A: The variant NC_000019.10:g.15191974C>T in gene NOTCH3 is classified as 'Pathogenic/Likely_pathogenic' for NOTCH3-related_disorder|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.