Panying Rong|Yana Yunusova|Jun Wang|Jordan R. Green
Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach
MGH Institute of Health Professions|University of Toronto|The University of Texas at Dallas|MGH Institute of Health Professions
develop predictive model speech loss persons amyotrophic lateral sclerosis als based measures respiratory phonatory articulatory resonatory functions selected using datamining approachphysiologic speech subsystem respiratory phonatory articulatory resonatory functions evaluated longitudinally 66 individuals als using multiple instrumentation approaches including acoustic aerodynamic nasometeric kinematic instrumental measures subsystem functions subjected principal component analysis linear mixed effects models derive set comprehensive predictors bulbar dysfunction subsystem predictors subjected kaplanmeier analysis estimate time speech lossfor majority participants speech subsystem decline detectible prior declines speech intelligibility speaking rate among subsystems articulatory phonatory predictors responsive early bulbar deterioration resonatory respiratory predictors responsive bulbar decline speaking ratethe articulatory phonatory predictors sensitive indicators early bulbar decline due als implications predicting disease onset progression clinical management als