A: The variant NC_000022.11:g.28734445del in gene CHEK2 is classified as 'Pathogenic' for Predisposition_to_cancer|Familial_cancer_of_breast|Breast-ovarian_cancer,_familial,_susceptibility_to,_1|CHEK2-related_cancer_predisposition|not_provided|Hereditary_cancer-predisposing_syndrome|Hereditary_breast_ovarian_cancer_syndrome. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Deletion. Disease database links: .|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0011450,MedGen:C2676676,OMIM:604370,Orphanet:145|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145. Review status: criteria provided, multiple submitters, no conflicts.