A: The variant NC_000020.11:g.33791327C>T in gene ZNF341 is classified as 'Uncertain_significance' for Hyper-IgE_recurrent_infection_syndrome_3,_autosomal_recessive|not_provided|not_specified. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032654,MedGen:C4748969,OMIM:618282|MedGen:C3661900|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.