A: The variant NC_000021.9:g.42371980C>T in gene TMPRSS3 is classified as 'Uncertain_significance' for Autosomal_recessive_nonsyndromic_hearing_loss_8. Molecular consequence: SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636. Review status: criteria provided, single submitter.