A: The variant NC_000021.9:g.45222084G>T in gene ADARB1 is classified as 'Benign' for Abnormal_CNS_myelination|Microcephaly|Encephalopathy. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0002520,Human_Phenotype_Ontology:HP:0004335,Human_Phenotype_Ontology:HP:0011400,MedGen:C4021152|Human_Phenotype_Ontology:HP:0000252,Human_Phenotype_Ontology:HP:0001366,Human_Phenotype_Ontology:HP:0005485,Human_Phenotype_Ontology:HP:0005489,Human_Phenotype_Ontology:HP:0005497,MONDO:MONDO:0001149,MedGen:C4551563|Human_Phenotype_Ontology:HP:0001298,MedGen:C0085584. Review status: criteria provided, single submitter.