A: The variant NC_000019.10:g.50408782dup in gene POLD1 is classified as 'Uncertain_significance' for Familial_colorectal_cancer_type_X|Polymerase_proofreading-related_adenomatous_polyposis. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0018604,MedGen:C3896578,Orphanet:440437|MONDO:MONDO:0018653,MedGen:C0130294,Orphanet:447877. Review status: criteria provided, single submitter.