Yared Zewde, Atalay Alem, Susanne K Seeger
Magnitude and predictors of post-stroke cognitive impairment among Ethiopian stroke survivors: A facility-based cross-sectional study
Research square
advent structural magnetic resonance imaging smri end 20th century opened way toward deeper understanding neurophysiology psychiatric disorders substantiating regional structural abnormalities underlying group clinical conditions however despite abundant flourishing scientific research smri methodologies currently integrated daily diagnostic practice one reason behind failed translation may prevailing approach logical reasoning neuroimaging forward inference via frequentistbased statistics reasoning prevents clinicians obtaining information selectivity results therefore limited use regarding definition biomarkers refinement diagnostic processes recently another type inferential approach started emerge neuroimaging field reverse inference via bayesian statistics introduce key concepts approach particular emphasis clinical smri environment survey recent findings showing significant potential clinical translation clinical opportunities challenges developing reverse inferencebased neural markers psychiatry also discussed propose systematic sharing imaging data across human brain mapping community essential first step toward paradigmatic clinical shift conclude defined synergy forwardbased reversebased smri research illuminate current discussions diagnostic brain markers offering clarity key issues fostering new tailored diagnostic avenues