A: The variant NC_000022.11:g.41523901A>C in gene ACO2 is classified as 'Uncertain_significance' for Optic_atrophy_9. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014571,MedGen:C4225384,OMIM:616289. Review status: criteria provided, single submitter.