A: The variant NC_000019.10:g.19197007C>T in gene RFXANK is classified as 'Pathogenic/Likely_pathogenic' for MHC_class_II_deficiency_2|MHC_class_II_deficiency. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0971013,MedGen:C1859535,OMIM:620815|MONDO:MONDO:0008855,MedGen:C5447452,OMIM:PS209920,Orphanet:572. Review status: criteria provided, multiple submitters, no conflicts.