A: The variant NC_000022.11:g.28725099A>G in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity|risk_factor' for Bone_osteosarcoma|Familial_prostate_cancer|Familial_cancer_of_breast|Colorectal_cancer|CHEK2-related_cancer_predisposition|Adrenal_cortex_carcinoma|Gastrointestinal_carcinoma|TUMOR_PREDISPOSITION_SYNDROME_4,_BREAST/PROSTATE/COLORECTAL|CHEK2-related_disorder|Malignant_tumor_of_breast|not_specified|Breast_and_colorectal_cancer,_susceptibility_to|not_provided|Hereditary_cancer-predisposing_syndrome|Predisposition_to_cancer|Prostate_cancer|Breast_and/or_ovarian_cancer. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|Human_Phenotype_Ontology:HP:0002889,Human_Phenotype_Ontology:HP:0006744,Human_Phenotype_Ontology:HP:0006759,MONDO:MONDO:0006639,MeSH:D018268,MedGen:C0206686,Orphanet:1501|Human_Phenotype_Ontology:HP:0002672,MONDO:MONDO:0006181,MedGen:C0151544|.|.|MONDO:MONDO:0007254,MedGen:C0006142|MedGen:CN169374|MedGen:CN068920|MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|.|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MedGen:CN221562. Review status: criteria provided, conflicting classifications.