A: The variant NC_000022.11:g.42631431C>T in gene CYB5R3 is classified as 'Likely_pathogenic' for METHEMOGLOBINEMIA,_TYPE_I|not_provided|CYB5R3-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C2749559|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.