A: The variant NC_000020.11:g.44625670G>T in gene ADA is classified as 'Likely_pathogenic' for Severe_combined_immunodeficiency_disease|Severe_combined_immunodeficiency,_autosomal_recessive,_T_cell-negative,_B_cell-negative,_NK_cell-negative,_due_to_adenosine_deaminase_deficiency. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0004430,MONDO:MONDO:0015974,MeSH:D016511,MedGen:C0085110,Orphanet:183660|MONDO:MONDO:0007064,MedGen:C1863236,OMIM:102700,Orphanet:277. Review status: criteria provided, multiple submitters, no conflicts.