Sirenda Vong|Virak Khieu|Olivier Glass|Sowath Ly|Veasna Duong|Rekol Huy|Ngan Chantha|Ole Wichmann|G. William Letson|Harold S. Margolis|Philippe Buchy
Dengue Incidence in Urban and Rural Cambodia: Results from Population-Based Active Fever Surveillance, 2006–2008
Institut Pasteur du Cambodge|Institut Pasteur du Cambodge|Institut Pasteur du Cambodge|Institut Pasteur du Cambodge|Institut Pasteur du Cambodge|Ministry of Health|Ministry of Health|International Vaccine Institute|International Vaccine Institute|International Vaccine Institute|Institut Pasteur du Cambodge
background dengue vaccines latestage development evaluation robust estimates dengue disease burden needed facilitate development introduction cambodia national dengue casedefinition allows reporting children less 16 years age little known dengue burden rural areas among older persons estimate true burden dengue largest province cambodia kampong cham conducted communitybased active dengue fever surveillance among 0to19year age group rural villages urban areas 20062008 methods findings active surveillance febrile illness conducted 32 villages 10 urban areas mothers trained use digital thermometers combined weekly home visits identify persons fever investigation team visited families febrile persons obtain informed consent participation followup study included collection personal data blood specimens denguerelated febrile illness defined using molecular serological testing paired acute convalescent blood samples three years surveillance 6121 fever episodes identified 736 laboratoryconfirmed dengue virus denv infections incidences 1345781000 personseasons average incidence highest among children less 7 years age 4111000 personseasons lowest among 16to19year age group 1131000 personseasons distribution dengue highly focal incidence rates villages urban areas ranging 1521151000 personseasons median 365 denv3 outbreak 2007 rural areas affected urban areas incidence 71 vs 171000 personseasons p0001 conclusion largescale active surveillance study dengue fever cambodia found higher disease incidence reported national surveillance system particularly preschool children disease incidence high rural urban areas also confirmed previously observed focal nature dengue virus transmission