A: The variant NC_000022.11:g.28734401A>T in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Hereditary_cancer-predisposing_syndrome|Familial_cancer_of_breast|Prostate_cancer_susceptibility|Breast_cancer,_susceptibility_to|Malignant_tumor_of_breast|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Prostate_cancer|not_provided. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:C3469524|MedGen:C3469522|MONDO:MONDO:0007254,MedGen:C0006142|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.