A: The variant NC_000022.11:g.42627690T>G in gene CYB5R3 is classified as 'Pathogenic/Likely_pathogenic' for Deficiency_of_cytochrome-b5_reductase|not_provided|METHEMOGLOBINEMIA,_TYPE_II. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009606,MedGen:C0268193,OMIM:250800,Orphanet:621|MedGen:C3661900|MedGen:C2749560. Review status: criteria provided, multiple submitters, no conflicts.