A: The variant NC_000022.11:g.28734590G>T in gene CHEK2 is classified as 'Uncertain_significance' for CHEK2-related_cancer_predisposition|Familial_prostate_cancer|Bone_osteosarcoma. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668. Review status: criteria provided, single submitter.