A: The variant NC_000022.11:g.21788350T>C in gene MAPK1 is classified as 'Likely_pathogenic' for Noonan_syndrome_13. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0033669,MedGen:C5436773,OMIM:619087. Review status: criteria provided, single submitter.