A: The variant NC_000019.10:g.42224882A>C in gene ZNF526 is classified as 'Likely_pathogenic' for not_provided|Dentici-Novelli_neurodevelopmental_syndrome|Pulmonic_stenosis|Noonan-like_facies|Intellectual_disability. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0859251,MedGen:C5676987,OMIM:619877|Human_Phenotype_Ontology:HP:0001642,MONDO:MONDO:0009938,MedGen:C1956257,OMIM:265500,Orphanet:3189|MedGen:CN228297|Human_Phenotype_Ontology:HP:0000730,Human_Phenotype_Ontology:HP:0001249,Human_Phenotype_Ontology:HP:0001267,Human_Phenotype_Ontology:HP:0001286,Human_Phenotype_Ontology:HP:0002122,Human_Phenotype_Ontology:HP:0002192,Human_Phenotype_Ontology:HP:0002316,Human_Phenotype_Ontology:HP:0002382,Human_Phenotype_Ontology:HP:0002386,Human_Phenotype_Ontology:HP:0002402,Human_Phenotype_Ontology:HP:0002458,Human_Phenotype_Ontology:HP:0002482,Human_Phenotype_Ontology:HP:0002499,Human_Phenotype_Ontology:HP:0002543,Human_Phenotype_Ontology:HP:0003767,Human_Phenotype_Ontology:HP:0006833,Human_Phenotype_Ontology:HP:0007154,Human_Phenotype_Ontology:HP:0007176,Human_Phenotype_Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756. Review status: criteria provided, single submitter.