A: The variant NC_000020.11:g.46122360T>C in gene CD40 is classified as 'Conflicting_classifications_of_pathogenicity' for not_specified|Hyper-IgM_syndrome_type_3|Hyper-IgM_syndrome_type_1. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090|MONDO:MONDO:0010626,MedGen:C0398689,OMIM:308230,Orphanet:101088. Review status: criteria provided, conflicting classifications.