A: The variant NC_000020.11:g.46128956A>G in gene CD40 is classified as 'Conflicting_classifications_of_pathogenicity' for Hyper-IgM_syndrome_type_3|not_provided. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001624: 3_prime_UTR_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090|MedGen:C3661900. Review status: criteria provided, conflicting classifications.