A: The variant NC_000022.11:g.28719418_28719419del in gene CHEK2 is classified as 'Likely_pathogenic' for Breast_carcinoma. Molecular consequence: SO:0001589: frameshift_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222. Review status: no assertion criteria provided.