A: The variant NC_000022.11:g.50064175_50064185delinsTGC in gene MLC1 is classified as 'Pathogenic' for Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1|Inborn_genetic_diseases. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Indel. Disease database links: MONDO:MONDO:0024555,MedGen:C5779875,OMIM:604004,Orphanet:2478|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.