Chen Qian, Jian-Hong Ye, Yi-Sang Lee
The effects of art design courses in higher vocational colleges based on C-STEAM
Frontiers in psychology
epha4 receptor epha4 tyrosine kinase important regulator central nervous system development synaptic plasticity mature brain relevance control normal behavior remains largely unexplored study first attempt obtain behavioral profile constitutive homozygous heterozygous epha4 knockout mice deficit locomotor habituation open field impairment spatial recognition ymaze reduced probability spatial spontaneous alternation tmaze identified homozygous epha4 mice heterozygo us epha4 mice appeared normal tests comparison wildtype wt controls multiple phenotypes observed epha4 mice might stem underlying deficit habituation learning reflecting elementary form nonassociative learning contrast pavlovian associative learning appeared unaffected epha4 disruption deficit motor coordination accelerating rotarod also demonstrated epha4 micea finding keeping presence abnormal gait epha4 micealthough able improve performance training evidence substantial changes major neurochemical markers various brain regions rich epha4 shown postmortem analysis excludes possibility major neurochemical compensation brain epha4 mice summary demonstrated first time behavioral significance epha4 disruption supporting investigation epha4 possible target behavioral interventions habituation deficits prominent