A: The variant NC_000022.11:g.50627338_50627339delinsAG in gene ARSA is classified as 'Pathogenic' for not_provided|METACHROMATIC_LEUKODYSTROPHY,_SEVERE. Molecular consequence: SO:0001583: missense_variant. Variant type: Indel. Disease database links: MedGen:C3661900|MedGen:C4017094. Review status: no assertion criteria provided.