A: The variant NC_000023.11:g.8539663C>T in gene ANOS1 is classified as 'Pathogenic/Likely_pathogenic' for Hypogonadotropic_hypogonadism_1_with_or_without_anosmia|Hypogonadotropic_hypogonadism. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010635,MedGen:C1563719,OMIM:308700,Orphanet:478|Human_Phenotype_Ontology:HP:0000044,Human_Phenotype_Ontology:HP:0003335,Human_Phenotype_Ontology:HP:0008224,MONDO:MONDO:0018555,MedGen:C0271623,OMIM:PS147950,Orphanet:432. Review status: criteria provided, multiple submitters, no conflicts.