A: The variant NC_000021.9:g.33432794T>C in gene TMEM50B is classified as 'Uncertain_significance' for Immunodeficiency_28. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0013953,MedGen:C4013947,OMIM:614889,Orphanet:319547,Orphanet:319574. Review status: criteria provided, single submitter.