<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Gene regulatory networks are a major focus of interest in molecular biology. A
crucial question is how complex regulatory systems are encoded and controlled by the
genome. Three recent publications have raised the question of what can be learned
about gene regulatory networks from microarray experiments on gene deletion
mutants. Using this indirect approach, topological features such as connectivity and
modularity have been studied.</p>
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Comp Funct Genomics. 2002 Dec; 3(6):499-503