A: The variant NC_000019.10:g.15191635C>T in gene NOTCH3 is classified as 'Benign/Likely_benign' for Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|not_provided|Lateral_meningocele_syndrome|Myofibromatosis,_infantile,_2. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|MedGen:C3661900|MONDO:MONDO:0007537,MedGen:C1851710,OMIM:130720,Orphanet:2789|MONDO:MONDO:0014122,MedGen:C3809084,OMIM:615293,Orphanet:2591. Review status: criteria provided, multiple submitters, no conflicts.