A: The variant NC_000021.9:g.43065480C>T in gene CBS is classified as 'Benign/Likely_benign' for Connective_tissue_disorder|not_provided|not_specified|Familial_thoracic_aortic_aneurysm_and_aortic_dissection|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED|Classic_homocystinuria. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0003900,MedGen:C0009782|MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387|MedGen:C3150344|MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394. Review status: criteria provided, multiple submitters, no conflicts.