A: The variant NC_000019.10:g.38451850C>G in gene RYR1 is classified as 'Uncertain_significance|drug_response' for succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|halothane_response_-_Toxicity|not_specified|enflurane_response_-_Toxicity|desflurane_response_-_Toxicity|RYR1-related_disorder|not_provided|Central_core_myopathy|Malignant_hyperthermia,_susceptibility_to,_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|.|.|.|.|MedGen:CN169374|.|.|MedGen:CN239331|MedGen:C3661900|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423. Review status: reviewed by expert panel.