Tiina Laatikainen|James Dunbar|Anna Chapman|Annamari Kilkkinen|Erkki Vartiainen|Sami Heistaro|Ben Philpot|Pilvikki Absetz|Stephen Bunker|Adrienne O’Neil|Prasuna Reddy|James D. Best|Edward Janus
Prevention of Type 2 Diabetes by lifestyle intervention in an Australian primary health care setting: Greater Green Triangle (GGT) Diabetes Prevention Project
Institute for Molecular Medicine Finland|Institute for Molecular Medicine Finland|University of Melbourne|St Vincent's Hospital
randomised controlled trials demonstrate 60 reduction type 2 diabetes incidence lifestyle modification programmes aim study determine whether programmes feasible primary health carean intervention study including 237 individuals 4075 years age moderate high risk developing type 2 diabetes structured group programme six 90 minute sessions delivered eight month period trained nurses australian primary health care 20042006 main outcome measures taken baseline three 12 months included weight height waist circumference fasting plasma glucose lipids plasma glucose two hours oral glucose challenge blood pressure measures psychological distress general health outcomes test differences baseline followup paired ttests wilcoxon rank sum tests performedat twelve months participants mean weight reduced 252 kg 95 confidence interval 185 319 waist circumference 417 cm 348 487 mean fasting glucose reduced 014 mmoll 007 020 plasma glucose two hours oral glucose challenge 058 mmoll 036 079 total cholesterol 029 mmoll 018 040 low density lipoprotein cholesterol 025 mmoll 016 034 triglycerides 015 mmoll 005 024 diastolic blood pressure 214 mmhg 094 333 significant improvements also found psychological measuresthis study provides evidence type 2 diabetes prevention programme using lifestyle intervention feasible primary health care settings reductions risk factors approaching observed clinical trials