A: The variant NC_000020.11:g.35434611_35434633dup in gene GDF5 is classified as 'Pathogenic/Likely_pathogenic' for Multiple_synostoses_syndrome_2|Acromesomelic_dysplasia_2B|Type_A2_brachydactyly|Osteoarthritis_susceptibility_5|Acromesomelic_dysplasia_2C,_Hunter-Thompson_type|Grebe_syndrome|Brachydactyly_type_A1C|Symphalangism,_proximal,_1B|Brachydactyly_type_C|not_provided. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0012394,MedGen:C1832708,OMIM:610017,Orphanet:3237|MONDO:MONDO:0009231,MedGen:C1856738,OMIM:228900,Orphanet:2639|Human_Phenotype_Ontology:HP:0009372,MONDO:MONDO:0007216,MedGen:C1832702,OMIM:112600,Orphanet:93396|MONDO:MONDO:0012893,MedGen:C4759728,OMIM:612400|MONDO:MONDO:0008717,MedGen:C2930970,OMIM:201250,Orphanet:968|MONDO:MONDO:0008703,MedGen:C0265260,OMIM:200700,Orphanet:2098|MONDO:MONDO:0014032,MedGen:C3554446,OMIM:615072,Orphanet:93388|MONDO:MONDO:0014125,MedGen:C3809104,OMIM:615298,Orphanet:3250|Human_Phenotype_Ontology:HP:0009373,MONDO:MONDO:0007221,MedGen:C1862103,OMIM:113100,Orphanet:93384|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.