Emily R Littman, Shazia Beg
Live Patient Encounters: A Perspective From Second-Year Medical Students
Cureus
mathematical methods information theory appear provide useful language describe stimuli encoded activities signaling effectors exploring informationtheoretic perspective however remains conceptually experimentally computationally challenging specifically existing computational tools enable efficient analysis relatively simple systems usually one input output moreover robust readily applicable implementations missing propose novel algorithm slemistatistical learning based estimation mutual information analyze signaling systems highdimensional outputs large number input values approach efficient terms computational time well sample size needed accurate estimation analysis nfb singlecell signaling responses tnf reveals nfb signaling dynamics improves discrimination high concentrations tnf relatively modest impact discrimination low concentrations provided rpackage allows approach used computational biologists elementary knowledge information theory