The outcome for people affected with alkaptonuria is generally expected to be good. Some possible complications include people with this condition also can get arthritis in adulthood. The build-up of homogentisic acid in the cartilage causes arthritis in about 50% of older adults with alkaptonuria.
Homogentisic acid also can build up on the heart valves, especially the mitral valve. This can sometimes lead to the need for valve replacement. Coronary artery disease may develop earlier in people with alkaptonuria. Kidney stones and prostate stones may be more common in people with alkaptonuria.
What to expect if I have Alkaptonuria  (Outlook/Prognosis)?
The outcome for people affected with alkaptonuria is generally expected to be good. Some possible complications include people with this condition also can get arthritis in adulthood. The build-up of homogentisic acid in the cartilage causes arthritis in about 50% of older adults with alkaptonuria.
Homogentisic acid also can build up on the heart valves, especially the mitral valve. This can sometimes lead to the need for valve replacement. Coronary artery disease may develop earlier in people with alkaptonuria. Kidney stones and prostate stones may be more common in people with alkaptonuria.