A: The variant NC_000022.11:g.28703527C>G in gene CHEK2 is classified as 'Uncertain_significance' for Familial_cancer_of_breast|Hereditary_cancer-predisposing_syndrome|not_provided. Molecular consequence: SO:0001583: missense_variant. Variant type: single_nucleotide_variant. Disease database links: MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:C3661900. Review status: criteria provided, multiple submitters, no conflicts.