A: The variant NC_000021.9:g.36946105C>T in gene HLCS is classified as 'Benign/Likely_benign' for Holocarboxylase_synthetase_deficiency|not_provided. Molecular consequence: SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.