A: The variant NC_000019.10:g.29702767dup in gene C19orf12 is classified as 'Pathogenic/Likely_pathogenic' for Hereditary_spastic_paraplegia_43|Abnormal_central_motor_function|not_provided|Neurodegeneration_with_brain_iron_accumulation_4. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0014024,MedGen:C2680446,OMIM:615043,Orphanet:320370|Human_Phenotype_Ontology:HP:0011442,MedGen:C4023354|MedGen:C3661900|MONDO:MONDO:0013674,MedGen:C3280371,OMIM:614298,Orphanet:289560. Review status: criteria provided, multiple submitters, no conflicts.