A: The variant NC_000019.10:g.18596976C>T in gene CRLF1 is classified as 'Pathogenic' for Cold-induced_sweating_syndrome_1. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010091,MedGen:C1848947,OMIM:272430,Orphanet:1545,Orphanet:157820. Review status: criteria provided, single submitter.