A: The variant NC_000022.11:g.28695800T>G in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Prostate_cancer|CHEK2-related_cancer_predisposition|Hereditary_cancer-predisposing_syndrome|not_provided|Familial_cancer_of_breast|Premature_ovarian_failure|Hereditary_breast_ovarian_cancer_syndrome|Malignant_tumor_of_breast. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0005387,MedGen:C0085215|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0007254,MedGen:C0006142. Review status: criteria provided, multiple submitters, no conflicts.