A: The variant NC_000022.11:g.28711986C>A in gene CHEK2 is classified as 'Pathogenic' for not_provided|Hereditary_cancer-predisposing_syndrome|Prostate_cancer|Colorectal_cancer|Familial_cancer_of_breast. Molecular consequence: SO:0001587: nonsense. Variant type: single_nucleotide_variant. Disease database links: MedGen:C3661900|MONDO:MONDO:0015356,MeSH:D009386,MedGen:C0027672,Orphanet:140162|Human_Phenotype_Ontology:HP:0012125,MONDO:MONDO:0008315,MedGen:C0376358,Orphanet:1331|MONDO:MONDO:0005575,MedGen:C0346629,OMIM:114500|MONDO:MONDO:0016419,MedGen:C0346153,OMIM:114480,Orphanet:227535. Review status: criteria provided, multiple submitters, no conflicts.