A: The variant NC_000019.10:g.29702977C>T in gene C19orf12 is classified as 'Pathogenic/Likely_pathogenic' for Neurodegeneration_with_brain_iron_accumulation|not_provided|Neurodegeneration_with_brain_iron_accumulation_4|Hereditary_spastic_paraplegia_43. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0018307,MedGen:C2931845,OMIM:PS234200,Orphanet:385|MedGen:C3661900|MONDO:MONDO:0013674,MedGen:C3280371,OMIM:614298,Orphanet:289560|MONDO:MONDO:0014024,MedGen:C2680446,OMIM:615043,Orphanet:320370. Review status: criteria provided, multiple submitters, no conflicts.