A: The variant NC_000020.11:g.35433991C>T in gene GDF5 is classified as 'Pathogenic' for Multiple_synostoses_syndrome_2. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0012394,MedGen:C1832708,OMIM:610017,Orphanet:3237. Review status: no assertion criteria provided.