A: The variant NC_000021.9:g.43753619G>A in gene PDXK is classified as 'Pathogenic' for Neuropathy,_hereditary_motor_and_sensory,_type_VIc,_with_optic_atrophy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032792,MedGen:C5193137,OMIM:618511. Review status: no assertion criteria provided.