A: The variant NC_000019.10:g.15200845G>A in gene NOTCH3 is classified as 'Uncertain_significance' for not_provided|Inborn_genetic_diseases|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136. Review status: criteria provided, multiple submitters, no conflicts.