A: The variant NC_000019.10:g.35648282A>G in gene COX6B1 is classified as 'Uncertain_significance' for Mitochondrial_complex_IV_deficiency,_nuclear_type_1. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700250,MedGen:C5435656,OMIM:220110. Review status: criteria provided, single submitter.