A: The variant NC_000022.11:g.50625392G>A in gene ARSA is classified as 'Pathogenic' for Intellectual_disability|See_cases|ARSA-related_disorder|not_provided|Metachromatic_leukodystrophy|Metachromatic_leukodystrophy,_juvenile_type|Metachromatic_leukodystrophy,_adult_type|.. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000730,Human_Phenotype_Ontology:HP:0001249,Human_Phenotype_Ontology:HP:0001267,Human_Phenotype_Ontology:HP:0001286,Human_Phenotype_Ontology:HP:0002122,Human_Phenotype_Ontology:HP:0002192,Human_Phenotype_Ontology:HP:0002316,Human_Phenotype_Ontology:HP:0002382,Human_Phenotype_Ontology:HP:0002386,Human_Phenotype_Ontology:HP:0002402,Human_Phenotype_Ontology:HP:0002458,Human_Phenotype_Ontology:HP:0002482,Human_Phenotype_Ontology:HP:0002499,Human_Phenotype_Ontology:HP:0002543,Human_Phenotype_Ontology:HP:0003767,Human_Phenotype_Ontology:HP:0006833,Human_Phenotype_Ontology:HP:0007154,Human_Phenotype_Ontology:HP:0007176,Human_Phenotype_Ontology:HP:0007180,MONDO:MONDO:0001071,MeSH:D008607,MedGen:C3714756|.|.|MedGen:C3661900|MONDO:MONDO:0018868,MedGen:C0023522,OMIM:250100,Orphanet:512|MONDO:MONDO:0009591,MedGen:C0751276,Orphanet:309263|MONDO:MONDO:0017730,MedGen:C0751279,Orphanet:309271|.. Review status: criteria provided, multiple submitters, no conflicts.