A: The variant NC_000021.9:g.42395381dup in gene TMPRSS3 is classified as 'Pathogenic' for Autosomal_recessive_nonsyndromic_hearing_loss_8. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636. Review status: criteria provided, single submitter.