A: The variant NC_000020.11:g.36935048G>A in gene SAMHD1 is classified as 'Pathogenic/Likely_pathogenic' for Aicardi_Goutieres_syndrome|Chilblain_lupus_2|Aicardi-Goutieres_syndrome_5. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018866,MedGen:C0393591,OMIM:PS225750,Orphanet:51|MONDO:MONDO:0013739,MedGen:C3280721,OMIM:614415|MONDO:MONDO:0013059,MedGen:C2749659,OMIM:612952,Orphanet:51. Review status: criteria provided, multiple submitters, no conflicts.