A: The variant NC_000022.11:g.50626709G>A in gene ARSA is classified as 'Pathogenic/Likely_pathogenic' for Metachromatic_leukodystrophy|Metachromatic_leukodystrophy,_juvenile_type. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018868,MedGen:C0023522,OMIM:250100,Orphanet:512|MONDO:MONDO:0009591,MedGen:C0751276,Orphanet:309263. Review status: criteria provided, multiple submitters, no conflicts.