A: The variant NC_000020.11:g.13817201dup in gene NDUFAF5 is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Mitochondrial_complex_I_deficiency,_nuclear_type_1|Mitochondrial_complex_1_deficiency,_nuclear_type_16|Leber_plus_disease. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: MedGen:C3661900|MONDO:MONDO:0100224,MedGen:CN257533,OMIM:252010|MONDO:MONDO:0032621,MedGen:C4748785,OMIM:618238|MONDO:MONDO:0020478,MedGen:C4304725,Orphanet:99718. Review status: criteria provided, conflicting classifications.