A: The variant NC_000022.11:g.28710002_28710005del in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Carcinoma_of_pancreas|Hereditary_breast_ovarian_cancer_syndrome|Breast-ovarian_cancer,_familial,_susceptibility_to,_1|CHEK2-related_cancer_predisposition|Familial_cancer_of_breast|Hereditary_nonpolyposis_colon_cancer|not_provided|Endometrial_carcinoma|Hereditary_cancer-predisposing_syndrome|not_specified|Familial_prostate_cancer|Bone_osteosarcoma. Molecular consequence: SO:0001575: splice_donor_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0005192,MeSH:C562463,MedGen:C0235974,Orphanet:1333,Orphanet:217074|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0011450,MedGen:C2676676,OMIM:604370,Orphanet:145|MONDO:MONDO:0700271,MedGen:C5882668,OMIM:609265,Orphanet:524|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0018630,MedGen:C1333990,OMIM:PS120435,Orphanet:443909|MedGen:C3661900|Human_Phenotype_Ontology:HP:0012114,MONDO:MONDO:0002447,MedGen:C0476089,OMIM:608089|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN169374|MONDO:MONDO:0700275,MedGen:C2931456,OMIM:176807,Orphanet:1331|MONDO:MONDO:0002629,MedGen:C0585442,OMIM:259500,Orphanet:668. Review status: criteria provided, multiple submitters, no conflicts.