A: The variant NC_000019.10:g.15254175G>A in gene BRD4 is classified as 'Uncertain_significance' for De_Lange_syndrome. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016033,MedGen:C0270972,OMIM:PS122470,Orphanet:199. Review status: criteria provided, single submitter.