Markus Wolff|Nikolaus Weiskopf|Emilio Serra|Hubert Preissl|N Birbaumer|Ingeborg Krägeloh?Mann
Benign Partial Epilepsy in Childhood: Selective Cognitive Deficits Are Related to the Location of Focal Spikes Determined by Combined EEG/MEG
Uniwersytecki Szpital Dzieci?cy|Children's Clinical University Hospital|Institute of Neurobiology|University of Tübingen|Uniwersytecki Szpital Dzieci?cy|Children's Clinical University Hospital|Institute of Neurobiology|Institute of Neurobiology|University of Trento|Uniwersytecki Szpital Dzieci?cy|Children's Clinical University Hospital
benign partial epilepsy bpe childhood characterized occurrence interictal stereotyped focal spikes variable localization eeg children bpe often exhibit neuropsychological deficits unclear whether correlation exists deficits localization spikes several eeg studies giving inconsistent results magnetoencephalography meg improves accuracy spike localization therefore using combined megeeg investigated topographic relation focal spikes neuropsychological findings children bpetwentyseven children diagnosed consecutively bpe enrolled study examined combined megeeg magnetic resonance imaging mri location spikes determined dipole source estimation standardized neuropsychological assessment conducted including kaufman abc battery language tests motor performance series children sufficient meg data included correlation analysis n 20focal spikes located perisylvian region 13 children occipital region seven frontal region one five children bilateral multiple foci children left perisylvian spikes differ others global iq performed significantly lower language tests p 001 children occipital spikes performed significantly lower simultaneous information processing p 001 especially visual transformation taskscombined megeeg investigation useful tool examine interictal focal spikes results show correlation location spikes selective cognitive deficits children bpe findings indicate focal interictal spikes may interfere complex cognitive functions