A: The variant NC_000019.10:g.38499961T>A in gene RYR1 is classified as 'Conflicting_classifications_of_pathogenicity' for Central_core_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|Congenital_myopathy_with_fiber_type_disproportion|Congenital_multicore_myopathy_with_external_ophthalmoplegia|EMG_abnormality|Clubfoot|Lower_limb_amyotrophy|King_Denborough_syndrome|RYR1-related_disorder|not_provided|Neuromuscular_disease. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|Human_Phenotype_Ontology:HP:0002177,Human_Phenotype_Ontology:HP:0003457,Human_Phenotype_Ontology:HP:0003751,Human_Phenotype_Ontology:HP:0003753,Human_Phenotype_Ontology:HP:0100286,MedGen:C0476403|Human_Phenotype_Ontology:HP:0001762,MONDO:MONDO:0007342,MedGen:C0009081,OMIM:119800,Orphanet:199315|Human_Phenotype_Ontology:HP:0007210,MedGen:C4024921|MONDO:MONDO:0020485,MedGen:C1840365,OMIM:619542|MedGen:CN239331|MedGen:C3661900|MONDO:MONDO:0019056,MeSH:D009468,MedGen:C0027868,Orphanet:68381. Review status: criteria provided, conflicting classifications.