<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Twenty patients underwent a pylorus-preserving pancreatoduodenectomy for benign or malignant
periampullary and pancreatic disease. Eighteen patients had a partial and two patients a total
pancreatectomy. There were 19 elective and 1 emergency operations.</p> <p>Post-operative mortality was 4% (1/20 patients) and the median follow up was 31 months (range, 15–
75 months), during which period 8 patients with a malignant disease died.</p> <p>Pylorus-preserving pancreatoduodenectomy did not compromise survival in ampullary cancer.</p> <p>One patient developed a marginal ulcer during the study period and one of twelve patients, examined
by technetium scintigraphy (done more than 3 months after the procedure), had delayed gastric
emptying. Two patients presented with a gastric retention as the first sign of recurrent pancreatic cancer.</p> <p>The result of the operation was judged as excellent in 7 patients, good in 8 and as bad in only 2 of the
17 patients who survived more than <italic>6 months</italic> . Body weight was studied in 15 patients surviving more
than <italic>one year</italic> after operation; five patients had gained weight, two had lost weight and in 8 there was no
difference.</p> <p>Pylorus-preserving pancreatoduodenectomy seems to be a valuable alternative in the treatment of
patients with benign and selected malignant pancreaticobiliary disease.</p>
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HPB Surg. 1991; 4(2):109-119