A: The variant NC_000019.10:g.45550852C>T in gene OPA3 is classified as 'Uncertain_significance' for 3-Methylglutaconic_aciduria_type_3|Optic_atrophy_3. Molecular consequence: SO:0001624: 3_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009787,MedGen:C0574084,OMIM:258501,Orphanet:67047|MONDO:MONDO:0008133,MedGen:C1833809,OMIM:165300,Orphanet:67036. Review status: criteria provided, single submitter.