A: The variant NC_000020.11:g.5972581del in gene MCM8 is classified as 'Uncertain_significance' for Premature_ovarian_failure_10. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0044776,MedGen:C4225402,OMIM:612885. Review status: criteria provided, single submitter.