A: The variant NC_000019.10:g.17830213del in gene JAK3 is classified as 'Conflicting_classifications_of_pathogenicity' for T-B+_severe_combined_immunodeficiency_due_to_JAK3_deficiency|Severe_combined_immunodeficiency,_autosomal_recessive,_T_cell-negative,_B_cell-negative,_NK_cell-positive|Severe_combined_immunodeficiency_disease. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0010938,MedGen:C1833275,OMIM:600802,Orphanet:35078|MONDO:MONDO:0011086,MedGen:C1832322,OMIM:601457,Orphanet:331206|Human_Phenotype_Ontology:HP:0004430,MONDO:MONDO:0015974,MeSH:D016511,MedGen:C0085110,Orphanet:183660. Review status: criteria provided, conflicting classifications.