A: The variant NC_000019.10:g.38580090C>T in gene RYR1 is classified as 'Conflicting_classifications_of_pathogenicity' for Central_core_myopathy|Malignant_hyperthermia,_susceptibility_to,_1|RYR1-related_disorder|Lynch_syndrome_5|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MedGen:CN239331|MONDO:MONDO:0013710,MedGen:C1833477,OMIM:614350,Orphanet:144|MedGen:C3661900. Review status: criteria provided, conflicting classifications.