A: The variant NC_000021.9:g.44286698C>T in gene AIRE is classified as 'Pathogenic/Likely_pathogenic' for Polyglandular_autoimmune_syndrome,_type_1|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009411,MedGen:C0085859,OMIM:240300,Orphanet:3453|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.