A: The variant NC_000022.11:g.28725090A>T in gene CHEK2 is classified as 'Uncertain_significance' for CHEK2-related_cancer_predisposition. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524. Review status: criteria provided, single submitter.