A: The variant NC_000020.11:g.32434612_32434634del in gene ASXL1 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Cafe-au-lait_spot|Juvenile_myelomonocytic_leukemia|Bohring-Opitz_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0000957,Human_Phenotype_Ontology:HP:0005601,Human_Phenotype_Ontology:HP:0007454,MedGen:C0221263|Human_Phenotype_Ontology:HP:0012209,MONDO:MONDO:0011908,MedGen:C0349639,OMIM:607785,Orphanet:86834|MONDO:MONDO:0011510,MedGen:C0796232,OMIM:605039,Orphanet:97297. Review status: criteria provided, multiple submitters, no conflicts.