A: The variant NC_000019.10:g.46411848del in gene CCDC8 is classified as 'Likely_pathogenic' for 3M_syndrome_3. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0013627,MedGen:C3280146,OMIM:614205,Orphanet:2616. Review status: criteria provided, single submitter.