A: The variant NC_000021.9:g.26170776C>G in gene APP is classified as 'Likely_benign' for not_provided|Early-onset_autosomal_dominant_Alzheimer_disease. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0015140,MedGen:CN043596,Orphanet:1020. Review status: criteria provided, multiple submitters, no conflicts.