A: The variant NC_000021.9:g.45537880T>C in gene SLC19A1 is classified as 'drug_response' for Lung_cancer|Gastrointestinal_stromal_tumor|methotrexate_response_-_Efficacy|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008903,MedGen:C0242379,OMIM:211980|Human_Phenotype_Ontology:HP:0100723,MONDO:MONDO:0011719,MeSH:D046152,MedGen:C0238198,OMIM:606764,Orphanet:44890|MedGen:CN322736|MedGen:C3661900. Review status: reviewed by expert panel.