A: The variant NC_000022.11:g.50626250C>T in gene ARSA is classified as 'Pathogenic/Likely_pathogenic' for Neurologic,_endocrine,_and_pancreatic_disease,_multisystem,_infantile-onset_2|not_provided|Metachromatic_leukodystrophy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030375,MedGen:C5543623,OMIM:619418|MedGen:C3661900|MONDO:MONDO:0018868,MedGen:C0023522,OMIM:250100,Orphanet:512. Review status: criteria provided, multiple submitters, no conflicts.