A: The variant NC_000019.10:g.45485716C>T in gene RTN2 is classified as 'Conflicting_classifications_of_pathogenicity' for Hereditary_spastic_paraplegia_12|Inborn_genetic_diseases|Spastic_paraplegia|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993|MeSH:D030342,MedGen:C0950123|Human_Phenotype_Ontology:HP:0001258,Human_Phenotype_Ontology:HP:0007062,Human_Phenotype_Ontology:HP:0007124,Human_Phenotype_Ontology:HP:0007216,MedGen:C0037772|MedGen:C3661900. Review status: criteria provided, conflicting classifications.