<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>The insulin-like growth factor (IGF) system in ubiquitous
and plays a role in every tissue of the body. It is comprised
of ligands, receptors and binding proteins, each with
specific functions. While it plays an essential role in embryonic
and post-natal development, the IGF system is also
important in normal adult physiology. There are now numerous
examples of diseases such as diabetes, cancer, and
malnutrition in which the IGF system is a major player and,
not surprisingly, there are attempts to affect these disorders
by manipulating the system.</p>
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Exp Diabesity Res. 2003; 4(4):205-212