A: The variant NC_000022.11:g.28724661_28727169dup in gene CHEK2 is classified as 'Likely_pathogenic' for Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001574: splice_acceptor_variant,SO:0001575: splice_donor_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, single submitter.