A: The variant NC_000021.9:g.42383062C>G in gene TMPRSS3 is classified as 'Pathogenic' for not_provided|Hearing_impairment|Autosomal_recessive_nonsyndromic_hearing_loss_8. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666|MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636. Review status: criteria provided, multiple submitters, no conflicts.