Joanne Graham|Marjorie J Haskell|Pooja Pandey|Ram K. Shrestha|Kenneth H. Brown|Lindsay H. Allen
Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A–fortified rice in iron-deficient, pregnant, nightblind Nepali women
Western Human Nutrition Research Center|University of California, Davis|Western Human Nutrition Research Center|University of California, Davis|Western Human Nutrition Research Center|University of California, Davis|Western Human Nutrition Research Center|University of California, Davis|Western Human Nutrition Research Center|University of California, Davis|Western Human Nutrition Research Center|University of California, Davis
nightblindness affects 1652 pregnant women areas nepal cases persists vitamin treatment iron riboflavin affect vitamin utilization photoreceptor function respectively pilot data study population showed high prevalence iron riboflavin deficienciesthe objective assess effect supplemental iron riboflavin pupillary threshold pt plasma retinol nightblind pregnant nepali women given vitamin afortified ricenightblind pregnant women randomly assigned receive 6 dwk supervision 6 wk vitamin afortified rice curry dish providing 850 microg retinal activity equivalentsd either 30mg fe 6mg riboflavin fer va capsule placebo control va capsule hemoglobin erythrocyte riboflavin plasma ferritin retinol measured intervention dark adaptation assessed pt scorewomen iron deficient baseline n38 significantly greater improvement pt score iron riboflavin supplementation without p005 iron riboflavin supplements significantly reduced prevalences riboflavin deficiency 60 6 p00001 iron deficiency anemia 35 15 p0007 abnormal pt 87 30 p005 baseline mean increases erythrocyte riboflavin p00001 plasma ferritin p001 greater fer va group va groupiron deficiency may limit efficacy vitamin normalize dark adaptation pregnant nepali women studies needed assess effect simultaneous delivery iron vitamin treatment nightblindness