A: The variant NC_000020.11:g.35437858G>C in gene GDF5 is classified as 'Uncertain_significance' for Brachydactyly_type_C|Acromesomelic_dysplasia_2C,_Hunter-Thompson_type|Acromesomelic_dysplasia_2B|Type_A2_brachydactyly|Grebe_syndrome|Multiple_synostoses_syndrome_2|Brachydactyly_type_A1C|Symphalangism,_proximal,_1B. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0009373,MONDO:MONDO:0007221,MedGen:C1862103,OMIM:113100,Orphanet:93384|MONDO:MONDO:0008717,MedGen:C2930970,OMIM:201250,Orphanet:968|MONDO:MONDO:0009231,MedGen:C1856738,OMIM:228900,Orphanet:2639|Human_Phenotype_Ontology:HP:0009372,MONDO:MONDO:0007216,MedGen:C1832702,OMIM:112600,Orphanet:93396|MONDO:MONDO:0008703,MedGen:C0265260,OMIM:200700,Orphanet:2098|MONDO:MONDO:0012394,MedGen:C1832708,OMIM:610017,Orphanet:3237|MONDO:MONDO:0014032,MedGen:C3554446,OMIM:615072,Orphanet:93388|MONDO:MONDO:0014125,MedGen:C3809104,OMIM:615298,Orphanet:3250. Review status: criteria provided, single submitter.