Alexander Lepe, Liza A Hoveling, Michaël Boissonneault, Joop A A de Beer, Sijmen A Reijneveld, Marlou L A de Kroon, Aart C Liefbroer
Educational inequalities in major depressive disorder prevalence, timing and duration among adults over the life course: a microsimulation analysis based on the Lifelines Cohort Study
European journal of public health
studies confirmed anxiety especially worry rumination associated increased risk cognitive decline including alzheimers disease related dementias adrd hippocampal atrophy hallmark adrd investigated association hippocampus subfield volumes latelife global anxiety worry rumination emotion regulation strategies recruited 110 participants varying worry severity underwent magnetic resonance imaging clinical interviews conducted crosssectional regression analysis subfield anxiety worry rumination reappraisal suppression adjusting age sex race education cumulative illness burden stress neuroticism intracranial volume imputed missing data corrected multiple comparisons across regions greater worry associated smaller subiculum volume whereas greater use reappraisal associated larger subiculum ca1 volume greater worry may detrimental hippocampus subfields involved early adrd pathology use reappraisal appears protective hippocampal structure worry reappraisal may modifiable targets adrd prevention