A: The variant NC_000020.11:g.59023981C>T in gene TUBB1 is classified as 'Uncertain_significance' for Macrothrombocytopenia|Macrothrombocytopenia,_isolated,_1,_autosomal_dominant|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0040185,MedGen:C2751260|MONDO:MONDO:0800047,MedGen:C5676892,OMIM:613112,Orphanet:140957|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.