A: The variant NC_000019.10:g.18783129G>A in gene COMP is classified as 'Pathogenic/Likely_pathogenic' for Carpal_tunnel_syndrome_2|Multiple_epiphyseal_dysplasia_type_1|Multiple_epiphyseal_dysplasia|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030883,MedGen:C5436916,OMIM:619161|MONDO:MONDO:0007561,MedGen:C1838280,OMIM:132400,Orphanet:93308|Human_Phenotype_Ontology:HP:0002654,MONDO:MONDO:0016648,MedGen:C0026760,OMIM:PS132400,Orphanet:251|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.