A: The variant NC_000021.9:g.25891858G>C in gene APP is classified as 'Pathogenic' for Alzheimer_disease_type_1|Alzheimer_disease|not_provided|ABetaA21G_amyloidosis. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300|Human_Phenotype_Ontology:HP:0002511,Human_Phenotype_Ontology:HP:0006878,Human_Phenotype_Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020|MedGen:C3661900|MONDO:MONDO:0017948,MedGen:C3888307,Orphanet:324718. Review status: no assertion criteria provided.