Fan Zhang, Xiaowei Huang, Hui Wang, Yan Bai, Liuyan Huang, Yi Li, Yifei Zhong
Prevalence of obstructive sleep apnea in whole spectrum chronic kidney disease patients: A systematic review and meta-analysis
Sleep medicine
current treatments chronic hepatitis b management include orally administered nucleostide analogues tenofovir tdf acyclic adenine nucleotide analogue used hbv human immune deficiency virus hiv course hbv infection mainly dependent viral factors hbv genotypes immunological features host genetic variables data available context hbv particular polymorphisms genes encoding proteins involved drug metabolism elimination consequently aim study evaluate potential impact genetic variants tdf plasma urine concentrations patients hbv considering role hbv genotypes retrospective cohort study infectious disease unit amedeo di savoia hospital torino italy performed pharmacokinetic analyses performed liquidi chromatography whereas pharmacogenetic analyses realtime pcr sixty eight patients analyzed abcc4 4976 ct genetic variant showed impact urine tdf drug concentrations p 0014 addition slc22a6 453 aa retained final regression multivariate model considering factors predicting plasma concentrations abcc4 4976 tccc predictor urine concentrations univariate model conclusion first study showing potential impact genetic variants tdf plasma urine concentrations hbv context studies different larger cohorts patients required