A: The variant NC_000021.9:g.43065605C>T in gene CBS is classified as 'Benign/Likely_benign' for Familial_thoracic_aortic_aneurysm_and_aortic_dissection|not_specified|Classic_homocystinuria|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED|not_provided. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387|MedGen:CN169374|MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394|MedGen:C3150344|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.