A: The variant NC_000022.11:g.50720741G>T in gene SHANK3 is classified as 'Conflicting_classifications_of_pathogenicity' for SHANK3-related_disorder|Inborn_genetic_diseases|Phelan-McDermid_syndrome|Schizophrenia_15|not_specified|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MONDO:MONDO:0013498,MedGen:C3151380,OMIM:613950|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, conflicting classifications.