Ga Hee Lee, Jeong Hee Kim, Sungroul Kim, Sangwoon Lee, Dae Hyun Lim
Effects of Indoor Air Purifiers on Children with Asthma
Yonsei medical journal
recently racemic ketamine sketaminerketamine 5050 used study nmda receptor hypofunction relation pathophysiological models schizophrenia ketamine given normal humans subanesthetic doses produces model psychosis including positive negative symptoms schizophrenia recently shown subanesthetic doses pure rketamine enantiomeres interact differently nmda sigma receptor sites human brain found sketamine binds 34 time higher affinity pcp binding site nmda receptor rketamine concentrations rketamine interacts also weakly sigma receptor sites sketamine binds negligibly investigate role nmdareceptor mediated neurotransmission schizophrenic psychosis effects pure rketamine enantiomeres brain energy metabolism normal humans using positron emission tomography 18ffluorodeoxyglucose fdg reported psychotomimetic doses sketamine increased cerebral metabolic rates glucose cmrglu markedly frontal cortex including anterior cingulate parietal left sensorimotor cortex thalamus metabolic changes frontal left temporal cortex correlated egodisintegration hallucinatory phenomena equimolar doses rketamine tended decrease cmrglu across brain regions significantly suppressed cmrglu temporomedial cortex left insula rketamine produce psychotic symptoms state relaxation sketamineinduced metabolic hyperfrontality appears parallel similar metabolic findings acute psychotic schizophrenic patients encourages investigations glutamatergic disturbances schizophrenia