A: The variant NC_000022.11:g.37069344_37069345insGTGGG in gene TMPRSS6 is classified as 'Uncertain_significance' for Iron-refractory_iron_deficiency_anemia. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Insertion. Disease database links: MONDO:MONDO:0008788,MedGen:C0085576,OMIM:206200,Orphanet:209981. Review status: criteria provided, single submitter.