A: The variant NC_000019.10:g.38452838G>A in gene RYR1 is classified as 'Conflicting_classifications_of_pathogenicity' for Malignant_hyperthermia,_susceptibility_to,_1|Central_core_myopathy|Elevated_circulating_creatine_kinase_concentration|Myalgia|Exercise-induced_myalgia|RYR1-related_disorder|Congenital_myopathy_with_fiber_type_disproportion|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|Human_Phenotype_Ontology:HP:0002147,Human_Phenotype_Ontology:HP:0002906,Human_Phenotype_Ontology:HP:0003078,Human_Phenotype_Ontology:HP:0003236,Human_Phenotype_Ontology:HP:0003525,Human_Phenotype_Ontology:HP:0003531,Human_Phenotype_Ontology:HP:0008164,MONDO:MONDO:0007402,MedGen:C0241005,OMIM:123320|Human_Phenotype_Ontology:HP:0003326,Human_Phenotype_Ontology:HP:0003718,MedGen:C0231528|Human_Phenotype_Ontology:HP:0003738,MedGen:C1850830|MedGen:CN239331|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MedGen:C3661900. Review status: criteria provided, conflicting classifications.