A: The variant NC_000021.9:g.46215720T>C in gene LSS is classified as 'Likely_pathogenic' for not_provided|Hypotrichosis_14|Alopecia-intellectual_disability_syndrome_4. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0032649,MedGen:C4748930,OMIM:618275|MONDO:MONDO:0030009,MedGen:C5394241,OMIM:618840. Review status: criteria provided, multiple submitters, no conflicts.