A: The variant NC_000020.11:g.46126737G>C in gene CD40 is classified as 'Benign' for Hyper-IgM_syndrome_type_3|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011735,MedGen:C1720957,OMIM:606843,Orphanet:101090|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.