A: The variant NC_000021.9:g.45496605del in gene COL18A1 is classified as 'Benign' for Hereditary_glaucoma,_primary_closed-angle|Knobloch_syndrome|not_specified|not_provided. Molecular consequence: SO:0001627: intron_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0030038,MedGen:C5394374,OMIM:618880|MONDO:MONDO:0800166,MedGen:C1849409,OMIM:PS267750,Orphanet:1571|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.