A: The variant NC_000022.11:g.28689133_28689216del in gene CHEK2 is classified as 'Uncertain_significance' for Malignant_tumor_of_breast. Molecular consequence: SO:0001574: splice_acceptor_variant,SO:0001575: splice_donor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0007254,MedGen:C0006142. Review status: no assertion criteria provided.