A: The variant NC_000022.11:g.50721512dup in gene SHANK3 is classified as 'Pathogenic' for not_provided|Inborn_genetic_diseases|Phelan-McDermid_syndrome|Schizophrenia_15|SHANK3-related_disorder|Neurodevelopmental_disorder|Autism_spectrum_disorder. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MedGen:C3661900|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MONDO:MONDO:0013498,MedGen:C3151380,OMIM:613950|.|MONDO:MONDO:0700092,MeSH:D065886,MedGen:C1535926|MONDO:MONDO:0005258,MeSH:D000067877,MedGen:C1510586,Orphanet:106. Review status: criteria provided, multiple submitters, no conflicts.