A: The variant NC_000019.10:g.45354759C>T in gene ERCC2 is classified as 'Likely_pathogenic' for Trichothiodystrophy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018053,MedGen:C1955934,OMIM:PS601675,Orphanet:33364. Review status: criteria provided, single submitter.