A novel application of Shapley values for large multidimensional time-series data: Applying explainable AI to a DNA profile classification neural network
<|reference_start|>A novel application of Shapley values for large multidimensional time-series data: Applying explainable AI to a DNA profile classification neural network: The application of Shapley values to high-dimensional, time-series-like data is computationally challenging - and sometimes impossible. For $N$ inputs the problem is $2^N$ hard. In image processing, clusters of pixels, referred to as superpixels, are used to streamline computations. This research presents an efficient solution for time-seres-like data that adapts the idea of superpixels for Shapley value computation. Motivated by a forensic DNA classification example, the method is applied to multivariate time-series-like data whose features have been classified by a convolutional neural network (CNN). In DNA processing, it is important to identify alleles from the background noise created by DNA extraction and processing. A single DNA profile has $31,200$ scan points to classify, and the classification decisions must be defensible in a court of law. This means that classification is routinely performed by human readers - a monumental and time consuming process. The application of a CNN with fast computation of meaningful Shapley values provides a potential alternative to the classification. This research demonstrates the realistic, accurate and fast computation of Shapley values for this massive task<|reference_end|>
@article{elborough2024a,
    title={A novel application of Shapley values for large multidimensional
  time-series data: Applying explainable AI to a DNA profile classification
  neural network},
    author={Lauren Elborough, Duncan Taylor, Melissa Humphries},
    journal={arXiv preprint arXiv:2409.18156},
    year={2024},
    archivePrefix={arXiv},
    eprint={2409.18156},
    primaryClass={q-bio.QM cs.LG q-bio.GN stat.ML}
}