A: The variant NC_000021.9:g.31667359T>C in gene SOD1 is classified as 'Pathogenic/Likely_pathogenic' for Motor_neuron_disease|Amyotrophic_lateral_sclerosis_type_1|not_provided|SOD1-related_disorder|Spastic_tetraplegia_and_axial_hypotonia,_progressive. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0020128,MedGen:C0085084,Orphanet:98503|MONDO:MONDO:0007103,MedGen:C1862939,OMIM:105400,Orphanet:803|MedGen:C3661900|.|MONDO:MONDO:0032828,MedGen:C5231422,OMIM:618598. Review status: criteria provided, multiple submitters, no conflicts.