A: The variant NC_000021.9:g.25599863del in gene MRPL39 is classified as 'Likely_pathogenic' for Combined_oxidative_phosphorylation_deficiency_59|Leigh_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0957992,MedGen:C5882730,OMIM:620646|MONDO:MONDO:0009723,MedGen:C2931891,OMIM:256000,Orphanet:506. Review status: criteria provided, single submitter.