A: The variant NC_000019.10:g.49835019TG[1] in gene MED25 is classified as 'Uncertain_significance' for Charcot-Marie-Tooth_disease_type_2|Tip-toe_gait. Molecular consequence: SO:0001587: nonsense,SO:0001589: frameshift_variant. Variant type: Microsatellite. Disease database links: MONDO:MONDO:0018993,MedGen:C0270914,Orphanet:64746|Human_Phenotype_Ontology:HP:0002394,Human_Phenotype_Ontology:HP:0030051,Human_Phenotype_Ontology:HP:0040083,MedGen:C0427144. Review status: criteria provided, single submitter.