A: The variant NC_000020.11:g.59023745C>G in gene TUBB1 is classified as 'Pathogenic' for Congenital_hypothyroidism. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000851,MONDO:MONDO:0018612,MedGen:C0010308,Orphanet:442. Review status: no assertion criteria provided.