Sodiomon B. Sirima|Amadou T. Konaté|Alfred B. Tiono|Nathalie Convelbo|Simon Cousens|Franco Pagnoni
Early treatment of childhood fevers with pre?packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso
Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|Centre National de Recherche et de Formation sur le Paludisme|London School of Hygiene & Tropical Medicine|Ministero degli Affari Esteri|Centre National de Recherche et de Formation sur le Paludisme
summary rural malariaendemic burkina faso evaluated impact use prepackaged antimalarial drugs ppam mothers home progression disease children uncomplicated fever severe malaria village one province core group opinion leaders mainly older mothers trained management uncomplicated malaria including administration ppam full courses antimalarial chloroquine antipyretic aspirin drugs packaged agespecific bags made widely available community health workers supplied existing drug distribution system drugs sold costrecovery scheme local schoolteachers conducted surveys random sample 32 villages end high transmission seasons 1998 1999 disease history treatment received investigated children age 6 years suffered fever episode previous 4 weeks uncomplicated malaria defined every episode fever severe malaria every episode fever followed convulsions loss consciousness study period 5695 confidence interval ci 5062 3202 fever episodes children 6 years age treated promptly mothers prepackaged drugs made available study total 59 children receiving ppam reported received drugs prescribed 3day period 52 received correct agespecific dose ppam use similar among literate 61 nonliterate mothers 55 p 008 overall reported risk developing severe malaria 8 risk lower children treated ppam 5 children treated ppam 11 risk ratio 047 95 ci 037 060 p lt 00001 estimate impact ppam largely unchanged account taken potential confounding age sex maternal literacy status year village findings support view appropriate training adequately packaged drugs made available mothers recognize treat promptly correctly malarial episodes children reduce incidence severe disease