Mary L Padden-Denmead, Mark Adelung, Jacqueline Arnone, Lia Ludan, Larider Ruffin, Rose M Scaffidi
Nursing Students' Perceptions of Racism in Nursing and Health Care
The Journal of nursing education
obeticholic acid oca licensed secondline therapy primary biliary cholangitis pbc novel therapeutics advanced development clinical tools needed tailor treatment algorithm aimed derive externally validate oca response score ors predicting response probability individuals pbc oca used data italian recapitulate n 441 iberpbc n 244 oca realworld prospective cohorts derivevalidate score including widely available variables obtained either pretreatment ors also 6 months treatment ors multivariable coxs regressions backward selection applied obtain parsimonious predictive models predicted outcomes biochemical response according poise alpuln167 reduction least 15 normal bilirubin alpuln167 normal range criteria nr normal alp alt bilirubin 24 months depending response criteria ors included age pruritus cirrhosis alpuln altuln ggtuln bilirubin ors also included alpuln bilirubin 6 months oca therapy internally validated cstatistics ors 075 078 072 poise alpuln167 nr response raised 083 088 081 ors respectively respective performances validation 070 072 071 ors 080 084 078 ors results consistent across groups mildsevere disease developed externally validated scoring system capable predict oca response according different criteria tool enhance stratified secondline therapy model streamline standard care trial delivery pbc