A: The variant NC_000019.10:g.50408800del in gene POLD1 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome|not_specified. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.