A: The variant NC_000019.10:g.15161407G>A in gene NOTCH3 is classified as 'Benign' for Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|Pulmonary_arterial_hypertension|not_specified|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|Human_Phenotype_Ontology:HP:0002092,Human_Phenotype_Ontology:HP:0006546,MONDO:MONDO:0015924,MeSH:D000081029,MedGen:C2973725,Orphanet:182090|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.