<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Yeast deletion strains created during gene function analysis projects very often show
drastic phenotypic differences depending on the genetic background used. These results
indicate the existence of important molecular differences between the CEN.PK2, FY1679
and W303 wild type strains. To characterise these differences we have compared the
protein expression levels between CEN.PK2, FY1679 and W303 strains using twodimensional
gel electrophoresis and identified selected proteins by mass spectrometric
analysis. We have found that FY1679 and W303 strains are more similar to each other
than to the CEN.PK2 strain. This study identifies 62 proteins that are differentially
expressed between the strains and provides a valuable source of data for the interpretation
of yeast mutant phenotypes observed in CEN.PK2, FY1679 and W303 strains.</p>
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Comp Funct Genomics. 2001 Aug; 2(4):207-225