A: The variant NC_000022.11:g.28689182_28689186del in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Familial_cancer_of_breast|Incidental_Discovery|Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:C1135954|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, multiple submitters, no conflicts.