A: The variant NC_000023.11:g.12886451A>C in gene TLR7 is classified as 'Uncertain_significance' for not_provided|Systemic_lupus_erythematosus_17|Immunodeficiency_74,_COVID-19-related,_X-linked. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0859083,MedGen:C5676884,OMIM:301080|MONDO:MONDO:0026767,MedGen:C5435745,OMIM:301051. Review status: criteria provided, multiple submitters, no conflicts.