A: The variant NC_000021.9:g.43068610T>A in gene CBS is classified as 'Conflicting_classifications_of_pathogenicity' for Connective_tissue_disorder|Classic_homocystinuria|not_provided|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED|Familial_thoracic_aortic_aneurysm_and_aortic_dissection|CBS-related_disorder|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0003900,MedGen:C0009782|MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394|MedGen:C3661900|MedGen:C3150344|MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387|.|MedGen:CN169374. Review status: criteria provided, conflicting classifications.