A: The variant NC_000021.9:g.43058851G>A in gene CBS is classified as 'Likely_benign' for not_provided|not_specified|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED|Familial_thoracic_aortic_aneurysm_and_aortic_dissection. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN169374|MedGen:C3150344|MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387. Review status: criteria provided, multiple submitters, no conflicts.