A: The variant NC_000021.9:g.43630339A>G in gene HSF2BP is classified as 'Likely_pathogenic' for Premature_ovarian_failure_19. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030985,MedGen:C5543229,OMIM:619245. Review status: criteria provided, single submitter.