A: The variant NC_000021.9:g.42388532C>T in gene TMPRSS3 is classified as 'Pathogenic/Likely_pathogenic' for Rare_genetic_deafness|Hearing_loss,_autosomal_recessive|Autosomal_recessive_nonsyndromic_hearing_loss_8|Hearing_impairment|not_provided|Childhood_onset_hearing_loss|TMPRSS3-related_disorder. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C5680250,Orphanet:96210|MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636|MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636|Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666|MedGen:C3661900|.|.. Review status: criteria provided, multiple submitters, no conflicts.