Nancy Green|Deepa Manwani|Sérgio Matos|April L. Hicks|Luisa Soto|Yina Castillo|Karen Ireland|Yvonne Stennett|Sally E. Findley|Haomiao Jia|Arlene Smaldone
Randomized feasibility trial to improve hydroxyurea adherence in youth ages 10–18 years through community health workers: The HABIT study
Columbia University Irving Medical Center|Albert Einstein College of Medicine|Health Net|Health Net|Albert Einstein College of Medicine|Columbia University|Columbia University|Columbia University
abstract introduction main therapeutic intervention sickle cell disease scd hydroxyurea hu effect hu largely dosedependent induction fetal hemoglobin hbf poor hu adherence common among adolescents methods 6month twosite pilot intervention trial habit led culturally aligned community health workers chws chws performed support primarily home visits augmented tailored text message reminders dyads youth scd ages 1018 years parent enrolled customized hbf biomarker percentage decrease patients highest historical huinduced hbf personal best used qualify enrollment assess hu adherence two primary outcomes follows 1 intervention feasibility acceptability 2 hu adherence measured three ways monthly percentage improvement toward hbf personal best proportion days covered pdc hu selfreport results twentyeight dyads enrolled 89 retained feasibility acceptability excellent controlling group assignment month intervention intervention group improved percentage decrease personal best 23 per month months 04 p 030 similar improvement adherence demonstrated using pharmacy records selfreported adherence correlate dyads viewed chws supportive learning scd hu living scd making progress coordinated selfmanagement responsibility support daily hu habit parents youth appreciated text message hu reminders conclusions habit pilot intervention demonstrated feasibility acceptability promising effect toward improved medication adherence testing larger multisite intervention trial warranted