A: The variant NC_000019.10:g.41348412C>T in gene TGFB1 is classified as 'Uncertain_significance' for Inflammatory_bowel_disease,_immunodeficiency,_and_encephalopathy|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032601,MedGen:C4748708,OMIM:618213,Orphanet:565788|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.