A: The variant NC_000022.11:g.50679152T>C in gene SHANK3 is classified as 'Benign' for Phelan-McDermid_syndrome|not_specified|not_provided|Inborn_genetic_diseases. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MedGen:CN169374|MedGen:C3661900|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.