A: The variant NC_000020.11:g.58909991dup in gene GNAS is classified as 'Likely_pathogenic' for Progressive_osseous_heteroplasia. Molecular consequence: SO:0001589: frameshift_variant,SO:0001624: 3_prime_UTR_variant. Variant type: Duplication. Disease database links: Human_Phenotype_Ontology:HP:0025027,MONDO:MONDO:0008153,MedGen:C0334041,OMIM:166350,Orphanet:2762. Review status: criteria provided, single submitter.