A: The variant NC_000022.11:g.45503017C>A in gene FBLN1 is classified as 'Uncertain_significance' for not_specified|Synpolydactyly_type_2. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0011984,MedGen:C1842422,OMIM:608180,Orphanet:295197,Orphanet:93403. Review status: criteria provided, multiple submitters, no conflicts.