A: The variant NC_000022.11:g.28710031A>G in gene CHEK2 is classified as 'Uncertain_significance' for Hereditary_nonpolyposis_colon_cancer. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018630,MedGen:C1333990,OMIM:PS120435,Orphanet:443909. Review status: criteria provided, single submitter.