A: The variant NC_000022.11:g.19962740G>T in gene COMT is classified as 'Uncertain_significance' for Schizophrenia,_susceptibility_to|Tramadol_response|22q11.2_deletion_syndrome. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0100182,MedGen:C2675945|MedGen:CN078023|MONDO:MONDO:0018923,MedGen:CN294181,Orphanet:567. Review status: criteria provided, single submitter.