A: The variant NC_000020.11:g.46725452A>G in gene SLC2A10 is classified as 'Uncertain_significance' for Arterial_tortuosity_syndrome|not_provided|Familial_thoracic_aortic_aneurysm_and_aortic_dissection. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008818,MedGen:C1859726,OMIM:208050,Orphanet:3342|MedGen:C3661900|MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387. Review status: criteria provided, multiple submitters, no conflicts.