A: The variant NC_000019.10:g.49188723C>G in gene TRPM4 is classified as 'Uncertain_significance' for Sudden_cardiac_death|Progressive_familial_heart_block_type_IB|Cardiovascular_phenotype. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: EFO:EFO_0004278,Human_Phenotype_Ontology:HP:0001645,Human_Phenotype_Ontology:HP:0005161,MeSH:D016757,MedGen:C0085298|MONDO:MONDO:0011474,MedGen:C1970298,OMIM:604559,Orphanet:871|MedGen:CN230736. Review status: criteria provided, multiple submitters, no conflicts.