A: The variant NC_000023.11:g.11298125A>G in gene AMELX is classified as 'Uncertain_significance' for Amelogenesis_imperfecta_type_1E|Inborn_genetic_diseases. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010521,MedGen:C1845053,OMIM:301200,Orphanet:88661|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.