Xinchi Wang, Tingting Yang, Longxiang Fang, Yong Yang, Haitao Zhang, Jianghua Yang, Changbo Wang, Limin Fan, Xuelei Zang, Shunlong Meng, Chao Song
Citizen science in action: Time-resolved immunofluorescence-based field detection of antibiotics with portable analytical kit
The Science of the total environment
longterm effect interventions assist patients establishing endoflife care preferences among patients cancer remain relatively unknown evaluate association longterm intervention lay health workerled advance care planning intervention among patients advanced stages cancer overall survival endoflife health care use costs followup study epac randomized clinical trial conducted august 2013 february 2015 used data 94 years first patient enrolled data cutoff date february 1 2023 overall 213 participants stage 3 4 recurrent cancer us veterans affairs palo alto health care system included 6month lay health workerled education support intervention assist patients establishing endoflife preferences vs usual care outcomes interest overall survival risk death restricted mean survival time palliative care hospice acute care use final 30 days death participants died among 213 participants randomized included intentiontotreat analysis mean sd age 693 91 years 211 991 male 2 090 female demographic clinical characteristic imbalances enrollment february 1 2023 188 died intervention group 25 reduction risk death hazard ratio 075 95 ci 056098 palliative care 44 500 vs 35 350 hospice use 64 727 vs 53 530 lower emergency department use 20 227 vs 47 470 hospitalizations 17 193 vs 46 460 median iqr total health care costs median iqr 1637 3839026 vs 18 520 479050 729 control group participants effects lay health workerled intervention remain durable nearly complete followup supporting integration routine cancer care clinicaltrialsgov identifier nct02966509