A: The variant NC_000020.11:g.35434220G>A in gene GDF5 is classified as 'Pathogenic' for Brachydactyly_type_A1C. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014032,MedGen:C3554446,OMIM:615072,Orphanet:93388. Review status: no assertion criteria provided.