A: The variant NC_000022.11:g.50721582C>T in gene SHANK3 is classified as 'Likely_benign' for Phelan-McDermid_syndrome|Schizophrenia_15. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011652,MedGen:C1853490,OMIM:606232,Orphanet:48652|MONDO:MONDO:0013498,MedGen:C3151380,OMIM:613950. Review status: criteria provided, single submitter.