A: The variant NC_000022.11:g.19963713C>G in gene COMT is classified as 'Uncertain_significance' for Panic_disorder_1|Schizophrenia. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008187,MedGen:C1868649,OMIM:167870|Human_Phenotype_Ontology:HP:0100753,MONDO:MONDO:0005090,MeSH:D012559,MedGen:C0036341,OMIM:181500. Review status: criteria provided, single submitter.