Pauline M. Maki|Mardge H. Cohen|Kathleen M. Weber|Deborah M. Little|Deanne Fornelli|Leah H. Rubin|Pamela Perschler|Felicia Gould|Eileen Martin
Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women
John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)|John H. Stroger, Jr. Hospital of Cook County|University of Illinois at Chicago|Rush University|Cook County Health and Hospitals System|Core Laboratories (United States)
objective neurocognitive studies hiv typically target executive functions dependent frontostriatal circuitrythe integrity medial temporal systems received considerably less attention despite high hippocampal viral loadstudies also predominately involve hiv men though hiv women may increased risk cognitive dysfunction due high prevalence psychosocialmental health problems lower educational attainmentour aim conduct preliminary investigation episodic memory neural correlates hivinfected atrisk uninfected women methods participants included 54 hiv 12 hiv women mean age 43 years 86 african american recruited chicago site womens interagency hiv studyparticipants completed standardized tests verbal visual episodic memory working memory executive functiona subset 11 women also underwent functional mri delayed verbal episodic memory taskresults hiv serostatus predicted significantly lower immediate delayed verbal episodic memory working memory visual memorypreliminary neuroimaging findings revealed group differences bilateral hippocampal function hiv women showing decreased activation encoding increased activation delayed recognitionthese alterations correlated worse episodic verbal memory conclusionsverbal episodic memory deficits evident hiv women may associated hippocampal dysfunction encoding retrieval