Hongmiao Ji, Sikai Tang, Xing Liu
Chewing ability and its associated factors among community-dwelling older adults in Chengdu, China: A cross-sectional study
Japan journal of nursing science : JJNS
data regarding safety antivascular endothelial growth factor antivegf treatment limitedto compare adverse events aes induced aflibercept ranibizumab using spontaneous reporting system determine signalswe used data korea institute drug safety risk managementkorea adverse event reporting system database kidskd collected 2007 2016 differences patient demographics report type reporter causality seriousaes aflibercept ranibizumab compared metrics including proportional reporting ratio prr reporting odds ratio ror information component ic used compare signals aes drug labels united states america korea logistic regression analysis performed identify aes likely occur drug usea total 32 aflibercept 103 ranibizumab cases aes identified proportion aes reported voluntarily higher aflibercept 505 use ranibizumab 49 whereas aes reported postmarketing surveillance higher ranibizumab 466 use aflibercept 313 percentage aes patients 60 years old reports consumers ratio saes aes associated aflibercept 84 94 750 respectively higher ranibizumab 777 19 194 respectively number newly detected aes aflibercept ranibizumab treatment 3 8 respectively among conjunctivitis medicine ineffective included aflibercept ranibizumab labels respectively endophthalmitis 696 95 ci 2741773 likely reported patients aflibercept patients without aflibercept whereas medicine ineffective 1849 95 ci 23914329 retinal disorder 703 95 ci 1603096 likely reported patients ranibizumab patients without ranibizumabnew signals identified aflibercept ranibizumab research necessary evaluate causality aes detected signals study