A: The variant NC_000019.10:g.18857431C>T in gene UPF1 is classified as 'Uncertain_significance' for Mild_global_developmental_delay|Attention_deficit_hyperactivity_disorder|Delayed_speech_and_language_development|Atypical_behavior|Autistic_behavior|Short_stature. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0011342,MedGen:C4012968|Human_Phenotype_Ontology:HP:0001576,Human_Phenotype_Ontology:HP:0001577,Human_Phenotype_Ontology:HP:0006973,Human_Phenotype_Ontology:HP:0007018,MONDO:MONDO:0007743,MedGen:C1263846|Human_Phenotype_Ontology:HP:0000750,Human_Phenotype_Ontology:HP:0002116,Human_Phenotype_Ontology:HP:0002117,Human_Phenotype_Ontology:HP:0002336,Human_Phenotype_Ontology:HP:0002399,Human_Phenotype_Ontology:HP:0002498,Human_Phenotype_Ontology:HP:0006936,Human_Phenotype_Ontology:HP:0007004,Human_Phenotype_Ontology:HP:0007127,Human_Phenotype_Ontology:HP:0007170,Human_Phenotype_Ontology:HP:0007172,MedGen:C0454644|Human_Phenotype_Ontology:HP:0000708,Human_Phenotype_Ontology:HP:0000715,Human_Phenotype_Ontology:HP:0002368,Human_Phenotype_Ontology:HP:0002456,MedGen:C0004941|Human_Phenotype_Ontology:HP:0000729,MedGen:C0856975|Human_Phenotype_Ontology:HP:0001509,Human_Phenotype_Ontology:HP:0003501,Human_Phenotype_Ontology:HP:0003507,Human_Phenotype_Ontology:HP:0003512,Human_Phenotype_Ontology:HP:0003518,Human_Phenotype_Ontology:HP:0003519,Human_Phenotype_Ontology:HP:0004322,Human_Phenotype_Ontology:HP:0008871,Human_Phenotype_Ontology:HP:0008882,Human_Phenotype_Ontology:HP:0008888,Human_Phenotype_Ontology:HP:0008913,MedGen:C0349588. Review status: criteria provided, single submitter.