A: The variant NC_000023.11:g.8535674C>A in gene ANOS1 is classified as 'Benign/Likely_benign' for not_provided|Amenorrhea|Hypogonadotropic_hypogonadism_1_with_or_without_anosmia|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0000141,MONDO:MONDO:0001836,MedGen:C0002453|MONDO:MONDO:0010635,MedGen:C1563719,OMIM:308700,Orphanet:478|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.