A: The variant NC_000020.11:g.4699752G>A in gene PRNP is classified as 'Pathogenic/Likely_pathogenic' for Huntington_disease-like_1|Fatal_familial_insomnia|Gerstmann-Straussler-Scheinker_syndrome|Spongiform_encephalopathy_with_neuropsychiatric_features|not_provided. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011299,MedGen:C1864112,OMIM:603218,Orphanet:157941|MONDO:MONDO:0010808,MedGen:C0206042,OMIM:600072,Orphanet:466|MONDO:MONDO:0007656,MedGen:C0017495,OMIM:137440,Orphanet:356|MONDO:MONDO:0011703,MedGen:C1847650,OMIM:606688|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.