A: The variant NC_000019.10:g.38580054C>T in gene RYR1 is classified as 'Pathogenic/Likely_pathogenic' for Abnormality_of_the_musculature|RYR1-related_disorder|RYR1-related_myopathy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0003011,Human_Phenotype_Ontology:HP:0003197,Human_Phenotype_Ontology:HP:0003708,MedGen:C4021745|MedGen:CN239331|MONDO:MONDO:0100150,MedGen:CN305348. Review status: criteria provided, multiple submitters, no conflicts.