A: The variant NC_000022.11:g.28687974G>A in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Breast_and_colorectal_cancer,_susceptibility_to|not_provided|CHEK2-related_cancer_predisposition|Hereditary_cancer-predisposing_syndrome|Gastric_cancer|Breast_and/or_ovarian_cancer|Familial_cancer_of_breast|Familial_prostate_cancer|Hereditary_breast_ovarian_cancer_syndrome|Bone_osteosarcoma. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN068920|MedGen:C3661900|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|Human_Phenotype_Ontology:HP:0012126,MONDO:MONDO:0001056,MeSH:D013274,MedGen:C0024623,OMIM:613659|MedGen:CN221562|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668. Review status: criteria provided, multiple submitters, no conflicts.