A: The variant NC_000021.9:g.43059237C>G in gene CBS is classified as 'Uncertain_significance' for HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3150344. Review status: criteria provided, single submitter.