A: The variant NC_000022.11:g.28734532C>T in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Breast_and_colorectal_cancer,_susceptibility_to|CHEK2-related_cancer_predisposition|Hereditary_cancer-predisposing_syndrome|Bone_osteosarcoma|Familial_prostate_cancer|CHEK2-related_disorder|Predisposition_to_cancer|Malignant_tumor_of_breast|Breast_and/or_ovarian_cancer|Familial_cancer_of_breast|Hereditary_breast_ovarian_cancer_syndrome|not_specified. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN068920|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|.|.|MONDO:MONDO:0007254,MedGen:C0006142|MedGen:CN221562|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MedGen:CN169374. Review status: criteria provided, conflicting classifications. Oncogenicity: ONC: Oncogenic, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005872051