A: The variant NC_000019.10:g.42248911T>C in gene ERF is classified as 'Uncertain_significance' for TWIST1-related_craniosynostosis|Inborn_genetic_diseases. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007399,MedGen:C4551902,OMIM:123100,Orphanet:63440|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.