A: The variant NC_000022.11:g.18121458_18121471del in gene TUBA8 is classified as 'Uncertain_significance' for Polymicrogyria_with_optic_nerve_hypoplasia. Molecular consequence: SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0013172,MedGen:C2750798,Orphanet:250972. Review status: no assertion criteria provided.