A: The variant NC_000021.9:g.46216420G>A in gene LSS is classified as 'Benign/Likely_benign' for Cataract_44|Hypotrichosis_14|Alopecia-intellectual_disability_syndrome_4|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014673,MedGen:C4225300,OMIM:616509,Orphanet:91492,Orphanet:98994|MONDO:MONDO:0032649,MedGen:C4748930,OMIM:618275|MONDO:MONDO:0030009,MedGen:C5394241,OMIM:618840|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.