A: The variant NC_000022.11:g.41527385G>A in gene ACO2 is classified as 'Uncertain_significance' for Infantile_cerebellar-retinal_degeneration|Optic_atrophy_9|not_provided|Inborn_genetic_diseases. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013802,MedGen:C3281192,OMIM:614559,Orphanet:313850|MONDO:MONDO:0014571,MedGen:C4225384,OMIM:616289|MedGen:C3661900|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.