A: The variant NC_000019.10:g.17843895G>A in gene JAK3 is classified as 'Uncertain_significance' for Severe_combined_immunodeficiency_disease. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0004430,MONDO:MONDO:0015974,MeSH:D016511,MedGen:C0085110,Orphanet:183660. Review status: criteria provided, single submitter.