A: The variant NC_000022.11:g.50084862C>T in gene MLC1 is classified as 'Uncertain_significance' for Megalencephalic_leukoencephalopathy_with_subcortical_cysts_1|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0024555,MedGen:C5779875,OMIM:604004,Orphanet:2478|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.