A: The variant NC_000020.11:g.4699813T>C in gene PRNP is classified as 'Pathogenic' for not_provided|Huntington_disease-like_1|Gerstmann-Straussler-Scheinker_syndrome. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0011299,MedGen:C1864112,OMIM:603218,Orphanet:157941|MONDO:MONDO:0007656,MedGen:C0017495,OMIM:137440,Orphanet:356. Review status: criteria provided, multiple submitters, no conflicts.