A: The variant NC_000019.10:g.15185505C>T in gene NOTCH3 is classified as 'Likely_pathogenic' for Progressive_psychomotor_deterioration. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0006856,Human_Phenotype_Ontology:HP:0007272,MedGen:C1856565. Review status: no assertion criteria provided.