A: The variant NC_000020.11:g.4699533C>T in gene PRNP is classified as 'Uncertain_significance' for Gerstmann-Straussler-Scheinker_syndrome|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007656,MedGen:C0017495,OMIM:137440,Orphanet:356|MedGen:C3661900. Review status: criteria provided, single submitter.