A: The variant NC_000019.10:g.45494937C>A in gene RTN2 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Hereditary_spastic_paraplegia_12|Spastic_paraplegia. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993|Human_Phenotype_Ontology:HP:0001258,Human_Phenotype_Ontology:HP:0007062,Human_Phenotype_Ontology:HP:0007124,Human_Phenotype_Ontology:HP:0007216,MedGen:C0037772. Review status: criteria provided, multiple submitters, no conflicts.