A: The variant NC_000020.11:g.49524188G>A in gene PTGIS is classified as 'Uncertain_significance' for Essential_hypertension,_genetic|not_specified. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007781,MedGen:CN305331,OMIM:145500|MedGen:CN169374. Review status: criteria provided, multiple submitters, no conflicts.