A: The variant NC_000019.10:g.15181645A>T in gene NOTCH3 is classified as 'Uncertain_significance' for Inborn_genetic_diseases|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136. Review status: criteria provided, multiple submitters, no conflicts.