A: The variant NC_000022.11:g.42627674G>A in gene CYB5R3 is classified as 'Pathogenic' for METHEMOGLOBINEMIA,_TYPE_II|Deficiency_of_cytochrome-b5_reductase|not_provided. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C2749560|MONDO:MONDO:0009606,MedGen:C0268193,OMIM:250800,Orphanet:621|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.