A: The variant NC_000020.11:g.46118275del in gene CD40 is classified as 'Benign/Likely_benign' for Hyperimmunoglobulin_M_syndrome|not_provided. Variant type: Deletion. Disease database links: MONDO:MONDO:0003947,MedGen:C0272236,OMIM:PS308230|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.