A: The variant NC_000019.10:g.49399142G>A in gene KASH5 is classified as 'Likely_pathogenic' for Genetic_non-acquired_premature_ovarian_failure|Premature_ovarian_failure_22. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C5925042,Orphanet:485382|MONDO:MONDO:0957822,MedGen:C5882707,OMIM:620548. Review status: criteria provided, single submitter.