A: The variant NC_000021.9:g.25880545A>C in gene APP is classified as 'Likely_benign' for Early-onset_autosomal_dominant_Alzheimer_disease. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015140,MedGen:CN043596,Orphanet:1020. Review status: criteria provided, single submitter.