Deconvolving Complex Neuronal Networks into Interpretable Task-Specific Connectomes
<|reference_start|>Deconvolving Complex Neuronal Networks into Interpretable Task-Specific Connectomes: Task-specific functional MRI (fMRI) images provide excellent modalities for studying the neuronal basis of cognitive processes. We use fMRI data to formulate and solve the problem of deconvolving task-specific aggregate neuronal networks into a set of basic building blocks called canonical networks, to use these networks for functional characterization, and to characterize the physiological basis of these responses by mapping them to regions of the brain. Our results show excellent task-specificity of canonical networks, i.e., the expression of a small number of canonical networks can be used to accurately predict tasks; generalizability across cohorts, i.e., canonical networks are conserved across diverse populations, studies, and acquisition protocols; and that canonical networks have strong anatomical and physiological basis. From a methods perspective, the problem of identifying these canonical networks poses challenges rooted in the high dimensionality, small sample size, acquisition variability, and noise. Our deconvolution technique is based on non-negative matrix factorization (NMF) that identifies canonical networks as factors of a suitably constructed matrix. We demonstrate that our method scales to large datasets, yields stable and accurate factors, and is robust to noise.<|reference_end|>
@article{wang2024deconvolving,
    title={Deconvolving Complex Neuronal Networks into Interpretable Task-Specific
  Connectomes},
    author={Yifan Wang and Vikram Ravindra and Ananth Grama},
    journal={arXiv preprint arXiv:2407.00201},
    year={2024},
    archivePrefix={arXiv},
    eprint={2407.00201},
    primaryClass={q-bio.NC cs.LG eess.IV}
}