A: The variant NC_000019.10:g.38448516_38448540del in gene RYR1 is classified as 'Uncertain_significance' for Malignant_hyperthermia,_susceptibility_to,_1|Neuromuscular_disease|not_specified|RYR1-related_disorder|not_provided. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0019056,MeSH:D009468,MedGen:C0027868,Orphanet:68381|MedGen:CN169374|MedGen:CN239331|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.