A: The variant NC_000019.10:g.45494273A>G in gene RTN2 is classified as 'Uncertain_significance' for Spastic_paraplegia. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0001258,Human_Phenotype_Ontology:HP:0007062,Human_Phenotype_Ontology:HP:0007124,Human_Phenotype_Ontology:HP:0007216,MedGen:C0037772. Review status: criteria provided, single submitter.