A: The variant NC_000022.11:g.20992304C>T in gene LZTR1 is classified as 'Likely_pathogenic' for RASopathy|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|Noonan_syndrome_2|Noonan_syndrome_and_Noonan-related_syndrome|Schwannomatosis|LZTR1-related_schwannomatosis|not_provided|Noonan_syndrome_10|Short_stature|See_cases. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|MONDO:MONDO:0020297,MedGen:C5681679,Orphanet:98733|MONDO:MONDO:0008075,MeSH:C536641,MedGen:C1335929,OMIM:PS162091,Orphanet:93921|MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921|MedGen:C3661900|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648|Human_Phenotype_Ontology:HP:0001509,Human_Phenotype_Ontology:HP:0003501,Human_Phenotype_Ontology:HP:0003507,Human_Phenotype_Ontology:HP:0003512,Human_Phenotype_Ontology:HP:0003518,Human_Phenotype_Ontology:HP:0003519,Human_Phenotype_Ontology:HP:0004322,Human_Phenotype_Ontology:HP:0008871,Human_Phenotype_Ontology:HP:0008882,Human_Phenotype_Ontology:HP:0008888,Human_Phenotype_Ontology:HP:0008913,MedGen:C0349588|.. Review status: reviewed by expert panel.