A: The variant NC_000020.11:g.59023753G>A in gene TUBB1 is classified as 'Conflicting_classifications_of_pathogenicity' for Macrothrombocytopenia|TUBB1-related_disorder|Macrothrombocytopenia,_isolated,_1,_autosomal_dominant|Thrombocytopenia|not_provided|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0040185,MedGen:C2751260|.|MONDO:MONDO:0800047,MedGen:C5676892,OMIM:613112,Orphanet:140957|Human_Phenotype_Ontology:HP:0001873,Human_Phenotype_Ontology:HP:0001906,Human_Phenotype_Ontology:HP:0004838,Human_Phenotype_Ontology:HP:0008175,Human_Phenotype_Ontology:HP:0008268,Human_Phenotype_Ontology:HP:0008302,MONDO:MONDO:0002049,MeSH:D013921,MedGen:C0040034|MedGen:C3661900|MedGen:CN169374. Review status: criteria provided, conflicting classifications.