A: The variant NC_000021.9:g.34859534G>A in gene RUNX1 is classified as 'Pathogenic' for Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011071,MedGen:CN281654,Orphanet:71290. Review status: reviewed by expert panel. Oncogenicity: ONC: Likely_oncogenic, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005094027