A: The variant NC_000023.11:g.8623669C>T in gene ANOS1 is classified as 'Uncertain_significance' for Hypogonadotropic_hypogonadism. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000044,Human_Phenotype_Ontology:HP:0003335,Human_Phenotype_Ontology:HP:0008224,MONDO:MONDO:0018555,MedGen:C0271623,OMIM:PS147950,Orphanet:432. Review status: criteria provided, single submitter.