Thomas Soroski, Kuda Hove, Lisa Steblecki, Jaime C Yu
Evaluating the domains of generalism and equity, diversity and inclusion in preclinical simulated cases for targeted curricular improvements
Medical education online
work proteinsurface interactions probed terms adsorption desorption model protein bovine serum albumin lowfouling surface singlemolecule localization microscopy singlemolecule experiments enable precise determination adsorption desorption rates strikingly experimental data show anomalous desorption kinetics evident surface dwell time exhibits powerlaw distribution ie heavytailed rather expected exponential distribution direct consequence heavytailed distribution average desorption rate depends upon time scale experiment protein surface concentration reach equilibrium analysis reveals observed anomalous desorption emerges due reversible formation small fraction soluble protein multimers small oligomers one desorbs surface different rate overall kinetics described series elementary reactions yielding simple scaling relations predict experimental observations work reveals mechanistic origin anomalous desorption kinetics employed interpret observations lowprotein fouling surfaces eventually foul longterm contact protein solutions work also provides new insights used define design principles nonfouling surfaces predict performance