Maria M Remenyi
[Heinrich Wieleitner (1874-1931) and The Birth of Modern Mathematics-Science Communication and the Historiography of Mathematics in the Weimar Culture]
NTM
endometriosiss pathophysiology remains incompletely understood evidence pointing towards dysregulated immune response regulatory treg cells pivotal maintaining selftolerance may facilitate survival ectopic endometrial cells within abdominal cavity thereby contributing endometriosis development study aimed assess prevalence cd39cd73 suppressor treg cell subsets peripheral blood endometriosis patients research focuses pivotal role regulatory tcells tregs essential maintaining immune tolerance preventing autoimmune diseases casecontrol study conducted including 32 women diagnosed endometriosis 22 control subjects frequency peripheral blood cd39cd73 suppressor treg cells quantified using flow cytometry significant differences observed frequency cd3cd4cd25high cells median 101 interquartile range iqr 632183 vs 972 iqr 622198 cd3cd4cd25highcd39foxp3 cells 311 iqr 197440 vs 3055 iqr 185455 controls patients however significantly lower frequency cd3cd4cd25highcd39cd73 cells observed endometriosis group compared controls 198 iqr 00377317 vs 225 iqr 050408 p 00483 suggesting reduction systemic immune tolerance among patients finding highlights potential role cd39 cd73 expression treg cells biomarkers assessing disease severity progression furthermore elucidating mechanisms driving alterations may unveil new therapeutic strategies restore immune equilibrium mitigate endometriosis symptoms