A: The variant NC_000019.10:g.45352274T>G in gene ERCC2 is classified as 'Likely_pathogenic' for not_provided|Cerebrooculofacioskeletal_syndrome_2|Xeroderma_pigmentosum,_group_D|Trichothiodystrophy_1,_photosensitive. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0012553,MedGen:C1853102,OMIM:610756|MONDO:MONDO:0010212,MedGen:C0268138,OMIM:278730|MONDO:MONDO:0011125,MedGen:C1866504,OMIM:601675,Orphanet:33364,Orphanet:670. Review status: criteria provided, multiple submitters, no conflicts.