A: The variant NC_000019.10:g.45766415T>C in gene SIX5 is classified as 'Uncertain_significance' for Branchiootorenal_syndrome_2. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0012575,MedGen:C1970479,OMIM:610896,Orphanet:107. Review status: criteria provided, single submitter.