A: The variant NC_000019.10:g.18784322G>A in gene COMP is classified as 'Benign/Likely_benign' for not_provided|Connective_tissue_disorder|Pseudoachondroplastic_spondyloepiphyseal_dysplasia_syndrome|Multiple_epiphyseal_dysplasia_type_1. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0003900,MedGen:C0009782|MONDO:MONDO:0008322,MedGen:C0410538,OMIM:177170,Orphanet:750|MONDO:MONDO:0007561,MedGen:C1838280,OMIM:132400,Orphanet:93308. Review status: criteria provided, multiple submitters, no conflicts.