A: The variant NC_000022.11:g.30612965_30612966insAC in gene TCN2 is classified as 'Pathogenic/Likely_pathogenic' for Transcobalamin_II_deficiency. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Insertion. Disease database links: MONDO:MONDO:0010149,MedGen:C0342701,OMIM:275350,Orphanet:859. Review status: criteria provided, multiple submitters, no conflicts.