A: The variant NC_000021.9:g.31667353dup in gene SOD1 is classified as 'Likely_pathogenic' for Spastic_tetraplegia_and_axial_hypotonia,_progressive|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0032828,MedGen:C5231422,OMIM:618598|MedGen:C3661900. Review status: criteria provided, single submitter.