A: The variant NC_000019.10:g.38561237G>A in gene RYR1 is classified as 'Uncertain_significance' for not_provided|Congenital_myopathy_with_fiber_type_disproportion|Malignant_hyperthermia,_susceptibility_to,_1|King_Denborough_syndrome|Central_core_myopathy|Congenital_multicore_myopathy_with_external_ophthalmoplegia|RYR1-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0020485,MedGen:C1840365,OMIM:619542|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|MedGen:CN239331. Review status: criteria provided, multiple submitters, no conflicts.