Sarvin Sasannia, Mitra Amini, Mahsa Moosavi, Amir Askarinejad, Mana Moghadami, Hasti Ziaee, Fatemeh Vara
Critical appraisal skills training to undergraduate medical students: A Randomized Control Study
Journal of advances in medical education & professionalism
prescriptionbased rxrisk index previously developed measure multimorbidity aimed adapt evaluate validity rxrisk index prediction mortality among persons type 2 diabetes registrybased study adults type 2 diabetes norway identified within outcomes multimorbidity type 2 diabetes cohort linkage prescriptions norwegian prescription database mortality population registry defined calibration sample 42 290 adults diagnosed type 2 diabetes 19502013 temporal validation sample 7085 adults diagnosed 20142016 evaluate index validity time primary outcome measure allcause mortality methods calibration sample dispensed drug prescriptions 2013 used define 44 morbidity categories weights estimated using regression coefficients cox regression model 5 year mortality outcome morbidity categories age sex included covariates rxrisk index computed weighted sum morbidities validity index evaluated using cstatistic calibration plots calibration sample mean sd age start followup duration diabetes 638 124 101 70 years respectively overall cstatistic 082 varied 074 085 stratifying age groups sex level education country origin validation sample mean sd age duration diabetes 597 130 20 08 years respectively despite younger age shorter duration diabetes later time period cindex high total sample 084 separately men 083 women 084 rxrisk index showed good discrimination calibration predicting mortality thus presents valid tool assess multimorbidity among persons type 2 diabetes