A: The variant NC_000019.10:g.38442373T>C in gene RYR1 is classified as 'Uncertain_significance' for Malignant_hyperthermia_of_anesthesia|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|MedGen:C3661900. Review status: reviewed by expert panel.