A: The variant NC_000019.10:g.38499646GAG[1] in gene RYR1 is classified as 'Likely_pathogenic|drug_response' for desflurane_response_-_Toxicity|Congenital_multicore_myopathy_with_external_ophthalmoplegia|RYR1-related_disorder|not_provided|succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|methoxyflurane_response_-_Toxicity|halothane_response_-_Toxicity|enflurane_response_-_Toxicity|Malignant_hyperthermia,_susceptibility_to,_1. Molecular consequence: SO:0001822: inframe_deletion. Variant type: Microsatellite. Disease database links: .|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|MedGen:CN239331|MedGen:C3661900|.|.|.|.|.|.|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423. Review status: reviewed by expert panel.