A: The variant NC_000022.11:g.50626033T>A in gene ARSA is classified as 'Pathogenic/Likely_pathogenic' for Leukodystrophy|not_provided|METACHROMATIC_LEUKODYSTROPHY,_SEVERE|Metachromatic_leukodystrophy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002415,Human_Phenotype_Ontology:HP:0006926,Human_Phenotype_Ontology:HP:0007079,MONDO:MONDO:0019046,MedGen:C0023520,OMIM:PS312080,Orphanet:68356|MedGen:C3661900|MedGen:C4017094|MONDO:MONDO:0018868,MedGen:C0023522,OMIM:250100,Orphanet:512. Review status: criteria provided, multiple submitters, no conflicts.