A: The variant NC_000022.11:g.28725070C>T in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Predisposition_to_cancer|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_prostate_cancer|Hereditary_nonpolyposis_colon_cancer|not_provided|Familial_cancer_of_breast|Hereditary_cancer-predisposing_syndrome|Breast_carcinoma|Breast_and_colorectal_cancer,_susceptibility_to|Hereditary_breast_ovarian_cancer_syndrome|Malignant_tumor_of_breast. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0018630,MedGen:C1333990,OMIM:PS120435,Orphanet:443909|MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222|MedGen:CN068920|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0007254,MedGen:C0006142. Review status: criteria provided, multiple submitters, no conflicts.