Matthew M. Kurtz|James C. Seltzer|Dana Shagan|Warren Thime|Bruce E. Wexler
Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient?
Yale University|Institute for Community Living|Institute for Community Living|Institute for Community Living|Institute for Community Living|Yale University
emerging body research shown computerassisted cognitive remediation consisting training attention memory language andor problemsolving produces improvement neurocognitive function generalizes untrained neurocognitive tests may also impact symptoms work functioning patients schizophrenia active ingredient interventions however remains unknown control groups studies typically included elements complex behavioral treatments study compared effects extended 12month standardized computerassisted cognitive remediation intervention computerskills training control condition consisted many elements experimental intervention including hours spent computer interaction clinician nonspecific cognitive stimulation fortytwo patients schizophrenia randomly assigned one two conditions assessed comprehensive neuropsychological test battery treatment results revealed cognitiveremediation training produced significant improvement working memory relative computersskills training control condition overall improvement groups measures working memory reasoningexecutivefunction verbal spatial episodic memory processing speed taken together findings suggest specific practice neurocognitive exercises targeted attention memory language produce improvements neurocognitive function solely attributable nonspecific stimulation associated working computer interacting clinician cognitive challenge nonspecific stimulation salutary effect neurocognition well