A: The variant NC_000019.10:g.38499655G>A in gene RYR1 is classified as 'Pathogenic|drug_response' for enflurane_response_-_Toxicity|RYR1-related_disorder|not_provided|Malignant_hyperthermia,_susceptibility_to,_1|desflurane_response_-_Toxicity|succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|halothane_response_-_Toxicity. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MedGen:CN239331|MedGen:C3661900|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|.|.|.|.|.|.. Review status: reviewed by expert panel.