A: The variant NC_000019.10:g.35643388del in gene ETV2 is classified as 'Likely_pathogenic' for Hypoplastic_left_heart_syndrome|Polydactyly|Heart,_malformation_of|Abnormal_vertebral_morphology. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0004383,MONDO:MONDO:0004933,MedGen:C0152101,OMIM:PS241550,Orphanet:2248|Human_Phenotype_Ontology:HP:0006034,Human_Phenotype_Ontology:HP:0006046,Human_Phenotype_Ontology:HP:0006123,Human_Phenotype_Ontology:HP:0009605,Human_Phenotype_Ontology:HP:0010442,MONDO:MONDO:0021003,MedGen:C0152427,OMIM:603596|MONDO:MONDO:0009327,MeSH:D006330,MedGen:C0018798,OMIM:140500,OMIM:234750|Human_Phenotype_Ontology:HP:0003468,Human_Phenotype_Ontology:HP:0005719,MedGen:C1834129. Review status: no assertion criteria provided.