A: The variant NC_000020.11:g.4699570C>T in gene PRNP is classified as 'Pathogenic' for not_provided|Gerstmann-Straussler-Scheinker_syndrome|Inborn_genetic_diseases. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0007656,MedGen:C0017495,OMIM:137440,Orphanet:356|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.