A: The variant NC_000021.9:g.42879495T>C in gene WDR4 is classified as 'Likely_pathogenic' for Microcephaly,_growth_deficiency,_seizures,_and_brain_malformations. Molecular consequence: SO:0001582: initiator_codon_variant,SO:0001583: missense_variant,SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032690,MedGen:C5193042,OMIM:618346. Review status: criteria provided, single submitter.