A: The variant NC_000019.10:g.18606656T>C in gene CRLF1 is classified as 'Likely_pathogenic' for Cold-induced_sweating_syndrome. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0015526,MedGen:C1832409,OMIM:PS272430,Orphanet:157820. Review status: criteria provided, single submitter.