<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>We treated two patients with a ruptured amebic liver abscess. The diagnosis was made at a relatively
early stage and treatment was successful for one patient, but an accurate diagnosis of liver abscess was
not made and invasive extraintestinal amebiasis led to multiple organ failure and to death for the other.
Neither patient had been outside of Japan, and both were heterosexual. The origins of <italic>Entamoeba histolytica</italic> infection could not be determined. Though the mortality rate is high in cases of ruptured
amebic liver abscess, appropriate management can lead to a good prognosis.</p>
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HPB Surg. 1990; 3(1):21-28