A: The variant NC_000019.10:g.42250340C>T in gene ERF is classified as 'Conflicting_classifications_of_pathogenicity' for Inborn_genetic_diseases|TWIST1-related_craniosynostosis|Craniosynostosis_4|See_cases. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MeSH:D030342,MedGen:C0950123|MONDO:MONDO:0007399,MedGen:C4551902,OMIM:123100,Orphanet:63440|Human_Phenotype_Ontology:HP:0004443,Human_Phenotype_Ontology:HP:0004486,MONDO:MONDO:0010929,MedGen:C1833340,OMIM:600775|.. Review status: criteria provided, conflicting classifications.