A: The variant NC_000019.10:g.15160819G>A in gene NOTCH3 is classified as 'Benign/Likely_benign' for not_specified|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|NOTCH3-related_disorder|not_provided|Myofibromatosis,_infantile,_2. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|.|MedGen:C3661900|MONDO:MONDO:0014122,MedGen:C3809084,OMIM:615293,Orphanet:2591. Review status: criteria provided, multiple submitters, no conflicts.