A: The variant NC_000019.10:g.49861227T>G in gene PNKP is classified as 'Benign' for not_provided|Microcephaly,_seizures,_and_developmental_delay. Molecular consequence: SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0013254,MedGen:C3150667,OMIM:613402,Orphanet:1934. Review status: criteria provided, multiple submitters, no conflicts.