A: The variant NC_000019.10:g.38584989T>C in gene RYR1 is classified as 'Uncertain_significance|drug_response' for RYR1-related_myopathy|RYR1-related_disorder|Congenital_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|Congenital_myopathy_with_fiber_type_disproportion|Congenital_multicore_myopathy_with_external_ophthalmoplegia|Central_core_myopathy|not_provided|succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|halothane_response_-_Toxicity|enflurane_response_-_Toxicity|desflurane_response_-_Toxicity. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0100150,MedGen:CN305348|MedGen:CN239331|MONDO:MONDO:0019952,MedGen:C0270960,OMIM:PS117000,Orphanet:97245|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MedGen:C3661900|.|.|.|.|.|.|.. Review status: reviewed by expert panel.