Catherine F. Slattery|Jiaying Zhang|Ross W. Paterson|Alexander Foulkes|Amelia M. Carton|Kirsty Macpherson|Laura Mancini|David L. Thomas|Marc Modat|Nicolas Toussaint|David M. Cash|John S. Thornton|Susie M.D. Henley|Sebastian J. Crutch|Daniel C. Alexander|Sébastien Ourselin|Nick C. Fox|Hui Zhang|Jonathan M. Schott
ApoE influences regional white-matter axonal density loss in Alzheimer's disease
University College London|University College London|University College London|University College London|University College London|University College London|University College London|National Hospital for Neurology and Neurosurgery|University College London|University College London|University College London|University College London|University College London|National Hospital for Neurology and Neurosurgery|University College London|University College London|University College London|University College London|University College London|University College London|University College London
mechanisms underlying phenotypic heterogeneity young onset alzheimer disease yoad poorly understood used diffusion tensor imaging neurite orientation dispersion density imaging noddi tractbased spatial statistics investigate apolipoprotein apoe 4 modulation whitematter damage 37 patients yoad 22 59 apoe 4 positive 23 agematched controls correlation neurite density index ndi neuropsychological performance assessed 4 whitematter regions interest whitematter disruption widespread 4 individuals focal posterior predominant absence 4 allele noddi metrics indicate fractional anisotropy changes underpinned combinations axonal loss morphological change regional ndi parietooccipital white matter correlated visual object spatial perception battery performance right left p 002 performance nonverbal intelligence wasi matrices right p 004 noddi provides tissuespecific microstructural metrics whitematter tract damage yoad including ndi correlates focal cognitive deficits apoe4 status associated different patterns whitematter neurodegeneration