A: The variant NC_000019.10:g.49861891del in gene PNKP is classified as 'Benign/Likely_benign' for not_specified|Developmental_and_epileptic_encephalopathy,_12|Epileptic_encephalopathy|not_provided|Microcephaly,_seizures,_and_developmental_delay. Molecular consequence: SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MedGen:CN169374|MONDO:MONDO:0013389,MedGen:C3150988,OMIM:613722|Human_Phenotype_Ontology:HP:0200134,MedGen:C0543888|MedGen:C3661900|MONDO:MONDO:0013254,MedGen:C3150667,OMIM:613402,Orphanet:1934. Review status: criteria provided, multiple submitters, no conflicts.