A: The variant NC_000022.11:g.28710006_28712017del in gene CHEK2 is classified as 'Pathogenic' for CHEK2-related_cancer_predisposition. Molecular consequence: SO:0001574: splice_acceptor_variant,SO:0001575: splice_donor_variant,SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524. Review status: criteria provided, single submitter.