Mukesh Dherani|Gudlavalleti Venkata Satyanarayana Murthy|Sanjeev Kumar Gupta|Ian S. Young|G Maraini|Monica Camparini|Gill M Price|Nitin Ashok John|Usha Chakravarthy|Astrid E. Fletcher
Blood Levels of Vitamin C, Carotenoids and Retinol Are Inversely Associated with Cataract in a North Indian Population
London School of Hygiene & Tropical Medicine|All India Institute of Medical Sciences|All India Institute of Medical Sciences|University of Parma|University of Parma|London School of Hygiene & Tropical Medicine|All India Institute of Medical Sciences|Queen's University Belfast|London School of Hygiene & Tropical Medicine
purpose examine association blood antioxidants cataract methods crosssectional study people aged 50 years identified household enumeration 11 randomly sampled villages north india participants interviewed putative risk factors tobacco alcohol biomass fuel use sunlight exposure socioeconomic status underwent lens photography blood sampling lens photographs nuclear cortical posterior subcapsular graded according lens opacities classification system locs ii cataract defined locs ii grade 2 opacity ungradable dense opacification history cataract surgery people without cataract defined locs ii 2 three types opacity absence previous surgery results 1443 people aged 50 years 94 interviewed 87 attended eye examination 78 gave blood sample 1112 77 included analyses compared levels western populations antioxidants low especially vitamin c vitamin c inversely associated cataract odds ratios highest 15 moll compared lowest 63 moll tertile 064 95 confidence interval ci 048085 p 001 tertiles zeaxanthin p 003 carotene p 005 retinol p 002 associated decreased odds cataract analysis continuous data significant inverse associations found vitamin c zeaxanthin lutein lycopene carotene cryptoxanthin tocopherol conclusions inverse associations found cataract blood antioxidants antioxidantdepleted study sample