A: The variant NC_000021.9:g.26170806C>A in gene APP is classified as 'Uncertain_significance' for Early-onset_autosomal_dominant_Alzheimer_disease. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015140,MedGen:CN043596,Orphanet:1020. Review status: criteria provided, single submitter.