Tinisaie Biadigie Adane, Kelemu Zelalem Berhanu, Abatihun Alehegn Sewagegn
Infertile women of Ethiopia: Psychological challenges and coping strategies
Medicine
mode birth linked offspring health changes dna methylation dnam may represent potential mechanism however findings heterogeneous limited early infancy preregistered study examined whether mode birth vaginal birth compared elective emergency cesarean section affects dnam birth childhood adolescence whether effects modified postnatal care environment specifically breastfeeding motherinfant bonding using data 876 motherinfant dyads uk avon longitudinal study parents children examined differentially methylated cytosinephosphateguanine dinucleotides regions associated mode birth dnam quantified using illumina infinium human methylation 450 k beadchip cord blood birth peripheral blood 7 1517 years analyses controlled maternal age education smoking pregnancy child sex gestational week birth batch effects also examined interactions mode birth breastfeeding practices motherinfant bonding cord blood two cytosinephosphateguanine dinucleotides cg05230316 cg13230077 linked mode birth pfdr 050 dnam childhood adolescence statistically associated mode birth pfdr 050 breastfeeding motherinfant bonding moderators p 050 overall findings suggest mode birth may small effect cord blood dnam effects may persist later developmental stages postnatal influences considered investigation needed address study limitations psycinfo database record c 2024 apa rights reserved