A: The variant NC_000019.10:g.15188277A>C in gene NOTCH3 is classified as 'Likely_pathogenic' for Migraine|Tension-type_headache|Transient_ischemic_attack|Abnormal_brain_morphology. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002076,Human_Phenotype_Ontology:HP:0007194,MONDO:MONDO:0005277,MedGen:C0149931|Human_Phenotype_Ontology:HP:0012228,MedGen:C0033893|Human_Phenotype_Ontology:HP:0002326,MONDO:MONDO:0005264,MedGen:C0007787|Human_Phenotype_Ontology:HP:0012443,MedGen:C4021085. Review status: criteria provided, single submitter.