A: The variant NC_000021.9:g.43065453C>T in gene CBS is classified as 'Conflicting_classifications_of_pathogenicity' for Familial_thoracic_aortic_aneurysm_and_aortic_dissection|HYPERHOMOCYSTEINEMIA,_THROMBOTIC,_CBS-RELATED|Classic_homocystinuria|CBS-related_disorder. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0019625,MedGen:C4707243,OMIM:PS607086,Orphanet:91387|MedGen:C3150344|MONDO:MONDO:0009352,MedGen:C0751202,OMIM:236200,Orphanet:394|.. Review status: criteria provided, conflicting classifications.