A: The variant NC_000019.10:g.17826861G>A in gene JAK3 is classified as 'Uncertain_significance' for Severe_combined_immunodeficiency,_autosomal_recessive,_T_cell-negative,_B_cell-negative,_NK_cell-positive. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011086,MedGen:C1832322,OMIM:601457,Orphanet:331206. Review status: criteria provided, single submitter.