A: The variant NC_000023.11:g.8585296del in gene ANOS1 is classified as 'Pathogenic' for Hypogonadotropic_hypogonadism_1_with_or_without_anosmia. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0010635,MedGen:C1563719,OMIM:308700,Orphanet:478. Review status: no assertion criteria provided.