<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Highly specific high-throughput assays will be required to take full advantage of the accumulating information about the macromolecular composition of cells and
tissues, in order to characterize biological systems in health and disease. We discuss
the general problem of detection specificity and present the approach our group
has taken, involving the reformatting of analogue biological information to digital
reporter segments of genetic information via a series of DNA ligation assays. The
assays enable extensive, coordinated analyses of the numbers and locations of genes,
transcripts and protein.</p>
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Comp Funct Genomics. 2003 Oct; 4(5):525-530