A: The variant NC_000023.11:g.12919368C>G in gene TLR8 is classified as 'Uncertain_significance' for Immunodeficiency_98_with_autoinflammation,_X-linked. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0024777,MedGen:C5676883,OMIM:301078,Orphanet:675628. Review status: criteria provided, single submitter.