A: The variant NC_000020.11:g.23048148C>T in gene THBD is classified as 'Uncertain_significance' for Abnormal_bleeding|Thrombomodulin-related_bleeding_disorder|Atypical_hemolytic-uremic_syndrome_with_thrombomodulin_anomaly. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0001892,Human_Phenotype_Ontology:HP:0004830,Human_Phenotype_Ontology:HP:0004834,Human_Phenotype_Ontology:HP:0004849,Human_Phenotype_Ontology:HP:0004862,Human_Phenotype_Ontology:HP:0004865,Human_Phenotype_Ontology:HP:0008183,MedGen:C1458140|MONDO:MONDO:0013775,MedGen:C3280976,OMIM:614486,Orphanet:436169|MONDO:MONDO:0013044,MedGen:C2752036,OMIM:612926. Review status: criteria provided, multiple submitters, no conflicts.