A: The variant NC_000019.10:g.49016546C>G in gene LHB is classified as 'Pathogenic' for Isolated_lutropin_deficiency. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009223,MedGen:C0271582,OMIM:228300,Orphanet:325448. Review status: no assertion criteria provided.