A: The variant NC_000020.11:g.3218580_3218587dup in gene ITPA is classified as 'Pathogenic/Likely_pathogenic' for Hypodontia|Developmental_and_epileptic_encephalopathy,_35|not_provided|Inosine_triphosphatase_deficiency. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: Human_Phenotype_Ontology:HP:0000668,MONDO:MONDO:0005486,MedGen:C0020608,OMIM:PS106600,Orphanet:99798|MONDO:MONDO:0014719,MedGen:C4225256,OMIM:616647,Orphanet:457375|MedGen:C3661900|MONDO:MONDO:0013461,MedGen:C0342800,OMIM:613850. Review status: criteria provided, multiple submitters, no conflicts.