A: The variant NC_000019.10:g.17830202A>G in gene JAK3 is classified as 'Uncertain_significance' for T-B+_severe_combined_immunodeficiency_due_to_JAK3_deficiency. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010938,MedGen:C1833275,OMIM:600802,Orphanet:35078. Review status: criteria provided, single submitter.