A: The variant NC_000022.11:g.28694110G>C in gene CHEK2 is classified as 'Uncertain_significance' for Familial_cancer_of_breast|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_prostate_cancer|Malignant_tumor_of_breast|Hereditary_cancer-predisposing_syndrome|not_specified|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0007254,MedGen:C0006142|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.