A: The variant NC_000021.9:g.44525648C>T in gene TSPEAR is classified as 'Uncertain_significance' for Autosomal_recessive_nonsyndromic_hearing_loss_98|Ectodermal_dysplasia_14,_hair/tooth_type_with_or_without_hypohidrosis|Tooth_agenesis,_selective,_10. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013929,MedGen:C3553932,OMIM:614861,Orphanet:90636|MONDO:MONDO:0032584,MedGen:C4748560,OMIM:618180|MONDO:MONDO:0859339,MedGen:C5774277,OMIM:620173. Review status: criteria provided, single submitter.