A: The variant NC_000021.9:g.43755966G>A in gene PDXK is classified as 'Uncertain_significance' for not_specified|Neuropathy,_hereditary_motor_and_sensory,_type_VIc,_with_optic_atrophy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0032792,MedGen:C5193137,OMIM:618511. Review status: criteria provided, multiple submitters, no conflicts.