A: The variant NC_000020.11:g.23049098A>C in gene THBD is classified as 'Uncertain_significance' for not_provided|Atypical_hemolytic-uremic_syndrome_with_thrombomodulin_anomaly|Thrombomodulin-related_bleeding_disorder|Thrombocytopenia|Abnormal_bleeding. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0013044,MedGen:C2752036,OMIM:612926|MONDO:MONDO:0013775,MedGen:C3280976,OMIM:614486,Orphanet:436169|Human_Phenotype_Ontology:HP:0001873,Human_Phenotype_Ontology:HP:0001906,Human_Phenotype_Ontology:HP:0004838,Human_Phenotype_Ontology:HP:0008175,Human_Phenotype_Ontology:HP:0008268,Human_Phenotype_Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034|Human_Phenotype_Ontology:HP:0001892,Human_Phenotype_Ontology:HP:0004830,Human_Phenotype_Ontology:HP:0004834,Human_Phenotype_Ontology:HP:0004849,Human_Phenotype_Ontology:HP:0004862,Human_Phenotype_Ontology:HP:0004865,Human_Phenotype_Ontology:HP:0008183,MedGen:C1458140. Review status: criteria provided, multiple submitters, no conflicts.