Lawrence Mbuagbaw|Mia L. van der Kop|Richard Lester|Harsha Thirumurthy|Cristian Pop?Eleches|Chenglin Ye|Marek ?mieja|Lisa Dolovich|Edward J. Mills|Lehana Thabane
Mobile phone text messages for improving adherence to antiretroviral therapy (ART): an individual patient data meta-analysis of randomised trials
Central Hospital of Yaoundé|McMaster University|St. Joseph’s Healthcare Hamilton|Karolinska Institutet|University of British Columbia|University of British Columbia|BC Centre for Disease Control|University of Manitoba|University of Nairobi|University of North Carolina at Chapel Hill|Columbia University|McMaster University|St. Joseph’s Healthcare Hamilton|St. Joseph’s Healthcare Hamilton|McMaster University|St. Joseph’s Healthcare Hamilton|McMaster University|University of Ottawa|Population Health Research Institute|Hamilton Health Sciences|McMaster University|St. Joseph’s Healthcare Hamilton
objectives analyse effects text messaging versus usual care improving adherence antiretroviral therapy art people living hiv using individual patient data metaanalysis adjusted sensitivity subgroup analyses conducted3 randomised controlled trials conducted 2010 2012 rural urban centres cameroon kenya two studies useda total 1166 participants included analysis cameroon200 kenya428 538the primary outcome adherence art 95 secondary outcomes mortality losses followup transfers withdrawalstext messaging improved adherence art 138 95 cis 108 178 p0012 even adjustment baseline covariates 146 95 ci 113 188 p0004 primary education compared formal education associated greater intervention effect adherence 165 95 ci 110 248 p0016 also showed significant subgroup effect p0039 sensitivity analysis findings robust modified threshold adherence multiple imputation missing data aggregate level data pooling fixedeffects metaanalyses using generalised estimation equations significant subgroup effect long weekly p0037 short weekly text messages p0014 interactive messaging p0010 text messaging significantly affect secondary outcomestext messaging significant effect adherence art effect influenced level education gender timing weekly vs daily interactivity recommend use interactive weekly text messaging improve adherence art effective least primary level education