A: The variant NC_000023.11:g.13716057_13716061del in gene TRAPPC2 is classified as 'Pathogenic' for Hereditary_spastic_paraplegia_4|not_provided|Spondyloepiphyseal_dysplasia_tarda. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0008438,MedGen:C1866855,OMIM:182601,Orphanet:100985|MedGen:C3661900|MONDO:MONDO:0019667,MedGen:CN033239,Orphanet:93284. Review status: criteria provided, multiple submitters, no conflicts.