A: The variant NC_000019.10:g.48234492dup in gene CARD8 is classified as 'Uncertain_significance' for CARD8-related_disorder. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Duplication. Disease database links: .. Review status: no assertion criteria provided.