Oxidative induction of beta-turn conformations in cyclic peptidomimetics: conformational analyses as indicators of configuration.
Solid-phase syntheses of the cyclic peptidomimetics 1-4 were performed. Sulfide 1 and sulfoxide 3 did not tend to exist in beta-turn conformations in solution, but the sulfone 2 and the epimeric sulfoxide 4 did. The assignment of configuration of the sulfoxides is based on the conformational analyses.