A: The variant NC_000022.11:g.21867421GCC[8] in gene MAPK1 is classified as 'Uncertain_significance' for not_provided|MAPK1-related_disorder. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001820: inframe_indel,SO:0001821: inframe_insertion. Variant type: Microsatellite. Disease database links: MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.