Genetic mutations are considered the most identifiable cause of GIST. Around 95% of these mutations are sporadic (isolated) with less than 5% occur as part of hereditary, familial, or idiopathic multi tumor syndromes. Common causes of GIST include mutation in proto-oncogenes such as c-Kit gene and PDGFRA gene. These proto-oncogenes control cell multiplication and mutations in them can lead to excessive and uncontrolled cell multiplication leading to tumor formation. In other cases where the patient do not exhibit the typical mutation in c-Kit and PDGFRA gene, mutations in succinate dehydrogenase (SDH) gene have been reported. Rare genes involved include mutation in BRAF kinase and protein kinase C.
What causes Gastrointestinal stromal tumor?
Genetic mutations are considered the most identifiable cause of {{ORGANIZATION}}. Around 95% of these mutations are sporadic (isolated) with less than 5% occur as part of hereditary, familial, or idiopathic multi tumor syndromes. Common causes of GIST include mutation in proto-oncogenes such as c-Kit gene and PDGFRA gene. These proto-oncogenes control cell multiplication and mutations in them can lead to excessive and uncontrolled cell multiplication leading to tumor formation. In other cases where the patient do not exhibit the typical mutation in c-Kit and {{ORGANIZATION}} gene, mutations in succinate dehydrogenase ({{ORGANIZATION}}) gene have been reported. Rare genes involved include mutation in BRAF kinase and protein kinase C.