Jonas A. de Souza|Bonnie J. Yap|Fay J. Hlubocky|Kristen Wroblewski|Mark J. Ratain|David Cella|Christopher K. Daugherty
The development of a financial toxicity patient-reported outcome in cancer: The COST measure
University of Chicago|University of Chicago|University of Chicago|University of Chicago|University of Chicago|Northwestern University|University of Chicago
considering patients experience essential optimal decisionmaking however despite increasing recognition impact costs oncology care patientreported outcome measure prom specifically describes financial distress experienced patientsthe content comprehensive score financial toxicity cost developed stepwise approach step 1 literature review semistructured qualitative interviews patients content generation step 2 patients assessment items importance quality life step 3 pilot testing assessing interitem iic itemtotal itc correlations identify redundancy spearman rho 07 statistically unrelated content p 05 step 4 exploratory factor analysis sociodemographic data collectedin total 155 patients advanced cancer receiving treatment 20 patients step 1 35 patients step 2 100 patients steps 3 4 participated prom development step 1 literature reviewed 20 patients generated 147 items reduced 58 items redundancy step 2 35 patients rated 58 items importance 30 items retained step 3 46 patients assessed 30 items 14 items excluded high iic 3 excluded nonsignificant itc step 4 2 items discarded poor loadings factor analysis 100 patients resulting 11item promthe content financial toxicity prom developed 155 patients provisional cost measure demonstrated face content validity well internal consistency validated larger samples