A: The variant NC_000022.11:g.50697277dup in gene SHANK3 is classified as 'Benign/Likely_benign' for Phelan-McDermid_syndrome|not_provided|not_specified. Molecular consequence: SO:0001627: intron_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MedGen:C3661900|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.