A: The variant NC_000021.9:g.42388980G>A in gene TMPRSS3 is classified as 'Pathogenic' for Hearing_loss,_autosomal_recessive|not_provided. Molecular consequence: SO:0001587: nonsense,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.