A: The variant NC_000020.11:g.58854155del in gene GNAS is classified as 'Uncertain_significance' for Progressive_osseous_heteroplasia|Pseudohypoparathyroidism_type_I_A|Pseudopseudohypoparathyroidism|GNAS-related_disorder|not_specified. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0025027,MONDO:MONDO:0008153,MedGen:C0334041,OMIM:166350,Orphanet:2762|MONDO:MONDO:0007078,MedGen:C3494506,OMIM:103580,Orphanet:79443|MONDO:MONDO:0012912,MedGen:C0033835,OMIM:612463,Orphanet:79445|.|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.