<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Microarray technology allows co-regulated genes to be identified. In order to identify genes that are controlled by specific regulators, gene expression can be compared
in mutant and wild-type bacteria. However, there are a number of pitfalls with this
approach; in particular, the regulator may not be active under the conditions in which
the wild-type strain is cultured. Once co-regulated genes have been identified, proteinbinding
motifs can be identified. By combining these data with a map of promoters,
or operons (the operome), the regulatory networks in the cell (the regulome) can start
to be built up.</p>
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Comp Funct Genomics. 2002 Aug; 3(4):352-354