A: The variant NC_000019.10:g.38517547C>T in gene RYR1 is classified as 'Uncertain_significance' for Malignant_hyperthermia,_susceptibility_to,_1|RYR1-related_myopathy|RYR1-related_disorder|Congenital_myopathy_with_fiber_type_disproportion. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|MONDO:MONDO:0100150,MedGen:CN305348|MedGen:CN239331|MONDO:MONDO:0009711,MedGen:C0546264,Orphanet:2020. Review status: reviewed by expert panel.