Ryan G. Vandrey|Michael T. Smith|Una D. McCann|Alan J. Budney|Erin M. Curran
Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal
Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|Johns Hopkins Medicine|Johns Hopkins University|University of Arkansas for Medical Sciences|Johns Hopkins Medicine|Johns Hopkins University
sleep difficulty common symptom cannabis withdrawal little research objectively measured sleep explored effects hypnotic medication sleep cannabis withdrawaltwenty daily cannabis users completed withinsubject crossover study participants alternated periods ad libitum cannabis use shortterm cannabis abstinence 3 days placebo administered bedtime one abstinence period withdrawal test extendedrelease zolpidem nonbenzodiazepine gabaa receptor agonist administered polysomnographic psg sleep architecture measures subjective ratings cognitive performance effects assessed dayduring placeboabstinence period participants decreased sleep efficiency total sleep time percent time spent stage 1 stage 2 sleep rem latency subjective sleep quality well increased sleep latency time spent rem sleep compared using cannabis zolpidem attenuated effects abstinence sleep architecture normalized sleep efficiency scores effect sleep latency zolpidem associated significant side effects nextday cognitive performance impairmentsthese data extend prior research indicates abrupt abstinence cannabis lead clinically significant sleep disruption daily users findings also indicate sleep disruption associated cannabis withdrawal attenuated zolpidem suggesting hypnotic medications might useful adjunct pharmacotherapies treatment cannabis use disorders