A: The variant NC_000021.9:g.45182607G>C in gene ADARB1 is classified as 'Uncertain_significance' for Neurodevelopmental_disorder_with_hypotonia,_microcephaly,_and_seizures|Syndromic_intellectual_disability. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030025,MedGen:C5394312,OMIM:618862|MONDO:MONDO:0000508,MedGen:C5680525,Orphanet:183763. Review status: criteria provided, single submitter.