A: The variant NC_000019.10:g.42250362T>C in gene ERF is classified as 'Uncertain_significance' for Craniosynostosis_4. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0004443,Human_Phenotype_Ontology:HP:0004486,MONDO:MONDO:0010929,MedGen:C1833340,OMIM:600775. Review status: criteria provided, single submitter.