A: The variant NC_000022.11:g.28703519A>C in gene CHEK2 is classified as 'Pathogenic/Likely_pathogenic' for Familial_cancer_of_breast|Hereditary_breast_ovarian_cancer_syndrome|Breast-ovarian_cancer,_familial,_susceptibility_to,_1|Uterine_corpus_cancer|Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0003582,MeSH:D061325,MedGen:C0677776,Orphanet:145|MONDO:MONDO:0011450,MedGen:C2676676,OMIM:604370,Orphanet:145|MONDO:MONDO:0006003,MedGen:C1883486|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, multiple submitters, no conflicts.