A: The variant NC_000019.10:g.50402267C>T in gene POLD1 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome|Colorectal_cancer,_susceptibility_to,_10|Mandibular_hypoplasia-deafness-progeroid_syndrome|Immunodeficiency_120. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460|MONDO:MONDO:0014157,MedGen:C3715192,OMIM:615381,Orphanet:363649|MONDO:MONDO:0970994,MedGen:C5935622,OMIM:620836. Review status: criteria provided, multiple submitters, no conflicts.