A: The variant NC_000021.9:g.34792318_34792324dup in gene RUNX1 is classified as 'Likely_pathogenic' for Atypical_chronic_myeloid_leukemia,_BCR-ABL1_negative|Hereditary_thrombocytopenia_and_hematologic_cancer_predisposition_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0004653,MedGen:C1292772,Orphanet:98824|MONDO:MONDO:0011071,MedGen:CN281654,Orphanet:71290. Review status: reviewed by expert panel.