A: The variant NC_000020.11:g.35437958G>T in gene GDF5 is classified as 'Uncertain_significance' for Acromesomelic_dysplasia_2B|Acromesomelic_dysplasia|Chondrodysplasia|Symphalangism-brachydactyly_syndrome|Brachydactyly. Molecular consequence: SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009231,MedGen:C1856738,OMIM:228900,Orphanet:2639|MONDO:MONDO:0019696,MedGen:C5235036,OMIM:PS602875,Orphanet:93437|MONDO:MONDO:0022723,MedGen:C0343284|MONDO:MONDO:0008519,MedGen:C0342282,OMIM:186500,Orphanet:3237|Human_Phenotype_Ontology:HP:0001156,Human_Phenotype_Ontology:HP:0001189,Human_Phenotype_Ontology:HP:0001201,Human_Phenotype_Ontology:HP:0005630,Human_Phenotype_Ontology:HP:0005657,Human_Phenotype_Ontology:HP:0005727,Human_Phenotype_Ontology:HP:0006017,Human_Phenotype_Ontology:HP:0006128,Human_Phenotype_Ontology:HP:0100667,MONDO:MONDO:0021004,MedGen:C0221357. Review status: criteria provided, single submitter.