A: The variant NC_000022.11:g.46357155G>A in gene TRMU is classified as 'Uncertain_significance' for Acute_infantile_liver_failure_due_to_synthesis_defect_of_mtDNA-encoded_proteins. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013111,MedGen:C3278664,OMIM:613070,Orphanet:217371. Review status: criteria provided, single submitter.