A: The variant NC_000019.10:g.18606648_18606654del in gene CRLF1 is classified as 'Likely_pathogenic' for Cold-induced_sweating_syndrome. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0015526,MedGen:C1832409,OMIM:PS272430,Orphanet:157820. Review status: criteria provided, single submitter.