A: The variant NC_000020.11:g.13816520T>G in gene NDUFAF5 is classified as 'Pathogenic/Likely_pathogenic' for Mitochondrial_complex_I_deficiency|Mitochondrial_complex_1_deficiency,_nuclear_type_16|Inborn_genetic_diseases|Leigh_syndrome|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0100133,MedGen:C1838979,Orphanet:2609|MONDO:MONDO:0032621,MedGen:C4748785,OMIM:618238|MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0009723,MedGen:C2931891,OMIM:256000,Orphanet:506|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.