A: The variant NC_000022.11:g.19963748G>A in gene COMT is classified as 'Benign' for not_provided|Tramadol_response|not_specified|Schizophrenia|CATECHOL-O-METHYLTRANSFERASE_POLYMORPHISM. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN078023|MedGen:CN169374|Human_Phenotype_Ontology:HP:0100753,MONDO:MONDO:0005090,MeSH:D012559,MedGen:C0036341,OMIM:181500|.. Review status: criteria provided, multiple submitters, no conflicts.