A: The variant NC_000022.11:g.19524080_19524082dup in gene CLDN5 is classified as 'Likely_pathogenic' for CLDN5-related_neurodevelopmental_disorder. Molecular consequence: SO:0001820: inframe_indel,SO:0001821: inframe_insertion. Variant type: Duplication. Disease database links: .. Review status: criteria provided, single submitter.