A: The variant NC_000020.11:g.35434514G>A in gene GDF5 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Brachydactyly_type_C|Multiple_synostoses_syndrome_2. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|Human_Phenotype_Ontology:HP:0009373,MONDO:MONDO:0007221,MedGen:C1862103,OMIM:113100,Orphanet:93384|MONDO:MONDO:0012394,MedGen:C1832708,OMIM:610017,Orphanet:3237. Review status: criteria provided, multiple submitters, no conflicts.