A: The variant NC_000020.11:g.44624277del in gene ADA is classified as 'Pathogenic' for Severe_combined_immunodeficiency,_autosomal_recessive,_T_cell-negative,_B_cell-negative,_NK_cell-negative,_due_to_adenosine_deaminase_deficiency|Severe_combined_immunodeficiency_disease|ADA-related_disorder. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0007064,MedGen:C1863236,OMIM:102700,Orphanet:277|Human_Phenotype_Ontology:HP:0004430,MONDO:MONDO:0015974,MeSH:D016511,MedGen:C0085110,Orphanet:183660|.. Review status: reviewed by expert panel.