A: The variant NC_000022.11:g.28703520_28703524del in gene CHEK2 is classified as 'Pathogenic' for Hereditary_nonpolyposis_colon_cancer|not_provided|Familial_cancer_of_breast|Hereditary_cancer-predisposing_syndrome. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0018630,MedGen:C1333990,OMIM:PS120435,Orphanet:443909|MedGen:C3661900|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162. Review status: criteria provided, multiple submitters, no conflicts.