A: The variant NC_000022.11:g.35333440G>A in gene TOM1 is classified as 'Uncertain_significance' for not_specified|Immunodeficiency_85_and_autoimmunity. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0030428,MedGen:C5561976,OMIM:619510. Review status: criteria provided, multiple submitters, no conflicts.