A: The variant NC_000023.11:g.12888224G>A in gene TLR7 is classified as 'Uncertain_significance' for not_specified|Systemic_lupus_erythematosus. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|Human_Phenotype_Ontology:HP:0002725,MONDO:MONDO:0007915,MedGen:C0024141,OMIM:152700,Orphanet:536. Review status: criteria provided, multiple submitters, no conflicts.