Christie van Diggele, Stuart Lane, Chris Roberts
Student Interprofessional Facilitator Training (SIFT) program: building capacity in clinical education leadership
BMC medical education
osteoporosis op closely associated gut microbiota gm yet nature causal relationship remains elusive therefore study aims reverse causality gm op using population cohorts twosample mr tsmr analysis study conducted extensive genomewide association study gwas using publicly accessible summary statistics data gm op employing rigorous criteria p 1e5 identified independent genetic loci exhibited significant associations gm relative abundances instrumental variables ivs causal evaluation primarily carried using inverse varianceweighted ivw method supplemented additional analyses mregger weighted median simple mode weighted mode unveiled increased abundances family pasteurellaceae order pasteurellales genus ruminococcaceae ucg004 linked increased risk op conversely family oxalobacteraceae unknown family id1000006161 genus lachnospiraceae nk4a136 group unknown genus id1000006162 order nb1n associated reduced risk op ensure reliability findings conducted quality assessments cochranes q test leaveoneout analysis furthermore stability consistency results confirmed mregger intercept test mendelian randomization pleiotropy residual sum outlier mrpresso global test sensitivity analysis p 005 study reveals causal relationships 211 gm taxa op pinpointing specific gm taxa associated risk op research sheds light genetic mechanisms underlie gmmediated op opens promising avenues identifying valuable biomarkers potential therapeutic targets future op research study establishes substantial gmop link specific taxa identified offering biomarkers early detection tailored interventions improved patient education findings enhance op diagnosis prevention treatment promising effective individualized care inspiring future research