A: The variant NC_000021.9:g.36765159dup in gene HLCS is classified as 'Pathogenic/Likely_pathogenic' for not_provided|Holocarboxylase_synthetase_deficiency|Inborn_genetic_diseases. Molecular consequence: SO:0001589: frameshift_variant,SO:0001619: non-coding_transcript_variant. Variant type: Duplication. Disease database links: MedGen:C3661900|MONDO:MONDO:0009666,MedGen:C0268581,OMIM:253270,Orphanet:79242|MeSH:D030342,MedGen:C0950123. Review status: criteria provided, multiple submitters, no conflicts.