A: The variant NC_000022.11:g.50721470dup in gene SHANK3 is classified as 'Pathogenic' for Moderate_global_developmental_delay|Psychotic_disorder|Mutism|Phelan-McDermid_syndrome|Schizophrenia_15. Variant type: Duplication. Disease database links: Human_Phenotype_Ontology:HP:0011343,MedGen:C2237142|Human_Phenotype_Ontology:HP:0000709,MONDO:MONDO:0005485,MedGen:C0033975|Human_Phenotype_Ontology:HP:0002300,MONDO:MONDO:0002905,MedGen:C0026884|MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MONDO:MONDO:0013498,MedGen:C3151380,OMIM:613950. Review status: criteria provided, multiple submitters, no conflicts.