Cadmon K.P. Lim|Amabel May-Bo Wong|Connie Suk?Han Ho|Mary Miu Yee Waye
A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children
Chinese University of Hong Kong|Chinese University of Hong Kong|University of Hong Kong|Chinese University of Hong Kong
previous studies shown kiaa0319 candidate gene dyslexia western populations view different languages used caucasian chinese populations aim present study investigate whether also association kiaa0319 chinese children dyslexia andor languagerelated cognitive skills total twenty six single nucleotide polymorphisms snps genotyped three hundred ninety three individuals 131 chinese families four snps reported literature twenty two tag snps kiaa0319 analysis allelic haplotypic associations performed unphased program multiple testing corrected using permutation results indicate kiaa0319 associated chinese children dyslexia haplotype consisting rs2760157 rs807507 snps significantly associated onset detection test measure phonological awareness p nominal 685 10 5 p corrected 00029 conclusion findings suggest kiaa0319 associated readingrelated cognitive skill