A: The variant NC_000022.11:g.41524870G>T in gene ACO2 is classified as 'Pathogenic' for not_provided|Optic_atrophy_9. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0014571,MedGen:C4225384,OMIM:616289. Review status: criteria provided, multiple submitters, no conflicts.