A: The variant NC_000022.11:g.42627326C>T in gene CYB5R3 is classified as 'Pathogenic' for METHEMOGLOBINEMIA,_TYPE_I|Hereditary_methemoglobinemia. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C2749559|MONDO:MONDO:0018963,MedGen:C0272087,Orphanet:621. Review status: no assertion criteria provided.