A: The variant NC_000020.11:g.63305935C>G in gene COL20A1 is classified as 'Uncertain_significance' for Palmoplantar_keratoderma_i,_striate,_focal,_or_diffuse. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007859,MedGen:C2931122,OMIM:148700,Orphanet:369999,Orphanet:370002. Review status: no assertion criteria provided.