A: The variant NC_000019.10:g.15540537_15540538del in gene CYP4F22 is classified as 'Likely_pathogenic' for Lamellar_ichthyosis. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0017778,MedGen:C5848247,Orphanet:313. Review status: criteria provided, single submitter.