A: The variant NC_000022.11:g.28725338T>C in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Hereditary_cancer-predisposing_syndrome|CHEK2-related_disorder|CHEK2-related_cancer_predisposition|not_provided|Inherited_breast_cancer_and_ovarian_cancer|Predisposition_to_cancer|Malignant_tumor_of_breast|Breast_and/or_ovarian_cancer|Familial_cancer_of_breast|Hereditary_breast_ovarian_cancer_syndrome|Bone_osteosarcoma|Familial_prostate_cancer|Breast_cancer,_susceptibility_to|Prostate_cancer_susceptibility. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|.|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MedGen:C3661900|.|.|MONDO:MONDO:0007254,MedGen:C0006142|MedGen:CN221562|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MedGen:C3469522|MedGen:C3469524. Review status: criteria provided, multiple submitters, no conflicts.