A: The variant NC_000022.11:g.28725346C>A in gene CHEK2 is classified as 'Uncertain_significance' for not_provided|Familial_cancer_of_breast|Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, multiple submitters, no conflicts.