A: The variant NC_000019.10:g.42406374G>A in gene LIPE is classified as 'Likely_pathogenic' for LIPE-related_familial_partial_lipodystrophy. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014431,MedGen:C4014869,OMIM:615980,Orphanet:435660. Review status: criteria provided, multiple submitters, no conflicts.