A: The variant NC_000023.11:g.15321680_15321681del in gene PIGA is classified as 'Likely_pathogenic' for Paroxysmal_nocturnal_hemoglobinuria_1. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0010438,MedGen:C3806670,OMIM:300818,Orphanet:447. Review status: criteria provided, single submitter.