A: The variant NC_000022.11:g.20991684G>A in gene LZTR1 is classified as 'Likely_pathogenic' for RASopathy|not_provided|Noonan_syndrome_and_Noonan-related_syndrome|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|LZTR1-related_disorder|Noonan_syndrome_10|LZTR1-related_schwannomatosis|Male_infertility_with_azoospermia_or_oligozoospermia_due_to_single_gene_mutation|Noonan_syndrome_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MedGen:C3661900|MONDO:MONDO:0020297,MedGen:C5681679,Orphanet:98733|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|.|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648|MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921|MedGen:C5681165,Orphanet:399805|MONDO:MONDO:0008104,MedGen:C4551602,OMIM:163950,Orphanet:648. Review status: reviewed by expert panel.