A: The variant NC_000021.9:g.44509225del in gene TSPEAR is classified as 'Pathogenic' for Autosomal_recessive_nonsyndromic_hearing_loss_98|Tooth_agenesis,_selective,_10|Ectodermal_dysplasia_14,_hair/tooth_type,_with_hypohidrosis. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0013929,MedGen:C3553932,OMIM:614861,Orphanet:90636|MONDO:MONDO:0859339,MedGen:C5774277,OMIM:620173|.. Review status: criteria provided, single submitter.