A: The variant NC_000022.11:g.21799100G>A in gene MAPK1 is classified as 'Pathogenic' for Heart,_malformation_of|Macrocephaly|Abnormal_facial_shape|Specific_learning_disability|Atypical_behavior|Noonan_syndrome_13|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009327,MeSH:D006330,MedGen:C0018798,OMIM:140500,OMIM:234750|Human_Phenotype_Ontology:HP:0000256,Human_Phenotype_Ontology:HP:0005491,Human_Phenotype_Ontology:HP:0005496,Human_Phenotype_Ontology:HP:0200135,MedGen:C2243051|Human_Phenotype_Ontology:HP:0001999,Human_Phenotype_Ontology:HP:0002004,Human_Phenotype_Ontology:HP:0002260,Human_Phenotype_Ontology:HP:0004643,Human_Phenotype_Ontology:HP:0004649,Human_Phenotype_Ontology:HP:0004652,Human_Phenotype_Ontology:HP:0004655,Human_Phenotype_Ontology:HP:0004675,Human_Phenotype_Ontology:HP:0005124,MedGen:C0424503|Human_Phenotype_Ontology:HP:0001328,Human_Phenotype_Ontology:HP:0007234,MONDO:MONDO:0016225,MedGen:C4025790,Orphanet:211047|Human_Phenotype_Ontology:HP:0000708,Human_Phenotype_Ontology:HP:0000715,Human_Phenotype_Ontology:HP:0002368,Human_Phenotype_Ontology:HP:0002456,MedGen:C0004941|MONDO:MONDO:0033669,MedGen:C5436773,OMIM:619087|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.