Understanding the PULSAR Effect in Combined Radiotherapy and Immunotherapy through Attention Mechanisms with a Transformer Model
<|reference_start|>Understanding the PULSAR Effect in Combined Radiotherapy and Immunotherapy through Attention Mechanisms with a Transformer Model: PULSAR (personalized, ultra-fractionated stereotactic adaptive radiotherapy) is the adaptation of stereotactic ablative radiotherapy towards personalized cancer management. For the first time, we applied a transformer-based attention mechanism to investigate the underlying interactions between combined PULSAR and PD-L1 blockade immunotherapy based on a murine cancer model (Lewis Lung Carcinoma, LLC). The proposed approach is able to predict the trend of tumor volume change semi-quantitatively, and excels in identifying the potential causal relationships through both self-attention and cross-attention scores.<|reference_end|>
@article{peng2024understanding,
    title={Understanding the PULSAR Effect in Combined Radiotherapy and
  Immunotherapy through Attention Mechanisms with a Transformer Model},
    author={Hao Peng, Casey Moore, Debabrata Saha, Steve Jiang and Robert
  Timmerman},
    journal={arXiv preprint arXiv:2403.04175},
    year={2024},
    archivePrefix={arXiv},
    eprint={2403.04175},
    primaryClass={physics.med-ph cs.AI}
}