A: The variant NC_000020.11:g.4699851G>C in gene PRNP is classified as 'Pathogenic' for Inherited_Creutzfeldt-Jakob_disease. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007403,MedGen:C0751254,OMIM:123400,Orphanet:204,Orphanet:282166,Orphanet:454700. Review status: no assertion criteria provided.