A: The variant NC_000022.11:g.20994259C>A in gene LZTR1 is classified as 'Pathogenic/Likely_pathogenic' for Cardiovascular_phenotype|Hereditary_cancer-predisposing_syndrome|Noonan_syndrome_2|not_provided. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN230736|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.