A: The variant NC_000022.11:g.28695868_28695869del in gene CHEK2 is classified as 'Pathogenic' for Nephroblastoma. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0000115,Human_Phenotype_Ontology:HP:0002667,MONDO:MONDO:0006058,MeSH:D009396,MedGen:C0027708,Orphanet:654. Review status: no assertion criteria provided.