Lisa S Wallace, Ololade Okito, Kelsi Mellin, Lamia Soghier
Associations between Parental Engagement in the Neonatal Intensive Care Unit and Neighborhood-Level Socioeconomic Status
American journal of perinatology
obligate intracellular bacterial pathogen chlamydia trachomatis leading cause sexually transmitted infections infectious blindness chlamydia undergo biphasic developmental cycle alternating infectious elementary body eb replicative reticulate body rb molecular mechanisms governing rb growth rbeb differentiation unclear hypothesize bacterium senses host cell bacterial energy levels metabolites ensure development growth coincide nutrient availability predict partner switching mechanism psm plays key role sensing response process acting molecular throttle sensitive metabolite levels using purified wild type mutant psm proteins discovered metal type impacts enzyme activity substrate specificity rsbu rsbw prefers atp gtp phosphate donor immunoblotting analysis rsbv1v2 demonstrated presence proteins beyond 20 hours post infection observed rsbv1null strain developmental delay exhibits differential growth attenuation response glucose levels collectively data support psm regulates growth response metabolites defines biochemical features governing psmcomponent interactions could help development novel psmtargeted therapeutics