A: The variant NC_000021.9:g.33882282C>T in gene ITSN1 is classified as 'Uncertain_significance' for not_provided|Esophageal_atresia/tracheoesophageal_fistula. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0002575,MONDO:MONDO:0008586,MeSH:D014138,MedGen:C0040588,OMIM:189960,Orphanet:1199. Review status: criteria provided, single submitter.