A: The variant NC_000019.10:g.50401769_50401794del in gene POLD1 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, single submitter.