A: The variant NC_000021.9:g.25911810T>C in gene APP is classified as 'Benign/Likely_benign' for Cerebral_amyloid_angiopathy,_APP-related|Alzheimer_disease_type_1|not_specified|Alzheimer_disease. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458|MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300|MedGen:CN169374|Human_Phenotype_Ontology:HP:0002511,Human_Phenotype_Ontology:HP:0006878,Human_Phenotype_Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020. Review status: criteria provided, multiple submitters, no conflicts.