A: The variant NC_000021.9:g.25891783A>C in gene APP is classified as 'Pathogenic' for not_provided|Alzheimer_disease_type_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300. Review status: criteria provided, single submitter.