A: The variant NC_000019.10:g.38457621A>G in gene RYR1 is classified as 'Uncertain_significance' for Central_core_myopathy|King_Denborough_syndrome|RYR1-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0020485,MedGen:C1840365,OMIM:619542|MedGen:CN239331. Review status: criteria provided, multiple submitters, no conflicts.