A: The variant NC_000019.10:g.18169181C>T in gene PIK3R2 is classified as 'Likely_benign' for Megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome_1. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011313,MedGen:C4012727,OMIM:603387,Orphanet:83473. Review status: criteria provided, single submitter.