A: The variant NC_000022.11:g.28725064del in gene CHEK2 is classified as 'Pathogenic' for Familial_cancer_of_breast|Hereditary_cancer-predisposing_syndrome|Colorectal_cancer|not_provided|CHEK2-related_cancer_predisposition|Familial_prostate_cancer. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MedGen:C3661900|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331. Review status: criteria provided, multiple submitters, no conflicts.