A: The variant NC_000022.11:g.20991791del in gene LZTR1 is classified as 'Conflicting_classifications_of_pathogenicity' for Noonan_syndrome_2|Congenital_diaphragmatic_hernia|Cardiovascular_phenotype|Hereditary_cancer-predisposing_syndrome|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|Human_Phenotype_Ontology:HP:0000776,Human_Phenotype_Ontology:HP:0006604,MONDO:MONDO:0005711,MeSH:D065630,MedGen:C0235833,OMIM:PS142340,Orphanet:2140|MedGen:CN230736|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900. Review status: criteria provided, conflicting classifications.