A: The variant NC_000019.10:g.15192134G>A in gene NOTCH3 is classified as 'Pathogenic' for Myofibromatosis,_infantile,_2|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|Lateral_meningocele_syndrome|Migraine_without_aura|Stroke_disorder|not_provided|NOTCH3-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014122,MedGen:C3809084,OMIM:615293,Orphanet:2591|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|MONDO:MONDO:0007537,MedGen:C1851710,OMIM:130720,Orphanet:2789|Human_Phenotype_Ontology:HP:0002083,MONDO:MONDO:0100431,MedGen:C0338480|Human_Phenotype_Ontology:HP:0001297,Human_Phenotype_Ontology:HP:0002452,MONDO:MONDO:0005098,MeSH:D020521,MedGen:C0038454|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.