A: The variant NC_000022.11:g.41469182G>A in gene ACO2 is classified as 'Likely_pathogenic' for Optic_atrophy|Optic_atrophy_9. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000648,Human_Phenotype_Ontology:HP:0007751,Human_Phenotype_Ontology:HP:0007855,MONDO:MONDO:0003608,MedGen:C0029124|MONDO:MONDO:0014571,MedGen:C4225384,OMIM:616289. Review status: criteria provided, single submitter.