A: The variant NC_000022.11:g.50731088C>T in gene SHANK3 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|SHANK3-related_disorder. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.