A: The variant NC_000023.11:g.12920755G>T in gene TLR8 is classified as 'Pathogenic' for Immunodeficiency_98_with_autoinflammation,_X-linked|Autoimmune_hemolytic_anemia|Systemic_autoinflammation. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0024777,MedGen:C5676883,OMIM:301078,Orphanet:675628|Human_Phenotype_Ontology:HP:0001890,MONDO:MONDO:0020108,MedGen:C0002880,OMIM:205700,Orphanet:98375|Human_Phenotype_Ontology:HP:0033428,MedGen:C4015070. Review status: criteria provided, single submitter.