A: The variant NC_000019.10:g.38469119C>T in gene RYR1 is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|RYR1-related_disorder|Malignant_hyperthermia,_susceptibility_to,_1|not_specified|Scoliosis|Pelvic_girdle_muscle_weakness|Proximal_muscle_weakness|Progressive_distal_muscle_weakness|Delayed_gross_motor_development. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN239331|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MedGen:CN169374|Human_Phenotype_Ontology:HP:0002650,Human_Phenotype_Ontology:HP:0002770,Human_Phenotype_Ontology:HP:0003303,Human_Phenotype_Ontology:HP:0003317,Human_Phenotype_Ontology:HP:0003415,MONDO:MONDO:0005392,MedGen:C0036439|Human_Phenotype_Ontology:HP:0003692,Human_Phenotype_Ontology:HP:0003749,Human_Phenotype_Ontology:HP:0008999,Human_Phenotype_Ontology:HP:0009036,MedGen:C0427064|Human_Phenotype_Ontology:HP:0003432,Human_Phenotype_Ontology:HP:0003475,Human_Phenotype_Ontology:HP:0003701,Human_Phenotype_Ontology:HP:0007195,Human_Phenotype_Ontology:HP:0008950,Human_Phenotype_Ontology:HP:0008961,Human_Phenotype_Ontology:HP:0008975,Human_Phenotype_Ontology:HP:0009033,Human_Phenotype_Ontology:HP:0009075,MedGen:C0221629|Human_Phenotype_Ontology:HP:0008933,Human_Phenotype_Ontology:HP:0009022,Human_Phenotype_Ontology:HP:0009057,Human_Phenotype_Ontology:HP:0009063,MedGen:C1836609|Human_Phenotype_Ontology:HP:0002194,Human_Phenotype_Ontology:HP:0006905,Human_Phenotype_Ontology:HP:0007046,Human_Phenotype_Ontology:HP:0008973,MedGen:C1837658. Review status: criteria provided, conflicting classifications.