A: The variant NC_000019.10:g.42248564del in gene ERF is classified as 'Uncertain_significance' for Noonan_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0018997,MeSH:D009634,MedGen:C0028326,OMIM:PS163950,Orphanet:648. Review status: no assertion criteria provided.