A: The variant NC_000022.11:g.25231617C>T in gene CRYBB2 is classified as 'Pathogenic' for Developmental_cataract|not_provided|CRYBB2-related_disorder|Cataract_3_multiple_types. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000519,Human_Phenotype_Ontology:HP:0001108,Human_Phenotype_Ontology:HP:0007679,Human_Phenotype_Ontology:HP:0007726,Human_Phenotype_Ontology:HP:0007788,MedGen:C0009691|MedGen:C3661900|.|MONDO:MONDO:0011104,MedGen:C1832175,OMIM:601547,Orphanet:1377. Review status: criteria provided, multiple submitters, no conflicts.