A: The variant NC_000022.11:g.28695227del in gene CHEK2 is classified as 'Pathogenic' for Familial_prostate_cancer|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, multiple submitters, no conflicts.