A: The variant NC_000019.10:g.45485491C>T in gene RTN2 is classified as 'Uncertain_significance' for Spastic_paraplegia,_autosomal_dominant. Molecular consequence: SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C0751602. Review status: criteria provided, single submitter.