<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>We have identified four novel repeats and two domains in cell surface proteins
encoded by the <italic>Methanosarcina acetivorans</italic> genome and in some archaeal and
bacterial genomes. The repeats correspond to a certain number of amino acid residues
present in tandem in a protein sequence and each repeat is characterized by conserved
sequence motifs. These correspond to: (a) a 42 amino acid (aa) residue RIVW repeat;
(b) a 45 aa residue LGxL repeat; (c) a 42 aa residue LVIVD repeat; and (d) a 54 aa
residue LGFP repeat. The domains correspond to a certain number of aa residues in
a protein sequence that do not comprise internal repeats. These correspond to: (a) a
200 aa residue DNRLRE domain; and (b) a 70 aa residue PEGA domain. We discuss
the occurrence of these repeats and domains in the different proteins and genomes
analysed in this work.</p>
[]
Comp Funct Genomics. 2004 Feb; 5(1):2-16