A: The variant NC_000019.10:g.38566986G>C in gene RYR1 is classified as 'Benign' for Malignant_hyperthermia,_susceptibility_to,_1|King_Denborough_syndrome|Central_core_myopathy|Congenital_multicore_myopathy_with_external_ophthalmoplegia|Congenital_myopathy_with_fiber_type_disproportion|not_provided|Myopathy,_progressive_axial_with_cataracts|RYR1-related_disorder|Generalized_muscle_weakness|Congenital_muscular_dystrophy|Congenital_hip_dislocation|EMG:_myopathic_abnormalities|Malignant_hyperthermia_of_anesthesia|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0020485,MedGen:C1840365,OMIM:619542|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MedGen:C3661900|MedGen:CN221568|MedGen:CN239331|Human_Phenotype_Ontology:HP:0003324,Human_Phenotype_Ontology:HP:0003686,Human_Phenotype_Ontology:HP:0003723,MedGen:C0746674|Human_Phenotype_Ontology:HP:0003741,Human_Phenotype_Ontology:HP:0003793,MONDO:MONDO:0019950,MedGen:C0699743,Orphanet:97242|Human_Phenotype_Ontology:HP:0001374,MedGen:C0019555|Human_Phenotype_Ontology:HP:0003322,Human_Phenotype_Ontology:HP:0003458,Human_Phenotype_Ontology:HP:0003711,Human_Phenotype_Ontology:HP:0009021,MedGen:C4021726|Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|MedGen:CN169374. Review status: reviewed by expert panel.