A: The variant NC_000022.11:g.20709924_20709927del in gene PI4KA is classified as 'Pathogenic' for Spastic_paraplegia_84,_autosomal_recessive|Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0030482,MedGen:C5562025,OMIM:619621,Orphanet:631079|MONDO:MONDO:0014679,MedGen:C4225295,OMIM:616531|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.