A: The variant NC_000019.10:g.17842498_17842499del in gene JAK3 is classified as 'Pathogenic' for T-B+_severe_combined_immunodeficiency_due_to_JAK3_deficiency|Severe_combined_immunodeficiency_disease|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0010938,MedGen:C1833275,OMIM:600802,Orphanet:35078|Human_Phenotype_Ontology:HP:0004430,MONDO:MONDO:0015974,MeSH:D016511,MedGen:C0085110,Orphanet:183660|MedGen:C3661900. Review status: reviewed by expert panel.