A: The variant NC_000020.11:g.23049261del in gene THBD is classified as 'Likely_pathogenic' for Atypical_hemolytic-uremic_syndrome_with_thrombomodulin_anomaly|Abnormal_thrombosis. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0013044,MedGen:C2752036,OMIM:612926|Human_Phenotype_Ontology:HP:0001977,MedGen:C4025731. Review status: criteria provided, multiple submitters, no conflicts.