A: The variant NC_000023.11:g.8533023T>C in gene ANOS1 is classified as 'Conflicting_classifications_of_pathogenicity' for Hypogonadotropic_hypogonadism_1_with_or_without_anosmia|not_specified|Amenorrhea. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010635,MedGen:C1563719,OMIM:308700,Orphanet:478|MedGen:CN169374|Human_Phenotype_Ontology:HP:0000141,MONDO:MONDO:0001836,MedGen:C0002453. Review status: criteria provided, conflicting classifications.