A: The variant NC_000022.11:g.28734673C>A in gene CHEK2 is classified as 'Pathogenic' for Bone_osteosarcoma. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668. Review status: no assertion criteria provided.