A: The variant NC_000021.9:g.45183413dup in gene ADARB1 is classified as 'Uncertain_significance' for Neurodevelopmental_disorder_with_hypotonia,_microcephaly,_and_seizures. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0030025,MedGen:C5394312,OMIM:618862. Review status: criteria provided, single submitter.