A: The variant NC_000022.11:g.50525778G>A in gene TYMP is classified as 'Uncertain_significance' for not_provided|not_specified|Mitochondrial_DNA_depletion_syndrome_1|TYMP-related_disorder. Molecular consequence: SO:0001587: nonsense,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0011283,MedGen:C4551995,OMIM:603041,Orphanet:298|.. Review status: criteria provided, multiple submitters, no conflicts.