A: The variant NC_000022.11:g.20994274G>A in gene LZTR1 is classified as 'Uncertain_significance' for not_specified|Diffuse_midline_glioma,_H3_K27-altered|Cardiovascular_phenotype|Hereditary_cancer-predisposing_syndrome|not_provided|Noonan_syndrome_2|Noonan_syndrome_10. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MedGen:C5669877|MedGen:CN230736|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648. Review status: criteria provided, multiple submitters, no conflicts.