A: The variant NC_000019.10:g.50401894G>A in gene POLD1 is classified as 'Benign/Likely_benign' for not_specified|Colorectal_cancer,_susceptibility_to,_10|Hereditary_cancer-predisposing_syndrome|not_provided|POLD1-related_disorder|Mandibular_hypoplasia-deafness-progeroid_syndrome|Colon_cancer|Familial_ovarian_cancer. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|.|MONDO:MONDO:0014157,MedGen:C3715192,OMIM:615381,Orphanet:363649|Human_Phenotype_Ontology:HP:0003003,Human_Phenotype_Ontology:HP:0006718,MONDO:MONDO:0021063,MedGen:C0007102|MONDO:MONDO:0016248,MedGen:C5679802,Orphanet:213517. Review status: criteria provided, multiple submitters, no conflicts.