A: The variant NC_000022.11:g.28734707C>T in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for Hereditary_cancer-predisposing_syndrome|CHEK2-related_cancer_predisposition|Breast_and/or_ovarian_cancer|not_provided|not_specified|Familial_cancer_of_breast. Molecular consequence: SO:0001623: 5_prime_UTR_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MedGen:CN221562|MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, conflicting classifications.