Anand Kumar
Protein Binding in Patients With Late-Life Depression
University of California, Los Angeles|University of Illinois at Chicago
depression identified risk factor prodrome dementia common neurobiological mechanisms may underlie clinical phenomenologic overlapto examine compare protein amyloid tau binding critical brain regions patients diagnosed latelife major depressive disorder mdd healthy control individuals using 216218ffluoroethylmethylamino2naphthylethylidene malononitrile 18ffddnp positron emission tomographya crosssection neuroimaging study using positron emission tomographyuniversity california los angeles patients samples comprised 20 patients diagnosed mdd 19 healthy control individuals comparable age sex educational level main outcome measure relative distribution volume regions interest used measure 18ffddnp binding study participantswhen compared controls 18ffddnp binding significantly higher overall posterior cingulate lateral temporal regions mdd groupthese findings suggest neuronal injury associated higher protein load critical brain regions might provide mechanism pathophysiologic manifestation mdd late life implications therapeutics depression elderly individuals