A: The variant NC_000019.10:g.50413828G>A in gene POLD1 is classified as 'Benign/Likely_benign' for Colorectal_cancer,_susceptibility_to,_10|Hereditary_cancer-predisposing_syndrome|not_specified|not_provided|Immunodeficiency_120|Mandibular_hypoplasia-deafness-progeroid_syndrome. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0012953,MedGen:C2675481,OMIM:612591,Orphanet:220460|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374|MedGen:C3661900|MONDO:MONDO:0970994,MedGen:C5935622,OMIM:620836|MONDO:MONDO:0014157,MedGen:C3715192,OMIM:615381,Orphanet:363649. Review status: criteria provided, multiple submitters, no conflicts.