A: The variant NC_000019.10:g.38519366G>T in gene RYR1 is classified as 'Likely_pathogenic' for RYR1-related_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|RYR1-related_disorder. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0100150,MedGen:CN305348|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MedGen:CN239331. Review status: reviewed by expert panel.