A: The variant NC_000021.9:g.39293986C>T in gene BRWD1 is classified as 'Likely_pathogenic' for Premature_ovarian_failure. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0005387,MedGen:C0085215. Review status: criteria provided, single submitter.