Kok Suen Cheng, Rongbin Pan, Huaping Pan, Binglin Li, Stephene Shadrack Meena, Huan Xing, Ying Jing Ng, Kaili Qin, Xuan Liao, Benson Kiprono Kosgei, Zhipeng Wang, Ray P S Han
ALICE: a hybrid AI paradigm with enhanced connectivity and cybersecurity for a serendipitous encounter with circulating hybrid cells
Theranostics
many population genomic studies conducted past search traces recent events positive selection traces however obscured temporal variation population size demographic factors reduce confounding impact demography coalescent tree topology used additional source information detecting recent positive selection population species based branching pattern root partition hypothetical coalescent tree inferred sequence sample two subtrees reasoning positive selection could impose strong impact branch length one two subtrees demography effect average subtrees thus positive selection detectable comparing statistics calculated two subtrees simulations demonstrate proposed test based principles high power detect recent positive selection even dna polymorphism data one locus available robust confounding effect demography one feature components summary statistics formula see text computed analytically moreover misinference derived ancestral alleles seen limited effect test therefore avoids notorious problem searching traces recent positive selection