A: The variant NC_000019.10:g.19527301del in gene NDUFA13 is classified as 'Pathogenic' for Hypertrophic_cardiomyopathy|Severe_global_developmental_delay|Decreased_activity_of_mitochondrial_complex_I|Nystagmus|Lactic_acidosis|Leigh_syndrome|Mitochondrial_complex_1_deficiency,_nuclear_type_28. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: Human_Phenotype_Ontology:HP:0001639,MONDO:MONDO:0005045,MeSH:D002312,MedGen:C0007194,Orphanet:217569|Human_Phenotype_Ontology:HP:0011344,MedGen:C1837397|Human_Phenotype_Ontology:HP:0011923,MedGen:C2677650|Human_Phenotype_Ontology:HP:0000639,MONDO:MONDO:0004843,MedGen:C0028738|Human_Phenotype_Ontology:HP:0003128,Human_Phenotype_Ontology:HP:0003255,Human_Phenotype_Ontology:HP:0005960,MONDO:MONDO:0006040,MedGen:C0001125|MONDO:MONDO:0009723,MedGen:C2931891,OMIM:256000,Orphanet:506|MONDO:MONDO:0032632,MedGen:C4748827,OMIM:618249. Review status: criteria provided, single submitter.