<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Insulin secretion declines progressively before and during the
course of type 2 diabetes. Evidence indicates that this process is,
in part, secondary to increased requirement for insulin secretion
that is brought about by insulin resistance and by hyperglycemia.
The effects of over-secretion extend far beyond a mere reduction
of available insulin stores and may cause not only functional but
also structural damage. The time is ripe for clinical studies, which
explore the therapeutic potential of reducing over-secretion.</p>
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Int J Exp Diabetes Res. 2002; 3(3):153-158