A: The variant NC_000022.11:g.41141196G>C in gene EP300 is classified as 'Uncertain_significance' for Epileptic_encephalopathy|Corpus_callosum,_agenesis_of|Microcephaly. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0200134,MedGen:C0543888|Human_Phenotype_Ontology:HP:0001274,Human_Phenotype_Ontology:HP:0006800,MONDO:MONDO:0009022,MedGen:C0175754,OMIM:217990,Orphanet:200|Human_Phenotype_Ontology:HP:0000252,Human_Phenotype_Ontology:HP:0001366,Human_Phenotype_Ontology:HP:0005485,Human_Phenotype_Ontology:HP:0005489,Human_Phenotype_Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563. Review status: criteria provided, single submitter.