A: The variant NC_000019.10:g.45494887G>T in gene RTN2 is classified as 'Conflicting_classifications_of_pathogenicity' for Hereditary_spastic_paraplegia_12|not_provided. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993|MedGen:C3661900. Review status: criteria provided, conflicting classifications.