A: The variant NC_000020.11:g.48971258C>T in gene ARFGEF2 is classified as 'Conflicting_classifications_of_pathogenicity' for Periventricular_heterotopia_with_microcephaly,_autosomal_recessive|not_provided|ARFGEF2-related_disorder. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011966,MedGen:C1842563,OMIM:608097,Orphanet:2149|MedGen:C3661900|.. Review status: criteria provided, conflicting classifications.