A: The variant NC_000019.10:g.15189303A>G in gene NOTCH3 is classified as 'Likely_pathogenic' for Abnormal_cerebral_white_matter_morphology|Migraine_with_aura. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002500,Human_Phenotype_Ontology:HP:0200100,MedGen:C0948163|Human_Phenotype_Ontology:HP:0002077,MONDO:MONDO:0005475,MedGen:C0154723. Review status: no assertion criteria provided.