A: The variant NC_000022.11:g.20997251T>G in gene LZTR1 is classified as 'Uncertain_significance' for not_provided|Noonan_syndrome_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0008104,MedGen:C4551602,OMIM:163950,Orphanet:648. Review status: criteria provided, multiple submitters, no conflicts.