A: The variant NC_000019.10:g.23361341G>C in gene ZNF91 is classified as 'Uncertain_significance' for Cataract|Microphthalmia|Retinal_dystrophy|Microcephaly|Congenital_nephrotic_syndrome. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000518,MONDO:MONDO:0005129,MeSH:D002386,MedGen:C0086543,OMIM:PS116200|Human_Phenotype_Ontology:HP:0000568,Human_Phenotype_Ontology:HP:0007996,MONDO:MONDO:0021129,MedGen:C0026010|Human_Phenotype_Ontology:HP:0000556,Human_Phenotype_Ontology:HP:0007736,Human_Phenotype_Ontology:HP:0007910,Human_Phenotype_Ontology:HP:0007974,Human_Phenotype_Ontology:HP:0007982,MONDO:MONDO:0019118,MeSH:D058499,MedGen:C0854723,Orphanet:71862|Human_Phenotype_Ontology:HP:0000252,Human_Phenotype_Ontology:HP:0001366,Human_Phenotype_Ontology:HP:0005485,Human_Phenotype_Ontology:HP:0005489,Human_Phenotype_Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563|Human_Phenotype_Ontology:HP:0008677,MONDO:MONDO:0002350,MeSH:C535761,MedGen:C3501848,OMIM:PS256300. Review status: criteria provided, single submitter.