A: The variant NC_000020.11:g.49547935C>T in gene PTGIS is classified as 'Uncertain_significance' for Essential_hypertension. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0001134,MedGen:C0085580. Review status: criteria provided, single submitter.