A: The variant NC_000021.9:g.42388935G>A in gene TMPRSS3 is classified as 'Pathogenic/Likely_pathogenic' for not_provided|TMPRSS3-related_disorder|Autosomal_recessive_nonsyndromic_hearing_loss_8|Hearing_impairment. Molecular consequence: SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|.|MONDO:MONDO:0010987,MedGen:C1832827,OMIM:601072,Orphanet:90636|Human_Phenotype_Ontology:HP:0000365,Human_Phenotype_Ontology:HP:0000404,Human_Phenotype_Ontology:HP:0001728,Human_Phenotype_Ontology:HP:0001729,Human_Phenotype_Ontology:HP:0001754,Human_Phenotype_Ontology:HP:0008560,Human_Phenotype_Ontology:HP:0008563,MONDO:MONDO:0005365,MedGen:C1384666. Review status: criteria provided, multiple submitters, no conflicts.