<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>The effect of <italic>Gymnema montanum</italic> leaves on alloxaninduced
hyperlipidemia was studied in male Wistar rats.
Ethanolic extract of <italic>G. montanum</italic> leaves was administered
orally and different doses of the extract on blood glucose,
serum and tissue lipids, hexokinase, glucose-6-phosphatase,
thiobarbituric acid–reactive substances (TBARS), hydroperoxides,
and glutathione in alloxan-induced diabetic
rats were studied. <italic>G. montanum</italic> leaf extract (GLEt) at doses
of 50, 100, 200 mg/kg body weight for 3 weeks suppressed
the elevated blood glucose and lipid levels in diabetic rats.
GLEt at 200 mg/kg body weight was found to be comparable
to glibenclamide, a reference drug. These data indicate
that <italic>G. montanum</italic> represents an effective antihyperglycemic
and antihyperlipidemic adjunct for the treatment
of diabetes and a potential source of discovery of new orally
active agent for future therapy.</p>
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Exp Diabesity Res. 2003; 4(3):183-189