A: The variant NC_000022.11:g.19962522T>A in gene COMT is classified as 'Uncertain_significance' for Schizophrenia|Panic_disorder_1. Molecular consequence: SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0100753,MONDO:MONDO:0005090,MeSH:D012559,MedGen:C0036341,OMIM:181500|MONDO:MONDO:0008187,MedGen:C1868649,OMIM:167870. Review status: criteria provided, single submitter.