A: The variant NC_000020.11:g.6031359C>T in gene CRLS1 is classified as 'Pathogenic' for Combined_oxidative_phosphorylation_deficiency_57. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0859337,MedGen:C5774275,OMIM:620167. Review status: no assertion criteria provided.