A: The variant NC_000019.10:g.45478610G>C in gene TRU-TCA1-1 is classified as 'Pathogenic' for Thyroid_hormone_metabolism,_abnormal,_3|Thyroid_hormone_metabolism,_abnormal_1. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0859354,MedGen:C5774292,OMIM:620198|MONDO:MONDO:0800046,MedGen:C5676891,OMIM:609698,Orphanet:171706. Review status: no assertion criteria provided.