A: The variant NC_000022.11:g.28725352T>C in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for not_specified|Hereditary_cancer-predisposing_syndrome|not_provided|Breast_neoplasm|Familial_cancer_of_breast|Colorectal_cancer. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|Human_Phenotype_Ontology:HP:0010623,Human_Phenotype_Ontology:HP:0100013,MONDO:MONDO:0021100,MeSH:D001943,MedGen:C1458155|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500. Review status: criteria provided, conflicting classifications.