A: The variant NC_000021.9:g.42385407A>G in gene TMPRSS3 is classified as 'Pathogenic' for Autosomal_recessive_nonsyndromic_hearing_loss_8. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636. Review status: criteria provided, single submitter.