A: The variant NC_000022.11:g.20994627_20994644dup in gene LZTR1 is classified as 'Uncertain_significance' for not_provided|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|Noonan_syndrome_10. Molecular consequence: SO:0001821: inframe_insertion. Variant type: Duplication. Disease database links: MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648. Review status: criteria provided, multiple submitters, no conflicts.