A: The variant NC_000022.11:g.42628144C>G in gene CYB5R3 is classified as 'Pathogenic' for METHEMOGLOBINEMIA,_TYPE_II. Molecular consequence: SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C2749560. Review status: no assertion criteria provided.