Wei Hu, Xiang Song, Haibo Yu, Sophia Fan, Andrew Shi, Jingyu Sun, Hongjun Wang, Laura Zhao, Yong Zhao
Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SCs) through the Galectin-9-Dependent Mechanism
International journal of molecular sciences
leptomeningeal carcinomatosis lmc metastatic spread cancer leptomeninges rare complication dismal prognosis due limited data available lmc india conducted countrywise audit lmc across 15 centres india current study conducted 2020 retrospective multicentric audit adult patients aged 18 years diagnosis lmc received treatment 20102020 baseline characteristics details related previous treatments cancer sites lmc diagnosis treatment pattern overall survival os collected descriptive statistics performed kaplan meier analysis performed estimation os among patients diagnosed lmc n 84 diagnosis confirmed 52 patients 619 probable 32 381 patients three common cause malignancy nonsmall cell lung cancer nsclc breast cancer gastrointestinal cancer 45 536 22 261 9 107 patients respectively intrathecal therapy offered 33 patients 393 common intrathecal agent methotrexate 23 patients 274 median os 90 days 95 ci 48128 among tested variables intrathecal therapy administration hazard ratio hr 036 95 ci 019068 primary lung hr 043 95 ci 023083 favourable impact os prognosis leptomeningeal carcinomatosis poor significant burden morbidity mortality india data aims highlight current outcomes facilitate research lmc none