A: The variant NC_000019.10:g.49398104T>C in gene KASH5 is classified as 'Pathogenic' for Spermatogenic_failure_88|Premature_ovarian_failure_22. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0957821,MedGen:C5882706,OMIM:620547|MONDO:MONDO:0957822,MedGen:C5882707,OMIM:620548. Review status: no assertion criteria provided.