Hadi Kharrazi|Chenguang Wang|Daniel O. Scharfstein
Prospective EHR-Based Clinical Trials: The Challenge of Missing Data
Johns Hopkins University|Sidney Kimmel Comprehensive Cancer Center|Johns Hopkins University|Johns Hopkins University
discussion focuses challenges using prospectively collected electronic health record ehr data outcomes clinical trials particular emphasis issue missing data discussion motivated article issue translating hemoglobin a1c easily understood feedback randomized controlled trial gopalan et al1 spirit open science authors generously shared study protocol statistical analysis plan analysis data set using data set conducted analyses help emphasize important statistical issues editorial considered criticism paper rather study used reference expand challenges missing data ehrs provide suggestions future studies