A: The variant NC_000022.11:g.45399345T>C in gene SMC1B is classified as 'Likely_pathogenic' for Genetic_non-acquired_premature_ovarian_failure. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C5925042,Orphanet:485382. Review status: no assertion criteria provided.