A: The variant NC_000019.10:g.15189329C>G in gene NOTCH3 is classified as 'Likely_pathogenic' for not_provided|Stroke_disorder|Migraine_with_aura|Depression. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0001297,Human_Phenotype_Ontology:HP:0002452,MONDO:MONDO:0005098,MeSH:D020521,MedGen:C0038454|Human_Phenotype_Ontology:HP:0002077,MONDO:MONDO:0005475,MedGen:C0154723|Human_Phenotype_Ontology:HP:0000716,MONDO:MONDO:0002050,MeSH:D003866,MedGen:C0011581. Review status: criteria provided, single submitter.