Data Alchemy: Mitigating Cross-Site Model Variability Through Test Time Data Calibration
<|reference_start|>Data Alchemy: Mitigating Cross-Site Model Variability Through Test Time Data Calibration: Deploying deep learning-based imaging tools across various clinical sites poses significant challenges due to inherent domain shifts and regulatory hurdles associated with site-specific fine-tuning. For histopathology, stain normalization techniques can mitigate discrepancies, but they often fall short of eliminating inter-site variations. Therefore, we present Data Alchemy, an explainable stain normalization method combined with test time data calibration via a template learning framework to overcome barriers in cross-site analysis. Data Alchemy handles shifts inherent to multi-site data and minimizes them without needing to change the weights of the normalization or classifier networks. Our approach extends to unseen sites in various clinical settings where data domain discrepancies are unknown. Extensive experiments highlight the efficacy of our framework in tumor classification in hematoxylin and eosin-stained patches. Our explainable normalization method boosts classification tasks' area under the precision-recall curve(AUPR) by 0.165, 0.545 to 0.710. Additionally, Data Alchemy further reduces the multisite classification domain gap, by improving the 0.710 AUPR an additional 0.142, elevating classification performance further to 0.852, from 0.545. Our Data Alchemy framework can popularize precision medicine with minimal operational overhead by allowing for the seamless integration of pre-trained deep learning-based clinical tools across multiple sites.<|reference_end|>
@article{parida2024data,
    title={Data Alchemy: Mitigating Cross-Site Model Variability Through Test Time
  Data Calibration},
    author={Abhijeet Parida, Antonia Alomar, Zhifan Jiang, Pooneh Roshanitabrizi,
  Austin Tapp, Maria Ledesma-Carbayo, Ziyue Xu, Syed Muhammed Anwar, Marius
  George Linguraru, Holger R. Roth},
    journal={arXiv preprint arXiv:2407.13632},
    year={2024},
    archivePrefix={arXiv},
    eprint={2407.13632},
    primaryClass={cs.CV cs.LG eess.IV}
}