how long after the third prion characterization would it take for another to be characterized?
6 years
col : protein | natural host | normal function | prion state | prion phenotype | year identified row 1 : ure2p | saccharomyces cerevisiae | nitrogen catabolite repressor | [ure3] | growth on poor nitrogen sources | 1994 row 2 : sup35p | saccharomyces cerevisiae | translation termination factor | [psi+] | increased levels of nonsense suppression | 1994 row 3 : het-s | podospora anserina | regulates heterokaryon incompatibility | [het-s] | heterokaryon formation between incompatible strains | 1997 row 4 : vacuolar protease b | saccharomyces cerevisiae | death in stationary phase, failure in meiosis | [β] | failure to degrade cellular proteins under n starvation | 2003 row 5 : map kinases | podospora anserina | increased pigment, slow growth | [c] |  | 2006 row 6 : rnq1p | saccharomyces cerevisiae | protein template factor | [rnq+],[pin+] | promotes aggregation of other prions | 2008 row 7 : mca1* | saccharomyces cerevisiae | putative yeast caspase | [mca+] | unknown | 2008 row 8 : swi1 | saccharomyces cerevisiae | chromatin remodeling | [swi+] | poor growth on some carbon sources | 2008 row 9 : cyc8 | saccharomyces cerevisiae | transcriptional repressor | [oct+] | transcriptional derepression of multiple genes | 2009 row 10 : mot3 | saccharomyces cerevisiae | nuclear transcription factor | [mot3+] | transcriptional derepression of anaerobic genes | 2009 row 11 : pma1+std1 | saccharomyces cerevisiae | pma1 = major plasma membrane proton pump, std1 | [gar+] | resistant to glucose-associated repression | 2009 row 12 : sfp1 | saccharomyces cerevisiae | global transcriptional regulator | [isp+] | antisuppressor of certain sup35 mutations | 2010 row 13 : mod5 | saccharomyces cerevisiae |  | [mod+] |  | 2012
how long after the third prion characterization would it take for another to be characterized?
Protein Natural Host Normal Function Prion State Prion Phenotype Year Identified
Ure2p Saccharomyces cerevisiae Nitrogen catabolite repressor [URE3] Growth on poor nitrogen sources 1994
Sup35p Saccharomyces cerevisiae Translation termination factor [PSI+] Increased levels of nonsense suppression 1994
HET-S Podospora anserina Regulates heterokaryon incompatibility [Het-s] Heterokaryon formation between incompatible strains 1997
vacuolar protease B Saccharomyces cerevisiae death in stationary phase, failure in meiosis [β] failure to degrade cellular proteins under N starvation 2003
MAP kinases Podospora anserina increased pigment, slow growth [C] 2006
Rnq1p Saccharomyces cerevisiae Protein template factor [RNQ+],[PIN+] Promotes aggregation of other prions 2008
Mca1* Saccharomyces cerevisiae Putative Yeast Caspase [MCA+] Unknown 2008
Swi1 Saccharomyces cerevisiae Chromatin remodeling [SWI+] Poor growth on some carbon sources 2008
Cyc8 Saccharomyces cerevisiae Transcriptional repressor [OCT+] Transcriptional derepression of multiple genes 2009
Mot3 Saccharomyces cerevisiae Nuclear transcription factor [MOT3+] Transcriptional derepression of anaerobic genes 2009
Pma1+Std1 Saccharomyces cerevisiae Pma1 = major plasma membrane proton pump, Std1=minor pump [GAR+] Resistant to glucose-associated repression 2009
Sfp1 Saccharomyces cerevisiae Global transcriptional regulator [ISP+] Antisuppressor of certain sup35 mutations 2010
Mod5 Saccharomyces cerevisiae [MOD+] 2012
6 years