A: The variant NC_000019.10:g.38500642C>T in gene RYR1 is classified as 'Pathogenic|drug_response' for Congenital_multicore_myopathy_with_external_ophthalmoplegia|RYR1-related_disorder|desflurane_response_-_Toxicity|enflurane_response_-_Toxicity|halothane_response_-_Toxicity|succinylcholine_response_-_Toxicity|isoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|sevoflurane_response_-_Toxicity|RYR1-related_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|Malignant_hyperthermia_of_anesthesia|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|MedGen:CN239331|.|.|.|.|.|.|.|MONDO:MONDO:0100150,MedGen:CN305348|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|MedGen:C3661900. Review status: reviewed by expert panel.