A: The variant NC_000019.10:g.38490223G>A in gene RYR1 is classified as 'Uncertain_significance' for RYR1-related_disorder|not_provided|Malignant_hyperthermia,_susceptibility_to,_1|Multiminicore_myopathy|Central_core_myopathy|Congenital_myopathy_with_fiber_type_disproportion|Myopathy,_RYR1-associated. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN239331|MedGen:C3661900|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0018948,MedGen:C0270962,Orphanet:598|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MedGen:CN221567. Review status: criteria provided, multiple submitters, no conflicts.