A: The variant NC_000019.10:g.38457583_38457587del in gene RYR1 is classified as 'Pathogenic' for Myopathy|RYR1-related_disorder. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0003198,Human_Phenotype_Ontology:HP:0003569,Human_Phenotype_Ontology:HP:0003705,Human_Phenotype_Ontology:HP:0003742,Human_Phenotype_Ontology:HP:0003802,MONDO:MONDO:0005336,MeSH:D009135,MedGen:C0026848|MedGen:CN239331. Review status: criteria provided, multiple submitters, no conflicts.