A: The variant NC_000023.11:g.2953163C>G in gene ARSL is classified as 'Conflicting_classifications_of_pathogenicity' for Coffin-Siris_syndrome_1|not_specified|X-linked_chondrodysplasia_punctata_1|Chondrodysplasia_punctata,_brachytelephalangic,_autosomal|not_provided|ARSL-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007617,MedGen:C3281201,OMIM:135900,Orphanet:1465|MedGen:CN169374|MONDO:MONDO:0010555,MedGen:C3669395,OMIM:302950,Orphanet:79345|MONDO:MONDO:0011238,MedGen:C1844853,OMIM:602497|MedGen:C3661900|.. Review status: criteria provided, conflicting classifications.