C P van Schayck, Maartje Willeboordse, Marije Oosterhof, Nina Bartelink, Patricia van Assema, Stef Kremers, Bjorn Winkens, Hans Savelberg, Maria Jansen, Manuela Joore, Anita C E Vreugdenhil
[Effects and costs of The Healthy Primary School of the Future]
Nederlands tijdschrift voor geneeskunde
evaluate association serum folate levels schizophrenia clinical characteristics patients russian sample ninetythree patients schizophrenia 60 healthy volunteers examined determination serum folate levels performed chemiluminescent immunoassay microparticles architect abbott lab sa symptoms schizophrenia assessed positive negative syndrome scale calgary schizophrenia depression scale snighthamilton anhedonia scale brief assessment cognition schizophrenia personal social performance scale scale therapy sideeffects assessment simpsonangus scales abnormal involuntary movements scale barnes akathisia rating scale statistical analysis performed using statistica 60 since data distribution different normal nonparametric criteria used patients significantly lower folate levels healthy controls p000053 mainly women p00025 time subgroups including healthy ones vast majority participants folate levels median 995 ngml lower quartile reference values patients folate levels inversely correlated severity negative symptoms directly correlated measures cognitive functions patients folate levels reference values differed patients greater severity total score negative symptoms p0023 marders factors negative symptoms p0046 disorganized thinking p0033 greater severity general side effects therapy p0021 measures cognitive functions except verbal memory smoking significant effect serum folate levels participants p0016 also inverse association folate levels selectivity antipsychotics p0035 severe folate deficiency inpatients outpatients p00063 results obtained russian sample association folate deficiency schizophrenia wide range clinical indicators including affecting prognosis schizophrenia indicate high relevance study topic introduction approaches augmentation antipsychotic therapy schizophrenia folates