A: The variant NC_000020.11:g.59324602C>G in gene EDN3 is classified as 'Uncertain_significance' for Hirschsprung_disease,_susceptibility_to,_4. Molecular consequence: SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013384,MedGen:C3150975,OMIM:613712,Orphanet:388. Review status: criteria provided, single submitter.