A: The variant NC_000019.10:g.49210303del in gene TRPM4 is classified as 'Uncertain_significance' for Progressive_familial_heart_block_type_IB. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0011474,MedGen:C1970298,OMIM:604559,Orphanet:871. Review status: criteria provided, single submitter.