A: The variant NC_000021.9:g.45491249G>A in gene COL18A1 is classified as 'Uncertain_significance' for Hereditary_glaucoma,_primary_closed-angle|Knobloch_syndrome_1|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030038,MedGen:C5394374,OMIM:618880|MONDO:MONDO:0800167,MedGen:C4551775,OMIM:267750|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.