A: The variant NC_000020.11:g.46596190G>T in gene SLC13A3 is classified as 'Pathogenic' for Leukoencephalopathy,_acute_reversible,_with_increased_urinary_alpha-ketoglutarate. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032716,MedGen:C5193068,OMIM:618384,Orphanet:615964. Review status: no assertion criteria provided.