A: The variant NC_000022.11:g.28703500C>T in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for Hereditary_cancer-predisposing_syndrome|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, conflicting classifications.