A: The variant NC_000021.9:g.26051129T>C in gene APP is classified as 'Uncertain_significance' for Alzheimer_disease. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002511,Human_Phenotype_Ontology:HP:0006878,Human_Phenotype_Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020. Review status: criteria provided, single submitter.