A: The variant NC_000022.11:g.28719396T>A in gene CHEK2 is classified as 'Uncertain_significance' for Hereditary_cancer-predisposing_syndrome|Bone_osteosarcoma|Familial_prostate_cancer|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, multiple submitters, no conflicts.