A: The variant NC_000019.10:g.43511460C>T in gene ETHE1 is classified as 'Likely_pathogenic' for Ethylmalonic_encephalopathy|Abnormality_of_the_nervous_system. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011229,MedGen:C1865349,OMIM:602473,Orphanet:51188|Human_Phenotype_Ontology:HP:0000707,Human_Phenotype_Ontology:HP:0001333,Human_Phenotype_Ontology:HP:0006987,MONDO:MONDO:0002320,MedGen:C0497552. Review status: criteria provided, multiple submitters, no conflicts.