A: The variant NC_000019.10:g.38467633T>C in gene RYR1 is classified as 'Uncertain_significance' for RYR1-related_disorder|Malignant_hyperthermia,_susceptibility_to,_1|Osteoporosis|Myotonia|Mildly_elevated_creatine_kinase|Limb_pain. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN239331|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|Human_Phenotype_Ontology:HP:0000939,Human_Phenotype_Ontology:HP:0002774,MONDO:MONDO:0005298,MedGen:C0029456,OMIM:166710|Human_Phenotype_Ontology:HP:0002486,Human_Phenotype_Ontology:HP:0003632,Human_Phenotype_Ontology:HP:0003754,Human_Phenotype_Ontology:HP:0003792,MedGen:C0700153|Human_Phenotype_Ontology:HP:0003211,Human_Phenotype_Ontology:HP:0008180,MedGen:C1850309|Human_Phenotype_Ontology:HP:0009763,MedGen:C0030196. Review status: criteria provided, multiple submitters, no conflicts.