A: The variant NC_000020.11:g.32793610T>C in gene DNMT3B is classified as 'Benign/Likely_benign' for Centromeric_instability_of_chromosomes_1,9_and_16_and_immunodeficiency|Immunodeficiency-centromeric_instability-facial_anomalies_syndrome_1. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0000133,MedGen:C0398788,OMIM:PS242860,Orphanet:2268|MONDO:MONDO:0009454,MedGen:C4551557,OMIM:242860,Orphanet:2268. Review status: criteria provided, multiple submitters, no conflicts.