A: The variant NC_000019.10:g.49158290A>G in gene TRPM4 is classified as 'Benign' for Progressive_familial_heart_block_type_IB|Erythrokeratodermia_variabilis_et_progressiva_6|not_provided. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011474,MedGen:C1970298,OMIM:604559,Orphanet:871|MONDO:MONDO:0032801,MedGen:C5193144,OMIM:618531|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.