A: The variant NC_000023.11:g.8539744G>A in gene ANOS1 is classified as 'Pathogenic/Likely_pathogenic' for Hypogonadotropic_hypogonadism_1_with_or_without_anosmia|Hypogonadotropic_hypogonadism_7_with_or_without_anosmia|Delayed_puberty. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0010635,MedGen:C1563719,OMIM:308700,Orphanet:478|MONDO:MONDO:0007794,MedGen:C0342384,OMIM:146110,Orphanet:432|Human_Phenotype_Ontology:HP:0000823,Human_Phenotype_Ontology:HP:0008859,Human_Phenotype_Ontology:HP:0010466,Human_Phenotype_Ontology:HP:0010467,MedGen:C0034012. Review status: criteria provided, multiple submitters, no conflicts.