A: The variant NC_000019.10:g.50398839C>T in gene POLD1 is classified as 'Uncertain_significance' for Polymerase_proofreading-related_adenomatous_polyposis|Familial_colorectal_cancer_type_X|Carcinoma_of_colon. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018653,MedGen:C0130294,Orphanet:447877|MONDO:MONDO:0018604,MedGen:C3896578,Orphanet:440437|MONDO:MONDO:0002032,MedGen:C0699790. Review status: criteria provided, single submitter.