<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p><italic>Bacillus subtilis</italic> is a sporulating Gram-positive bacterium that lives primarily in the soil
and associated water sources. The publication of the <italic>B. subtilis</italic> genome sequence and
subsequent systematic functional analysis and gene regulation programmes, together with
an extensive understanding of its biochemistry and physiology, makes this micro-organism
a prime candidate in which to model regulatory networks <italic>in silico.</italic> In this paper we discuss
combined molecular biological and bioinformatical approaches that are being developed to
model this organism’s responses to changes in its environment.</p>
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Comp Funct Genomics. 2002 Feb; 3(1):37-41