A: The variant NC_000020.11:g.10645251_10645261delinsCACGTGCAGGTGGTGTGT in gene JAG1 is classified as 'Likely_pathogenic' for Familial_thoracic_aortic_aneurysm_and_aortic_dissection. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: Indel. Disease database links: MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387. Review status: criteria provided, single submitter.