A: The variant NC_000020.11:g.58445500G>C in gene VAPB is classified as 'Benign' for Adult-onset_proximal_spinal_muscular_atrophy,_autosomal_dominant|not_provided|Amyotrophic_lateral_sclerosis_type_8. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008453,MedGen:C1854058,OMIM:182980,Orphanet:209335|MedGen:C3661900|MONDO:MONDO:0012077,MedGen:C1837728,OMIM:608627,Orphanet:803. Review status: criteria provided, multiple submitters, no conflicts.