Fully Automated OCT-based Tissue Screening System
<|reference_start|>Fully Automated OCT-based Tissue Screening System: This study introduces a groundbreaking optical coherence tomography (OCT) imaging system dedicated for high-throughput screening applications using ex vivo tissue culture. Leveraging OCT's non-invasive, high-resolution capabilities, the system is equipped with a custom-designed motorized platform and tissue detection ability for automated, successive imaging across samples. Transformer-based deep learning segmentation algorithms further ensure robust, consistent, and efficient readouts meeting the standards for screening assays. Validated using retinal explant cultures from a mouse model of retinal degeneration, the system provides robust, rapid, reliable, unbiased, and comprehensive readouts of tissue response to treatments. This fully automated OCT-based system marks a significant advancement in tissue screening, promising to transform drug discovery, as well as other relevant research fields.<|reference_end|>
@article{pi2024fully,
    title={Fully Automated OCT-based Tissue Screening System},
    author={Shaohua Pi, Razieh Ganjee, Lingyun Wang, Riley K. Arbuckle, Chengcheng
  Zhao, Jose A Sahel, Bingjie Wang, Yuanyuan Chen},
    journal={arXiv preprint arXiv:2405.09601},
    year={2024},
    doi={10.1364/OL.530281},
    archivePrefix={arXiv},
    eprint={2405.09601},
    primaryClass={physics.med-ph cs.CV}
}