Benjamin Dauphin, Christian Rellstab, Rafael O Wüest, Dirk N Karger, Rolf Holderegger, Felix Gugerli, Stéphanie Manel
Re-thinking the environment in landscape genomics
Trends in ecology & evolution
globally 2012 12 million estimated cases reported 135000 deaths annually ethiopia specifically study area limited information found oropharyngeal carriage antimicrobial resistance pattern associated risk factors n meningitidis among school children aim study assess oropharyngeal carriage rate n meningitidis antibiotic susceptibility pattern associated risk factors among primary school children gondar town northwest ethiopia cross sectional study conducted january april 2019 gondar town multi stage simple random sampling technique used total 524 oropharyngeal swabs collected using sterile plastic cotton swabs modified thayer martin media used primary isolation antimicrobial susceptibility pattern done based kirbybauer method mullerhinton agar supplemented 5 sheep blood multidrug resistance defined resistance isolate two antimicrobial classes tested logistic regression model used see association dependent variables carriage rate neisseria meningitidis serogroups neisseria meningitidis antimicrobial susceptibility patterns independent variables sociodemographic data risk factors variables p value 02 bivariable analysis taken multivariable analysis check significant association meningococcal carriage risk factors finally pvalue 005 considered statistically significant data summarized using numbers percentages tables total 53101 ci 76128 n meningitidis isolates identified serogroup 13 245 prevalent followed yw135 11207 whereas serogroup b 476 least identified serotype meningococcal isolates resistant ciprofloxacin 453 trimethoprimsulfamethoxazole 736 overall meningococcal isolates showed 32604 multidrug resistance meningococcal carriage rate significantly associated family size tonsillectomy passive smoking number students per class sharing utensils history visiting healthcare institutions indoor kitchen study highlights need reinforcement casebased laboratory confirmed surveillance n meningitidis carriage ethiopian elementary school students enable mapping distribution serotypes causative organisms across country determine current potential necessity vaccination