A: The variant NC_000019.10:g.49662076C>T in gene IRF3 is classified as 'Uncertain_significance|risk_factor' for IRF3-related_disorder|Encephalopathy,_acute,_infection-induced_(herpes-specific),_susceptibility_to,_7. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0014680,MedGen:C4225294,OMIM:616532,Orphanet:1930. Review status: no assertion criteria provided.