A: The variant NC_000019.10:g.45494982G>A in gene RTN2 is classified as 'Pathogenic' for Hereditary_spastic_paraplegia_12. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993. Review status: no assertion criteria provided.