A: The variant NC_000021.9:g.42388436G>T in gene TMPRSS3 is classified as 'Pathogenic/Likely_pathogenic' for Hearing_impairment|not_provided|Rare_genetic_deafness|TMPRSS3-related_disorder|Autosomal_recessive_nonsyndromic_hearing_loss_8|Nonsyndromic_genetic_hearing_loss. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666|MedGen:C3661900|MedGen:C5680250,Orphanet:96210|.|MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636|MONDO:MONDO:0019497,MedGen:C5680182,Orphanet:87884. Review status: criteria provided, multiple submitters, no conflicts.