A: The variant NC_000021.9:g.37493100G>A in gene DYRK1A is classified as 'Pathogenic' for not_provided|Complex_neurodevelopmental_disorder|Inborn_genetic_diseases. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0100038,MedGen:C5568766,Orphanet:528084|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.