A: The variant NC_000020.11:g.45420629C>T in gene PIGT is classified as 'Benign/Likely_benign' for Multiple_congenital_anomalies-hypotonia-seizures_syndrome_3|Paroxysmal_nocturnal_hemoglobinuria_2|not_provided. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014165,MedGen:C3809356,OMIM:615398,Orphanet:369837|MONDO:MONDO:0014166,MedGen:C3809369,OMIM:615399,Orphanet:447|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.