A: The variant NC_000020.11:g.35434143G>C in gene GDF5 is classified as 'Uncertain_significance' for Acromesomelic_dysplasia_2C,_Hunter-Thompson_type. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008717,MedGen:C2930970,OMIM:201250,Orphanet:968. Review status: criteria provided, single submitter.