A: The variant NC_000020.11:g.59019557del in gene TUBB1 is classified as 'Conflicting_classifications_of_pathogenicity' for TUBB1-related_disorder|Macrothrombocytopenia,_isolated,_1,_autosomal_dominant|Congenital_hypothyroidism|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: .|MONDO:MONDO:0800047,MedGen:C5676892,OMIM:613112,Orphanet:140957|Human_Phenotype_Ontology:HP:0000851,MONDO:MONDO:0018612,MedGen:C0010308,Orphanet:442|MedGen:C3661900. Review status: criteria provided, conflicting classifications.