A: The variant NC_000020.11:g.36930783A>T in gene SAMHD1 is classified as 'Pathogenic/Likely_pathogenic' for Chilblain_lupus_2|Aicardi_Goutieres_syndrome|Aicardi-Goutieres_syndrome_5|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013739,MedGen:C3280721,OMIM:614415|MONDO:MONDO:0018866,MedGen:C0393591,OMIM:PS225750,Orphanet:51|MONDO:MONDO:0013059,MedGen:C2749659,OMIM:612952,Orphanet:51|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.