A: The variant NC_000023.11:g.15321637_15321638insTTTCAATGATAGAATCTGGAGTCATCCATCTCAA in gene PIGA is classified as 'Pathogenic' for Paroxysmal_nocturnal_hemoglobinuria. Molecular consequence: SO:0001587: nonsense,SO:0001619: non-coding_transcript_variant. Variant type: Insertion. Disease database links: Human_Phenotype_Ontology:HP:0004818,MONDO:MONDO:0100244,MedGen:C0024790,OMIM:PS300818,Orphanet:447. Review status: no assertion criteria provided.