A: The variant NC_000022.11:g.20992878C>T in gene LZTR1 is classified as 'Uncertain_significance' for not_specified|Cardiovascular_phenotype|Hereditary_cancer-predisposing_syndrome|Noonan_syndrome_and_Noonan-related_syndrome|Noonan_syndrome_10|RASopathy|Non-immune_hydrops_fetalis|not_provided|LZTR1-related_disorder|LZTR1-related_schwannomatosis. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:CN169374|MedGen:CN230736|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MONDO:MONDO:0020297,MedGen:C5681679,Orphanet:98733|MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648|MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|Human_Phenotype_Ontology:HP:0001790,MONDO:MONDO:0009369,MedGen:C0455988,OMIM:236750,Orphanet:363999|MedGen:C3661900|.|MONDO:MONDO:0014299,MedGen:C3810283,OMIM:615670,Orphanet:93921. Review status: reviewed by expert panel.