A: The variant NC_000021.9:g.44235470G>A in gene ICOSLG is classified as 'Likely_pathogenic' for Combined_immunodeficiency. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0005387,MONDO:MONDO:0015131,MedGen:C2711630,Orphanet:101972. Review status: criteria provided, single submitter.