A: The variant NC_000020.11:g.46588074C>T in gene SLC13A3 is classified as 'Uncertain_significance' for Leukoencephalopathy,_acute_reversible,_with_increased_urinary_alpha-ketoglutarate|not_specified. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032716,MedGen:C5193068,OMIM:618384,Orphanet:615964|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.