A: The variant NC_000020.11:g.46118343T>C in gene CD40 is classified as 'Benign' for not_specified|Hyper-IgM_syndrome_type_3|not_provided. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.