A: The variant NC_000019.10:g.41342025T>G in gene TGFB1 is classified as 'Uncertain_significance' for TGFB1-related_disorder|Cystic_fibrosis|Inflammatory_bowel_disease,_immunodeficiency,_and_encephalopathy|Diaphyseal_dysplasia|Inborn_genetic_diseases|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0009061,MedGen:C0010674,OMIM:219700,Orphanet:586|MONDO:MONDO:0032601,MedGen:C4748708,OMIM:618213,Orphanet:565788|Human_Phenotype_Ontology:HP:0100252,MONDO:MONDO:0007542,MedGen:C0011989,OMIM:131300,Orphanet:1328|MeSH:D030342,MedGen:C0950123|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.