A: The variant NC_000020.11:g.45421421G>A in gene PIGT is classified as 'Uncertain_significance' for Paroxysmal_nocturnal_hemoglobinuria_2. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014166,MedGen:C3809369,OMIM:615399,Orphanet:447. Review status: no assertion criteria provided.