<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>DNA microarray technology is a high-throughput method for gaining information on gene function. Microarray technology is based on deposition/synthesis, in an ordered
manner, on a solid surface, of thousands of EST sequences/genes/oligonucleotides.
Due to the high number of generated datapoints, computational tools are essential in
microarray data analysis and mining to grasp knowledge from experimental results.
In this review, we will focus on some of the methodologies actually available to define
gene expression intensity measures, microarray data normalization, and statistical
validation of differential expression.</p>
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Comp Funct Genomics. 2003 Jul; 4(4):442-446