A: The variant NC_000022.11:g.46355524dup in gene TRMU is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins|Aminoglycoside-induced_deafness. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: MedGen:C3661900|MONDO:MONDO:0013111,MedGen:C3278664,OMIM:613070,Orphanet:217371|MONDO:MONDO:0010799,MedGen:C1838854,OMIM:580000,Orphanet:168609. Review status: criteria provided, conflicting classifications.