<p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> <p>Maternal diabetes induces fetal alterations, resulting
in lasting consequences for the glucose tolerance
of the offspring over several generations. In our
experimental rat model, circulating prolactin, oestradiol,
progesterone and corticosterone levels,
known to influence insulin secretion and action,
are determined in plasma of female adult offspring
of mildly and severely diabetic mothers. Prolactin
and progesterone levels are equally low in both
groups as compared to controls, stressing the involvement
of the CNS in the transgeneration effect;
oestradiol and corticosterone levels are normal. No
correlation is found between these hormonal alterations
and the known differences in glucose
tolerance.</p>
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Int J Exp Diabetes Res. 2000; 1(1):31-38