A: The variant NC_000021.9:g.42389044del in gene TMPRSS3 is classified as 'Pathogenic/Likely_pathogenic' for Inborn_genetic_diseases|Autosomal_recessive_nonsyndromic_hearing_loss_8|not_provided|TMPRSS3-related_disorder|Nonsyndromic_genetic_hearing_loss|Rare_genetic_deafness|Hearing_impairment. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant. Variant type: Deletion. Disease database links: MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636|MedGen:C3661900|.|MONDO:MONDO:0019497,MedGen:C5680182,Orphanet:87884|MedGen:C5680250,Orphanet:96210|Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666. Review status: criteria provided, multiple submitters, no conflicts.