<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Three mutant mice with pigmentation phenotypes were recovered from a genomewide
random mouse chemical mutagenesis study. White toes (<italic>Whto</italic>; MGI:1861986),
Belly spot and white toes (<italic>Bswt</italic>; MGI:2152776) and Dark footpads 2 (<italic>Dfp2</italic>;
MGI:1861991) were identified following visual inspection of progeny from a male
exposed to the point mutagen ethylnitrosourea (ENU). In order to rapidly localize
the causative mutations, genome-wide linkage scans were performed on pooled
DNA samples from backcross animals for each mutant line. <italic>Whto</italic> was mapped to
proximal mouse chromosome (Mmu) 7 between <italic>Cen</italic> (the centromere) and <italic>D7Mit112</italic>
(8.0 cM from the centromere), <italic>Bswt</italic> was mapped to centric Mmul between <italic>D1Mit214</italic>
(32.1 cM) and <italic>D1Mit480</italic> (32.8 cM) and <italic>Dfp2</italic> was mapped to proximalMmu4 between
<italic>Cen</italic> and <italic>D4Mit18</italic> (5.2 cM). <italic>Whto</italic>, <italic>Bswt</italic> and <italic>Dfp2</italic> may provide novel starting
points in furthering the elucidation of genetic and biochemical pathways relevant
to pigmentation and associated biological processes.</p>
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Comp Funct Genomics. 2004 Mar; 5(2):123-127