A: The variant NC_000020.11:g.63350755T>G in gene CHRNA4 is classified as 'Uncertain_significance' for Autosomal_dominant_nocturnal_frontal_lobe_epilepsy|Amyotrophic_lateral_sclerosis. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0020300,MedGen:C3696898,Orphanet:98784|Human_Phenotype_Ontology:HP:0007354,MONDO:MONDO:0004976,MedGen:C0002736,Orphanet:803. Review status: criteria provided, multiple submitters, no conflicts.