A: The variant NC_000020.11:g.58854540C>T in gene GNAS is classified as 'Uncertain_significance' for McCune-Albright_syndrome|Pituitary_adenoma_3,_multiple_types|Pseudohypoparathyroidism_type_1B|Pseudopseudohypoparathyroidism|Progressive_osseous_heteroplasia|ACTH-independent_macronodular_adrenal_hyperplasia_1|Pseudohypoparathyroidism_type_I_A|Pseudohypoparathyroidism_type_1C|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant,SO:0001819: synonymous_variant,SO:0002153: genic_upstream_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018919,MedGen:C0242292,OMIM:174800,Orphanet:562|MONDO:MONDO:0054665,MedGen:C4540135,OMIM:617686|MONDO:MONDO:0011301,MedGen:C1864100,OMIM:603233,Orphanet:94089|MONDO:MONDO:0012912,MedGen:C0033835,OMIM:612463,Orphanet:79445|Human_Phenotype_Ontology:HP:0025027,MONDO:MONDO:0008153,MedGen:C0334041,OMIM:166350,Orphanet:2762|MONDO:MONDO:0020735,MedGen:C1857451,OMIM:219080|MONDO:MONDO:0007078,MedGen:C3494506,OMIM:103580,Orphanet:79443|MONDO:MONDO:0012911,MedGen:C2932716,OMIM:612462,Orphanet:79444|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.