A: The variant NC_000022.11:g.50627221A>G in gene ARSA is classified as 'Pathogenic' for Metachromatic_leukodystrophy,_adult_type. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0017730,MedGen:C0751279,Orphanet:309271. Review status: no assertion criteria provided.