A: The variant NC_000021.9:g.36754285G>A in gene HLCS is classified as 'Benign/Likely_benign' for not_provided|not_specified|Holocarboxylase_synthetase_deficiency. Molecular consequence: SO:0001619: non-coding_transcript_variant,SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MedGen:CN169374|MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242. Review status: criteria provided, multiple submitters, no conflicts.