A: The variant NC_000023.11:g.12921538T>C in gene TLR8 is classified as 'Uncertain_significance' for Autoimmune_hemolytic_anemia|Systemic_autoinflammation. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0001890,MONDO:MONDO:0020108,MedGen:C0002880,OMIM:205700,Orphanet:98375|Human_Phenotype_Ontology:HP:0033428,MedGen:C4015070. Review status: criteria provided, single submitter.