A: The variant NC_000019.10:g.50402742dup in gene POLD1 is classified as 'Uncertain_significance' for Colorectal_cancer,_susceptibility_to,_10|Familial_colorectal_cancer_type_X|not_provided. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460|MONDO:MONDO:0018604,MedGen:C3896578,Orphanet:440437|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.