<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>A total of 6047 open reading frames in the <italic>Candida albicans</italic> genome were screened for
Zn(II)<sub>2</sub>C<sub>6</sub>-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA
recognition. These fungal proteins are transcription regulators of genes involved in a
wide range of cellular processes, including metabolism of different compounds such
as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell
wall architecture, etc. The selection criteria used in the sequence analysis were the
presence of the CysX<sub>2</sub>CysX<sub>6</sub>CysX<sub>5-16</sub>CysX<sub>2</sub>CysX<sub>6-8</sub>Cys motif and a putative nuclear localization signal. Using this approach, 70 putative 
Zn(II)<sub>2</sub>C<sub>6</sub> transcription factors have been found in the genome of <italic>C. albicans</italic>.</p>
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Comp Funct Genomics. 2005 Oct-Dec; 6(7-8):345-356