A: The variant NC_000022.11:g.20991678C>T in gene LZTR1 is classified as 'Pathogenic' for RASopathy|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|not_provided|LZTR1-related_disorder|Noonan_syndrome_10. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|MedGen:C3661900|.|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648. Review status: reviewed by expert panel.