A: The variant NC_000022.11:g.20997326_20997327del in gene LZTR1 is classified as 'Pathogenic' for Noonan_syndrome_10. Molecular consequence: SO:0001589: frameshift_variant. Variant type: Deletion. Disease database links: MONDO:MONDO:0014693,MedGen:C4225280,OMIM:616564,Orphanet:648. Review status: criteria provided, single submitter.