Integrating multiscale topology in digital pathology with pyramidal graph convolutional networks
<|reference_start|>Integrating multiscale topology in digital pathology with pyramidal graph convolutional networks: Graph convolutional networks (GCNs) have emerged as a powerful alternative to multiple instance learning with convolutional neural networks in digital pathology, offering superior handling of structural information across various spatial ranges - a crucial aspect of learning from gigapixel H&E-stained whole slide images (WSI). However, graph message-passing algorithms often suffer from oversmoothing when aggregating a large neighborhood. Hence, effective modeling of multi-range interactions relies on the careful construction of the graph. Our proposed multi-scale GCN (MS-GCN) tackles this issue by leveraging information across multiple magnification levels in WSIs. MS-GCN enables the simultaneous modeling of long-range structural dependencies at lower magnifications and high-resolution cellular details at higher magnifications, akin to analysis pipelines usually conducted by pathologists. The architecture's unique configuration allows for the concurrent modeling of structural patterns at lower magnifications and detailed cellular features at higher ones, while also quantifying the contribution of each magnification level to the prediction. Through testing on different datasets, MS-GCN demonstrates superior performance over existing single-magnification GCN methods. The enhancement in performance and interpretability afforded by our method holds promise for advancing computational pathology models, especially in tasks requiring extensive spatial context.<|reference_end|>
@article{ibañez2024integrating,
    title={Integrating multiscale topology in digital pathology with pyramidal
  graph convolutional networks},
    author={Victor Iba~nez, Przemyslaw Szostak, Quincy Wong, Konstanty Korski,
  Samaneh Abbasi-Sureshjani, Alvaro Gomariz},
    journal={arXiv preprint arXiv:2403.15068},
    year={2024},
    archivePrefix={arXiv},
    eprint={2403.15068},
    primaryClass={eess.IV cs.CV}
}