A: The variant NC_000019.10:g.15192005A>G in gene NOTCH3 is classified as 'Pathogenic' for Migraine|Ischemic_stroke|Abnormal_cerebral_white_matter_morphology|Migraine_with_aura|Depression|Atypical_behavior|Cognitive_impairment. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002076,Human_Phenotype_Ontology:HP:0007194,MONDO:MONDO:0005277,MedGen:C0149931|Human_Phenotype_Ontology:HP:0002140,MedGen:C0948008,OMIM:601367|Human_Phenotype_Ontology:HP:0002500,Human_Phenotype_Ontology:HP:0200100,MedGen:C0948163|Human_Phenotype_Ontology:HP:0002077,MONDO:MONDO:0005475,MedGen:C0154723|Human_Phenotype_Ontology:HP:0000716,MONDO:MONDO:0002050,MeSH:D003866,MedGen:C0011581|Human_Phenotype_Ontology:HP:0000708,Human_Phenotype_Ontology:HP:0000715,Human_Phenotype_Ontology:HP:0002368,Human_Phenotype_Ontology:HP:0002456,MedGen:C0004941|Human_Phenotype_Ontology:HP:0002128,Human_Phenotype_Ontology:HP:0002129,Human_Phenotype_Ontology:HP:0002302,Human_Phenotype_Ontology:HP:0002337,Human_Phenotype_Ontology:HP:0002441,Human_Phenotype_Ontology:HP:0006972,Human_Phenotype_Ontology:HP:0006998,Human_Phenotype_Ontology:HP:0007211,Human_Phenotype_Ontology:HP:0100543,MedGen:C0338656. Review status: no assertion criteria provided.