A: The variant NC_000019.10:g.15189033G>A in gene NOTCH3 is classified as 'Uncertain_significance' for Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136. Review status: criteria provided, single submitter.