A: The variant NC_000019.10:g.49836348G>A in gene MED25 is classified as 'Benign/Likely_benign' for Polyneuropathy|Congenital_cataract-microcephaly-nevus_flammeus_simplex-severe_intellectual_disability_syndrome|Charcot-Marie-Tooth_disease|not_provided|not_specified|Charcot-Marie-Tooth_disease_type_2. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0001271,Human_Phenotype_Ontology:HP:0006941,Human_Phenotype_Ontology:HP:0007287,MONDO:MONDO:0001824,MedGen:C0152025|MONDO:MONDO:0014643,MedGen:C4225323,OMIM:616449,Orphanet:464738|MONDO:MONDO:0015626,MedGen:C0007959,OMIM:PS118220,Orphanet:166|MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0018993,MedGen:C0270914,Orphanet:64746. Review status: criteria provided, multiple submitters, no conflicts.