A: The variant NC_000020.11:g.33761916del in gene ZNF341 is classified as 'Pathogenic' for Hyper-IgE_recurrent_infection_syndrome_3,_autosomal_recessive. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0032654,MedGen:C4748969,OMIM:618282. Review status: no assertion criteria provided.