A: The variant NC_000022.11:g.20992250del in gene LZTR1 is classified as 'Pathogenic' for not_provided|RASopathy|Noonan_syndrome_2. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MedGen:C3661900|MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648. Review status: reviewed by expert panel.