A: The variant NC_000022.11:g.28699894del in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Breast_and/or_ovarian_cancer|Hereditary_cancer-predisposing_syndrome|not_provided|Familial_cancer_of_breast|Hereditary_breast_ovarian_cancer_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MedGen:CN221562|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145. Review status: criteria provided, multiple submitters, no conflicts.