A: The variant NC_000019.10:g.18786139C>T in gene COMP is classified as 'Likely_pathogenic' for Multiple_epiphyseal_dysplasia_type_1. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007561,MedGen:C1838280,OMIM:132400,Orphanet:93308. Review status: criteria provided, single submitter.