A: The variant NC_000019.10:g.38586126C>A in gene RYR1 is classified as 'Likely_pathogenic' for Malignant_hyperthermia_of_anesthesia. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423. Review status: criteria provided, single submitter.