A: The variant NC_000020.11:g.46122366C>T in gene CD40 is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Hyper-IgM_syndrome_type_3. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090. Review status: criteria provided, conflicting classifications.