A: The variant NC_000022.11:g.28699866T>C in gene CHEK2 is classified as 'Uncertain_significance' for Familial_cancer_of_breast|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Prostate_cancer|CHEK2-related_disorder|not_provided|Breast_and/or_ovarian_cancer|Hereditary_cancer-predisposing_syndrome|Familial_prostate_cancer. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|.|MedGen:C3661900|MedGen:CN221562|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331. Review status: criteria provided, multiple submitters, no conflicts.