A: The variant NC_000021.9:g.37486571_37486574delinsGAA in gene DYRK1A is classified as 'Pathogenic' for Intellectual_disability|Microcephaly|Absent_or_delayed_speech_development|Deeply_set_eye|Feeding_difficulties. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Indel. Disease database links: Human_Phenotype_Ontology:HP:0000730,Human_Phenotype_Ontology:HP:0001249,Human_Phenotype_Ontology:HP:0001267,Human_Phenotype_Ontology:HP:0001286,Human_Phenotype_Ontology:HP:0002122,Human_Phenotype_Ontology:HP:0002192,Human_Phenotype_Ontology:HP:0002316,Human_Phenotype_Ontology:HP:0002382,Human_Phenotype_Ontology:HP:0002386,Human_Phenotype_Ontology:HP:0002402,Human_Phenotype_Ontology:HP:0002458,Human_Phenotype_Ontology:HP:0002482,Human_Phenotype_Ontology:HP:0002499,Human_Phenotype_Ontology:HP:0002543,Human_Phenotype_Ontology:HP:0003767,Human_Phenotype_Ontology:HP:0006833,Human_Phenotype_Ontology:HP:0007154,Human_Phenotype_Ontology:HP:0007176,Human_Phenotype_Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756|Human_Phenotype_Ontology:HP:0000252,Human_Phenotype_Ontology:HP:0001366,Human_Phenotype_Ontology:HP:0005485,Human_Phenotype_Ontology:HP:0005489,Human_Phenotype_Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563|MedGen:C3276611|Human_Phenotype_Ontology:HP:0000490,Human_Phenotype_Ontology:HP:0000663,MONDO:MONDO:0001210,MedGen:C0423224|Human_Phenotype_Ontology:HP:0011968,MedGen:C0232466. Review status: criteria provided, single submitter.