Anna Jesus, Carolyn Bennett, Chelsea Masterson, Laurie Brenner, Rebecca Scharf
Self- and Caregiver-Reported Participation, Quality of Life, and Related Mood and Behavior Challenges in People Living With Dystrophinopathies
Pediatric neurology
inconclusive evidence association per polyfluoroalkyl substances pfas fetal growth conducted nationwide registerbased cohort study assess associations estimated maternal exposure sum pfas4 perfluorooctane sulfonic acid pfos perfluorooctanoic acid pfoa perfluorononanoic acid pfna perfluorohexane sulfonic acid pfhxs birthweight well risk small sga largeforgestationalage lga included births sweden 20122018 mothers residing four years prior partus localities served municipal drinking water pfas measured raw drinking water using onecompartment toxicokinetic model estimated cumulative maternal blood levels pfas4 pregnancy linking residential history municipal pfas water concentration yearspecific background serum pfas concentrations sweden individual birth outcomes covariates obtained via register linkage mean values 95 confidence intervals ci coefficients odds ratios estimated linear logistic regressions respectively quantile gcomputation regression conducted assess impact pfas4 mixture among 248804 singleton newborns included overall association observed pfas4 birthweight sga however association seen lga multivariableadjusted 108 95 ci 101116 comparing highest pfas4 quartile lowest associations remained mixture effect approach pfas except pfoa contributed positive weight observed association sum pfas4 especially pfos increased risk lga sga birthweight limitations linked exposure assessment still require caution interpretation