A: The variant NC_000019.10:g.15185580G>A in gene NOTCH3 is classified as 'Conflicting_classifications_of_pathogenicity' for Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|Lateral_meningocele_syndrome|Myofibromatosis,_infantile,_2|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|MONDO:MONDO:0007537,MedGen:C1851710,OMIM:130720,Orphanet:2789|MONDO:MONDO:0014122,MedGen:C3809084,OMIM:615293,Orphanet:2591|MedGen:C3661900. Review status: criteria provided, conflicting classifications.