A: The variant NC_000021.9:g.45456080G>A in gene COL18A1 is classified as 'Uncertain_significance' for not_provided|Hereditary_glaucoma,_primary_closed-angle. Molecular consequence: SO:0001583: missense_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0030038,MedGen:C5394374,OMIM:618880. Review status: criteria provided, single submitter.