A: The variant NC_000020.11:g.46129125G>T in gene CD40 is classified as 'Uncertain_significance' for Hyper-IgM_syndrome_type_3. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090. Review status: criteria provided, single submitter.