A: The variant NC_000020.11:g.58891850dup in gene GNAS is classified as 'Likely_pathogenic' for Pseudohypoparathyroidism_type_1C|Pseudohypoparathyroidism_type_I_A|Pseudohypoparathyroidism_type_1B|Pseudopseudohypoparathyroidism|Progressive_osseous_heteroplasia. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0012911,MedGen:C2932716,OMIM:612462,Orphanet:79444|MONDO:MONDO:0007078,MedGen:C3494506,OMIM:103580,Orphanet:79443|MONDO:MONDO:0011301,MedGen:C1864100,OMIM:603233,Orphanet:94089|MONDO:MONDO:0012912,MedGen:C0033835,OMIM:612463,Orphanet:79445|Human_Phenotype_Ontology:HP:0025027,MONDO:MONDO:0008153,MedGen:C0334041,OMIM:166350,Orphanet:2762. Review status: criteria provided, single submitter.