A: The variant NC_000022.11:g.30615613dup in gene TCN2 is classified as 'Pathogenic' for Transcobalamin_II_deficiency. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0010149,MedGen:C0342701,OMIM:275350,Orphanet:859. Review status: criteria provided, multiple submitters, no conflicts.