A: The variant NC_000022.11:g.28734398C>A in gene CHEK2 is classified as 'Uncertain_significance' for CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_prostate_cancer|Familial_cancer_of_breast|not_provided. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.