A: The variant NC_000019.10:g.50417928del in gene POLD1 is classified as 'Uncertain_significance' for not_provided|POLD1-related_disorder|not_specified|Hereditary_cancer-predisposing_syndrome|Colorectal_cancer,_susceptibility_to,_10. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MedGen:C3661900|.|MedGen:CN169374|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460. Review status: criteria provided, multiple submitters, no conflicts. Oncogenicity: ONC: Uncertain_significance, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005094017