A: The variant NC_000019.10:g.15197577G>C in gene NOTCH3 is classified as 'Benign/Likely_benign' for not_provided|Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy|not_specified. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.