A: The variant NC_000019.10:g.49640030dup in gene RRAS is classified as 'Uncertain_significance' for Noonan_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0018997,MeSH:D009634,MedGen:C0028326,OMIM:PS163950,Orphanet:648. Review status: criteria provided, single submitter.