A: The variant NC_000021.9:g.43068617T>G in gene CBS is classified as 'Likely_pathogenic' for Classic_homocystinuria. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394. Review status: criteria provided, single submitter.