A: The variant NC_000022.11:g.41173761G>T in gene EP300 is classified as 'Conflicting_classifications_of_pathogenicity' for Menke-Hennekam_syndrome_2|Rubinstein-Taybi_syndrome_due_to_EP300_haploinsufficiency|Colorectal_cancer. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0020769,MedGen:C5193035,OMIM:618333|MONDO:MONDO:0013364,MedGen:C3150941,OMIM:613684,Orphanet:353284,Orphanet:783|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500. Review status: criteria provided, conflicting classifications.