A: The variant NC_000020.11:g.5986027C>T in gene MCM8 is classified as 'Pathogenic' for Premature_ovarian_failure_10. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0044776,MedGen:C4225402,OMIM:612885. Review status: no assertion criteria provided.