[
    {
        "instruction": "Which condition is asociated with RS1375421660 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1375421660 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1375421660 SNP."
    },
    {
        "instruction": "In which chromosome is RS1375421660 SNP located?",
        "output": "It is located in the chromosome 14."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1375421660 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1375421660 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1375421660 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1375421660 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1375421660 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1375421660 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853292 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853292 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853292 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853292 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853292 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853292 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS137853292 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853292 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853292 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853292 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776781 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776781 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776781 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776781 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776781 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776781 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776781 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776781 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776781 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776781 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL28119?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL28119. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL28119."
    },
    {
        "instruction": "In which chromosome is DEL28119 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL28119?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of DEL28119, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL28119?",
        "output": "The variation length is None base pairs."
    },
    {
        "instruction": "What is the origin for DEL28119?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL28119?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1555285429 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555285429 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555285429 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555285429 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555285429 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS1555285429 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555285429 SNP?",
        "output": "The variation length is 55 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555285429 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555285429 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555285429 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587776784 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776784 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776784 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776784 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776784 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776784 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776784 SNP?",
        "output": "The variation length is 10 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776784 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776784 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776784 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776785 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776785 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776785 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776785 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776785 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776785 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776785 SNP?",
        "output": "The variation length is 9 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776785 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776785 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776785 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS387906520 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS387906520 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS387906520 SNP."
    },
    {
        "instruction": "In which chromosome is RS387906520 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS387906520 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS387906520 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS387906520 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS387906520 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS387906520 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853295 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853295 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853295 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853295 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853295 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853295 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS137853295 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853295 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853295 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853295 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587776790 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776790 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776790 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776790 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776790 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776790 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776790 SNP?",
        "output": "The variation length is 23 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776790 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776790 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776790 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776791 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776791 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776791 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776791 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776791 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776791 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776791 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776791 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776791 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776791 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778858 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778858 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778858 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778858 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778858 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778858 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778858 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778858 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778858 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778858 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1566233014 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566233014 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566233014 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566233014 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566233014 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS1566233014 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566233014 SNP?",
        "output": "The variation length is None base pairs."
    },
    {
        "instruction": "What is the origin for RS1566233014 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566233014 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with RS587778833 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778833 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778833 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778833 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778833 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778833 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778833 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778833 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778833 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778833 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778865 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778865 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778865 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778865 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778865 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778865 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778865 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778865 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778865 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778865 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778866 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778866 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778866 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778866 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778866 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778866 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778866 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778866 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778866 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778866 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778834 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778834 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778834 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778834 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778834 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778834 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778834 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778834 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778834 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778834 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778859 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778859 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778859 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778859 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778859 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778859 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778859 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778859 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778859 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778859 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778835 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778835 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778835 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778835 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778835 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778835 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778835 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778835 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778835 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778835 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778868 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778868 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778868 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778868 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778868 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778868 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778868 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778868 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778868 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778868 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778861 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778861 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778861 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778861 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778861 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778861 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778861 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778861 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778861 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778861 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778826 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778826 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778826 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778826 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778826 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778826 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778826 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778826 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778826 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778826 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with 132325?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs132325. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/132325."
    },
    {
        "instruction": "In which chromosome is 132325 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 132325?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of 132325, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 132325?",
        "output": "The variation length is None base pairs."
    },
    {
        "instruction": "What is the origin for 132325?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for 132325?",
        "output": "The variation is a Variation."
    },
    {
        "instruction": "Which condition is asociated with RS587778843 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778843 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778843 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778843 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778843 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778843 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778843 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778843 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778843 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778843 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778855 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778855 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778855 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778855 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778855 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778855 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778855 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778855 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778855 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778855 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778856 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778856 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778856 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778856 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778856 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778856 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778856 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778856 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778856 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778856 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778845 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778845 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778845 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778845 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778845 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778845 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778845 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778845 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778845 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778845 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778847 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778847 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778847 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778847 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778847 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778847 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778847 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778847 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778847 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778847 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778863 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778863 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778863 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778863 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778863 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778863 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778863 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778863 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778863 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778863 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587781256 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587781256 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587781256 SNP."
    },
    {
        "instruction": "In which chromosome is RS587781256 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587781256 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587781256 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587781256 SNP?",
        "output": "The variation length is 21 base pairs."
    },
    {
        "instruction": "What is the origin for RS587781256 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587781256 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587781256 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS587781257 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587781257 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587781257 SNP."
    },
    {
        "instruction": "In which chromosome is RS587781257 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587781257 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587781257 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587781257 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587781257 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587781257 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587781257 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL399102?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL399102. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL399102."
    },
    {
        "instruction": "In which chromosome is DEL399102 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL399102?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL399102, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL399102?",
        "output": "The variation length is 2601 base pairs."
    },
    {
        "instruction": "What is the origin for DEL399102?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL399102?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL399611?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL399611. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL399611."
    },
    {
        "instruction": "In which chromosome is DEL399611 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL399611?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL399611, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL399611?",
        "output": "The variation length is 1850 base pairs."
    },
    {
        "instruction": "What is the origin for DEL399611?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL399611?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL463437?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL463437. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL463437."
    },
    {
        "instruction": "In which chromosome is DEL463437 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL463437?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL463437, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL463437?",
        "output": "The variation length is 41756 base pairs."
    },
    {
        "instruction": "What is the origin for DEL463437?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL463437?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1555282775 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555282775 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555282775 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555282775 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555282775 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555282775 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555282775 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555282775 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555282775 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555282775 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1555294600 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294600 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294600 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294600 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294600 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294600 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555294600 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294600 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294600 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294600 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL527719?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL527719. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL527719."
    },
    {
        "instruction": "In which chromosome is DEL527719 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL527719?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL527719, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL527719?",
        "output": "The variation length is 176171 base pairs."
    },
    {
        "instruction": "What is the origin for DEL527719?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL527719?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1566234123 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566234123 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566234123 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566234123 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566234123 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566234123 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566234123 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566234123 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566234123 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566234123 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566199059 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566199059 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566199059 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566199059 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566199059 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566199059 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566199059 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566199059 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566199059 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566199059 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186087 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186087 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186087 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186087 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186087 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186087 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566186087 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186087 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186087 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186087 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566233076 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566233076 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566233076 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566233076 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566233076 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566233076 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566233076 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566233076 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566233076 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566233076 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DEL568222?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL568222. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL568222."
    },
    {
        "instruction": "In which chromosome is DEL568222 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL568222?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL568222, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL568222?",
        "output": "The variation length is 176179 base pairs."
    },
    {
        "instruction": "What is the origin for DEL568222?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL568222?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL568225?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL568225. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL568225."
    },
    {
        "instruction": "In which chromosome is DEL568225 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL568225?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL568225, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL568225?",
        "output": "The variation length is 132 base pairs."
    },
    {
        "instruction": "What is the origin for DEL568225?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL568225?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1131690842 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690842 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690842 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690842 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690842 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690842 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690842 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690842 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690842 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690842 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174147 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174147 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174147 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174147 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174147 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174147 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566174147 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174147 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174147 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174147 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566197747 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566197747 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566197747 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566197747 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566197747 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566197747 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566197747 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566197747 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566197747 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566197747 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593544647 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593544647 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593544647 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593544647 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593544647 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593544647 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593544647 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593544647 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593544647 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593544647 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412272 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412272 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412272 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412272 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412272 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412272 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412272 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412272 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412272 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412272 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532101 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532101 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532101 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532101 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532101 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532101 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593532101 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532101 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532101 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532101 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with DEL652514?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL652514. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL652514."
    },
    {
        "instruction": "In which chromosome is DEL652514 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL652514?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL652514, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL652514?",
        "output": "The variation length is 3514 base pairs."
    },
    {
        "instruction": "What is the origin for DEL652514?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL652514?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1593539538 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539538 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539538 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539538 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539538 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539538 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539538 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539538 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539538 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539538 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593457138 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593457138 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593457138 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593457138 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593457138 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593457138 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593457138 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593457138 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593457138 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593457138 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593529861 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593529861 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593529861 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593529861 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593529861 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593529861 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593529861 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593529861 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593529861 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593529861 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL652281?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL652281. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL652281."
    },
    {
        "instruction": "In which chromosome is DEL652281 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL652281?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL652281, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL652281?",
        "output": "The variation length is 41764 base pairs."
    },
    {
        "instruction": "What is the origin for DEL652281?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL652281?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1593434175 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434175 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434175 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434175 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434175 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434175 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593434175 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434175 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434175 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434175 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593448511 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593448511 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593448511 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593448511 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593448511 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593448511 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593448511 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593448511 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593448511 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593448511 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593454115 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593454115 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593454115 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593454115 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593454115 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593454115 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593454115 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593454115 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593454115 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593454115 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593411974 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593411974 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593411974 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593411974 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593411974 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593411974 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593411974 SNP?",
        "output": "The variation length is 32 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593411974 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593411974 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593411974 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1312883856 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1312883856 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1312883856 SNP."
    },
    {
        "instruction": "In which chromosome is RS1312883856 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1312883856 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1312883856 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1312883856 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1312883856 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1312883856 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1312883856 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593443469 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593443469 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593443469 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593443469 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593443469 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593443469 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593443469 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593443469 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593443469 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593443469 SNP?",
        "output": "The resulting gene consequence is a inframe_indel."
    },
    {
        "instruction": "Which condition is asociated with RS1593443514 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593443514 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593443514 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593443514 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593443514 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593443514 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593443514 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593443514 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593443514 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593443514 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1285629437 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1285629437 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1285629437 SNP."
    },
    {
        "instruction": "In which chromosome is RS1285629437 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1285629437 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1285629437 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1285629437 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1285629437 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1285629437 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1285629437 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS955333850 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS955333850 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS955333850 SNP."
    },
    {
        "instruction": "In which chromosome is RS955333850 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS955333850 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS955333850 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS955333850 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS955333850 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS955333850 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS955333850 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS749894411 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS749894411 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS749894411 SNP."
    },
    {
        "instruction": "In which chromosome is RS749894411 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS749894411 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS749894411 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS749894411 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS749894411 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS749894411 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS749894411 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1177544722 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1177544722 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1177544722 SNP."
    },
    {
        "instruction": "In which chromosome is RS1177544722 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1177544722 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1177544722 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1177544722 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1177544722 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1177544722 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1177544722 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1370123231 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1370123231 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1370123231 SNP."
    },
    {
        "instruction": "In which chromosome is RS1370123231 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1370123231 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1370123231 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1370123231 SNP?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for RS1370123231 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1370123231 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1370123231 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 14 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 22 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS553094345 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS553094345 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS553094345 SNP."
    },
    {
        "instruction": "In which chromosome is RS553094345 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS553094345 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS553094345 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS553094345 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS553094345 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS553094345 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS553094345 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539077 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539077 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539077 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539077 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539077 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539077 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1593539077 SNP?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539077 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539077 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539077 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539493 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539493 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539493 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539493 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539493 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539493 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539493 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539493 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539493 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539493 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DUP820580?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP820580. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP820580."
    },
    {
        "instruction": "In which chromosome is DUP820580 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP820580?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP820580, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP820580?",
        "output": "The variation length is 12396 base pairs."
    },
    {
        "instruction": "What is the origin for DUP820580?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP820580?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DEL820581?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820581. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820581."
    },
    {
        "instruction": "In which chromosome is DEL820581 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820581?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820581, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820581?",
        "output": "The variation length is 27099 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820581?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820581?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820572?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820572. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820572."
    },
    {
        "instruction": "In which chromosome is DEL820572 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820572?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820572, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820572?",
        "output": "The variation length is 359 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820572?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820572?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820569?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820569. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820569."
    },
    {
        "instruction": "In which chromosome is DEL820569 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820569?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820569, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820569?",
        "output": "The variation length is 442325 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820569?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820569?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820571?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820571. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820571."
    },
    {
        "instruction": "In which chromosome is DEL820571 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820571?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820571, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820571?",
        "output": "The variation length is 180144 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820571?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820571?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DUP820579?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP820579. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP820579."
    },
    {
        "instruction": "In which chromosome is DUP820579 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP820579?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP820579, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP820579?",
        "output": "The variation length is 12400 base pairs."
    },
    {
        "instruction": "What is the origin for DUP820579?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP820579?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DEL820574?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820574. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820574."
    },
    {
        "instruction": "In which chromosome is DEL820574 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820574?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820574, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820574?",
        "output": "The variation length is 176371 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820574?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820574?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820573?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820573. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820573."
    },
    {
        "instruction": "In which chromosome is DEL820573 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820573?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820573, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820573?",
        "output": "The variation length is 109196 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820573?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820573?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820570?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820570. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820570."
    },
    {
        "instruction": "In which chromosome is DEL820570 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820570?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820570, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820570?",
        "output": "The variation length is 439162 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820570?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820570?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1949433098 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433098 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433098 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433098 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433098 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433098 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949433098 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433098 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433098 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433098 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948522929 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948522929 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948522929 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948522929 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948522929 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948522929 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948522929 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948522929 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948522929 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948522929 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949505926 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949505926 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949505926 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949505926 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949505926 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949505926 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949505926 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949505926 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949505926 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949505926 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952455844 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952455844 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952455844 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952455844 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952455844 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952455844 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952455844 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952455844 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952455844 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952455844 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949419453 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949419453 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949419453 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949419453 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949419453 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949419453 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949419453 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949419453 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949419453 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949419453 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952053203 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952053203 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952053203 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952053203 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952053203 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952053203 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952053203 SNP?",
        "output": "The variation length is 13 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952053203 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952053203 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952053203 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050268 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050268 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050268 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050268 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050268 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050268 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050268 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050268 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050268 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050268 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952481401 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952481401 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952481401 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952481401 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952481401 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952481401 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952481401 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952481401 SNP?",
        "output": "The origin is de novo."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952481401 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952481401 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1949338513 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949338513 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949338513 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949338513 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949338513 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949338513 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949338513 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949338513 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949338513 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949338513 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359603 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359603 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359603 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359603 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359603 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS1949359603 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949359603 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359603 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359603 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359603 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1949384403 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384403 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384403 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384403 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384403 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS1949384403 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949384403 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384403 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384403 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384403 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048360?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048360. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048360."
    },
    {
        "instruction": "In which chromosome is SNV1048360 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048360?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048360, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048360?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048360?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048360?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048360?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1052625?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1052625. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1052625."
    },
    {
        "instruction": "In which chromosome is DEL1052625 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1052625?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DEL1052625, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1052625?",
        "output": "The variation length is 7 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1052625?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1052625?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1052625?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1052626?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1052626. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1052626."
    },
    {
        "instruction": "In which chromosome is SNV1052626 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1052626?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV1052626, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1052626?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1052626?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1052626?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1052626?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1052627?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1052627. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1052627."
    },
    {
        "instruction": "In which chromosome is SNV1052627 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1052627?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV1052627, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1052627?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1052627?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1052627?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1052627?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1056155?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1056155. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1056155."
    },
    {
        "instruction": "In which chromosome is DEL1056155 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1056155?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1056155, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1056155?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1056155?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1056155?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1062988?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062988. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062988."
    },
    {
        "instruction": "In which chromosome is SNV1062988 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062988?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062988, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062988?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062988?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062988?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062988?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DEL1057629?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1057629. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1057629."
    },
    {
        "instruction": "In which chromosome is DEL1057629 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1057629?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1057629, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1057629?",
        "output": "The variation length is 176357 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1057629?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1057629?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1062987?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062987. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062987."
    },
    {
        "instruction": "In which chromosome is DEL1062987 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062987?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062987, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062987?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062987?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062987?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062987?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1062993?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062993. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062993."
    },
    {
        "instruction": "In which chromosome is DEL1062993 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062993?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062993, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062993?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062993?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062993?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062993?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1057630?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1057630. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1057630."
    },
    {
        "instruction": "In which chromosome is DEL1057630 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1057630?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1057630, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1057630?",
        "output": "The variation length is 41307 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1057630?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1057630?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DUP983595?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP983595. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP983595."
    },
    {
        "instruction": "In which chromosome is DUP983595 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP983595?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DUP983595, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP983595?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DUP983595?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP983595?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP983595?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP983596?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP983596. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP983596."
    },
    {
        "instruction": "In which chromosome is DUP983596 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP983596?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DUP983596, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP983596?",
        "output": "The variation length is 11 base pairs."
    },
    {
        "instruction": "What is the origin for DUP983596?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP983596?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP983596?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL983588?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL983588. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL983588."
    },
    {
        "instruction": "In which chromosome is DEL983588 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL983588?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DEL983588, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL983588?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL983588?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL983588?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL983588?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with IND983589?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND983589. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND983589."
    },
    {
        "instruction": "In which chromosome is IND983589 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND983589?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of IND983589, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for IND983589?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for IND983589?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND983589?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for IND983589?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983602?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983602. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983602."
    },
    {
        "instruction": "In which chromosome is SNV983602 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983602?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV983602, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983602?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983602?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983602?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983602?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with IND983582?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND983582. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND983582."
    },
    {
        "instruction": "In which chromosome is IND983582 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND983582?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of IND983582, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for IND983582?",
        "output": "The variation length is None base pairs."
    },
    {
        "instruction": "What is the origin for IND983582?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND983582?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "Which condition is asociated with 983601?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs983601. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/983601."
    },
    {
        "instruction": "In which chromosome is 983601 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 983601?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of 983601, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 983601?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for 983601?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 983601?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 983601?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983594?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983594. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983594."
    },
    {
        "instruction": "In which chromosome is SNV983594 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983594?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV983594, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983594?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983594?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983594?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983594?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DUP983590?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP983590. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP983590."
    },
    {
        "instruction": "In which chromosome is DUP983590 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP983590?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DUP983590, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP983590?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP983590?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP983590?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP983590?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL983587?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL983587. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL983587."
    },
    {
        "instruction": "In which chromosome is DEL983587 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL983587?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DEL983587, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL983587?",
        "output": "The variation length is 18 base pairs."
    },
    {
        "instruction": "What is the origin for DEL983587?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL983587?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL983597?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL983597. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL983597."
    },
    {
        "instruction": "In which chromosome is DEL983597 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL983597?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of DEL983597, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL983597?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for DEL983597?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL983597?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL983597?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983598?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983598. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983598."
    },
    {
        "instruction": "In which chromosome is SNV983598 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983598?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV983598, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983598?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983598?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983598?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983598?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with INS1166991?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsINS1166991. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/INS1166991."
    },
    {
        "instruction": "In which chromosome is INS1166991 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the INS1166991?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of INS1166991, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for INS1166991?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for INS1166991?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for INS1166991?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for INS1166991?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1166993?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1166993. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1166993."
    },
    {
        "instruction": "In which chromosome is DEL1166993 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1166993?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1166993, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1166993?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1166993?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1166993?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1166993?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1166994?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1166994. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1166994."
    },
    {
        "instruction": "In which chromosome is DUP1166994 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1166994?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1166994, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1166994?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1166994?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1166994?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1166994?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1166995?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1166995. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1166995."
    },
    {
        "instruction": "In which chromosome is DUP1166995 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1166995?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1166995, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1166995?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1166995?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1166995?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1166995?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1166997?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1166997. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1166997."
    },
    {
        "instruction": "In which chromosome is DEL1166997 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1166997?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1166997, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1166997?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1166997?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1166997?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1166997?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1166998?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1166998. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1166998."
    },
    {
        "instruction": "In which chromosome is DUP1166998 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1166998?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1166998, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1166998?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1166998?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1166998?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1166998?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with INS1166999?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsINS1166999. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/INS1166999."
    },
    {
        "instruction": "In which chromosome is INS1166999 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the INS1166999?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of INS1166999, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for INS1166999?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for INS1166999?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for INS1166999?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for INS1166999?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1167000?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1167000. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1167000."
    },
    {
        "instruction": "In which chromosome is DEL1167000 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1167000?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1167000, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1167000?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1167000?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1167000?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1167000?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DUP1174971?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1174971. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1174971."
    },
    {
        "instruction": "In which chromosome is DUP1174971 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1174971?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1174971, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1174971?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1174971?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1174971?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1174971?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1317600?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1317600. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1317600."
    },
    {
        "instruction": "In which chromosome is SNV1317600 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1317600?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1317600, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1317600?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1317600?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1317600?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1317600?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1370733?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1370733. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1370733."
    },
    {
        "instruction": "In which chromosome is DEL1370733 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1370733?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1370733, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1370733?",
        "output": "The variation length is 92 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1370733?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1370733?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1370733?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1442706?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1442706. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1442706."
    },
    {
        "instruction": "In which chromosome is SNV1442706 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1442706?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1442706, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1442706?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1442706?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1442706?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1442706?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with IND1501625?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND1501625. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND1501625."
    },
    {
        "instruction": "In which chromosome is IND1501625 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND1501625?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of IND1501625, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for IND1501625?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for IND1501625?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND1501625?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for IND1501625?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1615023?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1615023. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1615023."
    },
    {
        "instruction": "In which chromosome is SNV1615023 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1615023?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1615023, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1615023?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1615023?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1615023?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1615023?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1520580?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1520580. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1520580."
    },
    {
        "instruction": "In which chromosome is SNV1520580 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1520580?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1520580, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1520580?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1520580?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1520580?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1520580?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1706443?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1706443. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1706443."
    },
    {
        "instruction": "In which chromosome is SNV1706443 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1706443?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1706443, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1706443?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1706443?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1706443?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1706443?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778849 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778849 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778849 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778849 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778849 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778849 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778849 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778849 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778849 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778849 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593457065 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593457065 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593457065 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593457065 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593457065 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593457065 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593457065 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593457065 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593457065 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593457065 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1948534542 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948534542 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948534542 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948534542 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948534542 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948534542 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948534542 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948534542 SNP?",
        "output": "The origin is maternal."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948534542 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948534542 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1131690891 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690891 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690891 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690891 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690891 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690891 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690891 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690891 SNP?",
        "output": "The origin is de novo."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690891 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690891 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952715820 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952715820 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952715820 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952715820 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952715820 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952715820 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952715820 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952715820 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952715820 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952715820 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593539386 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539386 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539386 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539386 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539386 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS1593539386 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539386 SNP?",
        "output": "The variation length is 22 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539386 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539386 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539386 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with SNV1324868?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1324868. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1324868."
    },
    {
        "instruction": "In which chromosome is SNV1324868 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1324868?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1324868, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1324868?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1324868?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1324868?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1324868?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1012377281 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1012377281 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1012377281 SNP."
    },
    {
        "instruction": "In which chromosome is RS1012377281 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1012377281 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1012377281 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1012377281 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1012377281 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1012377281 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1012377281 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194400 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194400 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194400 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194400 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194400 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194400 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194400 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194400 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194400 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194400 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555283670 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555283670 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555283670 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555283670 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555283670 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555283670 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555283670 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555283670 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555283670 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555283670 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1949430616 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949430616 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949430616 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949430616 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949430616 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949430616 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949430616 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949430616 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949430616 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949430616 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913297 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913297 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913297 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913297 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913297 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS121913297 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913297 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913297 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913297 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913297 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1691098?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1691098. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1691098."
    },
    {
        "instruction": "In which chromosome is SNV1691098 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1691098?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1691098, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1691098?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1691098?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1691098?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1691098?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1691139?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1691139. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1691139."
    },
    {
        "instruction": "In which chromosome is SNV1691139 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1691139?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1691139, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1691139?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1691139?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1691139?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1691139?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1691303?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1691303. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1691303."
    },
    {
        "instruction": "In which chromosome is SNV1691303 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1691303?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1691303, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1691303?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1691303?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1691303?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1691303?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1131690859 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690859 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690859 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690859 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690859 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690859 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690859 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690859 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690859 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690859 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1860317?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1860317. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1860317."
    },
    {
        "instruction": "In which chromosome is SNV1860317 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1860317?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1860317, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1860317?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1860317?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1860317?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1860317?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1683998?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1683998. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1683998."
    },
    {
        "instruction": "In which chromosome is SNV1683998 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1683998?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1683998, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1683998?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1683998?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1683998?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1683998?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092891 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092891 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092891 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092891 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092891 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS3092891 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS3092891 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092891 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092891 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092891 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS137853296 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853296 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853296 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853296 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853296 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853296 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS137853296 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853296 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853296 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853296 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853297 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853297 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853297 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853297 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853297 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853297 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS137853297 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853297 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853297 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853297 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778864 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778864 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778864 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778864 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778864 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778864 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778864 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778864 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778864 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778864 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913305 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913305 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913305 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913305 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913305 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913305 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913305 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913305 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913305 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913305 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913296 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913296 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913296 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913296 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913296 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS121913296 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913296 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913296 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913296 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913296 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778870 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778870 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778870 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778870 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778870 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778870 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778870 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778870 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778870 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778870 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778852 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778852 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778852 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778852 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778852 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778852 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778852 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778852 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778852 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778852 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778869 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778869 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778869 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778869 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778869 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778869 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778869 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778869 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778869 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778869 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913303 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913303 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913303 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913303 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913303 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913303 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913303 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913303 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913303 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913303 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913304 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913304 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913304 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913304 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913304 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS121913304 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913304 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913304 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913304 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913304 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS878853947 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853947 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853947 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853947 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853947 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853947 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS878853947 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853947 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853947 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853947 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS528218090 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS528218090 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS528218090 SNP."
    },
    {
        "instruction": "In which chromosome is RS528218090 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS528218090 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS528218090 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS528218090 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS528218090 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS528218090 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS528218090 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS754589578 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS754589578 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS754589578 SNP."
    },
    {
        "instruction": "In which chromosome is RS754589578 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS754589578 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS754589578 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS754589578 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS754589578 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS754589578 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS754589578 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS376886420 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS376886420 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS376886420 SNP."
    },
    {
        "instruction": "In which chromosome is RS376886420 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS376886420 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS376886420 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS376886420 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS376886420 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS376886420 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS376886420 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS878853952 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853952 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853952 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853952 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853952 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853952 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS878853952 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853952 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853952 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853952 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS878853950 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853950 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853950 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853950 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853950 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853950 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS878853950 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853950 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853950 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853950 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS748093967 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS748093967 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS748093967 SNP."
    },
    {
        "instruction": "In which chromosome is RS748093967 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS748093967 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS748093967 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS748093967 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS748093967 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS748093967 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS748093967 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS367578442 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367578442 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367578442 SNP."
    },
    {
        "instruction": "In which chromosome is RS367578442 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367578442 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367578442 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS367578442 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367578442 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367578442 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367578442 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS374157786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS374157786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS374157786 SNP."
    },
    {
        "instruction": "In which chromosome is RS374157786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS374157786 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS374157786 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS374157786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS374157786 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS374157786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS374157786 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS183417081 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS183417081 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS183417081 SNP."
    },
    {
        "instruction": "In which chromosome is RS183417081 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS183417081 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS183417081 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS183417081 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS183417081 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS183417081 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS183417081 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS878853948 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853948 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853948 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853948 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853948 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853948 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS878853948 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853948 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853948 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853948 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS367960214 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367960214 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367960214 SNP."
    },
    {
        "instruction": "In which chromosome is RS367960214 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367960214 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367960214 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS367960214 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367960214 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367960214 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367960214 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS878853951 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853951 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853951 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853951 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853951 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853951 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS878853951 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853951 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853951 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853951 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS878853949 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS878853949 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS878853949 SNP."
    },
    {
        "instruction": "In which chromosome is RS878853949 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS878853949 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS878853949 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS878853949 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS878853949 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS878853949 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS878853949 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913298 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913298 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913298 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913298 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913298 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913298 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913298 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913298 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913298 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913298 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS751870680 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751870680 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751870680 SNP."
    },
    {
        "instruction": "In which chromosome is RS751870680 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751870680 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751870680 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS751870680 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751870680 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751870680 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751870680 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286707 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286707 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286707 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286707 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286707 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286707 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286707 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286707 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286707 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286707 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS779045727 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS779045727 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS779045727 SNP."
    },
    {
        "instruction": "In which chromosome is RS779045727 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS779045727 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS779045727 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS779045727 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS779045727 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS779045727 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS779045727 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS765386327 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS765386327 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS765386327 SNP."
    },
    {
        "instruction": "In which chromosome is RS765386327 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS765386327 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS765386327 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS765386327 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS765386327 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS765386327 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS765386327 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS201562657 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201562657 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201562657 SNP."
    },
    {
        "instruction": "In which chromosome is RS201562657 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201562657 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201562657 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS201562657 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201562657 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201562657 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201562657 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS745767704 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS745767704 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS745767704 SNP."
    },
    {
        "instruction": "In which chromosome is RS745767704 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS745767704 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS745767704 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS745767704 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS745767704 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS745767704 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS745767704 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503084 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503084 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503084 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503084 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503084 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503084 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503084 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503084 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503084 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503084 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503081 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503081 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503081 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503081 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503081 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503081 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503081 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503081 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503081 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503081 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503076 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503076 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503076 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503076 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503076 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503076 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503076 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503076 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503076 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503076 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503085 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503085 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503085 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503085 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503085 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503085 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503085 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503085 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503085 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503085 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1064792974 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1064792974 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1064792974 SNP."
    },
    {
        "instruction": "In which chromosome is RS1064792974 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1064792974 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1064792974 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1064792974 SNP?",
        "output": "The variation length is 29 base pairs."
    },
    {
        "instruction": "What is the origin for RS1064792974 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1064792974 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1064792974 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS949077145 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS949077145 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS949077145 SNP."
    },
    {
        "instruction": "In which chromosome is RS949077145 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS949077145 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS949077145 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS949077145 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS949077145 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS949077145 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS949077145 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS578226820 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS578226820 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS578226820 SNP."
    },
    {
        "instruction": "In which chromosome is RS578226820 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS578226820 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS578226820 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS578226820 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS578226820 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS578226820 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS578226820 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS371150038 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371150038 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371150038 SNP."
    },
    {
        "instruction": "In which chromosome is RS371150038 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371150038 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371150038 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS371150038 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371150038 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371150038 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371150038 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS9535023 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS9535023 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS9535023 SNP."
    },
    {
        "instruction": "In which chromosome is RS9535023 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS9535023 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS9535023 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS9535023 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS9535023 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS9535023 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS9535023 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS200501806 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200501806 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200501806 SNP."
    },
    {
        "instruction": "In which chromosome is RS200501806 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200501806 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200501806 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS200501806 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200501806 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200501806 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200501806 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503078 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503078 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503078 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503078 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503078 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503078 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1060503078 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503078 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503078 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503078 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS483352690 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS483352690 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS483352690 SNP."
    },
    {
        "instruction": "In which chromosome is RS483352690 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS483352690 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS483352690 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS483352690 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS483352690 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS483352690 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS483352690 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS187912365 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS187912365 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS187912365 SNP."
    },
    {
        "instruction": "In which chromosome is RS187912365 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS187912365 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS187912365 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS187912365 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS187912365 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS187912365 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS187912365 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS765277265 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS765277265 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS765277265 SNP."
    },
    {
        "instruction": "In which chromosome is RS765277265 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS765277265 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS765277265 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS765277265 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS765277265 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS765277265 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS765277265 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS767011440 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS767011440 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS767011440 SNP."
    },
    {
        "instruction": "In which chromosome is RS767011440 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS767011440 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS767011440 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS767011440 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS767011440 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS767011440 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS767011440 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503067 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503067 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503067 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503067 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503067 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503067 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503067 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503067 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503067 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503067 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS776175164 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776175164 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776175164 SNP."
    },
    {
        "instruction": "In which chromosome is RS776175164 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776175164 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776175164 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS776175164 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776175164 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776175164 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776175164 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS776162179 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776162179 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776162179 SNP."
    },
    {
        "instruction": "In which chromosome is RS776162179 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776162179 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776162179 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS776162179 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776162179 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776162179 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776162179 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503077 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503077 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503077 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503077 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503077 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503077 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503077 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503077 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503077 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503077 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1060503086 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503086 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503086 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503086 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503086 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503086 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1060503086 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503086 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503086 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503086 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503079 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503079 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503079 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503079 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503079 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503079 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503079 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503079 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503079 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503079 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1060503088 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503088 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503088 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503088 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503088 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503088 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503088 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503088 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503088 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503088 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503090 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503090 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503090 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503090 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503090 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503090 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503090 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503090 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503090 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503090 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS141608408 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS141608408 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS141608408 SNP."
    },
    {
        "instruction": "In which chromosome is RS141608408 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS141608408 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS141608408 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS141608408 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS141608408 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS141608408 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS141608408 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS759465865 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS759465865 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS759465865 SNP."
    },
    {
        "instruction": "In which chromosome is RS759465865 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS759465865 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS759465865 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS759465865 SNP?",
        "output": "The variation length is 9 base pairs."
    },
    {
        "instruction": "What is the origin for RS759465865 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS759465865 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS759465865 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS530961288 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS530961288 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS530961288 SNP."
    },
    {
        "instruction": "In which chromosome is RS530961288 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS530961288 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS530961288 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS530961288 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS530961288 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS530961288 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS530961288 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS752607904 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS752607904 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS752607904 SNP."
    },
    {
        "instruction": "In which chromosome is RS752607904 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS752607904 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS752607904 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS752607904 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS752607904 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS752607904 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS752607904 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS770100636 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770100636 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770100636 SNP."
    },
    {
        "instruction": "In which chromosome is RS770100636 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770100636 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770100636 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS770100636 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770100636 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770100636 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770100636 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503083 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503083 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503083 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503083 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503083 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503083 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503083 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503083 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503083 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503083 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS751560923 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751560923 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751560923 SNP."
    },
    {
        "instruction": "In which chromosome is RS751560923 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751560923 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751560923 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS751560923 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751560923 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751560923 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751560923 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778637 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778637 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778637 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778637 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778637 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778637 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS587778637 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778637 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778637 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778637 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1208736713 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1208736713 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1208736713 SNP."
    },
    {
        "instruction": "In which chromosome is RS1208736713 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1208736713 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1208736713 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1208736713 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1208736713 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1208736713 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1208736713 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286687 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286687 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286687 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286687 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286687 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286687 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555286687 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286687 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286687 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286687 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279227 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279227 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279227 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279227 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279227 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279227 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555279227 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279227 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279227 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279227 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS530961288 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS530961288 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS530961288 SNP."
    },
    {
        "instruction": "In which chromosome is RS530961288 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS530961288 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS530961288 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS530961288 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS530961288 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS530961288 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS530961288 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS745822791 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS745822791 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS745822791 SNP."
    },
    {
        "instruction": "In which chromosome is RS745822791 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS745822791 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS745822791 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS745822791 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS745822791 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS745822791 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS745822791 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS759311626 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS759311626 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS759311626 SNP."
    },
    {
        "instruction": "In which chromosome is RS759311626 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS759311626 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS759311626 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS759311626 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS759311626 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS759311626 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS759311626 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS754507551 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS754507551 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS754507551 SNP."
    },
    {
        "instruction": "In which chromosome is RS754507551 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS754507551 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS754507551 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS754507551 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS754507551 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS754507551 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS754507551 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1276641790 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1276641790 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1276641790 SNP."
    },
    {
        "instruction": "In which chromosome is RS1276641790 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1276641790 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1276641790 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1276641790 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1276641790 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1276641790 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1276641790 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS776531398 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776531398 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776531398 SNP."
    },
    {
        "instruction": "In which chromosome is RS776531398 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776531398 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776531398 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS776531398 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776531398 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776531398 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776531398 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555293654 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555293654 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555293654 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555293654 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555293654 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555293654 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555293654 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555293654 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555293654 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555293654 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1419550675 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1419550675 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1419550675 SNP."
    },
    {
        "instruction": "In which chromosome is RS1419550675 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1419550675 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1419550675 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1419550675 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1419550675 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1419550675 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1419550675 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1340503453 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1340503453 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1340503453 SNP."
    },
    {
        "instruction": "In which chromosome is RS1340503453 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1340503453 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1340503453 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1340503453 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1340503453 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1340503453 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1340503453 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS748635133 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS748635133 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS748635133 SNP."
    },
    {
        "instruction": "In which chromosome is RS748635133 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS748635133 SNP?",
        "output": "Associated methods are: phenotyping only, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS748635133 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS748635133 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS748635133 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS748635133 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS748635133 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1012377281 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1012377281 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1012377281 SNP."
    },
    {
        "instruction": "In which chromosome is RS1012377281 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1012377281 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1012377281 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1012377281 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1012377281 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1012377281 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1012377281 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS190689977 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS190689977 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS190689977 SNP."
    },
    {
        "instruction": "In which chromosome is RS190689977 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS190689977 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS190689977 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS190689977 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS190689977 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS190689977 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS190689977 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1447082021 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1447082021 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1447082021 SNP."
    },
    {
        "instruction": "In which chromosome is RS1447082021 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1447082021 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1447082021 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1447082021 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1447082021 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1447082021 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1447082021 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286611 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286611 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286611 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286611 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286611 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286611 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286611 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286611 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286611 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286611 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294518 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294518 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294518 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294518 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294518 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294518 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555294518 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294518 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294518 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294518 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1461167778 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1461167778 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1461167778 SNP."
    },
    {
        "instruction": "In which chromosome is RS1461167778 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1461167778 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1461167778 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1461167778 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1461167778 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1461167778 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1461167778 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555282772 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555282772 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555282772 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555282772 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555282772 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555282772 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555282772 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555282772 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555282772 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555282772 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS922948338 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS922948338 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS922948338 SNP."
    },
    {
        "instruction": "In which chromosome is RS922948338 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS922948338 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS922948338 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS922948338 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS922948338 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS922948338 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS922948338 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286236 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286236 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286236 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286236 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286236 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286236 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286236 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286236 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286236 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286236 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS749392116 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS749392116 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS749392116 SNP."
    },
    {
        "instruction": "In which chromosome is RS749392116 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS749392116 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS749392116 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS749392116 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS749392116 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS749392116 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS749392116 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555293625 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555293625 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555293625 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555293625 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555293625 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555293625 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555293625 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555293625 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555293625 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555293625 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS761609284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761609284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761609284 SNP."
    },
    {
        "instruction": "In which chromosome is RS761609284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761609284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761609284 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS761609284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761609284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761609284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761609284 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555282792 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555282792 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555282792 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555282792 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555282792 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555282792 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555282792 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555282792 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555282792 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555282792 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS752334972 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS752334972 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS752334972 SNP."
    },
    {
        "instruction": "In which chromosome is RS752334972 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS752334972 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS752334972 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS752334972 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS752334972 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS752334972 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS752334972 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS759188465 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS759188465 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS759188465 SNP."
    },
    {
        "instruction": "In which chromosome is RS759188465 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS759188465 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS759188465 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS759188465 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS759188465 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS759188465 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS759188465 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS757275103 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS757275103 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS757275103 SNP."
    },
    {
        "instruction": "In which chromosome is RS757275103 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS757275103 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS757275103 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS757275103 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS757275103 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS757275103 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS757275103 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1195873978 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1195873978 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1195873978 SNP."
    },
    {
        "instruction": "In which chromosome is RS1195873978 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1195873978 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1195873978 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1195873978 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1195873978 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1195873978 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1195873978 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS538578527 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS538578527 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS538578527 SNP."
    },
    {
        "instruction": "In which chromosome is RS538578527 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS538578527 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS538578527 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS538578527 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS538578527 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS538578527 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS538578527 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS781780669 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS781780669 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS781780669 SNP."
    },
    {
        "instruction": "In which chromosome is RS781780669 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS781780669 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS781780669 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS781780669 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS781780669 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS781780669 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS781780669 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS755688480 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS755688480 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS755688480 SNP."
    },
    {
        "instruction": "In which chromosome is RS755688480 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS755688480 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS755688480 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS755688480 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS755688480 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS755688480 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS755688480 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690863 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690863 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690863 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690863 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690863 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690863 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690863 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690863 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690863 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690863 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1555286676 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286676 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286676 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286676 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286676 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286676 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555286676 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286676 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286676 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286676 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS763525092 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS763525092 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS763525092 SNP."
    },
    {
        "instruction": "In which chromosome is RS763525092 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS763525092 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS763525092 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS763525092 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS763525092 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS763525092 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS763525092 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS780248969 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780248969 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780248969 SNP."
    },
    {
        "instruction": "In which chromosome is RS780248969 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780248969 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780248969 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS780248969 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS780248969 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780248969 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780248969 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS764472420 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS764472420 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS764472420 SNP."
    },
    {
        "instruction": "In which chromosome is RS764472420 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS764472420 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS764472420 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS764472420 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS764472420 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS764472420 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS764472420 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1347755761 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1347755761 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1347755761 SNP."
    },
    {
        "instruction": "In which chromosome is RS1347755761 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1347755761 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1347755761 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1347755761 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1347755761 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1347755761 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1347755761 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286684 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286684 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286684 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286684 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286684 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286684 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555286684 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286684 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286684 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286684 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555283680 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555283680 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555283680 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555283680 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555283680 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555283680 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555283680 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555283680 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555283680 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555283680 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286700 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286700 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286700 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286700 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286700 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286700 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555286700 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286700 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286700 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286700 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS144668210 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS144668210 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS144668210 SNP."
    },
    {
        "instruction": "In which chromosome is RS144668210 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS144668210 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS144668210 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS144668210 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS144668210 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS144668210 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS144668210 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279212 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279212 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279212 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279212 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279212 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279212 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555279212 SNP?",
        "output": "The variation length is 20 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279212 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279212 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279212 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294628 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294628 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294628 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294628 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294628 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294628 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555294628 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294628 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294628 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294628 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555283135 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555283135 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555283135 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555283135 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555283135 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555283135 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555283135 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555283135 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555283135 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555283135 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS190689977 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS190689977 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS190689977 SNP."
    },
    {
        "instruction": "In which chromosome is RS190689977 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS190689977 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS190689977 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS190689977 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS190689977 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS190689977 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS190689977 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555284956 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555284956 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555284956 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555284956 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555284956 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555284956 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555284956 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555284956 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555284956 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555284956 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555293637 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555293637 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555293637 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555293637 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555293637 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555293637 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555293637 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555293637 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555293637 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555293637 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS991505835 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS991505835 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS991505835 SNP."
    },
    {
        "instruction": "In which chromosome is RS991505835 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS991505835 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS991505835 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS991505835 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS991505835 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS991505835 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS991505835 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1273298763 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1273298763 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1273298763 SNP."
    },
    {
        "instruction": "In which chromosome is RS1273298763 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1273298763 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1273298763 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1273298763 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1273298763 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1273298763 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1273298763 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS554727080 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS554727080 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS554727080 SNP."
    },
    {
        "instruction": "In which chromosome is RS554727080 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS554727080 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS554727080 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS554727080 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS554727080 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS554727080 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS554727080 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555295597 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555295597 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555295597 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555295597 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555295597 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555295597 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555295597 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555295597 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555295597 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555295597 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294098 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294098 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294098 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294098 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294098 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294098 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555294098 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294098 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294098 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294098 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS770860809 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770860809 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770860809 SNP."
    },
    {
        "instruction": "In which chromosome is RS770860809 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770860809 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770860809 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS770860809 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770860809 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770860809 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770860809 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS752897010 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS752897010 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS752897010 SNP."
    },
    {
        "instruction": "In which chromosome is RS752897010 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS752897010 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS752897010 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS752897010 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS752897010 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS752897010 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS752897010 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS758187955 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS758187955 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS758187955 SNP."
    },
    {
        "instruction": "In which chromosome is RS758187955 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS758187955 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS758187955 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS758187955 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS758187955 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS758187955 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS758187955 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776787 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776787 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776787 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776787 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776787 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587776787 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776787 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776787 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776787 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776787 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286598 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286598 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286598 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286598 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286598 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286598 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555286598 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286598 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286598 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286598 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555285117 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555285117 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555285117 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555285117 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555285117 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555285117 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555285117 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555285117 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555285117 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555285117 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279223 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279223 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279223 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279223 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279223 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279223 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555279223 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279223 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279223 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279223 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS896487590 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS896487590 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS896487590 SNP."
    },
    {
        "instruction": "In which chromosome is RS896487590 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS896487590 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS896487590 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS896487590 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS896487590 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS896487590 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS896487590 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279518 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279518 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279518 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279518 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279518 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279518 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555279518 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279518 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279518 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279518 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555282811 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555282811 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555282811 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555282811 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555282811 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555282811 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555282811 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555282811 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555282811 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555282811 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555283482 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555283482 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555283482 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555283482 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555283482 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555283482 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555283482 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555283482 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555283482 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555283482 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS139673557 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS139673557 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS139673557 SNP."
    },
    {
        "instruction": "In which chromosome is RS139673557 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS139673557 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS139673557 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS139673557 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS139673557 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS139673557 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS139673557 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS778503152 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS778503152 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS778503152 SNP."
    },
    {
        "instruction": "In which chromosome is RS778503152 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS778503152 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS778503152 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS778503152 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS778503152 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS778503152 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS778503152 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294626 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294626 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294626 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294626 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294626 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294626 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555294626 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294626 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294626 SNP?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "Which condition is asociated with RS1555286220 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286220 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286220 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286220 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286220 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286220 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286220 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286220 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286220 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286220 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1180053508 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1180053508 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1180053508 SNP."
    },
    {
        "instruction": "In which chromosome is RS1180053508 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1180053508 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1180053508 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1180053508 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1180053508 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1180053508 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1180053508 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294601 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294601 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294601 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294601 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294601 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294601 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555294601 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294601 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294601 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294601 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286695 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286695 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286695 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286695 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286695 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286695 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286695 SNP?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286695 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286695 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286695 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS761999108 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761999108 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761999108 SNP."
    },
    {
        "instruction": "In which chromosome is RS761999108 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761999108 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761999108 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS761999108 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761999108 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761999108 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761999108 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555285148 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555285148 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555285148 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555285148 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555285148 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555285148 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555285148 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555285148 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555285148 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555285148 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS535576919 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS535576919 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS535576919 SNP."
    },
    {
        "instruction": "In which chromosome is RS535576919 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS535576919 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS535576919 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS535576919 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS535576919 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS535576919 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS535576919 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286250 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286250 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286250 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286250 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286250 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286250 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286250 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286250 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286250 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286250 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS897199998 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS897199998 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS897199998 SNP."
    },
    {
        "instruction": "In which chromosome is RS897199998 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS897199998 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS897199998 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS897199998 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS897199998 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS897199998 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS897199998 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555293835 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555293835 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555293835 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555293835 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555293835 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555293835 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555293835 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555293835 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555293835 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555293835 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555282783 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555282783 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555282783 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555282783 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555282783 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555282783 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555282783 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555282783 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555282783 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555282783 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS371031574 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371031574 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371031574 SNP."
    },
    {
        "instruction": "In which chromosome is RS371031574 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371031574 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371031574 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS371031574 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371031574 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371031574 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371031574 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS529366765 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS529366765 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS529366765 SNP."
    },
    {
        "instruction": "In which chromosome is RS529366765 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS529366765 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS529366765 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS529366765 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS529366765 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS529366765 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS529366765 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS898303682 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS898303682 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS898303682 SNP."
    },
    {
        "instruction": "In which chromosome is RS898303682 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS898303682 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS898303682 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS898303682 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS898303682 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS898303682 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS898303682 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555295331 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555295331 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555295331 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555295331 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555295331 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555295331 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555295331 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555295331 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555295331 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555295331 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS121913297 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913297 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913297 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913297 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913297 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS121913297 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS121913297 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913297 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913297 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913297 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS899323337 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS899323337 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS899323337 SNP."
    },
    {
        "instruction": "In which chromosome is RS899323337 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS899323337 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS899323337 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS899323337 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS899323337 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS899323337 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS899323337 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1220347917 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1220347917 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1220347917 SNP."
    },
    {
        "instruction": "In which chromosome is RS1220347917 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1220347917 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1220347917 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1220347917 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1220347917 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1220347917 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1220347917 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555295354 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555295354 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555295354 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555295354 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555295354 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555295354 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555295354 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555295354 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555295354 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555295354 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1254191370 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1254191370 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1254191370 SNP."
    },
    {
        "instruction": "In which chromosome is RS1254191370 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1254191370 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1254191370 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1254191370 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1254191370 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1254191370 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1254191370 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS747518543 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS747518543 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS747518543 SNP."
    },
    {
        "instruction": "In which chromosome is RS747518543 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS747518543 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS747518543 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS747518543 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS747518543 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS747518543 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS747518543 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS747518543 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS747518543 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS747518543 SNP."
    },
    {
        "instruction": "In which chromosome is RS747518543 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS747518543 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS747518543 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS747518543 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS747518543 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS747518543 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS747518543 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS369154092 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS369154092 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS369154092 SNP."
    },
    {
        "instruction": "In which chromosome is RS369154092 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS369154092 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS369154092 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS369154092 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS369154092 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS369154092 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS369154092 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS367654488 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367654488 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367654488 SNP."
    },
    {
        "instruction": "In which chromosome is RS367654488 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367654488 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367654488 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS367654488 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367654488 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367654488 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367654488 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1453083586 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1453083586 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1453083586 SNP."
    },
    {
        "instruction": "In which chromosome is RS1453083586 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1453083586 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1453083586 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1453083586 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1453083586 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1453083586 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1453083586 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1038764979 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1038764979 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1038764979 SNP."
    },
    {
        "instruction": "In which chromosome is RS1038764979 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1038764979 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1038764979 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1038764979 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1038764979 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1038764979 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1038764979 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555285114 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555285114 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555285114 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555285114 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555285114 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555285114 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555285114 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555285114 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555285114 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555285114 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294515 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294515 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294515 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294515 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294515 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294515 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555294515 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294515 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294515 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294515 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1351161278 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1351161278 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1351161278 SNP."
    },
    {
        "instruction": "In which chromosome is RS1351161278 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1351161278 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1351161278 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1351161278 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1351161278 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1351161278 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1351161278 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS994129583 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS994129583 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS994129583 SNP."
    },
    {
        "instruction": "In which chromosome is RS994129583 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS994129583 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS994129583 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS994129583 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS994129583 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS994129583 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS994129583 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS755417160 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS755417160 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS755417160 SNP."
    },
    {
        "instruction": "In which chromosome is RS755417160 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS755417160 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS755417160 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS755417160 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS755417160 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS755417160 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS755417160 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS150700378 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS150700378 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS150700378 SNP."
    },
    {
        "instruction": "In which chromosome is RS150700378 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS150700378 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS150700378 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS150700378 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS150700378 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS150700378 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS150700378 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1369823342 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1369823342 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1369823342 SNP."
    },
    {
        "instruction": "In which chromosome is RS1369823342 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1369823342 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1369823342 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1369823342 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1369823342 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1369823342 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1369823342 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690864 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690864 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690864 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690864 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690864 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690864 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690864 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690864 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690864 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690864 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566192557 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566192557 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566192557 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566192557 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566192557 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566192557 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566192557 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566192557 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566192557 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566192557 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194323 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194323 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194323 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194323 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194323 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194323 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566194323 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194323 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194323 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194323 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690881 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690881 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690881 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690881 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690881 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690881 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690881 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690881 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690881 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690881 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS201046651 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201046651 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201046651 SNP."
    },
    {
        "instruction": "In which chromosome is RS201046651 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201046651 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201046651 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS201046651 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201046651 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201046651 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201046651 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174074 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174074 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174074 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174074 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174074 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174074 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566174074 SNP?",
        "output": "The variation length is 26 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174074 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174074 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174074 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1366675428 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1366675428 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1366675428 SNP."
    },
    {
        "instruction": "In which chromosome is RS1366675428 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1366675428 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1366675428 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1366675428 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1366675428 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1366675428 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1366675428 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS780588550 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780588550 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780588550 SNP."
    },
    {
        "instruction": "In which chromosome is RS780588550 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780588550 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780588550 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS780588550 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS780588550 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780588550 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780588550 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566199571 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566199571 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566199571 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566199571 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566199571 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566199571 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566199571 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566199571 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566199571 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566199571 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186840 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186840 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186840 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186840 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186840 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186840 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566186840 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186840 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186840 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186840 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS773662417 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS773662417 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS773662417 SNP."
    },
    {
        "instruction": "In which chromosome is RS773662417 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS773662417 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS773662417 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS773662417 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS773662417 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS773662417 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS773662417 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1370947947 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1370947947 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1370947947 SNP."
    },
    {
        "instruction": "In which chromosome is RS1370947947 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1370947947 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1370947947 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1370947947 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1370947947 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1370947947 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1370947947 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1189153218 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1189153218 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1189153218 SNP."
    },
    {
        "instruction": "In which chromosome is RS1189153218 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1189153218 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1189153218 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1189153218 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1189153218 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1189153218 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1189153218 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1221157259 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1221157259 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1221157259 SNP."
    },
    {
        "instruction": "In which chromosome is RS1221157259 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1221157259 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1221157259 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1221157259 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1221157259 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1221157259 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1221157259 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566237790 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566237790 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566237790 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566237790 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566237790 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566237790 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566237790 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566237790 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566237790 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566237790 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566241168 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566241168 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566241168 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566241168 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566241168 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566241168 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566241168 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566241168 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566241168 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566241168 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1007286459 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1007286459 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1007286459 SNP."
    },
    {
        "instruction": "In which chromosome is RS1007286459 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1007286459 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1007286459 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1007286459 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1007286459 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1007286459 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1007286459 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS564137727 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS564137727 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS564137727 SNP."
    },
    {
        "instruction": "In which chromosome is RS564137727 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS564137727 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS564137727 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS564137727 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS564137727 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS564137727 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS564137727 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1460190600 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1460190600 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1460190600 SNP."
    },
    {
        "instruction": "In which chromosome is RS1460190600 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1460190600 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1460190600 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1460190600 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1460190600 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1460190600 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1460190600 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566235470 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566235470 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566235470 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566235470 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566235470 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566235470 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566235470 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566235470 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566235470 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566235470 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1201977804 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1201977804 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1201977804 SNP."
    },
    {
        "instruction": "In which chromosome is RS1201977804 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1201977804 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1201977804 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1201977804 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1201977804 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1201977804 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1201977804 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566191596 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566191596 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566191596 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566191596 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566191596 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566191596 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566191596 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566191596 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566191596 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566191596 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS751263356 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751263356 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751263356 SNP."
    },
    {
        "instruction": "In which chromosome is RS751263356 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751263356 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751263356 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS751263356 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751263356 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751263356 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751263356 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240970 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240970 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240970 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240970 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240970 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240970 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566240970 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240970 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240970 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240970 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566199125 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566199125 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566199125 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566199125 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566199125 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566199125 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566199125 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566199125 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566199125 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566199125 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566237098 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566237098 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566237098 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566237098 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566237098 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566237098 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566237098 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566237098 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566237098 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566237098 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194415 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194415 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194415 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194415 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194415 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194415 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566194415 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194415 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194415 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194415 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1312442837 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1312442837 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1312442837 SNP."
    },
    {
        "instruction": "In which chromosome is RS1312442837 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1312442837 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1312442837 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1312442837 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1312442837 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1312442837 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1312442837 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1273298763 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1273298763 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1273298763 SNP."
    },
    {
        "instruction": "In which chromosome is RS1273298763 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1273298763 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1273298763 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1273298763 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1273298763 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1273298763 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1273298763 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1319691084 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1319691084 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1319691084 SNP."
    },
    {
        "instruction": "In which chromosome is RS1319691084 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1319691084 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1319691084 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1319691084 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1319691084 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1319691084 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1319691084 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279210 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279210 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279210 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279210 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279210 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279210 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555279210 SNP?",
        "output": "The variation length is 23 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279210 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279210 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279210 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS769858139 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769858139 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769858139 SNP."
    },
    {
        "instruction": "In which chromosome is RS769858139 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769858139 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769858139 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS769858139 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769858139 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS769858139 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769858139 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS958914211 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS958914211 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS958914211 SNP."
    },
    {
        "instruction": "In which chromosome is RS958914211 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS958914211 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS958914211 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS958914211 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS958914211 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS958914211 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS958914211 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1232080974 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1232080974 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1232080974 SNP."
    },
    {
        "instruction": "In which chromosome is RS1232080974 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1232080974 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1232080974 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1232080974 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1232080974 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1232080974 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1232080974 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS772678500 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS772678500 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS772678500 SNP."
    },
    {
        "instruction": "In which chromosome is RS772678500 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS772678500 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS772678500 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS772678500 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS772678500 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS772678500 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS772678500 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566196458 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566196458 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566196458 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566196458 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566196458 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566196458 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566196458 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566196458 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566196458 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566196458 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1346693507 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1346693507 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1346693507 SNP."
    },
    {
        "instruction": "In which chromosome is RS1346693507 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1346693507 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1346693507 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1346693507 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1346693507 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1346693507 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1346693507 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS758494086 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS758494086 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS758494086 SNP."
    },
    {
        "instruction": "In which chromosome is RS758494086 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS758494086 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS758494086 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS758494086 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS758494086 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS758494086 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS758494086 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1444353743 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1444353743 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1444353743 SNP."
    },
    {
        "instruction": "In which chromosome is RS1444353743 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1444353743 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1444353743 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1444353743 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1444353743 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1444353743 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1444353743 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566199647 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566199647 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566199647 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566199647 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566199647 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566199647 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566199647 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566199647 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566199647 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566199647 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690851 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690851 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690851 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690851 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690851 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690851 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690851 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690851 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690851 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690851 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566192530 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566192530 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566192530 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566192530 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566192530 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566192530 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566192530 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566192530 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566192530 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566192530 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS764140783 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS764140783 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS764140783 SNP."
    },
    {
        "instruction": "In which chromosome is RS764140783 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS764140783 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS764140783 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS764140783 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS764140783 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS764140783 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS764140783 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1480581747 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1480581747 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1480581747 SNP."
    },
    {
        "instruction": "In which chromosome is RS1480581747 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1480581747 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1480581747 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1480581747 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1480581747 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1480581747 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1480581747 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240932 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240932 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240932 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240932 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240932 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240932 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566240932 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240932 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240932 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240932 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194338 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194338 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194338 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194338 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194338 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194338 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194338 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194338 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194338 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194338 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194351 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194351 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194351 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194351 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194351 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194351 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194351 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194351 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194351 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194351 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690901 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690901 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690901 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690901 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690901 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690901 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690901 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690901 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690901 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690901 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS769425649 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769425649 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769425649 SNP."
    },
    {
        "instruction": "In which chromosome is RS769425649 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769425649 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769425649 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS769425649 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769425649 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS769425649 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769425649 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566241021 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566241021 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566241021 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566241021 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566241021 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566241021 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566241021 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566241021 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566241021 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566241021 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS201285819 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201285819 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201285819 SNP."
    },
    {
        "instruction": "In which chromosome is RS201285819 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201285819 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201285819 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS201285819 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201285819 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201285819 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201285819 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503086 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503086 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503086 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503086 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503086 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503086 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503086 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503086 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503086 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503086 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS760787104 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS760787104 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS760787104 SNP."
    },
    {
        "instruction": "In which chromosome is RS760787104 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS760787104 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS760787104 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS760787104 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS760787104 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS760787104 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS760787104 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186839 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186839 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186839 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186839 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186839 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186839 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566186839 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186839 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186839 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186839 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1401332173 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1401332173 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1401332173 SNP."
    },
    {
        "instruction": "In which chromosome is RS1401332173 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1401332173 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1401332173 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1401332173 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1401332173 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1401332173 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1401332173 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1243796201 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1243796201 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1243796201 SNP."
    },
    {
        "instruction": "In which chromosome is RS1243796201 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1243796201 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1243796201 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1243796201 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1243796201 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1243796201 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1243796201 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240914 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240914 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240914 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240914 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240914 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240914 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566240914 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240914 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240914 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240914 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS373623059 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS373623059 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS373623059 SNP."
    },
    {
        "instruction": "In which chromosome is RS373623059 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS373623059 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS373623059 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS373623059 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS373623059 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS373623059 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS373623059 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS886449283 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886449283 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886449283 SNP."
    },
    {
        "instruction": "In which chromosome is RS886449283 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886449283 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886449283 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886449283 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886449283 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886449283 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886449283 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1166566395 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1166566395 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1166566395 SNP."
    },
    {
        "instruction": "In which chromosome is RS1166566395 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1166566395 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1166566395 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1166566395 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1166566395 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1166566395 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1166566395 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690908 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690908 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690908 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690908 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690908 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690908 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690908 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690908 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690908 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690908 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS769113950 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769113950 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769113950 SNP."
    },
    {
        "instruction": "In which chromosome is RS769113950 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769113950 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769113950 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS769113950 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769113950 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS769113950 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769113950 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS558114005 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS558114005 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS558114005 SNP."
    },
    {
        "instruction": "In which chromosome is RS558114005 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS558114005 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS558114005 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS558114005 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS558114005 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS558114005 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS558114005 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174063 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174063 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174063 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174063 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174063 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174063 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566174063 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174063 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174063 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174063 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS776307088 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776307088 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776307088 SNP."
    },
    {
        "instruction": "In which chromosome is RS776307088 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776307088 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776307088 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS776307088 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776307088 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776307088 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776307088 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1276653645 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1276653645 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1276653645 SNP."
    },
    {
        "instruction": "In which chromosome is RS1276653645 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1276653645 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1276653645 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1276653645 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1276653645 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1276653645 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1276653645 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174065 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174065 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174065 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174065 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174065 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174065 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566174065 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174065 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174065 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174065 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS764520289 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS764520289 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS764520289 SNP."
    },
    {
        "instruction": "In which chromosome is RS764520289 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS764520289 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS764520289 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS764520289 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS764520289 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS764520289 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS764520289 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194383 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194383 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194383 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194383 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194383 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194383 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194383 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194383 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194383 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194383 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186889 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186889 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186889 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186889 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186889 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186889 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566186889 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186889 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186889 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186889 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1555294601 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294601 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294601 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294601 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294601 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294601 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555294601 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294601 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294601 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294601 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566241180 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566241180 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566241180 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566241180 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566241180 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566241180 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566241180 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566241180 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566241180 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566241180 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1566194312 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194312 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194312 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194312 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194312 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194312 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194312 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194312 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194312 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194312 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS398123331 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS398123331 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS398123331 SNP."
    },
    {
        "instruction": "In which chromosome is RS398123331 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS398123331 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS398123331 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS398123331 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS398123331 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS398123331 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS398123331 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566235448 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566235448 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566235448 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566235448 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566235448 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566235448 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566235448 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566235448 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566235448 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566235448 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566237785 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566237785 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566237785 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566237785 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566237785 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566237785 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566237785 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566237785 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566237785 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566237785 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240940 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240940 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240940 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240940 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240940 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240940 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566240940 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240940 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240940 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240940 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593457070 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593457070 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593457070 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593457070 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593457070 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593457070 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593457070 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593457070 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593457070 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593457070 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593538220 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593538220 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593538220 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593538220 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593538220 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593538220 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593538220 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593538220 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593538220 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593538220 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593445220 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445220 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445220 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445220 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445220 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445220 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593445220 SNP?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445220 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445220 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445220 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS369755801 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS369755801 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS369755801 SNP."
    },
    {
        "instruction": "In which chromosome is RS369755801 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS369755801 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS369755801 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS369755801 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS369755801 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS369755801 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS369755801 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1453047397 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1453047397 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1453047397 SNP."
    },
    {
        "instruction": "In which chromosome is RS1453047397 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1453047397 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1453047397 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1453047397 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1453047397 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1453047397 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1453047397 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1240896329 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1240896329 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1240896329 SNP."
    },
    {
        "instruction": "In which chromosome is RS1240896329 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1240896329 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1240896329 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1240896329 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1240896329 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1240896329 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1240896329 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1462238834 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1462238834 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1462238834 SNP."
    },
    {
        "instruction": "In which chromosome is RS1462238834 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1462238834 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1462238834 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1462238834 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1462238834 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1462238834 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1462238834 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593534748 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593534748 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593534748 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593534748 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593534748 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593534748 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593534748 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593534748 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593534748 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593534748 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566194403 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566194403 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566194403 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566194403 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566194403 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566194403 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566194403 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566194403 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566194403 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566194403 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS746116477 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746116477 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746116477 SNP."
    },
    {
        "instruction": "In which chromosome is RS746116477 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746116477 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746116477 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS746116477 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS746116477 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746116477 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746116477 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1431881254 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1431881254 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1431881254 SNP."
    },
    {
        "instruction": "In which chromosome is RS1431881254 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1431881254 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1431881254 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1431881254 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1431881254 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1431881254 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1431881254 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532038 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532038 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532038 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532038 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532038 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532038 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593532038 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532038 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532038 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532038 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593538155 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593538155 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593538155 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593538155 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593538155 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593538155 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593538155 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593538155 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593538155 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593538155 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593414429 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593414429 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593414429 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593414429 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593414429 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593414429 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593414429 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593414429 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593414429 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593414429 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593435682 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593435682 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593435682 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593435682 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593435682 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593435682 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593435682 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593435682 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593435682 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593435682 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1050717570 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1050717570 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1050717570 SNP."
    },
    {
        "instruction": "In which chromosome is RS1050717570 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1050717570 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1050717570 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1050717570 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1050717570 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1050717570 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1050717570 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593414390 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593414390 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593414390 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593414390 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593414390 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593414390 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593414390 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593414390 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593414390 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593414390 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593435687 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593435687 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593435687 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593435687 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593435687 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593435687 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593435687 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593435687 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593435687 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593435687 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539225 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539225 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539225 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539225 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539225 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539225 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593539225 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539225 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539225 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539225 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539225 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539225 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539225 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539225 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539225 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539225 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539225 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539225 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539225 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539225 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS965729205 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS965729205 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS965729205 SNP."
    },
    {
        "instruction": "In which chromosome is RS965729205 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS965729205 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS965729205 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS965729205 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS965729205 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS965729205 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS965729205 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1329826610 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1329826610 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1329826610 SNP."
    },
    {
        "instruction": "In which chromosome is RS1329826610 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1329826610 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1329826610 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1329826610 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1329826610 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1329826610 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1329826610 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS528218090 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS528218090 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS528218090 SNP."
    },
    {
        "instruction": "In which chromosome is RS528218090 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS528218090 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS528218090 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS528218090 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS528218090 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS528218090 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS528218090 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532084 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532084 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532084 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532084 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532084 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532084 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593532084 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532084 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532084 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532084 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593437952 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593437952 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593437952 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593437952 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593437952 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593437952 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593437952 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593437952 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593437952 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593437952 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593456939 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593456939 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593456939 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593456939 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593456939 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593456939 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593456939 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593456939 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593456939 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593456939 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS775640888 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775640888 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775640888 SNP."
    },
    {
        "instruction": "In which chromosome is RS775640888 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775640888 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775640888 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS775640888 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775640888 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775640888 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775640888 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593456358 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593456358 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593456358 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593456358 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593456358 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593456358 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593456358 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593456358 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593456358 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593456358 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593534586 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593534586 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593534586 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593534586 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593534586 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593534586 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593534586 SNP?",
        "output": "The variation length is 19 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593534586 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593534586 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593534586 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS139960834 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS139960834 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS139960834 SNP."
    },
    {
        "instruction": "In which chromosome is RS139960834 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS139960834 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS139960834 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS139960834 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS139960834 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS139960834 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS139960834 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1360367329 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1360367329 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1360367329 SNP."
    },
    {
        "instruction": "In which chromosome is RS1360367329 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1360367329 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1360367329 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1360367329 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1360367329 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1360367329 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1360367329 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593538175 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593538175 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593538175 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593538175 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593538175 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593538175 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593538175 SNP?",
        "output": "The variation length is 8 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593538175 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593538175 SNP?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593538175 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1345893304 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1345893304 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1345893304 SNP."
    },
    {
        "instruction": "In which chromosome is RS1345893304 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1345893304 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1345893304 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1345893304 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1345893304 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1345893304 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1345893304 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1334513810 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1334513810 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1334513810 SNP."
    },
    {
        "instruction": "In which chromosome is RS1334513810 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1334513810 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1334513810 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1334513810 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1334513810 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1334513810 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1334513810 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593456963 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593456963 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593456963 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593456963 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593456963 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593456963 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593456963 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593456963 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593456963 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593456963 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1265159988 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1265159988 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1265159988 SNP."
    },
    {
        "instruction": "In which chromosome is RS1265159988 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1265159988 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1265159988 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1265159988 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1265159988 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1265159988 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1265159988 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539163 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539163 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539163 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539163 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539163 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539163 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593539163 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539163 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539163 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539163 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593445096 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445096 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445096 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445096 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445096 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445096 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593445096 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445096 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445096 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445096 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412262 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412262 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412262 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412262 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412262 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412262 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412262 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412262 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412262 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412262 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1270702085 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1270702085 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1270702085 SNP."
    },
    {
        "instruction": "In which chromosome is RS1270702085 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1270702085 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1270702085 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1270702085 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1270702085 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1270702085 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1270702085 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539435 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539435 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539435 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539435 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539435 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539435 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539435 SNP?",
        "output": "The variation length is 10 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539435 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539435 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539435 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS772362181 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS772362181 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS772362181 SNP."
    },
    {
        "instruction": "In which chromosome is RS772362181 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS772362181 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS772362181 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS772362181 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS772362181 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS772362181 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS772362181 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS768305224 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS768305224 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS768305224 SNP."
    },
    {
        "instruction": "In which chromosome is RS768305224 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS768305224 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS768305224 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS768305224 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS768305224 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS768305224 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS768305224 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS578226820 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS578226820 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS578226820 SNP."
    },
    {
        "instruction": "In which chromosome is RS578226820 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS578226820 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS578226820 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS578226820 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS578226820 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS578226820 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS578226820 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690843 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690843 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690843 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690843 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690843 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690843 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690843 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690843 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690843 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690843 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593457156 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593457156 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593457156 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593457156 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593457156 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593457156 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593457156 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593457156 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593457156 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593457156 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593435676 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593435676 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593435676 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593435676 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593435676 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593435676 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593435676 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593435676 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593435676 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593435676 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS774525913 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS774525913 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS774525913 SNP."
    },
    {
        "instruction": "In which chromosome is RS774525913 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS774525913 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS774525913 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS774525913 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS774525913 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS774525913 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS774525913 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532012 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532012 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532012 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532012 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532012 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532012 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593532012 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532012 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532012 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532012 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593457108 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593457108 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593457108 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593457108 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593457108 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593457108 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593457108 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593457108 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593457108 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593457108 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593412002 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412002 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412002 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412002 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412002 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412002 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593412002 SNP?",
        "output": "The variation length is 32 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412002 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412002 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412002 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593445172 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445172 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445172 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445172 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445172 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445172 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593445172 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445172 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445172 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445172 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539228 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539228 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539228 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539228 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539228 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539228 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593539228 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539228 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539228 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539228 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690906 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690906 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690906 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690906 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690906 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690906 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1131690906 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690906 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690906 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690906 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1459523811 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1459523811 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1459523811 SNP."
    },
    {
        "instruction": "In which chromosome is RS1459523811 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1459523811 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1459523811 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1459523811 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1459523811 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1459523811 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1459523811 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539366 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539366 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539366 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539366 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539366 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539366 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593539366 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539366 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539366 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539366 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS868434367 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS868434367 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS868434367 SNP."
    },
    {
        "instruction": "In which chromosome is RS868434367 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS868434367 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS868434367 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS868434367 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS868434367 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS868434367 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS868434367 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593434250 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434250 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434250 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434250 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434250 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434250 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593434250 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434250 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434250 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434250 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174063 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174063 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174063 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174063 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174063 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174063 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566174063 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174063 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174063 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174063 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593455667 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593455667 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593455667 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593455667 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593455667 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593455667 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593455667 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593455667 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593455667 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593455667 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS976503237 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS976503237 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS976503237 SNP."
    },
    {
        "instruction": "In which chromosome is RS976503237 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS976503237 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS976503237 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS976503237 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS976503237 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS976503237 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS976503237 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1048847950 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1048847950 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1048847950 SNP."
    },
    {
        "instruction": "In which chromosome is RS1048847950 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1048847950 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1048847950 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1048847950 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1048847950 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1048847950 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1048847950 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS750356534 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750356534 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750356534 SNP."
    },
    {
        "instruction": "In which chromosome is RS750356534 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750356534 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750356534 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750356534 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750356534 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750356534 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750356534 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS750850735 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750850735 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750850735 SNP."
    },
    {
        "instruction": "In which chromosome is RS750850735 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750850735 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750850735 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS750850735 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750850735 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750850735 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750850735 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593547664 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593547664 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593547664 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593547664 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593547664 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593547664 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593547664 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593547664 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593547664 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593547664 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566196389 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566196389 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566196389 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566196389 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566196389 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566196389 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1566196389 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566196389 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566196389 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566196389 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS770728170 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770728170 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770728170 SNP."
    },
    {
        "instruction": "In which chromosome is RS770728170 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770728170 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770728170 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS770728170 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770728170 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770728170 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770728170 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS770160524 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770160524 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770160524 SNP."
    },
    {
        "instruction": "In which chromosome is RS770160524 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770160524 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770160524 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS770160524 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770160524 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770160524 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770160524 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS747147942 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS747147942 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS747147942 SNP."
    },
    {
        "instruction": "In which chromosome is RS747147942 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS747147942 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS747147942 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS747147942 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS747147942 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS747147942 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS747147942 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS768929728 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS768929728 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS768929728 SNP."
    },
    {
        "instruction": "In which chromosome is RS768929728 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS768929728 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS768929728 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS768929728 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS768929728 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS768929728 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS768929728 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1017683562 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1017683562 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1017683562 SNP."
    },
    {
        "instruction": "In which chromosome is RS1017683562 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1017683562 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1017683562 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1017683562 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1017683562 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1017683562 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1017683562 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS755417160 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS755417160 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS755417160 SNP."
    },
    {
        "instruction": "In which chromosome is RS755417160 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS755417160 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS755417160 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS755417160 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS755417160 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS755417160 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS755417160 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS371805499 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371805499 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371805499 SNP."
    },
    {
        "instruction": "In which chromosome is RS371805499 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371805499 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371805499 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS371805499 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371805499 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371805499 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371805499 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS750581965 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750581965 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750581965 SNP."
    },
    {
        "instruction": "In which chromosome is RS750581965 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750581965 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750581965 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750581965 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750581965 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750581965 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750581965 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS377235036 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS377235036 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS377235036 SNP."
    },
    {
        "instruction": "In which chromosome is RS377235036 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS377235036 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS377235036 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS377235036 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS377235036 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS377235036 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS377235036 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593534733 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593534733 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593534733 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593534733 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593534733 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593534733 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593534733 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593534733 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593534733 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593534733 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS765386327 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS765386327 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS765386327 SNP."
    },
    {
        "instruction": "In which chromosome is RS765386327 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS765386327 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS765386327 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS765386327 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS765386327 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS765386327 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS765386327 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593453956 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593453956 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593453956 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593453956 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593453956 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593453956 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593453956 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593453956 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593453956 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593453956 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS566777900 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS566777900 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS566777900 SNP."
    },
    {
        "instruction": "In which chromosome is RS566777900 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS566777900 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS566777900 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS566777900 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS566777900 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS566777900 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS566777900 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS919345517 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS919345517 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS919345517 SNP."
    },
    {
        "instruction": "In which chromosome is RS919345517 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS919345517 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS919345517 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS919345517 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS919345517 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS919345517 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS919345517 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS746360576 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746360576 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746360576 SNP."
    },
    {
        "instruction": "In which chromosome is RS746360576 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746360576 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746360576 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS746360576 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS746360576 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746360576 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746360576 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS775560197 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775560197 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775560197 SNP."
    },
    {
        "instruction": "In which chromosome is RS775560197 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775560197 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775560197 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS775560197 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775560197 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775560197 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775560197 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1194487890 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1194487890 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1194487890 SNP."
    },
    {
        "instruction": "In which chromosome is RS1194487890 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1194487890 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1194487890 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1194487890 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1194487890 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1194487890 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1194487890 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS189574280 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS189574280 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS189574280 SNP."
    },
    {
        "instruction": "In which chromosome is RS189574280 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS189574280 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS189574280 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS189574280 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS189574280 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS189574280 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS189574280 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593529859 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593529859 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593529859 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593529859 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593529859 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593529859 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593529859 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593529859 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593529859 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593529859 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS751697681 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751697681 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751697681 SNP."
    },
    {
        "instruction": "In which chromosome is RS751697681 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751697681 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751697681 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS751697681 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751697681 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751697681 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751697681 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS398123331 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS398123331 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS398123331 SNP."
    },
    {
        "instruction": "In which chromosome is RS398123331 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS398123331 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS398123331 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS398123331 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS398123331 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS398123331 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS398123331 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1161993720 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1161993720 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1161993720 SNP."
    },
    {
        "instruction": "In which chromosome is RS1161993720 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1161993720 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1161993720 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1161993720 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1161993720 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1161993720 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1161993720 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539365 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539365 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539365 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539365 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539365 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539365 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593539365 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539365 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539365 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539365 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593449062 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593449062 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593449062 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593449062 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593449062 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593449062 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593449062 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593449062 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593449062 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593449062 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS768192190 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS768192190 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS768192190 SNP."
    },
    {
        "instruction": "In which chromosome is RS768192190 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS768192190 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS768192190 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS768192190 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS768192190 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS768192190 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS768192190 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS146236493 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS146236493 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS146236493 SNP."
    },
    {
        "instruction": "In which chromosome is RS146236493 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS146236493 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS146236493 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS146236493 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS146236493 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS146236493 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS146236493 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS766529534 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS766529534 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS766529534 SNP."
    },
    {
        "instruction": "In which chromosome is RS766529534 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS766529534 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS766529534 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS766529534 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS766529534 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS766529534 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS766529534 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593438023 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593438023 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593438023 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593438023 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593438023 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593438023 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593438023 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593438023 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593438023 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593438023 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS146897002 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS146897002 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS146897002 SNP."
    },
    {
        "instruction": "In which chromosome is RS146897002 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS146897002 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS146897002 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS146897002 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS146897002 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS146897002 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS146897002 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS564780653 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS564780653 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS564780653 SNP."
    },
    {
        "instruction": "In which chromosome is RS564780653 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS564780653 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS564780653 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS564780653 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS564780653 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS564780653 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS564780653 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS902298592 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS902298592 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS902298592 SNP."
    },
    {
        "instruction": "In which chromosome is RS902298592 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS902298592 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS902298592 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS902298592 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS902298592 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS902298592 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS902298592 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS149703672 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS149703672 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS149703672 SNP."
    },
    {
        "instruction": "In which chromosome is RS149703672 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS149703672 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS149703672 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS149703672 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS149703672 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS149703672 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS149703672 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1283644725 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1283644725 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1283644725 SNP."
    },
    {
        "instruction": "In which chromosome is RS1283644725 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1283644725 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1283644725 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1283644725 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1283644725 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1283644725 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1283644725 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952511865 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952511865 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952511865 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952511865 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952511865 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952511865 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952511865 SNP?",
        "output": "The variation length is 7 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952511865 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952511865 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952511865 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952088853 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952088853 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952088853 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952088853 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952088853 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952088853 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952088853 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952088853 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952088853 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952088853 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS775880919 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775880919 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775880919 SNP."
    },
    {
        "instruction": "In which chromosome is RS775880919 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775880919 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775880919 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS775880919 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775880919 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775880919 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775880919 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952832685 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952832685 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952832685 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952832685 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952832685 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952832685 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952832685 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952832685 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952832685 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952832685 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1349657979 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1349657979 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1349657979 SNP."
    },
    {
        "instruction": "In which chromosome is RS1349657979 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1349657979 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1349657979 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1349657979 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1349657979 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1349657979 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1349657979 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS776534331 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776534331 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776534331 SNP."
    },
    {
        "instruction": "In which chromosome is RS776534331 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776534331 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776534331 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS776534331 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776534331 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776534331 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776534331 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831606 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831606 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831606 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831606 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831606 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831606 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952831606 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831606 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831606 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831606 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS374157786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS374157786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS374157786 SNP."
    },
    {
        "instruction": "In which chromosome is RS374157786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS374157786 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS374157786 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS374157786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS374157786 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS374157786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS374157786 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949339014 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949339014 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949339014 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949339014 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949339014 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949339014 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949339014 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949339014 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949339014 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949339014 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS755704180 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS755704180 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS755704180 SNP."
    },
    {
        "instruction": "In which chromosome is RS755704180 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS755704180 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS755704180 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS755704180 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS755704180 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS755704180 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS755704180 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1949484299 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949484299 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949484299 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949484299 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949484299 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949484299 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949484299 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949484299 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949484299 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949484299 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948534275 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948534275 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948534275 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948534275 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948534275 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948534275 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948534275 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948534275 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948534275 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948534275 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952480749 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952480749 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952480749 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952480749 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952480749 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952480749 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952480749 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952480749 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952480749 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952480749 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS149359120 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS149359120 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS149359120 SNP."
    },
    {
        "instruction": "In which chromosome is RS149359120 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS149359120 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS149359120 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS149359120 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS149359120 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS149359120 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS149359120 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690895 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690895 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690895 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690895 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690895 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690895 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690895 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690895 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690895 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690895 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690877 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690877 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690877 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690877 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690877 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690877 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1131690877 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690877 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690877 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690877 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952089249 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952089249 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952089249 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952089249 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952089249 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952089249 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952089249 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952089249 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952089249 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952089249 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS974956317 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS974956317 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS974956317 SNP."
    },
    {
        "instruction": "In which chromosome is RS974956317 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS974956317 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS974956317 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS974956317 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS974956317 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS974956317 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS974956317 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949337837 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949337837 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949337837 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949337837 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949337837 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949337837 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949337837 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949337837 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949337837 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949337837 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1191072088 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1191072088 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1191072088 SNP."
    },
    {
        "instruction": "In which chromosome is RS1191072088 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1191072088 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1191072088 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1191072088 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1191072088 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1191072088 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1191072088 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948520103 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948520103 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948520103 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948520103 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948520103 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948520103 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948520103 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948520103 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948520103 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948520103 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778642 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778642 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778642 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778642 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778642 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778642 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778642 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778642 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778642 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778642 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS760787104 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS760787104 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS760787104 SNP."
    },
    {
        "instruction": "In which chromosome is RS760787104 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS760787104 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS760787104 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS760787104 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS760787104 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS760787104 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS760787104 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528716 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528716 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528716 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528716 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528716 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528716 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528716 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528716 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528716 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528716 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948513840 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948513840 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948513840 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948513840 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948513840 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948513840 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948513840 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948513840 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948513840 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948513840 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593456261 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593456261 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593456261 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593456261 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593456261 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593456261 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593456261 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593456261 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593456261 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593456261 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952054473 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952054473 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952054473 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952054473 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952054473 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952054473 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952054473 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952054473 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952054473 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952054473 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1455944671 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1455944671 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1455944671 SNP."
    },
    {
        "instruction": "In which chromosome is RS1455944671 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1455944671 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1455944671 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1455944671 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1455944671 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1455944671 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1455944671 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949507139 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949507139 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949507139 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949507139 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949507139 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949507139 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949507139 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949507139 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949507139 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949507139 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506524 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506524 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506524 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506524 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506524 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506524 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506524 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506524 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506524 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506524 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949432262 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949432262 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949432262 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949432262 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949432262 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949432262 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949432262 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949432262 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949432262 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949432262 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359922 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359922 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359922 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359922 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359922 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949359922 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949359922 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359922 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359922 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359922 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS908738769 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS908738769 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS908738769 SNP."
    },
    {
        "instruction": "In which chromosome is RS908738769 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS908738769 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS908738769 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS908738769 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS908738769 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS908738769 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS908738769 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1368593116 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1368593116 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1368593116 SNP."
    },
    {
        "instruction": "In which chromosome is RS1368593116 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1368593116 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1368593116 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1368593116 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1368593116 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1368593116 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1368593116 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952455310 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952455310 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952455310 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952455310 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952455310 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952455310 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952455310 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952455310 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952455310 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952455310 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948513922 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948513922 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948513922 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948513922 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948513922 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948513922 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948513922 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948513922 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948513922 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948513922 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948522903 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948522903 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948522903 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948522903 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948522903 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948522903 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948522903 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948522903 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948522903 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948522903 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948533963 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948533963 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948533963 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948533963 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948533963 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948533963 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948533963 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948533963 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948533963 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948533963 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528826 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528826 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528826 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528826 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528826 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528826 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528826 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528826 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528826 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528826 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS375645171 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS375645171 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS375645171 SNP."
    },
    {
        "instruction": "In which chromosome is RS375645171 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS375645171 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS375645171 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS375645171 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS375645171 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS375645171 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS375645171 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948514269 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948514269 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948514269 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948514269 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948514269 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948514269 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948514269 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948514269 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948514269 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948514269 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952480132 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952480132 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952480132 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952480132 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952480132 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952480132 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952480132 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952480132 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952480132 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952480132 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1402321066 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1402321066 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1402321066 SNP."
    },
    {
        "instruction": "In which chromosome is RS1402321066 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1402321066 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1402321066 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1402321066 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1402321066 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1402321066 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1402321066 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1343212063 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1343212063 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1343212063 SNP."
    },
    {
        "instruction": "In which chromosome is RS1343212063 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1343212063 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1343212063 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1343212063 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1343212063 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1343212063 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1343212063 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS147085238 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS147085238 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS147085238 SNP."
    },
    {
        "instruction": "In which chromosome is RS147085238 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS147085238 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS147085238 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS147085238 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS147085238 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS147085238 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS147085238 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1371181708 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1371181708 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1371181708 SNP."
    },
    {
        "instruction": "In which chromosome is RS1371181708 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1371181708 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1371181708 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1371181708 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1371181708 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1371181708 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1371181708 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1312883856 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1312883856 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1312883856 SNP."
    },
    {
        "instruction": "In which chromosome is RS1312883856 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1312883856 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1312883856 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1312883856 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1312883856 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1312883856 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1312883856 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1429553692 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1429553692 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1429553692 SNP."
    },
    {
        "instruction": "In which chromosome is RS1429553692 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1429553692 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1429553692 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1429553692 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1429553692 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1429553692 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1429553692 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS764881599 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS764881599 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS764881599 SNP."
    },
    {
        "instruction": "In which chromosome is RS764881599 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS764881599 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS764881599 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS764881599 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS764881599 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS764881599 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS764881599 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625561 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625561 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625561 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625561 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625561 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625561 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625561 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625561 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625561 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625561 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831740 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831740 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831740 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831740 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831740 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831740 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952831740 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831740 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831740 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831740 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952624919 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952624919 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952624919 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952624919 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952624919 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952624919 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952624919 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952624919 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952624919 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952624919 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1273219762 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1273219762 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1273219762 SNP."
    },
    {
        "instruction": "In which chromosome is RS1273219762 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1273219762 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1273219762 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1273219762 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1273219762 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1273219762 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1273219762 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1342634687 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1342634687 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1342634687 SNP."
    },
    {
        "instruction": "In which chromosome is RS1342634687 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1342634687 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1342634687 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1342634687 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1342634687 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1342634687 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1342634687 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1199831823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1199831823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1199831823 SNP."
    },
    {
        "instruction": "In which chromosome is RS1199831823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1199831823 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1199831823 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1199831823 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1199831823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1199831823 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1199831823 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS934931283 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS934931283 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS934931283 SNP."
    },
    {
        "instruction": "In which chromosome is RS934931283 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS934931283 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS934931283 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS934931283 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS934931283 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS934931283 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS934931283 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566235448 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566235448 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566235448 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566235448 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566235448 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566235448 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566235448 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566235448 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566235448 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566235448 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1593414365 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593414365 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593414365 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593414365 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593414365 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593414365 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593414365 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593414365 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593414365 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593414365 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433358 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433358 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433358 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433358 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433358 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433358 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949433358 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433358 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433358 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433358 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952726441 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952726441 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952726441 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952726441 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952726441 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952726441 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952726441 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952726441 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952726441 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952726441 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS150600740 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS150600740 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS150600740 SNP."
    },
    {
        "instruction": "In which chromosome is RS150600740 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS150600740 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS150600740 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS150600740 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS150600740 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS150600740 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS150600740 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948514334 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948514334 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948514334 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948514334 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948514334 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948514334 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948514334 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948514334 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948514334 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948514334 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528678 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528678 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528678 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528678 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528678 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528678 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528678 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528678 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528678 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528678 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948533760 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948533760 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948533760 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948533760 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948533760 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948533760 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948533760 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948533760 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948533760 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948533760 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS898303682 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS898303682 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS898303682 SNP."
    },
    {
        "instruction": "In which chromosome is RS898303682 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS898303682 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS898303682 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS898303682 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS898303682 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS898303682 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS898303682 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528654 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528654 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528654 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528654 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528654 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528654 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528654 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528654 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528654 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528654 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1433767914 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1433767914 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1433767914 SNP."
    },
    {
        "instruction": "In which chromosome is RS1433767914 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1433767914 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1433767914 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1433767914 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1433767914 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1433767914 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1433767914 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS779045727 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS779045727 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS779045727 SNP."
    },
    {
        "instruction": "In which chromosome is RS779045727 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS779045727 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS779045727 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS779045727 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS779045727 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS779045727 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS779045727 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1251503080 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1251503080 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1251503080 SNP."
    },
    {
        "instruction": "In which chromosome is RS1251503080 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1251503080 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1251503080 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1251503080 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1251503080 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1251503080 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1251503080 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS900955797 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS900955797 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS900955797 SNP."
    },
    {
        "instruction": "In which chromosome is RS900955797 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS900955797 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS900955797 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS900955797 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS900955797 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS900955797 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS900955797 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690848 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690848 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690848 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690848 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690848 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690848 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690848 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690848 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690848 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690848 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092895 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092895 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092895 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092895 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092895 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092895 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS3092895 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092895 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092895 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092895 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1421476380 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1421476380 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1421476380 SNP."
    },
    {
        "instruction": "In which chromosome is RS1421476380 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1421476380 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1421476380 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1421476380 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1421476380 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1421476380 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1421476380 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060504825 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060504825 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060504825 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060504825 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060504825 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060504825 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1060504825 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060504825 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060504825 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060504825 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625561 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625561 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625561 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625561 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625561 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625561 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625561 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625561 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625561 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625561 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690858 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690858 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690858 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690858 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690858 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690858 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690858 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690858 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690858 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690858 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949360394 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949360394 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949360394 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949360394 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949360394 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949360394 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949360394 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949360394 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949360394 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949360394 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS184754468 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS184754468 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS184754468 SNP."
    },
    {
        "instruction": "In which chromosome is RS184754468 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS184754468 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS184754468 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS184754468 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS184754468 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS184754468 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS184754468 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952832267 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952832267 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952832267 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952832267 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952832267 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952832267 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952832267 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952832267 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952832267 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952832267 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952655473 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952655473 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952655473 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952655473 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952655473 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952655473 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952655473 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952655473 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952655473 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952655473 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952089186 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952089186 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952089186 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952089186 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952089186 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952089186 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952089186 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952089186 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952089186 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952089186 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS554834063 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS554834063 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS554834063 SNP."
    },
    {
        "instruction": "In which chromosome is RS554834063 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS554834063 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS554834063 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS554834063 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS554834063 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS554834063 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS554834063 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593529910 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593529910 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593529910 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593529910 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593529910 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593529910 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593529910 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593529910 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593529910 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593529910 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1326990660 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1326990660 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1326990660 SNP."
    },
    {
        "instruction": "In which chromosome is RS1326990660 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1326990660 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1326990660 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1326990660 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1326990660 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1326990660 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1326990660 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952830946 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952830946 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952830946 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952830946 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952830946 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952830946 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952830946 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952830946 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952830946 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952830946 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949384058 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384058 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384058 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384058 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384058 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949384058 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949384058 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384058 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384058 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384058 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS564059250 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS564059250 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS564059250 SNP."
    },
    {
        "instruction": "In which chromosome is RS564059250 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS564059250 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS564059250 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS564059250 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS564059250 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS564059250 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS564059250 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1286489738 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1286489738 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1286489738 SNP."
    },
    {
        "instruction": "In which chromosome is RS1286489738 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1286489738 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1286489738 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1286489738 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1286489738 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1286489738 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1286489738 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS761015353 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761015353 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761015353 SNP."
    },
    {
        "instruction": "In which chromosome is RS761015353 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761015353 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761015353 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS761015353 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761015353 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761015353 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761015353 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS138201027 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS138201027 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS138201027 SNP."
    },
    {
        "instruction": "In which chromosome is RS138201027 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS138201027 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS138201027 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS138201027 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS138201027 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS138201027 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS138201027 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948534757 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948534757 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948534757 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948534757 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948534757 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948534757 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948534757 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948534757 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948534757 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948534757 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949419727 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949419727 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949419727 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949419727 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949419727 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949419727 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949419727 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949419727 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949419727 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949419727 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359821 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359821 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359821 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359821 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359821 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949359821 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949359821 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359821 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359821 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359821 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS200501806 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200501806 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200501806 SNP."
    },
    {
        "instruction": "In which chromosome is RS200501806 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200501806 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200501806 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS200501806 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200501806 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200501806 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200501806 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949384169 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384169 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384169 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384169 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384169 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949384169 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949384169 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384169 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384169 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384169 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS201458896 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201458896 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201458896 SNP."
    },
    {
        "instruction": "In which chromosome is RS201458896 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201458896 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201458896 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS201458896 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201458896 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201458896 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201458896 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS777789154 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS777789154 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS777789154 SNP."
    },
    {
        "instruction": "In which chromosome is RS777789154 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS777789154 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS777789154 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS777789154 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS777789154 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS777789154 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS777789154 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952726482 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952726482 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952726482 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952726482 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952726482 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952726482 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952726482 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952726482 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952726482 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952726482 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952051704 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952051704 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952051704 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952051704 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952051704 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952051704 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1952051704 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952051704 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952051704 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952051704 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952655426 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952655426 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952655426 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952655426 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952655426 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952655426 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952655426 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952655426 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952655426 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952655426 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952089852 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952089852 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952089852 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952089852 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952089852 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952089852 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952089852 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952089852 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952089852 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952089852 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1328603105 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1328603105 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1328603105 SNP."
    },
    {
        "instruction": "In which chromosome is RS1328603105 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1328603105 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1328603105 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1328603105 SNP?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for RS1328603105 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1328603105 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1328603105 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1401332173 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1401332173 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1401332173 SNP."
    },
    {
        "instruction": "In which chromosome is RS1401332173 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1401332173 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1401332173 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1401332173 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1401332173 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1401332173 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1401332173 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433617 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433617 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433617 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433617 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433617 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433617 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949433617 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433617 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433617 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433617 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433250 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433250 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433250 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433250 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433250 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433250 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949433250 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433250 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433250 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433250 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS869264218 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS869264218 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS869264218 SNP."
    },
    {
        "instruction": "In which chromosome is RS869264218 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS869264218 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS869264218 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS869264218 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS869264218 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS869264218 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS869264218 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506548 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506548 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506548 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506548 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506548 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506548 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949506548 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506548 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506548 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506548 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS4151539 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151539 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151539 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151539 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151539 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151539 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS4151539 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151539 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151539 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151539 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS529366765 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS529366765 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS529366765 SNP."
    },
    {
        "instruction": "In which chromosome is RS529366765 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS529366765 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS529366765 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS529366765 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS529366765 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS529366765 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS529366765 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359779 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359779 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359779 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359779 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359779 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949359779 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949359779 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359779 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359779 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359779 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS900955797 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS900955797 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS900955797 SNP."
    },
    {
        "instruction": "In which chromosome is RS900955797 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS900955797 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS900955797 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS900955797 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS900955797 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS900955797 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS900955797 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625382 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625382 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625382 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625382 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625382 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625382 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625382 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625382 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625382 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625382 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1349657979 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1349657979 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1349657979 SNP."
    },
    {
        "instruction": "In which chromosome is RS1349657979 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1349657979 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1349657979 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1349657979 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1349657979 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1349657979 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1349657979 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949484627 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949484627 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949484627 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949484627 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949484627 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949484627 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949484627 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949484627 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949484627 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949484627 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433985 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433985 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433985 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433985 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433985 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433985 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949433985 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433985 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433985 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433985 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949338800 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949338800 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949338800 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949338800 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949338800 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949338800 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949338800 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949338800 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949338800 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949338800 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948533141 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948533141 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948533141 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948533141 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948533141 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948533141 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948533141 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948533141 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948533141 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948533141 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949507415 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949507415 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949507415 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949507415 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949507415 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949507415 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949507415 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949507415 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949507415 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949507415 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952655166 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952655166 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952655166 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952655166 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952655166 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952655166 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952655166 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952655166 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952655166 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952655166 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625286 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625286 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625286 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625286 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625286 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625286 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625286 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625286 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625286 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625286 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952523027 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952523027 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952523027 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952523027 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952523027 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952523027 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952523027 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952523027 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952523027 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952523027 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240957 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240957 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240957 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240957 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240957 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240957 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566240957 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240957 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240957 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240957 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952511922 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952511922 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952511922 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952511922 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952511922 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952511922 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1952511922 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952511922 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952511922 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952511922 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948519905 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948519905 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948519905 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948519905 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948519905 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948519905 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948519905 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948519905 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948519905 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948519905 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1034616967 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1034616967 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1034616967 SNP."
    },
    {
        "instruction": "In which chromosome is RS1034616967 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1034616967 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1034616967 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1034616967 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1034616967 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1034616967 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1034616967 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952511717 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952511717 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952511717 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952511717 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952511717 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952511717 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952511717 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952511717 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952511717 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952511717 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948519774 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948519774 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948519774 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948519774 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948519774 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948519774 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948519774 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948519774 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948519774 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948519774 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1313614748 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1313614748 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1313614748 SNP."
    },
    {
        "instruction": "In which chromosome is RS1313614748 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1313614748 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1313614748 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1313614748 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1313614748 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1313614748 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1313614748 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS775381228 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775381228 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775381228 SNP."
    },
    {
        "instruction": "In which chromosome is RS775381228 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775381228 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775381228 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS775381228 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775381228 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775381228 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775381228 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949338354 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949338354 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949338354 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949338354 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949338354 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949338354 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949338354 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949338354 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949338354 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949338354 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727399 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727399 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727399 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727399 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727399 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727399 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727399 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727399 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727399 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727399 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952090786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952090786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952090786 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952090786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952090786 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952090786 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952090786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952090786 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952090786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952090786 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690906 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690906 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690906 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690906 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690906 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690906 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690906 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690906 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690906 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690906 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS1328198608 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1328198608 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1328198608 SNP."
    },
    {
        "instruction": "In which chromosome is RS1328198608 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1328198608 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1328198608 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1328198608 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1328198608 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1328198608 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1328198608 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952511945 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952511945 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952511945 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952511945 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952511945 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952511945 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952511945 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952511945 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952511945 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952511945 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831003 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831003 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831003 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831003 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831003 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831003 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952831003 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831003 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831003 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831003 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1289148853 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1289148853 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1289148853 SNP."
    },
    {
        "instruction": "In which chromosome is RS1289148853 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1289148853 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1289148853 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1289148853 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1289148853 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1289148853 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1289148853 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948522676 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948522676 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948522676 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948522676 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948522676 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948522676 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948522676 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948522676 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948522676 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948522676 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949484337 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949484337 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949484337 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949484337 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949484337 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949484337 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949484337 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949484337 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949484337 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949484337 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727463 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727463 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727463 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727463 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727463 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727463 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727463 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727463 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727463 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727463 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555279228 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555279228 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555279228 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555279228 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555279228 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555279228 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555279228 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555279228 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555279228 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555279228 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690843 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690843 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690843 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690843 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690843 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690843 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690843 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690843 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690843 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690843 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS148501460 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS148501460 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS148501460 SNP."
    },
    {
        "instruction": "In which chromosome is RS148501460 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS148501460 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS148501460 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS148501460 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS148501460 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS148501460 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS148501460 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949430414 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949430414 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949430414 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949430414 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949430414 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949430414 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949430414 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949430414 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949430414 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949430414 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS767908749 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS767908749 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS767908749 SNP."
    },
    {
        "instruction": "In which chromosome is RS767908749 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS767908749 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS767908749 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS767908749 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS767908749 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS767908749 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS767908749 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948514475 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948514475 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948514475 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948514475 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948514475 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948514475 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948514475 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948514475 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948514475 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948514475 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506548 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506548 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506548 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506548 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506548 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506548 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506548 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506548 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506548 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506548 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949360348 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949360348 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949360348 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949360348 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949360348 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949360348 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949360348 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949360348 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949360348 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949360348 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS747509282 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS747509282 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS747509282 SNP."
    },
    {
        "instruction": "In which chromosome is RS747509282 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS747509282 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS747509282 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS747509282 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS747509282 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS747509282 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS747509282 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS866664638 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS866664638 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS866664638 SNP."
    },
    {
        "instruction": "In which chromosome is RS866664638 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS866664638 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS866664638 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS866664638 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS866664638 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS866664638 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS866664638 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1210328667 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1210328667 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1210328667 SNP."
    },
    {
        "instruction": "In which chromosome is RS1210328667 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1210328667 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1210328667 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1210328667 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1210328667 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1210328667 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1210328667 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286573 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286573 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286573 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286573 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286573 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286573 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286573 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286573 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286573 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286573 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952680701 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952680701 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952680701 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952680701 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952680701 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952680701 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952680701 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952680701 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952680701 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952680701 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952456105 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952456105 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952456105 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952456105 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952456105 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952456105 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952456105 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952456105 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952456105 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952456105 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS749739772 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS749739772 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS749739772 SNP."
    },
    {
        "instruction": "In which chromosome is RS749739772 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS749739772 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS749739772 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS749739772 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS749739772 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS749739772 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS749739772 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS143948310 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS143948310 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS143948310 SNP."
    },
    {
        "instruction": "In which chromosome is RS143948310 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS143948310 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS143948310 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS143948310 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS143948310 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS143948310 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS143948310 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359489 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359489 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359489 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359489 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359489 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949359489 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949359489 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359489 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359489 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359489 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949505926 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949505926 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949505926 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949505926 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949505926 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949505926 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949505926 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949505926 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949505926 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949505926 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS769113950 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769113950 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769113950 SNP."
    },
    {
        "instruction": "In which chromosome is RS769113950 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769113950 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769113950 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS769113950 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769113950 SNP?",
        "output": "The origin is paternal."
    },
    {
        "instruction": "What is the type of genetic variation for RS769113950 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769113950 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS774196937 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS774196937 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS774196937 SNP."
    },
    {
        "instruction": "In which chromosome is RS774196937 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS774196937 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS774196937 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS774196937 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS774196937 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS774196937 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS774196937 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952832267 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952832267 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952832267 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952832267 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952832267 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952832267 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952832267 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952832267 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952832267 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952832267 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1371240619 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1371240619 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1371240619 SNP."
    },
    {
        "instruction": "In which chromosome is RS1371240619 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1371240619 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1371240619 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1371240619 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1371240619 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1371240619 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1371240619 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412272 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412272 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412272 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412272 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412272 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412272 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412272 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412272 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412272 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412272 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS572454921 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS572454921 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS572454921 SNP."
    },
    {
        "instruction": "In which chromosome is RS572454921 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS572454921 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS572454921 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS572454921 SNP?",
        "output": "The variation length is 9 base pairs."
    },
    {
        "instruction": "What is the origin for RS572454921 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS572454921 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS572454921 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS1952523113 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952523113 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952523113 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952523113 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952523113 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952523113 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952523113 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952523113 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952523113 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952523113 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566192505 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566192505 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566192505 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566192505 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566192505 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566192505 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566192505 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566192505 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566192505 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566192505 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949359622 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949359622 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949359622 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949359622 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949359622 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949359622 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949359622 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949359622 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949359622 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949359622 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS757198343 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS757198343 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS757198343 SNP."
    },
    {
        "instruction": "In which chromosome is RS757198343 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS757198343 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS757198343 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS757198343 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS757198343 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS757198343 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS757198343 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1160394123 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1160394123 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1160394123 SNP."
    },
    {
        "instruction": "In which chromosome is RS1160394123 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1160394123 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1160394123 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1160394123 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1160394123 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1160394123 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1160394123 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS749495284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS749495284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS749495284 SNP."
    },
    {
        "instruction": "In which chromosome is RS749495284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS749495284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS749495284 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS749495284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS749495284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS749495284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS749495284 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS947540268 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS947540268 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS947540268 SNP."
    },
    {
        "instruction": "In which chromosome is RS947540268 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS947540268 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS947540268 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS947540268 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS947540268 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS947540268 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS947540268 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949358874 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949358874 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949358874 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949358874 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949358874 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949358874 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949358874 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949358874 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949358874 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949358874 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433558 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433558 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433558 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433558 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433558 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433558 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949433558 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433558 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433558 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433558 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948522862 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948522862 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948522862 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948522862 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948522862 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948522862 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948522862 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948522862 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948522862 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948522862 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593434342 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434342 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434342 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434342 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434342 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434342 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593434342 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434342 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434342 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434342 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS374157786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS374157786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS374157786 SNP."
    },
    {
        "instruction": "In which chromosome is RS374157786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS374157786 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS374157786 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS374157786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS374157786 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS374157786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS374157786 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566237785 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566237785 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566237785 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566237785 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566237785 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566237785 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566237785 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566237785 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566237785 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566237785 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1429451823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1429451823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1429451823 SNP."
    },
    {
        "instruction": "In which chromosome is RS1429451823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1429451823 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1429451823 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1429451823 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1429451823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1429451823 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1429451823 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS376408183 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS376408183 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS376408183 SNP."
    },
    {
        "instruction": "In which chromosome is RS376408183 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS376408183 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS376408183 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS376408183 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS376408183 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS376408183 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS376408183 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS770277291 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770277291 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770277291 SNP."
    },
    {
        "instruction": "In which chromosome is RS770277291 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770277291 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770277291 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS770277291 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770277291 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770277291 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770277291 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831579 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831579 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831579 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831579 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831579 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831579 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952831579 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831579 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831579 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831579 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1201977804 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1201977804 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1201977804 SNP."
    },
    {
        "instruction": "In which chromosome is RS1201977804 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1201977804 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1201977804 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1201977804 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1201977804 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1201977804 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1201977804 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS778503152 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS778503152 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS778503152 SNP."
    },
    {
        "instruction": "In which chromosome is RS778503152 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS778503152 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS778503152 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS778503152 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS778503152 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS778503152 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS778503152 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952716275 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952716275 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952716275 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952716275 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952716275 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952716275 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952716275 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952716275 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952716275 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952716275 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS769618862 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769618862 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769618862 SNP."
    },
    {
        "instruction": "In which chromosome is RS769618862 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769618862 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769618862 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS769618862 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769618862 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS769618862 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769618862 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506601 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506601 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506601 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506601 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506601 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506601 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506601 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506601 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506601 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506601 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS775161380 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775161380 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775161380 SNP."
    },
    {
        "instruction": "In which chromosome is RS775161380 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775161380 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775161380 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS775161380 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775161380 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775161380 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775161380 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727580 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727580 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727580 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727580 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727580 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727580 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727580 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727580 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727580 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727580 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433927 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433927 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433927 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433927 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433927 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433927 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949433927 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433927 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433927 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433927 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948523129 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948523129 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948523129 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948523129 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948523129 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948523129 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948523129 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948523129 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948523129 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948523129 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952657220 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952657220 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952657220 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952657220 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952657220 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952657220 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952657220 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952657220 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952657220 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952657220 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528429 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528429 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528429 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528429 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528429 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528429 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528429 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528429 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528429 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528429 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952680086 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952680086 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952680086 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952680086 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952680086 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952680086 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952680086 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952680086 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952680086 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952680086 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS761999108 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761999108 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761999108 SNP."
    },
    {
        "instruction": "In which chromosome is RS761999108 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761999108 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761999108 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS761999108 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761999108 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761999108 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761999108 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506762 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506762 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506762 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506762 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506762 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506762 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506762 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506762 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506762 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506762 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1375214454 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1375214454 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1375214454 SNP."
    },
    {
        "instruction": "In which chromosome is RS1375214454 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1375214454 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1375214454 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1375214454 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS1375214454 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1375214454 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1375214454 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS750946437 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750946437 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750946437 SNP."
    },
    {
        "instruction": "In which chromosome is RS750946437 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750946437 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750946437 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS750946437 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750946437 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750946437 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750946437 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1015497370 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1015497370 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1015497370 SNP."
    },
    {
        "instruction": "In which chromosome is RS1015497370 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1015497370 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1015497370 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1015497370 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1015497370 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1015497370 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1015497370 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952051803 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952051803 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952051803 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952051803 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952051803 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952051803 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952051803 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952051803 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952051803 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952051803 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949528633 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949528633 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949528633 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949528633 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949528633 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949528633 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949528633 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949528633 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949528633 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949528633 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952090208 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952090208 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952090208 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952090208 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952090208 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952090208 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952090208 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952090208 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952090208 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952090208 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625902 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625902 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625902 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625902 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625902 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625902 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625902 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625902 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625902 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625902 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853293 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853293 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853293 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853293 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853293 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS137853293 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS137853293 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853293 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853293 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853293 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949337837 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949337837 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949337837 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949337837 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949337837 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949337837 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949337837 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949337837 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949337837 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949337837 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949384321 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384321 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384321 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384321 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384321 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949384321 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949384321 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384321 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384321 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384321 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1422900655 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1422900655 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1422900655 SNP."
    },
    {
        "instruction": "In which chromosome is RS1422900655 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1422900655 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1422900655 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1422900655 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1422900655 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1422900655 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1422900655 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949433950 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949433950 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949433950 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949433950 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949433950 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949433950 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949433950 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949433950 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949433950 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949433950 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948533324 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948533324 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948533324 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948533324 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948533324 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948533324 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948533324 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948533324 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948533324 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948533324 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727557 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727557 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727557 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727557 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727557 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727557 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727557 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727557 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727557 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727557 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949384761 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384761 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384761 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384761 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384761 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949384761 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949384761 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384761 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384761 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384761 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690911 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690911 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690911 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690911 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690911 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690911 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1131690911 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690911 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690911 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690911 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS748923368 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS748923368 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS748923368 SNP."
    },
    {
        "instruction": "In which chromosome is RS748923368 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS748923368 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS748923368 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS748923368 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS748923368 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS748923368 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS748923368 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952481513 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952481513 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952481513 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952481513 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952481513 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952481513 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952481513 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952481513 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952481513 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952481513 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1161993720 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1161993720 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1161993720 SNP."
    },
    {
        "instruction": "In which chromosome is RS1161993720 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1161993720 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1161993720 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1161993720 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1161993720 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1161993720 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1161993720 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727608 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727608 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727608 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727608 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727608 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727608 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727608 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727608 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727608 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727608 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948534262 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948534262 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948534262 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948534262 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948534262 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948534262 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948534262 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948534262 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948534262 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948534262 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1032510984 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1032510984 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1032510984 SNP."
    },
    {
        "instruction": "In which chromosome is RS1032510984 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1032510984 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1032510984 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1032510984 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1032510984 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1032510984 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1032510984 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1301539544 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1301539544 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1301539544 SNP."
    },
    {
        "instruction": "In which chromosome is RS1301539544 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1301539544 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1301539544 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1301539544 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1301539544 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1301539544 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1301539544 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952655034 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952655034 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952655034 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952655034 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952655034 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952655034 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952655034 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952655034 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952655034 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952655034 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1161450606 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1161450606 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1161450606 SNP."
    },
    {
        "instruction": "In which chromosome is RS1161450606 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1161450606 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1161450606 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1161450606 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1161450606 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1161450606 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1161450606 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948534047 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948534047 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948534047 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948534047 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948534047 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948534047 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948534047 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948534047 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948534047 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948534047 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952655335 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952655335 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952655335 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952655335 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952655335 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952655335 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952655335 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952655335 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952655335 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952655335 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1285455572 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1285455572 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1285455572 SNP."
    },
    {
        "instruction": "In which chromosome is RS1285455572 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1285455572 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1285455572 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1285455572 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1285455572 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1285455572 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1285455572 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS768305224 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS768305224 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS768305224 SNP."
    },
    {
        "instruction": "In which chromosome is RS768305224 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS768305224 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS768305224 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS768305224 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS768305224 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS768305224 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS768305224 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952625956 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952625956 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952625956 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952625956 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952625956 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952625956 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952625956 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952625956 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952625956 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952625956 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952626193 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952626193 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952626193 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952626193 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952626193 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952626193 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952626193 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952626193 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952626193 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952626193 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS780588550 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780588550 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780588550 SNP."
    },
    {
        "instruction": "In which chromosome is RS780588550 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780588550 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780588550 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS780588550 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS780588550 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780588550 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780588550 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS761068783 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761068783 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761068783 SNP."
    },
    {
        "instruction": "In which chromosome is RS761068783 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761068783 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761068783 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS761068783 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761068783 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761068783 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761068783 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1243796201 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1243796201 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1243796201 SNP."
    },
    {
        "instruction": "In which chromosome is RS1243796201 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1243796201 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1243796201 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1243796201 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1243796201 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1243796201 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1243796201 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1057505320 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1057505320 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1057505320 SNP."
    },
    {
        "instruction": "In which chromosome is RS1057505320 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1057505320 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1057505320 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1057505320 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1057505320 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1057505320 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1057505320 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS777670056 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS777670056 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS777670056 SNP."
    },
    {
        "instruction": "In which chromosome is RS777670056 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS777670056 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS777670056 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS777670056 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS777670056 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS777670056 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS777670056 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS776591592 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776591592 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776591592 SNP."
    },
    {
        "instruction": "In which chromosome is RS776591592 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776591592 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776591592 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS776591592 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776591592 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776591592 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776591592 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1034616967 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1034616967 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1034616967 SNP."
    },
    {
        "instruction": "In which chromosome is RS1034616967 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1034616967 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1034616967 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1034616967 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1034616967 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1034616967 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1034616967 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593434246 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434246 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434246 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434246 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434246 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434246 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593434246 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434246 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434246 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434246 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS781708508 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS781708508 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS781708508 SNP."
    },
    {
        "instruction": "In which chromosome is RS781708508 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS781708508 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS781708508 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS781708508 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS781708508 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS781708508 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS781708508 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS762613976 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762613976 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762613976 SNP."
    },
    {
        "instruction": "In which chromosome is RS762613976 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762613976 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762613976 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS762613976 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762613976 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762613976 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762613976 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949384188 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949384188 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949384188 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949384188 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949384188 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949384188 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949384188 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949384188 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949384188 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949384188 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952089775 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952089775 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952089775 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952089775 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952089775 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952089775 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952089775 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952089775 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952089775 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952089775 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1470516350 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1470516350 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1470516350 SNP."
    },
    {
        "instruction": "In which chromosome is RS1470516350 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1470516350 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1470516350 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1470516350 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1470516350 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1470516350 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1470516350 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048337?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048337. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048337."
    },
    {
        "instruction": "In which chromosome is SNV1048337 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048337?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048337, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048337?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048337?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048337?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048337?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048340?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048340. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048340."
    },
    {
        "instruction": "In which chromosome is SNV1048340 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048340?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048340, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048340?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048340?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048340?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048340?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048356?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048356. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048356."
    },
    {
        "instruction": "In which chromosome is SNV1048356 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048356?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048356, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048356?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048356?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048356?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048356?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048341?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048341. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048341."
    },
    {
        "instruction": "In which chromosome is SNV1048341 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048341?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048341, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048341?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048341?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048341?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048341?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048348?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048348. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048348."
    },
    {
        "instruction": "In which chromosome is SNV1048348 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048348?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048348, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048348?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048348?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048348?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048348?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048354?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048354. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048354."
    },
    {
        "instruction": "In which chromosome is SNV1048354 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048354?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048354, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048354?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048354?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048354?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048354?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048338?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048338. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048338."
    },
    {
        "instruction": "In which chromosome is SNV1048338 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048338?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048338, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048338?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048338?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048338?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048338?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048353?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048353. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048353."
    },
    {
        "instruction": "In which chromosome is SNV1048353 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048353?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048353, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048353?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048353?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048353?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048353?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048359?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048359. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048359."
    },
    {
        "instruction": "In which chromosome is SNV1048359 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048359?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048359, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048359?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048359?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048359?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048359?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048344?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048344. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048344."
    },
    {
        "instruction": "In which chromosome is SNV1048344 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048344?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048344, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048344?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048344?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048344?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048344?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048339?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048339. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048339."
    },
    {
        "instruction": "In which chromosome is SNV1048339 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048339?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048339, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048339?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048339?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048339?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048339?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048358?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048358. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048358."
    },
    {
        "instruction": "In which chromosome is SNV1048358 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048358?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048358, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048358?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048358?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048358?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048358?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048349?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048349. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048349."
    },
    {
        "instruction": "In which chromosome is SNV1048349 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048349?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048349, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048349?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048349?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048349?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048349?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048351?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048351. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048351."
    },
    {
        "instruction": "In which chromosome is SNV1048351 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048351?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048351, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048351?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048351?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048351?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048351?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048342?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048342. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048342."
    },
    {
        "instruction": "In which chromosome is SNV1048342 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048342?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048342, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048342?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048342?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048342?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048342?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048361?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048361. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048361."
    },
    {
        "instruction": "In which chromosome is SNV1048361 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048361?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048361, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048361?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048361?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048361?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048361?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048347?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048347. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048347."
    },
    {
        "instruction": "In which chromosome is SNV1048347 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048347?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048347, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048347?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048347?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048347?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048347?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048355?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048355. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048355."
    },
    {
        "instruction": "In which chromosome is SNV1048355 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048355?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048355, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048355?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048355?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048355?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048355?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048346?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048346. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048346."
    },
    {
        "instruction": "In which chromosome is SNV1048346 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048346?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048346, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048346?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048346?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048346?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048346?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048345?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048345. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048345."
    },
    {
        "instruction": "In which chromosome is SNV1048345 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048345?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048345, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048345?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048345?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048345?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048345?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048352?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048352. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048352."
    },
    {
        "instruction": "In which chromosome is SNV1048352 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048352?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048352, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1048352?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048352?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048352?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048352?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048336?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048336. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048336."
    },
    {
        "instruction": "In which chromosome is SNV1048336 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048336?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048336, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048336?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048336?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048336?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048336?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1056156?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1056156. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1056156."
    },
    {
        "instruction": "In which chromosome is SNV1056156 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1056156?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1056156, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1056156?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1056156?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1056156?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1056156?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1056157?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1056157. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1056157."
    },
    {
        "instruction": "In which chromosome is SNV1056157 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1056157?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1056157, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1056157?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1056157?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1056157?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1056157?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 1062999?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1062999. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1062999."
    },
    {
        "instruction": "In which chromosome is 1062999 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1062999?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1062999, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 1062999?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for 1062999?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1062999?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1062999?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1062991?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1062991. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1062991."
    },
    {
        "instruction": "In which chromosome is DUP1062991 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1062991?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1062991, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1062991?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1062991?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1062991?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1062991?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062992?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062992. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062992."
    },
    {
        "instruction": "In which chromosome is SNV1062992 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062992?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062992, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062992?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062992?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062992?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062992?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1063004?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063004. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063004."
    },
    {
        "instruction": "In which chromosome is SNV1063004 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063004?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063004, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063004?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063004?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063004?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063004?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DUP1062996?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1062996. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1062996."
    },
    {
        "instruction": "In which chromosome is DUP1062996 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1062996?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1062996, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1062996?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1062996?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1062996?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1062996?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062998?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062998. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062998."
    },
    {
        "instruction": "In which chromosome is SNV1062998 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062998?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062998, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062998?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062998?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062998?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062998?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1062994?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062994. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062994."
    },
    {
        "instruction": "In which chromosome is SNV1062994 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062994?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062994, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062994?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062994?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062994?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062994?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690881 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690881 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690881 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690881 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690881 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690881 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690881 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690881 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690881 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690881 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1063008?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063008. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063008."
    },
    {
        "instruction": "In which chromosome is SNV1063008 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063008?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063008, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063008?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063008?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063008?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063008?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1063009?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063009. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063009."
    },
    {
        "instruction": "In which chromosome is SNV1063009 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063009?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063009, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063009?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063009?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063009?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063009?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1062982?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062982. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062982."
    },
    {
        "instruction": "In which chromosome is SNV1062982 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062982?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062982, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062982?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062982?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062982?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062982?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DEL1062978?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062978. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062978."
    },
    {
        "instruction": "In which chromosome is DEL1062978 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062978?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062978, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062978?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062978?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062978?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062978?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1062981?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1062981. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1062981."
    },
    {
        "instruction": "In which chromosome is DUP1062981 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1062981?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1062981, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1062981?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1062981?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1062981?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1062981?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1062986?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062986. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062986."
    },
    {
        "instruction": "In which chromosome is DEL1062986 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062986?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062986, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062986?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062986?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062986?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062986?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with 1062980?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1062980. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1062980."
    },
    {
        "instruction": "In which chromosome is 1062980 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1062980?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1062980, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 1062980?",
        "output": "The variation length is 32 base pairs."
    },
    {
        "instruction": "What is the origin for 1062980?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1062980?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1062980?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1062997?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062997. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062997."
    },
    {
        "instruction": "In which chromosome is DEL1062997 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062997?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062997, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062997?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062997?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062997?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062997?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1063005?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1063005. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1063005."
    },
    {
        "instruction": "In which chromosome is DEL1063005 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1063005?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1063005, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1063005?",
        "output": "The variation length is 7 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1063005?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1063005?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1063005?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062983?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062983. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062983."
    },
    {
        "instruction": "In which chromosome is SNV1062983 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062983?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062983, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062983?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062983?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062983?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062983?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DEL1062985?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062985. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062985."
    },
    {
        "instruction": "In which chromosome is DEL1062985 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062985?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062985, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062985?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062985?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062985?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062985?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS753349760 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS753349760 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS753349760 SNP."
    },
    {
        "instruction": "In which chromosome is RS753349760 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS753349760 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS753349760 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS753349760 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS753349760 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS753349760 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS753349760 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080088?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080088. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080088."
    },
    {
        "instruction": "In which chromosome is SNV1080088 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080088?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080088, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080088?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080088?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080088?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080088?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080093?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080093. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080093."
    },
    {
        "instruction": "In which chromosome is SNV1080093 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080093?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080093, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080093?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080093?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080093?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080093?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080107?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080107. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080107."
    },
    {
        "instruction": "In which chromosome is SNV1080107 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080107?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080107, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080107?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080107?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080107?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080107?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555293650 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555293650 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555293650 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555293650 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555293650 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555293650 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555293650 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555293650 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555293650 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555293650 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080085?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080085. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080085."
    },
    {
        "instruction": "In which chromosome is SNV1080085 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080085?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080085, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080085?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080085?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080085?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080085?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080110?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080110. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080110."
    },
    {
        "instruction": "In which chromosome is SNV1080110 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080110?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080110, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080110?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080110?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080110?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080110?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS753520981 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS753520981 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS753520981 SNP."
    },
    {
        "instruction": "In which chromosome is RS753520981 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS753520981 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS753520981 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS753520981 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS753520981 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS753520981 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS753520981 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080089?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080089. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080089."
    },
    {
        "instruction": "In which chromosome is SNV1080089 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080089?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080089, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080089?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080089?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080089?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080089?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080102?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080102. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080102."
    },
    {
        "instruction": "In which chromosome is SNV1080102 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080102?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080102, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080102?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080102?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080102?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080102?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080086?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080086. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080086."
    },
    {
        "instruction": "In which chromosome is SNV1080086 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080086?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080086, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080086?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080086?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080086?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080086?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080104?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080104. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080104."
    },
    {
        "instruction": "In which chromosome is SNV1080104 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080104?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080104, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080104?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080104?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080104?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080104?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1356053052 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1356053052 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1356053052 SNP."
    },
    {
        "instruction": "In which chromosome is RS1356053052 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1356053052 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1356053052 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1356053052 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1356053052 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1356053052 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1356053052 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593547157 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593547157 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593547157 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593547157 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593547157 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593547157 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593547157 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593547157 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593547157 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593547157 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080095?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080095. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080095."
    },
    {
        "instruction": "In which chromosome is SNV1080095 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080095?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080095, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080095?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080095?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080095?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080095?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080092?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080092. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080092."
    },
    {
        "instruction": "In which chromosome is SNV1080092 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080092?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080092, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080092?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080092?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080092?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080092?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080091?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080091. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080091."
    },
    {
        "instruction": "In which chromosome is SNV1080091 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080091?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080091, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080091?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080091?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080091?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080091?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080098?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080098. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080098."
    },
    {
        "instruction": "In which chromosome is SNV1080098 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080098?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080098, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080098?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080098?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080098?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080098?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080100?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080100. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080100."
    },
    {
        "instruction": "In which chromosome is SNV1080100 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080100?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080100, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080100?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080100?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080100?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080100?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080099?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080099. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080099."
    },
    {
        "instruction": "In which chromosome is SNV1080099 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080099?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080099, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080099?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080099?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080099?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080099?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080109?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080109. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080109."
    },
    {
        "instruction": "In which chromosome is SNV1080109 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080109?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080109, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080109?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080109?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080109?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080109?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080090?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080090. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080090."
    },
    {
        "instruction": "In which chromosome is SNV1080090 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080090?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080090, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080090?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080090?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080090?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080090?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080101?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080101. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080101."
    },
    {
        "instruction": "In which chromosome is SNV1080101 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080101?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080101, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080101?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080101?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080101?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080101?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080108?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080108. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080108."
    },
    {
        "instruction": "In which chromosome is SNV1080108 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080108?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080108, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080108?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080108?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080108?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080108?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080111?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080111. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080111."
    },
    {
        "instruction": "In which chromosome is SNV1080111 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080111?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080111, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080111?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080111?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080111?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080111?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080096?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080096. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080096."
    },
    {
        "instruction": "In which chromosome is SNV1080096 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080096?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080096, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080096?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080096?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080096?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080096?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080106?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080106. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080106."
    },
    {
        "instruction": "In which chromosome is SNV1080106 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080106?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080106, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080106?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080106?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080106?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080106?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080094?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080094. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080094."
    },
    {
        "instruction": "In which chromosome is SNV1080094 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080094?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080094, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080094?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080094?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080094?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080094?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080105?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080105. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080105."
    },
    {
        "instruction": "In which chromosome is SNV1080105 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080105?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080105, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080105?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080105?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080105?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080105?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101882?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101882. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101882."
    },
    {
        "instruction": "In which chromosome is SNV1101882 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101882?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101882, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101882?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101882?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101882?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101882?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101897?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101897. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101897."
    },
    {
        "instruction": "In which chromosome is SNV1101897 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101897?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101897, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101897?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101897?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101897?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101897?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101906?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101906. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101906."
    },
    {
        "instruction": "In which chromosome is SNV1101906 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101906?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101906, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101906?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101906?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101906?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101906?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101909?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101909. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101909."
    },
    {
        "instruction": "In which chromosome is SNV1101909 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101909?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101909, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101909?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101909?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101909?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101909?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101904?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101904. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101904."
    },
    {
        "instruction": "In which chromosome is SNV1101904 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101904?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101904, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101904?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101904?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101904?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101904?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101883?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101883. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101883."
    },
    {
        "instruction": "In which chromosome is SNV1101883 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101883?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101883, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101883?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101883?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101883?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101883?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101896?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101896. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101896."
    },
    {
        "instruction": "In which chromosome is SNV1101896 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101896?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101896, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101896?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101896?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101896?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101896?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101880?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101880. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101880."
    },
    {
        "instruction": "In which chromosome is SNV1101880 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101880?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101880, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101880?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101880?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101880?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101880?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101888?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101888. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101888."
    },
    {
        "instruction": "In which chromosome is SNV1101888 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101888?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101888, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101888?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101888?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101888?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101888?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101886?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101886. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101886."
    },
    {
        "instruction": "In which chromosome is SNV1101886 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101886?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101886, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101886?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101886?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101886?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101886?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101881?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101881. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101881."
    },
    {
        "instruction": "In which chromosome is SNV1101881 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101881?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101881, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101881?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101881?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101881?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101881?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1101890?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1101890. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1101890."
    },
    {
        "instruction": "In which chromosome is DEL1101890 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1101890?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1101890, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1101890?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1101890?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1101890?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1101890?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101901?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101901. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101901."
    },
    {
        "instruction": "In which chromosome is SNV1101901 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101901?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101901, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101901?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101901?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101901?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101901?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS746361171 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746361171 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746361171 SNP."
    },
    {
        "instruction": "In which chromosome is RS746361171 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746361171 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746361171 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS746361171 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS746361171 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746361171 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746361171 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593411934 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593411934 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593411934 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593411934 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593411934 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593411934 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593411934 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593411934 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593411934 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593411934 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101884?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101884. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101884."
    },
    {
        "instruction": "In which chromosome is SNV1101884 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101884?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101884, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101884?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101884?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101884?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101884?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS770728170 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770728170 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770728170 SNP."
    },
    {
        "instruction": "In which chromosome is RS770728170 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770728170 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770728170 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS770728170 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770728170 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770728170 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770728170 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101908?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101908. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101908."
    },
    {
        "instruction": "In which chromosome is SNV1101908 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101908?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101908, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101908?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101908?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101908?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101908?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101910?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101910. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101910."
    },
    {
        "instruction": "In which chromosome is SNV1101910 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101910?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101910, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101910?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101910?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101910?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101910?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101900?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101900. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101900."
    },
    {
        "instruction": "In which chromosome is SNV1101900 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101900?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101900, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101900?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101900?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101900?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101900?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101885?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101885. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101885."
    },
    {
        "instruction": "In which chromosome is SNV1101885 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101885?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101885, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101885?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101885?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101885?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101885?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101893?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101893. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101893."
    },
    {
        "instruction": "In which chromosome is SNV1101893 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101893?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101893, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101893?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101893?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101893?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101893?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101892?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101892. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101892."
    },
    {
        "instruction": "In which chromosome is SNV1101892 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101892?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101892, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101892?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101892?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101892?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101892?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101905?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101905. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101905."
    },
    {
        "instruction": "In which chromosome is SNV1101905 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101905?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101905, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101905?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101905?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101905?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101905?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101903?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101903. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101903."
    },
    {
        "instruction": "In which chromosome is SNV1101903 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101903?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101903, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101903?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101903?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101903?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101903?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1101898?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1101898. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1101898."
    },
    {
        "instruction": "In which chromosome is DUP1101898 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1101898?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1101898, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DUP1101898?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1101898?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1101898?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1101898?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101895?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101895. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101895."
    },
    {
        "instruction": "In which chromosome is SNV1101895 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101895?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101895, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101895?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101895?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101895?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101895?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101907?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101907. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101907."
    },
    {
        "instruction": "In which chromosome is SNV1101907 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101907?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101907, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101907?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101907?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101907?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101907?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101887?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101887. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101887."
    },
    {
        "instruction": "In which chromosome is SNV1101887 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101887?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101887, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101887?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101887?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101887?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101887?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123355?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123355. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123355."
    },
    {
        "instruction": "In which chromosome is SNV1123355 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123355?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123355, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123355?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123355?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123355?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123355?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123367?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123367. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123367."
    },
    {
        "instruction": "In which chromosome is SNV1123367 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123367?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123367, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123367?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123367?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123367?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123367?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123345?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123345. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123345."
    },
    {
        "instruction": "In which chromosome is SNV1123345 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123345?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123345, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123345?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123345?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123345?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123345?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123354?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123354. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123354."
    },
    {
        "instruction": "In which chromosome is SNV1123354 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123354?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123354, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123354?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123354?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123354?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123354?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123372?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123372. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123372."
    },
    {
        "instruction": "In which chromosome is SNV1123372 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123372?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123372, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123372?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123372?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123372?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123372?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593547215 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593547215 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593547215 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593547215 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593547215 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593547215 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593547215 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593547215 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593547215 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593547215 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123349?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123349. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123349."
    },
    {
        "instruction": "In which chromosome is SNV1123349 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123349?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123349, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123349?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123349?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123349?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123349?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123343?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123343. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123343."
    },
    {
        "instruction": "In which chromosome is SNV1123343 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123343?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123343, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123343?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123343?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123343?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123343?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123362?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123362. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123362."
    },
    {
        "instruction": "In which chromosome is SNV1123362 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123362?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123362, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123362?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123362?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123362?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123362?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123341?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123341. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123341."
    },
    {
        "instruction": "In which chromosome is SNV1123341 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123341?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123341, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123341?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123341?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123341?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123341?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123351?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123351. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123351."
    },
    {
        "instruction": "In which chromosome is SNV1123351 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123351?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123351, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123351?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123351?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123351?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123351?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123370?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123370. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123370."
    },
    {
        "instruction": "In which chromosome is SNV1123370 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123370?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123370, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123370?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123370?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123370?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123370?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123344?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123344. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123344."
    },
    {
        "instruction": "In which chromosome is SNV1123344 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123344?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123344, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123344?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123344?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123344?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123344?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123369?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123369. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123369."
    },
    {
        "instruction": "In which chromosome is SNV1123369 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123369?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123369, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123369?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123369?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123369?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123369?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123348?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123348. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123348."
    },
    {
        "instruction": "In which chromosome is SNV1123348 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123348?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123348, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123348?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123348?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123348?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123348?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123360?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123360. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123360."
    },
    {
        "instruction": "In which chromosome is SNV1123360 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123360?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123360, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123360?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123360?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123360?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123360?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS750305249 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750305249 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750305249 SNP."
    },
    {
        "instruction": "In which chromosome is RS750305249 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750305249 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750305249 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750305249 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750305249 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750305249 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750305249 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123356?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123356. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123356."
    },
    {
        "instruction": "In which chromosome is SNV1123356 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123356?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123356, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123356?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123356?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123356?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123356?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123352?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123352. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123352."
    },
    {
        "instruction": "In which chromosome is SNV1123352 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123352?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123352, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123352?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123352?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123352?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123352?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123353?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123353. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123353."
    },
    {
        "instruction": "In which chromosome is SNV1123353 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123353?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123353, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123353?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123353?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123353?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123353?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123342?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123342. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123342."
    },
    {
        "instruction": "In which chromosome is SNV1123342 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123342?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123342, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123342?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123342?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123342?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123342?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1484231598 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1484231598 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1484231598 SNP."
    },
    {
        "instruction": "In which chromosome is RS1484231598 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1484231598 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1484231598 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1484231598 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1484231598 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1484231598 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1484231598 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS751718011 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751718011 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751718011 SNP."
    },
    {
        "instruction": "In which chromosome is RS751718011 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751718011 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751718011 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS751718011 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751718011 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751718011 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751718011 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123340?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123340. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123340."
    },
    {
        "instruction": "In which chromosome is SNV1123340 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123340?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123340, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123340?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123340?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123340?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123340?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123346?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123346. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123346."
    },
    {
        "instruction": "In which chromosome is SNV1123346 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123346?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123346, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123346?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123346?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123346?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123346?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123364?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123364. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123364."
    },
    {
        "instruction": "In which chromosome is SNV1123364 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123364?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123364, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123364?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123364?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123364?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123364?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123361?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123361. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123361."
    },
    {
        "instruction": "In which chromosome is SNV1123361 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123361?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123361, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123361?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123361?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123361?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123361?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123368?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123368. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123368."
    },
    {
        "instruction": "In which chromosome is SNV1123368 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123368?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123368, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123368?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123368?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123368?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123368?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123366?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123366. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123366."
    },
    {
        "instruction": "In which chromosome is SNV1123366 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123366?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123366, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123366?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123366?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123366?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123366?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123365?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123365. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123365."
    },
    {
        "instruction": "In which chromosome is SNV1123365 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123365?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123365, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123365?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123365?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123365?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123365?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123359?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123359. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123359."
    },
    {
        "instruction": "In which chromosome is SNV1123359 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123359?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123359, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123359?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123359?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123359?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123359?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS762588468 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762588468 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762588468 SNP."
    },
    {
        "instruction": "In which chromosome is RS762588468 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762588468 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762588468 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS762588468 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762588468 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762588468 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762588468 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593434172 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434172 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434172 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434172 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434172 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434172 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593434172 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434172 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434172 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434172 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144232?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144232. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144232."
    },
    {
        "instruction": "In which chromosome is SNV1144232 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144232?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144232, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144232?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144232?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144232?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144232?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144221?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144221. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144221."
    },
    {
        "instruction": "In which chromosome is SNV1144221 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144221?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144221, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144221?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144221?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144221?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144221?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS779180897 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS779180897 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS779180897 SNP."
    },
    {
        "instruction": "In which chromosome is RS779180897 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS779180897 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS779180897 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS779180897 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS779180897 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS779180897 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS779180897 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS771369373 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS771369373 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS771369373 SNP."
    },
    {
        "instruction": "In which chromosome is RS771369373 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS771369373 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS771369373 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS771369373 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS771369373 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS771369373 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS771369373 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144224?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144224. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144224."
    },
    {
        "instruction": "In which chromosome is SNV1144224 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144224?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144224, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144224?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144224?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144224?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144224?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144226?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144226. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144226."
    },
    {
        "instruction": "In which chromosome is SNV1144226 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144226?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144226, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144226?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144226?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144226?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144226?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144235?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144235. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144235."
    },
    {
        "instruction": "In which chromosome is SNV1144235 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144235?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144235, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144235?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144235?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144235?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144235?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144219?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144219. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144219."
    },
    {
        "instruction": "In which chromosome is SNV1144219 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144219?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144219, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144219?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144219?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144219?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144219?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144231?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144231. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144231."
    },
    {
        "instruction": "In which chromosome is SNV1144231 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144231?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144231, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144231?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144231?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144231?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144231?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1254874409 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1254874409 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1254874409 SNP."
    },
    {
        "instruction": "In which chromosome is RS1254874409 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1254874409 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1254874409 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1254874409 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1254874409 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1254874409 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1254874409 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144228?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144228. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144228."
    },
    {
        "instruction": "In which chromosome is SNV1144228 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144228?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144228, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144228?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144228?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144228?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144228?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144217?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144217. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144217."
    },
    {
        "instruction": "In which chromosome is SNV1144217 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144217?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144217, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144217?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144217?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144217?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144217?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144234?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144234. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144234."
    },
    {
        "instruction": "In which chromosome is SNV1144234 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144234?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144234, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144234?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144234?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144234?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144234?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144230?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144230. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144230."
    },
    {
        "instruction": "In which chromosome is SNV1144230 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144230?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144230, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144230?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144230?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144230?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144230?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144223?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144223. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144223."
    },
    {
        "instruction": "In which chromosome is SNV1144223 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144223?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144223, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144223?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144223?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144223?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144223?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144220?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144220. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144220."
    },
    {
        "instruction": "In which chromosome is SNV1144220 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144220?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144220, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144220?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144220?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144220?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144220?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144233?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144233. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144233."
    },
    {
        "instruction": "In which chromosome is SNV1144233 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144233?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144233, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144233?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144233?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144233?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144233?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144222?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144222. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144222."
    },
    {
        "instruction": "In which chromosome is SNV1144222 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144222?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144222, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144222?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144222?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144222?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144222?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144225?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144225. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144225."
    },
    {
        "instruction": "In which chromosome is SNV1144225 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144225?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144225, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144225?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144225?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144225?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144225?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144218?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144218. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144218."
    },
    {
        "instruction": "In which chromosome is SNV1144218 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144218?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144218, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144218?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144218?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144218?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144218?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1157144?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1157144. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1157144."
    },
    {
        "instruction": "In which chromosome is DEL1157144 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1157144?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1157144, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DEL1157144?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1157144?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1157144?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1157144?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1157143?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1157143. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1157143."
    },
    {
        "instruction": "In which chromosome is SNV1157143 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1157143?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1157143, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1157143?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1157143?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1157143?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1157143?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983599?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983599. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983599."
    },
    {
        "instruction": "In which chromosome is SNV983599 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983599?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV983599, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983599?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983599?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983599?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983599?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS483352690 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS483352690 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS483352690 SNP."
    },
    {
        "instruction": "In which chromosome is RS483352690 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS483352690 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS483352690 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS483352690 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS483352690 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS483352690 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS483352690 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS483352689 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS483352689 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS483352689 SNP."
    },
    {
        "instruction": "In which chromosome is RS483352689 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS483352689 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS483352689 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS483352689 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS483352689 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS483352689 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS483352689 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS145729675 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS145729675 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS145729675 SNP."
    },
    {
        "instruction": "In which chromosome is RS145729675 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS145729675 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS145729675 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS145729675 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS145729675 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS145729675 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS145729675 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532019 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532019 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532019 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532019 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532019 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532019 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593532019 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532019 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532019 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532019 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1372842030 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1372842030 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1372842030 SNP."
    },
    {
        "instruction": "In which chromosome is RS1372842030 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1372842030 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1372842030 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1372842030 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1372842030 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1372842030 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1372842030 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1220980701 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1220980701 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1220980701 SNP."
    },
    {
        "instruction": "In which chromosome is RS1220980701 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1220980701 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1220980701 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1220980701 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1220980701 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1220980701 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1220980701 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593549718 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593549718 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593549718 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593549718 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593549718 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593549718 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593549718 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593549718 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593549718 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593549718 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412070 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412070 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412070 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412070 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412070 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412070 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412070 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412070 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412070 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412070 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412158 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412158 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412158 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412158 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412158 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412158 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412158 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412158 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412158 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412158 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS746954896 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746954896 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746954896 SNP."
    },
    {
        "instruction": "In which chromosome is RS746954896 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746954896 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746954896 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS746954896 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS746954896 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746954896 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746954896 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1499281?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1499281. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1499281."
    },
    {
        "instruction": "In which chromosome is SNV1499281 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1499281?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1499281, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1499281?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1499281?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1499281?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1499281?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1499631?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1499631. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1499631."
    },
    {
        "instruction": "In which chromosome is SNV1499631 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1499631?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1499631, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1499631?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1499631?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1499631?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1499631?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1427453?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1427453. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1427453."
    },
    {
        "instruction": "In which chromosome is SNV1427453 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1427453?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1427453, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1427453?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1427453?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1427453?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1427453?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1363789?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1363789. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1363789."
    },
    {
        "instruction": "In which chromosome is SNV1363789 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1363789?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1363789, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1363789?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1363789?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1363789?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1363789?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1509417?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1509417. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1509417."
    },
    {
        "instruction": "In which chromosome is SNV1509417 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1509417?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1509417, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1509417?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1509417?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1509417?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1509417?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1354292?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1354292. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1354292."
    },
    {
        "instruction": "In which chromosome is SNV1354292 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1354292?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1354292, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1354292?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1354292?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1354292?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1354292?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1424673?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1424673. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1424673."
    },
    {
        "instruction": "In which chromosome is SNV1424673 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1424673?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1424673, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1424673?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1424673?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1424673?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1424673?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1461044?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1461044. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1461044."
    },
    {
        "instruction": "In which chromosome is SNV1461044 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1461044?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1461044, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1461044?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1461044?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1461044?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1461044?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 1038265?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1038265. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1038265."
    },
    {
        "instruction": "In which chromosome is 1038265 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1038265?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1038265, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for 1038265?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for 1038265?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1038265?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1038265?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1370762?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1370762. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1370762."
    },
    {
        "instruction": "In which chromosome is DEL1370762 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1370762?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1370762, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1370762?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1370762?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1370762?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1370762?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS371655281 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371655281 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371655281 SNP."
    },
    {
        "instruction": "In which chromosome is RS371655281 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371655281 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371655281 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS371655281 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371655281 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371655281 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371655281 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593445085 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445085 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445085 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445085 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445085 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445085 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593445085 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445085 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445085 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445085 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1437470?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1437470. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1437470."
    },
    {
        "instruction": "In which chromosome is SNV1437470 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1437470?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1437470, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1437470?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1437470?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1437470?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1437470?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1437630?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1437630. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1437630."
    },
    {
        "instruction": "In which chromosome is SNV1437630 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1437630?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1437630, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1437630?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1437630?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1437630?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1437630?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1486354?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1486354. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1486354."
    },
    {
        "instruction": "In which chromosome is SNV1486354 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1486354?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1486354, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1486354?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1486354?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1486354?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1486354?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1338473?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1338473. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1338473."
    },
    {
        "instruction": "In which chromosome is SNV1338473 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1338473?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1338473, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1338473?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1338473?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1338473?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1338473?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1466617?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1466617. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1466617."
    },
    {
        "instruction": "In which chromosome is SNV1466617 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1466617?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1466617, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1466617?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1466617?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1466617?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1466617?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1476676?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1476676. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1476676."
    },
    {
        "instruction": "In which chromosome is DEL1476676 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1476676?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1476676, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1476676?",
        "output": "The variation length is 104 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1476676?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1476676?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1476676?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1476758?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1476758. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1476758."
    },
    {
        "instruction": "In which chromosome is SNV1476758 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1476758?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1476758, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1476758?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1476758?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1476758?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1476758?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1495900?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1495900. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1495900."
    },
    {
        "instruction": "In which chromosome is SNV1495900 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1495900?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1495900, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1495900?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1495900?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1495900?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1495900?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1373780?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1373780. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1373780."
    },
    {
        "instruction": "In which chromosome is SNV1373780 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1373780?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1373780, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1373780?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1373780?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1373780?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1373780?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1489437?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1489437. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1489437."
    },
    {
        "instruction": "In which chromosome is SNV1489437 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1489437?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1489437, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1489437?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1489437?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1489437?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1489437?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1373631?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1373631. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1373631."
    },
    {
        "instruction": "In which chromosome is SNV1373631 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1373631?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1373631, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1373631?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1373631?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1373631?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1373631?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1396535?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1396535. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1396535."
    },
    {
        "instruction": "In which chromosome is SNV1396535 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1396535?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1396535, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1396535?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1396535?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1396535?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1396535?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1418107?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1418107. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1418107."
    },
    {
        "instruction": "In which chromosome is SNV1418107 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1418107?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1418107, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1418107?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1418107?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1418107?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1418107?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1486606?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1486606. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1486606."
    },
    {
        "instruction": "In which chromosome is SNV1486606 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1486606?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1486606, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1486606?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1486606?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1486606?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1486606?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1421451?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1421451. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1421451."
    },
    {
        "instruction": "In which chromosome is SNV1421451 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1421451?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1421451, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1421451?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1421451?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1421451?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1421451?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1357326?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1357326. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1357326."
    },
    {
        "instruction": "In which chromosome is SNV1357326 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1357326?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1357326, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1357326?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1357326?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1357326?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1357326?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1421468?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1421468. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1421468."
    },
    {
        "instruction": "In which chromosome is SNV1421468 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1421468?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1421468, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1421468?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1421468?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1421468?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1421468?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1422672?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1422672. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1422672."
    },
    {
        "instruction": "In which chromosome is DEL1422672 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1422672?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1422672, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1422672?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1422672?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1422672?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1422672?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1480097?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1480097. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1480097."
    },
    {
        "instruction": "In which chromosome is SNV1480097 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1480097?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1480097, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1480097?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1480097?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1480097?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1480097?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1352580?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1352580. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1352580."
    },
    {
        "instruction": "In which chromosome is SNV1352580 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1352580?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1352580, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1352580?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1352580?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1352580?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1352580?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1389412?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1389412. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1389412."
    },
    {
        "instruction": "In which chromosome is SNV1389412 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1389412?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1389412, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1389412?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1389412?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1389412?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1389412?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1414960?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1414960. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1414960."
    },
    {
        "instruction": "In which chromosome is SNV1414960 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1414960?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1414960, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1414960?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1414960?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1414960?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1414960?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1405664?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1405664. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1405664."
    },
    {
        "instruction": "In which chromosome is SNV1405664 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1405664?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1405664, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1405664?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1405664?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1405664?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1405664?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1480509?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1480509. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1480509."
    },
    {
        "instruction": "In which chromosome is SNV1480509 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1480509?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1480509, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1480509?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1480509?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1480509?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1480509?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1367703?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1367703. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1367703."
    },
    {
        "instruction": "In which chromosome is DUP1367703 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1367703?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1367703, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1367703?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1367703?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1367703?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1367703?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1409091?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1409091. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1409091."
    },
    {
        "instruction": "In which chromosome is DEL1409091 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1409091?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1409091, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1409091?",
        "output": "The variation length is 26 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1409091?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1409091?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1409091?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1409111?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1409111. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1409111."
    },
    {
        "instruction": "In which chromosome is SNV1409111 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1409111?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1409111, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1409111?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1409111?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1409111?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1409111?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1383406?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1383406. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1383406."
    },
    {
        "instruction": "In which chromosome is SNV1383406 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1383406?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1383406, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1383406?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1383406?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1383406?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1383406?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1502205?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1502205. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1502205."
    },
    {
        "instruction": "In which chromosome is SNV1502205 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1502205?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1502205, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1502205?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1502205?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1502205?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1502205?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1440019?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1440019. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1440019."
    },
    {
        "instruction": "In which chromosome is SNV1440019 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1440019?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1440019, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1440019?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1440019?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1440019?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1440019?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1421786?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1421786. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1421786."
    },
    {
        "instruction": "In which chromosome is SNV1421786 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1421786?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1421786, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1421786?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1421786?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1421786?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1421786?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1489552?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1489552. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1489552."
    },
    {
        "instruction": "In which chromosome is DEL1489552 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1489552?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1489552, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1489552?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1489552?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1489552?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1489552?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1402731?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1402731. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1402731."
    },
    {
        "instruction": "In which chromosome is SNV1402731 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1402731?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1402731, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1402731?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1402731?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1402731?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1402731?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1340440?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1340440. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1340440."
    },
    {
        "instruction": "In which chromosome is SNV1340440 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1340440?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1340440, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1340440?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1340440?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1340440?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1340440?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1427820?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1427820. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1427820."
    },
    {
        "instruction": "In which chromosome is SNV1427820 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1427820?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1427820, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1427820?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1427820?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1427820?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1427820?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1376944?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1376944. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1376944."
    },
    {
        "instruction": "In which chromosome is SNV1376944 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1376944?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1376944, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1376944?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1376944?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1376944?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1376944?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1349103?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1349103. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1349103."
    },
    {
        "instruction": "In which chromosome is DEL1349103 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1349103?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1349103, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1349103?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1349103?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1349103?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1349103?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1337450?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1337450. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1337450."
    },
    {
        "instruction": "In which chromosome is SNV1337450 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1337450?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1337450, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1337450?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1337450?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1337450?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1337450?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1412560?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1412560. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1412560."
    },
    {
        "instruction": "In which chromosome is SNV1412560 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1412560?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1412560, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1412560?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1412560?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1412560?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1412560?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1350746?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1350746. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1350746."
    },
    {
        "instruction": "In which chromosome is SNV1350746 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1350746?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1350746, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1350746?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1350746?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1350746?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1350746?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1414993?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1414993. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1414993."
    },
    {
        "instruction": "In which chromosome is DEL1414993 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1414993?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1414993, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1414993?",
        "output": "The variation length is 38 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1414993?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1414993?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1414993?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1434856?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1434856. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1434856."
    },
    {
        "instruction": "In which chromosome is SNV1434856 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1434856?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1434856, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1434856?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1434856?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1434856?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1434856?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1349123?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1349123. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1349123."
    },
    {
        "instruction": "In which chromosome is SNV1349123 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1349123?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1349123, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1349123?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1349123?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1349123?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1349123?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1349349?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1349349. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1349349."
    },
    {
        "instruction": "In which chromosome is SNV1349349 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1349349?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1349349, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1349349?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1349349?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1349349?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1349349?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1344607?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1344607. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1344607."
    },
    {
        "instruction": "In which chromosome is SNV1344607 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1344607?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1344607, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1344607?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1344607?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1344607?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1344607?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1353390?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1353390. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1353390."
    },
    {
        "instruction": "In which chromosome is SNV1353390 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1353390?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1353390, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1353390?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1353390?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1353390?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1353390?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1348658?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1348658. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1348658."
    },
    {
        "instruction": "In which chromosome is SNV1348658 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1348658?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1348658, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1348658?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1348658?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1348658?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1348658?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1425391?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1425391. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1425391."
    },
    {
        "instruction": "In which chromosome is SNV1425391 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1425391?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1425391, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1425391?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1425391?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1425391?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1425391?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1422610?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1422610. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1422610."
    },
    {
        "instruction": "In which chromosome is SNV1422610 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1422610?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1422610, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1422610?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1422610?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1422610?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1422610?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1483933?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1483933. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1483933."
    },
    {
        "instruction": "In which chromosome is SNV1483933 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1483933?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1483933, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1483933?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1483933?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1483933?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1483933?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1513472?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1513472. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1513472."
    },
    {
        "instruction": "In which chromosome is SNV1513472 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1513472?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1513472, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1513472?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1513472?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1513472?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1513472?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1397268?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1397268. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1397268."
    },
    {
        "instruction": "In which chromosome is SNV1397268 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1397268?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1397268, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1397268?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1397268?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1397268?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1397268?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1490106?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1490106. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1490106."
    },
    {
        "instruction": "In which chromosome is SNV1490106 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1490106?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1490106, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1490106?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1490106?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1490106?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1490106?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1405129?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1405129. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1405129."
    },
    {
        "instruction": "In which chromosome is SNV1405129 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1405129?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1405129, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1405129?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1405129?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1405129?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1405129?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1444620?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1444620. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1444620."
    },
    {
        "instruction": "In which chromosome is SNV1444620 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1444620?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1444620, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1444620?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1444620?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1444620?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1444620?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1510505?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1510505. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1510505."
    },
    {
        "instruction": "In which chromosome is SNV1510505 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1510505?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1510505, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1510505?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1510505?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1510505?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1510505?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1489047?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1489047. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1489047."
    },
    {
        "instruction": "In which chromosome is SNV1489047 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1489047?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1489047, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1489047?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1489047?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1489047?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1489047?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1463895?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1463895. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1463895."
    },
    {
        "instruction": "In which chromosome is SNV1463895 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1463895?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1463895, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1463895?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1463895?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1463895?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1463895?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1500247?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1500247. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1500247."
    },
    {
        "instruction": "In which chromosome is SNV1500247 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1500247?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1500247, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1500247?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1500247?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1500247?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1500247?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1377714?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1377714. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1377714."
    },
    {
        "instruction": "In which chromosome is SNV1377714 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1377714?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1377714, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1377714?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1377714?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1377714?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1377714?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1374070?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1374070. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1374070."
    },
    {
        "instruction": "In which chromosome is SNV1374070 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1374070?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1374070, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1374070?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1374070?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1374070?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1374070?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1445138?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1445138. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1445138."
    },
    {
        "instruction": "In which chromosome is DEL1445138 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1445138?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1445138, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1445138?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1445138?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1445138?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1445138?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1390313?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1390313. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1390313."
    },
    {
        "instruction": "In which chromosome is SNV1390313 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1390313?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1390313, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1390313?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1390313?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1390313?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1390313?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1366902?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1366902. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1366902."
    },
    {
        "instruction": "In which chromosome is SNV1366902 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1366902?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1366902, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1366902?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1366902?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1366902?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1366902?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with DEL1444749?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1444749. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1444749."
    },
    {
        "instruction": "In which chromosome is DEL1444749 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1444749?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1444749, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1444749?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1444749?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1444749?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1444749?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1343515?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1343515. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1343515."
    },
    {
        "instruction": "In which chromosome is SNV1343515 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1343515?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1343515, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1343515?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1343515?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1343515?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1343515?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1497507?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1497507. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1497507."
    },
    {
        "instruction": "In which chromosome is SNV1497507 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1497507?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1497507, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1497507?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1497507?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1497507?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1497507?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1435796?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1435796. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1435796."
    },
    {
        "instruction": "In which chromosome is SNV1435796 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1435796?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1435796, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1435796?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1435796?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1435796?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1435796?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1380279?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1380279. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1380279."
    },
    {
        "instruction": "In which chromosome is DUP1380279 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1380279?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1380279, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1380279?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1380279?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1380279?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1380279?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1458139?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1458139. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1458139."
    },
    {
        "instruction": "In which chromosome is SNV1458139 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1458139?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1458139, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1458139?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1458139?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1458139?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1458139?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1477739?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1477739. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1477739."
    },
    {
        "instruction": "In which chromosome is DEL1477739 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1477739?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1477739, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1477739?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1477739?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1477739?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1477739?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1464328?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1464328. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1464328."
    },
    {
        "instruction": "In which chromosome is DUP1464328 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1464328?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1464328, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1464328?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1464328?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1464328?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1464328?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1467490?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1467490. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1467490."
    },
    {
        "instruction": "In which chromosome is SNV1467490 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1467490?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1467490, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1467490?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1467490?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1467490?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1467490?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1510488?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1510488. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1510488."
    },
    {
        "instruction": "In which chromosome is SNV1510488 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1510488?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1510488, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1510488?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1510488?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1510488?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1510488?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1393559?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1393559. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1393559."
    },
    {
        "instruction": "In which chromosome is DEL1393559 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1393559?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1393559, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1393559?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1393559?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1393559?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1393559?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1406197?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1406197. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1406197."
    },
    {
        "instruction": "In which chromosome is DEL1406197 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1406197?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1406197, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1406197?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1406197?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1406197?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1406197?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1380273?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1380273. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1380273."
    },
    {
        "instruction": "In which chromosome is SNV1380273 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1380273?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1380273, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1380273?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1380273?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1380273?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1380273?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1467756?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1467756. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1467756."
    },
    {
        "instruction": "In which chromosome is SNV1467756 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1467756?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1467756, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1467756?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1467756?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1467756?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1467756?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1372023?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1372023. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1372023."
    },
    {
        "instruction": "In which chromosome is SNV1372023 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1372023?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1372023, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1372023?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1372023?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1372023?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1372023?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1393560?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1393560. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1393560."
    },
    {
        "instruction": "In which chromosome is SNV1393560 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1393560?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1393560, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1393560?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1393560?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1393560?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1393560?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1393635?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1393635. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1393635."
    },
    {
        "instruction": "In which chromosome is SNV1393635 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1393635?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1393635, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1393635?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1393635?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1393635?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1393635?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1433173?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1433173. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1433173."
    },
    {
        "instruction": "In which chromosome is SNV1433173 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1433173?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1433173, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1433173?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1433173?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1433173?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1433173?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1390515?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1390515. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1390515."
    },
    {
        "instruction": "In which chromosome is SNV1390515 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1390515?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1390515, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1390515?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1390515?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1390515?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1390515?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1390612?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1390612. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1390612."
    },
    {
        "instruction": "In which chromosome is SNV1390612 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1390612?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1390612, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1390612?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1390612?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1390612?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1390612?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1387060?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1387060. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1387060."
    },
    {
        "instruction": "In which chromosome is SNV1387060 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1387060?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1387060, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1387060?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1387060?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1387060?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1387060?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1506857?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1506857. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1506857."
    },
    {
        "instruction": "In which chromosome is SNV1506857 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1506857?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1506857, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1506857?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1506857?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1506857?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1506857?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1388220?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1388220. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1388220."
    },
    {
        "instruction": "In which chromosome is SNV1388220 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1388220?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1388220, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1388220?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1388220?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1388220?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1388220?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 1468181?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1468181. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1468181."
    },
    {
        "instruction": "In which chromosome is 1468181 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1468181?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1468181, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 1468181?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for 1468181?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1468181?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1468181?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1484869?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1484869. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1484869."
    },
    {
        "instruction": "In which chromosome is DUP1484869 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1484869?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1484869, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1484869?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1484869?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1484869?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1484869?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1346565?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1346565. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1346565."
    },
    {
        "instruction": "In which chromosome is SNV1346565 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1346565?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1346565, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1346565?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1346565?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1346565?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1346565?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1372129?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1372129. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1372129."
    },
    {
        "instruction": "In which chromosome is DEL1372129 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1372129?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1372129, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1372129?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1372129?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1372129?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1372129?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1342381?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1342381. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1342381."
    },
    {
        "instruction": "In which chromosome is SNV1342381 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1342381?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1342381, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1342381?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1342381?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1342381?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1342381?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1359238?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1359238. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1359238."
    },
    {
        "instruction": "In which chromosome is SNV1359238 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1359238?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1359238, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1359238?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1359238?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1359238?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1359238?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1494238?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1494238. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1494238."
    },
    {
        "instruction": "In which chromosome is SNV1494238 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1494238?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1494238, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1494238?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1494238?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1494238?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1494238?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1457637?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1457637. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1457637."
    },
    {
        "instruction": "In which chromosome is SNV1457637 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1457637?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1457637, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1457637?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1457637?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1457637?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1457637?",
        "output": "The resulting gene consequence is a initiatior codon variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1346027?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1346027. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1346027."
    },
    {
        "instruction": "In which chromosome is SNV1346027 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1346027?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1346027, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1346027?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1346027?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1346027?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1346027?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1494530?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1494530. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1494530."
    },
    {
        "instruction": "In which chromosome is SNV1494530 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1494530?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1494530, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1494530?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1494530?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1494530?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1494530?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1388559?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1388559. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1388559."
    },
    {
        "instruction": "In which chromosome is SNV1388559 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1388559?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1388559, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1388559?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1388559?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1388559?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1388559?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1454579?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1454579. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1454579."
    },
    {
        "instruction": "In which chromosome is SNV1454579 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1454579?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1454579, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1454579?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1454579?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1454579?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1454579?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1461975?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1461975. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1461975."
    },
    {
        "instruction": "In which chromosome is SNV1461975 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1461975?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1461975, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1461975?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1461975?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1461975?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1461975?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1507319?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1507319. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1507319."
    },
    {
        "instruction": "In which chromosome is SNV1507319 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1507319?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1507319, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1507319?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1507319?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1507319?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1507319?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1475120?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1475120. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1475120."
    },
    {
        "instruction": "In which chromosome is SNV1475120 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1475120?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1475120, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1475120?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1475120?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1475120?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1475120?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1387688?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1387688. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1387688."
    },
    {
        "instruction": "In which chromosome is DUP1387688 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1387688?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1387688, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP1387688?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1387688?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1387688?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1387688?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with SNV1436652?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1436652. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1436652."
    },
    {
        "instruction": "In which chromosome is SNV1436652 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1436652?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1436652, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1436652?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1436652?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1436652?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1436652?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1340902?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1340902. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1340902."
    },
    {
        "instruction": "In which chromosome is SNV1340902 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1340902?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1340902, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1340902?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1340902?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1340902?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1340902?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1488431?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1488431. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1488431."
    },
    {
        "instruction": "In which chromosome is SNV1488431 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1488431?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1488431, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1488431?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1488431?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1488431?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1488431?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1388676?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1388676. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1388676."
    },
    {
        "instruction": "In which chromosome is DEL1388676 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1388676?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1388676, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1388676?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1388676?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1388676?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1388676?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1397954?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1397954. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1397954."
    },
    {
        "instruction": "In which chromosome is SNV1397954 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1397954?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1397954, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1397954?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1397954?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1397954?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1397954?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1416780?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1416780. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1416780."
    },
    {
        "instruction": "In which chromosome is SNV1416780 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1416780?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1416780, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1416780?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1416780?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1416780?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1416780?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1498423?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1498423. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1498423."
    },
    {
        "instruction": "In which chromosome is SNV1498423 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1498423?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1498423, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1498423?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1498423?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1498423?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1498423?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1388291?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1388291. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1388291."
    },
    {
        "instruction": "In which chromosome is SNV1388291 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1388291?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1388291, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1388291?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1388291?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1388291?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1388291?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1405914?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1405914. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1405914."
    },
    {
        "instruction": "In which chromosome is SNV1405914 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1405914?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1405914, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1405914?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1405914?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1405914?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1405914?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1355469?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1355469. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1355469."
    },
    {
        "instruction": "In which chromosome is SNV1355469 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1355469?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1355469, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1355469?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1355469?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1355469?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1355469?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1449363?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1449363. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1449363."
    },
    {
        "instruction": "In which chromosome is SNV1449363 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1449363?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1449363, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1449363?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1449363?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1449363?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1449363?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1497179?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1497179. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1497179."
    },
    {
        "instruction": "In which chromosome is SNV1497179 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1497179?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1497179, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1497179?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1497179?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1497179?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1497179?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1412943?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1412943. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1412943."
    },
    {
        "instruction": "In which chromosome is DUP1412943 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1412943?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1412943, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1412943?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1412943?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1412943?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1412943?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1511176?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1511176. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1511176."
    },
    {
        "instruction": "In which chromosome is SNV1511176 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1511176?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1511176, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1511176?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1511176?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1511176?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1511176?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1426035?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1426035. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1426035."
    },
    {
        "instruction": "In which chromosome is SNV1426035 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1426035?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1426035, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1426035?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1426035?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1426035?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1426035?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1451234?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1451234. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1451234."
    },
    {
        "instruction": "In which chromosome is DEL1451234 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1451234?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1451234, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1451234?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1451234?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1451234?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1451234?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1410269?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1410269. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1410269."
    },
    {
        "instruction": "In which chromosome is SNV1410269 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1410269?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1410269, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1410269?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1410269?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1410269?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1410269?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1423245?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1423245. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1423245."
    },
    {
        "instruction": "In which chromosome is SNV1423245 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1423245?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1423245, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1423245?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1423245?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1423245?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1423245?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1508026?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1508026. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1508026."
    },
    {
        "instruction": "In which chromosome is SNV1508026 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1508026?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1508026, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1508026?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1508026?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1508026?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1508026?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1339323?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1339323. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1339323."
    },
    {
        "instruction": "In which chromosome is SNV1339323 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1339323?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1339323, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1339323?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1339323?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1339323?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1339323?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1380487?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1380487. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1380487."
    },
    {
        "instruction": "In which chromosome is SNV1380487 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1380487?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1380487, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1380487?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1380487?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1380487?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1380487?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1339845?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1339845. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1339845."
    },
    {
        "instruction": "In which chromosome is SNV1339845 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1339845?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1339845, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1339845?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1339845?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1339845?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1339845?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1428551?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1428551. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1428551."
    },
    {
        "instruction": "In which chromosome is DEL1428551 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1428551?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1428551, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1428551?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1428551?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1428551?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1428551?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1497481?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1497481. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1497481."
    },
    {
        "instruction": "In which chromosome is SNV1497481 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1497481?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1497481, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1497481?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1497481?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1497481?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1497481?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1428774?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1428774. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1428774."
    },
    {
        "instruction": "In which chromosome is SNV1428774 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1428774?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1428774, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1428774?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1428774?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1428774?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1428774?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1428777?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1428777. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1428777."
    },
    {
        "instruction": "In which chromosome is SNV1428777 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1428777?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1428777, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1428777?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1428777?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1428777?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1428777?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with 1501257?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1501257. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1501257."
    },
    {
        "instruction": "In which chromosome is 1501257 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1501257?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1501257, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for 1501257?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for 1501257?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1501257?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1501257?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with SNV1387889?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1387889. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1387889."
    },
    {
        "instruction": "In which chromosome is SNV1387889 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1387889?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1387889, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1387889?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1387889?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1387889?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1387889?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1426814?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1426814. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1426814."
    },
    {
        "instruction": "In which chromosome is SNV1426814 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1426814?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1426814, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1426814?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1426814?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1426814?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1426814?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1504776?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1504776. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1504776."
    },
    {
        "instruction": "In which chromosome is SNV1504776 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1504776?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1504776, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1504776?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1504776?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1504776?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1504776?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1420099?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1420099. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1420099."
    },
    {
        "instruction": "In which chromosome is SNV1420099 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1420099?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1420099, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1420099?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1420099?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1420099?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1420099?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1389173?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1389173. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1389173."
    },
    {
        "instruction": "In which chromosome is SNV1389173 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1389173?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1389173, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1389173?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1389173?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1389173?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1389173?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1403637?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1403637. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1403637."
    },
    {
        "instruction": "In which chromosome is SNV1403637 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1403637?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1403637, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1403637?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1403637?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1403637?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1403637?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1400401?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1400401. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1400401."
    },
    {
        "instruction": "In which chromosome is DEL1400401 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1400401?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1400401, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1400401?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1400401?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1400401?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1400401?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1338665?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1338665. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1338665."
    },
    {
        "instruction": "In which chromosome is SNV1338665 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1338665?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1338665, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1338665?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1338665?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1338665?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1338665?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1442884?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1442884. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1442884."
    },
    {
        "instruction": "In which chromosome is SNV1442884 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1442884?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1442884, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1442884?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1442884?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1442884?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1442884?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1443001?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1443001. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1443001."
    },
    {
        "instruction": "In which chromosome is SNV1443001 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1443001?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1443001, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1443001?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1443001?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1443001?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1443001?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1378027?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1378027. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1378027."
    },
    {
        "instruction": "In which chromosome is SNV1378027 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1378027?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1378027, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1378027?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1378027?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1378027?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1378027?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1501867?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1501867. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1501867."
    },
    {
        "instruction": "In which chromosome is SNV1501867 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1501867?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1501867, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1501867?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1501867?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1501867?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1501867?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1380985?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1380985. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1380985."
    },
    {
        "instruction": "In which chromosome is SNV1380985 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1380985?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1380985, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1380985?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1380985?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1380985?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1380985?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1411408?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1411408. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1411408."
    },
    {
        "instruction": "In which chromosome is SNV1411408 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1411408?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1411408, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1411408?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1411408?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1411408?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1411408?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1455528?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1455528. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1455528."
    },
    {
        "instruction": "In which chromosome is SNV1455528 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1455528?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1455528, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1455528?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1455528?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1455528?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1455528?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1482444?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1482444. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1482444."
    },
    {
        "instruction": "In which chromosome is SNV1482444 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1482444?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1482444, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1482444?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1482444?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1482444?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1482444?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1420738?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1420738. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1420738."
    },
    {
        "instruction": "In which chromosome is SNV1420738 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1420738?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1420738, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1420738?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1420738?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1420738?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1420738?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1512392?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1512392. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1512392."
    },
    {
        "instruction": "In which chromosome is SNV1512392 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1512392?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1512392, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1512392?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1512392?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1512392?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1512392?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1478699?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1478699. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1478699."
    },
    {
        "instruction": "In which chromosome is SNV1478699 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1478699?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1478699, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1478699?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1478699?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1478699?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1478699?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1407100?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1407100. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1407100."
    },
    {
        "instruction": "In which chromosome is SNV1407100 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1407100?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1407100, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1407100?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1407100?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1407100?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1407100?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1407199?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1407199. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1407199."
    },
    {
        "instruction": "In which chromosome is SNV1407199 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1407199?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1407199, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1407199?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1407199?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1407199?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1407199?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1433849?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1433849. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1433849."
    },
    {
        "instruction": "In which chromosome is SNV1433849 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1433849?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1433849, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1433849?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1433849?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1433849?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1433849?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1424201?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1424201. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1424201."
    },
    {
        "instruction": "In which chromosome is SNV1424201 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1424201?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1424201, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1424201?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1424201?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1424201?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1424201?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1515344?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1515344. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1515344."
    },
    {
        "instruction": "In which chromosome is SNV1515344 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1515344?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1515344, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1515344?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1515344?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1515344?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1515344?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1420417?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1420417. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1420417."
    },
    {
        "instruction": "In which chromosome is SNV1420417 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1420417?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1420417, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1420417?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1420417?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1420417?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1420417?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1420548?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1420548. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1420548."
    },
    {
        "instruction": "In which chromosome is SNV1420548 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1420548?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1420548, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1420548?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1420548?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1420548?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1420548?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1382206?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1382206. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1382206."
    },
    {
        "instruction": "In which chromosome is SNV1382206 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1382206?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1382206, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1382206?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1382206?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1382206?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1382206?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1516430?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1516430. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1516430."
    },
    {
        "instruction": "In which chromosome is SNV1516430 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1516430?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1516430, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1516430?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1516430?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1516430?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1516430?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1459715?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1459715. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1459715."
    },
    {
        "instruction": "In which chromosome is SNV1459715 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1459715?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1459715, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1459715?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1459715?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1459715?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1459715?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1344113?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1344113. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1344113."
    },
    {
        "instruction": "In which chromosome is SNV1344113 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1344113?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1344113, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1344113?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1344113?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1344113?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1344113?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1456192?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1456192. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1456192."
    },
    {
        "instruction": "In which chromosome is SNV1456192 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1456192?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1456192, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1456192?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1456192?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1456192?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1456192?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1429606?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1429606. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1429606."
    },
    {
        "instruction": "In which chromosome is SNV1429606 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1429606?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1429606, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1429606?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1429606?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1429606?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1429606?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1426135?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1426135. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1426135."
    },
    {
        "instruction": "In which chromosome is DUP1426135 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1426135?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1426135, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1426135?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1426135?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1426135?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1426135?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1395464?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1395464. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1395464."
    },
    {
        "instruction": "In which chromosome is SNV1395464 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1395464?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1395464, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1395464?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1395464?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1395464?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1395464?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1432030?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1432030. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1432030."
    },
    {
        "instruction": "In which chromosome is DEL1432030 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1432030?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1432030, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1432030?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1432030?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1432030?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1432030?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1499059?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1499059. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1499059."
    },
    {
        "instruction": "In which chromosome is SNV1499059 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1499059?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1499059, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1499059?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1499059?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1499059?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1499059?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1486096?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1486096. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1486096."
    },
    {
        "instruction": "In which chromosome is SNV1486096 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1486096?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1486096, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1486096?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1486096?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1486096?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1486096?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1396016?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1396016. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1396016."
    },
    {
        "instruction": "In which chromosome is SNV1396016 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1396016?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1396016, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1396016?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1396016?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1396016?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1396016?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1465792?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1465792. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1465792."
    },
    {
        "instruction": "In which chromosome is SNV1465792 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1465792?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1465792, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1465792?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1465792?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1465792?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1465792?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS148580581 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS148580581 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS148580581 SNP."
    },
    {
        "instruction": "In which chromosome is RS148580581 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS148580581 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS148580581 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS148580581 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS148580581 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS148580581 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS148580581 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS913654931 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS913654931 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS913654931 SNP."
    },
    {
        "instruction": "In which chromosome is RS913654931 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS913654931 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS913654931 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS913654931 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS913654931 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS913654931 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS913654931 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS794727372 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS794727372 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS794727372 SNP."
    },
    {
        "instruction": "In which chromosome is RS794727372 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS794727372 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS794727372 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS794727372 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS794727372 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS794727372 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS794727372 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593544633 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593544633 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593544633 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593544633 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593544633 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593544633 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593544633 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593544633 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593544633 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593544633 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS936709957 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS936709957 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS936709957 SNP."
    },
    {
        "instruction": "In which chromosome is RS936709957 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS936709957 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS936709957 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS936709957 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS936709957 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS936709957 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS936709957 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1212481028 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1212481028 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1212481028 SNP."
    },
    {
        "instruction": "In which chromosome is RS1212481028 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1212481028 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1212481028 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1212481028 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1212481028 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1212481028 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1212481028 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1603396?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1603396. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1603396."
    },
    {
        "instruction": "In which chromosome is SNV1603396 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1603396?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1603396, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1603396?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1603396?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1603396?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1603396?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1581500?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1581500. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1581500."
    },
    {
        "instruction": "In which chromosome is SNV1581500 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1581500?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1581500, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1581500?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1581500?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1581500?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1581500?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1526584?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1526584. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1526584."
    },
    {
        "instruction": "In which chromosome is SNV1526584 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1526584?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1526584, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1526584?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1526584?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1526584?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1526584?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1551813?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1551813. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1551813."
    },
    {
        "instruction": "In which chromosome is SNV1551813 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1551813?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1551813, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1551813?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1551813?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1551813?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1551813?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1653317?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1653317. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1653317."
    },
    {
        "instruction": "In which chromosome is SNV1653317 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1653317?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1653317, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1653317?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1653317?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1653317?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1653317?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1581810?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1581810. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1581810."
    },
    {
        "instruction": "In which chromosome is SNV1581810 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1581810?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1581810, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1581810?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1581810?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1581810?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1581810?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1596112?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1596112. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1596112."
    },
    {
        "instruction": "In which chromosome is SNV1596112 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1596112?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1596112, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1596112?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1596112?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1596112?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1596112?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1648550?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1648550. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1648550."
    },
    {
        "instruction": "In which chromosome is SNV1648550 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1648550?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1648550, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1648550?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1648550?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1648550?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1648550?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1587031?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1587031. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1587031."
    },
    {
        "instruction": "In which chromosome is SNV1587031 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1587031?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1587031, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1587031?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1587031?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1587031?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1587031?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1663894?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1663894. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1663894."
    },
    {
        "instruction": "In which chromosome is SNV1663894 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1663894?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1663894, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1663894?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1663894?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1663894?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1663894?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1614515?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1614515. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1614515."
    },
    {
        "instruction": "In which chromosome is SNV1614515 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1614515?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1614515, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1614515?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1614515?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1614515?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1614515?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1665324?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1665324. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1665324."
    },
    {
        "instruction": "In which chromosome is SNV1665324 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1665324?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1665324, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1665324?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1665324?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1665324?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1665324?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1665493?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1665493. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1665493."
    },
    {
        "instruction": "In which chromosome is SNV1665493 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1665493?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1665493, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1665493?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1665493?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1665493?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1665493?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1522329?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1522329. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1522329."
    },
    {
        "instruction": "In which chromosome is SNV1522329 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1522329?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1522329, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1522329?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1522329?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1522329?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1522329?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1548648?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1548648. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1548648."
    },
    {
        "instruction": "In which chromosome is SNV1548648 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1548648?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1548648, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1548648?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1548648?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1548648?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1548648?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1615203?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1615203. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1615203."
    },
    {
        "instruction": "In which chromosome is SNV1615203 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1615203?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1615203, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1615203?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1615203?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1615203?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1615203?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1584509?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1584509. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1584509."
    },
    {
        "instruction": "In which chromosome is SNV1584509 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1584509?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1584509, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1584509?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1584509?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1584509?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1584509?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1613900?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1613900. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1613900."
    },
    {
        "instruction": "In which chromosome is SNV1613900 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1613900?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1613900, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1613900?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1613900?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1613900?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1613900?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1666153?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1666153. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1666153."
    },
    {
        "instruction": "In which chromosome is SNV1666153 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1666153?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1666153, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1666153?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1666153?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1666153?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1666153?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1521083?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1521083. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1521083."
    },
    {
        "instruction": "In which chromosome is SNV1521083 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1521083?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1521083, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1521083?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1521083?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1521083?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1521083?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1647926?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1647926. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1647926."
    },
    {
        "instruction": "In which chromosome is SNV1647926 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1647926?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1647926, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1647926?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1647926?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1647926?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1647926?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1600521?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1600521. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1600521."
    },
    {
        "instruction": "In which chromosome is SNV1600521 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1600521?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1600521, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1600521?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1600521?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1600521?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1600521?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1587646?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1587646. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1587646."
    },
    {
        "instruction": "In which chromosome is SNV1587646 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1587646?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1587646, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1587646?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1587646?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1587646?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1587646?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1615601?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1615601. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1615601."
    },
    {
        "instruction": "In which chromosome is SNV1615601 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1615601?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1615601, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1615601?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1615601?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1615601?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1615601?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1561204?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1561204. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1561204."
    },
    {
        "instruction": "In which chromosome is SNV1561204 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1561204?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1561204, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1561204?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1561204?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1561204?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1561204?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1540180?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1540180. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1540180."
    },
    {
        "instruction": "In which chromosome is SNV1540180 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1540180?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1540180, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1540180?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1540180?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1540180?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1540180?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1581599?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1581599. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1581599."
    },
    {
        "instruction": "In which chromosome is SNV1581599 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1581599?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1581599, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1581599?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1581599?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1581599?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1581599?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1582031?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1582031. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1582031."
    },
    {
        "instruction": "In which chromosome is SNV1582031 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1582031?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1582031, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1582031?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1582031?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1582031?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1582031?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1635114?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1635114. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1635114."
    },
    {
        "instruction": "In which chromosome is SNV1635114 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1635114?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1635114, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1635114?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1635114?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1635114?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1635114?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1592165?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1592165. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1592165."
    },
    {
        "instruction": "In which chromosome is SNV1592165 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1592165?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1592165, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1592165?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1592165?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1592165?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1592165?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1607501?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1607501. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1607501."
    },
    {
        "instruction": "In which chromosome is SNV1607501 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1607501?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1607501, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1607501?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1607501?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1607501?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1607501?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1629354?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1629354. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1629354."
    },
    {
        "instruction": "In which chromosome is SNV1629354 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1629354?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1629354, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1629354?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1629354?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1629354?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1629354?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1540466?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1540466. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1540466."
    },
    {
        "instruction": "In which chromosome is SNV1540466 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1540466?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1540466, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1540466?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1540466?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1540466?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1540466?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1620416?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1620416. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1620416."
    },
    {
        "instruction": "In which chromosome is SNV1620416 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1620416?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1620416, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1620416?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1620416?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1620416?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1620416?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1594684?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1594684. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1594684."
    },
    {
        "instruction": "In which chromosome is SNV1594684 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1594684?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1594684, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1594684?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1594684?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1594684?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1594684?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1608693?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1608693. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1608693."
    },
    {
        "instruction": "In which chromosome is SNV1608693 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1608693?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1608693, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1608693?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1608693?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1608693?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1608693?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1660999?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1660999. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1660999."
    },
    {
        "instruction": "In which chromosome is SNV1660999 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1660999?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1660999, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1660999?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1660999?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1660999?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1660999?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1589642?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1589642. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1589642."
    },
    {
        "instruction": "In which chromosome is SNV1589642 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1589642?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1589642, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1589642?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1589642?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1589642?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1589642?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1630516?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1630516. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1630516."
    },
    {
        "instruction": "In which chromosome is SNV1630516 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1630516?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1630516, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1630516?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1630516?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1630516?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1630516?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1543751?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1543751. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1543751."
    },
    {
        "instruction": "In which chromosome is SNV1543751 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1543751?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1543751, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1543751?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1543751?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1543751?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1543751?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1632446?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1632446. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1632446."
    },
    {
        "instruction": "In which chromosome is SNV1632446 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1632446?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1632446, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1632446?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1632446?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1632446?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1632446?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1633100?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1633100. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1633100."
    },
    {
        "instruction": "In which chromosome is SNV1633100 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1633100?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1633100, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1633100?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1633100?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1633100?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1633100?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1612250?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1612250. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1612250."
    },
    {
        "instruction": "In which chromosome is DEL1612250 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1612250?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1612250, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1612250?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1612250?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1612250?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1612250?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1660715?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1660715. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1660715."
    },
    {
        "instruction": "In which chromosome is DEL1660715 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1660715?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1660715, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1660715?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1660715?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1660715?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1660715?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1537390?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1537390. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1537390."
    },
    {
        "instruction": "In which chromosome is SNV1537390 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1537390?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1537390, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1537390?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1537390?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1537390?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1537390?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1587361?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1587361. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1587361."
    },
    {
        "instruction": "In which chromosome is SNV1587361 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1587361?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1587361, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1587361?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1587361?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1587361?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1587361?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1550472?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1550472. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1550472."
    },
    {
        "instruction": "In which chromosome is DEL1550472 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1550472?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1550472, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1550472?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1550472?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1550472?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1550472?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1564275?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1564275. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1564275."
    },
    {
        "instruction": "In which chromosome is SNV1564275 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1564275?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1564275, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1564275?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1564275?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1564275?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1564275?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1524634?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1524634. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1524634."
    },
    {
        "instruction": "In which chromosome is SNV1524634 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1524634?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1524634, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1524634?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1524634?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1524634?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1524634?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1644741?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1644741. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1644741."
    },
    {
        "instruction": "In which chromosome is SNV1644741 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1644741?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1644741, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1644741?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1644741?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1644741?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1644741?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1661007?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1661007. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1661007."
    },
    {
        "instruction": "In which chromosome is SNV1661007 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1661007?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1661007, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1661007?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1661007?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1661007?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1661007?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1585418?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1585418. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1585418."
    },
    {
        "instruction": "In which chromosome is SNV1585418 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1585418?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1585418, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1585418?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1585418?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1585418?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1585418?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1534011?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1534011. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1534011."
    },
    {
        "instruction": "In which chromosome is SNV1534011 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1534011?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1534011, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1534011?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1534011?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1534011?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1534011?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1599959?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1599959. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1599959."
    },
    {
        "instruction": "In which chromosome is SNV1599959 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1599959?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1599959, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1599959?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1599959?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1599959?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1599959?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1639171?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1639171. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1639171."
    },
    {
        "instruction": "In which chromosome is SNV1639171 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1639171?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1639171, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1639171?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1639171?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1639171?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1639171?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1519957?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1519957. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1519957."
    },
    {
        "instruction": "In which chromosome is SNV1519957 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1519957?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1519957, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1519957?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1519957?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1519957?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1519957?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1545020?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1545020. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1545020."
    },
    {
        "instruction": "In which chromosome is DEL1545020 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1545020?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1545020, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DEL1545020?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1545020?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1545020?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1545020?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1613195?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1613195. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1613195."
    },
    {
        "instruction": "In which chromosome is SNV1613195 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1613195?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1613195, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1613195?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1613195?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1613195?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1613195?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1664321?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1664321. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1664321."
    },
    {
        "instruction": "In which chromosome is SNV1664321 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1664321?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1664321, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1664321?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1664321?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1664321?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1664321?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1609249?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1609249. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1609249."
    },
    {
        "instruction": "In which chromosome is SNV1609249 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1609249?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1609249, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1609249?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1609249?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1609249?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1609249?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1640310?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1640310. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1640310."
    },
    {
        "instruction": "In which chromosome is SNV1640310 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1640310?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1640310, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1640310?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1640310?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1640310?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1640310?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1625398?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1625398. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1625398."
    },
    {
        "instruction": "In which chromosome is SNV1625398 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1625398?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1625398, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1625398?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1625398?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1625398?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1625398?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1597886?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1597886. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1597886."
    },
    {
        "instruction": "In which chromosome is SNV1597886 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1597886?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1597886, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1597886?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1597886?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1597886?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1597886?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1637541?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1637541. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1637541."
    },
    {
        "instruction": "In which chromosome is SNV1637541 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1637541?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1637541, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1637541?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1637541?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1637541?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1637541?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1631523?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1631523. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1631523."
    },
    {
        "instruction": "In which chromosome is SNV1631523 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1631523?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1631523, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1631523?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1631523?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1631523?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1631523?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1609968?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1609968. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1609968."
    },
    {
        "instruction": "In which chromosome is SNV1609968 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1609968?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1609968, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1609968?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1609968?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1609968?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1609968?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1523171?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1523171. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1523171."
    },
    {
        "instruction": "In which chromosome is SNV1523171 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1523171?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1523171, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1523171?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1523171?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1523171?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1523171?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1559019?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1559019. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1559019."
    },
    {
        "instruction": "In which chromosome is SNV1559019 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1559019?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1559019, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1559019?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1559019?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1559019?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1559019?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1628425?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1628425. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1628425."
    },
    {
        "instruction": "In which chromosome is DEL1628425 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1628425?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1628425, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1628425?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1628425?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1628425?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1628425?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1544031?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1544031. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1544031."
    },
    {
        "instruction": "In which chromosome is SNV1544031 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1544031?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1544031, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1544031?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1544031?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1544031?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1544031?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1557812?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1557812. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1557812."
    },
    {
        "instruction": "In which chromosome is SNV1557812 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1557812?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1557812, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1557812?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1557812?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1557812?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1557812?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1623050?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1623050. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1623050."
    },
    {
        "instruction": "In which chromosome is SNV1623050 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1623050?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1623050, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1623050?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1623050?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1623050?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1623050?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1661653?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1661653. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1661653."
    },
    {
        "instruction": "In which chromosome is SNV1661653 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1661653?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1661653, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1661653?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1661653?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1661653?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1661653?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1536571?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1536571. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1536571."
    },
    {
        "instruction": "In which chromosome is SNV1536571 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1536571?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1536571, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1536571?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1536571?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1536571?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1536571?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1645770?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1645770. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1645770."
    },
    {
        "instruction": "In which chromosome is SNV1645770 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1645770?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1645770, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1645770?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1645770?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1645770?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1645770?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1645832?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1645832. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1645832."
    },
    {
        "instruction": "In which chromosome is SNV1645832 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1645832?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1645832, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1645832?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1645832?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1645832?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1645832?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1594257?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1594257. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1594257."
    },
    {
        "instruction": "In which chromosome is SNV1594257 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1594257?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1594257, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1594257?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1594257?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1594257?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1594257?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with 1630028?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1630028. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1630028."
    },
    {
        "instruction": "In which chromosome is 1630028 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1630028?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1630028, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for 1630028?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for 1630028?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1630028?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1630028?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1574531?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1574531. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1574531."
    },
    {
        "instruction": "In which chromosome is SNV1574531 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1574531?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1574531, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1574531?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1574531?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1574531?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1574531?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1543016?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1543016. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1543016."
    },
    {
        "instruction": "In which chromosome is DEL1543016 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1543016?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1543016, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1543016?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1543016?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1543016?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1543016?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1543098?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1543098. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1543098."
    },
    {
        "instruction": "In which chromosome is SNV1543098 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1543098?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1543098, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1543098?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1543098?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1543098?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1543098?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1606121?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1606121. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1606121."
    },
    {
        "instruction": "In which chromosome is SNV1606121 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1606121?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1606121, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1606121?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1606121?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1606121?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1606121?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1524761?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1524761. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1524761."
    },
    {
        "instruction": "In which chromosome is SNV1524761 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1524761?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1524761, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1524761?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1524761?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1524761?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1524761?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1628244?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1628244. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1628244."
    },
    {
        "instruction": "In which chromosome is SNV1628244 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1628244?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1628244, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1628244?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1628244?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1628244?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1628244?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1590032?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1590032. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1590032."
    },
    {
        "instruction": "In which chromosome is SNV1590032 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1590032?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1590032, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1590032?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1590032?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1590032?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1590032?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1586599?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1586599. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1586599."
    },
    {
        "instruction": "In which chromosome is DUP1586599 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1586599?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1586599, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DUP1586599?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1586599?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1586599?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1586599?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1626636?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1626636. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1626636."
    },
    {
        "instruction": "In which chromosome is SNV1626636 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1626636?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1626636, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1626636?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1626636?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1626636?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1626636?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1622313?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1622313. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1622313."
    },
    {
        "instruction": "In which chromosome is SNV1622313 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1622313?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1622313, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1622313?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1622313?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1622313?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1622313?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1619718?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1619718. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1619718."
    },
    {
        "instruction": "In which chromosome is SNV1619718 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1619718?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1619718, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1619718?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1619718?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1619718?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1619718?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1554326?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1554326. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1554326."
    },
    {
        "instruction": "In which chromosome is SNV1554326 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1554326?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1554326, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1554326?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1554326?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1554326?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1554326?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1561668?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1561668. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1561668."
    },
    {
        "instruction": "In which chromosome is SNV1561668 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1561668?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1561668, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1561668?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1561668?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1561668?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1561668?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1561779?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1561779. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1561779."
    },
    {
        "instruction": "In which chromosome is SNV1561779 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1561779?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1561779, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1561779?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1561779?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1561779?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1561779?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1542494?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1542494. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1542494."
    },
    {
        "instruction": "In which chromosome is SNV1542494 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1542494?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1542494, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1542494?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1542494?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1542494?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1542494?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1520444?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1520444. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1520444."
    },
    {
        "instruction": "In which chromosome is SNV1520444 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1520444?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1520444, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1520444?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1520444?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1520444?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1520444?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1552942?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1552942. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1552942."
    },
    {
        "instruction": "In which chromosome is SNV1552942 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1552942?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1552942, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1552942?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1552942?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1552942?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1552942?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1575977?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1575977. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1575977."
    },
    {
        "instruction": "In which chromosome is SNV1575977 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1575977?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1575977, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1575977?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1575977?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1575977?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1575977?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1603009?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1603009. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1603009."
    },
    {
        "instruction": "In which chromosome is SNV1603009 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1603009?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1603009, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1603009?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1603009?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1603009?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1603009?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1636863?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1636863. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1636863."
    },
    {
        "instruction": "In which chromosome is SNV1636863 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1636863?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1636863, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1636863?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1636863?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1636863?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1636863?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1521803?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1521803. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1521803."
    },
    {
        "instruction": "In which chromosome is SNV1521803 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1521803?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1521803, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1521803?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1521803?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1521803?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1521803?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1588366?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1588366. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1588366."
    },
    {
        "instruction": "In which chromosome is SNV1588366 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1588366?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1588366, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1588366?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1588366?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1588366?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1588366?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1563536?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1563536. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1563536."
    },
    {
        "instruction": "In which chromosome is SNV1563536 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1563536?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1563536, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1563536?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1563536?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1563536?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1563536?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1563583?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1563583. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1563583."
    },
    {
        "instruction": "In which chromosome is SNV1563583 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1563583?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1563583, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1563583?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1563583?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1563583?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1563583?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1616755?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1616755. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1616755."
    },
    {
        "instruction": "In which chromosome is SNV1616755 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1616755?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1616755, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1616755?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1616755?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1616755?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1616755?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1655634?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1655634. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1655634."
    },
    {
        "instruction": "In which chromosome is SNV1655634 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1655634?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1655634, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1655634?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1655634?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1655634?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1655634?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1567983?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1567983. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1567983."
    },
    {
        "instruction": "In which chromosome is SNV1567983 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1567983?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1567983, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1567983?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1567983?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1567983?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1567983?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1621418?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1621418. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1621418."
    },
    {
        "instruction": "In which chromosome is SNV1621418 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1621418?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1621418, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1621418?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1621418?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1621418?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1621418?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1590250?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1590250. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1590250."
    },
    {
        "instruction": "In which chromosome is SNV1590250 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1590250?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1590250, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1590250?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1590250?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1590250?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1590250?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1646290?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1646290. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1646290."
    },
    {
        "instruction": "In which chromosome is SNV1646290 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1646290?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1646290, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1646290?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1646290?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1646290?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1646290?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1620270?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1620270. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1620270."
    },
    {
        "instruction": "In which chromosome is SNV1620270 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1620270?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1620270, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1620270?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1620270?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1620270?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1620270?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1620326?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1620326. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1620326."
    },
    {
        "instruction": "In which chromosome is SNV1620326 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1620326?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1620326, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1620326?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1620326?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1620326?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1620326?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with 1588912?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1588912. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1588912."
    },
    {
        "instruction": "In which chromosome is 1588912 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1588912?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1588912, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for 1588912?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for 1588912?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1588912?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1588912?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1589158?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1589158. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1589158."
    },
    {
        "instruction": "In which chromosome is SNV1589158 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1589158?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1589158, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1589158?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1589158?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1589158?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1589158?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1589160?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1589160. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1589160."
    },
    {
        "instruction": "In which chromosome is SNV1589160 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1589160?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1589160, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1589160?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1589160?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1589160?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1589160?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1608227?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1608227. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1608227."
    },
    {
        "instruction": "In which chromosome is DEL1608227 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1608227?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1608227, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1608227?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1608227?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1608227?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1608227?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1608608?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1608608. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1608608."
    },
    {
        "instruction": "In which chromosome is SNV1608608 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1608608?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1608608, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1608608?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1608608?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1608608?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1608608?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1655026?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1655026. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1655026."
    },
    {
        "instruction": "In which chromosome is SNV1655026 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1655026?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1655026, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1655026?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1655026?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1655026?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1655026?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1591763?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1591763. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1591763."
    },
    {
        "instruction": "In which chromosome is SNV1591763 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1591763?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1591763, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1591763?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1591763?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1591763?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1591763?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1591820?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1591820. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1591820."
    },
    {
        "instruction": "In which chromosome is SNV1591820 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1591820?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1591820, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1591820?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1591820?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1591820?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1591820?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1573505?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1573505. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1573505."
    },
    {
        "instruction": "In which chromosome is SNV1573505 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1573505?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1573505, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1573505?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1573505?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1573505?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1573505?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1637058?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1637058. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1637058."
    },
    {
        "instruction": "In which chromosome is DEL1637058 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1637058?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1637058, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1637058?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1637058?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1637058?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1637058?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1646271?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1646271. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1646271."
    },
    {
        "instruction": "In which chromosome is SNV1646271 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1646271?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1646271, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1646271?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1646271?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1646271?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1646271?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1621309?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1621309. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1621309."
    },
    {
        "instruction": "In which chromosome is SNV1621309 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1621309?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1621309, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1621309?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1621309?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1621309?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1621309?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1634345?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1634345. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1634345."
    },
    {
        "instruction": "In which chromosome is SNV1634345 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1634345?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1634345, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1634345?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1634345?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1634345?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1634345?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1625143?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1625143. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1625143."
    },
    {
        "instruction": "In which chromosome is SNV1625143 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1625143?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1625143, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1625143?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1625143?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1625143?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1625143?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1559487?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1559487. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1559487."
    },
    {
        "instruction": "In which chromosome is SNV1559487 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1559487?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1559487, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1559487?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1559487?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1559487?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1559487?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1779497?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1779497. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1779497."
    },
    {
        "instruction": "In which chromosome is SNV1779497 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1779497?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1779497, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1779497?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1779497?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1779497?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1779497?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1779820?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1779820. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1779820."
    },
    {
        "instruction": "In which chromosome is SNV1779820 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1779820?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1779820, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1779820?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1779820?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1779820?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1779820?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1776996?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1776996. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1776996."
    },
    {
        "instruction": "In which chromosome is SNV1776996 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1776996?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1776996, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1776996?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1776996?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1776996?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1776996?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1771225?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1771225. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1771225."
    },
    {
        "instruction": "In which chromosome is SNV1771225 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1771225?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1771225, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1771225?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1771225?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1771225?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1771225?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1776494?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1776494. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1776494."
    },
    {
        "instruction": "In which chromosome is SNV1776494 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1776494?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1776494, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1776494?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1776494?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1776494?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1776494?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1467492987 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1467492987 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1467492987 SNP."
    },
    {
        "instruction": "In which chromosome is RS1467492987 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1467492987 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1467492987 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1467492987 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1467492987 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1467492987 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1467492987 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1774769?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1774769. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1774769."
    },
    {
        "instruction": "In which chromosome is SNV1774769 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1774769?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1774769, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1774769?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1774769?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1774769?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1774769?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1774846?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1774846. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1774846."
    },
    {
        "instruction": "In which chromosome is SNV1774846 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1774846?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1774846, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1774846?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1774846?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1774846?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1774846?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1772762?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1772762. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1772762."
    },
    {
        "instruction": "In which chromosome is SNV1772762 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1772762?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1772762, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1772762?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1772762?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1772762?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1772762?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1776231?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1776231. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1776231."
    },
    {
        "instruction": "In which chromosome is SNV1776231 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1776231?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1776231, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1776231?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1776231?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1776231?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1776231?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1776348?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1776348. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1776348."
    },
    {
        "instruction": "In which chromosome is SNV1776348 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1776348?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1776348, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1776348?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1776348?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1776348?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1776348?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1774522?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1774522. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1774522."
    },
    {
        "instruction": "In which chromosome is SNV1774522 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1774522?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1774522, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1774522?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1774522?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1774522?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1774522?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1772955?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1772955. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1772955."
    },
    {
        "instruction": "In which chromosome is SNV1772955 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1772955?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1772955, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1772955?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1772955?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1772955?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1772955?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1772168?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1772168. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1772168."
    },
    {
        "instruction": "In which chromosome is SNV1772168 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1772168?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1772168, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1772168?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1772168?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1772168?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1772168?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1773929?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1773929. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1773929."
    },
    {
        "instruction": "In which chromosome is SNV1773929 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1773929?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1773929, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1773929?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1773929?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1773929?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1773929?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1772961?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1772961. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1772961."
    },
    {
        "instruction": "In which chromosome is SNV1772961 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1772961?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1772961, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1772961?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1772961?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1772961?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1772961?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778871 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778871 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778871 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778871 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778871 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778871 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778871 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778871 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778871 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778871 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS756860689 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS756860689 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS756860689 SNP."
    },
    {
        "instruction": "In which chromosome is RS756860689 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS756860689 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS756860689 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS756860689 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS756860689 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS756860689 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS756860689 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1208736713 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1208736713 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1208736713 SNP."
    },
    {
        "instruction": "In which chromosome is RS1208736713 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1208736713 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1208736713 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1208736713 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1208736713 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1208736713 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1208736713 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1330924197 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1330924197 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1330924197 SNP."
    },
    {
        "instruction": "In which chromosome is RS1330924197 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1330924197 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1330924197 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1330924197 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1330924197 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1330924197 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1330924197 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1297277579 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1297277579 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1297277579 SNP."
    },
    {
        "instruction": "In which chromosome is RS1297277579 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1297277579 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1297277579 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1297277579 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1297277579 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1297277579 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1297277579 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778823 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778823 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778823 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778823 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778823 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778823 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS1060503089 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503089 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503089 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503089 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503089 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503089 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503089 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503089 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503089 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503089 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503075 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503075 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503075 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503075 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503075 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503075 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503075 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503075 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503075 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503075 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DUP462855?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP462855. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP462855."
    },
    {
        "instruction": "In which chromosome is DUP462855 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP462855?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP462855, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP462855?",
        "output": "The variation length is 26018 base pairs."
    },
    {
        "instruction": "What is the origin for DUP462855?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP462855?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with RS1555284919 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555284919 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555284919 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555284919 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555284919 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555284919 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555284919 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555284919 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555284919 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555284919 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL527722?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL527722. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL527722."
    },
    {
        "instruction": "In which chromosome is DEL527722 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL527722?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL527722, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL527722?",
        "output": "The variation length is 383 base pairs."
    },
    {
        "instruction": "What is the origin for DEL527722?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL527722?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL565827?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL565827. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL565827."
    },
    {
        "instruction": "In which chromosome is DEL565827 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL565827?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL565827, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL565827?",
        "output": "The variation length is 724 base pairs."
    },
    {
        "instruction": "What is the origin for DEL565827?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL565827?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1593446608 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593446608 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593446608 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593446608 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593446608 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593446608 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593446608 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593446608 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593446608 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593446608 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL652797?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL652797. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL652797."
    },
    {
        "instruction": "In which chromosome is DEL652797 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL652797?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL652797, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL652797?",
        "output": "The variation length is 3187 base pairs."
    },
    {
        "instruction": "What is the origin for DEL652797?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL652797?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL652793?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL652793. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL652793."
    },
    {
        "instruction": "In which chromosome is DEL652793 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL652793?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL652793, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL652793?",
        "output": "The variation length is 8608 base pairs."
    },
    {
        "instruction": "What is the origin for DEL652793?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL652793?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820576?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820576. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820576."
    },
    {
        "instruction": "In which chromosome is DEL820576 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820576?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820576, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820576?",
        "output": "The variation length is 2621 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820576?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820576?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820577?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820577. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820577."
    },
    {
        "instruction": "In which chromosome is DEL820577 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820577?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820577, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820577?",
        "output": "The variation length is 26026 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820577?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820577?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820578?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820578. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820578."
    },
    {
        "instruction": "In which chromosome is DEL820578 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820578?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820578, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820578?",
        "output": "The variation length is 100498 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820578?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820578?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1949434078 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949434078 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949434078 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949434078 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949434078 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949434078 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949434078 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949434078 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949434078 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949434078 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952053594 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952053594 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952053594 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952053594 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952053594 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952053594 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952053594 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952053594 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952053594 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952053594 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952052800 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952052800 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952052800 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952052800 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952052800 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952052800 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952052800 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952052800 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952052800 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952052800 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS1555285126 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555285126 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555285126 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555285126 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555285126 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555285126 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1555285126 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555285126 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555285126 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555285126 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952090656 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952090656 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952090656 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952090656 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952090656 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952090656 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952090656 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952090656 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952090656 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952090656 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539364 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539364 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539364 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539364 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539364 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539364 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593539364 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539364 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539364 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539364 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831856 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831856 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831856 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831856 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831856 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831856 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952831856 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831856 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831856 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831856 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506505 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506505 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506505 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506505 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506505 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506505 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506505 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506505 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506505 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506505 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566174092 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566174092 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566174092 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566174092 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566174092 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566174092 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566174092 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566174092 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566174092 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566174092 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952455387 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952455387 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952455387 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952455387 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952455387 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952455387 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952455387 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952455387 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952455387 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952455387 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690853 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690853 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690853 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690853 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690853 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690853 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690853 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690853 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690853 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690853 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948535194 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948535194 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948535194 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948535194 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948535194 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948535194 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948535194 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948535194 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948535194 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948535194 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP986512?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP986512. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP986512."
    },
    {
        "instruction": "In which chromosome is DUP986512 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP986512?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP986512, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP986512?",
        "output": "The variation length is 27093 base pairs."
    },
    {
        "instruction": "What is the origin for DUP986512?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP986512?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with RS1393042716 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1393042716 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1393042716 SNP."
    },
    {
        "instruction": "In which chromosome is RS1393042716 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1393042716 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1393042716 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1393042716 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1393042716 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1393042716 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1393042716 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952481610 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952481610 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952481610 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952481610 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952481610 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952481610 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952481610 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952481610 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952481610 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952481610 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS369755801 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS369755801 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS369755801 SNP."
    },
    {
        "instruction": "In which chromosome is RS369755801 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS369755801 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS369755801 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS369755801 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS369755801 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS369755801 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS369755801 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949338458 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949338458 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949338458 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949338458 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949338458 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949338458 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949338458 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949338458 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949338458 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949338458 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1251503080 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1251503080 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1251503080 SNP."
    },
    {
        "instruction": "In which chromosome is RS1251503080 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1251503080 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1251503080 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1251503080 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1251503080 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1251503080 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1251503080 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593547157 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593547157 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593547157 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593547157 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593547157 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593547157 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593547157 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593547157 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593547157 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593547157 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952089702 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952089702 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952089702 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952089702 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952089702 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952089702 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952089702 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952089702 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952089702 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952089702 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1426744051 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1426744051 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1426744051 SNP."
    },
    {
        "instruction": "In which chromosome is RS1426744051 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1426744051 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1426744051 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1426744051 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1426744051 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1426744051 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1426744051 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412219 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412219 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412219 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412219 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412219 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412219 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412219 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412219 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412219 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412219 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS762271261 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762271261 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762271261 SNP."
    },
    {
        "instruction": "In which chromosome is RS762271261 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762271261 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762271261 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS762271261 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762271261 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762271261 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762271261 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048362?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048362. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048362."
    },
    {
        "instruction": "In which chromosome is SNV1048362 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048362?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048362, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048362?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048362?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048362?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048362?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048335?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048335. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048335."
    },
    {
        "instruction": "In which chromosome is SNV1048335 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048335?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048335, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048335?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048335?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048335?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048335?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1039172?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1039172. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1039172."
    },
    {
        "instruction": "In which chromosome is DUP1039172 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1039172?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1039172, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP1039172?",
        "output": "The variation length is 20422 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1039172?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1039172?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DEL1054555?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1054555. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1054555."
    },
    {
        "instruction": "In which chromosome is DEL1054555 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1054555?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1054555, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1054555?",
        "output": "The variation length is 1862 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1054555?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1054555?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1062979?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1062979. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1062979."
    },
    {
        "instruction": "In which chromosome is DEL1062979 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1062979?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1062979, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1062979?",
        "output": "The variation length is 38 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1062979?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1062979?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1062979?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1057632?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1057632. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1057632."
    },
    {
        "instruction": "In which chromosome is DEL1057632 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1057632?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1057632, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1057632?",
        "output": "The variation length is 4830 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1057632?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1057632?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DUP1057634?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1057634. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1057634."
    },
    {
        "instruction": "In which chromosome is DUP1057634 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1057634?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1057634, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1057634?",
        "output": "The variation length is 53788 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1057634?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1057634?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DUP1057631?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1057631. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1057631."
    },
    {
        "instruction": "In which chromosome is DUP1057631 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1057631?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1057631, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1057631?",
        "output": "The variation length is 74184 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1057631?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1057631?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DEL1057628?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1057628. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1057628."
    },
    {
        "instruction": "In which chromosome is DEL1057628 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1057628?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1057628, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1057628?",
        "output": "The variation length is 327235 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1057628?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1057628?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1063002?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1063002. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1063002."
    },
    {
        "instruction": "In which chromosome is DEL1063002 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1063002?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1063002, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1063002?",
        "output": "The variation length is 25 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1063002?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1063002?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1080087?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080087. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080087."
    },
    {
        "instruction": "In which chromosome is SNV1080087 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080087?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080087, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080087?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080087?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080087?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080087?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101894?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101894. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101894."
    },
    {
        "instruction": "In which chromosome is SNV1101894 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101894?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101894, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101894?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101894?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101894?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101894?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101891?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101891. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101891."
    },
    {
        "instruction": "In which chromosome is SNV1101891 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101891?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101891, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101891?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101891?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101891?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101891?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1101899?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1101899. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1101899."
    },
    {
        "instruction": "In which chromosome is DEL1101899 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1101899?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1101899, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1101899?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1101899?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1101899?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1101899?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101889?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101889. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101889."
    },
    {
        "instruction": "In which chromosome is SNV1101889 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101889?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101889, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101889?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101889?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101889?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101889?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123350?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123350. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123350."
    },
    {
        "instruction": "In which chromosome is SNV1123350 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123350?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123350, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123350?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123350?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123350?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123350?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123358?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123358. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123358."
    },
    {
        "instruction": "In which chromosome is SNV1123358 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123358?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123358, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123358?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123358?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123358?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123358?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123347?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123347. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123347."
    },
    {
        "instruction": "In which chromosome is SNV1123347 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123347?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123347, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123347?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123347?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123347?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123347?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1144229?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1144229. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1144229."
    },
    {
        "instruction": "In which chromosome is SNV1144229 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1144229?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1144229, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1144229?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1144229?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1144229?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1144229?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1144227?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1144227. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1144227."
    },
    {
        "instruction": "In which chromosome is DUP1144227 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1144227?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1144227, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DUP1144227?",
        "output": "The variation length is 5 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1144227?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1144227?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1144227?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1467413?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1467413. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1467413."
    },
    {
        "instruction": "In which chromosome is SNV1467413 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1467413?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1467413, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1467413?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1467413?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1467413?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1467413?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1440146?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1440146. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1440146."
    },
    {
        "instruction": "In which chromosome is DEL1440146 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1440146?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1440146, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1440146?",
        "output": "The variation length is 98 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1440146?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1440146?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1470841?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1470841. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1470841."
    },
    {
        "instruction": "In which chromosome is SNV1470841 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1470841?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1470841, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1470841?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1470841?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1470841?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1470841?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1402255?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1402255. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1402255."
    },
    {
        "instruction": "In which chromosome is DEL1402255 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1402255?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1402255, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1402255?",
        "output": "The variation length is 27093 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1402255?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1402255?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1435992?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1435992. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1435992."
    },
    {
        "instruction": "In which chromosome is SNV1435992 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1435992?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1435992, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1435992?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1435992?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1435992?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1435992?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1347664?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1347664. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1347664."
    },
    {
        "instruction": "In which chromosome is SNV1347664 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1347664?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1347664, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1347664?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1347664?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1347664?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1347664?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1346664?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1346664. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1346664."
    },
    {
        "instruction": "In which chromosome is SNV1346664 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1346664?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1346664, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1346664?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1346664?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1346664?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1346664?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1432827?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1432827. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1432827."
    },
    {
        "instruction": "In which chromosome is SNV1432827 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1432827?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1432827, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1432827?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1432827?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1432827?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1432827?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1362284?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1362284. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1362284."
    },
    {
        "instruction": "In which chromosome is SNV1362284 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1362284?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1362284, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1362284?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1362284?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1362284?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1362284?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1398013?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1398013. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1398013."
    },
    {
        "instruction": "In which chromosome is SNV1398013 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1398013?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1398013, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1398013?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1398013?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1398013?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1398013?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1458168?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1458168. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1458168."
    },
    {
        "instruction": "In which chromosome is SNV1458168 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1458168?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1458168, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1458168?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1458168?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1458168?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1458168?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1503868?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1503868. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1503868."
    },
    {
        "instruction": "In which chromosome is SNV1503868 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1503868?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1503868, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1503868?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1503868?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1503868?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1503868?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1406141?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1406141. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1406141."
    },
    {
        "instruction": "In which chromosome is DEL1406141 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1406141?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1406141, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1406141?",
        "output": "The variation length is 266313 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1406141?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1406141?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1419975?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1419975. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1419975."
    },
    {
        "instruction": "In which chromosome is SNV1419975 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1419975?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1419975, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1419975?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1419975?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1419975?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1419975?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1503515?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1503515. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1503515."
    },
    {
        "instruction": "In which chromosome is SNV1503515 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1503515?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1503515, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1503515?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1503515?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1503515?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1503515?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1507734?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1507734. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1507734."
    },
    {
        "instruction": "In which chromosome is SNV1507734 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1507734?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1507734, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1507734?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1507734?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1507734?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1507734?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1515733?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1515733. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1515733."
    },
    {
        "instruction": "In which chromosome is SNV1515733 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1515733?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1515733, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1515733?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1515733?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1515733?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1515733?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1428982?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1428982. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1428982."
    },
    {
        "instruction": "In which chromosome is SNV1428982 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1428982?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1428982, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1428982?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1428982?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1428982?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1428982?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1348014?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1348014. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1348014."
    },
    {
        "instruction": "In which chromosome is SNV1348014 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1348014?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1348014, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1348014?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1348014?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1348014?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1348014?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1436648?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1436648. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1436648."
    },
    {
        "instruction": "In which chromosome is SNV1436648 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1436648?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1436648, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1436648?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1436648?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1436648?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1436648?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1488722?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1488722. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1488722."
    },
    {
        "instruction": "In which chromosome is SNV1488722 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1488722?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1488722, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1488722?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1488722?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1488722?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1488722?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1488619?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1488619. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1488619."
    },
    {
        "instruction": "In which chromosome is SNV1488619 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1488619?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1488619, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1488619?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1488619?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1488619?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1488619?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1515987?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1515987. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1515987."
    },
    {
        "instruction": "In which chromosome is SNV1515987 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1515987?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1515987, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1515987?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1515987?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1515987?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1515987?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1389387?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1389387. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1389387."
    },
    {
        "instruction": "In which chromosome is SNV1389387 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1389387?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1389387, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1389387?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1389387?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1389387?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1389387?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 1417100?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1417100. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1417100."
    },
    {
        "instruction": "In which chromosome is 1417100 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1417100?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1417100, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for 1417100?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for 1417100?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1417100?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1417100?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1363050?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1363050. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1363050."
    },
    {
        "instruction": "In which chromosome is SNV1363050 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1363050?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1363050, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1363050?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1363050?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1363050?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1363050?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1372693?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1372693. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1372693."
    },
    {
        "instruction": "In which chromosome is SNV1372693 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1372693?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1372693, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1372693?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1372693?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1372693?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1372693?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1455281?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1455281. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1455281."
    },
    {
        "instruction": "In which chromosome is SNV1455281 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1455281?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1455281, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1455281?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1455281?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1455281?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1455281?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1638739?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1638739. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1638739."
    },
    {
        "instruction": "In which chromosome is SNV1638739 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1638739?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1638739, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1638739?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1638739?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1638739?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1638739?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1614637?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1614637. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1614637."
    },
    {
        "instruction": "In which chromosome is SNV1614637 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1614637?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1614637, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1614637?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1614637?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1614637?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1614637?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1585095?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1585095. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1585095."
    },
    {
        "instruction": "In which chromosome is SNV1585095 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1585095?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1585095, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1585095?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1585095?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1585095?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1585095?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1613864?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1613864. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1613864."
    },
    {
        "instruction": "In which chromosome is SNV1613864 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1613864?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1613864, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1613864?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1613864?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1613864?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1613864?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1639795?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1639795. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1639795."
    },
    {
        "instruction": "In which chromosome is SNV1639795 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1639795?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1639795, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1639795?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1639795?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1639795?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1639795?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1600511?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1600511. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1600511."
    },
    {
        "instruction": "In which chromosome is SNV1600511 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1600511?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1600511, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1600511?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1600511?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1600511?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1600511?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1653931?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1653931. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1653931."
    },
    {
        "instruction": "In which chromosome is SNV1653931 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1653931?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1653931, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1653931?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1653931?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1653931?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1653931?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1615047?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1615047. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1615047."
    },
    {
        "instruction": "In which chromosome is SNV1615047 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1615047?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1615047, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1615047?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1615047?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1615047?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1615047?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1527833?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1527833. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1527833."
    },
    {
        "instruction": "In which chromosome is SNV1527833 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1527833?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1527833, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1527833?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1527833?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1527833?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1527833?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1527999?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1527999. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1527999."
    },
    {
        "instruction": "In which chromosome is SNV1527999 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1527999?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1527999, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1527999?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1527999?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1527999?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1527999?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1535265?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1535265. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1535265."
    },
    {
        "instruction": "In which chromosome is SNV1535265 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1535265?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1535265, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1535265?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1535265?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1535265?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1535265?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1533389?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1533389. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1533389."
    },
    {
        "instruction": "In which chromosome is SNV1533389 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1533389?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1533389, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1533389?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1533389?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1533389?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1533389?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1599287?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1599287. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1599287."
    },
    {
        "instruction": "In which chromosome is SNV1599287 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1599287?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1599287, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1599287?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1599287?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1599287?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1599287?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1566986?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1566986. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1566986."
    },
    {
        "instruction": "In which chromosome is SNV1566986 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1566986?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1566986, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1566986?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1566986?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1566986?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1566986?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1640995?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1640995. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1640995."
    },
    {
        "instruction": "In which chromosome is SNV1640995 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1640995?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1640995, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1640995?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1640995?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1640995?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1640995?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1553853?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1553853. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1553853."
    },
    {
        "instruction": "In which chromosome is SNV1553853 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1553853?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1553853, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1553853?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1553853?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1553853?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1553853?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1554044?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1554044. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1554044."
    },
    {
        "instruction": "In which chromosome is SNV1554044 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1554044?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1554044, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1554044?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1554044?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1554044?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1554044?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1607394?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1607394. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1607394."
    },
    {
        "instruction": "In which chromosome is SNV1607394 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1607394?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1607394, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1607394?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1607394?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1607394?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1607394?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1615544?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1615544. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1615544."
    },
    {
        "instruction": "In which chromosome is SNV1615544 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1615544?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1615544, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1615544?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1615544?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1615544?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1615544?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1541823?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1541823. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1541823."
    },
    {
        "instruction": "In which chromosome is SNV1541823 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1541823?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1541823, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1541823?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1541823?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1541823?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1541823?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1605824?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1605824. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1605824."
    },
    {
        "instruction": "In which chromosome is SNV1605824 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1605824?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1605824, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1605824?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1605824?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1605824?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1605824?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1555317?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1555317. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1555317."
    },
    {
        "instruction": "In which chromosome is SNV1555317 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1555317?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1555317, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1555317?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1555317?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1555317?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1555317?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1540461?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1540461. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1540461."
    },
    {
        "instruction": "In which chromosome is SNV1540461 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1540461?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1540461, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1540461?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1540461?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1540461?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1540461?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1607531?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1607531. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1607531."
    },
    {
        "instruction": "In which chromosome is SNV1607531 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1607531?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1607531, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1607531?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1607531?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1607531?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1607531?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1655353?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1655353. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1655353."
    },
    {
        "instruction": "In which chromosome is SNV1655353 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1655353?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1655353, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1655353?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1655353?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1655353?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1655353?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1568297?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1568297. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1568297."
    },
    {
        "instruction": "In which chromosome is SNV1568297 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1568297?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1568297, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1568297?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1568297?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1568297?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1568297?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1570867?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1570867. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1570867."
    },
    {
        "instruction": "In which chromosome is SNV1570867 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1570867?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1570867, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1570867?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1570867?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1570867?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1570867?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1607302?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1607302. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1607302."
    },
    {
        "instruction": "In which chromosome is SNV1607302 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1607302?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1607302, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1607302?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1607302?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1607302?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1607302?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1656368?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1656368. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1656368."
    },
    {
        "instruction": "In which chromosome is SNV1656368 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1656368?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1656368, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1656368?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1656368?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1656368?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1656368?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1656375?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1656375. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1656375."
    },
    {
        "instruction": "In which chromosome is SNV1656375 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1656375?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1656375, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1656375?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1656375?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1656375?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1656375?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1594648?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1594648. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1594648."
    },
    {
        "instruction": "In which chromosome is DEL1594648 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1594648?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1594648, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1594648?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1594648?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1594648?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1594648?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1627101?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1627101. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1627101."
    },
    {
        "instruction": "In which chromosome is SNV1627101 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1627101?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1627101, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1627101?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1627101?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1627101?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1627101?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1590704?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1590704. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1590704."
    },
    {
        "instruction": "In which chromosome is SNV1590704 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1590704?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1590704, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1590704?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1590704?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1590704?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1590704?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with 1590746?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1590746. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1590746."
    },
    {
        "instruction": "In which chromosome is 1590746 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1590746?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1590746, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for 1590746?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for 1590746?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1590746?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1590746?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1609485?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1609485. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1609485."
    },
    {
        "instruction": "In which chromosome is DEL1609485 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1609485?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1609485, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DEL1609485?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1609485?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1609485?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1609485?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1541920?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1541920. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1541920."
    },
    {
        "instruction": "In which chromosome is SNV1541920 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1541920?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1541920, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1541920?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1541920?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1541920?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1541920?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1664864?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1664864. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1664864."
    },
    {
        "instruction": "In which chromosome is SNV1664864 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1664864?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1664864, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1664864?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1664864?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1664864?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1664864?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1532280?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1532280. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1532280."
    },
    {
        "instruction": "In which chromosome is SNV1532280 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1532280?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1532280, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1532280?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1532280?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1532280?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1532280?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1631117?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1631117. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1631117."
    },
    {
        "instruction": "In which chromosome is SNV1631117 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1631117?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1631117, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1631117?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1631117?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1631117?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1631117?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1571046?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1571046. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1571046."
    },
    {
        "instruction": "In which chromosome is SNV1571046 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1571046?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1571046, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1571046?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1571046?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1571046?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1571046?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1630744?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1630744. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1630744."
    },
    {
        "instruction": "In which chromosome is SNV1630744 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1630744?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1630744, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1630744?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1630744?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1630744?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1630744?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1546407?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1546407. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1546407."
    },
    {
        "instruction": "In which chromosome is DUP1546407 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1546407?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1546407, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DUP1546407?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1546407?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1546407?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1546407?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1660964?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1660964. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1660964."
    },
    {
        "instruction": "In which chromosome is DEL1660964 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1660964?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1660964, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1660964?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1660964?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1660964?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1660964?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1609676?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1609676. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1609676."
    },
    {
        "instruction": "In which chromosome is SNV1609676 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1609676?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1609676, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1609676?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1609676?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1609676?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1609676?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1542873?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1542873. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1542873."
    },
    {
        "instruction": "In which chromosome is SNV1542873 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1542873?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1542873, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1542873?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1542873?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1542873?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1542873?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1560065?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1560065. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1560065."
    },
    {
        "instruction": "In which chromosome is SNV1560065 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1560065?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1560065, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1560065?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1560065?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1560065?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1560065?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1571207?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1571207. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1571207."
    },
    {
        "instruction": "In which chromosome is SNV1571207 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1571207?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1571207, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1571207?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1571207?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1571207?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1571207?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1522597?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1522597. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1522597."
    },
    {
        "instruction": "In which chromosome is SNV1522597 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1522597?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1522597, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1522597?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1522597?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1522597?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1522597?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1637623?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1637623. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1637623."
    },
    {
        "instruction": "In which chromosome is SNV1637623 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1637623?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1637623, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1637623?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1637623?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1637623?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1637623?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1539504?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1539504. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1539504."
    },
    {
        "instruction": "In which chromosome is SNV1539504 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1539504?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1539504, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1539504?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1539504?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1539504?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1539504?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1522523?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1522523. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1522523."
    },
    {
        "instruction": "In which chromosome is SNV1522523 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1522523?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1522523, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1522523?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1522523?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1522523?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1522523?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1611197?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1611197. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1611197."
    },
    {
        "instruction": "In which chromosome is SNV1611197 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1611197?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1611197, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1611197?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1611197?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1611197?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1611197?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1601836?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1601836. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1601836."
    },
    {
        "instruction": "In which chromosome is SNV1601836 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1601836?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1601836, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1601836?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1601836?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1601836?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1601836?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1550514?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1550514. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1550514."
    },
    {
        "instruction": "In which chromosome is SNV1550514 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1550514?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1550514, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1550514?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1550514?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1550514?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1550514?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1579253?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1579253. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1579253."
    },
    {
        "instruction": "In which chromosome is SNV1579253 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1579253?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1579253, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1579253?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1579253?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1579253?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1579253?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1579468?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1579468. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1579468."
    },
    {
        "instruction": "In which chromosome is SNV1579468 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1579468?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1579468, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1579468?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1579468?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1579468?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1579468?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1529170?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1529170. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1529170."
    },
    {
        "instruction": "In which chromosome is SNV1529170 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1529170?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1529170, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1529170?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1529170?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1529170?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1529170?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1560624?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1560624. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1560624."
    },
    {
        "instruction": "In which chromosome is SNV1560624 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1560624?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1560624, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1560624?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1560624?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1560624?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1560624?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1660055?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1660055. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1660055."
    },
    {
        "instruction": "In which chromosome is SNV1660055 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1660055?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1660055, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1660055?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1660055?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1660055?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1660055?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1628569?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1628569. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1628569."
    },
    {
        "instruction": "In which chromosome is SNV1628569 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1628569?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1628569, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1628569?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1628569?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1628569?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1628569?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1607776?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1607776. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1607776."
    },
    {
        "instruction": "In which chromosome is DUP1607776 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1607776?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1607776, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DUP1607776?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1607776?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1607776?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1607776?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1577057?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1577057. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1577057."
    },
    {
        "instruction": "In which chromosome is SNV1577057 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1577057?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1577057, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1577057?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1577057?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1577057?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1577057?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1530027?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1530027. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1530027."
    },
    {
        "instruction": "In which chromosome is SNV1530027 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1530027?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1530027, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1530027?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1530027?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1530027?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1530027?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1583892?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1583892. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1583892."
    },
    {
        "instruction": "In which chromosome is SNV1583892 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1583892?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1583892, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1583892?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1583892?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1583892?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1583892?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1646102?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1646102. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1646102."
    },
    {
        "instruction": "In which chromosome is SNV1646102 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1646102?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1646102, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1646102?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1646102?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1646102?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1646102?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1532549?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1532549. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1532549."
    },
    {
        "instruction": "In which chromosome is SNV1532549 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1532549?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1532549, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1532549?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1532549?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1532549?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1532549?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with INS1634367?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsINS1634367. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/INS1634367."
    },
    {
        "instruction": "In which chromosome is INS1634367 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the INS1634367?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of INS1634367, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for INS1634367?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for INS1634367?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for INS1634367?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for INS1634367?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1537030?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1537030. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1537030."
    },
    {
        "instruction": "In which chromosome is SNV1537030 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1537030?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1537030, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1537030?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1537030?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1537030?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1537030?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1537091?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1537091. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1537091."
    },
    {
        "instruction": "In which chromosome is SNV1537091 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1537091?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1537091, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1537091?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1537091?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1537091?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1537091?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1572164?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1572164. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1572164."
    },
    {
        "instruction": "In which chromosome is SNV1572164 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1572164?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1572164, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1572164?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1572164?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1572164?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1572164?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1625066?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1625066. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1625066."
    },
    {
        "instruction": "In which chromosome is SNV1625066 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1625066?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1625066, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1625066?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1625066?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1625066?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1625066?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1956449?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1956449. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1956449."
    },
    {
        "instruction": "In which chromosome is SNV1956449 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1956449?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1956449, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1956449?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1956449?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1956449?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1956449?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1959884?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1959884. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1959884."
    },
    {
        "instruction": "In which chromosome is SNV1959884 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1959884?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1959884, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1959884?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1959884?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1959884?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1959884?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1966144?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1966144. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1966144."
    },
    {
        "instruction": "In which chromosome is SNV1966144 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1966144?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1966144, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1966144?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1966144?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1966144?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1966144?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1967423?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1967423. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1967423."
    },
    {
        "instruction": "In which chromosome is SNV1967423 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1967423?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1967423, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1967423?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1967423?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1967423?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1967423?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1910597?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1910597. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1910597."
    },
    {
        "instruction": "In which chromosome is SNV1910597 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1910597?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1910597, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1910597?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1910597?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1910597?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1910597?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1907907?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1907907. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1907907."
    },
    {
        "instruction": "In which chromosome is SNV1907907 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1907907?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1907907, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1907907?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1907907?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1907907?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1907907?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1912808?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1912808. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1912808."
    },
    {
        "instruction": "In which chromosome is SNV1912808 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1912808?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1912808, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1912808?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1912808?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1912808?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1912808?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1916475?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1916475. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1916475."
    },
    {
        "instruction": "In which chromosome is SNV1916475 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1916475?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1916475, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1916475?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1916475?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1916475?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1916475?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1978695?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1978695. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1978695."
    },
    {
        "instruction": "In which chromosome is SNV1978695 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1978695?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1978695, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1978695?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1978695?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1978695?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1978695?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1968780?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1968780. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1968780."
    },
    {
        "instruction": "In which chromosome is SNV1968780 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1968780?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1968780, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1968780?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1968780?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1968780?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1968780?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1983005?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1983005. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1983005."
    },
    {
        "instruction": "In which chromosome is SNV1983005 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1983005?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1983005, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1983005?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1983005?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1983005?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1983005?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1920493?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1920493. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1920493."
    },
    {
        "instruction": "In which chromosome is SNV1920493 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1920493?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1920493, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1920493?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1920493?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1920493?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1920493?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1914545?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1914545. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1914545."
    },
    {
        "instruction": "In which chromosome is DEL1914545 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1914545?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1914545, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1914545?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1914545?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1914545?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1914545?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1922420?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1922420. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1922420."
    },
    {
        "instruction": "In which chromosome is SNV1922420 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1922420?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1922420, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1922420?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1922420?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1922420?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1922420?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1991164?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1991164. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1991164."
    },
    {
        "instruction": "In which chromosome is SNV1991164 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1991164?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1991164, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1991164?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1991164?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1991164?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1991164?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1913479?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1913479. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1913479."
    },
    {
        "instruction": "In which chromosome is SNV1913479 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1913479?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1913479, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1913479?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1913479?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1913479?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1913479?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1986823?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1986823. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1986823."
    },
    {
        "instruction": "In which chromosome is SNV1986823 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1986823?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1986823, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1986823?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1986823?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1986823?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1986823?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1910509?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1910509. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1910509."
    },
    {
        "instruction": "In which chromosome is SNV1910509 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1910509?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1910509, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1910509?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1910509?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1910509?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1910509?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1931935?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1931935. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1931935."
    },
    {
        "instruction": "In which chromosome is SNV1931935 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1931935?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1931935, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1931935?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1931935?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1931935?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1931935?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1930292?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1930292. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1930292."
    },
    {
        "instruction": "In which chromosome is SNV1930292 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1930292?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1930292, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1930292?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1930292?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1930292?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1930292?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1924707?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1924707. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1924707."
    },
    {
        "instruction": "In which chromosome is SNV1924707 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1924707?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1924707, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1924707?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1924707?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1924707?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1924707?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1983452?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1983452. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1983452."
    },
    {
        "instruction": "In which chromosome is SNV1983452 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1983452?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1983452, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1983452?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1983452?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1983452?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1983452?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1992670?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1992670. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1992670."
    },
    {
        "instruction": "In which chromosome is DEL1992670 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1992670?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1992670, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1992670?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1992670?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1992670?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1992670?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1913735?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1913735. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1913735."
    },
    {
        "instruction": "In which chromosome is SNV1913735 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1913735?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1913735, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1913735?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1913735?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1913735?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1913735?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1917592?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1917592. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1917592."
    },
    {
        "instruction": "In which chromosome is SNV1917592 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1917592?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1917592, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1917592?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1917592?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1917592?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1917592?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1923480?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1923480. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1923480."
    },
    {
        "instruction": "In which chromosome is SNV1923480 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1923480?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1923480, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1923480?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1923480?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1923480?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1923480?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1923799?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1923799. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1923799."
    },
    {
        "instruction": "In which chromosome is SNV1923799 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1923799?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1923799, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1923799?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1923799?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1923799?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1923799?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1985158?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1985158. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1985158."
    },
    {
        "instruction": "In which chromosome is SNV1985158 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1985158?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1985158, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1985158?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1985158?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1985158?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1985158?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1982229?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1982229. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1982229."
    },
    {
        "instruction": "In which chromosome is SNV1982229 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1982229?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1982229, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1982229?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1982229?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1982229?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1982229?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with IND1923226?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND1923226. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND1923226."
    },
    {
        "instruction": "In which chromosome is IND1923226 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND1923226?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of IND1923226, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for IND1923226?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for IND1923226?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND1923226?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for IND1923226?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1994494?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1994494. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1994494."
    },
    {
        "instruction": "In which chromosome is SNV1994494 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1994494?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1994494, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1994494?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1994494?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1994494?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1994494?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2001215?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2001215. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2001215."
    },
    {
        "instruction": "In which chromosome is SNV2001215 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2001215?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2001215, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2001215?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2001215?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2001215?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2001215?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2004913?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2004913. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2004913."
    },
    {
        "instruction": "In which chromosome is SNV2004913 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2004913?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2004913, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2004913?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2004913?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2004913?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2004913?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1923380?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1923380. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1923380."
    },
    {
        "instruction": "In which chromosome is SNV1923380 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1923380?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1923380, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1923380?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1923380?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1923380?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1923380?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1994288?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1994288. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1994288."
    },
    {
        "instruction": "In which chromosome is DEL1994288 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1994288?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1994288, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1994288?",
        "output": "The variation length is 9 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1994288?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1994288?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1994288?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV2002099?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2002099. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2002099."
    },
    {
        "instruction": "In which chromosome is SNV2002099 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2002099?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2002099, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2002099?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2002099?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2002099?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2002099?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1996293?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1996293. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1996293."
    },
    {
        "instruction": "In which chromosome is SNV1996293 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1996293?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1996293, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1996293?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1996293?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1996293?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1996293?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2001407?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2001407. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2001407."
    },
    {
        "instruction": "In which chromosome is SNV2001407 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2001407?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2001407, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2001407?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2001407?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2001407?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2001407?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2005806?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2005806. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2005806."
    },
    {
        "instruction": "In which chromosome is SNV2005806 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2005806?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2005806, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2005806?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2005806?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2005806?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2005806?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2011690?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2011690. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2011690."
    },
    {
        "instruction": "In which chromosome is SNV2011690 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2011690?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2011690, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2011690?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2011690?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2011690?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2011690?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2008337?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2008337. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2008337."
    },
    {
        "instruction": "In which chromosome is SNV2008337 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2008337?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2008337, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2008337?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2008337?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2008337?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2008337?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2015369?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2015369. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2015369."
    },
    {
        "instruction": "In which chromosome is SNV2015369 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2015369?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2015369, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV2015369?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2015369?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2015369?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2015369?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2008041?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2008041. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2008041."
    },
    {
        "instruction": "In which chromosome is SNV2008041 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2008041?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2008041, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2008041?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2008041?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2008041?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2008041?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2018589?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2018589. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2018589."
    },
    {
        "instruction": "In which chromosome is SNV2018589 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2018589?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2018589, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2018589?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2018589?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2018589?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2018589?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2017180?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2017180. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2017180."
    },
    {
        "instruction": "In which chromosome is SNV2017180 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2017180?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2017180, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2017180?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2017180?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2017180?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2017180?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2017238?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2017238. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2017238."
    },
    {
        "instruction": "In which chromosome is SNV2017238 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2017238?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2017238, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2017238?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2017238?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2017238?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2017238?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2023852?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2023852. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2023852."
    },
    {
        "instruction": "In which chromosome is SNV2023852 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2023852?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2023852, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2023852?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2023852?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2023852?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2023852?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2039096?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2039096. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2039096."
    },
    {
        "instruction": "In which chromosome is SNV2039096 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2039096?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2039096, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2039096?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2039096?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2039096?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2039096?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2059226?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2059226. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2059226."
    },
    {
        "instruction": "In which chromosome is SNV2059226 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2059226?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2059226, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2059226?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2059226?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2059226?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2059226?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2059245?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2059245. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2059245."
    },
    {
        "instruction": "In which chromosome is SNV2059245 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2059245?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2059245, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2059245?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2059245?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2059245?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2059245?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2061047?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2061047. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2061047."
    },
    {
        "instruction": "In which chromosome is SNV2061047 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2061047?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2061047, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2061047?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2061047?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2061047?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2061047?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2054653?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2054653. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2054653."
    },
    {
        "instruction": "In which chromosome is SNV2054653 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2054653?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2054653, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2054653?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2054653?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2054653?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2054653?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2047890?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2047890. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2047890."
    },
    {
        "instruction": "In which chromosome is SNV2047890 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2047890?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2047890, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2047890?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2047890?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2047890?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2047890?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2056641?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2056641. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2056641."
    },
    {
        "instruction": "In which chromosome is SNV2056641 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2056641?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2056641, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2056641?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2056641?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2056641?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2056641?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2053548?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2053548. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2053548."
    },
    {
        "instruction": "In which chromosome is SNV2053548 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2053548?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2053548, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2053548?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2053548?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2053548?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2053548?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2053587?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2053587. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2053587."
    },
    {
        "instruction": "In which chromosome is SNV2053587 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2053587?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2053587, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2053587?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2053587?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2053587?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2053587?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2050393?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2050393. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2050393."
    },
    {
        "instruction": "In which chromosome is SNV2050393 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2050393?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2050393, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2050393?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2050393?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2050393?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2050393?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2051754?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2051754. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2051754."
    },
    {
        "instruction": "In which chromosome is SNV2051754 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2051754?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2051754, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2051754?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2051754?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2051754?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2051754?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2069428?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2069428. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2069428."
    },
    {
        "instruction": "In which chromosome is SNV2069428 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2069428?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2069428, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV2069428?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2069428?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2069428?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2069428?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV2052632?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2052632. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2052632."
    },
    {
        "instruction": "In which chromosome is SNV2052632 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2052632?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2052632, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2052632?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2052632?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2052632?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2052632?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2054815?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2054815. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2054815."
    },
    {
        "instruction": "In which chromosome is SNV2054815 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2054815?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2054815, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2054815?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2054815?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2054815?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2054815?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2066672?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2066672. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2066672."
    },
    {
        "instruction": "In which chromosome is SNV2066672 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2066672?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2066672, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2066672?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2066672?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2066672?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2066672?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2057566?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2057566. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2057566."
    },
    {
        "instruction": "In which chromosome is SNV2057566 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2057566?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2057566, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2057566?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2057566?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2057566?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2057566?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 2057568?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs2057568. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/2057568."
    },
    {
        "instruction": "In which chromosome is 2057568 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 2057568?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 2057568, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for 2057568?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for 2057568?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 2057568?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 2057568?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2054573?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2054573. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2054573."
    },
    {
        "instruction": "In which chromosome is SNV2054573 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2054573?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2054573, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2054573?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2054573?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2054573?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2054573?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2050935?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2050935. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2050935."
    },
    {
        "instruction": "In which chromosome is SNV2050935 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2050935?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2050935, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2050935?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2050935?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2050935?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2050935?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2058635?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2058635. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2058635."
    },
    {
        "instruction": "In which chromosome is SNV2058635 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2058635?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2058635, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2058635?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2058635?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2058635?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2058635?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2063088?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2063088. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2063088."
    },
    {
        "instruction": "In which chromosome is DUP2063088 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2063088?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2063088, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP2063088?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2063088?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2063088?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2063088?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2075042?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2075042. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2075042."
    },
    {
        "instruction": "In which chromosome is SNV2075042 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2075042?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2075042, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2075042?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2075042?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2075042?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2075042?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2061836?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2061836. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2061836."
    },
    {
        "instruction": "In which chromosome is SNV2061836 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2061836?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2061836, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2061836?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2061836?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2061836?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2061836?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2063536?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2063536. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2063536."
    },
    {
        "instruction": "In which chromosome is SNV2063536 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2063536?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2063536, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2063536?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2063536?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2063536?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2063536?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2065165?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2065165. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2065165."
    },
    {
        "instruction": "In which chromosome is SNV2065165 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2065165?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2065165, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2065165?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2065165?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2065165?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2065165?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2067213?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2067213. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2067213."
    },
    {
        "instruction": "In which chromosome is SNV2067213 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2067213?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2067213, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2067213?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2067213?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2067213?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2067213?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2070157?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2070157. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2070157."
    },
    {
        "instruction": "In which chromosome is DEL2070157 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2070157?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2070157, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL2070157?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2070157?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2070157?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2070157?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2080091?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2080091. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2080091."
    },
    {
        "instruction": "In which chromosome is DEL2080091 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2080091?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2080091, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2080091?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2080091?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2080091?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2080091?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2087781?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2087781. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2087781."
    },
    {
        "instruction": "In which chromosome is SNV2087781 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2087781?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2087781, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2087781?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2087781?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2087781?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2087781?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2084302?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2084302. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2084302."
    },
    {
        "instruction": "In which chromosome is DEL2084302 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2084302?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2084302, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2084302?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2084302?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2084302?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2084302?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2086724?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2086724. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2086724."
    },
    {
        "instruction": "In which chromosome is DEL2086724 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2086724?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2086724, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2086724?",
        "output": "The variation length is 11 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2086724?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2086724?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2086724?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with IND2063961?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND2063961. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND2063961."
    },
    {
        "instruction": "In which chromosome is IND2063961 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND2063961?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of IND2063961, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for IND2063961?",
        "output": "The variation length is 77 base pairs."
    },
    {
        "instruction": "What is the origin for IND2063961?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND2063961?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for IND2063961?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2068704?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2068704. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2068704."
    },
    {
        "instruction": "In which chromosome is SNV2068704 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2068704?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2068704, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2068704?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2068704?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2068704?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2068704?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2075771?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2075771. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2075771."
    },
    {
        "instruction": "In which chromosome is DEL2075771 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2075771?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2075771, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2075771?",
        "output": "The variation length is 320 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2075771?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2075771?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2075771?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2076970?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2076970. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2076970."
    },
    {
        "instruction": "In which chromosome is SNV2076970 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2076970?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2076970, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2076970?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2076970?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2076970?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2076970?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2078086?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2078086. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2078086."
    },
    {
        "instruction": "In which chromosome is SNV2078086 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2078086?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2078086, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2078086?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2078086?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2078086?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2078086?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2085357?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2085357. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2085357."
    },
    {
        "instruction": "In which chromosome is DUP2085357 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2085357?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2085357, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DUP2085357?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2085357?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2085357?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2085357?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2088618?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2088618. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2088618."
    },
    {
        "instruction": "In which chromosome is SNV2088618 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2088618?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2088618, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2088618?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2088618?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2088618?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2088618?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2089565?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2089565. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2089565."
    },
    {
        "instruction": "In which chromosome is DUP2089565 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2089565?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2089565, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP2089565?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2089565?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2089565?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2089565?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with INS2088770?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsINS2088770. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/INS2088770."
    },
    {
        "instruction": "In which chromosome is INS2088770 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the INS2088770?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of INS2088770, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for INS2088770?",
        "output": "The variation length is 118 base pairs."
    },
    {
        "instruction": "What is the origin for INS2088770?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for INS2088770?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for INS2088770?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2086101?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2086101. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2086101."
    },
    {
        "instruction": "In which chromosome is SNV2086101 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2086101?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2086101, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2086101?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2086101?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2086101?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2086101?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2082629?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2082629. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2082629."
    },
    {
        "instruction": "In which chromosome is SNV2082629 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2082629?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2082629, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2082629?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2082629?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2082629?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2082629?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2090138?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2090138. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2090138."
    },
    {
        "instruction": "In which chromosome is DUP2090138 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2090138?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2090138, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP2090138?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2090138?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2090138?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2090138?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2097106?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2097106. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2097106."
    },
    {
        "instruction": "In which chromosome is DEL2097106 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2097106?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2097106, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL2097106?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2097106?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2097106?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2097106?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2081158?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2081158. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2081158."
    },
    {
        "instruction": "In which chromosome is SNV2081158 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2081158?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2081158, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2081158?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2081158?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2081158?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2081158?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2093838?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2093838. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2093838."
    },
    {
        "instruction": "In which chromosome is SNV2093838 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2093838?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2093838, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2093838?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2093838?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2093838?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2093838?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2094271?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2094271. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2094271."
    },
    {
        "instruction": "In which chromosome is SNV2094271 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2094271?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2094271, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2094271?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2094271?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2094271?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2094271?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2102036?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2102036. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2102036."
    },
    {
        "instruction": "In which chromosome is SNV2102036 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2102036?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2102036, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2102036?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2102036?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2102036?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2102036?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2100804?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2100804. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2100804."
    },
    {
        "instruction": "In which chromosome is SNV2100804 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2100804?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2100804, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2100804?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2100804?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2100804?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2100804?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2097359?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2097359. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2097359."
    },
    {
        "instruction": "In which chromosome is SNV2097359 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2097359?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2097359, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2097359?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2097359?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2097359?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2097359?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2090743?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2090743. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2090743."
    },
    {
        "instruction": "In which chromosome is SNV2090743 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2090743?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2090743, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2090743?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2090743?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2090743?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2090743?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2112348?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2112348. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2112348."
    },
    {
        "instruction": "In which chromosome is SNV2112348 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2112348?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2112348, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2112348?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2112348?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2112348?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2112348?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2093051?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2093051. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2093051."
    },
    {
        "instruction": "In which chromosome is SNV2093051 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2093051?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2093051, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2093051?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2093051?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2093051?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2093051?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with IND2109371?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsIND2109371. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/IND2109371."
    },
    {
        "instruction": "In which chromosome is IND2109371 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the IND2109371?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of IND2109371, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for IND2109371?",
        "output": "The variation length is 10 base pairs."
    },
    {
        "instruction": "What is the origin for IND2109371?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for IND2109371?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for IND2109371?",
        "output": "The resulting gene consequence is a inframe_indel."
    },
    {
        "instruction": "Which condition is asociated with SNV2105972?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2105972. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2105972."
    },
    {
        "instruction": "In which chromosome is SNV2105972 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2105972?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2105972, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2105972?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2105972?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2105972?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2105972?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2092776?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2092776. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2092776."
    },
    {
        "instruction": "In which chromosome is SNV2092776 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2092776?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2092776, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2092776?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2092776?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2092776?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2092776?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2105122?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2105122. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2105122."
    },
    {
        "instruction": "In which chromosome is SNV2105122 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2105122?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2105122, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2105122?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2105122?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2105122?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2105122?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2109311?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2109311. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2109311."
    },
    {
        "instruction": "In which chromosome is SNV2109311 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2109311?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2109311, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2109311?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2109311?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2109311?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2109311?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2117348?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2117348. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2117348."
    },
    {
        "instruction": "In which chromosome is SNV2117348 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2117348?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2117348, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2117348?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2117348?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2117348?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2117348?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2107899?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2107899. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2107899."
    },
    {
        "instruction": "In which chromosome is SNV2107899 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2107899?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2107899, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2107899?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2107899?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2107899?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2107899?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2128581?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2128581. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2128581."
    },
    {
        "instruction": "In which chromosome is SNV2128581 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2128581?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2128581, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2128581?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2128581?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2128581?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2128581?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2128978?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2128978. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2128978."
    },
    {
        "instruction": "In which chromosome is SNV2128978 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2128978?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2128978, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2128978?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2128978?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2128978?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2128978?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2109696?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2109696. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2109696."
    },
    {
        "instruction": "In which chromosome is SNV2109696 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2109696?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2109696, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2109696?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2109696?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2109696?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2109696?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2118634?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2118634. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2118634."
    },
    {
        "instruction": "In which chromosome is SNV2118634 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2118634?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2118634, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2118634?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2118634?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2118634?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2118634?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2117344?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2117344. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2117344."
    },
    {
        "instruction": "In which chromosome is DEL2117344 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2117344?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2117344, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL2117344?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2117344?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2117344?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2117344?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2125908?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2125908. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2125908."
    },
    {
        "instruction": "In which chromosome is SNV2125908 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2125908?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2125908, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2125908?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2125908?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2125908?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2125908?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2123311?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2123311. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2123311."
    },
    {
        "instruction": "In which chromosome is SNV2123311 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2123311?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2123311, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2123311?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2123311?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2123311?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2123311?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2137785?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2137785. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2137785."
    },
    {
        "instruction": "In which chromosome is SNV2137785 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2137785?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2137785, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2137785?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2137785?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2137785?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2137785?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2134908?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2134908. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2134908."
    },
    {
        "instruction": "In which chromosome is SNV2134908 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2134908?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2134908, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2134908?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2134908?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2134908?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2134908?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2122996?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2122996. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2122996."
    },
    {
        "instruction": "In which chromosome is SNV2122996 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2122996?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2122996, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2122996?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2122996?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2122996?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2122996?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2123009?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2123009. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2123009."
    },
    {
        "instruction": "In which chromosome is SNV2123009 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2123009?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2123009, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2123009?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2123009?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2123009?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2123009?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2137794?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2137794. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2137794."
    },
    {
        "instruction": "In which chromosome is SNV2137794 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2137794?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2137794, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2137794?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2137794?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2137794?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2137794?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2142471?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2142471. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2142471."
    },
    {
        "instruction": "In which chromosome is SNV2142471 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2142471?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2142471, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2142471?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2142471?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2142471?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2142471?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2138903?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2138903. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2138903."
    },
    {
        "instruction": "In which chromosome is SNV2138903 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2138903?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2138903, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2138903?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2138903?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2138903?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2138903?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2133500?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2133500. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2133500."
    },
    {
        "instruction": "In which chromosome is SNV2133500 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2133500?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2133500, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2133500?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2133500?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2133500?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2133500?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2139130?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2139130. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2139130."
    },
    {
        "instruction": "In which chromosome is SNV2139130 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2139130?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2139130, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2139130?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2139130?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2139130?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2139130?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2139965?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2139965. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2139965."
    },
    {
        "instruction": "In which chromosome is SNV2139965 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2139965?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2139965, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2139965?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2139965?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2139965?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2139965?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2148374?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2148374. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2148374."
    },
    {
        "instruction": "In which chromosome is SNV2148374 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2148374?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2148374, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2148374?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2148374?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2148374?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2148374?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2136660?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2136660. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2136660."
    },
    {
        "instruction": "In which chromosome is SNV2136660 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2136660?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2136660, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2136660?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2136660?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2136660?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2136660?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2137521?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2137521. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2137521."
    },
    {
        "instruction": "In which chromosome is DUP2137521 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2137521?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2137521, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP2137521?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2137521?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2137521?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2137521?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2155004?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2155004. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2155004."
    },
    {
        "instruction": "In which chromosome is SNV2155004 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2155004?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2155004, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2155004?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2155004?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2155004?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2155004?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2140520?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2140520. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2140520."
    },
    {
        "instruction": "In which chromosome is SNV2140520 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2140520?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2140520, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2140520?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2140520?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2140520?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2140520?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2153437?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2153437. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2153437."
    },
    {
        "instruction": "In which chromosome is SNV2153437 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2153437?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2153437, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2153437?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2153437?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2153437?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2153437?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2148369?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2148369. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2148369."
    },
    {
        "instruction": "In which chromosome is SNV2148369 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2148369?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2148369, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2148369?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2148369?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2148369?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2148369?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2153322?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2153322. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2153322."
    },
    {
        "instruction": "In which chromosome is SNV2153322 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2153322?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2153322, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2153322?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2153322?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2153322?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2153322?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2159119?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2159119. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2159119."
    },
    {
        "instruction": "In which chromosome is SNV2159119 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2159119?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2159119, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2159119?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2159119?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2159119?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2159119?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2166610?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2166610. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2166610."
    },
    {
        "instruction": "In which chromosome is SNV2166610 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2166610?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2166610, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2166610?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2166610?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2166610?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2166610?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2162980?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2162980. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2162980."
    },
    {
        "instruction": "In which chromosome is SNV2162980 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2162980?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2162980, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2162980?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2162980?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2162980?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2162980?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2162050?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2162050. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2162050."
    },
    {
        "instruction": "In which chromosome is SNV2162050 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2162050?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2162050, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV2162050?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2162050?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2162050?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2162050?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV2150535?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2150535. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2150535."
    },
    {
        "instruction": "In which chromosome is SNV2150535 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2150535?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2150535, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2150535?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2150535?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2150535?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2150535?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2175637?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2175637. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2175637."
    },
    {
        "instruction": "In which chromosome is SNV2175637 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2175637?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2175637, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2175637?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2175637?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2175637?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2175637?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2176530?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2176530. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2176530."
    },
    {
        "instruction": "In which chromosome is SNV2176530 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2176530?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2176530, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2176530?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2176530?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2176530?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2176530?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2180441?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2180441. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2180441."
    },
    {
        "instruction": "In which chromosome is SNV2180441 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2180441?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2180441, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV2180441?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2180441?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2180441?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2180441?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV2169245?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2169245. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2169245."
    },
    {
        "instruction": "In which chromosome is SNV2169245 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2169245?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2169245, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2169245?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2169245?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2169245?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2169245?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2165762?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2165762. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2165762."
    },
    {
        "instruction": "In which chromosome is SNV2165762 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2165762?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2165762, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2165762?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2165762?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2165762?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2165762?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2160282?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2160282. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2160282."
    },
    {
        "instruction": "In which chromosome is SNV2160282 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2160282?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2160282, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2160282?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2160282?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2160282?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2160282?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2161723?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2161723. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2161723."
    },
    {
        "instruction": "In which chromosome is SNV2161723 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2161723?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2161723, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2161723?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2161723?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2161723?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2161723?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2160888?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2160888. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2160888."
    },
    {
        "instruction": "In which chromosome is SNV2160888 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2160888?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2160888, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2160888?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2160888?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2160888?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2160888?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2175824?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2175824. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2175824."
    },
    {
        "instruction": "In which chromosome is SNV2175824 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2175824?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2175824, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2175824?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2175824?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2175824?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2175824?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2189863?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2189863. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2189863."
    },
    {
        "instruction": "In which chromosome is SNV2189863 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2189863?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2189863, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2189863?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2189863?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2189863?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2189863?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2187788?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2187788. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2187788."
    },
    {
        "instruction": "In which chromosome is SNV2187788 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2187788?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2187788, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2187788?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2187788?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2187788?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2187788?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2186466?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2186466. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2186466."
    },
    {
        "instruction": "In which chromosome is SNV2186466 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2186466?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2186466, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2186466?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2186466?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2186466?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2186466?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2170477?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2170477. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2170477."
    },
    {
        "instruction": "In which chromosome is SNV2170477 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2170477?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2170477, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2170477?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2170477?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2170477?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2170477?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2161187?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2161187. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2161187."
    },
    {
        "instruction": "In which chromosome is SNV2161187 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2161187?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2161187, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2161187?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2161187?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2161187?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2161187?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1874621?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1874621. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1874621."
    },
    {
        "instruction": "In which chromosome is DUP1874621 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1874621?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1874621, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP1874621?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1874621?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1874621?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1874621?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2160463?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2160463. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2160463."
    },
    {
        "instruction": "In which chromosome is SNV2160463 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2160463?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2160463, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2160463?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2160463?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2160463?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2160463?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2164698?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2164698. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2164698."
    },
    {
        "instruction": "In which chromosome is SNV2164698 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2164698?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2164698, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2164698?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2164698?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2164698?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2164698?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP2185327?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2185327. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2185327."
    },
    {
        "instruction": "In which chromosome is DUP2185327 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2185327?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2185327, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DUP2185327?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2185327?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2185327?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2185327?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2188458?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2188458. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2188458."
    },
    {
        "instruction": "In which chromosome is SNV2188458 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2188458?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2188458, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2188458?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2188458?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2188458?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2188458?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2192209?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2192209. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2192209."
    },
    {
        "instruction": "In which chromosome is SNV2192209 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2192209?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2192209, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2192209?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2192209?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2192209?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2192209?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2189581?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2189581. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2189581."
    },
    {
        "instruction": "In which chromosome is DEL2189581 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2189581?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2189581, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2189581?",
        "output": "The variation length is 10 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2189581?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2189581?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2189581?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2192439?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2192439. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2192439."
    },
    {
        "instruction": "In which chromosome is SNV2192439 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2192439?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2192439, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2192439?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2192439?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2192439?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2192439?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2177913?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2177913. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2177913."
    },
    {
        "instruction": "In which chromosome is DEL2177913 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2177913?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2177913, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL2177913?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2177913?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2177913?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2177913?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2177958?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2177958. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2177958."
    },
    {
        "instruction": "In which chromosome is SNV2177958 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2177958?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2177958, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2177958?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2177958?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2177958?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2177958?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2190856?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2190856. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2190856."
    },
    {
        "instruction": "In which chromosome is SNV2190856 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2190856?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2190856, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2190856?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2190856?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2190856?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2190856?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1875033?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1875033. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1875033."
    },
    {
        "instruction": "In which chromosome is SNV1875033 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1875033?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1875033, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1875033?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1875033?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1875033?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1875033?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1872543?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1872543. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1872543."
    },
    {
        "instruction": "In which chromosome is SNV1872543 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1872543?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1872543, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1872543?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1872543?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1872543?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1872543?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with 1879598?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/Rs1879598. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/1879598."
    },
    {
        "instruction": "In which chromosome is 1879598 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the 1879598?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of 1879598, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for 1879598?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for 1879598?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for 1879598?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for 1879598?",
        "output": "The resulting gene consequence is a inframe_indel."
    },
    {
        "instruction": "Which condition is asociated with SNV2173875?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2173875. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2173875."
    },
    {
        "instruction": "In which chromosome is SNV2173875 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2173875?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2173875, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2173875?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2173875?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2173875?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2173875?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2174131?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2174131. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2174131."
    },
    {
        "instruction": "In which chromosome is SNV2174131 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2174131?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2174131, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2174131?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2174131?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2174131?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2174131?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2186458?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2186458. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2186458."
    },
    {
        "instruction": "In which chromosome is SNV2186458 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2186458?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2186458, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2186458?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2186458?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2186458?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2186458?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2175342?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2175342. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2175342."
    },
    {
        "instruction": "In which chromosome is SNV2175342 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2175342?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2175342, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2175342?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2175342?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2175342?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2175342?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874616?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874616. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874616."
    },
    {
        "instruction": "In which chromosome is SNV1874616 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874616?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874616, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874616?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874616?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874616?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874616?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1874618?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874618. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874618."
    },
    {
        "instruction": "In which chromosome is SNV1874618 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874618?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874618, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874618?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874618?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874618?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874618?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV2176630?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2176630. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2176630."
    },
    {
        "instruction": "In which chromosome is SNV2176630 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2176630?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2176630, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2176630?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2176630?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2176630?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2176630?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2188997?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2188997. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2188997."
    },
    {
        "instruction": "In which chromosome is SNV2188997 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2188997?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2188997, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2188997?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2188997?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2188997?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2188997?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1875567?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1875567. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1875567."
    },
    {
        "instruction": "In which chromosome is SNV1875567 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1875567?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1875567, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1875567?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1875567?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1875567?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1875567?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1874611?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1874611. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1874611."
    },
    {
        "instruction": "In which chromosome is DEL1874611 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1874611?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1874611, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1874611?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1874611?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1874611?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1874612?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874612. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874612."
    },
    {
        "instruction": "In which chromosome is SNV1874612 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874612?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874612, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874612?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874612?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874612?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874612?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1874614?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874614. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874614."
    },
    {
        "instruction": "In which chromosome is SNV1874614 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874614?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874614, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1874614?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874614?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874614?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874614?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874615?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874615. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874615."
    },
    {
        "instruction": "In which chromosome is SNV1874615 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874615?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874615, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874615?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874615?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874615?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874615?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1874617?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874617. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874617."
    },
    {
        "instruction": "In which chromosome is SNV1874617 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874617?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874617, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1874617?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874617?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874617?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874617?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874619?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874619. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874619."
    },
    {
        "instruction": "In which chromosome is SNV1874619 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874619?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874619, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874619?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874619?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874619?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874619?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1871476?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1871476. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1871476."
    },
    {
        "instruction": "In which chromosome is SNV1871476 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1871476?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1871476, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1871476?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1871476?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1871476?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1871476?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1868296?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1868296. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1868296."
    },
    {
        "instruction": "In which chromosome is SNV1868296 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1868296?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1868296, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1868296?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1868296?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1868296?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1868296?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1879910?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1879910. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1879910."
    },
    {
        "instruction": "In which chromosome is SNV1879910 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1879910?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1879910, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1879910?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1879910?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1879910?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1879910?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874228?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874228. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874228."
    },
    {
        "instruction": "In which chromosome is SNV1874228 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874228?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874228, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1874228?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874228?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874228?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874228?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874933?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874933. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874933."
    },
    {
        "instruction": "In which chromosome is SNV1874933 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874933?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874933, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1874933?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874933?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874933?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874933?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1876703?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1876703. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1876703."
    },
    {
        "instruction": "In which chromosome is SNV1876703 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1876703?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1876703, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1876703?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1876703?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1876703?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1876703?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1884665?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1884665. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1884665."
    },
    {
        "instruction": "In which chromosome is SNV1884665 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1884665?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1884665, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1884665?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1884665?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1884665?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1884665?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1891336?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1891336. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1891336."
    },
    {
        "instruction": "In which chromosome is SNV1891336 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1891336?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1891336, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1891336?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1891336?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1891336?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1891336?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1871989?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1871989. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1871989."
    },
    {
        "instruction": "In which chromosome is SNV1871989 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1871989?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1871989, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1871989?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1871989?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1871989?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1871989?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1893223?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1893223. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1893223."
    },
    {
        "instruction": "In which chromosome is SNV1893223 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1893223?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1893223, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1893223?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1893223?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1893223?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1893223?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1876866?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1876866. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1876866."
    },
    {
        "instruction": "In which chromosome is SNV1876866 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1876866?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1876866, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1876866?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1876866?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1876866?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1876866?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1890197?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1890197. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1890197."
    },
    {
        "instruction": "In which chromosome is SNV1890197 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1890197?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1890197, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1890197?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1890197?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1890197?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1890197?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1887280?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1887280. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1887280."
    },
    {
        "instruction": "In which chromosome is SNV1887280 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1887280?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1887280, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1887280?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1887280?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1887280?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1887280?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1892265?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1892265. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1892265."
    },
    {
        "instruction": "In which chromosome is SNV1892265 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1892265?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1892265, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1892265?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1892265?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1892265?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1892265?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1883047?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1883047. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1883047."
    },
    {
        "instruction": "In which chromosome is SNV1883047 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1883047?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1883047, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1883047?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1883047?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1883047?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1883047?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1886712?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1886712. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1886712."
    },
    {
        "instruction": "In which chromosome is DUP1886712 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1886712?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1886712, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for DUP1886712?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1886712?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1886712?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1886712?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1877482?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1877482. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1877482."
    },
    {
        "instruction": "In which chromosome is SNV1877482 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1877482?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1877482, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1877482?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1877482?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1877482?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1877482?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874066?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874066. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874066."
    },
    {
        "instruction": "In which chromosome is SNV1874066 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874066?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874066, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1874066?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874066?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874066?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874066?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1892473?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1892473. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1892473."
    },
    {
        "instruction": "In which chromosome is SNV1892473 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1892473?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1892473, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1892473?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1892473?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1892473?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1892473?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1883856?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1883856. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1883856."
    },
    {
        "instruction": "In which chromosome is SNV1883856 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1883856?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1883856, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1883856?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1883856?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1883856?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1883856?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1900240?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1900240. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1900240."
    },
    {
        "instruction": "In which chromosome is SNV1900240 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1900240?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1900240, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1900240?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1900240?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1900240?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1900240?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1892866?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1892866. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1892866."
    },
    {
        "instruction": "In which chromosome is DEL1892866 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1892866?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1892866, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for DEL1892866?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1892866?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1892866?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1892866?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1906418?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1906418. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1906418."
    },
    {
        "instruction": "In which chromosome is SNV1906418 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1906418?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1906418, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1906418?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1906418?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1906418?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1906418?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1905295?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1905295. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1905295."
    },
    {
        "instruction": "In which chromosome is SNV1905295 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1905295?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1905295, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1905295?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1905295?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1905295?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1905295?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1901836?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1901836. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1901836."
    },
    {
        "instruction": "In which chromosome is SNV1901836 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1901836?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1901836, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1901836?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1901836?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1901836?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1901836?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1684824?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1684824. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1684824."
    },
    {
        "instruction": "In which chromosome is SNV1684824 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1684824?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1684824, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1684824?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1684824?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1684824?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1684824?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1826673?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1826673. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1826673."
    },
    {
        "instruction": "In which chromosome is SNV1826673 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1826673?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1826673, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1826673?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1826673?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1826673?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1826673?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1827453?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1827453. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1827453."
    },
    {
        "instruction": "In which chromosome is SNV1827453 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1827453?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1827453, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1827453?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1827453?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1827453?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1827453?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1899855?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1899855. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1899855."
    },
    {
        "instruction": "In which chromosome is SNV1899855 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1899855?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1899855, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1899855?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1899855?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1899855?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1899855?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1802703?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1802703. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1802703."
    },
    {
        "instruction": "In which chromosome is SNV1802703 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1802703?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1802703, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1802703?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1802703?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1802703?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1802703?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1838822?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1838822. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1838822."
    },
    {
        "instruction": "In which chromosome is SNV1838822 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1838822?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1838822, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1838822?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1838822?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1838822?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1838822?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1843083?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1843083. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1843083."
    },
    {
        "instruction": "In which chromosome is SNV1843083 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1843083?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1843083, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1843083?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1843083?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1843083?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1843083?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1843380?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1843380. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1843380."
    },
    {
        "instruction": "In which chromosome is SNV1843380 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1843380?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1843380, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1843380?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1843380?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1843380?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1843380?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1850018?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1850018. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1850018."
    },
    {
        "instruction": "In which chromosome is SNV1850018 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1850018?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1850018, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1850018?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1850018?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1850018?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1850018?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1840490?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1840490. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1840490."
    },
    {
        "instruction": "In which chromosome is SNV1840490 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1840490?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1840490, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1840490?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1840490?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1840490?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1840490?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1840753?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1840753. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1840753."
    },
    {
        "instruction": "In which chromosome is SNV1840753 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1840753?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1840753, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1840753?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1840753?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1840753?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1840753?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1902797?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1902797. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1902797."
    },
    {
        "instruction": "In which chromosome is SNV1902797 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1902797?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1902797, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1902797?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1902797?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1902797?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1902797?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1792159?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1792159. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1792159."
    },
    {
        "instruction": "In which chromosome is SNV1792159 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1792159?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1792159, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1792159?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1792159?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1792159?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1792159?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1823443?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1823443. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1823443."
    },
    {
        "instruction": "In which chromosome is SNV1823443 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1823443?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1823443, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1823443?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1823443?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1823443?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1823443?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1899582?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1899582. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1899582."
    },
    {
        "instruction": "In which chromosome is SNV1899582 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1899582?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1899582, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1899582?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1899582?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1899582?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1899582?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1831231?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1831231. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1831231."
    },
    {
        "instruction": "In which chromosome is SNV1831231 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1831231?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1831231, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1831231?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1831231?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1831231?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1831231?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1838056?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1838056. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1838056."
    },
    {
        "instruction": "In which chromosome is SNV1838056 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1838056?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1838056, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1838056?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1838056?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1838056?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1838056?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1831721?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1831721. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1831721."
    },
    {
        "instruction": "In which chromosome is SNV1831721 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1831721?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1831721, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1831721?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1831721?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1831721?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1831721?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1843574?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1843574. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1843574."
    },
    {
        "instruction": "In which chromosome is SNV1843574 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1843574?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1843574, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1843574?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1843574?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1843574?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1843574?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1847469?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1847469. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1847469."
    },
    {
        "instruction": "In which chromosome is SNV1847469 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1847469?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1847469, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1847469?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1847469?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1847469?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1847469?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1848427?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1848427. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1848427."
    },
    {
        "instruction": "In which chromosome is SNV1848427 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1848427?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1848427, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1848427?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1848427?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1848427?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1848427?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1841885?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1841885. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1841885."
    },
    {
        "instruction": "In which chromosome is SNV1841885 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1841885?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1841885, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1841885?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1841885?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1841885?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1841885?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1806469?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1806469. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1806469."
    },
    {
        "instruction": "In which chromosome is SNV1806469 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1806469?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1806469, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1806469?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1806469?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1806469?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1806469?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1855262?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1855262. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1855262."
    },
    {
        "instruction": "In which chromosome is SNV1855262 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1855262?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1855262, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1855262?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1855262?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1855262?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1855262?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1820410?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1820410. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1820410."
    },
    {
        "instruction": "In which chromosome is SNV1820410 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1820410?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1820410, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1820410?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1820410?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1820410?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1820410?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1825147?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1825147. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1825147."
    },
    {
        "instruction": "In which chromosome is SNV1825147 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1825147?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1825147, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1825147?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1825147?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1825147?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1825147?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS376886420 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS376886420 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS376886420 SNP."
    },
    {
        "instruction": "In which chromosome is RS376886420 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS376886420 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS376886420 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS376886420 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS376886420 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS376886420 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS376886420 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS750293921 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750293921 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750293921 SNP."
    },
    {
        "instruction": "In which chromosome is RS750293921 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750293921 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750293921 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750293921 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750293921 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750293921 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750293921 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS780733860 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780733860 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780733860 SNP."
    },
    {
        "instruction": "In which chromosome is RS780733860 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780733860 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780733860 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS780733860 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS780733860 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780733860 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780733860 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS766131342 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS766131342 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS766131342 SNP."
    },
    {
        "instruction": "In which chromosome is RS766131342 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS766131342 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS766131342 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS766131342 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS766131342 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS766131342 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS766131342 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1357310270 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1357310270 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1357310270 SNP."
    },
    {
        "instruction": "In which chromosome is RS1357310270 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1357310270 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1357310270 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1357310270 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1357310270 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1357310270 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1357310270 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS776175164 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS776175164 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS776175164 SNP."
    },
    {
        "instruction": "In which chromosome is RS776175164 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS776175164 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS776175164 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS776175164 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS776175164 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS776175164 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS776175164 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS753350745 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS753350745 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS753350745 SNP."
    },
    {
        "instruction": "In which chromosome is RS753350745 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS753350745 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS753350745 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS753350745 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS753350745 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS753350745 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS753350745 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1563888782 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1563888782 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1563888782 SNP."
    },
    {
        "instruction": "In which chromosome is RS1563888782 SNP located?",
        "output": "It is located in the chromosome 9."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1563888782 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1563888782 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1563888782 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1563888782 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1563888782 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1563888782 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS138033832 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS138033832 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS138033832 SNP."
    },
    {
        "instruction": "In which chromosome is RS138033832 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS138033832 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS138033832 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS138033832 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS138033832 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS138033832 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS138033832 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS754814477 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS754814477 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS754814477 SNP."
    },
    {
        "instruction": "In which chromosome is RS754814477 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS754814477 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS754814477 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS754814477 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS754814477 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS754814477 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS754814477 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS770072166 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770072166 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770072166 SNP."
    },
    {
        "instruction": "In which chromosome is RS770072166 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770072166 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770072166 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS770072166 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770072166 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770072166 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770072166 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS951251256 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS951251256 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS951251256 SNP."
    },
    {
        "instruction": "In which chromosome is RS951251256 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS951251256 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS951251256 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS951251256 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS951251256 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS951251256 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS951251256 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1014776340 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1014776340 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1014776340 SNP."
    },
    {
        "instruction": "In which chromosome is RS1014776340 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1014776340 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1014776340 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS1014776340 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1014776340 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1014776340 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1014776340 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952831176 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952831176 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952831176 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952831176 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952831176 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952831176 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952831176 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952831176 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952831176 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952831176 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1001725?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1001725. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1001725."
    },
    {
        "instruction": "In which chromosome is DEL1001725 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1001725?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1001725, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1001725?",
        "output": "The variation length is 64 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1001725?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1001725?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with RS774196937 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS774196937 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS774196937 SNP."
    },
    {
        "instruction": "In which chromosome is RS774196937 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS774196937 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS774196937 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS774196937 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS774196937 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS774196937 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS774196937 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1022346?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1022346. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1022346."
    },
    {
        "instruction": "In which chromosome is DUP1022346 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1022346?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1022346, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP1022346?",
        "output": "The variation length is 442325 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1022346?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1022346?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with RS1952051803 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952051803 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952051803 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952051803 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952051803 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952051803 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952051803 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952051803 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952051803 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952051803 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048357?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048357. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048357."
    },
    {
        "instruction": "In which chromosome is SNV1048357 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048357?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048357, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048357?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048357?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048357?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048357?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048343?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048343. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048343."
    },
    {
        "instruction": "In which chromosome is SNV1048343 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048343?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048343, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048343?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048343?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048343?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048343?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080103?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080103. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080103."
    },
    {
        "instruction": "In which chromosome is SNV1080103 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080103?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080103, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080103?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080103?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080103?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080103?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123363?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123363. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123363."
    },
    {
        "instruction": "In which chromosome is SNV1123363 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123363?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123363, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123363?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123363?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123363?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123363?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1440445?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1440445. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1440445."
    },
    {
        "instruction": "In which chromosome is SNV1440445 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1440445?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1440445, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1440445?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1440445?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1440445?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1440445?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1480515?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1480515. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1480515."
    },
    {
        "instruction": "In which chromosome is SNV1480515 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1480515?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1480515, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1480515?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1480515?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1480515?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1480515?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1390924?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1390924. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1390924."
    },
    {
        "instruction": "In which chromosome is SNV1390924 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1390924?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1390924, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1390924?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1390924?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1390924?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1390924?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1364583?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1364583. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1364583."
    },
    {
        "instruction": "In which chromosome is SNV1364583 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1364583?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1364583, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1364583?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1364583?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1364583?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1364583?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS200985890 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200985890 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200985890 SNP."
    },
    {
        "instruction": "In which chromosome is RS200985890 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200985890 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200985890 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS200985890 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200985890 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200985890 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200985890 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1601043?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1601043. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1601043."
    },
    {
        "instruction": "In which chromosome is SNV1601043 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1601043?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1601043, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1601043?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1601043?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1601043?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1601043?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1540123?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1540123. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1540123."
    },
    {
        "instruction": "In which chromosome is SNV1540123 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1540123?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1540123, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1540123?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1540123?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1540123?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1540123?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1589352?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1589352. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1589352."
    },
    {
        "instruction": "In which chromosome is SNV1589352 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1589352?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1589352, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1589352?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1589352?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1589352?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1589352?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1655405?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1655405. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1655405."
    },
    {
        "instruction": "In which chromosome is SNV1655405 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1655405?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1655405, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1655405?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1655405?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1655405?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1655405?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1620121?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1620121. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1620121."
    },
    {
        "instruction": "In which chromosome is SNV1620121 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1620121?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1620121, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1620121?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1620121?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1620121?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1620121?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DUP1795436?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1795436. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1795436."
    },
    {
        "instruction": "In which chromosome is DUP1795436 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1795436?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1795436, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP1795436?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1795436?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1795436?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP1795436?",
        "output": "The resulting gene consequence is a inframe_indel."
    },
    {
        "instruction": "Which condition is asociated with DEL1939190?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939190. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939190."
    },
    {
        "instruction": "In which chromosome is DEL1939190 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939190?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939190, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939190?",
        "output": "The variation length is 1439 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939190?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939190?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939191?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939191. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939191."
    },
    {
        "instruction": "In which chromosome is DEL1939191 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939191?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939191, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL1939191?",
        "output": "The variation length is 315690 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939191?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939191?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939192?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939192. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939192."
    },
    {
        "instruction": "In which chromosome is DEL1939192 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939192?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939192, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939192?",
        "output": "The variation length is 8059 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939192?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939192?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939193?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939193. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939193."
    },
    {
        "instruction": "In which chromosome is DEL1939193 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939193?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939193, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939193?",
        "output": "The variation length is 4546 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939193?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939193?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939194?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939194. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939194."
    },
    {
        "instruction": "In which chromosome is DEL1939194 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939194?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939194, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939194?",
        "output": "The variation length is 648 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939194?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939194?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939195?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939195. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939195."
    },
    {
        "instruction": "In which chromosome is DEL1939195 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939195?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939195, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939195?",
        "output": "The variation length is 189 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939195?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939195?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939196?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939196. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939196."
    },
    {
        "instruction": "In which chromosome is DEL1939196 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939196?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939196, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939196?",
        "output": "The variation length is 8110 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939196?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939196?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939197?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939197. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939197."
    },
    {
        "instruction": "In which chromosome is DEL1939197 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939197?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939197, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939197?",
        "output": "The variation length is 5285 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939197?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939197?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939198?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939198. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939198."
    },
    {
        "instruction": "In which chromosome is DEL1939198 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939198?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939198, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939198?",
        "output": "The variation length is 36404 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939198?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939198?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939199?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939199. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939199."
    },
    {
        "instruction": "In which chromosome is DEL1939199 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939199?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939199, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939199?",
        "output": "The variation length is 3964 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939199?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939199?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DUP1939200?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP1939200. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP1939200."
    },
    {
        "instruction": "In which chromosome is DUP1939200 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP1939200?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP1939200, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP1939200?",
        "output": "The variation length is 8110 base pairs."
    },
    {
        "instruction": "What is the origin for DUP1939200?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP1939200?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "Which condition is asociated with DEL1939201?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939201. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939201."
    },
    {
        "instruction": "In which chromosome is DEL1939201 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939201?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939201, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939201?",
        "output": "The variation length is 1463 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939201?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939201?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1939202?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1939202. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1939202."
    },
    {
        "instruction": "In which chromosome is DEL1939202 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1939202?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1939202, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1939202?",
        "output": "The variation length is 3716 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1939202?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1939202?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV1941094?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1941094. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1941094."
    },
    {
        "instruction": "In which chromosome is SNV1941094 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1941094?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1941094, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1941094?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1941094?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1941094?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1941094?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1323410?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1323410. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1323410."
    },
    {
        "instruction": "In which chromosome is DEL1323410 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1323410?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1323410, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1323410?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1323410?",
        "output": "The origin is de novo."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1323410?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1323410?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS977436301 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS977436301 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS977436301 SNP."
    },
    {
        "instruction": "In which chromosome is RS977436301 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS977436301 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS977436301 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS977436301 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS977436301 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS977436301 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS977436301 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1217977493 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1217977493 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1217977493 SNP."
    },
    {
        "instruction": "In which chromosome is RS1217977493 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1217977493 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1217977493 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1217977493 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1217977493 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1217977493 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1217977493 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1063006?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063006. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063006."
    },
    {
        "instruction": "In which chromosome is SNV1063006 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063006?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063006, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063006?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063006?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063006?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063006?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778871 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778871 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778871 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778871 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778871 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778871 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778871 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778871 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778871 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778871 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS143948310 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS143948310 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS143948310 SNP."
    },
    {
        "instruction": "In which chromosome is RS143948310 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS143948310 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS143948310 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS143948310 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS143948310 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS143948310 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS143948310 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS750136284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750136284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750136284 SNP."
    },
    {
        "instruction": "In which chromosome is RS750136284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750136284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750136284 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750136284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750136284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750136284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750136284 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555284956 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555284956 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555284956 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555284956 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555284956 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555284956 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555284956 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555284956 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555284956 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555284956 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS754183765 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS754183765 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS754183765 SNP."
    },
    {
        "instruction": "In which chromosome is RS754183765 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS754183765 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS754183765 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS754183765 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS754183765 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS754183765 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS754183765 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593448449 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593448449 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593448449 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593448449 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593448449 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593448449 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593448449 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593448449 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593448449 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593448449 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593445246 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445246 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445246 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445246 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445246 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445246 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593445246 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445246 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445246 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445246 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS17071686 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS17071686 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS17071686 SNP."
    },
    {
        "instruction": "In which chromosome is RS17071686 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS17071686 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS17071686 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS17071686 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS17071686 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS17071686 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS17071686 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS774706300 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS774706300 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS774706300 SNP."
    },
    {
        "instruction": "In which chromosome is RS774706300 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS774706300 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS774706300 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS774706300 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS774706300 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS774706300 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS774706300 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048363?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048363. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048363."
    },
    {
        "instruction": "In which chromosome is SNV1048363 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048363?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048363, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048363?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048363?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048363?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048363?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1279151?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1279151. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1279151."
    },
    {
        "instruction": "In which chromosome is SNV1279151 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1279151?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1279151, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1279151?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1279151?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1279151?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1279151?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1282558?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1282558. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1282558."
    },
    {
        "instruction": "In which chromosome is SNV1282558 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1282558?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1282558, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1282558?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1282558?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1282558?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1282558?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1670555?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1670555. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1670555."
    },
    {
        "instruction": "In which chromosome is SNV1670555 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1670555?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1670555, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1670555?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1670555?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1670555?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1670555?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1236830240 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1236830240 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1236830240 SNP."
    },
    {
        "instruction": "In which chromosome is RS1236830240 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1236830240 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1236830240 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1236830240 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1236830240 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1236830240 SNP?",
        "output": "The variation is a Insertion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1236830240 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1275629547 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1275629547 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1275629547 SNP."
    },
    {
        "instruction": "In which chromosome is RS1275629547 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1275629547 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1275629547 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1275629547 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1275629547 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1275629547 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1275629547 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1344531248 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1344531248 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1344531248 SNP."
    },
    {
        "instruction": "In which chromosome is RS1344531248 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1344531248 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1344531248 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1344531248 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1344531248 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1344531248 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1344531248 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1458608158 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1458608158 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1458608158 SNP."
    },
    {
        "instruction": "In which chromosome is RS1458608158 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1458608158 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1458608158 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1458608158 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1458608158 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1458608158 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1458608158 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1200570253 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1200570253 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1200570253 SNP."
    },
    {
        "instruction": "In which chromosome is RS1200570253 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1200570253 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1200570253 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1200570253 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS1200570253 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1200570253 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1200570253 SNP?",
        "output": "The resulting gene consequence is a inframe_indel."
    },
    {
        "instruction": "Which condition is asociated with RS1404056158 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1404056158 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1404056158 SNP."
    },
    {
        "instruction": "In which chromosome is RS1404056158 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1404056158 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1404056158 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1404056158 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1404056158 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1404056158 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1404056158 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1198561901 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1198561901 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1198561901 SNP."
    },
    {
        "instruction": "In which chromosome is RS1198561901 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1198561901 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1198561901 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1198561901 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1198561901 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1198561901 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1198561901 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1852314?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1852314. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1852314."
    },
    {
        "instruction": "In which chromosome is SNV1852314 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1852314?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1852314, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1852314?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1852314?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1852314?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1852314?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1826560?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1826560. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1826560."
    },
    {
        "instruction": "In which chromosome is SNV1826560 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1826560?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1826560, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1826560?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1826560?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1826560?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1826560?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS554834063 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS554834063 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS554834063 SNP."
    },
    {
        "instruction": "In which chromosome is RS554834063 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS554834063 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS554834063 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS554834063 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS554834063 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS554834063 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS554834063 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS759079385 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS759079385 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS759079385 SNP."
    },
    {
        "instruction": "In which chromosome is RS759079385 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS759079385 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS759079385 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS759079385 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS759079385 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS759079385 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS759079385 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with DEL652364?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL652364. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL652364."
    },
    {
        "instruction": "In which chromosome is DEL652364 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL652364?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL652364, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL652364?",
        "output": "The variation length is 140 base pairs."
    },
    {
        "instruction": "What is the origin for DEL652364?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL652364?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL820582?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL820582. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL820582."
    },
    {
        "instruction": "In which chromosome is DEL820582 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL820582?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL820582, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL820582?",
        "output": "The variation length is 166 base pairs."
    },
    {
        "instruction": "What is the origin for DEL820582?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL820582?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DEL1057633?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1057633. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1057633."
    },
    {
        "instruction": "In which chromosome is DEL1057633 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1057633?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1057633, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1057633?",
        "output": "The variation length is 161 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1057633?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1057633?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "Which condition is asociated with DUP2418598?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDUP2418598. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DUP2418598."
    },
    {
        "instruction": "In which chromosome is DUP2418598 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DUP2418598?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DUP2418598, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DUP2418598?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for DUP2418598?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DUP2418598?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for DUP2418598?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2418605?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2418605. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2418605."
    },
    {
        "instruction": "In which chromosome is DEL2418605 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2418605?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2418605, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL2418605?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2418605?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2418605?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2418605?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2418620?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2418620. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2418620."
    },
    {
        "instruction": "In which chromosome is DEL2418620 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2418620?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2418620, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL2418620?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2418620?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2418620?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2418620?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with DEL2418624?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL2418624. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL2418624."
    },
    {
        "instruction": "In which chromosome is DEL2418624 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL2418624?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL2418624, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for DEL2418624?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for DEL2418624?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL2418624?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL2418624?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853293 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853293 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853293 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853293 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853293 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853293 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS137853293 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853293 SNP?",
        "output": "The origin is de novo."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853293 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853293 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778842 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778842 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778842 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778842 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778842 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778842 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778842 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778842 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778842 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778842 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS398123331 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS398123331 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS398123331 SNP."
    },
    {
        "instruction": "In which chromosome is RS398123331 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS398123331 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS398123331 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS398123331 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS398123331 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS398123331 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS398123331 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778848 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778848 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778848 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778848 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778848 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778848 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778848 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778848 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778848 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778848 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS886042357 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886042357 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886042357 SNP."
    },
    {
        "instruction": "In which chromosome is RS886042357 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886042357 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886042357 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS886042357 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886042357 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886042357 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886042357 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS886043138 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886043138 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886043138 SNP."
    },
    {
        "instruction": "In which chromosome is RS886043138 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886043138 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886043138 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS886043138 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886043138 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886043138 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886043138 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS794727481 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS794727481 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS794727481 SNP."
    },
    {
        "instruction": "In which chromosome is RS794727481 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS794727481 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS794727481 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS794727481 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS794727481 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS794727481 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS794727481 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS201258424 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201258424 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201258424 SNP."
    },
    {
        "instruction": "In which chromosome is RS201258424 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201258424 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201258424 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS201258424 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201258424 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201258424 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201258424 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS727504121 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS727504121 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS727504121 SNP."
    },
    {
        "instruction": "In which chromosome is RS727504121 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS727504121 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS727504121 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS727504121 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS727504121 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS727504121 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS727504121 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS886043247 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886043247 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886043247 SNP."
    },
    {
        "instruction": "In which chromosome is RS886043247 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886043247 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886043247 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS886043247 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886043247 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886043247 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886043247 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS372815788 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS372815788 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS372815788 SNP."
    },
    {
        "instruction": "In which chromosome is RS372815788 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS372815788 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS372815788 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS372815788 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS372815788 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS372815788 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS372815788 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS747048469 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS747048469 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS747048469 SNP."
    },
    {
        "instruction": "In which chromosome is RS747048469 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS747048469 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS747048469 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS747048469 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS747048469 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS747048469 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS747048469 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS121913302 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913302 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913302 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913302 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913302 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913302 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913302 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913302 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913302 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913302 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS121913300 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913300 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913300 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913300 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913300 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913300 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913300 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913300 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913300 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913300 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS201458896 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201458896 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201458896 SNP."
    },
    {
        "instruction": "In which chromosome is RS201458896 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201458896 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201458896 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS201458896 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201458896 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201458896 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201458896 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS375751988 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS375751988 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS375751988 SNP."
    },
    {
        "instruction": "In which chromosome is RS375751988 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS375751988 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS375751988 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS375751988 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS375751988 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS375751988 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS375751988 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS775061547 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775061547 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775061547 SNP."
    },
    {
        "instruction": "In which chromosome is RS775061547 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775061547 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775061547 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS775061547 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775061547 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775061547 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775061547 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1515238?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1515238. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1515238."
    },
    {
        "instruction": "In which chromosome is SNV1515238 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1515238?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1515238, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1515238?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1515238?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1515238?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1515238?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151539 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151539 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151539 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151539 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151539 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151539 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS4151539 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151539 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151539 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151539 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151534 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151534 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151534 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151534 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151534 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151534 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS4151534 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151534 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151534 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151534 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS148980395 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS148980395 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS148980395 SNP."
    },
    {
        "instruction": "In which chromosome is RS148980395 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS148980395 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS148980395 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS148980395 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS148980395 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS148980395 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS148980395 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151630 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151630 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151630 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151630 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151630 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151630 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS4151630 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151630 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151630 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151630 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151635 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151635 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151635 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151635 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151635 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151635 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS4151635 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151635 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151635 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151635 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS768155412 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS768155412 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS768155412 SNP."
    },
    {
        "instruction": "In which chromosome is RS768155412 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS768155412 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS768155412 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS768155412 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS768155412 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS768155412 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS768155412 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050270 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050270 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050270 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050270 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050270 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050270 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS886050270 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050270 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050270 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050270 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050271 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050271 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050271 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050271 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050271 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050271 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050271 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050271 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050271 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050271 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS766968771 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS766968771 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS766968771 SNP."
    },
    {
        "instruction": "In which chromosome is RS766968771 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS766968771 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS766968771 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS766968771 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS766968771 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS766968771 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS766968771 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050276 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050276 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050276 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050276 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050276 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050276 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050276 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050276 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050276 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050276 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050278 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050278 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050278 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050278 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050278 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050278 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050278 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050278 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050278 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050278 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS139023385 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS139023385 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS139023385 SNP."
    },
    {
        "instruction": "In which chromosome is RS139023385 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS139023385 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS139023385 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS139023385 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS139023385 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS139023385 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS139023385 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050267 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050267 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050267 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050267 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050267 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050267 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050267 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050267 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050267 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050267 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050284 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050284 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050284 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050268 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050268 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050268 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050268 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050268 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050268 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050268 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050268 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050268 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050268 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050285 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050285 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050285 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050285 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050285 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050285 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050285 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050285 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050285 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050285 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092903 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092903 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092903 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092903 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092903 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092903 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS3092903 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092903 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092903 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092903 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS749495284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS749495284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS749495284 SNP."
    },
    {
        "instruction": "In which chromosome is RS749495284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS749495284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS749495284 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS749495284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS749495284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS749495284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS749495284 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050282 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050282 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050282 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050282 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050282 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050282 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050282 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050282 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050282 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050282 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050273 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050273 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050273 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050273 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050273 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050273 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050273 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050273 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050273 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050273 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS746086958 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746086958 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746086958 SNP."
    },
    {
        "instruction": "In which chromosome is RS746086958 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746086958 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746086958 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS746086958 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS746086958 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746086958 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746086958 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050274 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050274 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050274 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050274 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050274 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050274 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050274 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050274 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050274 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050274 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS117865557 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS117865557 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS117865557 SNP."
    },
    {
        "instruction": "In which chromosome is RS117865557 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS117865557 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS117865557 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS117865557 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS117865557 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS117865557 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS117865557 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS115108608 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS115108608 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS115108608 SNP."
    },
    {
        "instruction": "In which chromosome is RS115108608 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS115108608 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS115108608 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS115108608 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS115108608 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS115108608 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS115108608 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050265 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050265 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050265 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050265 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050265 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050265 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050265 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050265 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050265 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050265 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050283 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050283 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050283 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050283 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050283 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050283 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050283 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050283 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050283 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050283 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS143685082 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS143685082 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS143685082 SNP."
    },
    {
        "instruction": "In which chromosome is RS143685082 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS143685082 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS143685082 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS143685082 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS143685082 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS143685082 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS143685082 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050279 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050279 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050279 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050279 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050279 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050279 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050279 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050279 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050279 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050279 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050281 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050281 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050281 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050281 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050281 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050281 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050281 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050281 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050281 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050281 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS143536240 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS143536240 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS143536240 SNP."
    },
    {
        "instruction": "In which chromosome is RS143536240 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS143536240 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS143536240 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS143536240 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS143536240 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS143536240 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS143536240 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS540108904 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS540108904 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS540108904 SNP."
    },
    {
        "instruction": "In which chromosome is RS540108904 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS540108904 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS540108904 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS540108904 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS540108904 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS540108904 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS540108904 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050286 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050286 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050286 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050286 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050286 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050286 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050286 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050286 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050286 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050286 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS750581965 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750581965 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750581965 SNP."
    },
    {
        "instruction": "In which chromosome is RS750581965 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750581965 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750581965 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750581965 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750581965 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750581965 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750581965 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS765537411 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS765537411 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS765537411 SNP."
    },
    {
        "instruction": "In which chromosome is RS765537411 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS765537411 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS765537411 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS765537411 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS765537411 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS765537411 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS765537411 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050275 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050275 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050275 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050275 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050275 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050275 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050275 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050275 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050275 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050275 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151631 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151631 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151631 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151631 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151631 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151631 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS4151631 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151631 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151631 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151631 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050266 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050266 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050266 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050266 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050266 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050266 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050266 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050266 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050266 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050266 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151633 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151633 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151633 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151633 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151633 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151633 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS4151633 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151633 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151633 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151633 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS551747882 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS551747882 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS551747882 SNP."
    },
    {
        "instruction": "In which chromosome is RS551747882 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS551747882 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS551747882 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS551747882 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS551747882 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS551747882 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS551747882 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS370088029 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS370088029 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS370088029 SNP."
    },
    {
        "instruction": "In which chromosome is RS370088029 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS370088029 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS370088029 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS370088029 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS370088029 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS370088029 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS370088029 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS571383547 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS571383547 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS571383547 SNP."
    },
    {
        "instruction": "In which chromosome is RS571383547 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS571383547 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS571383547 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS571383547 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS571383547 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS571383547 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS571383547 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS886050280 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886050280 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886050280 SNP."
    },
    {
        "instruction": "In which chromosome is RS886050280 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886050280 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886050280 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS886050280 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886050280 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886050280 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886050280 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS367578442 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367578442 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367578442 SNP."
    },
    {
        "instruction": "In which chromosome is RS367578442 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367578442 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367578442 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS367578442 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367578442 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367578442 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367578442 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS367578442 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367578442 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367578442 SNP."
    },
    {
        "instruction": "In which chromosome is RS367578442 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367578442 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367578442 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS367578442 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367578442 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367578442 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367578442 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS149359120 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS149359120 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS149359120 SNP."
    },
    {
        "instruction": "In which chromosome is RS149359120 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS149359120 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS149359120 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS149359120 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS149359120 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS149359120 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS149359120 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS202031219 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS202031219 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS202031219 SNP."
    },
    {
        "instruction": "In which chromosome is RS202031219 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS202031219 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS202031219 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS202031219 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS202031219 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS202031219 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS202031219 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS149800437 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS149800437 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS149800437 SNP."
    },
    {
        "instruction": "In which chromosome is RS149800437 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS149800437 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS149800437 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS149800437 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS149800437 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS149800437 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS149800437 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS369830657 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS369830657 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS369830657 SNP."
    },
    {
        "instruction": "In which chromosome is RS369830657 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS369830657 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS369830657 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS369830657 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS369830657 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS369830657 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS369830657 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS767232453 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS767232453 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS767232453 SNP."
    },
    {
        "instruction": "In which chromosome is RS767232453 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS767232453 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS767232453 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS767232453 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS767232453 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS767232453 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS767232453 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1167280920 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1167280920 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1167280920 SNP."
    },
    {
        "instruction": "In which chromosome is RS1167280920 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1167280920 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1167280920 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS1167280920 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1167280920 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1167280920 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1167280920 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1470523018 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1470523018 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1470523018 SNP."
    },
    {
        "instruction": "In which chromosome is RS1470523018 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1470523018 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1470523018 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS1470523018 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1470523018 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1470523018 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1470523018 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS542783532 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS542783532 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS542783532 SNP."
    },
    {
        "instruction": "In which chromosome is RS542783532 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS542783532 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS542783532 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS542783532 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS542783532 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS542783532 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS542783532 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778640 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778640 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778640 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778640 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778640 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778640 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS587778640 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778640 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778640 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778640 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS750459929 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750459929 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750459929 SNP."
    },
    {
        "instruction": "In which chromosome is RS750459929 SNP located?",
        "output": "It is located in the chromosome 14."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750459929 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750459929 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS750459929 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750459929 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750459929 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750459929 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS773116120 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS773116120 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS773116120 SNP."
    },
    {
        "instruction": "In which chromosome is RS773116120 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS773116120 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS773116120 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS773116120 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS773116120 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS773116120 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS773116120 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS374523971 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS374523971 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS374523971 SNP."
    },
    {
        "instruction": "In which chromosome is RS374523971 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS374523971 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS374523971 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS374523971 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS374523971 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS374523971 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS374523971 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092900 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092900 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092900 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092900 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092900 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092900 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS3092900 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092900 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092900 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092900 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS148992508 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS148992508 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS148992508 SNP."
    },
    {
        "instruction": "In which chromosome is RS148992508 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS148992508 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS148992508 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS148992508 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS148992508 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS148992508 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS148992508 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS762809210 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762809210 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762809210 SNP."
    },
    {
        "instruction": "In which chromosome is RS762809210 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762809210 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762809210 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS762809210 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762809210 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762809210 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762809210 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949506622 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949506622 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949506622 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949506622 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949506622 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949506622 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949506622 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949506622 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949506622 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949506622 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS547352312 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS547352312 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS547352312 SNP."
    },
    {
        "instruction": "In which chromosome is RS547352312 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS547352312 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS547352312 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS547352312 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS547352312 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS547352312 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS547352312 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS201554179 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201554179 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201554179 SNP."
    },
    {
        "instruction": "In which chromosome is RS201554179 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201554179 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201554179 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS201554179 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201554179 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201554179 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201554179 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949337308 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949337308 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949337308 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949337308 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949337308 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949337308 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949337308 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949337308 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949337308 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949337308 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949530910 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949530910 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949530910 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949530910 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949530910 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949530910 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949530910 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949530910 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949530910 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949530910 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949531949 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949531949 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949531949 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949531949 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949531949 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949531949 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949531949 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949531949 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949531949 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949531949 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1450335586 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1450335586 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1450335586 SNP."
    },
    {
        "instruction": "In which chromosome is RS1450335586 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1450335586 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1450335586 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1450335586 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1450335586 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1450335586 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1450335586 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952049136 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952049136 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952049136 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952049136 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952049136 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952049136 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952049136 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952049136 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952049136 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952049136 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952049790 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952049790 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952049790 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952049790 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952049790 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952049790 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952049790 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952049790 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952049790 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952049790 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS762766187 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762766187 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762766187 SNP."
    },
    {
        "instruction": "In which chromosome is RS762766187 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762766187 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762766187 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS762766187 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762766187 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762766187 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762766187 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952456285 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952456285 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952456285 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952456285 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952456285 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952456285 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952456285 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952456285 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952456285 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952456285 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1043605723 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1043605723 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1043605723 SNP."
    },
    {
        "instruction": "In which chromosome is RS1043605723 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1043605723 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1043605723 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1043605723 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1043605723 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1043605723 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1043605723 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1315102846 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1315102846 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1315102846 SNP."
    },
    {
        "instruction": "In which chromosome is RS1315102846 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1315102846 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1315102846 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1315102846 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1315102846 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1315102846 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1315102846 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503067 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503067 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503067 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503067 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503067 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503067 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503067 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503067 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503067 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503067 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS755984043 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS755984043 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS755984043 SNP."
    },
    {
        "instruction": "In which chromosome is RS755984043 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS755984043 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS755984043 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS755984043 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS755984043 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS755984043 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS755984043 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS556205552 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS556205552 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS556205552 SNP."
    },
    {
        "instruction": "In which chromosome is RS556205552 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS556205552 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS556205552 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS556205552 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS556205552 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS556205552 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS556205552 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS577749913 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS577749913 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS577749913 SNP."
    },
    {
        "instruction": "In which chromosome is RS577749913 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS577749913 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS577749913 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS577749913 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS577749913 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS577749913 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS577749913 SNP?",
        "output": "The resulting gene consequence is a 3 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1956840?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1956840. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1956840."
    },
    {
        "instruction": "In which chromosome is SNV1956840 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1956840?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1956840, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1956840?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1956840?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1956840?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1956840?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1975324?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1975324. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1975324."
    },
    {
        "instruction": "In which chromosome is SNV1975324 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1975324?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1975324, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1975324?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1975324?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1975324?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1975324?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1970978?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1970978. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1970978."
    },
    {
        "instruction": "In which chromosome is SNV1970978 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1970978?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1970978, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1970978?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1970978?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1970978?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1970978?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1900793?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1900793. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1900793."
    },
    {
        "instruction": "In which chromosome is SNV1900793 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1900793?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1900793, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1900793?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1900793?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1900793?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1900793?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1922275?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1922275. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1922275."
    },
    {
        "instruction": "In which chromosome is SNV1922275 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1922275?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1922275, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1922275?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1922275?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1922275?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1922275?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1919559?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1919559. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1919559."
    },
    {
        "instruction": "In which chromosome is SNV1919559 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1919559?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1919559, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1919559?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1919559?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1919559?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1919559?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1928951?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1928951. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1928951."
    },
    {
        "instruction": "In which chromosome is SNV1928951 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1928951?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1928951, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for SNV1928951?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1928951?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1928951?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1928951?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1925654?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1925654. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1925654."
    },
    {
        "instruction": "In which chromosome is SNV1925654 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1925654?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1925654, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1925654?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1925654?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1925654?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1925654?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1934129?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1934129. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1934129."
    },
    {
        "instruction": "In which chromosome is SNV1934129 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1934129?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1934129, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1934129?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1934129?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1934129?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1934129?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2016080?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2016080. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2016080."
    },
    {
        "instruction": "In which chromosome is SNV2016080 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2016080?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2016080, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2016080?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2016080?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2016080?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2016080?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2013404?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2013404. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2013404."
    },
    {
        "instruction": "In which chromosome is SNV2013404 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2013404?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2013404, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2013404?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2013404?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2013404?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2013404?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2031921?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2031921. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2031921."
    },
    {
        "instruction": "In which chromosome is SNV2031921 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2031921?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2031921, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2031921?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2031921?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2031921?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2031921?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2030510?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2030510. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2030510."
    },
    {
        "instruction": "In which chromosome is SNV2030510 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2030510?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2030510, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2030510?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2030510?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2030510?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2030510?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2035731?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2035731. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2035731."
    },
    {
        "instruction": "In which chromosome is SNV2035731 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2035731?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2035731, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2035731?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2035731?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2035731?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2035731?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2044331?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2044331. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2044331."
    },
    {
        "instruction": "In which chromosome is SNV2044331 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2044331?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2044331, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2044331?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2044331?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2044331?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2044331?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2069570?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2069570. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2069570."
    },
    {
        "instruction": "In which chromosome is SNV2069570 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2069570?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2069570, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2069570?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2069570?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2069570?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2069570?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2070535?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2070535. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2070535."
    },
    {
        "instruction": "In which chromosome is SNV2070535 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2070535?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2070535, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2070535?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2070535?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2070535?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2070535?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2081112?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2081112. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2081112."
    },
    {
        "instruction": "In which chromosome is SNV2081112 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2081112?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2081112, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2081112?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2081112?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2081112?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2081112?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2084097?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2084097. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2084097."
    },
    {
        "instruction": "In which chromosome is SNV2084097 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2084097?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2084097, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2084097?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2084097?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2084097?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2084097?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2079026?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2079026. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2079026."
    },
    {
        "instruction": "In which chromosome is SNV2079026 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2079026?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2079026, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2079026?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2079026?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2079026?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2079026?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2072652?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2072652. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2072652."
    },
    {
        "instruction": "In which chromosome is SNV2072652 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2072652?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2072652, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2072652?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2072652?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2072652?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2072652?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2082070?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2082070. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2082070."
    },
    {
        "instruction": "In which chromosome is SNV2082070 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2082070?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2082070, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2082070?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2082070?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2082070?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2082070?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2082723?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2082723. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2082723."
    },
    {
        "instruction": "In which chromosome is SNV2082723 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2082723?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2082723, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2082723?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2082723?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2082723?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2082723?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2081422?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2081422. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2081422."
    },
    {
        "instruction": "In which chromosome is SNV2081422 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2081422?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2081422, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2081422?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2081422?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2081422?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2081422?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2090334?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2090334. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2090334."
    },
    {
        "instruction": "In which chromosome is SNV2090334 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2090334?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2090334, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2090334?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2090334?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2090334?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2090334?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2085973?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2085973. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2085973."
    },
    {
        "instruction": "In which chromosome is SNV2085973 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2085973?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2085973, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2085973?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2085973?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2085973?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2085973?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2095640?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2095640. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2095640."
    },
    {
        "instruction": "In which chromosome is SNV2095640 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2095640?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2095640, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2095640?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2095640?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2095640?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2095640?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2105746?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2105746. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2105746."
    },
    {
        "instruction": "In which chromosome is SNV2105746 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2105746?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2105746, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2105746?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2105746?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2105746?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2105746?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2112504?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2112504. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2112504."
    },
    {
        "instruction": "In which chromosome is SNV2112504 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2112504?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2112504, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2112504?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2112504?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2112504?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2112504?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2148166?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2148166. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2148166."
    },
    {
        "instruction": "In which chromosome is SNV2148166 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2148166?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2148166, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2148166?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2148166?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2148166?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2148166?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2165529?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2165529. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2165529."
    },
    {
        "instruction": "In which chromosome is SNV2165529 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2165529?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2165529, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2165529?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2165529?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2165529?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2165529?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2145853?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2145853. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2145853."
    },
    {
        "instruction": "In which chromosome is SNV2145853 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2145853?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2145853, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2145853?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2145853?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2145853?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2145853?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2177203?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2177203. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2177203."
    },
    {
        "instruction": "In which chromosome is SNV2177203 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2177203?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2177203, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2177203?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2177203?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2177203?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2177203?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2178788?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2178788. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2178788."
    },
    {
        "instruction": "In which chromosome is SNV2178788 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2178788?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2178788, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2178788?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2178788?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2178788?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2178788?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2191791?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2191791. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2191791."
    },
    {
        "instruction": "In which chromosome is SNV2191791 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2191791?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2191791, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2191791?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2191791?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2191791?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2191791?",
        "output": "The resulting gene consequence is a stop lost."
    },
    {
        "instruction": "Which condition is asociated with SNV2188404?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2188404. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2188404."
    },
    {
        "instruction": "In which chromosome is SNV2188404 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2188404?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2188404, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2188404?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2188404?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2188404?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2188404?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2171945?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2171945. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2171945."
    },
    {
        "instruction": "In which chromosome is SNV2171945 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2171945?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2171945, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2171945?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2171945?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2171945?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2171945?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1875071?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1875071. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1875071."
    },
    {
        "instruction": "In which chromosome is SNV1875071 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1875071?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1875071, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1875071?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1875071?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1875071?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1875071?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1879599?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1879599. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1879599."
    },
    {
        "instruction": "In which chromosome is SNV1879599 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1879599?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1879599, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1879599?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1879599?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1879599?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1879599?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1889203?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1889203. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1889203."
    },
    {
        "instruction": "In which chromosome is SNV1889203 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1889203?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1889203, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1889203?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1889203?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1889203?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1889203?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1893812?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1893812. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1893812."
    },
    {
        "instruction": "In which chromosome is SNV1893812 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1893812?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1893812, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1893812?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1893812?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1893812?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1893812?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1883694?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1883694. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1883694."
    },
    {
        "instruction": "In which chromosome is SNV1883694 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1883694?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1883694, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1883694?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1883694?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1883694?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1883694?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1796421?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1796421. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1796421."
    },
    {
        "instruction": "In which chromosome is SNV1796421 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1796421?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1796421, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1796421?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1796421?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1796421?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1796421?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1826856?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1826856. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1826856."
    },
    {
        "instruction": "In which chromosome is SNV1826856 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1826856?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1826856, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1826856?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1826856?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1826856?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1826856?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1832944?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1832944. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1832944."
    },
    {
        "instruction": "In which chromosome is SNV1832944 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1832944?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1832944, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1832944?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1832944?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1832944?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1832944?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1838585?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1838585. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1838585."
    },
    {
        "instruction": "In which chromosome is SNV1838585 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1838585?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1838585, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1838585?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1838585?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1838585?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1838585?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1842874?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1842874. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1842874."
    },
    {
        "instruction": "In which chromosome is SNV1842874 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1842874?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1842874, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1842874?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1842874?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1842874?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1842874?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1812724?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1812724. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1812724."
    },
    {
        "instruction": "In which chromosome is SNV1812724 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1812724?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1812724, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1812724?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1812724?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1812724?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1812724?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1841476?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1841476. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1841476."
    },
    {
        "instruction": "In which chromosome is SNV1841476 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1841476?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1841476, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1841476?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1841476?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1841476?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1841476?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1841006?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1841006. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1841006."
    },
    {
        "instruction": "In which chromosome is SNV1841006 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1841006?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1841006, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1841006?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1841006?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1841006?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1841006?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1841853?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1841853. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1841853."
    },
    {
        "instruction": "In which chromosome is SNV1841853 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1841853?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1841853, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1841853?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1841853?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1841853?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1841853?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1845986?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1845986. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1845986."
    },
    {
        "instruction": "In which chromosome is SNV1845986 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1845986?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1845986, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1845986?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1845986?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1845986?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1845986?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1804107?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1804107. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1804107."
    },
    {
        "instruction": "In which chromosome is SNV1804107 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1804107?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1804107, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1804107?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1804107?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1804107?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1804107?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1833115?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1833115. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1833115."
    },
    {
        "instruction": "In which chromosome is SNV1833115 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1833115?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1833115, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1833115?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1833115?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1833115?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1833115?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS121913301 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913301 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913301 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913301 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913301 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS121913301 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS121913301 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913301 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913301 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913301 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587776787 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776787 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776787 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776787 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776787 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776787 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776787 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776787 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776787 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776787 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS556201144 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS556201144 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS556201144 SNP."
    },
    {
        "instruction": "In which chromosome is RS556201144 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS556201144 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS556201144 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS556201144 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS556201144 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS556201144 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS556201144 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS761068783 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761068783 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761068783 SNP."
    },
    {
        "instruction": "In which chromosome is RS761068783 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761068783 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761068783 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS761068783 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761068783 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761068783 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761068783 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503093 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503093 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503093 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503093 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503093 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503093 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1060503093 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503093 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503093 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503093 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS147754935 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS147754935 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS147754935 SNP."
    },
    {
        "instruction": "In which chromosome is RS147754935 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS147754935 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS147754935 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS147754935 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS147754935 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS147754935 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS147754935 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS181988132 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS181988132 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS181988132 SNP."
    },
    {
        "instruction": "In which chromosome is RS181988132 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS181988132 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS181988132 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS181988132 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS181988132 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS181988132 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS181988132 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778641 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778641 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778641 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778641 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778641 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778641 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS587778641 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778641 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778641 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778641 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS138637932 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS138637932 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS138637932 SNP."
    },
    {
        "instruction": "In which chromosome is RS138637932 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS138637932 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS138637932 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS138637932 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS138637932 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS138637932 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS138637932 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1270702085 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1270702085 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1270702085 SNP."
    },
    {
        "instruction": "In which chromosome is RS1270702085 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1270702085 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1270702085 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1270702085 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1270702085 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1270702085 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1270702085 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS138574644 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS138574644 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS138574644 SNP."
    },
    {
        "instruction": "In which chromosome is RS138574644 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS138574644 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS138574644 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS138574644 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS138574644 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS138574644 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS138574644 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS775195256 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775195256 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775195256 SNP."
    },
    {
        "instruction": "In which chromosome is RS775195256 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775195256 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775195256 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS775195256 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775195256 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775195256 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775195256 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1295589257 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1295589257 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1295589257 SNP."
    },
    {
        "instruction": "In which chromosome is RS1295589257 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1295589257 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1295589257 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1295589257 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1295589257 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1295589257 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1295589257 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS750094760 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750094760 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750094760 SNP."
    },
    {
        "instruction": "In which chromosome is RS750094760 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750094760 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750094760 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS750094760 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750094760 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750094760 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750094760 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778848 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778848 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778848 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778848 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778848 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778848 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778848 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778848 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778848 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778848 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566187849 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566187849 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566187849 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566187849 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566187849 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566187849 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1566187849 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566187849 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566187849 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566187849 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS200674097 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200674097 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200674097 SNP."
    },
    {
        "instruction": "In which chromosome is RS200674097 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200674097 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200674097 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS200674097 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200674097 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200674097 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200674097 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS976503237 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS976503237 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS976503237 SNP."
    },
    {
        "instruction": "In which chromosome is RS976503237 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS976503237 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS976503237 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS976503237 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS976503237 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS976503237 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS976503237 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1295421967 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1295421967 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1295421967 SNP."
    },
    {
        "instruction": "In which chromosome is RS1295421967 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1295421967 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1295421967 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1295421967 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1295421967 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1295421967 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1295421967 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS375597447 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS375597447 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS375597447 SNP."
    },
    {
        "instruction": "In which chromosome is RS375597447 SNP located?",
        "output": "It is located in the chromosome 1."
    },
    {
        "instruction": "Which methods support the evidence found for the RS375597447 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS375597447 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS375597447 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS375597447 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS375597447 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS375597447 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1258210045 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1258210045 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1258210045 SNP."
    },
    {
        "instruction": "In which chromosome is RS1258210045 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1258210045 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1258210045 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1258210045 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1258210045 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1258210045 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1258210045 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593445228 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593445228 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593445228 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593445228 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593445228 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593445228 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593445228 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593445228 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593445228 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593445228 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1482284498 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1482284498 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1482284498 SNP."
    },
    {
        "instruction": "In which chromosome is RS1482284498 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1482284498 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1482284498 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS1482284498 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1482284498 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1482284498 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1482284498 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1472724809 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1472724809 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1472724809 SNP."
    },
    {
        "instruction": "In which chromosome is RS1472724809 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1472724809 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1472724809 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1472724809 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1472724809 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1472724809 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1472724809 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS121913300 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS121913300 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS121913300 SNP."
    },
    {
        "instruction": "In which chromosome is RS121913300 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS121913300 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS121913300 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS121913300 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS121913300 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS121913300 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS121913300 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS757818801 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS757818801 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS757818801 SNP."
    },
    {
        "instruction": "In which chromosome is RS757818801 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS757818801 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS757818801 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS757818801 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS757818801 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS757818801 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS757818801 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778823 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778823 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778823 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778823 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778823 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778823 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS373623059 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS373623059 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS373623059 SNP."
    },
    {
        "instruction": "In which chromosome is RS373623059 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS373623059 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS373623059 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS373623059 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS373623059 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS373623059 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS373623059 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS780006952 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780006952 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780006952 SNP."
    },
    {
        "instruction": "In which chromosome is RS780006952 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780006952 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780006952 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS780006952 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS780006952 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780006952 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780006952 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS371805499 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371805499 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371805499 SNP."
    },
    {
        "instruction": "In which chromosome is RS371805499 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371805499 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371805499 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS371805499 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371805499 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371805499 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371805499 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS777340111 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS777340111 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS777340111 SNP."
    },
    {
        "instruction": "In which chromosome is RS777340111 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS777340111 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS777340111 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS777340111 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS777340111 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS777340111 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS777340111 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS762380973 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762380973 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762380973 SNP."
    },
    {
        "instruction": "In which chromosome is RS762380973 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762380973 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762380973 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS762380973 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762380973 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762380973 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762380973 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS142620145 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS142620145 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS142620145 SNP."
    },
    {
        "instruction": "In which chromosome is RS142620145 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS142620145 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS142620145 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS142620145 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS142620145 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS142620145 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS142620145 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS752342013 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS752342013 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS752342013 SNP."
    },
    {
        "instruction": "In which chromosome is RS752342013 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS752342013 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS752342013 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS752342013 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS752342013 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS752342013 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS752342013 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952680873 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952680873 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952680873 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952680873 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952680873 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952680873 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952680873 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952680873 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952680873 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952680873 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778870 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778870 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778870 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778870 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778870 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778870 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS587778870 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778870 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778870 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778870 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1173330253 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1173330253 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1173330253 SNP."
    },
    {
        "instruction": "In which chromosome is RS1173330253 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1173330253 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1173330253 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1173330253 SNP?",
        "output": "The variation length is 6 base pairs."
    },
    {
        "instruction": "What is the origin for RS1173330253 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1173330253 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1173330253 SNP?",
        "output": "The resulting gene consequence is a inframe_insertion."
    },
    {
        "instruction": "Which condition is asociated with RS750578651 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750578651 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750578651 SNP."
    },
    {
        "instruction": "In which chromosome is RS750578651 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750578651 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750578651 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS750578651 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750578651 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750578651 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750578651 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS938094455 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS938094455 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS938094455 SNP."
    },
    {
        "instruction": "In which chromosome is RS938094455 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS938094455 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS938094455 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS938094455 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS938094455 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS938094455 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS938094455 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS912203557 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS912203557 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS912203557 SNP."
    },
    {
        "instruction": "In which chromosome is RS912203557 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS912203557 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS912203557 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS912203557 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS912203557 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS912203557 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS912203557 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949383921 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949383921 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949383921 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949383921 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949383921 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949383921 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949383921 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949383921 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949383921 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949383921 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS925399787 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS925399787 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS925399787 SNP."
    },
    {
        "instruction": "In which chromosome is RS925399787 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS925399787 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS925399787 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS925399787 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS925399787 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS925399787 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS925399787 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948523564 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948523564 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948523564 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948523564 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948523564 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948523564 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1948523564 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948523564 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948523564 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948523564 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS761257231 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS761257231 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS761257231 SNP."
    },
    {
        "instruction": "In which chromosome is RS761257231 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS761257231 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS761257231 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS761257231 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS761257231 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS761257231 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS761257231 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS770277291 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS770277291 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS770277291 SNP."
    },
    {
        "instruction": "In which chromosome is RS770277291 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS770277291 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS770277291 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS770277291 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS770277291 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS770277291 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS770277291 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1353683992 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1353683992 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1353683992 SNP."
    },
    {
        "instruction": "In which chromosome is RS1353683992 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1353683992 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1353683992 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1353683992 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1353683992 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1353683992 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1353683992 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949432512 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949432512 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949432512 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949432512 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949432512 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949432512 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949432512 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949432512 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949432512 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949432512 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952727001 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952727001 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952727001 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952727001 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952727001 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952727001 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952727001 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952727001 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952727001 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952727001 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952522583 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952522583 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952522583 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952522583 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952522583 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952522583 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952522583 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952522583 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952522583 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952522583 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952626050 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952626050 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952626050 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952626050 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952626050 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952626050 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952626050 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952626050 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952626050 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952626050 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949484533 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949484533 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949484533 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949484533 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949484533 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949484533 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1949484533 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949484533 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949484533 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949484533 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1048350?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1048350. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1048350."
    },
    {
        "instruction": "In which chromosome is SNV1048350 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1048350?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1048350, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1048350?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1048350?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1048350?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1048350?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1080097?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1080097. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1080097."
    },
    {
        "instruction": "In which chromosome is SNV1080097 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1080097?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1080097, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1080097?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1080097?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1080097?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1080097?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593453983 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593453983 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593453983 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593453983 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593453983 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593453983 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593453983 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593453983 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593453983 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593453983 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1101902?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1101902. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1101902."
    },
    {
        "instruction": "In which chromosome is SNV1101902 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1101902?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1101902, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1101902?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1101902?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1101902?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1101902?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123357?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123357. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123357."
    },
    {
        "instruction": "In which chromosome is SNV1123357 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123357?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123357, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123357?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123357?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123357?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123357?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1123371?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1123371. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1123371."
    },
    {
        "instruction": "In which chromosome is SNV1123371 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1123371?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1123371, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1123371?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1123371?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1123371?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1123371?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983592?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983592. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983592."
    },
    {
        "instruction": "In which chromosome is SNV983592 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983592?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV983592, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for SNV983592?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983592?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983592?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983592?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1374592?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1374592. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1374592."
    },
    {
        "instruction": "In which chromosome is SNV1374592 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1374592?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1374592, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1374592?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1374592?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1374592?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1374592?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1387712?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1387712. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1387712."
    },
    {
        "instruction": "In which chromosome is SNV1387712 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1387712?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1387712, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1387712?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1387712?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1387712?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1387712?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1504161?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1504161. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1504161."
    },
    {
        "instruction": "In which chromosome is SNV1504161 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1504161?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1504161, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1504161?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1504161?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1504161?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1504161?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1468890?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1468890. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1468890."
    },
    {
        "instruction": "In which chromosome is SNV1468890 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1468890?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1468890, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1468890?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1468890?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1468890?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1468890?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1443065?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1443065. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1443065."
    },
    {
        "instruction": "In which chromosome is SNV1443065 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1443065?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1443065, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1443065?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1443065?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1443065?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1443065?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1557591?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1557591. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1557591."
    },
    {
        "instruction": "In which chromosome is SNV1557591 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1557591?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1557591, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1557591?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1557591?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1557591?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1557591?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1624645?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1624645. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1624645."
    },
    {
        "instruction": "In which chromosome is SNV1624645 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1624645?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1624645, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1624645?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1624645?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1624645?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1624645?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2104293?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2104293. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2104293."
    },
    {
        "instruction": "In which chromosome is SNV2104293 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2104293?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2104293, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2104293?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2104293?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2104293?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2104293?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2117799?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2117799. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2117799."
    },
    {
        "instruction": "In which chromosome is SNV2117799 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2117799?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2117799, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2117799?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2117799?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2117799?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2117799?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2145235?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2145235. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2145235."
    },
    {
        "instruction": "In which chromosome is SNV2145235 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2145235?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2145235, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV2145235?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2145235?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2145235?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2145235?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2175343?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2175343. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2175343."
    },
    {
        "instruction": "In which chromosome is SNV2175343 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2175343?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2175343, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV2175343?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2175343?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2175343?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2175343?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1878516?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1878516. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1878516."
    },
    {
        "instruction": "In which chromosome is SNV1878516 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1878516?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1878516, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1878516?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1878516?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1878516?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1878516?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1872693?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1872693. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1872693."
    },
    {
        "instruction": "In which chromosome is SNV1872693 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1872693?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1872693, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1872693?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1872693?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1872693?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1872693?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS201697122 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201697122 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201697122 SNP."
    },
    {
        "instruction": "In which chromosome is RS201697122 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201697122 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201697122 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS201697122 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201697122 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201697122 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201697122 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS762805947 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762805947 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762805947 SNP."
    },
    {
        "instruction": "In which chromosome is RS762805947 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762805947 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762805947 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS762805947 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762805947 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762805947 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762805947 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092895 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092895 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092895 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092895 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092895 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092895 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS3092895 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092895 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092895 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092895 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS748094394 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS748094394 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS748094394 SNP."
    },
    {
        "instruction": "In which chromosome is RS748094394 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS748094394 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS748094394 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS748094394 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS748094394 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS748094394 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS748094394 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593412219 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593412219 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593412219 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593412219 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593412219 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593412219 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593412219 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593412219 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593412219 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593412219 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS759594127 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS759594127 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS759594127 SNP."
    },
    {
        "instruction": "In which chromosome is RS759594127 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS759594127 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS759594127 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS759594127 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS759594127 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS759594127 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS759594127 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS4151610 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151610 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151610 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151610 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151610 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151610 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS4151610 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151610 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151610 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151610 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with DEL1451448?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsDEL1451448. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/DEL1451448."
    },
    {
        "instruction": "In which chromosome is DEL1451448 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the DEL1451448?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of DEL1451448, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for DEL1451448?",
        "output": "The variation length is 35 base pairs."
    },
    {
        "instruction": "What is the origin for DEL1451448?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for DEL1451448?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for DEL1451448?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS1414284893 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1414284893 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1414284893 SNP."
    },
    {
        "instruction": "In which chromosome is RS1414284893 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1414284893 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1414284893 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1414284893 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1414284893 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1414284893 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1414284893 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1709782?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1709782. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1709782."
    },
    {
        "instruction": "In which chromosome is SNV1709782 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1709782?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1709782, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for SNV1709782?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1709782?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1709782?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1709782?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS866638680 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS866638680 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS866638680 SNP."
    },
    {
        "instruction": "In which chromosome is RS866638680 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS866638680 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS866638680 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS866638680 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS866638680 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS866638680 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS866638680 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS146434474 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS146434474 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS146434474 SNP."
    },
    {
        "instruction": "In which chromosome is RS146434474 SNP located?",
        "output": "It is located in the chromosome 16."
    },
    {
        "instruction": "Which methods support the evidence found for the RS146434474 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS146434474 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS146434474 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS146434474 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS146434474 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS146434474 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690852 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690852 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690852 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690852 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690852 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690852 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690852 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690852 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690852 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690852 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778632 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778632 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778632 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778632 SNP located?",
        "output": "It is located in the chromosome 9."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778632 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778632 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS587778632 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778632 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778632 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778632 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS764137082 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS764137082 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS764137082 SNP."
    },
    {
        "instruction": "In which chromosome is RS764137082 SNP located?",
        "output": "It is located in the chromosome 9."
    },
    {
        "instruction": "Which methods support the evidence found for the RS764137082 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS764137082 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS764137082 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS764137082 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS764137082 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS764137082 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS962982192 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS962982192 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS962982192 SNP."
    },
    {
        "instruction": "In which chromosome is RS962982192 SNP located?",
        "output": "It is located in the chromosome 9."
    },
    {
        "instruction": "Which methods support the evidence found for the RS962982192 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS962982192 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS962982192 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS962982192 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS962982192 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS962982192 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186125 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186125 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186125 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186125 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186125 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186125 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566186125 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186125 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186125 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186125 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS751799266 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS751799266 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS751799266 SNP."
    },
    {
        "instruction": "In which chromosome is RS751799266 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS751799266 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS751799266 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS751799266 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS751799266 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS751799266 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS751799266 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS367668687 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS367668687 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS367668687 SNP."
    },
    {
        "instruction": "In which chromosome is RS367668687 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS367668687 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS367668687 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS367668687 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS367668687 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS367668687 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS367668687 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948522792 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948522792 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948522792 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948522792 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948522792 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1948522792 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948522792 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948522792 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948522792 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948522792 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS368413787 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS368413787 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS368413787 SNP."
    },
    {
        "instruction": "In which chromosome is RS368413787 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS368413787 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS368413787 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS368413787 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS368413787 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS368413787 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS368413787 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566240909 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566240909 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566240909 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566240909 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566240909 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566240909 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566240909 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566240909 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566240909 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566240909 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with SNV1852339?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1852339. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1852339."
    },
    {
        "instruction": "In which chromosome is SNV1852339 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1852339?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1852339, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for SNV1852339?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1852339?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1852339?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1852339?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776779 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776779 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776779 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776779 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776779 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776779 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776779 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776779 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776779 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776779 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776780 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776780 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776780 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776780 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776780 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776780 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776780 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776780 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776780 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776780 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776782 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776782 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776782 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776782 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776782 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776782 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776782 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776782 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776782 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776782 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776786 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776786 SNP?",
        "output": "Associated methods are: literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776786 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776786 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776786 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776789 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776789 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776789 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776789 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776789 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776789 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776789 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776789 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776789 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776789 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778867 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778867 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778867 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778867 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778867 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778867 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778867 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778867 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778867 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778867 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778860 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778860 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778860 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778860 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778860 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778860 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778860 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778860 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778860 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778860 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778838 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778838 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778838 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778838 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778838 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778838 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778838 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778838 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778838 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778838 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778850 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778850 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778850 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778850 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778850 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778850 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778850 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778850 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778850 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778850 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778839 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778839 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778839 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778839 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778839 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778839 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778839 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778839 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778839 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778839 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776782 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776782 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776782 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776782 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776782 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587776782 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776782 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776782 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776782 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776782 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776783 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776783 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776783 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776783 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776783 SNP?",
        "output": "Associated methods are: research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776783 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS587776783 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776783 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776783 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776783 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778831 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778831 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778831 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778831 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778831 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778831 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778831 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778831 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778831 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778831 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778846 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778846 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778846 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778846 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778846 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778846 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778846 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778846 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778846 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778846 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778846 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778846 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778846 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778846 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778846 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778846 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778846 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778846 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778846 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778846 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778857 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778857 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778857 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778857 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778857 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778857 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778857 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778857 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778857 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778857 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS200844292 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200844292 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200844292 SNP."
    },
    {
        "instruction": "In which chromosome is RS200844292 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200844292 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200844292 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS200844292 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200844292 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200844292 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200844292 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092904 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092904 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092904 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092904 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092904 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092904 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS3092904 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092904 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092904 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092904 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS200658795 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS200658795 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS200658795 SNP."
    },
    {
        "instruction": "In which chromosome is RS200658795 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS200658795 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS200658795 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS200658795 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS200658795 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS200658795 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS200658795 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092881 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092881 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092881 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092881 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092881 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092881 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS3092881 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092881 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092881 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092881 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503087 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503087 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503087 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503087 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503087 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503087 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503087 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503087 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503087 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503087 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503074 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503074 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503074 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503074 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503074 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503074 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503074 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503074 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503074 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503074 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555294636 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555294636 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555294636 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555294636 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555294636 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555294636 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555294636 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555294636 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555294636 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555294636 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690860 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690860 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690860 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690860 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690860 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690860 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690860 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690860 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690860 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690860 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286503 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286503 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286503 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286503 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286503 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286503 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286503 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286503 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286503 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286503 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286568 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286568 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286568 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286568 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286568 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286568 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286568 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286568 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286568 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286568 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1461382798 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1461382798 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1461382798 SNP."
    },
    {
        "instruction": "In which chromosome is RS1461382798 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1461382798 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1461382798 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1461382798 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1461382798 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1461382798 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1461382798 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS886038280 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886038280 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886038280 SNP."
    },
    {
        "instruction": "In which chromosome is RS886038280 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886038280 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS886038280 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS886038280 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS886038280 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS886038280 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886038280 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778850 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778850 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778850 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778850 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778850 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778850 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778850 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778850 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778850 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778850 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555286568 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555286568 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555286568 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555286568 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555286568 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555286568 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1555286568 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555286568 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555286568 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555286568 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566235515 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566235515 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566235515 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566235515 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566235515 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566235515 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS1566235515 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566235515 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566235515 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566235515 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690860 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690860 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690860 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690860 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690860 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690860 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690860 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690860 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690860 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690860 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566187856 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566187856 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566187856 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566187856 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566187856 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566187856 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566187856 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566187856 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566187856 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566187856 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690882 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690882 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690882 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690882 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690882 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690882 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690882 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690882 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690882 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690882 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1258442224 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1258442224 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1258442224 SNP."
    },
    {
        "instruction": "In which chromosome is RS1258442224 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1258442224 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1258442224 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1258442224 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1258442224 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1258442224 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1258442224 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566186836 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566186836 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566186836 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566186836 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566186836 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566186836 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic/Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566186836 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566186836 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566186836 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566186836 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593529868 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593529868 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593529868 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593529868 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593529868 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593529868 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593529868 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593529868 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593529868 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593529868 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1566235515 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1566235515 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1566235515 SNP."
    },
    {
        "instruction": "In which chromosome is RS1566235515 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1566235515 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1566235515 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1566235515 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1566235515 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1566235515 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1566235515 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503087 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503087 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503087 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503087 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503087 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503087 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503087 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503087 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503087 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503087 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593531874 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593531874 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593531874 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593531874 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593531874 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593531874 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1593531874 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593531874 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593531874 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593531874 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS183898408 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS183898408 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS183898408 SNP."
    },
    {
        "instruction": "In which chromosome is RS183898408 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS183898408 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS183898408 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS183898408 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS183898408 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS183898408 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS183898408 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593453973 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593453973 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593453973 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593453973 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593453973 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593453973 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593453973 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593453973 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593453973 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593453973 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952680837 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952680837 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952680837 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952680837 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952680837 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952680837 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952680837 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952680837 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952680837 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952680837 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949420231 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949420231 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949420231 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949420231 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949420231 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949420231 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949420231 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949420231 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949420231 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949420231 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949432057 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949432057 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949432057 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949432057 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949432057 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949432057 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949432057 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949432057 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949432057 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949432057 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949360306 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949360306 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949360306 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949360306 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949360306 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949360306 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949360306 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949360306 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949360306 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949360306 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952654925 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952654925 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952654925 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952654925 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952654925 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952654925 SNP, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952654925 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952654925 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952654925 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952654925 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949383286 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949383286 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949383286 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949383286 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949383286 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949383286 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949383286 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949383286 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949383286 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949383286 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949360306 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949360306 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949360306 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949360306 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949360306 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949360306 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949360306 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949360306 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949360306 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949360306 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776780 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776780 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776780 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776780 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776780 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587776780 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776780 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776780 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776780 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776780 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593538130 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593538130 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593538130 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593538130 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593538130 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593538130 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593538130 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593538130 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593538130 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593538130 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952480014 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952480014 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952480014 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952480014 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952480014 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952480014 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1952480014 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952480014 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952480014 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952480014 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060503074 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060503074 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060503074 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060503074 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060503074 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060503074 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1060503074 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060503074 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060503074 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060503074 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690902 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690902 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690902 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690902 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690902 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690902 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690902 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690902 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690902 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690902 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1948523741 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1948523741 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1948523741 SNP."
    },
    {
        "instruction": "In which chromosome is RS1948523741 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1948523741 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS1948523741 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1948523741 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1948523741 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS1948523741 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1948523741 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1949360306 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1949360306 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1949360306 SNP."
    },
    {
        "instruction": "In which chromosome is RS1949360306 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1949360306 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1949360306 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1949360306 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1949360306 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1949360306 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1949360306 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952654925 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952654925 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952654925 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952654925 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952654925 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952654925 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952654925 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952654925 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952654925 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952654925 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1952624973 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1952624973 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1952624973 SNP."
    },
    {
        "instruction": "In which chromosome is RS1952624973 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1952624973 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1952624973 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1952624973 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1952624973 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1952624973 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1952624973 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062990?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062990. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062990."
    },
    {
        "instruction": "In which chromosome is SNV1062990 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062990?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062990, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062990?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062990?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062990?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062990?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690886 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690886 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690886 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690886 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690886 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690886 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690886 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690886 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690886 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690886 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062995?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062995. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062995."
    },
    {
        "instruction": "In which chromosome is SNV1062995 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062995?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062995, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062995?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062995?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062995?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062995?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062984?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062984. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062984."
    },
    {
        "instruction": "In which chromosome is SNV1062984 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062984?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062984, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062984?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062984?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062984?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062984?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1062989?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1062989. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1062989."
    },
    {
        "instruction": "In which chromosome is SNV1062989 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1062989?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1062989, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1062989?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1062989?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1062989?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1062989?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with RS794727199 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS794727199 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS794727199 SNP."
    },
    {
        "instruction": "In which chromosome is RS794727199 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS794727199 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS794727199 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS794727199 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS794727199 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS794727199 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS794727199 SNP?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1063000?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063000. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063000."
    },
    {
        "instruction": "In which chromosome is SNV1063000 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063000?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063000, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063000?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063000?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063000?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063000?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1063003?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063003. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063003."
    },
    {
        "instruction": "In which chromosome is SNV1063003 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063003?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063003, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063003?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063003?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063003?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063003?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1063010?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1063010. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1063010."
    },
    {
        "instruction": "In which chromosome is SNV1063010 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1063010?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1063010, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1063010?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1063010?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1063010?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1063010?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983593?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983593. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983593."
    },
    {
        "instruction": "In which chromosome is SNV983593 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983593?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV983593, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983593?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983593?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983593?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983593?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983600?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983600. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983600."
    },
    {
        "instruction": "In which chromosome is SNV983600 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983600?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV983600, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983600?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983600?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983600?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983600?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV983591?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV983591. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV983591."
    },
    {
        "instruction": "In which chromosome is SNV983591 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV983591?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV983591, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV983591?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV983591?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV983591?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV983591?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1166992?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1166992. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1166992."
    },
    {
        "instruction": "In which chromosome is SNV1166992 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1166992?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1166992, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1166992?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1166992?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1166992?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1166992?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1166996?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1166996. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1166996."
    },
    {
        "instruction": "In which chromosome is SNV1166996 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1166996?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1166996, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1166996?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1166996?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1166996?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1166996?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS3020646 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3020646 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3020646 SNP."
    },
    {
        "instruction": "In which chromosome is RS3020646 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3020646 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3020646 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS3020646 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3020646 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3020646 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3020646 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS198617 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS198617 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS198617 SNP."
    },
    {
        "instruction": "In which chromosome is RS198617 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS198617 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS198617 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS198617 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS198617 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS198617 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS198617 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690882 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690882 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690882 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690882 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690882 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690882 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690882 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690882 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690882 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690882 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690907 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690907 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690907 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690907 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690907 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690907 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690907 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690907 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690907 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690907 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1409060?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1409060. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1409060."
    },
    {
        "instruction": "In which chromosome is SNV1409060 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1409060?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1409060, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1409060?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1409060?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1409060?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1409060?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1415961?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1415961. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1415961."
    },
    {
        "instruction": "In which chromosome is SNV1415961 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1415961?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1415961, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1415961?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1415961?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1415961?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1415961?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1484857?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1484857. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1484857."
    },
    {
        "instruction": "In which chromosome is SNV1484857 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1484857?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1484857, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1484857?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1484857?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1484857?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1484857?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1400287?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1400287. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1400287."
    },
    {
        "instruction": "In which chromosome is SNV1400287 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1400287?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1400287, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1400287?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1400287?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1400287?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1400287?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1428780?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1428780. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1428780."
    },
    {
        "instruction": "In which chromosome is SNV1428780 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1428780?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1428780, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1428780?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1428780?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1428780?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1428780?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1501129?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1501129. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1501129."
    },
    {
        "instruction": "In which chromosome is SNV1501129 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1501129?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1501129, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1501129?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1501129?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1501129?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1501129?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1503449?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1503449. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1503449."
    },
    {
        "instruction": "In which chromosome is SNV1503449 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1503449?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1503449, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1503449?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1503449?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1503449?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1503449?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1428784?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1428784. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1428784."
    },
    {
        "instruction": "In which chromosome is SNV1428784 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1428784?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1428784, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1428784?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1428784?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1428784?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1428784?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1486041?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1486041. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1486041."
    },
    {
        "instruction": "In which chromosome is SNV1486041 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1486041?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1486041, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1486041?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1486041?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1486041?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1486041?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1691189?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1691189. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1691189."
    },
    {
        "instruction": "In which chromosome is SNV1691189 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1691189?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1691189, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1691189?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1691189?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1691189?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1691189?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1131690880 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1131690880 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1131690880 SNP."
    },
    {
        "instruction": "In which chromosome is RS1131690880 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1131690880 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1131690880 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1131690880 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1131690880 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1131690880 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1131690880 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776789 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776789 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776789 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776789 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776789 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587776789 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776789 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776789 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776789 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776789 SNP?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1918434?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1918434. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1918434."
    },
    {
        "instruction": "In which chromosome is SNV1918434 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1918434?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1918434, is it benign or pathogenic?",
        "output": "It is Likely pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1918434?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1918434?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1918434?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1918434?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV2056034?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV2056034. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV2056034."
    },
    {
        "instruction": "In which chromosome is SNV2056034 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV2056034?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV2056034, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV2056034?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV2056034?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV2056034?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV2056034?",
        "output": "The resulting gene consequence is a splice acceptor variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874620?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874620. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874620."
    },
    {
        "instruction": "In which chromosome is SNV1874620 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874620?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874620, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874620?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874620?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874620?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874620?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with SNV1874613?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV1874613. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV1874613."
    },
    {
        "instruction": "In which chromosome is SNV1874613 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV1874613?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV1874613, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV1874613?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV1874613?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for SNV1874613?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV1874613?",
        "output": "The resulting gene consequence is a splice donor variant."
    },
    {
        "instruction": "Which condition is asociated with RS1168863456 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1168863456 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1168863456 SNP."
    },
    {
        "instruction": "In which chromosome is RS1168863456 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1168863456 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1168863456 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS1168863456 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1168863456 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1168863456 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1168863456 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS896487590 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS896487590 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS896487590 SNP."
    },
    {
        "instruction": "In which chromosome is RS896487590 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS896487590 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS896487590 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS896487590 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS896487590 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS896487590 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS896487590 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS769696726 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS769696726 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS769696726 SNP."
    },
    {
        "instruction": "In which chromosome is RS769696726 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS769696726 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS769696726 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS769696726 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS769696726 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS769696726 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS769696726 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS387906521 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS387906521 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS387906521 SNP."
    },
    {
        "instruction": "In which chromosome is RS387906521 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS387906521 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS387906521 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS387906521 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS387906521 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS387906521 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "Which condition is asociated with RS137853294 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS137853294 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS137853294 SNP."
    },
    {
        "instruction": "In which chromosome is RS137853294 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS137853294 SNP?",
        "output": "Associated methods are: phenotyping only, research, clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS137853294 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS137853294 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS137853294 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS137853294 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS137853294 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS587776788 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587776788 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587776788 SNP."
    },
    {
        "instruction": "In which chromosome is RS587776788 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587776788 SNP?",
        "output": "Associated methods are: clinical testing, literature only."
    },
    {
        "instruction": "What is the clinical significance of RS587776788 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587776788 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS587776788 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587776788 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587776788 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with SNV132309?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV132309. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV132309."
    },
    {
        "instruction": "In which chromosome is SNV132309 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV132309?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of SNV132309, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV132309?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV132309?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for SNV132309?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV132309?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778836 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778836 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778836 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778836 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778836 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778836 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778836 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778836 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778836 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778836 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with SNV132312?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsSNV132312. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/SNV132312."
    },
    {
        "instruction": "In which chromosome is SNV132312 located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the SNV132312?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of SNV132312, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for SNV132312?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for SNV132312?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for SNV132312?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for SNV132312?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS587778837 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778837 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778837 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778837 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778837 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778837 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778837 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778837 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778837 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778837 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778851 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778851 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778851 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778851 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778851 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778851 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778851 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778851 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778851 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778851 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778825 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778825 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778825 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778825 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778825 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778825 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778825 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778825 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778825 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778825 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778841 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778841 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778841 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778841 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778841 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778841 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778841 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778841 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778841 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778841 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778854 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778854 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778854 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778854 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778854 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778854 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778854 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778854 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778854 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778854 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS886037649 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS886037649 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS886037649 SNP."
    },
    {
        "instruction": "In which chromosome is RS886037649 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS886037649 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS886037649 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS886037649 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS886037649 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS886037649 SNP?",
        "output": "The variation is a Indel."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS886037649 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778827 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778827 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778827 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778827 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778827 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778827 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778827 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778827 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778827 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778827 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778828 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778828 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778828 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778828 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778828 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778828 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778828 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778828 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778828 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778828 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778844 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778844 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778844 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778844 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778844 SNP?",
        "output": "Associated methods are: research."
    },
    {
        "instruction": "What is the clinical significance of RS587778844 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778844 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778844 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778844 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778844 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778829 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778829 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778829 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778829 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778829 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778829 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778829 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778829 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778829 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778829 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778830 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778830 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778830 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778830 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778830 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778830 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778830 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778830 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778830 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778830 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778832 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778832 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778832 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778832 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778832 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778832 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778832 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778832 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778832 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778832 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778840 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778840 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778840 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778840 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778840 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778840 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778840 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778840 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778840 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778840 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778862 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778862 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778862 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778862 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778862 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778862 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778862 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778862 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778862 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778862 SNP?",
        "output": "The resulting gene consequence is a frameshift variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778824 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778824 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778824 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778824 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778824 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778824 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS587778824 SNP?",
        "output": "The variation length is 2 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778824 SNP?",
        "output": "The origin is somatic."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778824 SNP?",
        "output": "The variation is a Duplication."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778824 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    },
    {
        "instruction": "Which condition is asociated with RS145310579 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS145310579 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS145310579 SNP."
    },
    {
        "instruction": "In which chromosome is RS145310579 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS145310579 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS145310579 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS145310579 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS145310579 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS145310579 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS145310579 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS187110786 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS187110786 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS187110786 SNP."
    },
    {
        "instruction": "In which chromosome is RS187110786 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS187110786 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS187110786 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS187110786 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS187110786 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS187110786 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS187110786 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS572454921 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS572454921 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS572454921 SNP."
    },
    {
        "instruction": "In which chromosome is RS572454921 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS572454921 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS572454921 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS572454921 SNP?",
        "output": "The variation length is 9 base pairs."
    },
    {
        "instruction": "What is the origin for RS572454921 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS572454921 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS572454921 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS4151624 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS4151624 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS4151624 SNP."
    },
    {
        "instruction": "In which chromosome is RS4151624 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS4151624 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS4151624 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS4151624 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS4151624 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS4151624 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS4151624 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS9535023 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS9535023 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS9535023 SNP."
    },
    {
        "instruction": "In which chromosome is RS9535023 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS9535023 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS9535023 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS9535023 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS9535023 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS9535023 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS9535023 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS753117180 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS753117180 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS753117180 SNP."
    },
    {
        "instruction": "In which chromosome is RS753117180 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS753117180 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS753117180 SNP, is it benign or pathogenic?",
        "output": "It is Conflicting interpretations of pathogenicity."
    },
    {
        "instruction": "How long is the variation length for RS753117180 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS753117180 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS753117180 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS753117180 SNP?",
        "output": "The resulting gene consequence is a 5 prime UTR variant."
    },
    {
        "instruction": "Which condition is asociated with RS375751988 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS375751988 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS375751988 SNP."
    },
    {
        "instruction": "In which chromosome is RS375751988 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS375751988 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS375751988 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS375751988 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS375751988 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS375751988 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS375751988 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS587778823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS587778823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS587778823 SNP."
    },
    {
        "instruction": "In which chromosome is RS587778823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS587778823 SNP?",
        "output": "Associated methods are: research, clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS587778823 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS587778823 SNP?",
        "output": "The variation length is 3 base pairs."
    },
    {
        "instruction": "What is the origin for RS587778823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS587778823 SNP?",
        "output": "The variation is a Microsatellite."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS587778823 SNP?",
        "output": "The resulting gene consequence is a inframe_deletion."
    },
    {
        "instruction": "Which condition is asociated with RS150115447 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS150115447 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS150115447 SNP."
    },
    {
        "instruction": "In which chromosome is RS150115447 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS150115447 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS150115447 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS150115447 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS150115447 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS150115447 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS150115447 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS864622373 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS864622373 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS864622373 SNP."
    },
    {
        "instruction": "In which chromosome is RS864622373 SNP located?",
        "output": "It is located in the chromosome 17."
    },
    {
        "instruction": "Which methods support the evidence found for the RS864622373 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS864622373 SNP, is it benign or pathogenic?",
        "output": "It is Uncertain significance."
    },
    {
        "instruction": "How long is the variation length for RS864622373 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS864622373 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS864622373 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS864622373 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS143105337 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS143105337 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS143105337 SNP."
    },
    {
        "instruction": "In which chromosome is RS143105337 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS143105337 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS143105337 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS143105337 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS143105337 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS143105337 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS143105337 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092902 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092902 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092902 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092902 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092902 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092902 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS3092902 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092902 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092902 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092902 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS373601944 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS373601944 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS373601944 SNP."
    },
    {
        "instruction": "In which chromosome is RS373601944 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS373601944 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS373601944 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS373601944 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS373601944 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS373601944 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS373601944 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS142509759 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS142509759 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS142509759 SNP."
    },
    {
        "instruction": "In which chromosome is RS142509759 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS142509759 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS142509759 SNP, is it benign or pathogenic?",
        "output": "It is Benign/Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS142509759 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS142509759 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS142509759 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS142509759 SNP?",
        "output": "The resulting gene consequence is a missense variant."
    },
    {
        "instruction": "Which condition is asociated with RS148327780 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS148327780 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS148327780 SNP."
    },
    {
        "instruction": "In which chromosome is RS148327780 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS148327780 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS148327780 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS148327780 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS148327780 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS148327780 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS148327780 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593454066 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593454066 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593454066 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593454066 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593454066 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593454066 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593454066 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593454066 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593454066 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593454066 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593435736 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593435736 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593435736 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593435736 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593435736 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593435736 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593435736 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593435736 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593435736 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593435736 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS746662122 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS746662122 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS746662122 SNP."
    },
    {
        "instruction": "In which chromosome is RS746662122 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS746662122 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS746662122 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS746662122 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS746662122 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS746662122 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS746662122 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1419123438 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1419123438 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1419123438 SNP."
    },
    {
        "instruction": "In which chromosome is RS1419123438 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1419123438 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1419123438 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1419123438 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1419123438 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1419123438 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1419123438 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1039235140 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1039235140 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1039235140 SNP."
    },
    {
        "instruction": "In which chromosome is RS1039235140 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1039235140 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1039235140 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1039235140 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1039235140 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1039235140 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1039235140 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1411090163 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1411090163 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1411090163 SNP."
    },
    {
        "instruction": "In which chromosome is RS1411090163 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1411090163 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1411090163 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1411090163 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1411090163 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1411090163 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1411090163 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060504826 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060504826 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060504826 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060504826 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060504826 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060504826 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1060504826 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060504826 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060504826 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060504826 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593531868 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593531868 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593531868 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593531868 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593531868 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593531868 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593531868 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593531868 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593531868 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593531868 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1316896547 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1316896547 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1316896547 SNP."
    },
    {
        "instruction": "In which chromosome is RS1316896547 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1316896547 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1316896547 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1316896547 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1316896547 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1316896547 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1316896547 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS201020747 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS201020747 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS201020747 SNP."
    },
    {
        "instruction": "In which chromosome is RS201020747 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS201020747 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS201020747 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS201020747 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS201020747 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS201020747 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS201020747 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593411999 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593411999 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593411999 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593411999 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593411999 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593411999 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593411999 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593411999 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593411999 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593411999 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1010049143 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1010049143 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1010049143 SNP."
    },
    {
        "instruction": "In which chromosome is RS1010049143 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1010049143 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1010049143 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1010049143 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1010049143 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1010049143 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1010049143 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593529908 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593529908 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593529908 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593529908 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593529908 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593529908 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593529908 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593529908 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593529908 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593529908 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS763895695 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS763895695 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS763895695 SNP."
    },
    {
        "instruction": "In which chromosome is RS763895695 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS763895695 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS763895695 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS763895695 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS763895695 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS763895695 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS763895695 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS780654106 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS780654106 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS780654106 SNP."
    },
    {
        "instruction": "In which chromosome is RS780654106 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS780654106 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS780654106 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS780654106 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS780654106 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS780654106 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS780654106 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1014225642 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1014225642 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1014225642 SNP."
    },
    {
        "instruction": "In which chromosome is RS1014225642 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1014225642 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1014225642 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1014225642 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1014225642 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1014225642 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1014225642 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593414358 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593414358 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593414358 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593414358 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593414358 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593414358 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593414358 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593414358 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593414358 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593414358 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS771620677 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS771620677 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS771620677 SNP."
    },
    {
        "instruction": "In which chromosome is RS771620677 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS771620677 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS771620677 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS771620677 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS771620677 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS771620677 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS771620677 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593437266 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593437266 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593437266 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593437266 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593437266 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593437266 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593437266 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593437266 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593437266 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593437266 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1379479714 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1379479714 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1379479714 SNP."
    },
    {
        "instruction": "In which chromosome is RS1379479714 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1379479714 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1379479714 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1379479714 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1379479714 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1379479714 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1379479714 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS775381228 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS775381228 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS775381228 SNP."
    },
    {
        "instruction": "In which chromosome is RS775381228 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS775381228 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS775381228 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS775381228 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS775381228 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS775381228 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS775381228 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532040 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532040 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532040 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532040 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532040 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532040 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593532040 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532040 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532040 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532040 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS879124999 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS879124999 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS879124999 SNP."
    },
    {
        "instruction": "In which chromosome is RS879124999 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS879124999 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS879124999 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS879124999 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS879124999 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS879124999 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS879124999 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593443613 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593443613 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593443613 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593443613 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593443613 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593443613 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593443613 SNP?",
        "output": "The variation length is 4 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593443613 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593443613 SNP?",
        "output": "The variation is a Deletion."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593443613 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1304775415 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1304775415 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1304775415 SNP."
    },
    {
        "instruction": "In which chromosome is RS1304775415 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1304775415 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1304775415 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1304775415 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1304775415 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1304775415 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1304775415 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593534695 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593534695 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593534695 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593534695 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593534695 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593534695 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593534695 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593534695 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593534695 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593534695 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1014225642 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1014225642 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1014225642 SNP."
    },
    {
        "instruction": "In which chromosome is RS1014225642 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1014225642 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1014225642 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1014225642 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1014225642 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1014225642 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1014225642 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS762092062 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS762092062 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS762092062 SNP."
    },
    {
        "instruction": "In which chromosome is RS762092062 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS762092062 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS762092062 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS762092062 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS762092062 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS762092062 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS762092062 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532069 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532069 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532069 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532069 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532069 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532069 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593532069 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532069 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532069 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532069 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS371894780 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS371894780 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS371894780 SNP."
    },
    {
        "instruction": "In which chromosome is RS371894780 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS371894780 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS371894780 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS371894780 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS371894780 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS371894780 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS371894780 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS750057315 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS750057315 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS750057315 SNP."
    },
    {
        "instruction": "In which chromosome is RS750057315 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS750057315 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS750057315 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS750057315 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS750057315 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS750057315 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS750057315 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593411898 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593411898 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593411898 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593411898 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593411898 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593411898 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593411898 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593411898 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593411898 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593411898 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060504823 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060504823 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060504823 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060504823 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060504823 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060504823 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1060504823 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060504823 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060504823 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060504823 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060504824 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060504824 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060504824 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060504824 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060504824 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060504824 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1060504824 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060504824 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060504824 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060504824 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593539513 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593539513 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593539513 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593539513 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593539513 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593539513 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593539513 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593539513 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593539513 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593539513 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1555284937 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1555284937 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1555284937 SNP."
    },
    {
        "instruction": "In which chromosome is RS1555284937 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1555284937 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1555284937 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1555284937 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1555284937 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1555284937 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1555284937 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593547275 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593547275 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593547275 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593547275 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593547275 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593547275 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593547275 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593547275 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593547275 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593547275 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593446655 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593446655 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593446655 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593446655 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593446655 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593446655 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593446655 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593446655 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593446655 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593446655 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593532014 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593532014 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593532014 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593532014 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593532014 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593532014 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593532014 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593532014 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593532014 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593532014 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593434283 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593434283 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593434283 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593434283 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593434283 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593434283 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1593434283 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593434283 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593434283 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593434283 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1060504827 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1060504827 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1060504827 SNP."
    },
    {
        "instruction": "In which chromosome is RS1060504827 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1060504827 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1060504827 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1060504827 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1060504827 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1060504827 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1060504827 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS1021965284 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1021965284 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1021965284 SNP."
    },
    {
        "instruction": "In which chromosome is RS1021965284 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1021965284 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1021965284 SNP, is it benign or pathogenic?",
        "output": "It is Likely benign."
    },
    {
        "instruction": "How long is the variation length for RS1021965284 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1021965284 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS1021965284 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1021965284 SNP?",
        "output": "The resulting gene consequence is a synonymous variant."
    },
    {
        "instruction": "Which condition is asociated with RS3092886 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS3092886 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS3092886 SNP."
    },
    {
        "instruction": "In which chromosome is RS3092886 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS3092886 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS3092886 SNP, is it benign or pathogenic?",
        "output": "It is Benign."
    },
    {
        "instruction": "How long is the variation length for RS3092886 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS3092886 SNP?",
        "output": "The origin is germline."
    },
    {
        "instruction": "What is the type of genetic variation for RS3092886 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS3092886 SNP?",
        "output": "The resulting gene consequence is a intron variant."
    },
    {
        "instruction": "Which condition is asociated with RS1593455621 SNP?",
        "output": "Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors. The associated SNPedia page is https://www.snpedia.com/index.php/RsRS1593455621 SNP. The NCBI page is https://www.ncbi.nlm.nih.gov/snp/RS1593455621 SNP."
    },
    {
        "instruction": "In which chromosome is RS1593455621 SNP located?",
        "output": "It is located in the chromosome 13."
    },
    {
        "instruction": "Which methods support the evidence found for the RS1593455621 SNP?",
        "output": "Associated methods are: clinical testing."
    },
    {
        "instruction": "What is the clinical significance of RS1593455621 SNP, is it benign or pathogenic?",
        "output": "It is Pathogenic."
    },
    {
        "instruction": "How long is the variation length for RS1593455621 SNP?",
        "output": "The variation length is 1 base pairs."
    },
    {
        "instruction": "What is the origin for RS1593455621 SNP?",
        "output": "The origin is unknown."
    },
    {
        "instruction": "What is the type of genetic variation for RS1593455621 SNP?",
        "output": "The variation is a single nucleotide variant."
    },
    {
        "instruction": "What is the genetic molecular consequence for RS1593455621 SNP?",
        "output": "The resulting gene consequence is a nonsense."
    }
]