A: The variant NC_000019.10:g.39386142G>A in gene PAF1 is classified as 'Uncertain_significance' for Peroxisome_biogenesis_disorder_1A_(Zellweger). Molecular consequence: SO:0001583: missense_variant,SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008953,MedGen:C4721541,OMIM:214100. Review status: criteria provided, single submitter.