A: The variant NC_000019.10:g.19197253_19197254del in gene RFXANK is classified as 'Likely_pathogenic' for MHC_class_II_deficiency|MHC_class_II_deficiency_2. Molecular consequence: SO:0001575: splice_donor_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0008855,MedGen:C5447452,OMIM:PS209920,Orphanet:572|MONDO:MONDO:0971013,MedGen:C1859535,OMIM:620815. Review status: criteria provided, multiple submitters, no conflicts.