A: The variant NC_000022.11:g.41178509_41178511del in gene EP300 is classified as 'Benign/Likely_benign' for not_specified|Rubinstein-Taybi_syndrome_due_to_CREBBP_mutations|not_provided|EP300-related_disorder|Rubinstein-Taybi_syndrome_due_to_EP300_haploinsufficiency. Molecular consequence: SO:0001822: inframe_deletion. Variant type: Deletion. Disease database links: MedGen:CN169374|MONDO:MONDO:0008393,MedGen:C4551859,OMIM:180849,Orphanet:353277,Orphanet:783|MedGen:C3661900|.|MONDO:MONDO:0013364,MedGen:C3150941,OMIM:613684,Orphanet:353284,Orphanet:783. Review status: criteria provided, multiple submitters, no conflicts.