A: The variant NC_000020.11:g.5952149G>A in gene MCM8 is classified as 'Uncertain_significance' for Premature_ovarian_failure_10. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0044776,MedGen:C4225402,OMIM:612885. Review status: criteria provided, single submitter.