A: The variant NC_000022.11:g.42623828G>A in gene CYB5R3 is classified as 'Uncertain_significance' for Deficiency_of_cytochrome-b5_reductase. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009606,MedGen:C0268193,OMIM:250800,Orphanet:621. Review status: criteria provided, single submitter.