A: The variant NC_000022.11:g.20992793G>A in gene LZTR1 is classified as 'Likely_pathogenic' for Noonan_syndrome_2. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648. Review status: criteria provided, single submitter.