A: The variant NC_000019.10:g.50406326T>A in gene POLD1 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome|not_provided|Colorectal_cancer,_susceptibility_to,_10. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460. Review status: criteria provided, multiple submitters, no conflicts.