A: The variant NC_000022.11:g.28695869del in gene CHEK2 is classified as 'Pathogenic' for Carcinoma_of_pancreas|Breast_and_colorectal_cancer,_susceptibility_to|not_provided|CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_cancer_of_breast|Prostate_cancer|Li-Fraumeni_syndrome_1|Astrocytoma|Hereditary_cancer-predisposing_syndrome|CHEK2-related_disorder|Inherited_breast_cancer_and_ovarian_cancer|NICE_approved_PARP_inhibitor_treatment|Predisposition_to_cancer|Malignant_tumor_of_breast|Breast_cancer,_susceptibility_to|Breast_neoplasm|Breast_carcinoma|Colorectal_cancer|Breast_and/or_ovarian_cancer|Ovarian_neoplasm|Familial_prostate_cancer|Li-Fraumeni_syndrome|Hereditary_breast_ovarian_cancer_syndrome|TUMOR_PREDISPOSITION_SYNDROME_4,_BREAST/PROSTATE/COLORECTAL|Breast-ovarian_cancer,_familial,_susceptibility_to,_1|Leiomyosarcoma. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0005192,MeSH:C562463,MedGen:C0235974,Orphanet:1333,Orphanet:217074|MedGen:CN068920|MedGen:C3661900|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|Gene:553989,MedGen:C1835398,OMIM:151623,Orphanet:524|Human_Phenotype_Ontology:HP:0009592,MONDO:MONDO:0019781,MeSH:D001254,MedGen:C0004114|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|.|.|.|.|MONDO:MONDO:0007254,MedGen:C0006142|MedGen:C3469522|Human_Phenotype_Ontology:HP:0010623,Human_Phenotype_Ontology:HP:0100013,MONDO:MONDO:0021100,MeSH:D001943,MedGen:C1458155|Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MedGen:CN221562|Human_Phenotype_Ontology:HP:0100615,MONDO:MONDO:0021068,MeSH:D010051,MedGen:C0919267|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0018875,MedGen:C0085390,OMIM:PS151623,Orphanet:524|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|.|MONDO:MONDO:0011450,MedGen:C2676676,OMIM:604370,Orphanet:145|Human_Phenotype_Ontology:HP:0100243,MONDO:MONDO:0005058,MedGen:C0023269,Orphanet:64720. Review status: criteria provided, multiple submitters, no conflicts.