A: The variant NC_000019.10:g.50417250G>A in gene POLD1 is classified as 'Conflicting_classifications_of_pathogenicity' for Hereditary_cancer-predisposing_syndrome|Mandibular_hypoplasia-deafness-progeroid_syndrome|Micrognathia. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0014157,MedGen:C3715192,OMIM:615381,Orphanet:363649|Human_Phenotype_Ontology:HP:0000210,Human_Phenotype_Ontology:HP:0000330,Human_Phenotype_Ontology:HP:0000345,Human_Phenotype_Ontology:HP:0000347,Human_Phenotype_Ontology:HP:0002005,Human_Phenotype_Ontology:HP:0002674,Human_Phenotype_Ontology:HP:0004669,Human_Phenotype_Ontology:HP:0005460,Human_Phenotype_Ontology:HP:0005470,MedGen:C0025990. Review status: criteria provided, conflicting classifications.