A: The variant NC_000020.11:g.5314313del in gene PROKR2 is classified as 'Pathogenic/Likely_pathogenic' for Hypogonadotropic_hypogonadism_2_with_or_without_anosmia|PROKR2-related_disorder|Inborn_genetic_diseases|Hypogonadotropic_hypogonadism_3_with_or_without_anosmia|not_specified|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0007844,MedGen:C1563720,OMIM:147950,Orphanet:478|.|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0009482,MedGen:C3550478,OMIM:244200,Orphanet:478|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.