S D Radic, B A Milenkovic, B S Gvozdenovic, Z M Zivkovic, I M Pesic, D D Babic
The correlation between parental education and their knowledge of asthma
Allergologia et immunopathologia
transplantation hla andor kir mismatched allogeneic hematopoietic stem cells lead nk cells different states activationinhibition educationresetting change antitumor immunosurveillance study used molecular relapse monitoring investigate correlation either missing ligand recognition variation cognate ikirhla pairs clinical outcomes patients hematological malignancies requiring allogeneic hematopoietic stem cell transplantation allohsct patients n 418 acute myeloid leukemia aml chronic myeloid leukemia cml acute lymphoblastic leukemia myelodysplastic syndrome mds lymphoma receiving tcell repleted graft hlamatched partly mismatched unrelated donors 2012 2020 center included study missingligand recognition assessed presence absence recipients hla ligand particular inhibitory kir ikir exhibited donor inhibitory kirhla pair number variation defined loss gain new cognate pair hlakir within new hla environment recipient compared donors one considering results research drew following conclusions loss ikirhla cognate pair c1 c2 andor bw4 groups led significant deterioration diseasefree survival dfs molecular relapse overall survival os nonrelapse mortality nrm patients undergoing allohsct standard phase disease phenomenon observed patients underwent transplantation advanced hematological cancer ii missing ligand recognition impact proportion hla mismatches considered however adjustments hla mismatch level compared groups highlighted adverse effect missing ligand constellation iii adverse effect adjusted missing ligand suggests predominance lost nk cell education lost nk cell inhibition posttransplant recipients new hla environment results suggested donors loss ikirhla cognate pair transplantation avoided donors provided additional ikirhla cognate pair preferred allohsct donor selection process