A: The variant NC_000020.11:g.25407773C>G in gene GINS1 is classified as 'Uncertain_significance' for Combined_immunodeficiency_due_to_GINS1_deficiency|not_provided. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0044725,MedGen:C5568132,OMIM:617827,Orphanet:505227|MedGen:C3661900. Review status: criteria provided, single submitter.