A: The variant NC_000019.10:g.35134679A>G in gene LGI4 is classified as 'Pathogenic' for Arthrogryposis_multiplex_congenita_2,_neurogenic_type. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008823,MedGen:C5435650,OMIM:208100,Orphanet:1143. Review status: criteria provided, single submitter.