A: The variant NC_000021.9:g.44521945del in gene TSPEAR is classified as 'Pathogenic' for Tooth_agenesis,_selective,_10. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0859339,MedGen:C5774277,OMIM:620173. Review status: no assertion criteria provided.