A: The variant NC_000022.11:g.19963684C>G in gene COMT is classified as 'Benign' for not_provided|methamphetamine_use_disorder|Tramadol_response|not_specified. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|.|MedGen:CN078023|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.