A: The variant NC_000021.9:g.42389921A>T in gene TMPRSS3 is classified as 'Uncertain_significance' for Hearing_loss,_autosomal_recessive. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636. Review status: criteria provided, single submitter.