A: The variant NC_000019.10:g.41894637C>T in gene ARHGEF1 is classified as 'Pathogenic' for Immunodeficiency_62. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032763,MedGen:C5193109,OMIM:618459. Review status: no assertion criteria provided.