A: The variant NC_000019.10:g.41352912G>A in gene TGFB1 is classified as 'Likely_pathogenic' for Inflammatory_bowel_disease,_immunodeficiency,_and_encephalopathy|Encephalopathy|IL10-related_early-onset_inflammatory_bowel_disease. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032601,MedGen:C4748708,OMIM:618213,Orphanet:565788|Human_Phenotype_Ontology:HP:0001298,MedGen:C0085584|MONDO:MONDO:0016542,MedGen:C4749850,Orphanet:238569. Review status: criteria provided, single submitter.