A: The variant NC_000022.11:g.28695786C>G in gene CHEK2 is classified as 'Uncertain_significance' for Familial_cancer_of_breast|CHEK2-related_disorder|not_provided|Hereditary_cancer-predisposing_syndrome|Breast_and/or_ovarian_cancer|Hereditary_breast_ovarian_cancer_syndrome|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|.|MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN221562|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.