A: The variant NC_000019.10:g.45352319G>A in gene ERCC2 is classified as 'Conflicting_classifications_of_pathogenicity' for Inborn_genetic_diseases|Leukodystrophy|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MeSH:D030342,MedGen:C0950123|Human_Phenotype_Ontology:HP:0002415,Human_Phenotype_Ontology:HP:0006926,Human_Phenotype_Ontology:HP:0007079,MONDO:MONDO:0019046,MedGen:C0023520,OMIM:PS312080,Orphanet:68356|MedGen:C3661900. Review status: criteria provided, conflicting classifications.