Xianling Zhang, Bo Li, JiaXin Mao, Richolsik, Ruipeng Zhang, Shabnam Faiz, MuXin Zhao
A Bibliometric and Visualisation Analysis on the Research of Female Genital Plastic Surgery Based on the Web of Science Core Collection Database
Aesthetic plastic surgery
functions cerebellar cortex motor learning emotion cognition depend appropriate molecular composition diverse synapse types glutamate receptor distributions partially mapped using immunogold electron microscopy however information lacking distribution many components shank2 postsynaptic scaffolding protein whose cerebellar dysfunction associated autism spectrum disorders used adapted magnified analysis proteome expansion microscopy approach map multiple glutamate receptors scaffolding signaling proteins single synapse resolution cerebellar cortex multiple distinct synapseselective distribution patterns observed example ampa receptors concentrated synapses molecular layer interneurons climbing fiber synapses shank1 concentrated parallel fiber synapses purkinje cells shank2 climbing fiber parallel fiber synapses purkinje cells little molecular layer interneurons results consistent gene expression data also reveal inputselective targeting within purkinje cells specialized glomerular structures granule cell layer ampa receptors well synaptic components preferentially targeted synapses however nmda receptors synaptic gtpase activating protein syngap preferentially targeted extrasynaptic sites thus glomeruli may considered integrative signaling units mossy fibers differentially activate synaptic ampa extrasynaptic nmda receptor complexes furthermore observed nmda receptors syngap adherens junctions suggesting role structural plasticity glomeruli altogether data contribute mapping cerebellar synaptome