<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>All of the mouse models of human trisomy 21 syndrome that have been studied so far are based on segmental trisomies, encompassing, to a varying extent, distal
chromosome 16. Their comparison with one or more unrelated and non-overlapping
segmental trisomies may help to distinguish the effects of specific triplicated genes
from the phenotypes caused by less specific developmental instability mechanisms. In
this paper, the Ts43H segmental trisomy of mouse chromosome 17 is presented as such
an alternative model. The trisomy stretches over 32.5 Mb of proximal chromosome
17 and includes 486 genes. The triplicated interval carries seven blocks of synteny
with five human chromosomes. The block syntenic to human chromosome 21 contains
20 genes.</p>
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Comp Funct Genomics. 2003 Dec; 4(6):647-652