A: The variant NC_000022.11:g.28734439G>A in gene CHEK2 is classified as 'Pathogenic' for not_provided|CHEK2-related_cancer_predisposition|CHEK2-related_disorder|Gastric_cancer|Malignant_tumor_of_breast|Hereditary_cancer-predisposing_syndrome|Bone_osteosarcoma|Familial_cancer_of_breast|Prostate_cancer|Colorectal_cancer|not_specified|Hereditary_breast_ovarian_cancer_syndrome|Li-Fraumeni_syndrome. Molecular consequence: SO:0001587: nonsense,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|.|Human_Phenotype_Ontology:HP:0012126,MONDO:MONDO:0001056,MeSH:D013274,MedGen:C0024623,OMIM:613659|MONDO:MONDO:0007254,MedGen:C0006142|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MedGen:CN169374|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0018875,MedGen:C0085390,OMIM:PS151623,Orphanet:524. Review status: criteria provided, multiple submitters, no conflicts.