A: The variant NC_000021.9:g.25975239A>C in gene APP is classified as 'Uncertain_significance' for Alzheimer_disease_type_1. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300. Review status: criteria provided, single submitter.