Rifat A Wahab, Mitva Patel, Carol McLaughlin, Kirti Kulkarni, Bronwyn Nair, Lisa Mullen, Charmi Vijapura
Breast Imaging Fellowship Consortium: Developing a Comprehensive Virtual Educational Platform for Breast Imaging Fellows
Journal of breast imaging
oocyte donors recipients perceive genetic link related transfer nuclear dna donors offspring whether donors recipients individuals attach great importance transmission genetic heritage since 945 would opt pronuclear transfer method preserve genetic link context oocyte donation since 1983 use oocyte donation increased worldwide performed france since late 1980s initially offered women premature ovarian insufficiency indications progressively expanded proposed many indications prevent transmission genetically inherited diseases resulted increase waiting time access oocyte donation due difficulty recruiting oocyte donors french art centres several articles discussed fairly distribute donor oocytes couples interviewed women general population record feelings oocyte donation either donor recipient importance given genetic link oocyte donors children born mitochondrial replacement therapy mrt technique originally developed women risk transmitting mitochondrial dna mutation recently mrt considered embryo arrest oocyte rejuvenation could help females reproduce genetic material transfer oocyte nucleus healthy donor oocyte cytoplasm conducted opinion survey january 2021 december 2021 1956 women completed questionnaire thirteen participants excluded analysis due incomplete responses questions consequently 1943 women included study specifically developed questionnaire study created distributed using dragn survey software questionnaire consisted 21 items presented alongside video created whiteboard animation software aim analyse whether certain factors age education level marital status number children use art pregnancy video viewing knowledge oocyte donation associated feelings towards oocyte donation using univariate conditional logistic regression model statistical method also used assess whether women would inclined consider oocyte donation pronuclear transfer technique rather whole oocyte donation parameters found statistically significant univariate analysis subsequently tested multivariate model using logistic regression women concerned biological genetic contribution donated oocyte 948 common reason womens reluctance donate oocytes unwillingness pass genetic material 333 nearly 70 women initially hesitant donate oocytes indicated would reconsider decision oocyte donation conducted using donated cytoplasm pronuclear transfer technique concomitantly 75 respondents mentioned would easier receive cytoplasm donation largest proportion population surveyed 945 expressed support legalization study substantial portion responses came individuals medical paramedical backgrounds potentially introducing recruitment bias among potential donors rate missing responses question regarding desire become oocyte donor 136 question becoming oocyte cytoplasm donor missing response rate 23 missing responses may introduce bias interpretation data study first demonstrate french population studied combination oocyte cytoplasm donation pronuclear transfer could offer promising approach enhance acceptance oocyte donation donor recipient external funding used study authors conflicts interest na