A: The variant NC_000019.10:g.29702967_29702977del in gene C19orf12 is classified as 'Pathogenic/Likely_pathogenic' for C19orf12-related_disorder|Neurodegeneration_with_brain_iron_accumulation|not_provided|Hereditary_spastic_paraplegia_43|Neurodegeneration_with_brain_iron_accumulation_4. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Deletion. Disease database links: .|MONDO:MONDO:0018307,MedGen:C2931845,OMIM:PS234200,Orphanet:385|MedGen:C3661900|MONDO:MONDO:0014024,MedGen:C2680446,OMIM:615043,Orphanet:320370|MONDO:MONDO:0013674,MedGen:C3280371,OMIM:614298,Orphanet:289560. Review status: criteria provided, multiple submitters, no conflicts.