A: The variant NC_000019.10:g.50406397A>C in gene POLD1 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome|Mandibular_hypoplasia-deafness-progeroid_syndrome. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0014157,MedGen:C3715192,OMIM:615381,Orphanet:363649. Review status: criteria provided, multiple submitters, no conflicts.