A: The variant NC_000019.10:g.15187220C>G in gene NOTCH3 is classified as 'Benign/Likely_benign' for Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|not_specified|not_provided. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|MedGen:CN169374|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.