A: The variant NC_000019.10:g.15187921G>C in gene NOTCH3 is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310. Review status: criteria provided, conflicting classifications.