A: The variant NC_000019.10:g.18156181G>A in gene PIK3R2 is classified as 'Benign/Likely_benign' for Inborn_genetic_diseases|Megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome_1|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0011313,MedGen:C4012727,OMIM:603387,Orphanet:83473|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.