A: The variant NC_000019.10:g.38496957G>T in gene RYR1 is classified as 'Uncertain_significance' for Central_core_myopathy|Central_core_disease,_autosomal_recessive|Centronuclear_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|Multiminicore_myopathy|Congenital_myopathy_with_fiber_type_disproportion|RYR1-related_disorder. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MedGen:C4016368|MONDO:MONDO:0018947,MedGen:C0175709,OMIM:PS160150,Orphanet:595|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0018948,MedGen:C0270962,Orphanet:598|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MedGen:CN239331. Review status: criteria provided, multiple submitters, no conflicts.