A: The variant NC_000019.10:g.46411993G>A in gene CCDC8 is classified as 'Uncertain_significance' for Immunodeficiency|Inborn_genetic_diseases|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002721,Human_Phenotype_Ontology:HP:0005362,Human_Phenotype_Ontology:HP:0005371,MONDO:MONDO:0021094,MedGen:C0021051,OMIM:PS300755|MeSH:D030342,MedGen:C0950123|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.