A: The variant NC_000021.9:g.25592837C>A in gene MRPL39 is classified as 'Likely_pathogenic' for Combined_oxidative_phosphorylation_deficiency_59|Mitochondrial_disease. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0957992,MedGen:C5882730,OMIM:620646|MONDO:MONDO:0044970,MeSH:D028361,MedGen:C0751651,Orphanet:68380. Review status: criteria provided, single submitter.