A: The variant NC_000019.10:g.49861484A>G in gene PNKP is classified as 'Conflicting_classifications_of_pathogenicity' for not_provided|Microcephaly,_seizures,_and_developmental_delay|PNKP-related_disorder|Developmental_and_epileptic_encephalopathy,_12. Molecular consequence: SO:0001819: synonymous_variant. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0013254,MedGen:C3150667,OMIM:613402,Orphanet:1934|.|MONDO:MONDO:0013389,MedGen:C3150988,OMIM:613722. Review status: criteria provided, conflicting classifications.