A: The variant NC_000022.11:g.28724974T>A in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Prostate_cancer|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast|CHEK2-related_disorder|not_provided|Breast_carcinoma|Malignant_tumor_of_breast|Hereditary_cancer-predisposing_syndrome|Hereditary_breast_ovarian_cancer_syndrome|Bone_osteosarcoma|Familial_prostate_cancer. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|.|MedGen:C3661900|Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222|MONDO:MONDO:0007254,MedGen:C0006142|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331. Review status: criteria provided, multiple submitters, no conflicts.