A: The variant NC_000019.10:g.45494912dup in gene RTN2 is classified as 'Pathogenic' for Neuronopathy,_distal_hereditary_motor,_autosomal_recessive_11,_with_spasticity|Hereditary_spastic_paraplegia_12. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0971150,MedGen:C5935630,OMIM:620854|MONDO:MONDO:0011489,MedGen:C1858106,OMIM:604805,Orphanet:100993. Review status: no assertion criteria provided.