Ana Luiza Dallora, Ewa Kazimiera Andersson, Bruna Gregory Palm, Doris Bohman, Gunilla Björling, Ludmiła Marcinowicz, Louise Stjernberg, Peter Anderberg
Nursing Students' Attitudes Toward Technology: Multicenter Cross-Sectional Study
JMIR medical education
although mitraclip studied numerous trials evidence long term based original studies used original technique evidence synthesis review longterm comparative trials evaluating mitraclip searched pubmed database select longterm comparative trials mitraclip endpoint allcause mortality minimum followup one year included trials analyzed using ipdfromkm reconstruct individual patient data published kaplanmeier survival curves method reconstruct individual patient data kaplanmeier curves standard survival statistics used interpret longterm efficacy data survival benefit per patient estimated restricted mean survival time rmst six comparative studies mitraclip included 973 patients treated mitraclip six arms 717 medical therapy five arms 80 surgical repair replacement one arm main analysis outcomes observed patients treated mitraclip significantly better medical therapy hazard ratio allcause mortality 05276 95 confidence interval 04412 06309 p 0001 number patients treated surgery small make reliable comparisons median survival 304 months medical therapy versus reached two groups rmst 43931 33756 months mitraclip controls respectively yielding gain per patient 1017 months 95 confidence interval 747 1288 simplified costeffectiveness evaluation gain approximately 10 months per patient compared favorably device cost analysis provided original interpretation longterm evidence available mitraclip