A: The variant NC_000022.11:g.28689152dup in gene CHEK2 is classified as 'Likely_pathogenic' for Familial_cancer_of_breast. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Duplication. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, single submitter.