A: The variant NC_000019.10:g.43747633G>A in gene SMG9 is classified as 'Uncertain_significance' for Heart_and_brain_malformation_syndrome. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014833,MedGen:C4310793,OMIM:616920. Review status: criteria provided, single submitter.