[Re-osseointegration of peri-implantitis bone defects: an experimental study in dogs].
PURPOSE
To investigate the treatment methods of experimentally induced peri-implantitis bone defects, and evaluate bone regeneration and re-osseointegration around implants histologically.


METHODS
30 Brinemark standard implants were placed in 5 Beagle dogs' mandibles to establish peri-implantitis bone defect model, then bone defects were randomly treated with: (1) debridement alone; (2) debridement plus guided bone regeneration using non-absorbable membrane; (3) debridement plus non-absorbable membrane associated with bone graft; (4) debridement plus non-absorbable membrane associated with biological activity glass. Peri-implant bone augmentation was observed and detected by radiography, fluorescence light micrography, un-decalcified bones ground section and direct measurement on operation. SPSS 12.0 software package was used for ANOVA, Kruskal-Wallis test and Mann-Whiteney test.


RESULTS
There were significant differences between four groups in peri-implant bone augmentation, bone contact level and bone mineralization apposition rate, P < 0.05. The group using debridement plus non-absorbable membrane associated with bone graft resulted in a greater amount of regeneration than the other treatments.


CONCLUSION
Inflammation induced peri-implant bone defects can regenerate by appropriate treatment. Supported by Shanghai Municipal Science and Technology Enhancement Award (Grant No.024119072).