A: The variant NC_000020.11:g.34413798dup in gene ITCH is classified as 'Pathogenic' for not_provided|Syndromic_multisystem_autoimmune_disease_due_to_ITCH_deficiency. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MedGen:C3661900|MONDO:MONDO:0013245,MedGen:C3150649,OMIM:613385,Orphanet:228426. Review status: criteria provided, multiple submitters, no conflicts.