A: The variant NC_000022.11:g.28710008G>C in gene CHEK2 is classified as 'Uncertain_significance' for Bone_osteosarcoma|CHEK2-related_cancer_predisposition|Familial_prostate_cancer. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331. Review status: criteria provided, single submitter.