A: The variant NC_000022.11:g.46337792_46337793del in gene TRMU is classified as 'Pathogenic/Likely_pathogenic' for Aminoglycoside-induced_deafness|Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins|not_provided. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0010799,MedGen:C1838854,OMIM:580000,Orphanet:168609|MONDO:MONDO:0013111,MedGen:C3278664,OMIM:613070,Orphanet:217371|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.