A: The variant NC_000019.10:g.45495106T>C in gene RTN2 is classified as 'Uncertain_significance' for Hereditary_spastic_paraplegia. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019064,MedGen:C0037773,OMIM:PS303350,Orphanet:685. Review status: criteria provided, single submitter.