Ken Junyang Goh|Anthony Yii|Thérèse S. Lapperre|Adrian Chan|Fook Tim Chew|Sanjay H. Chotirmall|Mariko Siyue Koh
Sensitization to &lt;em&gt;Aspergillus &lt;/em&gt;species is associated with frequent exacerbations in severe asthma
Singapore General Hospital|Singapore General Hospital|National University of Singapore|Singapore General Hospital|National University of Singapore|Singapore General Hospital|National University of Singapore|Sea Level Research (United Kingdom)|Nanyang Technological University|Singapore General Hospital
severe asthma largely heterogeneous disease varying phenotypic profiles relationship specific allergen sensitization asthma severity particularly asia remains unclear aim study prevalence specific allergen sensitization patterns investigate association outcomes severe asthma cohort asian settingwe conducted crosssectional study patients receiving step 4 5 global initiative asthma treatment univariate multivariate analyses performed assess association sensitization specific identifiable allergen skin prick test spt uncontrolled asthma defined study use 2 steroid bursts hospitalization past year history nearfatal asthma evidence airflow obstruction spirometrytwo hundred six severe asthma patients mean age 4517 years 99 481 male evaluated 782 positive spt one allergens common allergen patients sensitized house dust mites blomia tropicalis dermatophagoides pteronyssinus dermatophagoides farinae also 117 sensitized aspergillus species multivariate analysis aspergillus sensitization associated uncontrolled asthma odds ratio 607 95 confidence interval 1802051 particular aspergillus sensitization independently associated use 2 steroid bursts past year odds ratio 305 95 confidence interval 104895 similar associations uncontrolled asthma sensitization allergens foundhigh allergen specifically aspergillus sensitization observed asian population severe asthma spt aspergillus sensitization specifically associated frequent exacerbations greater corticosteroid requirement improved understanding severe asthma aspergillus sensitization phenotype warranted likely subgroup severe asthma fungal sensitization