A: The variant NC_000019.10:g.18160581dup in gene PIK3R2 is classified as 'Benign' for Megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome_1|not_specified. Molecular consequence: SO:0001627: intron_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0011313,MedGen:C4012727,OMIM:603387,Orphanet:83473|MedGen:CN169374. Review status: criteria provided, single submitter.