what cancers are growth factors associated with?
glioblastomas, fibrosarcomas, osteosarcomas, breast carcinomas, and melanomas
col : category | examples | cancers | gene functions row 1 : growth factors, or mitogens | c-sis | glioblastomas, fibrosarcomas, | induces cell proliferation. row 2 : receptor tyrosine kinases | epidermal growth factor receptor (egfr), platelet-derived growth | breast cancer, gastrointestinal stromal tumours, non-small- | transduce signals for cell growth and differentiation. row 3 : cytoplasmic tyrosine kinases | src-family, syk-zap-70 family, | colorectal and breast cancers, melanomas, | mediate the responses to, and the activation receptors of cell row 4 : cytoplasmic serine/threonine kinases | raf kinase, and cyclin-dependent | malignant melanoma, papillary thyroid cancer, color | involved in organism development, cell cycle regulation, cell proliferation, row 5 : regulatory gtpases | ras protein | adenocarcinomas of the pancreas and colon | involved in signalling a major pathway leading to cell proliferation. row 6 : transcription factors | myc gene | malignant t-cell lymphomas and acute myleoid | -they regulate transcription of genes that induce cell proliferation.
what cancers are growth factors associated with?
Category Examples Cancers Gene functions
Growth factors, or mitogens c-Sis glioblastomas, fibrosarcomas, osteosarcomas, breast carcinomas, and melanomas induces cell proliferation.
Receptor tyrosine kinases epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR), HER2/neu Breast cancer, gastrointestinal stromal tumours, non-small-cell lung cancer and pancreatic cancer transduce signals for cell growth and differentiation.
Cytoplasmic tyrosine kinases Src-family, Syk-ZAP-70 family, and BTK family of tyrosine kinases, the Abl gene in CML - Philadelphia chromosome colorectal and breast cancers, melanomas, ovarian cancers, gastric cancers, head and neck cancers, pancreatice cancer, lung cancer, brain cancers, and blood cancers mediate the responses to, and the activation receptors of cell proliferation, migration, differentiation, and survival
Cytoplasmic Serine/threonine kinases and their regulatory subunits Raf kinase, and cyclin-dependent kinases (through overexpression). malignant melanoma, papillary thyroid cancer, colorectal cancer, and ovarian cancer Involved in organism development, cell cycle regulation, cell proliferation, differentiation, cells survival, and apoptosis
Regulatory GTPases Ras protein adenocarcinomas of the pancreas and colon, thyroid tumors, and myeloid leukemia involved in signalling a major pathway leading to cell proliferation.
Transcription factors myc gene malignant T-cell lymphomas and acute myleoid leukemias, breast cancer, pancreatic cancer, retinoblastoma, and small cell lung cancer -They regulate transcription of genes that induce cell proliferation.
glioblastomas, fibrosarcomas, osteosarcomas, breast carcinomas, and melanomas