A: The variant NC_000021.9:g.36461442A>T in gene CLDN14 is classified as 'Pathogenic' for Autosomal_recessive_nonsyndromic_hearing_loss_29|Hearing_loss,_autosomal_recessive|Hearing_impairment. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013537,MedGen:C3279660,OMIM:614035,Orphanet:90636|MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636|Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666. Review status: criteria provided, single submitter.