BrainMorph: A Foundational Keypoint Model for Robust and Flexible Brain MRI Registration
<|reference_start|>BrainMorph: A Foundational Keypoint Model for Robust and Flexible Brain MRI Registration: We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable groupwise registration. BrainMorph is trained on a massive dataset of over 100,000 3D volumes, skull-stripped and non-skull-stripped, from nearly 16,000 unique healthy and diseased subjects. BrainMorph is robust to large misalignments, interpretable via interrogating automatically-extracted keypoints, and enables rapid and controllable generation of many plausible transformations with different alignment types and different degrees of nonlinearity at test-time. We demonstrate the superiority of BrainMorph in solving 3D rigid, affine, and nonlinear registration on a variety of multi-modal brain MRI scans of healthy and diseased subjects, in both the pairwise and groupwise setting. In particular, we show registration accuracy and speeds that surpass current state-of-the-art methods, especially in the context of large initial misalignments and large group settings. All code and models are available at https://github.com/alanqrwang/brainmorph.<|reference_end|>
@article{wang2024brainmorph:,
    title={BrainMorph: A Foundational Keypoint Model for Robust and Flexible Brain
  MRI Registration},
    author={Alan Q. Wang, Rachit Saluja, Heejong Kim, Xinzi He, Adrian Dalca, and
  Mert R. Sabuncu},
    journal={arXiv preprint arXiv:2405.14019},
    year={2024},
    archivePrefix={arXiv},
    eprint={2405.14019},
    primaryClass={cs.CV}
}