A: The variant NC_000021.9:g.43053933_43053934del in gene CBS is classified as 'Likely_pathogenic' for Classic_homocystinuria. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394. Review status: criteria provided, single submitter.