A: The variant NC_000019.10:g.45553615_45553616del in gene OPA3 is classified as 'Uncertain_significance' for 3-Methylglutaconic_aciduria|Optic_atrophy_3|3-Methylglutaconic_aciduria_type_3. Molecular consequence: SO:0001589: frameshift_variant,SO:0001627: intron_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0003535,MONDO:MONDO:0017359,MedGen:C3696376,OMIM:PS250950,Orphanet:289902|MONDO:MONDO:0008133,MedGen:C1833809,OMIM:165300,Orphanet:67036|MONDO:MONDO:0009787,MedGen:C0574084,OMIM:258501,Orphanet:67047. Review status: criteria provided, single submitter.