A: The variant NC_000022.11:g.20990476G>A in gene LZTR1 is classified as 'Likely_pathogenic' for LZTR1-related_schwannomatosis|Fetal_cystic_hygroma|Cardiovascular_phenotype|Hereditary_cancer-predisposing_syndrome|Noonan_syndrome_10|not_provided|Noonan_syndrome_1|RASopathy|LZTR1-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921|Human_Phenotype_Ontology:HP:0010878,MedGen:C0948242,OMIM:257350,Orphanet:79486|MedGen:CN230736|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648|MedGen:C3661900|MONDO:MONDO:0008104,MedGen:C4551602,OMIM:163950,Orphanet:648|MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|.. Review status: reviewed by expert panel.