A: The variant NC_000020.11:g.1002089_1002092del in gene RSPO4 is classified as 'Pathogenic' for Anonychia. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0001798,Human_Phenotype_Ontology:HP:0007593,Human_Phenotype_Ontology:HP:0008384,MONDO:MONDO:0008798,MedGen:C0265998,OMIM:206800,Orphanet:79143,Orphanet:94150. Review status: criteria provided, single submitter.