A: The variant NC_000020.11:g.8722354_8722356del in gene PLCB1 is classified as 'Uncertain_significance' for Developmental_and_epileptic_encephalopathy,_12. Variant type: Deletion. Disease database links: MONDO:MONDO:0013389,MedGen:C3150988,OMIM:613722. Review status: criteria provided, single submitter.