A: The variant NC_000022.11:g.21962760G>A in gene TOP3B is classified as 'Benign' for not_provided|TOP3B-related_disorder. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|.. Review status: criteria provided, single submitter.