A: The variant NC_000020.11:g.63350216G>C in gene CHRNA4 is classified as 'Uncertain_significance' for Autosomal_dominant_nocturnal_frontal_lobe_epilepsy_1|Tobacco_addiction,_susceptibility_to. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010899,MedGen:C1838049,OMIM:600513,Orphanet:98784|MONDO:MONDO:0100460,MedGen:C1861063,OMIM:188890. Review status: criteria provided, single submitter.