A: The variant NC_000022.11:g.46353766G>C in gene TRMU is classified as 'Likely_pathogenic' for Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013111,MedGen:C3278664,OMIM:613070,Orphanet:217371. Review status: criteria provided, single submitter.