A: The variant NC_000019.10:g.15185592C>T in gene NOTCH3 is classified as 'Benign/Likely_benign' for not_provided|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|Pulmonary_arterial_hypertension|Myofibromatosis,_infantile,_2|Lateral_meningocele_syndrome|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|Human_Phenotype_Ontology:HP:0002092,Human_Phenotype_Ontology:HP:0006546,MONDO:MONDO:0015924,MeSH:D000081029,MedGen:C2973725,Orphanet:182090|MONDO:MONDO:0014122,MedGen:C3809084,OMIM:615293,Orphanet:2591|MONDO:MONDO:0007537,MedGen:C1851710,OMIM:130720,Orphanet:2789|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.