A: The variant NC_000022.11:g.28712018C>T in gene CHEK2 is classified as 'Likely_pathogenic' for Gastric_cancer|Hereditary_cancer-predisposing_syndrome|Familial_cancer_of_breast|not_provided|Breast_and/or_ovarian_cancer. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0012126,MONDO:MONDO:0001056,MeSH:D013274,MedGen:C0024623,OMIM:613659|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MedGen:C3661900|MedGen:CN221562. Review status: criteria provided, multiple submitters, no conflicts.