A: The variant NC_000019.10:g.38455471C>T in gene RYR1 is classified as 'Pathogenic|drug_response' for RYR1-related_disorder|Central_core_myopathy|King_Denborough_syndrome|Malignant_hyperthermia,_susceptibility_to,_1|Congenital_multicore_myopathy_with_external_ophthalmoplegia|desflurane_response_-_Toxicity|succinylcholine_response_-_Toxicity|sevoflurane_response_-_Toxicity|Malignant_hyperthermia_of_anesthesia|methoxyflurane_response_-_Toxicity|isoflurane_response_-_Toxicity|halothane_response_-_Toxicity|enflurane_response_-_Toxicity|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN239331|MONDO:MONDO:0007294,MedGen:C5830701,OMIM:117000,Orphanet:597|MONDO:MONDO:0020485,MedGen:C1840365,OMIM:619542|MONDO:MONDO:0007783,MedGen:C2930980,OMIM:145600,Orphanet:423|Human_Phenotype_Ontology:HP:0003789,Human_Phenotype_Ontology:HP:0003804,MONDO:MONDO:0009712,MedGen:C1850674,OMIM:255320,Orphanet:598,Orphanet:98905|.|.|.|Human_Phenotype_Ontology:HP:0034733,MONDO:MONDO:0018493,MedGen:C0024591,Orphanet:423|.|.|.|.|MedGen:C3661900. Review status: reviewed by expert panel.