A: The variant NC_000021.9:g.45477474dup in gene COL18A1 is classified as 'Pathogenic/Likely_pathogenic' for Hereditary_glaucoma,_primary_closed-angle|not_provided. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0030038,MedGen:C5394374,OMIM:618880|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.