A: The variant NC_000019.10:g.49210718C>G in gene TRPM4 is classified as 'Uncertain_significance' for Long_QT_syndrome|Progressive_familial_heart_block_type_IB|Conduction_system_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0002442,MeSH:D008133,MedGen:C0023976|MONDO:MONDO:0011474,MedGen:C1970298,OMIM:604559,Orphanet:871|EFO:EFO_0005137,MONDO:MONDO:0005449,MedGen:C2748542. Review status: criteria provided, multiple submitters, no conflicts.