A: The variant NC_000022.11:g.28710060C>T in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Hereditary_cancer-predisposing_syndrome|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_cancer_of_breast|Prostate_cancer|Colorectal_cancer|Hereditary_breast_ovarian_cancer_syndrome|Familial_prostate_cancer|not_provided. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.