A: The variant NC_000021.9:g.42486463T>G in gene RSPH1 is classified as 'Pathogenic' for not_provided|Kartagener_syndrome|Primary_ciliary_dyskinesia_24|Primary_ciliary_dyskinesia|RSPH1-related_disorder. Molecular consequence: SO:0001574: splice_acceptor_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0009484,MedGen:C4551906,OMIM:244400,Orphanet:244,Orphanet:98861|MONDO:MONDO:0014202,MedGen:C3809634,OMIM:615481,Orphanet:244|Human_Phenotype_Ontology:HP:0012265,MONDO:MONDO:0016575,MedGen:C0008780,OMIM:PS244400,Orphanet:244|.. Review status: criteria provided, multiple submitters, no conflicts.