A: The variant NC_000021.9:g.43058178T>G in gene CBS is classified as 'Uncertain_significance' for Familial_thoracic_aortic_aneurysm_and_aortic_dissection. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387. Review status: criteria provided, single submitter.