A: The variant NC_000022.11:g.28724980del in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Familial_cancer_of_breast|Prostate_cancer|Colorectal_cancer|CHEK2-related_disorder|Hereditary_breast_ovarian_cancer_syndrome|Breast_and/or_ovarian_cancer|Hereditary_cancer-predisposing_syndrome|Malignant_tumor_of_breast|not_provided|Inherited_breast_cancer_and_ovarian_cancer. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|.|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MedGen:CN221562|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0007254,MedGen:C0006142|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.