A: The variant NC_000022.11:g.41526394G>A in gene ACO2 is classified as 'Uncertain_significance' for not_provided|OPTIC_ATROPHY_9,_AUTOSOMAL_RECESSIVE. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|.. Review status: criteria provided, single submitter.