A: The variant NC_000020.11:g.41101297G>A in gene TOP1 is classified as 'Pathogenic' for DNA_topoisomerase_I,_camptothecin-resistant. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C4016020. Review status: no assertion criteria provided.