A: The variant NC_000019.10:g.50403490C>T in gene POLD1 is classified as 'Likely_benign' for not_provided|not_specified|Hereditary_cancer-predisposing_syndrome|Carcinoma_of_colon|Colorectal_cancer,_susceptibility_to,_10. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0002032,MedGen:C0699790|MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460. Review status: criteria provided, multiple submitters, no conflicts.