A: The variant NC_000022.11:g.23766215G>A in gene CHCHD10 is classified as 'Uncertain_significance' for Frontotemporal_dementia_and/or_amyotrophic_lateral_sclerosis_2|Autosomal_dominant_mitochondrial_myopathy_with_exercise_intolerance|Lower_motor_neuron_syndrome_with_late-adult_onset. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014395,MedGen:C4014648,OMIM:615911,Orphanet:275872|MONDO:MONDO:0014532,MedGen:C4015513,OMIM:616209,Orphanet:457050|MONDO:MONDO:0014025,MedGen:C3554398,OMIM:615048,Orphanet:276435. Review status: criteria provided, single submitter.