A: The variant NC_000019.10:g.15551892dup in gene CYP4F22 is classified as 'Uncertain_significance' for Congenital_ichthyosiform_erythroderma. Molecular consequence: SO:0001624: 3_prime_UTR_variant. Variant type: Duplication. Disease database links: Human_Phenotype_Ontology:HP:0007431,Human_Phenotype_Ontology:HP:0007478,Human_Phenotype_Ontology:HP:0007484,MedGen:C0079583. Review status: criteria provided, single submitter.