Stephanie W Cawthon, Elizabeth Barker, Johny Daniel, North Cooc, Ana G Vielma
Longitudinal Models of Reading and Mathematics Achievement in Deaf and Hard of Hearing Students
Journal of deaf studies and deaf education
creactive proteinalbuminlymphocyte cally score novel indicator associated inflammation immunity nutrition utilized cancer prognostic stratification study aimed evaluate integrated prognostic significance pretreatment cally score epsteinbarr virus ebv dna levels nasopharyngeal carcinoma npc patients develop prognostic models total 1707 npc patients september 2015 december 2017 retrospectively enrolled cutoff point cally score determined maximum selected rank statistics integrates published cutoff point preebv dna develop comprehensive index subsequently patients randomly allocated 11 ratio training validation cohorts survival analysis conducted using kaplanmeier method log rank tests cox proportional hazards model applied identify independent prognostic factors constructing predictive nomograms predictive ability nomograms assessed concordance index cindex calibration curves decision curve analysis integrating cally scores ebvdna levels patients categorized three risk clusters kaplanmeier curves reveal significant differences overall survival os distant metastasisfree survival dmfs locoregional relapsefree survival lrrfs outcomes among different risk groups p values 005 multivariate analysis revealed callyebv dna index serves independent prognostic factor os dmfs lrrfs prognostic nomograms based callyebv dna index provided accurate predictions 1year 3year 5year os dmfs lrrfs additionally compared traditional tnm staging system nomograms exhibited enhanced discriminatory power calibration capability clinical applicability results agreement validation cohort callyebv dna index independent prognostic biomarker nomogram prediction models constructed based callyebv dna index demonstrates superior predictive performance compared traditional tnm staging