A: The variant NC_000022.11:g.20996965del in gene LZTR1 is classified as 'Conflicting_classifications_of_pathogenicity' for Noonan_syndrome_and_Noonan-related_syndrome|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0020297,MedGen:C5681679,Orphanet:98733|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736. Review status: criteria provided, conflicting classifications.