A: The variant NC_000022.11:g.28725259T>C in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for Familial_cancer_of_breast|not_specified|Li-Fraumeni_syndrome|Familial_colorectal_cancer_type_X|CHEK2-related_disorder|Hereditary_cancer-predisposing_syndrome|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:CN169374|MONDO:MONDO:0018875,MedGen:C0085390,OMIM:PS151623,Orphanet:524|MONDO:MONDO:0018604,MedGen:C3896578,Orphanet:440437|.|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900. Review status: criteria provided, conflicting classifications.