A: The variant NC_000022.11:g.46335792G>T in gene TRMU is classified as 'Benign/Likely_benign' for not_specified|Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins|Aminoglycoside-induced_deafness|not_provided|Deafness,_mitochondrial,_modifier_of. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0013111,MedGen:C3278664,OMIM:613070,Orphanet:217371|MONDO:MONDO:0010799,MedGen:C1838854,OMIM:580000,Orphanet:168609|MedGen:C3661900|MedGen:C4017209. Review status: criteria provided, multiple submitters, no conflicts.