A: The variant NC_000021.9:g.25702257C>T in gene JAM2 is classified as 'Pathogenic' for Basal_ganglia_calcification,_idiopathic,_8,_autosomal_recessive|not_provided|JAM2-related_disorder. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032938,MedGen:C5394199,OMIM:618824|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.