A: The variant NC_000019.10:g.41904371G>A in gene ARHGEF1 is classified as 'Uncertain_significance' for not_provided|not_specified|Immunodeficiency_62. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0032763,MedGen:C5193109,OMIM:618459. Review status: criteria provided, multiple submitters, no conflicts.