A: The variant NC_000021.9:g.46222635C>T in gene LSS is classified as 'Pathogenic' for Alopecia-intellectual_disability_syndrome_4. Molecular consequence: SO:0001587: nonsense,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030009,MedGen:C5394241,OMIM:618840. Review status: no assertion criteria provided.