A: The variant NC_000019.10:g.41892659G>A in gene ARHGEF1 is classified as 'Uncertain_significance' for Immunodeficiency_62. Molecular consequence: SO:0001583: missense_variant,SO:0001619: non-coding_transcript_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0032763,MedGen:C5193109,OMIM:618459. Review status: criteria provided, single submitter.