A: The variant NC_000022.11:g.28725012T>C in gene CHEK2 is classified as 'Uncertain_significance' for CHEK2-related_cancer_predisposition|not_provided|Hereditary_cancer-predisposing_syndrome|Malignant_tumor_of_breast|Familial_cancer_of_breast|not_specified|Familial_prostate_cancer|Bone_osteosarcoma. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0007254,MedGen:C0006142|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:CN169374|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668. Review status: criteria provided, multiple submitters, no conflicts.