<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>What started out as a mere attempt to tentatively identify proteins in experimental
cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible
repository for theoretical pI/MW charts for 92 organisms. Using publicly available
expression data, we developed a collection of tissue-specific plots based on differential
gene expression between normal and diseased states. We use this comparative cancer
proteomics knowledge base, known as the tissue molecular anatomy project (TMAP),
to uncover threads of cancer markers common to several types of cancer and to relate
this information to established biological pathways.</p>
[]
Comp Funct Genomics. 2004 Mar; 5(2):196-200