A: The variant NC_000019.10:g.45489372dup in gene RTN2 is classified as 'Uncertain_significance' for Hereditary_spastic_paraplegia_12. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993. Review status: criteria provided, single submitter.