Hamed Khalili|Ashwin N. Ananthakrishnan|Gauree G. Konijeti|Xiaoyun Liao|L M Higuchi|Charles S. Fuchs|Donna Spiegelman|James M. Richter|Joshua R. Korzenik|Andrew T. Chan
Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses' Health Study cohorts
Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Harvard University|Boston Children's Hospital|Harvard University|Dana-Farber Cancer Institute|Harvard University|Brigham and Women's Hospital|Harvard University|Massachusetts General Hospital|Harvard University|Brigham and Women's Hospital|Massachusetts General Hospital|Harvard University|Brigham and Women's Hospital
bobjectiveb examine association physical activity risk ulcerative colitis crohns disease bdesignb prospective cohort study bsettingb nurses health study nurses health study ii bparticipantsb 194 711 women enrolled nurses health study nurses health study ii provided data physical activity risk factors every two four years since 1984 nurses health study 1989 nurses health study ii followed 2010 bmain outcome measureb incident ulcerative colitis crohns disease bresultsb 3 421 972 person years followup documented 284 cases crohns disease 363 cases ulcerative colitis risk crohns disease inversely associated physical activity p trend 002 compared women lowest fifth physical activity multivariate adjusted hazard ratio crohns disease among women highest fifth physical activity 064 95 confidence interval 044 094 active women least 27 metabolic equivalent task met hours per week physical activity 44 reduction hazard ratio 056 95 confidence interval 037 084 risk developing crohns disease compared sedentary women lt3 met hwk physical activity associated risk ulcerative colitis p trend 046 absolute risk ulcerative colitis crohns disease among women highest fifth physical activity 8 6 events per 100 000 person years compared 11 16 events per 100 000 person years among women lowest fifth physical activity respectively age smoking body mass index cohort significantly modify association physical activity risk ulcerative colitis crohns disease p interaction gt035 bconclusionb two large prospective cohorts us women physical activity inversely associated risk crohns disease ulcerative colitis