A: The variant NC_000020.11:g.46128327dup in gene CD40 is classified as 'Benign' for not_specified|not_provided|Hyper-IgM_syndrome_type_3. Molecular consequence: SO:0001627: intron_variant. Variant type: Duplication. Disease database links: MedGen:CN169374|MedGen:C3661900|MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090. Review status: criteria provided, multiple submitters, no conflicts.