The intensity of the color shows the magnitude of reductions or promotions (Figure 3). It is this second class that provides the most interest. To improve the activity, combinations of two individual nanobodies were joined by a flexible linker to create drug candidates that might be more effective by binding to two different sites simultaneously. Stanford UniversityA series of experiments were done to link the nanobodies in sets of two or three to determine which combinations were the most potent neutralizers. This can be partially overcome by combining nanobodies, but not entirely because mutations may arise in both domains, which reduce potency.
The four experimental drug candidates, identified by the transmission of a series of experiments, were also unable to neutralize the virus.
( z0 possible :ARG1 ( z1 neutralize :ARG0 ( z2 candidate :quant 4 :ARG1-of ( z3 experiment ) :ARG1-of ( z4 identify :ARG0 ( z5 transmit :ARG1 ( z6 series :quant-of ( z7 experiment ) ) ) ) :mod ( z8 drug ) ) :ARG1 ( z9 virus ) ) :mod ( z10 also ) :polarity - )
(z0 / possible-01
    :ARG1 (z1 / neutralize-01
              :ARG0 (z2 / candidate
                        :quant 4
                        :ARG1-of (z3 / experiment-01)
                        :ARG1-of (z4 / identify-01
                                     :ARG0 (z5 / transmit-01
                                               :ARG1 (z6 / series
                                                         :quant-of (z7 / experiment-01))))
                        :mod (z8 / drug))
              :ARG1 (z9 / virus))
    :mod (z10 / also)
    :polarity -)
The four experimental drug candidates , identified by the transmission of a series of experiments , were also unable to neutralize the virus .
z2 :mod z8
z2 :ARG1-of z3
z2 :quant 1
z2 :ARG1-of z4
z4 :ARG0 z5
z5 :ARG1 z6
z6 :quant-of z7
z0 :mod z10
z0 :polarity 0
z0 :ARG1 z1
z1 :ARG0 z2
z1 :ARG1 z9