A: The variant NC_000019.10:g.15191795_15191839del in gene NOTCH3 is classified as 'Pathogenic' for Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1. Molecular consequence: SO:0001822: inframe_deletion. Variant type: Deletion. Disease database links: MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136. Review status: no assertion criteria provided.