A: The variant NC_000020.11:g.58909365C>T in gene GNAS is classified as 'Pathogenic/Likely_pathogenic' for Pseudohypoparathyroidism_type_1B|Pituitary_adenoma_3,_multiple_types|not_provided|Sex_cord-stromal_tumor|McCune-Albright_syndrome|ACTH-independent_macronodular_adrenal_hyperplasia_1. Molecular consequence: SO:0001583: missense_variant,SO:0001624: 3_prime_UTR_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0011301,MedGen:C1864100,OMIM:603233,Orphanet:94089|MONDO:MONDO:0054665,MedGen:C4540135,OMIM:617686|MedGen:C3661900|MONDO:MONDO:0006055,MedGen:C0206724|MONDO:MONDO:0018919,MedGen:C0242292,OMIM:174800,Orphanet:562|MONDO:MONDO:0020735,MedGen:C1857451,OMIM:219080. Review status: criteria provided, multiple submitters, no conflicts. Oncogenicity: ONC: Oncogenic, ONCDISDB: Human_Phenotype_Ontology:HP:0002664,Human_Phenotype_Ontology:HP:0003008,Human_Phenotype_Ontology:HP:0006741,MONDO:MONDO:0005070,MeSH:D009369,MedGen:C0027651, ONCDN: Neoplasm, ONCREVSTAT: criteria_provided,_single_submitter, ONCSCV: SCV005094025