A: The variant NC_000022.11:g.20995995C>T in gene LZTR1 is classified as 'Uncertain_significance' for Noonan_syndrome_2. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648. Review status: criteria provided, single submitter.