A: The variant NC_000020.11:g.4699780A>G in gene PRNP is classified as 'Pathogenic' for Gerstmann-Straussler-Scheinker_syndrome|Spongiform_encephalopathy_with_neuropsychiatric_features. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007656,MedGen:C0017495,OMIM:137440,Orphanet:356|MONDO:MONDO:0011703,MedGen:C1847650,OMIM:606688. Review status: no assertion criteria provided.