A: The variant NC_000022.11:g.50626265G>A in gene ARSA is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Metachromatic_leukodystrophy|Spastic_ataxia. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0018868,MedGen:C0023522,OMIM:250100,Orphanet:512|Human_Phenotype_Ontology:HP:0002497,MONDO:MONDO:0017845,MedGen:C1849156,OMIM:PS108600,Orphanet:316226. Review status: criteria provided, multiple submitters, no conflicts.