A: The variant NC_000020.11:g.4699400T>C in gene PRNP is classified as 'Uncertain_significance' for Spongiform_encephalopathy_with_neuropsychiatric_features. Molecular consequence: SO:0001583: missense_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011703,MedGen:C1847650,OMIM:606688. Review status: criteria provided, single submitter.