A: The variant NC_000019.10:g.15191611G>A in gene NOTCH3 is classified as 'Likely_benign' for Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310. Review status: no assertion criteria provided.