A: The variant NC_000021.9:g.44525708C>T in gene TSPEAR is classified as 'Pathogenic' for Ectodermal_dysplasia_14,_hair/tooth_type_with_or_without_hypohidrosis|not_provided. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032584,MedGen:C4748560,OMIM:618180|MedGen:C3661900. Review status: criteria provided, single submitter.