A: The variant NC_000019.10:g.18156199C>T in gene PIK3R2 is classified as 'Likely_benign' for Overgrowth_syndrome_and/or_cerebral_malformations_due_to_abnormalities_in_MTOR_pathway_genes. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0100283,MedGen:CN300503. Review status: reviewed by expert panel.