A: The variant NC_000019.10:g.15192140G>A in gene NOTCH3 is classified as 'Benign' for NOTCH3-related_disorder|Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.