A: The variant NC_000019.10:g.45353112C>T in gene ERCC2 is classified as 'Uncertain_significance' for not_specified|not_provided|Xeroderma_pigmentosum|Xeroderma_pigmentosum,_group_D. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MedGen:C3661900|MONDO:MONDO:0019600,MedGen:C0043346,Orphanet:910|MONDO:MONDO:0010212,MedGen:C0268138,OMIM:278730. Review status: criteria provided, multiple submitters, no conflicts. Oncogenicity: ONC: Likely_oncogenic, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005872039