A: The variant NC_000022.11:g.41149880G>A in gene EP300 is classified as 'Benign/Likely_benign' for Rubinstein-Taybi_syndrome_due_to_EP300_haploinsufficiency|not_specified|not_provided|Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations|Menke-Hennekam_syndrome_2|Colorectal_cancer. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013364,MedGen:C3150941,OMIM:613684,Orphanet:353284,Orphanet:783|MedGen:CN169374|MedGen:C3661900|MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783|MONDO:MONDO:0020769,MedGen:C5193035,OMIM:618333|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500. Review status: criteria provided, multiple submitters, no conflicts.