A: The variant NC_000019.10:g.49662594C>G in gene IRF3 is classified as 'Benign/Likely_benign' for Encephalopathy,_acute,_infection-induced_(herpes-specific),_susceptibility_to,_7|not_provided|IRF3-related_disorder. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001623: 5_prime_UTR_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0014680,MedGen:C4225294,OMIM:616532,Orphanet:1930|MedGen:C3661900|.. Review status: criteria provided, multiple submitters, no conflicts.