A: The variant NC_000021.9:g.25598338C>T in gene MRPL39 is classified as 'Pathogenic' for Mitochondrial_disease|Leigh_syndrome|Combined_oxidative_phosphorylation_deficiency_59. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0044970,MeSH:D028361,MedGen:C0751651,Orphanet:68380|MONDO:MONDO:0009723,MedGen:C2931891,OMIM:256000,Orphanet:506|MONDO:MONDO:0957992,MedGen:C5882730,OMIM:620646. Review status: criteria provided, single submitter.