A: The variant NC_000019.10:g.29708415G>A in gene C19orf12 is classified as 'Pathogenic/Likely_pathogenic' for Abnormality_of_iron_homeostasis|Hereditary_spastic_paraplegia_43|Neurodegeneration_with_brain_iron_accumulation_4|not_provided|Neurodegeneration_with_brain_iron_accumulation. Molecular consequence: SO:0001623: 5_prime_UTR_variant,SO:0001627: intron_variant. Variant type: single_nucleotide_variant. Disease database links: Human_Phenotype_Ontology:HP:0011031,MedGen:C4023583|MONDO:MONDO:0014024,MedGen:C2680446,OMIM:615043,Orphanet:320370|MONDO:MONDO:0013674,MedGen:C3280371,OMIM:614298,Orphanet:289560|MedGen:C3661900|MONDO:MONDO:0018307,MedGen:C2931845,OMIM:PS234200,Orphanet:385. Review status: criteria provided, multiple submitters, no conflicts.