A: The variant NC_000019.10:g.45485753G>A in gene RTN2 is classified as 'Benign/Likely_benign' for not_specified|Spastic_paraplegia,_autosomal_dominant|Spastic_paraplegia|not_provided|Hereditary_spastic_paraplegia. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MedGen:C0751602|Human_Phenotype_Ontology:HP:0001258,Human_Phenotype_Ontology:HP:0007062,Human_Phenotype_Ontology:HP:0007124,Human_Phenotype_Ontology:HP:0007216,MedGen:C0037772|MedGen:C3661900|MONDO:MONDO:0019064,MedGen:C0037773,OMIM:PS303350,Orphanet:685. Review status: criteria provided, multiple submitters, no conflicts.