David J. Moore|Sonia Jain|Michael P. Dubé|Eric S. Daar|Xiaoying Sun|Jason A. Young|Katya Corado|Eric Ellorin|Joel Milam|Deborah Owens Collins|Jill Blumenthal|Brookie M. Best|Peter L. Anderson|Richard Haubrich|Sheldon Morris
Randomized Controlled Trial of Daily Text Messages to Support Adherence to Preexposure Prophylaxis in Individuals at Risk for Human Immunodeficiency Virus: The TAPIR Study
University of California, San Diego|University of California, San Diego|University of Southern California|Harbor–UCLA Medical Center|The Lundquist Institute|California State University, Long Beach|University of California, San Diego|University of California, San Diego|Harbor–UCLA Medical Center|The Lundquist Institute|California State University, Long Beach|University of California, San Diego|University of Southern California|Department of Health and Human Services|University of California, San Diego|University of California, San Diego|University of Colorado Denver|Gilead Sciences (United States)|University of California, San Diego
adherence critical efficacy tenofovir disoproxil fumarateemtricitabine ftc preexposure prophylaxis prepbetween february 2013 february 2016 398 men sex men transgender women randomized 11 receive individualized texting adherence building itab standard care soc 48 weeks primary endpoint dried blood spot dbs tenofovir diphosphate tfvdp concentrations week 12 last ondrug visit 719 fmolpunch ie adequate adherence secondary outcomes included dbs tfvdp concentrations 1246 fmolpunch ie nearperfect adherence plasma ftc 350 ngml consistent dosing within past 24 hoursconcentrations 719 fmolpunch tfvdp found 886 participants week 12 825 week 48 primary endpoint study arms differ 720 itab 692 soc p 05 secondary composite endpoint 1246 fmolpunch itab arm superior soc 335 vs 248 p 06 reaching statistical significance adjusting age odds ratio 156 95 confidence interval 100242 p 05 week 48 itab superior soc nearperfect adherence 510 vs 374 p 02 week 12 itab superior soc dosing past 24 hours plasma ftc 475 vs 333 p 007 weeks 24 36 48 p 05automated text messaging lowburden tool improves durability nearperfect prep adherencenct01761643