Donna K. Arnett|Alison E. Baird|Ruth Ann Barkley|Craig T. Basson|Eric Boerwinkle|Santhi K. Ganesh|David M. Herrington|Yuling Hong|Cashell E. Jaquish|Deborah A. McDermott|Christopher J. O’Donnell
Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease
atherosclerotic cardiovascular disease cvd major health problem united states around world evidence accumulated decades convincingly demonstrates family history parent sibling associated atherosclerotic cvd manifested coronary heart disease stroke andor peripheral arterial disease although several mendelian disorders contribute cvd common forms cvd believed multifactorial result many genes relatively small effect working alone combination modifier genes andor environmental factors identification characterization genes modifiers would enhance prediction cvd risk improve prevention treatment quality care scientific statement describes approaches researchers using advance understanding genetic basis cvd details current state knowledge regarding genetics myocardial infarction atherosclerotic cvd hypercholesterolemia hypertension current areas interest investigationincluding geneenvironment interaction pharmacogenetics genetic counselingare also discussed statement concludes list specific recommendations intended help incorporate usable knowledge current clinical public health practice foster guide future research prepare researchers practitioners changes likely occur molecular genetics moves laboratory clinic