A: The variant NC_000020.11:g.8729117C>T in gene PLCB1 is classified as 'Uncertain_significance' for Developmental_and_epileptic_encephalopathy,_12. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013389,MedGen:C3150988,OMIM:613722. Review status: criteria provided, single submitter.