A: The variant NC_000022.11:g.28725242C>T in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Melanoma|Breast_and_colorectal_cancer,_susceptibility_to|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast|Bone_osteosarcoma|Prostate_cancer|Colorectal_cancer|Familial_prostate_cancer|CHEK2-related_disorder|Inherited_breast_cancer_and_ovarian_cancer|Breast_cancer,_susceptibility_to|Breast_carcinoma|Breast_and/or_ovarian_cancer|Hereditary_cancer-predisposing_syndrome|Malignant_tumor_of_breast|TUMOR_PREDISPOSITION_SYNDROME_4,_BREAST/PROSTATE|Breast-ovarian_cancer,_familial,_susceptibility_to,_1|not_provided|Endometrial_carcinoma. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002861,Human_Phenotype_Ontology:HP:0002887,Human_Phenotype_Ontology:HP:0006777,Human_Phenotype_Ontology:HP:0007474,MONDO:MONDO:0005105,MeSH:D008545,MedGen:C0025202|MedGen:CN068920|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|.|.|MedGen:C3469522|Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222|MedGen:CN221562|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0007254,MedGen:C0006142|.|MONDO:MONDO:0011450,MedGen:C2676676,OMIM:604370,Orphanet:145|MedGen:C3661900|Human_Phenotype_Ontology:HP:0012114,MONDO:MONDO:0002447,MedGen:C0476089,OMIM:608089. Review status: criteria provided, multiple submitters, no conflicts.