A: The variant NC_000021.9:g.45488441T>C in gene COL18A1 is classified as 'Benign' for not_specified|Hereditary_glaucoma,_primary_closed-angle|not_provided|Knobloch_syndrome. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MONDO:MONDO:0030038,MedGen:C5394374,OMIM:618880|MedGen:C3661900|MONDO:MONDO:0800166,MedGen:C1849409,OMIM:PS267750,Orphanet:1571. Review status: criteria provided, multiple submitters, no conflicts.