A: The variant NC_000021.9:g.36937301_36937317delinsCCTTAATCTCAGGCTTAATCTCAAGCAA in gene HLCS is classified as 'Likely_pathogenic' for Holocarboxylase_synthetase_deficiency|not_provided. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: Indel. Disease database links: MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.