A: The variant NC_000022.11:g.20982398del in gene LZTR1 is classified as 'Pathogenic' for LZTR1-related_schwannomatosis|not_provided|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|Noonan_syndrome_2|Noonan_syndrome_10. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921|MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648. Review status: criteria provided, multiple submitters, no conflicts.