A: The variant NC_000021.9:g.36765008_36765020del in gene HLCS is classified as 'Likely_pathogenic' for Holocarboxylase_synthetase_deficiency. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242. Review status: criteria provided, single submitter.