A: The variant NC_000021.9:g.43063062_43063063insATCCACCCCAATGATCTGCAGAGGGCGCGGCTTCAGGGCTCAAGCCCAGCAAAAGCCCCACCTGGATG in gene CBS is classified as 'Likely_benign' for Classic_homocystinuria|Familial_thoracic_aortic_aneurysm_and_aortic_dissection. Molecular consequence: SO:0001587: nonsense,SO:0001821: inframe_insertion. Variant type: Insertion. Disease database links: MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394|MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387. Review status: criteria provided, single submitter.