Automatically Labeling $200B Life-Saving Datasets: A Large Clinical Trial Outcome Benchmark
<|reference_start|>Automatically Labeling $200B Life-Saving Datasets: A Large Clinical Trial Outcome Benchmark: The global cost of drug discovery and development exceeds $200 billion annually. The main results of drug discovery and development are the outcomes of clinical trials, which directly influence the regulatory approval of new drug candidates and ultimately affect patient outcomes. Despite their significance, large-scale, high-quality clinical trial outcome data are not readily available to the public. Suppose a large clinical trial outcome dataset is provided; machine learning researchers can potentially develop accurate prediction models using past trials and outcome labels, which could help prioritize and optimize therapeutic programs, ultimately benefiting patients. This paper introduces Clinical Trial Outcome (CTO) dataset, the largest trial outcome dataset with around 479K clinical trials, aggregating outcomes from multiple sources of weakly supervised labels, minimizing the noise from individual sources, and eliminating the need for human annotation. These sources include large language model (LLM) decisions on trial-related documents, news headline sentiments, stock prices of trial sponsors, trial linkages across phases, and other signals such as patient dropout rates and adverse events. CTO's labels show unprecedented agreement with supervised clinical trial outcome labels from test split of the supervised TOP dataset, with a 91 F1.<|reference_end|>
@article{gao2024automatically,
    title={Automatically Labeling $200B Life-Saving Datasets: A Large Clinical
  Trial Outcome Benchmark},
    author={Chufan Gao, Jathurshan Pradeepkumar, Trisha Das, Shivashankar Thati,
  Jimeng Sun},
    journal={arXiv preprint arXiv:2406.10292},
    year={2024},
    archivePrefix={arXiv},
    eprint={2406.10292},
    primaryClass={cs.AI cs.CL cs.LG}
}