A: The variant NC_000019.10:g.15187255C>T in gene NOTCH3 is classified as 'Conflicting_classifications_of_pathogenicity' for Cerebral_autosomal_dominant_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy|Cerebral_arteriopathy,_autosomal_dominant,_with_subcortical_infarcts_and_leukoencephalopathy,_type_1|not_provided|NOTCH3-related_disorder. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0007432,MedGen:C0751587,OMIM:PS125310|MONDO:MONDO:0000914,MedGen:C4551768,OMIM:125310,Orphanet:136|MedGen:C3661900|.. Review status: criteria provided, conflicting classifications.