A: The variant NC_000019.10:g.38580440G>A in gene RYR1 is classified as 'Conflicting_classifications_of_pathogenicity|drug_response' for Central_core_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|halothane_response_-_Toxicity|desflurane_response_-_Toxicity|enflurane_response_-_Toxicity|Malignant_hyperthermia_of_anesthesia|RYR1-related_disorder|RYR1-related_myopathy|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|.|.|.|.|.|.|.|Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|MedGen:CN239331|MONDO:MONDO:0100150,MedGen:CN305348|MedGen:C3661900. Review status: reviewed by expert panel.