A: The variant NC_000022.11:g.50704971G>A in gene SHANK3 is classified as 'Likely_benign' for Intellectual_disability-hypotonia-spasticity-sleep_disorder_syndrome. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014210,MedGen:C3809672,OMIM:615493,Orphanet:356996. Review status: criteria provided, single submitter.