A: The variant NC_000019.10:g.45553721_45553723del in gene OPA3 is classified as 'Uncertain_significance' for 3-Methylglutaconic_aciduria_type_3. Molecular consequence: SO:0001627: intron_variant,SO:0001822: inframe_deletion. Variant type: Deletion. Disease database links: MONDO:MONDO:0009787,MedGen:C0574084,OMIM:258501,Orphanet:67047. Review status: criteria provided, single submitter.