A: The variant NC_000019.10:g.45493261dup in gene RTN2 is classified as 'Conflicting_classifications_of_pathogenicity' for Spastic_paraplegia|Hereditary_spastic_paraplegia_12. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Duplication. Disease database links: Human_Phenotype_Ontology:HP:0001258,Human_Phenotype_Ontology:HP:0007062,Human_Phenotype_Ontology:HP:0007124,Human_Phenotype_Ontology:HP:0007216,MedGen:C0037772|MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993. Review status: criteria provided, conflicting classifications.