A: The variant NC_000022.11:g.42619773T>C in gene CYB5R3 is classified as 'Uncertain_significance' for Hereditary_methemoglobinemia. Molecular consequence: SO:0001578: stop_lost. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018963,MedGen:C0272087,Orphanet:621. Review status: no assertion criteria provided.