A: The variant NC_000022.11:g.28734452del in gene CHEK2 is classified as 'Likely_pathogenic' for Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, single submitter.