A: The variant NC_000022.11:g.19962521C>T in gene COMT is classified as 'drug_response' for Tramadol_response. Molecular consequence: SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN078023. Review status: no assertion criteria provided.