A: The variant NC_000019.10:g.15192490C>T in gene NOTCH3 is classified as 'Pathogenic' for not_provided|Stroke_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0001297,Human_Phenotype_Ontology:HP:0002452,MONDO:MONDO:0005098,MeSH:D020521,MedGen:C0038454. Review status: criteria provided, single submitter.