMC public health
although contemporary randomized clinical trial led use wholepelvic radiation therapy wprt longterm data evaluating potential reduction mortality lacking addressed current study 2005 2015 350 men localized unfavorablerisk prostate cancer pc randomly assigned receive androgen deprivation therapy adt rt plus docetaxel versus adt rt treatment pelvic lymph nodes discretion treating physician multivariable cox fine grays regression analyses performed assess whether significant association existed radiation treatment volume allcause mortality acm pcspecific mortality pcsm respectively adjusting known pc prognostic factors comorbidity interaction term age categorized dichotomization 65 years enable clinical interpretation applicability results approximates median 66 years iqr 6170 radiation treatment volume included analysis median followup 1020 years iqr 7961141 89 men died 2543 42 died pc 4719 350 randomly assigned patients 88 2514 received wprt men younger 65 years wprt associated significantly lower acm risk adjusted hazard ratio ahr 033 95 ci 011 097 p 04 lower pcsm risk ahr 017 95 ci 002 135 p 09 adjusting covariates whereas case men 65 years older wprt potential reduce mortality younger men unfavorablerisk pc