A: The variant NC_000022.11:g.20996071C>A in gene LZTR1 is classified as 'Pathogenic' for not_provided|Hereditary_cancer-predisposing_syndrome|Cardiovascular_phenotype|RASopathy|Noonan_syndrome_2. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|MedGen:CN230736|MONDO:MONDO:0021060,MedGen:C5555857,Orphanet:536391|MONDO:MONDO:0011531,MedGen:C1854469,OMIM:605275,Orphanet:648. Review status: reviewed by expert panel.