A: The variant NC_000021.9:g.44533869C>T in gene TSPEAR is classified as 'Uncertain_significance' for not_provided|Inborn_genetic_diseases|Autosomal_recessive_nonsyndromic_hearing_loss_98|Ectodermal_dysplasia_14,_hair/tooth_type_with_or_without_hypohidrosis. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0013929,MedGen:C3553932,OMIM:614861,Orphanet:90636|MONDO:MONDO:0032584,MedGen:C4748560,OMIM:618180. Review status: criteria provided, multiple submitters, no conflicts.