A: The variant NC_000019.10:g.45584738C>T in gene OPA3 is classified as 'Likely_benign' for Optic_atrophy_3|3-Methylglutaconic_aciduria_type_3. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0008133,MedGen:C1833809,OMIM:165300,Orphanet:67036|MONDO:MONDO:0009787,MedGen:C0574084,OMIM:258501,Orphanet:67047. Review status: criteria provided, single submitter.