A: The variant NC_000019.10:g.19197496_19197521del in gene RFXANK is classified as 'Pathogenic' for MHC_class_II_deficiency_2|MHC_class_II_deficiency_1|not_provided|MHC_class_II_deficiency. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0971013,MedGen:C1859535,OMIM:620815|MONDO:MONDO:0971005,MedGen:CN377826,OMIM:209920|MedGen:C3661900|MONDO:MONDO:0008855,MedGen:C5447452,OMIM:PS209920,Orphanet:572. Review status: criteria provided, multiple submitters, no conflicts.