A: The variant NC_000022.11:g.50084725C>A in gene MLC1 is classified as 'Conflicting_classifications_of_pathogenicity' for Abnormality_of_the_nervous_system|Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1|not_provided|Megalencephalic_leukoencephalopathy_with_subcortical_cysts. Molecular consequence: SO:0001575: splice_donor_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000707,Human_Phenotype_Ontology:HP:0001333,Human_Phenotype_Ontology:HP:0006987,MONDO:MONDO:0002320,MedGen:C0497552|MONDO:MONDO:0024555,MedGen:C5779875,OMIM:604004,Orphanet:2478|MedGen:C3661900|MONDO:MONDO:0011391,MedGen:C1858854,Orphanet:2478. Review status: criteria provided, conflicting classifications.