A: The variant NC_000022.11:g.28703504C>G in gene CHEK2 is classified as 'Likely_pathogenic' for Familial_cancer_of_breast|Hereditary_breast_ovarian_cancer_syndrome. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145. Review status: criteria provided, multiple submitters, no conflicts.