A: The variant NC_000020.11:g.34413869A>G in gene ITCH is classified as 'Likely_benign' for Syndromic_multisystem_autoimmune_disease_due_to_ITCH_deficiency|not_provided|ITCH-related_disorder. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013245,MedGen:C3150649,OMIM:613385,Orphanet:228426|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.