<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Though vanadium complexes mimic the action of insulin,
owing to their toxicity, research is still in progress for a new
vanadium complex with maximum efficacy at low concentration
and without any side effects. A novel macrocyclic
binuclear oxovanadium complex was synthesized, its composition
and structure were confirmed by spectral studies
and its efficacy was studied in streptozotocin-induced diabetic
rats over a period of 30 days. The oral administration
of the complex normalizes the blood glucose level in
the diabetic rats and also maintains normoglycemia after
a glucose load. The biochemical studies revealed that the
complex is not toxic to the system. The nontoxic nature of
this complex may be due to the presence of the vanadyl
ions in an intact form. The study highlights the nontoxic
and hypoglycemic effects of the new macrocyclic binuclear
oxovanadium complex.</p>
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Exp Diabesity Res. 2004; 5(2):137-142