<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for
interaction discovery, little attention has been paid to one of the best sources of
data: complexes of known three-dimensional (3D) structure. Here we discuss how
such complexes can be used to study and predict protein interactions and complexes,
and to interrogate interaction networks proposed by methods such as two-hybrid
screens or affinity purifications.</p>
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Comp Funct Genomics. 2003 Jul; 4(4):410-415