A: The variant NC_000019.10:g.46778904C>T in gene SLC1A5 is classified as 'Uncertain_significance' for Hereditary_spastic_paraplegia|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019064,MedGen:C0037773,OMIM:PS303350,Orphanet:685|MedGen:CN169374. Review status: criteria provided, single submitter.