<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in <italic>β</italic>-cell function and in regulation of the <italic>β</italic>-cell mass. <italic>β</italic>-Cell transplantation, as well as approaches that replenish or preserve the endogenous <italic>β</italic>-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.</p>
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Int J Exp Diabesity Res. 2003; 4(1):1-5