<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>In recent years the physiological role of the proinsulin
C-peptide has received increasing attention,
focusing on the potential therapeutic value of
C-peptide replacement in preventing and ameliorating
type 1 diabetic complications. In order to consolidate
these new data and to identify the immediate
directions of C-peptide research and its clinical
usefulness, an International Symposium was held
in Detroit, Michigan, on October 20–21, 2000, under
the auspices of the Wayne State University/Morris
Hood Jr. Comprehensive Diabetes Center. In this
communication, we review the cellular, physiological
and clinical effects of C-peptide replacement in
animal models and in patients with type 1 diabetes.
Finally, recommendations are presented as to the
most urgent studies that should be pursued to further
establish the biological action of C-peptide and
its therapeutic value.</p>
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Int J Exp Diabetes Res. 2001; 2(2):145-151