A: The variant NC_000020.11:g.33781315C>G in gene ZNF341 is classified as 'Pathogenic' for Hyper-IgE_recurrent_infection_syndrome_3,_autosomal_recessive. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032654,MedGen:C4748969,OMIM:618282. Review status: criteria provided, single submitter.