A: The variant NC_000021.9:g.36937092_36937093del in gene HLCS is classified as 'Likely_pathogenic' for Holocarboxylase_synthetase_deficiency. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242. Review status: criteria provided, single submitter.