A: The variant NC_000019.10:g.38572185G>A in gene RYR1 is classified as 'Uncertain_significance' for Central_core_myopathy|Malignant_hyperthermia_of_anesthesia|RYR1-related_disorder|Congenital_myopathy_with_fiber_type_disproportion|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|MedGen:CN239331|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020|MedGen:C3661900. Review status: reviewed by expert panel.