A: The variant NC_000020.11:g.35437467G>T in gene GDF5 is classified as 'Benign/Likely_benign' for not_provided|Multiple_synostoses_syndrome_2|Acromesomelic_dysplasia_2C,_Hunter-Thompson_type|Grebe_syndrome|Acromesomelic_dysplasia_2B|not_specified|Brachydactyly. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0012394,MedGen:C1832708,OMIM:610017,Orphanet:3237|MONDO:MONDO:0008717,MedGen:C2930970,OMIM:201250,Orphanet:968|MONDO:MONDO:0008703,MedGen:C0265260,OMIM:200700,Orphanet:2098|MONDO:MONDO:0009231,MedGen:C1856738,OMIM:228900,Orphanet:2639|MedGen:CN169374|Human_Phenotype_Ontology:HP:0001156,Human_Phenotype_Ontology:HP:0001189,Human_Phenotype_Ontology:HP:0001201,Human_Phenotype_Ontology:HP:0005630,Human_Phenotype_Ontology:HP:0005657,Human_Phenotype_Ontology:HP:0005727,Human_Phenotype_Ontology:HP:0006017,Human_Phenotype_Ontology:HP:0006128,Human_Phenotype_Ontology:HP:0100667,MONDO:MONDO:0021004,MedGen:C0221357. Review status: criteria provided, multiple submitters, no conflicts.