A: The variant NC_000021.9:g.43072166del in gene CBS is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Classic_homocystinuria|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MedGen:C3661900|MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394|MedGen:C3150344. Review status: criteria provided, multiple submitters, no conflicts.