<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Liver blood flow measurements obtained from both the liver surface and deep within the parenchyma,
were correlated in an effort to assess the usefulness of laser-Doppler flowmetry for non-invasive
monitoring of total liver blood flow, the probe being positioned on either the surface or within the liver
parenchyma.</p> <p>In 23 Wistar rats and 10 biliary surgery patients, anaesthetized prior to gallbladder removal, liver
microcirculation was measured at 4 points on the capsular surface, and consequently at 4 points deep
within the parenchyma, using probes connected to a laser-Doppler flowmeter. The findings revealed
that laser-Doppler measurements on the liver surface and within the parenchyma were well correlated,
as no statistically significant differences were found either in rats or humans. It is concluded that laser-
Doppler flowmetry for monitoring of total liver perfusion can be applied either on the capsular surface
or within the hepatic parenchyma.</p>
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HPB Surg. 1992; 6(2):99-104