A: The variant NC_000020.11:g.45971125C>T in gene ZNF335 is classified as 'Uncertain_significance' for Autosomal_recessive_primary_microcephaly. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016660,MedGen:C3711387,OMIM:PS251200,Orphanet:2512. Review status: criteria provided, single submitter.