A: The variant NC_000020.11:g.49511026A>G in gene PTGIS is classified as 'Pathogenic' for Essential_hypertension. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0001134,MedGen:C0085580. Review status: no assertion criteria provided.