A: The variant NC_000021.9:g.25891820G>C in gene APP is classified as 'Likely_pathogenic' for CEREBRAL_AMYLOID_ANGIOPATHY,_APP-RELATED,_PIEDMONT_VARIANT|Cerebral_amyloid_angiopathy,_APP-related|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458|MedGen:C3661900. Review status: criteria provided, single submitter.