A: The variant NC_000022.11:g.28725013T>G in gene CHEK2 is classified as 'Conflicting_classifications_of_pathogenicity' for Predisposition_to_cancer|Familial_cancer_of_breast|CHEK2-related_disorder|Endometrial_carcinoma|Hereditary_cancer-predisposing_syndrome|not_specified|Hereditary_breast_ovarian_cancer_syndrome|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Prostate_cancer|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: .|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|.|Human_Phenotype_Ontology:HP:0012114,MONDO:MONDO:0002447,MedGen:C0476089,OMIM:608089|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MedGen:C3661900. Review status: criteria provided, conflicting classifications.