Shari S Rogal, Charles Jonassaint, LauraEllen Ashcraft, Janet Freburger, Vera Yakovchenko, Yasaswi Kislovskiy, Angela Phares, Gretchen Hershberger, David E Goodrich, Matthew Chinman
Getting To Implementation (GTI)-Teach: A seven-step approach for teaching the fundamentals of implementation science
Journal of clinical and translational science
organochlorine pesticides environmental persistence bioaccumulation potential gained significant attention study explores impact organochlorine pesticides mortality chronic diseases investigates link inflammatory states examines role antiinflammatory diets mitigating adverse reactions pesticides study 2847 participants used gas chromatography mass spectrometry measure organochlorine pesticide exposure nhanes data conventional statistical methodologies encompassing survival curves cox proportional hazards regression regression analysis restricted quadratic spline analysis employed investigate association pesticides mortality chronic ailments inflammation furthermore machine learning techniques comprising rf adaboost extratrees lightgbm bpnn leveraged evaluate impact pesticides chronic disease mortality prognostication organochlorine pesticides significantly positively correlated increased mortality p005 additionally pollutants linked incidence chronic diseases chronic kidney disease diabetes hypertension p 005 study utilizing various machine learning models also showed notable increase area curve incorporating organochlorine pesticide indicators model opposed excluding furthermore strong correlations observed serum creactive protein crp crp serum albumin ratio car concentrations substances demonstrating proinflammatory effects specific concentrations interestingly cutting dietary inflammation changes diet effectively reduced risk death high organochlorine pesticide exposure levels effect less noticeable low moderate exposure levels exposure organochlorine pesticides linked higher risk mortality likely due increased prevalence chronic diseases context inflammation played crucial role adopting antiinflammatory diet significantly reduced mortality risk associated pesticides