A: The variant NC_000022.11:g.28734664G>A in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for CHEK2-related_cancer_predisposition|Bone_osteosarcoma|Familial_cancer_of_breast|Familial_prostate_cancer|Inherited_breast_cancer_and_ovarian_cancer|Breast_carcinoma|Hereditary_cancer-predisposing_syndrome|not_specified|Familial_ovarian_cancer|not_provided. Molecular consequence: SO:0001587: nonsense,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|.|Human_Phenotype_Ontology:HP:0003002,MONDO:MONDO:0004989,MedGen:C0678222|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374|MONDO:MONDO:0016248,MedGen:C5679802,Orphanet:213517|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.