A: The variant NC_000019.10:g.18788580G>T in gene COMP is classified as 'Benign/Likely_benign' for Multiple_epiphyseal_dysplasia_type_1|Pseudoachondroplastic_spondyloepiphyseal_dysplasia_syndrome|not_specified|not_provided. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007561,MedGen:C1838280,OMIM:132400,Orphanet:93308|MONDO:MONDO:0008322,MedGen:C0410538,OMIM:177170,Orphanet:750|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.