A: The variant NC_000020.11:g.45892875del in gene CTSA is classified as 'Likely_pathogenic' for Non-immune_hydrops_fetalis|Combined_deficiency_of_sialidase_AND_beta_galactosidase. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0001790,MONDO:MONDO:0009369,MedGen:C0455988,OMIM:236750,Orphanet:363999|MONDO:MONDO:0009737,MedGen:C0268233,OMIM:256540,Orphanet:351. Review status: criteria provided, single submitter.