<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Acute necrotising pancreatitis is associated with an unacceptably high mortality for which no
satisfactory remedy exists. Emblica officinalis (E.o.) is a plant prescribed in Ayurveda, the
Indian traditional system of medicine, for pancreas-related disorders. This study was carried
out to evaluate the protective effect of E.o. against acute necrotising pancreatitis in dogs.
Pancreatitis was induced by injecting a mixture of trypsin, bile and blood into the duodenal
opening of the pancreatic duct. Twenty eight dogs were divided into 4 groups (n = 6-8 each):
GpI–control, GpII–acute pancreatitis, GpIII–sham-operated, GpIV–pretreatment with
28 mg E.o./kg/day for 15 days before inducing pancreatitis. Serum amylase increased from
541.99 ± 129.13 IU/ml to 1592.63 ± 327.83 IU (p&lt;0.02) 2 hrs after the induction of pancreatitis
in GpII. The rise in serum amylase in both GpIII and GpIV was not significant. On
light microscopic examination, acinar cell damage was less and the total inflammatory score
was significantly lower in the E.o. treated group as compared to GpII. Electron microscopy
confirmed this and showed an increased amount of smooth, endoplasmic reticulum and small,
condensed granules embedded in a vacuole. More studies are needed to explore the clinical
potential of E.o. and its mechanism of action.</p>
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HPB Surg. 1995; 9(1):25-30