A: The variant NC_000022.11:g.20982398dup in gene LZTR1 is classified as 'Pathogenic' for Noonan_syndrome_2|RASopathy|not_provided|LZTR1-related_schwannomatosis|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MedGen:C3661900|MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736. Review status: reviewed by expert panel. Oncogenicity: ONC: Likely_oncogenic, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005872048