A: The variant NC_000022.11:g.28712019T>C in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for CHEK2-related_cancer_predisposition|Familial_cancer_of_breast|Colorectal_cancer|Prostate_cancer|Bone_osteosarcoma|Hereditary_breast_ovarian_cancer_syndrome|Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, multiple submitters, no conflicts.