A: The variant NC_000021.9:g.36756723_36756725del in gene HLCS is classified as 'Uncertain_significance' for Holocarboxylase_synthetase_deficiency|not_specified. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001822: inframe_deletion. Variant type: Deletion. Disease database links: MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.