A: The variant NC_000020.11:g.49249555G>C in gene ZNFX1 is classified as 'Uncertain_significance' for Immunodeficiency_91_and_hyperinflammation. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0030491,MedGen:C5562073,OMIM:619644. Review status: criteria provided, single submitter.