A: The variant NC_000019.10:g.38717101C>T in gene ACTN4 is classified as 'Uncertain_significance' for Chronic_kidney_disease|Focal_segmental_glomerulosclerosis_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0000106,Human_Phenotype_Ontology:HP:0001918,Human_Phenotype_Ontology:HP:0008671,Human_Phenotype_Ontology:HP:0012622,MONDO:MONDO:0005300,MedGen:C1561643|MONDO:MONDO:0011303,MedGen:C4551527,OMIM:603278,Orphanet:656. Review status: criteria provided, multiple submitters, no conflicts.