A: The variant NC_000019.10:g.42249220_42249221del in gene ERF is classified as 'Pathogenic/Likely_pathogenic' for Craniosynostosis_4|Chitayat_syndrome|See_cases|not_provided|TWIST1-related_craniosynostosis|Inborn_genetic_diseases. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0004443,Human_Phenotype_Ontology:HP:0004486,MONDO:MONDO:0010929,MedGen:C1833340,OMIM:600775|MONDO:MONDO:0014956,MedGen:C4310679,OMIM:617180|.|MedGen:C3661900|MONDO:MONDO:0007399,MedGen:C4551902,OMIM:123100,Orphanet:63440|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.